                         SEQUENCE LISTING

<110>  University of Florida Research Foundation, Inc.
 
<120>  AAV-BASED GENE THERAPY FOR MULTIPLE SCLEROSIS

<130>  U1197.70049WO00

<150>  US 61/983,924
<151>  2014-04-24

<160>  37    

<170>  PatentIn version 3.5

<210>  1
<211>  195
<212>  PRT
<213>  Mus musculus

<400>  1

Met Gly Asn His Ser Gly Lys Arg Glu Leu Ser Ala Glu Lys Ala Ser 
1               5                   10                  15      


Lys Asp Gly Glu Ile His Arg Gly Glu Ala Gly Lys Lys Arg Ser Val 
            20                  25                  30          


Gly Lys Leu Ser Gln Thr Ala Ser Glu Asp Ser Asp Val Phe Gly Glu 
        35                  40                  45              


Ala Asp Ala Ile Gln Asn Asn Gly Thr Ser Ala Glu Asp Thr Ala Val 
    50                  55                  60                  


Thr Asp Ser Lys His Thr Ala Asp Pro Lys Asn Asn Trp Gln Gly Ala 
65                  70                  75                  80  


His Pro Ala Asp Pro Gly Asn Arg Pro His Leu Ile Arg Leu Phe Ser 
                85                  90                  95      


Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 
            100                 105                 110         


Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Pro Thr Ala Ala Ser 
        115                 120                 125             


Gly Gly Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg Ser 
    130                 135                 140                 


Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe 
145                 150                 155                 160 


Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe 
                165                 170                 175     


Phe Ser Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Ser 
            180                 185                 190         


Ser Glu Pro 
        195 


<210>  2
<211>  248
<212>  PRT
<213>  Mus musculus

<400>  2

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 
        115                 120                 125             


Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 
    130                 135                 140                 


Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 
145                 150                 155                 160 


Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 
                165                 170                 175     


Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
            180                 185                 190         


Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 
        195                 200                 205             


Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 
    210                 215                 220                 


Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 
225                 230                 235                 240 


Ile Ala Ala Phe Val Gly Ala Ala 
                245             


<210>  3
<211>  247
<212>  PRT
<213>  Mus musculus

<400>  3

Met Ala Cys Leu Trp Ser Phe Ser Leu Pro Ser Cys Phe Leu Ser Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Leu Ser Cys Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Gly Tyr Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Ala Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Ala Glu Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Glu Thr Ile Ser Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Gln Asn Val Arg Phe Ser Asp Glu Gly Gly Tyr Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Asn Pro Gly Val Leu Thr Leu Ile Ala 
145                 150                 155                 160 


Leu Val Pro Thr Ile Leu Leu Gln Val Ser Val Gly Leu Val Phe Leu 
                165                 170                 175     


Phe Leu Gln His Arg Leu Arg Gly Lys Leu Arg Ala Glu Val Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Arg Asn Pro Leu 
                245         


<210>  4
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PLP peptide

<400>  4

His Cys Leu Gly Lys Trp Leu Gly His Pro Asp Lys Phe 
1               5                   10              


<210>  5
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PLP pepitde

<400>  5

Asn Thr Trp Thr Cys Gln Ser Ile Ala Phe Pro 
1               5                   10      


<210>  6
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MOG peptide

<400>  6

Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys 
            20      


<210>  7
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  MOG peptide

<400>  7

Asp Glu Gly Gly Tyr Thr Cys Phe Phe Arg Asp His Ser Tyr Gln 
1               5                   10                  15  


<210>  8
<211>  744
<212>  DNA
<213>  Mus musculus

<400>  8
atggcctgtt tgtggagctt ctctttgccc agctgcttcc tctcccttct cctcctcctt       60

ctcctccagt tgtcatgcag ctatgcagga caattcagag tgataggacc agggtatccc      120

atccgggctt tagttgggga tgaagcagag ctgccgtgcc gcatctctcc tgggaaaaat      180

gccacgggca tggaggtggg ttggtaccgt tctcccttct caagagtggt tcacctctac      240

cgaaatggca aggaccaaga tgcagagcaa gcacctgaat accggggacg cacagagctt      300

ctgaaagaga ctatcagtga gggaaaggtt acccttagga ttcagaacgt gagattctca      360

gatgaaggag gctacacctg cttcttcaga gaccactctt accaagaaga ggcagcaatg      420

gagttgaaag tggaagatcc cttctattgg gtcaaccccg gtgtgctgac tctcatcgca      480

cttgtgccta cgatcctcct gcaggtctct gtaggccttg tattcctctt cctgcagcac      540

agactgagag gaaaacttcg tgcagaagta gagaatctcc atcggacttt tgatcctcac      600

ttcctgaggg tgccctgctg gaagataaca ctgtttgtta ttgtgcctgt tcttggaccc      660

ctggttgcct tgatcatctg ctacaactgg ctgcaccgaa gactggcagg acagtttctt      720

gaagagctaa gaaaccccct ttga                                             744


<210>  9
<211>  247
<212>  PRT
<213>  Mus musculus

<400>  9

Met Ala Cys Leu Trp Ser Phe Ser Trp Pro Ser Cys Phe Leu Ser Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Leu Ser Cys Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Gly Tyr Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Ala Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Ala Glu Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Glu Thr Ile Ser Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Gln Asn Val Arg Phe Ser Asp Glu Gly Gly Tyr Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Asn Pro Gly Val Leu Thr Leu Ile Ala 
145                 150                 155                 160 


Leu Val Pro Thr Ile Leu Leu Gln Val Ser Val Gly Leu Val Phe Leu 
                165                 170                 175     


Phe Leu Gln His Arg Leu Arg Gly Lys Leu Arg Ala Glu Val Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Arg Asn Pro Phe 
                245         


<210>  10
<211>  834
<212>  DNA
<213>  Mus musculus

<400>  10
atgggcttgt tagagtgttg tgctagatgt ctggtagggg ccccctttgc ttccctggtg       60

gccactggat tgtgtttctt tggagtggca ctgttctgtg gatgtggaca tgaagctctc      120

actggtacag aaaagctaat tgagacctat ttctccaaaa actaccagga ctatgagtat      180

ctcattaatg tgattcatgc tttccagtat gtcatctatg gaactgcctc tttcttcttc      240

ctttatgggg ccctcctgct ggctgagggc ttctacacca ccggcgctgt caggcagatc      300

tttggcgact acaagaccac catctgcggc aagggcctga gcgcaacggt aacagggggc      360

cagaagggga ggggttccag aggccaacat caagctcatt ctttggagcg ggtgtgtcat      420

tgtttgggaa aatggctagg acatcccgac aagtttgtgg gcatcaccta tgccctgact      480

gttgtatggc tcctggtgtt tgcctgctcg gctgtacctg tgtacattta cttcaatacc      540

tggaccacct gtcagtctat tgccttccct agcaagacct ctgccagtat aggcagtctc      600

tgcgctgatg ccagaatgta tggtgttctc ccatggaatg ctttccctgg caaggtttgt      660

ggctccaacc ttctgtccat ctgcaaaaca gctgagttcc aaatgacctt ccacctgttt      720

attgctgcgt ttgtgggtgc tgcggccaca ctagtttccc tgctcacctt catgattgct      780

gccacttaca acttcgccgt ccttaaactc atgggccgag gcaccaagtt ctga            834


<210>  11
<211>  277
<212>  PRT
<213>  Mus musculus

<400>  11

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 
        115                 120                 125             


Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 
    130                 135                 140                 


Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 
145                 150                 155                 160 


Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 
                165                 170                 175     


Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
            180                 185                 190         


Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 
        195                 200                 205             


Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 
    210                 215                 220                 


Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 
225                 230                 235                 240 


Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 
                245                 250                 255     


Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 
            260                 265                 270         


Arg Gly Thr Lys Phe 
        275         


<210>  12
<211>  588
<212>  DNA
<213>  Mus musculus

<400>  12
atgggaaacc actctggaaa gagagaatta tctgctgaga aggccagtaa ggatggagag       60

attcaccgag gagaggctgg aaagaagaga agcgtgggca agctttctca gacggcctca      120

gaggacagtg atgtgtttgg ggaggcagat gcgatccaga acaatgggac ctcggctgag      180

gacacggcgg tgacagactc caagcacaca gcagacccaa agaataactg gcaaggcgcc      240

cacccagctg acccagggaa ccgcccccac ttgatccgcc tcttttcccg agatgccccg      300

ggaagggagg acaacacctt caaagacagg ccctcagagt ccgacgagct tcagaccatc      360

caagaagacc ccacagcagc ttccggaggc ctggatgtga tggcatcaca gaagagaccc      420

tcacagcgat ccaagtacct ggccacagca agtaccatgg accatgccag gcatggcttc      480

ctcccaaggc acagagacac gggcatcctt gactccatcg ggcgcttctt tagcggtgac      540

aggggtgcgc ccaagcgggg ctctggcaag gtgagctccg agccgtag                   588


<210>  13
<211>  195
<212>  PRT
<213>  Mus musculus

<400>  13

Met Gly Asn His Ser Gly Lys Arg Glu Leu Ser Ala Glu Lys Ala Ser 
1               5                   10                  15      


Lys Asp Gly Glu Ile His Arg Gly Glu Ala Gly Lys Lys Arg Ser Val 
            20                  25                  30          


Gly Lys Leu Ser Gln Thr Ala Ser Glu Asp Ser Asp Val Phe Gly Glu 
        35                  40                  45              


Ala Asp Ala Ile Gln Asn Asn Gly Thr Ser Ala Glu Asp Thr Ala Val 
    50                  55                  60                  


Thr Asp Ser Lys His Thr Ala Asp Pro Lys Asn Asn Trp Gln Gly Ala 
65                  70                  75                  80  


His Pro Ala Asp Pro Gly Asn Arg Pro His Leu Ile Arg Leu Phe Ser 
                85                  90                  95      


Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 
            100                 105                 110         


Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Pro Thr Ala Ala Ser 
        115                 120                 125             


Gly Gly Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg Ser 
    130                 135                 140                 


Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe 
145                 150                 155                 160 


Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe 
                165                 170                 175     


Phe Ser Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Ser 
            180                 185                 190         


Ser Glu Pro 
        195 


<210>  14
<211>  744
<212>  DNA
<213>  Homo sapiens

<400>  14
atggcaagct tatcgagacc ctctctgccc agctgcctct gctccttcct cctcctcctc       60

ctcctccaag tgtcttccag ctatgcaggg cagttcagag tgataggacc aagacaccct      120

atccgggctc tggtcgggga tgaagtggaa ttgccatgtc gcatatctcc tgggaagaac      180

gctacaggca tggaggtggg gtggtaccgc ccccccttct ctagggtggt tcatctctac      240

agaaatggca aggaccaaga tggagaccag gcacctgaat atcggggccg gacagagctg      300

ctgaaagatg ctattggtga gggaaaggtg actctcagga tccggaatgt aaggttctca      360

gatgaaggag gtttcacctg cttcttccga gatcattctt accaagagga ggcagcaatg      420

gaattgaaag tagaagatcc tttctactgg gtgagccctg gagtgctggt tctcctcgcg      480

gtgctgcctg tgctcctcct gcagatcact gttggcctcg tcttcctctg cctgcagtac      540

agactgagag gaaaacttcg agcagagata gagaatctcc accggacttt tgatccccac      600

tttctgaggg tgccctgctg gaagataacc ctgtttgtaa ttgtgccggt tcttggaccc      660

ttggttgcct tgatcatctg ctacaactgg ctacatcgaa gactagcagg gcaattcctt      720

gaagagctac gaaatccctt ctga                                             744


<210>  15
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ala Ser Leu Ser Arg Pro Ser Leu Pro Ser Cys Leu Cys Ser Phe 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Gln Val Ser Ser Ser Tyr Ala Gly Gln Phe 
            20                  25                  30          


Arg Val Ile Gly Pro Arg His Pro Ile Arg Ala Leu Val Gly Asp Glu 
        35                  40                  45              


Val Glu Leu Pro Cys Arg Ile Ser Pro Gly Lys Asn Ala Thr Gly Met 
    50                  55                  60                  


Glu Val Gly Trp Tyr Arg Pro Pro Phe Ser Arg Val Val His Leu Tyr 
65                  70                  75                  80  


Arg Asn Gly Lys Asp Gln Asp Gly Asp Gln Ala Pro Glu Tyr Arg Gly 
                85                  90                  95      


Arg Thr Glu Leu Leu Lys Asp Ala Ile Gly Glu Gly Lys Val Thr Leu 
            100                 105                 110         


Arg Ile Arg Asn Val Arg Phe Ser Asp Glu Gly Gly Phe Thr Cys Phe 
        115                 120                 125             


Phe Arg Asp His Ser Tyr Gln Glu Glu Ala Ala Met Glu Leu Lys Val 
    130                 135                 140                 


Glu Asp Pro Phe Tyr Trp Val Ser Pro Gly Val Leu Val Leu Leu Ala 
145                 150                 155                 160 


Val Leu Pro Val Leu Leu Leu Gln Ile Thr Val Gly Leu Val Phe Leu 
                165                 170                 175     


Cys Leu Gln Tyr Arg Leu Arg Gly Lys Leu Arg Ala Glu Ile Glu Asn 
            180                 185                 190         


Leu His Arg Thr Phe Asp Pro His Phe Leu Arg Val Pro Cys Trp Lys 
        195                 200                 205             


Ile Thr Leu Phe Val Ile Val Pro Val Leu Gly Pro Leu Val Ala Leu 
    210                 215                 220                 


Ile Ile Cys Tyr Asn Trp Leu His Arg Arg Leu Ala Gly Gln Phe Leu 
225                 230                 235                 240 


Glu Glu Leu Arg Asn Pro Phe 
                245         


<210>  16
<211>  915
<212>  DNA
<213>  Homo sapiens

<400>  16
atgggaaacc acgcaggcaa acgagaatta aatgccgaga aggccagtac gaatagtgaa       60

actaacagag gagaatctga aaaaaagaga aacctgggtg aactttcacg gacaacctca      120

gaggacaacg aagtgttcgg agaggcagat gcgaaccaga acaatgggac ctcctctcag      180

gacacagcgg tgactgactc caagcgcaca gcggacccga agaatgcctg gcaggatgcc      240

cacccagctg acccagggag ccgcccccac ttgatccgcc tcttttcccg agatgccccg      300

gggagggagg acaacacctt caaagacagg ccctctgagt ccgacgagct ccagaccatc      360

caagaagaca gtgcagccac ctccgagagc ctggatgtga tggcgtcaca gaagagaccc      420

tcccagaggc acggatccaa gtacctggcc acagcaagta ccatggacca tgccaggcat      480

ggcttcctcc caaggcacag agacacgggc atccttgact ccatcgggcg cttctttggc      540

ggtgacaggg gtgcgcccaa gcggggctct ggcaaggact cacaccaccc ggcaagaact      600

gctcactacg gctccctgcc ccagaagtca cacggccgga cccaagatga aaaccccgta      660

gtccacttct tcaagaacat tgtgacgcct cgcacaccac ccccgtcgca gggaaagggg      720

agaggactgt ccctgagcag atttagctgg ggggccgaag gccagagacc aggatttggc      780

tacggaggca gagcgtccga ctataaatcg gctcacaagg gattcaaggg agtcgatgcc      840

cagggcacgc tttccaaaat ttttaagctg ggaggaagag atagtcgctc tggatcaccc      900

atggctagac gctga                                                       915


<210>  17
<211>  304
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 
1               5                   10                  15      


Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 
            20                  25                  30          


Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 
        35                  40                  45              


Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 
    50                  55                  60                  


Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 
65                  70                  75                  80  


His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 
                85                  90                  95      


Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 
            100                 105                 110         


Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 
        115                 120                 125             


Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 
    130                 135                 140                 


Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 
145                 150                 155                 160 


Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 
                165                 170                 175     


Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 
            180                 185                 190         


Asp Ser His His Pro Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln 
        195                 200                 205             


Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro Val Val His Phe Phe 
    210                 215                 220                 


Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly 
225                 230                 235                 240 


Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg 
                245                 250                 255     


Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 
            260                 265                 270         


Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 
        275                 280                 285             


Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
    290                 295                 300                 


<210>  18
<211>  594
<212>  DNA
<213>  Homo sapiens

<400>  18
atggcgtcac agaagagacc ctcccagagg cacggatcca agtacctggc cacagcaagt       60

accatggacc atgccaggca tggcttcctc ccaaggcaca gagacacggg catccttgac      120

tccatcgggc gcttctttgg cggtgacagg ggtgcgccca agcggggctc tggcaaggta      180

ccctggctaa agccgggccg gagccctctg ccctctcatg cccgcagcca gcctgggctg      240

tgcaacatgt acaaggactc acaccacccg gcaagaactg ctcactacgg ctccctgccc      300

cagaagtcac acggccggac ccaagatgaa aaccccgtag tccacttctt caagaacatt      360

gtgacgcctc gcacaccacc cccgtcgcag ggaaagggga gaggactgtc cctgagcaga      420

tttagctggg gggccgaagg ccagagacca ggatttggct acggaggcag agcgtccgac      480

tataaatcgg ctcacaaggg attcaaggga gtcgatgccc agggcacgct ttccaaaatt      540

tttaagctgg gaggaagaga tagtcgctct ggatcaccca tggctagacg ctga            594


<210>  19
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 
    50                  55                  60                  


Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 
65                  70                  75                  80  


Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 
                85                  90                  95      


Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 
            100                 105                 110         


Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 
        115                 120                 125             


Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu Ser Arg Phe Ser Trp Gly 
    130                 135                 140                 


Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp 
145                 150                 155                 160 


Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr 
                165                 170                 175     


Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser 
            180                 185                 190         


Pro Met Ala Arg Arg 
        195         


<210>  20
<211>  561
<212>  DNA
<213>  Homo sapiens

<400>  20
atggcgtcac agaagagacc ctcccagagg cacggatcca agtacctggc cacagcaagt       60

accatggacc atgccaggca tggcttcctc ccaaggcaca gagacacggg catccttgac      120

tccatcgggc gcttctttgg cggtgacagg ggtgcgccca agcggggctc tggcaaggta      180

ccctggctaa agccgggccg gagccctctg ccctctcatg cccgcagcca gcctgggctg      240

tgcaacatgt acaaggactc acaccacccg gcaagaactg ctcactacgg ctccctgccc      300

cagaagtcac acggccggac ccaagatgaa aaccccgtag tccacttctt caagaacatt      360

gtgacgcctc gcacaccacc cccgtcgcag ggaaaggggg ccgaaggcca gagaccagga      420

tttggctacg gaggcagagc gtccgactat aaatcggctc acaagggatt caagggagtc      480

gatgcccagg gcacgctttc caaaattttt aagctgggag gaagagatag tcgctctgga      540

tcacccatgg ctagacgctg a                                                561


<210>  21
<211>  186
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Val Pro Trp Leu Lys 
    50                  55                  60                  


Pro Gly Arg Ser Pro Leu Pro Ser His Ala Arg Ser Gln Pro Gly Leu 
65                  70                  75                  80  


Cys Asn Met Tyr Lys Asp Ser His His Pro Ala Arg Thr Ala His Tyr 
                85                  90                  95      


Gly Ser Leu Pro Gln Lys Ser His Gly Arg Thr Gln Asp Glu Asn Pro 
            100                 105                 110         


Val Val His Phe Phe Lys Asn Ile Val Thr Pro Arg Thr Pro Pro Pro 
        115                 120                 125             


Ser Gln Gly Lys Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr Gly 
    130                 135                 140                 


Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly Val 
145                 150                 155                 160 


Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg Asp 
                165                 170                 175     


Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
            180                 185     


<210>  22
<211>  516
<212>  DNA
<213>  Homo sapiens

<400>  22
atggcgtcac agaagagacc ctcccagagg cacggatcca agtacctggc cacagcaagt       60

accatggacc atgccaggca tggcttcctc ccaaggcaca gagacacggg catccttgac      120

tccatcgggc gcttctttgg cggtgacagg ggtgcgccca agcggggctc tggcaaggac      180

tcacaccacc cggcaagaac tgctcactac ggctccctgc cccagaagtc acacggccgg      240

acccaagatg aaaaccccgt agtccacttc ttcaagaaca ttgtgacgcc tcgcacacca      300

cccccgtcgc agggaaaggg gagaggactg tccctgagca gatttagctg gggggccgaa      360

ggccagagac caggatttgg ctacggaggc agagcgtccg actataaatc ggctcacaag      420

ggattcaagg gagtcgatgc ccagggcacg ctttccaaaa tttttaagct gggaggaaga      480

gatagtcgct ctggatcacc catggctaga cgctga                                516


<210>  23
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro 
    50                  55                  60                  


Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg 
65                  70                  75                  80  


Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr 
                85                  90                  95      


Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Arg Gly Leu Ser Leu 
            100                 105                 110         


Ser Arg Phe Ser Trp Gly Ala Glu Gly Gln Arg Pro Gly Phe Gly Tyr 
        115                 120                 125             


Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His Lys Gly Phe Lys Gly 
    130                 135                 140                 


Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe Lys Leu Gly Gly Arg 
145                 150                 155                 160 


Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
                165                 170     


<210>  24
<211>  483
<212>  DNA
<213>  Homo sapiens

<400>  24
atggcgtcac agaagagacc ctcccagagg cacggatcca agtacctggc cacagcaagt       60

accatggacc atgccaggca tggcttcctc ccaaggcaca gagacacggg catccttgac      120

tccatcgggc gcttctttgg cggtgacagg ggtgcgccca agcggggctc tggcaaggac      180

tcacaccacc cggcaagaac tgctcactac ggctccctgc cccagaagtc acacggccgg      240

acccaagatg aaaaccccgt agtccacttc ttcaagaaca ttgtgacgcc tcgcacacca      300

cccccgtcgc agggaaaggg ggccgaaggc cagagaccag gatttggcta cggaggcaga      360

gcgtccgact ataaatcggc tcacaaggga ttcaagggag tcgatgccca gggcacgctt      420

tccaaaattt ttaagctggg aggaagagat agtcgctctg gatcacccat ggctagacgc      480

tga                                                                    483


<210>  25
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His Gly Ser Lys Tyr Leu 
1               5                   10                  15      


Ala Thr Ala Ser Thr Met Asp His Ala Arg His Gly Phe Leu Pro Arg 
            20                  25                  30          


His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly Arg Phe Phe Gly Gly 
        35                  40                  45              


Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys Asp Ser His His Pro 
    50                  55                  60                  


Ala Arg Thr Ala His Tyr Gly Ser Leu Pro Gln Lys Ser His Gly Arg 
65                  70                  75                  80  


Thr Gln Asp Glu Asn Pro Val Val His Phe Phe Lys Asn Ile Val Thr 
                85                  90                  95      


Pro Arg Thr Pro Pro Pro Ser Gln Gly Lys Gly Ala Glu Gly Gln Arg 
            100                 105                 110         


Pro Gly Phe Gly Tyr Gly Gly Arg Ala Ser Asp Tyr Lys Ser Ala His 
        115                 120                 125             


Lys Gly Phe Lys Gly Val Asp Ala Gln Gly Thr Leu Ser Lys Ile Phe 
    130                 135                 140                 


Lys Leu Gly Gly Arg Asp Ser Arg Ser Gly Ser Pro Met Ala Arg Arg 
145                 150                 155                 160 


<210>  26
<211>  594
<212>  DNA
<213>  Homo sapiens

<400>  26
atgggaaacc acgcaggcaa acgagaatta aatgccgaga aggccagtac gaatagtgaa       60

actaacagag gagaatctga aaaaaagaga aacctgggtg aactttcacg gacaacctca      120

gaggacaacg aagtgttcgg agaggcagat gcgaaccaga acaatgggac ctcctctcag      180

gacacagcgg tgactgactc caagcgcaca gcggacccga agaatgcctg gcaggatgcc      240

cacccagctg acccagggag ccgcccccac ttgatccgcc tcttttcccg agatgccccg      300

gggagggagg acaacacctt caaagacagg ccctctgagt ccgacgagct ccagaccatc      360

caagaagaca gtgcagccac ctccgagagc ctggatgtga tggcgtcaca gaagagaccc      420

tcccagaggc acggatccaa gtacctggcc acagcaagta ccatggacca tgccaggcat      480

ggcttcctcc caaggcacag agacacgggc atccttgact ccatcgggcg cttctttggc      540

ggtgacaggg gtgcgcccaa gcggggctct ggcaaggtga gctctgagga gtag            594


<210>  27
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Gly Asn His Ala Gly Lys Arg Glu Leu Asn Ala Glu Lys Ala Ser 
1               5                   10                  15      


Thr Asn Ser Glu Thr Asn Arg Gly Glu Ser Glu Lys Lys Arg Asn Leu 
            20                  25                  30          


Gly Glu Leu Ser Arg Thr Thr Ser Glu Asp Asn Glu Val Phe Gly Glu 
        35                  40                  45              


Ala Asp Ala Asn Gln Asn Asn Gly Thr Ser Ser Gln Asp Thr Ala Val 
    50                  55                  60                  


Thr Asp Ser Lys Arg Thr Ala Asp Pro Lys Asn Ala Trp Gln Asp Ala 
65                  70                  75                  80  


His Pro Ala Asp Pro Gly Ser Arg Pro His Leu Ile Arg Leu Phe Ser 
                85                  90                  95      


Arg Asp Ala Pro Gly Arg Glu Asp Asn Thr Phe Lys Asp Arg Pro Ser 
            100                 105                 110         


Glu Ser Asp Glu Leu Gln Thr Ile Gln Glu Asp Ser Ala Ala Thr Ser 
        115                 120                 125             


Glu Ser Leu Asp Val Met Ala Ser Gln Lys Arg Pro Ser Gln Arg His 
    130                 135                 140                 


Gly Ser Lys Tyr Leu Ala Thr Ala Ser Thr Met Asp His Ala Arg His 
145                 150                 155                 160 


Gly Phe Leu Pro Arg His Arg Asp Thr Gly Ile Leu Asp Ser Ile Gly 
                165                 170                 175     


Arg Phe Phe Gly Gly Asp Arg Gly Ala Pro Lys Arg Gly Ser Gly Lys 
            180                 185                 190         


Val Ser Ser Glu Glu 
        195         


<210>  28
<211>  834
<212>  DNA
<213>  Homo sapiens

<400>  28
atgggcttgt tagagtgctg tgcaagatgt ctggtagggg ccccctttgc ttccctggtg       60

gccactggat tgtgtttctt tggggtggca ctgttctgtg gctgtggaca tgaagccctc      120

actggcacag aaaagctaat tgagacctat ttctccaaaa actaccaaga ctatgagtat      180

ctcatcaatg tgatccatgc cttccagtat gtcatctatg gaactgcctc tttcttcttc      240

ctttatgggg ccctcctgct ggctgagggc ttctacacca ccggcgcagt caggcagatc      300

tttggcgact acaagaccac catctgcggc aagggcctga gcgcaacggt aacagggggc      360

cagaagggga ggggttccag aggccaacat caagctcatt ctttggagcg ggtgtgtcat      420

tgtttgggaa aatggctagg acatcccgac aagtttgtgg gcatcaccta tgccctgacc      480

gttgtgtggc tcctggtgtt tgcctgctct gctgtgcctg tgtacattta cttcaacacc      540

tggaccacct gccagtctat tgccttcccc agcaagacct ctgccagtat aggcagtctc      600

tgtgctgatg ccagaatgta tggtgttctc ccatggaatg ctttccctgg caaggtttgt      660

ggctccaacc ttctgtccat ctgcaaaaca gctgagttcc aaatgacctt ccacctgttt      720

attgctgcat ttgtgggggc tgcagctaca ctggtttccc tgctcacctt catgattgct      780

gccacttaca actttgccgt ccttaaactc atgggccgag gcaccaagtt ctga            834


<210>  29
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 
        115                 120                 125             


Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 
    130                 135                 140                 


Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 
145                 150                 155                 160 


Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 
                165                 170                 175     


Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
            180                 185                 190         


Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 
        195                 200                 205             


Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 
    210                 215                 220                 


Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 
225                 230                 235                 240 


Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 
                245                 250                 255     


Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 
            260                 265                 270         


Arg Gly Thr Lys Phe 
        275         


<210>  30
<211>  729
<212>  DNA
<213>  Homo sapiens

<400>  30
atgggcttgt tagagtgctg tgcaagatgt ctggtagggg ccccctttgc ttccctggtg       60

gccactggat tgtgtttctt tggggtggca ctgttctgtg gctgtggaca tgaagccctc      120

actggcacag aaaagctaat tgagacctat ttctccaaaa actaccaaga ctatgagtat      180

ctcatcaatg tgatccatgc cttccagtat gtcatctatg gaactgcctc tttcttcttc      240

ctttatgggg ccctcctgct ggctgagggc ttctacacca ccggcgcagt caggcagatc      300

tttggcgact acaagaccac catctgcggc aagggcctga gcgcaacgtt tgtgggcatc      360

acctatgccc tgaccgttgt gtggctcctg gtgtttgcct gctctgctgt gcctgtgtac      420

atttacttca acacctggac cacctgccag tctattgcct tccccagcaa gacctctgcc      480

agtataggca gtctctgtgc tgatgccaga atgtatggtg ttctcccatg gaatgctttc      540

cctggcaagg tttgtggctc caaccttctg tccatctgca aaacagctga gttccaaatg      600

accttccacc tgtttattgc tgcatttgtg ggggctgcag ctacactggt ttccctgctc      660

accttcatga ttgctgccac ttacaacttt gccgtcctta aactcatggg ccgaggcacc      720

aagttctga                                                              729


<210>  31
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Phe Val Gly Ile Thr Tyr Ala Leu Thr Val Val Trp 
        115                 120                 125             


Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile Tyr Phe Asn 
    130                 135                 140                 


Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala 
145                 150                 155                 160 


Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly Val Leu Pro 
                165                 170                 175     


Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu Leu Ser Ile 
            180                 185                 190         


Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe Ile Ala Ala 
        195                 200                 205             


Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr Phe Met Ile 
    210                 215                 220                 


Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly Arg Gly Thr 
225                 230                 235                 240 


Lys Phe 
        


<210>  32
<211>  834
<212>  DNA
<213>  Homo sapiens

<400>  32
atgggcttgt tagagtgctg tgcaagatgt ctggtagggg ccccctttgc ttccctggtg       60

gccactggat tgtgtttctt tggggtggca ctgttctgtg gctgtggaca tgaagccctc      120

actggcacag aaaagctaat tgagacctat ttctccaaaa actaccaaga ctatgagtat      180

ctcatcaatg tgatccatgc cttccagtat gtcatctatg gaactgcctc tttcttcttc      240

ctttatgggg ccctcctgct ggctgagggc ttctacacca ccggcgcagt caggcagatc      300

tttggcgact acaagaccac catctgcggc aagggcctga gcgcaacggt aacagggggc      360

cagaagggga ggggttccag aggccaacat caagctcatt ctttggagcg ggtgtgtcat      420

tgtttgggaa aatggctagg acatcccgac aagtttgtgg gcatcaccta tgccctgacc      480

gttgtgtggc tcctggtgtt tgcctgctct gctgtgcctg tgtacattta cttcaacacc      540

tggaccacct gccagtctat tgccttcccc agcaagacct ctgccagtat aggcagtctc      600

tgtgctgatg ccagaatgta tggtgttctc ccatggaatg ctttccctgg caaggtttgt      660

ggctccaacc ttctgtccat ctgcaaaaca gctgagttcc aaatgacctt ccacctgttt      720

attgctgcat ttgtgggggc tgcagctaca ctggtttccc tgctcacctt catgattgct      780

gccacttaca actttgccgt ccttaaactc atgggccgag gcaccaagtt ctga            834


<210>  33
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Gly Leu Leu Glu Cys Cys Ala Arg Cys Leu Val Gly Ala Pro Phe 
1               5                   10                  15      


Ala Ser Leu Val Ala Thr Gly Leu Cys Phe Phe Gly Val Ala Leu Phe 
            20                  25                  30          


Cys Gly Cys Gly His Glu Ala Leu Thr Gly Thr Glu Lys Leu Ile Glu 
        35                  40                  45              


Thr Tyr Phe Ser Lys Asn Tyr Gln Asp Tyr Glu Tyr Leu Ile Asn Val 
    50                  55                  60                  


Ile His Ala Phe Gln Tyr Val Ile Tyr Gly Thr Ala Ser Phe Phe Phe 
65                  70                  75                  80  


Leu Tyr Gly Ala Leu Leu Leu Ala Glu Gly Phe Tyr Thr Thr Gly Ala 
                85                  90                  95      


Val Arg Gln Ile Phe Gly Asp Tyr Lys Thr Thr Ile Cys Gly Lys Gly 
            100                 105                 110         


Leu Ser Ala Thr Val Thr Gly Gly Gln Lys Gly Arg Gly Ser Arg Gly 
        115                 120                 125             


Gln His Gln Ala His Ser Leu Glu Arg Val Cys His Cys Leu Gly Lys 
    130                 135                 140                 


Trp Leu Gly His Pro Asp Lys Phe Val Gly Ile Thr Tyr Ala Leu Thr 
145                 150                 155                 160 


Val Val Trp Leu Leu Val Phe Ala Cys Ser Ala Val Pro Val Tyr Ile 
                165                 170                 175     


Tyr Phe Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
            180                 185                 190         


Thr Ser Ala Ser Ile Gly Ser Leu Cys Ala Asp Ala Arg Met Tyr Gly 
        195                 200                 205             


Val Leu Pro Trp Asn Ala Phe Pro Gly Lys Val Cys Gly Ser Asn Leu 
    210                 215                 220                 


Leu Ser Ile Cys Lys Thr Ala Glu Phe Gln Met Thr Phe His Leu Phe 
225                 230                 235                 240 


Ile Ala Ala Phe Val Gly Ala Ala Ala Thr Leu Val Ser Leu Leu Thr 
                245                 250                 255     


Phe Met Ile Ala Ala Thr Tyr Asn Phe Ala Val Leu Lys Leu Met Gly 
            260                 265                 270         


Arg Gly Thr Lys Phe 
        275         


<210>  34
<211>  669
<212>  DNA
<213>  Homo sapiens

<400>  34
atggactatg agtatctcat caatgtgatc catgccttcc agtatgtcat ctatggaact       60

gcctctttct tcttccttta tggggccctc ctgctggctg agggcttcta caccaccggc      120

gcagtcaggc agatctttgg cgactacaag accaccatct gcggcaaggg cctgagcgca      180

acggtaacag ggggccagaa ggggaggggt tccagaggcc aacatcaagc tcattctttg      240

gagcgggtgt gtcattgttt gggaaaatgg ctaggacatc ccgacaagtt tgtgggcatc      300

acctatgccc tgaccgttgt gtggctcctg gtgtttgcct gctctgctgt gcctgtgtac      360

atttacttca acacctggac cacctgccag tctattgcct tccccagcaa gacctctgcc      420

agtataggca gtctctgtgc tgatgccaga atgtatggtg ttctcccatg gaatgctttc      480

cctggcaagg tttgtggctc caaccttctg tccatctgca aaacagctga gttccaaatg      540

accttccacc tgtttattgc tgcatttgtg ggggctgcag ctacactggt ttccctgctc      600

accttcatga ttgctgccac ttacaacttt gccgtcctta aactcatggg ccgaggcacc      660

aagttctga                                                              669


<210>  35
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Asp Tyr Glu Tyr Leu Ile Asn Val Ile His Ala Phe Gln Tyr Val 
1               5                   10                  15      


Ile Tyr Gly Thr Ala Ser Phe Phe Phe Leu Tyr Gly Ala Leu Leu Leu 
            20                  25                  30          


Ala Glu Gly Phe Tyr Thr Thr Gly Ala Val Arg Gln Ile Phe Gly Asp 
        35                  40                  45              


Tyr Lys Thr Thr Ile Cys Gly Lys Gly Leu Ser Ala Thr Val Thr Gly 
    50                  55                  60                  


Gly Gln Lys Gly Arg Gly Ser Arg Gly Gln His Gln Ala His Ser Leu 
65                  70                  75                  80  


Glu Arg Val Cys His Cys Leu Gly Lys Trp Leu Gly His Pro Asp Lys 
                85                  90                  95      


Phe Val Gly Ile Thr Tyr Ala Leu Thr Val Val Trp Leu Leu Val Phe 
            100                 105                 110         


Ala Cys Ser Ala Val Pro Val Tyr Ile Tyr Phe Asn Thr Trp Thr Thr 
        115                 120                 125             


Cys Gln Ser Ile Ala Phe Pro Ser Lys Thr Ser Ala Ser Ile Gly Ser 
    130                 135                 140                 


Leu Cys Ala Asp Ala Arg Met Tyr Gly Val Leu Pro Trp Asn Ala Phe 
145                 150                 155                 160 


Pro Gly Lys Val Cys Gly Ser Asn Leu Leu Ser Ile Cys Lys Thr Ala 
                165                 170                 175     


Glu Phe Gln Met Thr Phe His Leu Phe Ile Ala Ala Phe Val Gly Ala 
            180                 185                 190         


Ala Ala Thr Leu Val Ser Leu Leu Thr Phe Met Ile Ala Ala Thr Tyr 
        195                 200                 205             


Asn Phe Ala Val Leu Lys Leu Met Gly Arg Gly Thr Lys Phe 
    210                 215                 220         


<210>  36
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CD4 T cell epitope

<400>  36

Gly Arg Val Arg Val Asn Ser Ala Tyr 
1               5                   


<210>  37
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PLP peptide

<400>  37

Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
1               5                   10                  


