                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Tumor Suppressor And Oncogene Biomarkers Predictive Of 
       Anti-Immune Checkpoint Inhibitor Response

<130>  DFS-138.25

<140>  PCT/US2015/27515
<141>  2015-04-24

<150>  61/983,602
<151>  2014-04-24

<150>  62/012,689
<151>  2014-06-16

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  993
<212>  DNA
<213>  Homo sapiens

<400>  1
atgagcgcca agtccagaac catagggatt attggagctc ctttctcaaa gggacagcca       60

cgaggagggg tggaagaagg ccctacagta ttgagaaagg ctggtctgct tgagaaactt      120

aaagaacaag taactcaaaa ctttttaatt ttagagtgtg atgtgaagga ttatggggac      180

ctgccctttg ctgacatccc taatgacagt ccctttcaaa ttgtgaagaa tccaaggtct      240

gtgggaaaag caagcgagca gctggctggc aaggtggcag aagtcaagaa gaacggaaga      300

atcagcctgg tgctgggcgg agaccacagt ttggcaattg gaagcatctc tggccatgcc      360

agggtccacc ctgatcttgg agtcatctgg gtggatgctc acactgatat caacactcca      420

ctgacaacca caagtggaaa cttgcatgga caacctgtat ctttcctcct gaaggaacta      480

aaaggaaaga ttcccgatgt gccaggattc tcctgggtga ctccctgtat atctgccaag      540

gatattgtgt atattggctt gagagacgtg gaccctgggg aacactacat tttgaaaact      600

ctaggcatta aatacttttc aatgactgaa gtggacagac taggaattgg caaggtgatg      660

gaagaaacac tcagctatct actaggaaga aagaaaaggc caattcatct aagttttgat      720

gttgacggac tggacccatc tttcacacca gctactggca caccagtcgt gggaggtctg      780

acatacagag aaggtctcta catcacagaa gaaatctaca aaacagggct actctcagga      840

ttagatataa tggaagtgaa cccatccctg gggaagacac cagaagaagt aactcgaaca      900

gtgaacacag cagttgcaat aaccttggct tgtttcggac ttgctcggga gggtaatcac      960

aagcctattg actaccttaa cccacctaag taa                                   993


<210>  2
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser 
1               5                   10                  15      


Lys Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg 
            20                  25                  30          


Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Val Thr Gln Asn Phe 
        35                  40                  45              


Leu Ile Leu Glu Cys Asp Val Lys Asp Tyr Gly Asp Leu Pro Phe Ala 
    50                  55                  60                  


Asp Ile Pro Asn Asp Ser Pro Phe Gln Ile Val Lys Asn Pro Arg Ser 
65                  70                  75                  80  


Val Gly Lys Ala Ser Glu Gln Leu Ala Gly Lys Val Ala Glu Val Lys 
                85                  90                  95      


Lys Asn Gly Arg Ile Ser Leu Val Leu Gly Gly Asp His Ser Leu Ala 
            100                 105                 110         


Ile Gly Ser Ile Ser Gly His Ala Arg Val His Pro Asp Leu Gly Val 
        115                 120                 125             


Ile Trp Val Asp Ala His Thr Asp Ile Asn Thr Pro Leu Thr Thr Thr 
    130                 135                 140                 


Ser Gly Asn Leu His Gly Gln Pro Val Ser Phe Leu Leu Lys Glu Leu 
145                 150                 155                 160 


Lys Gly Lys Ile Pro Asp Val Pro Gly Phe Ser Trp Val Thr Pro Cys 
                165                 170                 175     


Ile Ser Ala Lys Asp Ile Val Tyr Ile Gly Leu Arg Asp Val Asp Pro 
            180                 185                 190         


Gly Glu His Tyr Ile Leu Lys Thr Leu Gly Ile Lys Tyr Phe Ser Met 
        195                 200                 205             


Thr Glu Val Asp Arg Leu Gly Ile Gly Lys Val Met Glu Glu Thr Leu 
    210                 215                 220                 


Ser Tyr Leu Leu Gly Arg Lys Lys Arg Pro Ile His Leu Ser Phe Asp 
225                 230                 235                 240 


Val Asp Gly Leu Asp Pro Ser Phe Thr Pro Ala Thr Gly Thr Pro Val 
                245                 250                 255     


Val Gly Gly Leu Thr Tyr Arg Glu Gly Leu Tyr Ile Thr Glu Glu Ile 
            260                 265                 270         


Tyr Lys Thr Gly Leu Leu Ser Gly Leu Asp Ile Met Glu Val Asn Pro 
        275                 280                 285             


Ser Leu Gly Lys Thr Pro Glu Glu Val Thr Arg Thr Val Asn Thr Ala 
    290                 295                 300                 


Val Ala Ile Thr Leu Ala Cys Phe Gly Leu Ala Arg Glu Gly Asn His 
305                 310                 315                 320 


Lys Pro Ile Asp Tyr Leu Asn Pro Pro Lys 
                325                 330 


<210>  3
<211>  969
<212>  DNA
<213>  Homo sapiens

<400>  3
atgagcgcca agtccagaac catagggatt attggagctc ctttctcaaa gggacagcca       60

cgaggagggg tggaagaagg ccctacagta ttgagaaagg ctggtctgct tgagaaactt      120

aaagaacaag agtgtgatgt gaaggattat ggggacctgc cctttgctga catccctaat      180

gacagtccct ttcaaattgt gaagaatcca aggtctgtgg gaaaagcaag cgagcagctg      240

gctggcaagg tggcagaagt caagaagaac ggaagaatca gcctggtgct gggcggagac      300

cacagtttgg caattggaag catctctggc catgccaggg tccaccctga tcttggagtc      360

atctgggtgg atgctcacac tgatatcaac actccactga caaccacaag tggaaacttg      420

catggacaac ctgtatcttt cctcctgaag gaactaaaag gaaagattcc cgatgtgcca      480

ggattctcct gggtgactcc ctgtatatct gccaaggata ttgtgtatat tggcttgaga      540

gacgtggacc ctggggaaca ctacattttg aaaactctag gcattaaata cttttcaatg      600

actgaagtgg acagactagg aattggcaag gtgatggaag aaacactcag ctatctacta      660

ggaagaaaga aaaggccaat tcatctaagt tttgatgttg acggactgga cccatctttc      720

acaccagcta ctggcacacc agtcgtggga ggtctgacat acagagaagg tctctacatc      780

acagaagaaa tctacaaaac agggctactc tcaggattag atataatgga agtgaaccca      840

tccctgggga agacaccaga agaagtaact cgaacagtga acacagcagt tgcaataacc      900

ttggcttgtt tcggacttgc tcgggagggt aatcacaagc ctattgacta ccttaaccca      960

cctaagtaa                                                              969


<210>  4
<211>  322
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Ala Lys Ser Arg Thr Ile Gly Ile Ile Gly Ala Pro Phe Ser 
1               5                   10                  15      


Lys Gly Gln Pro Arg Gly Gly Val Glu Glu Gly Pro Thr Val Leu Arg 
            20                  25                  30          


Lys Ala Gly Leu Leu Glu Lys Leu Lys Glu Gln Glu Cys Asp Val Lys 
        35                  40                  45              


Asp Tyr Gly Asp Leu Pro Phe Ala Asp Ile Pro Asn Asp Ser Pro Phe 
    50                  55                  60                  


Gln Ile Val Lys Asn Pro Arg Ser Val Gly Lys Ala Ser Glu Gln Leu 
65                  70                  75                  80  


Ala Gly Lys Val Ala Glu Val Lys Lys Asn Gly Arg Ile Ser Leu Val 
                85                  90                  95      


Leu Gly Gly Asp His Ser Leu Ala Ile Gly Ser Ile Ser Gly His Ala 
            100                 105                 110         


Arg Val His Pro Asp Leu Gly Val Ile Trp Val Asp Ala His Thr Asp 
        115                 120                 125             


Ile Asn Thr Pro Leu Thr Thr Thr Ser Gly Asn Leu His Gly Gln Pro 
    130                 135                 140                 


Val Ser Phe Leu Leu Lys Glu Leu Lys Gly Lys Ile Pro Asp Val Pro 
145                 150                 155                 160 


Gly Phe Ser Trp Val Thr Pro Cys Ile Ser Ala Lys Asp Ile Val Tyr 
                165                 170                 175     


Ile Gly Leu Arg Asp Val Asp Pro Gly Glu His Tyr Ile Leu Lys Thr 
            180                 185                 190         


Leu Gly Ile Lys Tyr Phe Ser Met Thr Glu Val Asp Arg Leu Gly Ile 
        195                 200                 205             


Gly Lys Val Met Glu Glu Thr Leu Ser Tyr Leu Leu Gly Arg Lys Lys 
    210                 215                 220                 


Arg Pro Ile His Leu Ser Phe Asp Val Asp Gly Leu Asp Pro Ser Phe 
225                 230                 235                 240 


Thr Pro Ala Thr Gly Thr Pro Val Val Gly Gly Leu Thr Tyr Arg Glu 
                245                 250                 255     


Gly Leu Tyr Ile Thr Glu Glu Ile Tyr Lys Thr Gly Leu Leu Ser Gly 
            260                 265                 270         


Leu Asp Ile Met Glu Val Asn Pro Ser Leu Gly Lys Thr Pro Glu Glu 
        275                 280                 285             


Val Thr Arg Thr Val Asn Thr Ala Val Ala Ile Thr Leu Ala Cys Phe 
    290                 295                 300                 


Gly Leu Ala Arg Glu Gly Asn His Lys Pro Ile Asp Tyr Leu Asn Pro 
305                 310                 315                 320 


Pro Lys 
        


<210>  5
<211>  570
<212>  DNA
<213>  Homo sapiens

<400>  5
atgactgaat ataaacttgt ggtagttgga gctggtggcg taggcaagag tgccttgacg       60

atacagctaa ttcagaatca ttttgtggac gaatatgatc caacaataga ggattcctac      120

aggaagcaag tagtaattga tggagaaacc tgtctcttgg atattctcga cacagcaggt      180

caagaggagt acagtgcaat gagggaccag tacatgagga ctggggaggg ctttctttgt      240

gtatttgcca taaataatac taaatcattt gaagatattc accattatag agaacaaatt      300

aaaagagtta aggactctga agatgtacct atggtcctag taggaaataa atgtgatttg      360

ccttctagaa cagtagacac aaaacaggct caggacttag caagaagtta tggaattcct      420

tttattgaaa catcagcaaa gacaagacag agagtggagg atgcttttta tacattggtg      480

agggagatcc gacaatacag attgaaaaaa atcagcaaag aagaaaagac tcctggctgt      540

gtgaaaatta aaaaatgcat tataatgtaa                                       570


<210>  6
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Arg Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Leu Lys Lys Ile Ser Lys Glu Glu Lys 
                165                 170                 175     


Thr Pro Gly Cys Val Lys Ile Lys Lys Cys Ile Ile Met 
            180                 185                 


<210>  7
<211>  567
<212>  DNA
<213>  Homo sapiens

<400>  7
atgactgaat ataaacttgt ggtagttgga gctggtggcg taggcaagag tgccttgacg       60

atacagctaa ttcagaatca ttttgtggac gaatatgatc caacaataga ggattcctac      120

aggaagcaag tagtaattga tggagaaacc tgtctcttgg atattctcga cacagcaggt      180

caagaggagt acagtgcaat gagggaccag tacatgagga ctggggaggg ctttctttgt      240

gtatttgcca taaataatac taaatcattt gaagatattc accattatag agaacaaatt      300

aaaagagtta aggactctga agatgtacct atggtcctag taggaaataa atgtgatttg      360

ccttctagaa cagtagacac aaaacaggct caggacttag caagaagtta tggaattcct      420

tttattgaaa catcagcaaa gacaagacag ggtgttgatg atgccttcta tacattagtt      480

cgagaaattc gaaaacataa agaaaagatg agcaaagatg gtaaaaagaa gaaaaagaag      540

tcaaagacaa agtgtgtaat tatgtaa                                          567


<210>  8
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys 
                165                 170                 175     


Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met 
            180                 185             


<210>  9
<211>  570
<212>  DNA
<213>  Homo sapiens

<400>  9
atgactgagt acaaactggt ggtggttgga gcaggtggtg ttgggaaaag cgcactgaca       60

atccagctaa tccagaacca ctttgtagat gaatatgatc ccaccataga ggattcttac      120

agaaaacaag tggttataga tggtgaaacc tgtttgttgg acatactgga tacagctgga      180

caagaagagt acagtgccat gagagaccaa tacatgagga caggcgaagg cttcctctgt      240

gtatttgcca tcaataatag caagtcattt gcggatatta acctctacag ggagcagatt      300

aagcgagtaa aagactcgga tgatgtacct atggtgctag tgggaaacaa gtgtgatttg      360

ccaacaagga cagttgatac aaaacaagcc cacgaactgg ccaagagtta cgggattcca      420

ttcattgaaa cctcagccaa gaccagacag ggtgttgaag atgcttttta cacactggta      480

agagaaatac gccagtaccg aatgaaaaaa ctcaacagca gtgatgatgg gactcagggt      540

tgtatgggat tgccatgtgt ggtgatgtaa                                       570


<210>  10
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys 
        115                 120                 125             


Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp 
                165                 170                 175     


Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met 
            180                 185                 


<210>  11
<211>  570
<212>  DNA
<213>  Homo sapiens

<400>  11
atgacggaat ataagctggt ggtggtgggc gccggcggtg tgggcaagag tgcgctgacc       60

atccagctga tccagaacca ttttgtggac gaatacgacc ccactataga ggattcctac      120

cggaagcagg tggtcattga tggggagacg tgcctgttgg acatcctgga taccgccggc      180

caggaggagt acagcgccat gcgggaccag tacatgcgca ccggggaggg cttcctgtgt      240

gtgtttgcca tcaacaacac caagtctttt gaggacatcc accagtacag ggagcagatc      300

aaacgggtga aggactcgga tgacgtgccc atggtgctgg tggggaacaa gtgtgacctg      360

gctgcacgca ctgtggaatc tcggcaggct caggacctcg cccgaagcta cggcatcccc      420

tacatcgaga cctcggccaa gacccggcag ggagtggagg atgccttcta cacgttggtg      480

cgtgagatcc ggcagcacaa gctgcggaag ctgaaccctc ctgatgagag tggccccggc      540

tgcatgagct gcaagtgtgt gctctcctga                                       570


<210>  12
<211>  570
<212>  DNA
<213>  Homo sapiens

<400>  12
atgacggaat ataagctggt ggtggtgggc gccggcggtg tgggcaagag tgcgctgacc       60

atccagctga tccagaacca ttttgtggac gaatacgacc ccactataga ggattcctac      120

cggaagcagg tggtcattga tggggagacg tgcctgttgg acatcctgga taccgccggc      180

caggaggagt acagcgccat gcgggaccag tacatgcgca ccggggaggg cttcctgtgt      240

gtgtttgcca tcaacaacac caagtctttt gaggacatcc accagtacag ggagcagatc      300

aaacgggtga aggactcgga tgacgtgccc atggtgctgg tggggaacaa gtgtgacctg      360

gctgcacgca ctgtggaatc tcggcaggct caggacctcg cccgaagcta cggcatcccc      420

tacatcgaga cctcggccaa gacccggcag ggagtggagg atgccttcta cacgttggtg      480

cgtgagatcc ggcagcacaa gctgcggaag ctgaaccctc ctgatgagag tggccccggc      540

tgcatgagct gcaagtgtgt gctctcctga                                       570


<210>  13
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val 
145                 150                 155                 160 


Arg Glu Ile Arg Gln His Lys Leu Arg Lys Leu Asn Pro Pro Asp Glu 
                165                 170                 175     


Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
            180                 185                 


<210>  14
<211>  513
<212>  DNA
<213>  Homo sapiens

<400>  14
atgacggaat ataagctggt ggtggtgggc gccggcggtg tgggcaagag tgcgctgacc       60

atccagctga tccagaacca ttttgtggac gaatacgacc ccactataga ggattcctac      120

cggaagcagg tggtcattga tggggagacg tgcctgttgg acatcctgga taccgccggc      180

caggaggagt acagcgccat gcgggaccag tacatgcgca ccggggaggg cttcctgtgt      240

gtgtttgcca tcaacaacac caagtctttt gaggacatcc accagtacag ggagcagatc      300

aaacgggtga aggactcgga tgacgtgccc atggtgctgg tggggaacaa gtgtgacctg      360

gctgcacgca ctgtggaatc tcggcaggct caggacctcg cccgaagcta cggcatcccc      420

tacatcgaga cctcggccaa gacccggcag ggcagccgct ctggctctag ctccagctcc      480

gggaccctct gggacccccc gggacccatg tga                                   513


<210>  15
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys 
1               5                   10                  15      


Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr 
            20                  25                  30          


Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly 
        35                  40                  45              


Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr 
    50                  55                  60                  


Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys 
65                  70                  75                  80  


Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His Gln Tyr 
                85                  90                  95      


Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val 
            100                 105                 110         


Leu Val Gly Asn Lys Cys Asp Leu Ala Ala Arg Thr Val Glu Ser Arg 
        115                 120                 125             


Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Tyr Ile Glu Thr 
    130                 135                 140                 


Ser Ala Lys Thr Arg Gln Gly Ser Arg Ser Gly Ser Ser Ser Ser Ser 
145                 150                 155                 160 


Gly Thr Leu Trp Asp Pro Pro Gly Pro Met 
                165                 170 


<210>  16
<211>  1302
<212>  DNA
<213>  Homo sapiens

<400>  16
atggaggtgg tggacccgca gcagctgggc atgttcacgg agggcgagct gatgtcggtg       60

ggtatggaca cgttcatcca ccgcatcgac tccaccgagg tcatctacca gccgcgccgc      120

aagcgggcca agctcatcgg caagtacctg atgggggacc tgctggggga aggctcttac      180

ggcaaggtga aggaggtgct ggactcggag acgctgtgca ggagggccgt caagatcctc      240

aagaagaaga agttgcgaag gatccccaac ggggaggcca acgtgaagaa ggaaattcaa      300

ctactgagga ggttacggca caaaaatgtc atccagctgg tggatgtgtt atacaacgaa      360

gagaagcaga aaatgtatat ggtgatggag tactgcgtgt gtggcatgca ggaaatgctg      420

gacagcgtgc cggagaagcg tttcccagtg tgccaggccc acgggtactt ctgtcagctg      480

attgacggcc tggagtacct gcatagccag ggcattgtgc acaaggacat caagccgggg      540

aacctgctgc tcaccaccgg tggcaccctc aaaatctccg acctgggcgt ggccgaggca      600

ctgcacccgt tcgcggcgga cgacacctgc cggaccagcc agggctcccc ggctttccag      660

ccgcccgaga ttgccaacgg cctggacacc ttctccggct tcaaggtgga catctggtcg      720

gctggggtca ccctctacaa catcaccacg ggtctgtacc ccttcgaagg ggacaacatc      780

tacaagttgt ttgagaacat cgggaagggg agctacgcca tcccgggcga ctgtggcccc      840

ccgctctctg acctgctgaa agggatgctt gagtacgaac cggccaagag gttctccatc      900

cggcagatcc ggcagcacag ctggttccgg aagaaacatc ctccggctga agcaccagtg      960

cccatcccac cgagcccaga caccaaggac cggtggcgca gcatgactgt ggtgccgtac     1020

ttggaggacc tgcacggcgc ggacgaggac gaggacctct tcgacatcga ggatgacatc     1080

atctacactc aggacttcac ggtgcccgga caggtcccag aagaggaggc cagtcacaat     1140

ggacagcgcc ggggcctccc caaggccgtg tgtatgaacg gcacagaggc ggcgcagctg     1200

agcaccaaat ccagggcgga gggccgggcc cccaaccctg cccgcaaggc ctgctccgcc     1260

agcagcaaga tccgccggct gtcggcctgc aagcagcagt ga                        1302


<210>  17
<211>  433
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Glu Val Val Asp Pro Gln Gln Leu Gly Met Phe Thr Glu Gly Glu 
1               5                   10                  15      


Leu Met Ser Val Gly Met Asp Thr Phe Ile His Arg Ile Asp Ser Thr 
            20                  25                  30          


Glu Val Ile Tyr Gln Pro Arg Arg Lys Arg Ala Lys Leu Ile Gly Lys 
        35                  40                  45              


Tyr Leu Met Gly Asp Leu Leu Gly Glu Gly Ser Tyr Gly Lys Val Lys 
    50                  55                  60                  


Glu Val Leu Asp Ser Glu Thr Leu Cys Arg Arg Ala Val Lys Ile Leu 
65                  70                  75                  80  


Lys Lys Lys Lys Leu Arg Arg Ile Pro Asn Gly Glu Ala Asn Val Lys 
                85                  90                  95      


Lys Glu Ile Gln Leu Leu Arg Arg Leu Arg His Lys Asn Val Ile Gln 
            100                 105                 110         


Leu Val Asp Val Leu Tyr Asn Glu Glu Lys Gln Lys Met Tyr Met Val 
        115                 120                 125             


Met Glu Tyr Cys Val Cys Gly Met Gln Glu Met Leu Asp Ser Val Pro 
    130                 135                 140                 


Glu Lys Arg Phe Pro Val Cys Gln Ala His Gly Tyr Phe Cys Gln Leu 
145                 150                 155                 160 


Ile Asp Gly Leu Glu Tyr Leu His Ser Gln Gly Ile Val His Lys Asp 
                165                 170                 175     


Ile Lys Pro Gly Asn Leu Leu Leu Thr Thr Gly Gly Thr Leu Lys Ile 
            180                 185                 190         


Ser Asp Leu Gly Val Ala Glu Ala Leu His Pro Phe Ala Ala Asp Asp 
        195                 200                 205             


Thr Cys Arg Thr Ser Gln Gly Ser Pro Ala Phe Gln Pro Pro Glu Ile 
    210                 215                 220                 


Ala Asn Gly Leu Asp Thr Phe Ser Gly Phe Lys Val Asp Ile Trp Ser 
225                 230                 235                 240 


Ala Gly Val Thr Leu Tyr Asn Ile Thr Thr Gly Leu Tyr Pro Phe Glu 
                245                 250                 255     


Gly Asp Asn Ile Tyr Lys Leu Phe Glu Asn Ile Gly Lys Gly Ser Tyr 
            260                 265                 270         


Ala Ile Pro Gly Asp Cys Gly Pro Pro Leu Ser Asp Leu Leu Lys Gly 
        275                 280                 285             


Met Leu Glu Tyr Glu Pro Ala Lys Arg Phe Ser Ile Arg Gln Ile Arg 
    290                 295                 300                 


Gln His Ser Trp Phe Arg Lys Lys His Pro Pro Ala Glu Ala Pro Val 
305                 310                 315                 320 


Pro Ile Pro Pro Ser Pro Asp Thr Lys Asp Arg Trp Arg Ser Met Thr 
                325                 330                 335     


Val Val Pro Tyr Leu Glu Asp Leu His Gly Ala Asp Glu Asp Glu Asp 
            340                 345                 350         


Leu Phe Asp Ile Glu Asp Asp Ile Ile Tyr Thr Gln Asp Phe Thr Val 
        355                 360                 365             


Pro Gly Gln Val Pro Glu Glu Glu Ala Ser His Asn Gly Gln Arg Arg 
    370                 375                 380                 


Gly Leu Pro Lys Ala Val Cys Met Asn Gly Thr Glu Ala Ala Gln Leu 
385                 390                 395                 400 


Ser Thr Lys Ser Arg Ala Glu Gly Arg Ala Pro Asn Pro Ala Arg Lys 
                405                 410                 415     


Ala Cys Ser Ala Ser Ser Lys Ile Arg Arg Leu Ser Ala Cys Lys Gln 
            420                 425                 430         


Gln 
    


<210>  18
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400 


Thr Lys Val 
            


<210>  19
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Thr Ala Ile Ile Lys Glu Ile Val Ser Arg Asn Lys Arg Arg Tyr 
1               5                   10                  15      


Gln Glu Asp Gly Phe Asp Leu Asp Leu Thr Tyr Ile Tyr Pro Asn Ile 
            20                  25                  30          


Ile Ala Met Gly Phe Pro Ala Glu Arg Leu Glu Gly Val Tyr Arg Asn 
        35                  40                  45              


Asn Ile Asp Asp Val Val Arg Phe Leu Asp Ser Lys His Lys Asn His 
    50                  55                  60                  


Tyr Lys Ile Tyr Asn Leu Cys Ala Glu Arg His Tyr Asp Thr Ala Lys 
65                  70                  75                  80  


Phe Asn Cys Arg Val Ala Gln Tyr Pro Phe Glu Asp His Asn Pro Pro 
                85                  90                  95      


Gln Leu Glu Leu Ile Lys Pro Phe Cys Glu Asp Leu Asp Gln Trp Leu 
            100                 105                 110         


Ser Glu Asp Asp Asn His Val Ala Ala Ile His Cys Lys Ala Gly Lys 
        115                 120                 125             


Gly Arg Thr Gly Val Met Ile Cys Ala Tyr Leu Leu His Arg Gly Lys 
    130                 135                 140                 


Phe Leu Lys Ala Gln Glu Ala Leu Asp Phe Tyr Gly Glu Val Arg Thr 
145                 150                 155                 160 


Arg Asp Lys Lys Gly Val Thr Ile Pro Ser Gln Arg Arg Tyr Val Tyr 
                165                 170                 175     


Tyr Tyr Ser Tyr Leu Leu Lys Asn His Leu Asp Tyr Arg Pro Val Ala 
            180                 185                 190         


Leu Leu Phe His Lys Met Met Phe Glu Thr Ile Pro Met Phe Ser Gly 
        195                 200                 205             


Gly Thr Cys Asn Pro Gln Phe Val Val Cys Gln Leu Lys Val Lys Ile 
    210                 215                 220                 


Tyr Ser Ser Asn Ser Gly Pro Thr Arg Arg Glu Asp Lys Phe Met Tyr 
225                 230                 235                 240 


Phe Glu Phe Pro Gln Pro Leu Pro Val Cys Gly Asp Ile Lys Val Glu 
                245                 250                 255     


Phe Phe His Lys Gln Asn Lys Met Leu Lys Lys Asp Lys Met Phe His 
            260                 265                 270         


Phe Trp Val Asn Thr Phe Phe Ile Pro Gly Pro Glu Glu Thr Ser Glu 
        275                 280                 285             


Lys Val Glu Asn Gly Ser Leu Cys Asp Gln Glu Ile Asp Ser Ile Cys 
    290                 295                 300                 


Ser Ile Glu Arg Ala Asp Asn Asp Lys Glu Tyr Leu Val Leu Thr Leu 
305                 310                 315                 320 


Thr Lys Asn Asp Leu Asp Lys Ala Asn Lys Asp Lys Ala Asn Arg Tyr 
                325                 330                 335     


Phe Ser Pro Asn Phe Lys Val Lys Leu Tyr Phe Thr Lys Thr Val Glu 
            340                 345                 350         


Glu Pro Ser Asn Pro Glu Ala Ser Ser Ser Thr Ser Val Thr Pro Asp 
        355                 360                 365             


Val Ser Asp Asn Glu Pro Asp His Tyr Arg Tyr Ser Asp Thr Thr Asp 
    370                 375                 380                 


Ser Asp Pro Glu Asn Glu Pro Phe Asp Glu Asp Gln His Thr Gln Ile 
385                 390                 395                 400 


Thr Lys Val