                         SEQUENCE LISTING

<110>  University of Pittsburgh - Of the Commonwealth System of 
       Higher Education
       Gittes, George
       Guo, Ping
       Xiao , Xiangwei
 
<120>  ENDOGENOUS NEOGENESIS OF BETA CELLS

<130>  8123-92873-02

<150>  61/983,295
<151>  2014-04-23

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  459
<212>  DNA
<213>  Homo sapiens

<400>  1
aaaaaatacc agataatttc ctgttagcat cagctatctt ggatgtttaa tcttcatttt       60

gctccatcct ttctgcctga attccattta ttaaaacaga acacataggg gtttaatcaa      120

tatccttaaa ttttccacaa acataacata aataaactcc acgttgtgag gaagagagga      180

tttttaatac atatgtgttg aatgaatgat cattatttag ataaatgaat gactgaagtg      240

attgttatat tcaggtaaat tcatcatggc taggtagcaa accaaagact tgtaagaacc      300

tcaaatgagg acatgcacaa aacagggatg gccatgggct acgtaatttc aaggtctttt      360

gtcttcaacg tcaaaattca ctttagagaa cttaagtgat tttcatgcgt gattgaaagt      420

agaaggtgga tttccaagct gctctctcca ttcccaacc                             459


<210>  2
<211>  1243
<212>  DNA
<213>  Homo sapiens

<400>  2
tcagtgacat catgcggttg gttatattag aatattggaa tctagttagg aaatgttgtg       60

atgagtttgc aatatggaat aaaattttta ttttagaaaa gacatttacc aacccctctc      120

attttacaaa taaggaggca gagacacaaa gagaatgcgt gacttgacca aggtcacaca      180

gctggtcaat aacagcaaaa ctaaaatcaa attatgccaa cactacttct tatgctgtct      240

ttccagatta tttaccattt ttctatttct ctacagtgac cagaatcatt tctgctaaat      300

gtcacagatc attaaagcct gtgtgtccag tcacaaaact caggaaacgt gaaaatatgc      360

atctcatctc aacagttttc ctcatatctc attcttttgt aacttagtac cccactctct      420

tatcagtaaa attagatttt aaatatatat tagaaggaaa aaaataccag ataatttcct      480

gttagcatca gctatcttgg atgtttaatc ttcattttgc tccatccttt ctgcctgaat      540

tccatttatt aaaacagaac acataggggt ttaatcaata tccttaaatt ttccacaaac      600

ataacataaa taaactccac gttgtgagga agagaggatt tttaatacat atgtgttgaa      660

tgaatgatca ttatttagat aaatgaatga ctgaagtgat tgttatattc aggtaaattc      720

atcatggcta ggtagcaaac caaagacttg taagaacctc aaatgaggac atgcacaaaa      780

cagggatggc catgggctac gtaatttcaa ggtcttttgt cttcaacgtc aaaattcact      840

ttagagaact taagtgattt tcatgcgtga ttgaaagtag aaggtggatt tccaagctgc      900

tctctccatt cccaaccaaa aaaaaaaaaa aaagatacaa gagtgcataa aaagtttcca      960

ggtctctaag gtctctcacc caatataagc atagaatgca gatgagcaaa gtgagtggga     1020

gagggaagtc atttgtaaca aaaactcatt atttacagat gagaaattta tattgtcagc     1080

gtaatatctg tgaggctaaa cagagctgga gagtatataa aagcagtgcg ccttggtgca     1140

gaagtacaga gcttaggaca cagagcacat caaaagttcc caaagagggc ttgctctctc     1200

ttcacctgct ctgttctaca gcacactacc agaaggtaag atg                       1243


<210>  3
<211>  461
<212>  DNA
<213>  Mus musculus

<400>  3
gagatatagc caaataccaa atcaagggat aagaccctca aatgagacta ggctcatttg       60

acgtcaaaat tcacttgaga gaactttagc agtttttcgt gcctgactga gaccgaaggg      120

tggatctcca aactgccctt tccattccca aacagaaagg cacaagagta aataaaatgt      180

ttccgggcct ctgcggtctc aacccggtat cagcgtaaaa agcagatgag caaagtgagt      240

gggcgagtga aatcatttga acaaaacccc attatttaca gatgagaaat ttatattgtc      300

agcgtaatat ctgcaaggct aaacagcctg gagagcatat aaaagcacag caccctggtg      360

cagaagggca gagcttgggc ccaggacaca ctcaaagttc ccaaggggac tccctctgtc      420

tacacctgtt cgcagctcag gctcacaagg cagaaaaaaa a                          461


<210>  4
<211>  2520
<212>  DNA
<213>  Homo sapiens

<400>  4
tagccaaaaa gtgggaaatt ataacaatac ttgacggccc cacttaggaa aaaaaacagt       60

ccaggtttgg agttaaattt tggggtctga ctggctgtgg ggtttggggc cagtgatttg      120

acatctctga gcagatttca gaccctgaat ctgtaaaatg ggttgttgtg gggatttagt      180

gaggtgactg agctggcagc actttggaaa atgtgaggct ttacaaatga agctggtttt      240

tagcacttcc ttggaatggg ggctctgaga tggggaggga aatggatact ggaaaccggc      300

acccccctca acatttcccc tgaacctagg cacatgagtc cattctgcat cctatgcacc      360

caccaaatgg gtttctccaa gcctggcacc ccactccttt ccaccttgcc tgaggaccct      420

gaggcccctt ccctcttccc accttgttct agttgcaagc tgcagaggat ggcctgagtt      480

tccattcttc agcctggagg ctctggctgt agcctcagtc ttccagctgc agcctcaatc      540

ttctgcccca agagaatccg ttggatgatt tgggttgatc tttgggaggc aggagagcta      600

gttccaaggc ctgtgaccaa aacctttcag tcactctcga gtcccagaac cccatctttc      660

ttgaaccaag cctgctctgg tgcccaaagg gaaggggtgt cagtgatggg ggcccacagg      720

agacttttac tgtggtccag ttttatctgt tatgctgctg gtctggcacc cacagaactg      780

ccctgtcccc ctcccgtctc tggcctcagt actggcgttg ccagtatgag gagacagtga      840

gaggaggggt gagggcttcg gagtgagaga ggctgacagg aggcggggac tctggggggc      900

tgaggactat aaagcggccc agccgagggc aggggcccat ccggcctgag gcaggtgctc      960

gcttggtcta gtgcccattt actctggact ccgggtaagt gggctcacgc ctgcctgggg     1020

ctctgggggc ctcccccagg ctggggcctg ggatggagag gaggtggtgc tttgcagggc     1080

caggggcctt gggaggccta aggtcctgct tgggtcttgc tttctgcatc tggacagacc     1140

tgtcacgcta gaagagccgt ctgctgactg cacgtgtgtg tgcacactcg tgtgcatggc     1200

ctgtgaactg gaatgtgtga ctgtgacctt gtgagtgaac tggggtccct gtgtgagtgc     1260

ctttgctggt ctgtgcagga cgacatggac aatagcgtct tctccaggac cgatatctgt     1320

gtctctatcg cagggtggag ggccagcacc cacaaggcca tggtttctgt ccttggcttc     1380

ccgagttcat tctgtgtccc ccaccctgtg ggtgacctgc atgcccttat tcccactagc     1440

tgctgcctcc tgggagccat gaggccctag atgtcatcag tcccgtgtct ccaggactca     1500

catccccatt ttaactaact tgcgaggccc tggcttgctg ggctgctcac aggacaggct     1560

gtccgtgcct tcagagcagt gtctaggagg tggagtggcc agcttggagt ggccctttgc     1620

tctgccccct tgtccccaag cttggagaaa tggatgatgg gctaaggggc tggatagttg     1680

ggccctgctt cctaggcacg ggaaaatctg caggcccggg cactccacct cccctctgct     1740

tgctcctcag atggctgccg cacgcctctg cctctccctg ctgctcctgt ccacctgcgt     1800

ggctctgtta ctacagccac tgctgggtgc ccagggagcc ccactggagc cagtgtaccc     1860

aggggacaat gccacaccag agcagatggc ccagtatgca gctgatctcc gtagatacat     1920

caacatgctg accaggccta ggtgtgtgcc acagttgggg agagagatcc cagcccctgg     1980

gaccctgggc ccactccaca ttcctggcca caccctatcc ccagccccag cccccagccc     2040

cttctaggcc tgctcttggg aaacagggca tctgtcgctc aacaggccag accaatgtgc     2100

ctgggcaaga tggtgtccta caggtcagat atgaaacagg tgggctggca cctgggcaca     2160

gtgcttgccc ctgctgcctc ttccctccca ggtatgggaa aagacacaaa gaggacacgc     2220

tggccttctc ggagtggggg tccccgcatg ctgctgtccc caggtgagtt tgactccctg     2280

ccctgtctgt ccaggctccc tggggctgaa atgggggtgg tgggactgaa tcagggcttg     2340

gaaaggtgta gtggggggtg gaagagggag aacaggagcc cagggccagc gtgaggcctc     2400

ctgagggcac gaggcctacc ccctacactg ccatgttctg ccctgtcctc acagggagct     2460

cagcccgctg gacttataat gccaccttct gtctcctacg actccatgag cagcgccagc     2520


<210>  5
<211>  1243
<212>  DNA
<213>  Homo sapiens

<400>  5
gggatcatct cgtccatgct aggaaattag ctggtccttc ctcagtaagg aactatttag       60

ataaaagcag tcagaactct ggcctgaaca gtaaacattt aaccagagtt caatcagaat      120

tcaaggacag gttttcttaa actttctttg tttctaggag atcaggcaga gctgaattta      180

accaagaatc ttttgatcct ttccacatat agatatacaa tagtggtcac atatgttctg      240

ggagttccta gaccttatat gtctaaactg gggcttcctg acataaaact atgcttaccg      300

gccaggaatc tgttagaaaa ctcagagctc agtagaagga acactggctt tggaatgtgg      360

aggtctggtt ttgctcaaag tgtgcagtat gtgaaggaga acaatttact gaccattact      420

ctgccttact gattcaaatt ctgaggttta ttgaataatt tcttagattg ccttccagct      480

ctaaatttct cagcaccaaa atgaagtcca tttcaatctc tctctctctc tttccctccc      540

gtacatatac acacactcat acatatatat ggtcacaata gaaaggcagg tagatcagaa      600

gtctcagttg ctgagaaaga gggagggagg gtgagccaga ggtaccttct cccccattgt      660

agagaaaagt gaagttcttt tagagccccg ttacatcttc aaggcttttt atgagataat      720

ggaggaaata aagagggctc agtccttcta ctgtccatat ttcattctca aatctgttat      780

tagaggaatg attctgatct ccacctacca tacacatgcc ctgttgcttg ttgggccttc      840

ctaaaatgtt agagtatgat gacagatgga gttgtctggg tacatttgtg tgcatttaag      900

ggtgatagtg tatttgctct ttaagagctg agtgtttgag cctctgtttg tgtgtaattg      960

agtgtgcatg tgtgggagtg aaattgtgga atgtgtatgc tcatagcact gagtgaaaat     1020

aaaagattgt ataaatcgtg gggcatgtgg aattgtgtgt gcctgtgcgt gtgcagtatt     1080

tttttttttt taagtaagcc actttagatc ttgtcacctc ccctgtcttc tgtgattgat     1140

tttgcgaggc taatggtgcg taaaagggct ggtgagatct gggggcgcct cctagcctga     1200

cgtcagagag agagtttaaa acagagggag acggttgaga gca                       1243


<210>  6
<211>  1723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Promoter

<400>  6
gtcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggact atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atgggtcgag gtgagcccca cgttctgctt cactctcccc      420

atctcccccc cctccccacc cccaattttg tatttattta ttttttaatt attttgtgca      480

gcgatggggg cggggggggg gggggcgcgc gccaggcggg gcggggcggg gcgaggggcg      540

gggcggggcg aggcggagag gtgcggcggc agccaatcag agcggcgcgc tccgaaagtt      600

tccttttatg gcgaggcggc ggcggcggcg gccctataaa aagcgaagcg cgcggcgggc      660

gggagtcgct gcgttgcctt cgccccgtgc cccgctccgc gccgcctcgc gccgcccgcc      720

ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc      780

gggctgtaat tagcgcttgg tttaatgacg gctcgtttct tttctgtggc tgcgtgaaag      840

ccttaaaggg ctccgggagg gccctttgtg cgggggggag cggctcgggg ggtgcgtgcg      900

tgtgtgtgtg cgtggggagc gccgcgtgcg gcccgcgctg cccggcggct gtgagcgctg      960

cgggcgcggc gcggggcttt gtgcgctccg cgtgtgcgcg aggggagcgc ggccgggggc     1020

ggtgccccgc ggtgcggggg ggctgcgagg ggaacaaagg ctgcgtgcgg ggtgtgtgcg     1080

tgggggggtg agcagggggt gtgggcgcgg cggtcgggct gtaacccccc cctgcacccc     1140

cctccccgag ttgctgagca cggcccggct tcgggtgcgg ggctccgtgc ggggcgtggc     1200

gcggggctcg ccgtgccggg cggggggtgg cggcaggtgg gggtgccggg cggggcgggg     1260

ccgcctcggg ccggggaggg ctcgggggag gggcgcggcg gccccggagc gccggcggct     1320

gtcgaggcgc ggcgagccgc agccattgcc ttttatggta atcgtgcgag agggcgcagg     1380

gacttccttt gtcccaaatc tggcggagcc gaaatctggg aggcgccgcc gcaccccctc     1440

tagcgggcgc gggcgaagcg gtgcggcgcc ggcaggaagg aaatgggcgg ggagggcctt     1500

cgtgcgtcgc cgcgccgccg tccccttctc catctccagc ctcggggctg ccgcaggggg     1560

acggctgcct tcggggggga cggggcaggg cggggttcgg cttctggcgt gtgaccggcg     1620

gctctagagc ctctgctaac catgttcatg ccttcttctt tttcctacag ctcctgggca     1680

acgtgctggt tattgtgctg tctcatcatt ttggcaaaga att                       1723


<210>  7
<211>  1178
<212>  DNA
<213>  Homo sapiens

<400>  7
ggctccggtg cccgtcagtg ggcagagcgc acatcgccca cagtccccga gaagttgggg       60

ggaggggtcg gcaattgaac cggtgcctag agaaggtggc gcggggtaaa ctgggaaagt      120

gatgtcgtgt actggctccg cctttttccc gagggtgggg gagaaccgta tataagtgca      180

gtagtcgccg tgaacgttct ttttcgcaac gggtttgccg ccagaacaca ggtaagtgcc      240

gtgtgtggtt cccgcgggcc tggcctcttt acgggttatg gcccttgcgt gccttgaatt      300

acttccactg gctgcagtac gtgattcttg atcccgagct tcgggttgga agtgggtggg      360

agagttcgag gccttgcgct taaggagccc cttcgcctcg tgcttgagtt gaggcctggc      420

ctgggcgctg gggccgccgc gtgcgaatct ggtggcacct tcgcgcctgt ctcgctgctt      480

tcgataagtc tctagccatt taaaattttt gatgacctgc tgcgacgctt tttttctggc      540

aagatagtct tgtaaatgcg ggccaagatc tgcacactgg tatttcggtt tttggggccg      600

cgggcggcga cggggcccgt gcgtcccagc gcacatgttc ggcgaggcgg ggcctgcgag      660

cgcggccacc gagaatcgga cgggggtagt ctcaagctgg ccggcctgct ctggtgcctg      720

gcctcgcgcc gccgtgtatc gccccgccct gggcggcaag gctggcccgg tcggcaccag      780

ttgcgtgagc ggaaagatgg ccgcttcccg gccctgctgc agggagctca aaatggagga      840

cgcggcgctc gggagagcgg gcgggtgagt cacccacaca aaggaaaagg gcctttccgt      900

cctcagccgt cgcttcatgt gactccacgg agtaccgggc gccgtccagg cacctcgatt      960

agttctcgag cttttggagt acgtcgtctt taggttgggg ggaggggttt tatgcgatgg     1020

agtttcccca cactgagtgg gtggagactg aagttaggcc agcttggcac ttgatgtaat     1080

tctccttgga atttgccctt tttgagtttg gatcttggtt cattctcaag cctcagacag     1140

tggttcaaag tttttttctt ccatttcagg tgtcgtga                             1178


<210>  8
<211>  1609
<212>  DNA
<213>  Homo sapiens

<400>  8
gatctctatt tatttagcaa taatagagaa agcatttaag agaataaagc aatggaaata       60

agaaatttgt aaatttcctt ctgataacta gaaatagagg atccagtttc ttttggttaa      120

cctaaatttt atttcatttt attgttttat tttattttat tttattttat tttgtgtaat      180

cgtagtttca gagtgttaga gctgaaagga agaagtagga gaaacatgca aagtaaaagt      240

ataacacttt ccttactaaa ccgacatggg tttccaggta ggggcaggat tcaggatgac      300

tgacagggcc cttagggaac actgagaccc tacgctgacc tcataaatgc ttgctacctt      360

tgctgtttta attacatctt ttaatagcag gaagcagaac tctgcacttc aaaagttttt      420

cctcacctga ggagttaatt tagtacaagg ggaaaaagta cagggggatg ggagaaaggc      480

gatcacgttg ggaagctata gagaaagaag agtaaatttt agtaaaggag gtttaaacaa      540

acaaaatata aagagaaata ggaacttgaa tcaaggaaat gattttaaaa cgcagtattc      600

ttagtggact agaggaaaaa aataatctga gccaagtaga agaccttttc ccctcctacc      660

cctactttct aagtcacaga ggctttttgt tcccccagac actcttgcag attagtccag      720

gcagaaacag ttagatgtcc ccagttaacc tcctatttga caccactgat taccccattg      780

atagtcacac tttgggttgt aagtgacttt ttatttattt gtatttttga ctgcattaag      840

aggtctctag ttttttatct cttgtttccc aaaacctaat aagtaactaa tgcacagagc      900

acattgattt gtatttattc tatttttaga cataatttat tagcatgcat gagcaaatta      960

agaaaaacaa caacaaatga atgcatatat atgtatatgt atgtgtgtat atatacacac     1020

atatatatat atattttttc ttttcttacc agaaggtttt aatccaaata aggagaagat     1080

atgcttagaa ccgaggtaga gttttcatcc attctgtcct gtaagtattt tgcatattct     1140

ggagacgcag gaagagatcc atctacatat cccaaagctg aattatggta gacaaaactc     1200

ttccactttt agtgcatcaa cttcttattt gtgtaataag aaaattggga aaacgatctt     1260

caatatgctt accaagctgt gattccaaat attacgtaaa tacacttgca aaggaggatg     1320

tttttagtag caatttgtac tgatggtatg gggccaagag atatatctta gagggagggc     1380

tgagggtttg aagtccaact cctaagccag tgccagaaga gccaaggaca ggtacggctg     1440

tcatcactta gacctcaccc tgtggagcca caccctaggg ttggccaatc tactcccagg     1500

agcagggagg gcaggagcca gggctgggca taaaagtcag ggcagagcca tctattgctt     1560

acatttgctt ctgacacaac tgtgttcact agcaacctca aacagacac                 1609


<210>  9
<211>  684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  cytomegalovirus promoter

<400>  9
tcaatattgg ccattagcca tattattcat tggttatata gcataaatca atattggcta       60

ttggccattg catacgttgt atctatatca taatatgtac atttatattg gctcatgtcc      120

aatatgaccg ccatgttggc attgattatt gactagttat taatagtaat caattacggg      180

gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg taaatggccc      240

gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt atgttcccat      300

agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac ggtaaactgc      360

ccacttggca gtacatcaag tgtatcatat gccaagtccg ccccctattg acgtcaatga      420

cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact ttcctacttg      480

gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt ggcagtacac      540

caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc ccattgacgt      600

caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc gtaataaccc      660

cgccccgttg acgcaaatgg gcgg                                             684


<210>  10
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Ala Glu Leu Ala Met Gly Ala Glu Leu Pro Ser Ser Pro Leu 
1               5                   10                  15      


Ala Ile Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val Lys 
            20                  25                  30          


Lys Glu Pro Pro Glu Ala Glu Arg Phe Cys His Arg Leu Pro Pro Gly 
        35                  40                  45              


Ser Leu Ser Ser Thr Pro Leu Ser Thr Pro Cys Ser Ser Val Pro Ser 
    50                  55                  60                  


Ser Pro Ser Phe Cys Ala Pro Ser Pro Gly Thr Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Ala Gly Gly Gly Gly Gly Ser Ser Gln Ala Gly Gly Ala Pro Gly Pro 
                85                  90                  95      


Pro Ser Gly Gly Pro Gly Ala Val Gly Gly Thr Ser Gly Lys Pro Ala 
            100                 105                 110         


Leu Glu Asp Leu Tyr Trp Met Ser Gly Tyr Gln His His Leu Asn Pro 
        115                 120                 125             


Glu Ala Leu Asn Leu Thr Pro Glu Asp Ala Val Glu Ala Leu Ile Gly 
    130                 135                 140                 


Ser Gly His His Gly Ala His His Gly Ala His His Pro Ala Ala Ala 
145                 150                 155                 160 


Ala Ala Tyr Glu Ala Phe Arg Gly Pro Gly Phe Ala Gly Gly Gly Gly 
                165                 170                 175     


Ala Asp Asp Met Gly Ala Gly His His His Gly Ala His His Ala Ala 
            180                 185                 190         


His His His His Ala Ala His His His His His His His His His His 
        195                 200                 205             


Gly Gly Ala Gly His Gly Gly Gly Ala Gly His His Val Arg Leu Glu 
    210                 215                 220                 


Glu Arg Phe Ser Asp Asp Gln Leu Val Ser Met Ser Val Arg Glu Leu 
225                 230                 235                 240 


Asn Arg Gln Leu Arg Gly Phe Ser Lys Glu Glu Val Ile Arg Leu Lys 
                245                 250                 255     


Gln Lys Arg Arg Thr Leu Lys Asn Arg Gly Tyr Ala Gln Ser Cys Arg 
            260                 265                 270         


Phe Lys Arg Val Gln Gln Arg His Ile Leu Glu Ser Glu Lys Cys Gln 
        275                 280                 285             


Leu Gln Ser Gln Val Glu Gln Leu Lys Leu Glu Val Gly Arg Leu Ala 
    290                 295                 300                 


Lys Glu Arg Asp Leu Tyr Lys Glu Lys Tyr Glu Lys Leu Ala Gly Arg 
305                 310                 315                 320 


Gly Gly Pro Gly Ser Ala Gly Gly Ala Gly Phe Pro Arg Glu Pro Ser 
                325                 330                 335     


Pro Pro Gln Ala Gly Pro Gly Gly Ala Lys Gly Thr Ala Asp Phe Phe 
            340                 345                 350         


Leu 
    


<210>  11
<211>  359
<212>  PRT
<213>  Mus musculus

<400>  11

Met Ala Ala Glu Leu Ala Met Gly Ala Glu Leu Pro Ser Ser Pro Leu 
1               5                   10                  15      


Ala Ile Glu Tyr Val Asn Asp Phe Asp Leu Met Lys Phe Glu Val Lys 
            20                  25                  30          


Lys Glu Pro Pro Glu Ala Glu Arg Phe Cys His Arg Leu Pro Pro Gly 
        35                  40                  45              


Ser Leu Ser Ser Thr Pro Leu Ser Thr Pro Cys Ser Ser Val Pro Ser 
    50                  55                  60                  


Ser Pro Ser Phe Cys Ala Pro Ser Pro Gly Thr Gly Gly Gly Ala Gly 
65                  70                  75                  80  


Gly Gly Gly Ser Ala Ala Gln Ala Gly Gly Ala Pro Gly Pro Pro Ser 
                85                  90                  95      


Gly Gly Pro Gly Thr Val Gly Gly Ala Ser Gly Lys Ala Val Leu Glu 
            100                 105                 110         


Asp Leu Tyr Trp Met Ser Gly Tyr Gln His His Leu Asn Pro Glu Ala 
        115                 120                 125             


Leu Asn Leu Thr Pro Glu Asp Ala Val Glu Ala Leu Ile Gly Ser Gly 
    130                 135                 140                 


His His Gly Ala His His Gly Ala His His Pro Ala Ala Ala Ala Ala 
145                 150                 155                 160 


Tyr Glu Ala Phe Arg Gly Gln Ser Phe Ala Gly Gly Gly Gly Ala Asp 
                165                 170                 175     


Asp Met Gly Ala Gly His His His Gly Ala His His Thr Ala His His 
            180                 185                 190         


His His Ser Ala His His His His His His His His His His Gly Gly 
        195                 200                 205             


Ser Gly His His Gly Gly Gly Ala Gly His Gly Gly Gly Gly Ala Gly 
    210                 215                 220                 


His His Val Arg Leu Glu Glu Arg Phe Ser Asp Asp Gln Leu Val Ser 
225                 230                 235                 240 


Met Ser Val Arg Glu Leu Asn Arg Gln Leu Arg Gly Phe Ser Lys Glu 
                245                 250                 255     


Glu Val Ile Arg Leu Lys Gln Lys Arg Arg Thr Leu Lys Asn Arg Gly 
            260                 265                 270         


Tyr Ala Gln Ser Cys Arg Phe Lys Arg Val Gln Gln Arg His Ile Leu 
        275                 280                 285             


Glu Ser Glu Lys Cys Gln Leu Gln Ser Gln Val Glu Gln Leu Lys Leu 
    290                 295                 300                 


Glu Val Gly Arg Leu Ala Lys Glu Arg Asp Leu Tyr Lys Glu Lys Tyr 
305                 310                 315                 320 


Glu Lys Leu Ala Gly Arg Gly Gly Pro Gly Gly Ala Gly Gly Ala Gly 
                325                 330                 335     


Phe Pro Arg Glu Pro Ser Pro Ala Gln Ala Gly Pro Gly Ala Ala Lys 
            340                 345                 350         


Gly Ala Pro Asp Phe Phe Leu 
        355                 


<210>  12
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asn Gly Glu Glu Gln Tyr Tyr Ala Ala Thr Gln Leu Tyr Lys Asp 
1               5                   10                  15      


Pro Cys Ala Phe Gln Arg Gly Pro Ala Pro Glu Phe Ser Ala Ser Pro 
            20                  25                  30          


Pro Ala Cys Leu Tyr Met Gly Arg Gln Pro Pro Pro Pro Pro Pro His 
        35                  40                  45              


Pro Phe Pro Gly Ala Leu Gly Ala Leu Glu Gln Gly Ser Pro Pro Asp 
    50                  55                  60                  


Ile Ser Pro Tyr Glu Val Pro Pro Leu Ala Asp Asp Pro Ala Val Ala 
65                  70                  75                  80  


His Leu His His His Leu Pro Ala Gln Leu Ala Leu Pro His Pro Pro 
                85                  90                  95      


Ala Gly Pro Phe Pro Glu Gly Ala Glu Pro Gly Val Leu Glu Glu Pro 
            100                 105                 110         


Asn Arg Val Gln Leu Pro Phe Pro Trp Met Lys Ser Thr Lys Ala His 
        115                 120                 125             


Ala Trp Lys Gly Gln Trp Ala Gly Gly Ala Tyr Ala Ala Glu Pro Glu 
    130                 135                 140                 


Glu Asn Lys Arg Thr Arg Thr Ala Tyr Thr Arg Ala Gln Leu Leu Glu 
145                 150                 155                 160 


Leu Glu Lys Glu Phe Leu Phe Asn Lys Tyr Ile Ser Arg Pro Arg Arg 
                165                 170                 175     


Val Glu Leu Ala Val Met Leu Asn Leu Thr Glu Arg His Ile Lys Ile 
            180                 185                 190         


Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Glu Asp Lys Lys 
        195                 200                 205             


Arg Gly Gly Gly Thr Ala Val Gly Gly Gly Gly Val Ala Glu Pro Glu 
    210                 215                 220                 


Gln Asp Cys Ala Val Thr Ser Gly Glu Glu Leu Leu Ala Leu Pro Pro 
225                 230                 235                 240 


Pro Pro Pro Pro Gly Gly Ala Val Pro Pro Ala Ala Pro Val Ala Ala 
                245                 250                 255     


Arg Glu Gly Arg Leu Pro Pro Gly Leu Ser Ala Ser Pro Gln Pro Ser 
            260                 265                 270         


Ser Val Ala Pro Arg Arg Pro Gln Glu Pro Arg 
        275                 280             


<210>  13
<211>  284
<212>  PRT
<213>  Mus musculus

<400>  13

Met Asn Ser Glu Glu Gln Tyr Tyr Ala Ala Thr Gln Leu Tyr Lys Asp 
1               5                   10                  15      


Pro Cys Ala Phe Gln Arg Gly Pro Val Pro Glu Phe Ser Ala Asn Pro 
            20                  25                  30          


Pro Ala Cys Leu Tyr Met Gly Arg Gln Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


Gln Phe Thr Ser Ser Leu Gly Ser Leu Glu Gln Gly Ser Pro Pro Asp 
    50                  55                  60                  


Ile Ser Pro Tyr Glu Val Pro Pro Leu Ala Ser Asp Asp Pro Ala Gly 
65                  70                  75                  80  


Ala His Leu His His His Leu Pro Ala Gln Leu Gly Leu Ala His Pro 
                85                  90                  95      


Pro Pro Gly Pro Phe Pro Asn Gly Thr Glu Pro Gly Gly Leu Glu Glu 
            100                 105                 110         


Pro Asn Arg Val Gln Leu Pro Phe Pro Trp Met Lys Ser Thr Lys Ala 
        115                 120                 125             


His Ala Trp Lys Gly Gln Trp Ala Gly Gly Ala Tyr Thr Ala Glu Pro 
    130                 135                 140                 


Glu Glu Asn Lys Arg Thr Arg Thr Ala Tyr Thr Arg Ala Gln Leu Leu 
145                 150                 155                 160 


Glu Leu Glu Lys Glu Phe Leu Phe Asn Lys Tyr Ile Ser Arg Pro Arg 
                165                 170                 175     


Arg Val Glu Leu Ala Val Met Leu Asn Leu Thr Glu Arg His Ile Lys 
            180                 185                 190         


Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys Glu Glu Asp Lys 
        195                 200                 205             


Lys Arg Ser Ser Gly Thr Pro Ser Gly Gly Gly Gly Gly Glu Glu Pro 
    210                 215                 220                 


Glu Gln Asp Cys Ala Val Thr Ser Gly Glu Glu Leu Leu Ala Val Pro 
225                 230                 235                 240 


Pro Leu Pro Pro Pro Gly Gly Ala Val Pro Pro Gly Val Pro Ala Ala 
                245                 250                 255     


Val Arg Glu Gly Leu Leu Pro Ser Gly Leu Ser Val Ser Pro Gln Pro 
            260                 265                 270         


Ser Ser Ile Ala Pro Leu Arg Pro Gln Glu Pro Arg 
        275                 280                 


<210>  14
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  connector

<400>  14
cgcgccaagc gcggctccgg cgccaccaac ttctccctgc tgaagcag                    48


<210>  15
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Connector

<400>  15
cgcgccaagc gcggctccgg ccagtgcacc aactacgccc tgctgaagct ggccggcgac       60

gtggagtcca accccggccc c                                                 81


<210>  16
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Connector

<400>  16
cgcgccaagc gcggctccgg cgagggcaga ggaagtcttc taacatgcgg tgacgtggag       60

gagaatcccg gccct                                                        75


<210>  17
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Pro His Pro Leu Asp Ala Leu Thr Ile Gln Val Ser Pro Glu 
1               5                   10                  15      


Thr Gln Gln Pro Phe Pro Gly Ala Ser Asp His Glu Val Leu Ser Ser 
            20                  25                  30          


Asn Ser Thr Pro Pro Ser Pro Thr Leu Ile Pro Arg Asp Cys Ser Glu 
        35                  40                  45              


Ala Glu Val Gly Asp Cys Arg Gly Thr Ser Arg Lys Leu Arg Ala Arg 
    50                  55                  60                  


Arg Gly Gly Arg Asn Arg Pro Lys Ser Glu Leu Ala Leu Ser Lys Gln 
65                  70                  75                  80  


Arg Arg Ser Arg Arg Lys Lys Ala Asn Asp Arg Glu Arg Asn Arg Met 
                85                  90                  95      


His Asn Leu Asn Ser Ala Leu Asp Ala Leu Arg Gly Val Leu Pro Thr 
            100                 105                 110         


Phe Pro Asp Asp Ala Lys Leu Thr Lys Ile Glu Thr Leu Arg Phe Ala 
        115                 120                 125             


His Asn Tyr Ile Trp Ala Leu Thr Gln Thr Leu Arg Ile Ala Asp His 
    130                 135                 140                 


Ser Phe Tyr Gly Pro Glu Pro Pro Val Pro Cys Gly Glu Leu Gly Ser 
145                 150                 155                 160 


Pro Gly Gly Gly Ser Asn Gly Asp Trp Gly Ser Ile Tyr Ser Pro Val 
                165                 170                 175     


Ser Gln Ala Gly Asn Leu Ser Pro Thr Ala Ser Leu Glu Glu Phe Pro 
            180                 185                 190         


Gly Leu Gln Val Pro Ser Ser Pro Ser Tyr Leu Leu Pro Gly Ala Leu 
        195                 200                 205             


Val Phe Ser Asp Phe Leu 
    210                 


