                         SEQUENCE LISTING

<110>  EMORY UNIVERSITY
       CHILDREN'S HEALTHCARE OF ATLANTA, INC.
       Galipeau, Jacques
       Pennati, Andrea
 
<120>  COMPOSITIONS OF GM-CSF AND INTERLEUKIN FUSIONS FOR IMMUNE 
       MODULATION AND USES RELATED THERETO

<130>  13157 PCT

<150>  US 61/982,912
<151>  2014-04-23

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  116
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Where X is Alanine or Glycine

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  Where X is Methionine or Lysine

<220>
<221>  MISC_FEATURE
<222>  (100)..(100)
<223>  Where X is Isolecine or Threonine

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Where X is Phenylalanine or Leucine

<400>  1

Ala Pro Xaa Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Xaa Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Xaa Ile Thr Phe Glu Ser Xaa Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val 
        115     


<210>  2
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val 
        115     


<210>  3
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Thr Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val 
        115     


<210>  4
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Pro Gly Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Thr Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val 
        115     


<210>  5
<211>  114
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Where X is Glutamate or Lysine

<400>  5

Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Xaa Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser 
        


<210>  6
<211>  128
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  where X is Leucine or Isoleucine or Valine

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  where X is Phenylalanie or Aspartate

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  where X is Leucine or Isoleucine or Valine

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  where X is Leucine or Cysteine

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  where X is Glycine or serine

<220>
<221>  MISC_FEATURE
<222>  (109)..(109)
<223>  where X is Glutamate or Lysine

<400>  6

Xaa Xaa Xaa Xaa Xaa Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala 
1               5                   10                  15      


Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
            20                  25                  30          


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
        35                  40                  45              


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
    50                  55                  60                  


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
65                  70                  75                  80  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
                85                  90                  95      


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Xaa Lys Asn Ile 
            100                 105                 110         


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
        115                 120                 125             


<210>  7
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  7

Val Phe Ile Leu Gly 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  8

Ile Asp Leu Cys Ser 
1               5   


<210>  9
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  9

Val Leu Gly Thr Ile Asp Leu Cys Ser Cys Phe Ser Ala Gly Leu Pro 
1               5                   10                  15      


Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
            20                  25                  30          


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
        35                  40                  45              


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
    50                  55                  60                  


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
65                  70                  75                  80  


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
                85                  90                  95      


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            100                 105                 110         


Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
        115                 120                 125             


Met Phe Ile Asn Thr Ser 
    130                 


<210>  10
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  10

Val Leu Gly Thr Ile Asp Leu Cys Ser Cys Phe Ser Ala Gly Leu Pro 
1               5                   10                  15      


Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile 
            20                  25                  30          


Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu 
        35                  40                  45              


Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu 
    50                  55                  60                  


Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His 
65                  70                  75                  80  


Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser 
                85                  90                  95      


Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu 
            100                 105                 110         


Lys Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln 
        115                 120                 125             


Met Phe Ile Asn Thr Ser 
    130                 


<210>  11
<211>  161
<212>  PRT
<213>  Homo sapiens

<400>  11

Arg Ile Ser Lys Pro His Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu 
1               5                   10                  15      


Cys Leu Leu Leu Asn Ser His Phe Leu Thr Glu Ala Gly Ile His Val 
            20                  25                  30          


Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn 
        35                  40                  45              


Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln 
    50                  55                  60                  


Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro 
65                  70                  75                  80  


Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val 
                85                  90                  95      


Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn 
            100                 105                 110         


Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr 
        115                 120                 125             


Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys 
    130                 135                 140                 


Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr 
145                 150                 155                 160 


Ser 
    


<210>  12
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  12

Gly His Met Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp 
1               5                   10                  15      


Glu His Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser 
            20                  25                  30          


Arg Asp Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu 
        35                  40                  45              


Met Phe Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu 
    50                  55                  60                  


Tyr Lys Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu 
65                  70                  75                  80  


Thr Met Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu 
                85                  90                  95      


Thr Ser Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn 
            100                 105                 110         


Leu Lys Asp Phe Leu Leu Val Gly Ser Met Arg Ile Ser Lys Pro His 
        115                 120                 125             


Leu Arg Ser Ile Ser Ile Gln Cys Tyr Leu Cys Leu Leu Leu Asn Ser 
    130                 135                 140                 


His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile Leu Gly Cys Phe 
145                 150                 155                 160 


Ser Ala Gly Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser 
                165                 170                 175     


Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala 
            180                 185                 190         


Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala 
        195                 200                 205             


Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly 
    210                 215                 220                 


Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn 
225                 230                 235                 240 


Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu 
                245                 250                 255     


Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe 
            260                 265                 270         


Val His Ile Val Gln Met Phe Ile Asn Thr Ser 
        275                 280             


<210>  13
<211>  8
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Where X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Where X is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Where X is Glycine or Serine

<400>  13

Glu Xaa Xaa Tyr Xaa Gln Xaa His 
1               5               


<210>  14
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Asn Leu Tyr Phe Gln Gly His 
1               5               


<210>  15
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser 
    130 


<210>  16
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  16

Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala Cys 
1               5                   10                  15      


Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln Glu 
            20                  25                  30          


Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr 
        35                  40                  45              


Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu 
    50                  55                  60                  


Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser 
65                  70                  75                  80  


His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe 
                85                  90                  95      


His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn 
            100                 105                 110         


Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn 
        115                 120                 125             


Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg 
    130                 135                 140                 


Glu Lys Tyr Ser Lys Cys Ser Ser 
145                 150         


<210>  17
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  17

Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val Ala Gly Gln Gly Cys 
1               5                   10                  15      


Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe Leu Ile Asn Lys Met 
            20                  25                  30          


Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser Ala Asn Val Thr Ser 
        35                  40                  45              


Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys Thr Arg Pro Cys Phe 
    50                  55                  60                  


Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr Met Gln Thr Arg Tyr 
65                  70                  75                  80  


Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val Glu Val Leu Lys Asn 
                85                  90                  95      


Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro Cys Asn Gln Thr Thr 
            100                 105                 110         


Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu Leu Glu Ile Phe Gln 
        115                 120                 125             


Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 


<210>  18
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Leu Glu Lys Arg 
1               5   


<210>  19
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Gly Ser Met Arg Ile Ser Lys Pro His Leu Arg Ser 
        115                 120                 125             


Ile Ser Ile Gln Cys Tyr Leu Cys Leu Leu Leu Asn Ser His Phe Leu 
    130                 135                 140                 


Thr Glu Ala Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly 
145                 150                 155                 160 


Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
                165                 170                 175     


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
            180                 185                 190         


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
        195                 200                 205             


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
    210                 215                 220                 


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
225                 230                 235                 240 


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
                245                 250                 255     


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
            260                 265                 270         


Val Gln Met Phe Ile Asn Thr Ser Leu Glu Gln Lys Leu Ile Ser Glu 
        275                 280                 285             


Glu Asp Leu Asn Ser Ala Val Asp His His His His His His 
    290                 295                 300         


<210>  20
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  20

Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His Val 
1               5                   10                  15      


Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val Thr 
            20                  25                  30          


Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys Lys 
        35                  40                  45              


Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu Arg 
    50                  55                  60                  


Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser Tyr 
65                  70                  75                  80  


Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr Gln 
                85                  90                  95      


Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu Thr 
            100                 105                 110         


Asp Asp Pro Gly Arg Arg Ala Ile Met Lys Ile Leu Lys Pro Tyr Met 
        115                 120                 125             


Arg Asn Thr Ser Ile Ser Cys Tyr Leu Cys Phe Leu Leu Asn Ser His 
    130                 135                 140                 


Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile Leu Gly Cys Val Ser 
145                 150                 155                 160 


Val Gly Leu Pro Lys Thr Glu Ala Asn Trp Ile Asp Val Arg Tyr Asp 
                165                 170                 175     


Leu Glu Lys Ile Glu Ser Leu Ile Gln Ser Ile His Ile Asp Thr Thr 
            180                 185                 190         


Leu Tyr Thr Asp Ser Asp Phe His Pro Ser Cys Lys Val Thr Ala Met 
        195                 200                 205             


Asn Cys Phe Leu Leu Glu Leu Gln Val Ile Leu His Glu Tyr Ser Asn 
    210                 215                 220                 


Met Thr Leu Asn Glu Thr Val Arg Asn Val Leu Tyr Leu Ala Asn Ser 
225                 230                 235                 240 


Thr Leu Ser Ser Asn Lys Asn Val Ala Glu Ser Gly Cys Lys Glu Cys 
                245                 250                 255     


Glu Glu Leu Glu Glu Lys Thr Phe Thr Glu Phe Leu Gln Ser Phe Ile 
            260                 265                 270         


Arg Ile Val Gln Met Phe Ile Asn Thr Ser 
        275                 280         


<210>  21
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  21

Gly His Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys 
1               5                   10                  15      


His Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro 
            20                  25                  30          


Val Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe 
        35                  40                  45              


Lys Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly 
    50                  55                  60                  


Leu Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala 
65                  70                  75                  80  


Ser Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu 
                85                  90                  95      


Thr Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe 
            100                 105                 110         


Leu Thr Asp Asp Pro Gly Arg Arg Ala Ile Met Lys Ile Leu Lys Pro 
        115                 120                 125             


Tyr Met Arg Asn Thr Ser Ile Ser Cys Tyr Leu Cys Phe Leu Leu Asn 
    130                 135                 140                 


Ser His Phe Leu Thr Glu Ala Gly Ile His Val Phe Ile Leu Gly Cys 
145                 150                 155                 160 


Val Ser Val Gly Leu Pro Lys Thr Glu Ala Asn Trp Ile Asp Val Arg 
                165                 170                 175     


Tyr Asp Leu Glu Lys Ile Glu Ser Leu Ile Gln Ser Ile His Ile Asp 
            180                 185                 190         


Thr Thr Leu Tyr Thr Asp Ser Asp Phe His Pro Ser Cys Lys Val Thr 
        195                 200                 205             


Ala Met Asn Cys Phe Leu Leu Glu Leu Gln Val Ile Leu His Glu Tyr 
    210                 215                 220                 


Ser Asn Met Thr Leu Asn Glu Thr Val Arg Asn Val Leu Tyr Leu Ala 
225                 230                 235                 240 


Asn Ser Thr Leu Ser Ser Asn Lys Asn Val Ala Glu Ser Gly Cys Lys 
                245                 250                 255     


Glu Cys Glu Glu Leu Glu Glu Lys Thr Phe Thr Glu Phe Leu Gln Ser 
            260                 265                 270         


Phe Ile Arg Ile Val Gln Met Phe Ile Asn Thr Ser 
        275                 280                 


<210>  22
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  22

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Gly Ser Met Arg Ile Ser Lys Pro His Leu Arg Ser 
        115                 120                 125             


Ile Ser Ile Gln Cys Tyr Leu Cys Leu Leu Leu Asn Ser His Phe Leu 
    130                 135                 140                 


Thr Glu Ala Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly 
145                 150                 155                 160 


Leu Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys 
                165                 170                 175     


Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr 
            180                 185                 190         


Thr Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys 
        195                 200                 205             


Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser 
    210                 215                 220                 


Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu 
225                 230                 235                 240 


Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu 
                245                 250                 255     


Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile 
            260                 265                 270         


Val Gln Met Phe Ile Asn Thr Ser 
        275                 280 


<210>  23
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Pro Val Asn Thr Thr Thr Glu Asp Glu Thr Ala Gln 
            20                  25                  30          


Ile Pro Ala Glu Ala Val Ile Gly Tyr Ser Asp Leu Glu Gly Asp Phe 
        35                  40                  45              


Asp Val Ala Val Leu Pro Phe Ser Asn Ser Thr Asn Asn Gly Leu Leu 
    50                  55                  60                  


Phe Ile Asn Thr Thr Ile Ala Ser Ile Ala Ala Lys Glu Glu Gly Val 
65                  70                  75                  80  


Ser Leu Glu Lys Arg Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln 
                85                  90                  95      


Pro Trp Glu His Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn 
            100                 105                 110         


Leu Ser Arg Asp Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile 
        115                 120                 125             


Ser Glu Met Phe Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu 
    130                 135                 140                 


Glu Leu Tyr Lys Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly 
145                 150                 155                 160 


Pro Leu Thr Met Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr 
                165                 170                 175     


Pro Glu Thr Ser Cys Ala Thr Gln Thr Ile Thr Phe Glu Ser Phe Lys 
            180                 185                 190         


Glu Asn Leu Lys Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu 
        195                 200                 205             


Pro Val Gln Glu Ser Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu 
    210                 215                 220                 


Phe Phe Leu Leu Ala Cys Ala Gly Asn Phe Val His Gly His Lys Cys 
225                 230                 235                 240 


Asp Ile Thr Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu 
                245                 250                 255     


Gln Lys Thr Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala 
            260                 265                 270         


Ser Lys Asn Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val 
        275                 280                 285             


Leu Arg Gln Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly 
    290                 295                 300                 


Ala Thr Ala Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu 
305                 310                 315                 320 


Lys Arg Leu Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys 
                325                 330                 335     


Pro Val Lys Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg 
            340                 345                 350         


Leu Lys Thr Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
        355                 360                 365     


<210>  24
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  24

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Thr Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu Ser 
        115                 120                 125             


Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
    130                 135                 140                 


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
145                 150                 155                 160 


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
                165                 170                 175     


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
            180                 185                 190         


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
        195                 200                 205             


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
    210                 215                 220                 


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
225                 230                 235                 240 


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
                245                 250                 255     


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
            260                 265                 270         


Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
        275                 280     


<210>  25
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  25

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Thr Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu Ser 
        115                 120                 125             


Met Gly Leu Thr Ser Gln Leu Leu Pro Pro Leu Phe Phe Leu Leu Ala 
    130                 135                 140                 


Cys Ala Gly Asn Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln 
145                 150                 155                 160 


Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys 
                165                 170                 175     


Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr 
            180                 185                 190         


Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr 
        195                 200                 205             


Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln 
    210                 215                 220                 


Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg 
225                 230                 235                 240 


Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala 
                245                 250                 255     


Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met 
            260                 265                 270         


Arg Glu Lys Tyr Ser Lys Cys Ser Ser Leu Glu Gln Lys Leu Ile Ser 
        275                 280                 285             


Glu Glu Asp Leu Asn Ser Ala Val Asp His His His His His His 
    290                 295                 300             


<210>  26
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  26

Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His Val 
1               5                   10                  15      


Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp Thr 
            20                  25                  30          


Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe Asp 
        35                  40                  45              


Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys Gln 
    50                  55                  60                  


Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met Met 
65                  70                  75                  80  


Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser Cys 
                85                  90                  95      


Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys Asp 
            100                 105                 110         


Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
        115                 120                 125         


<210>  27
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  27

Phe Val His Gly His Lys Cys Asp Ile Thr Leu Gln Glu Ile Ile Lys 
1               5                   10                  15      


Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr Leu Cys Thr Glu Leu Thr 
            20                  25                  30          


Val Thr Asp Ile Phe Ala Ala Ser Lys Asn Thr Thr Glu Lys Glu Thr 
        35                  40                  45              


Phe Cys Arg Ala Ala Thr Val Leu Arg Gln Phe Tyr Ser His His Glu 
    50                  55                  60                  


Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala Gln Gln Phe His Arg His 
65                  70                  75                  80  


Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu Asp Arg Asn Leu Trp Gly 
                85                  90                  95      


Leu Ala Gly Leu Asn Ser Cys Pro Val Lys Glu Ala Asn Gln Ser Thr 
            100                 105                 110         


Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr Ile Met Arg Glu Lys Tyr 
        115                 120                 125             


Ser Lys Cys Ser Ser 
    130             


<210>  28
<211>  123
<212>  PRT
<213>  Homo sapiens

<400>  28

Leu Gln Glu Ile Ile Lys Thr Leu Asn Ser Leu Thr Glu Gln Lys Thr 
1               5                   10                  15      


Leu Cys Thr Glu Leu Thr Val Thr Asp Ile Phe Ala Ala Ser Lys Asn 
            20                  25                  30          


Thr Thr Glu Lys Glu Thr Phe Cys Arg Ala Ala Thr Val Leu Arg Gln 
        35                  40                  45              


Phe Tyr Ser His His Glu Lys Asp Thr Arg Cys Leu Gly Ala Thr Ala 
    50                  55                  60                  


Gln Gln Phe His Arg His Lys Gln Leu Ile Arg Phe Leu Lys Arg Leu 
65                  70                  75                  80  


Asp Arg Asn Leu Trp Gly Leu Ala Gly Leu Asn Ser Cys Pro Val Lys 
                85                  90                  95      


Glu Ala Asn Gln Ser Thr Leu Glu Asn Phe Leu Glu Arg Leu Lys Thr 
            100                 105                 110         


Ile Met Arg Glu Lys Tyr Ser Lys Cys Ser Ser 
        115                 120             


<210>  29
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Leu Leu Ala Met Val Leu Thr Ser Ala Leu Leu Leu Cys Ser Val 
1               5                   10                  15      


Ala Gly Gln Gly Cys Pro Thr Leu Ala Gly Ile Leu Asp Ile Asn Phe 
            20                  25                  30          


Leu Ile Asn Lys Met Gln Glu Asp Pro Ala Ser Lys Cys His Cys Ser 
        35                  40                  45              


Ala Asn Val Thr Ser Cys Leu Cys Leu Gly Ile Pro Ser Asp Asn Cys 
    50                  55                  60                  


Thr Arg Pro Cys Phe Ser Glu Arg Leu Ser Gln Met Thr Asn Thr Thr 
65                  70                  75                  80  


Met Gln Thr Arg Tyr Pro Leu Ile Phe Ser Arg Val Lys Lys Ser Val 
                85                  90                  95      


Glu Val Leu Lys Asn Asn Lys Cys Pro Tyr Phe Ser Cys Glu Gln Pro 
            100                 105                 110         


Cys Asn Gln Thr Thr Ala Gly Asn Ala Leu Thr Phe Leu Lys Ser Leu 
        115                 120                 125             


Leu Glu Ile Phe Gln Lys Glu Lys Met Arg Gly Met Arg Gly Lys Ile 
    130                 135                 140                 


