                         SEQUENCE LISTING

<110>  GENETHON et al.
 
<120>  TREATMENT OF HYPERBILIRUBINEMIA

<130>  B1801PC00

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  1602
<212>  DNA
<213>  homo sapiens

<400>  1
atggctgtgg agtcccaggg cggacgccca cttgtcctgg gcctgctgct gtgtgtgctg       60

ggcccagtgg tgtcccatgc tgggaagata ctgttgatcc cagtggatgg cagccactgg      120

ctgagcatgc ttggggccat ccagcagctg cagcagaggg gacatgaaat agttgtccta      180

gcacctgacg cctcgttgta catcagagac ggagcatttt acaccttgaa gacgtaccct      240

gtgccattcc aaagggagga tgtgaaagag tcttttgtta gtctcgggca taatgttttt      300

gagaatgatt ctttcctgca gcgtgtgatc aaaacataca agaaaataaa aaaggactct      360

gctatgcttt tgtctggctg ttcccactta ctgcacaaca aggagctcat ggcctccctg      420

gcagaaagca gctttgatgt catgctgacg gaccctttcc ttccttgcag ccccatcgtg      480

gcccagtacc tgtctctgcc cactgtattc ttcttgcatg cactgccatg cagcctggaa      540

tttgaggcta cccagtgccc caacccattc tcctacgtgc ccaggcctct ctcctctcat      600

tcagatcaca tgaccttcct gcagcgggtg aagaacatgc tcattgcctt ttcacagaac      660

tttctgtgcg acgtggttta ttccccgtat gcaacccttg cctcagaatt ccttcagaga      720

gaggtgactg tccaggacct attgagctct gcatctgtct ggctgtttag aagtgacttt      780

gtgaaggatt accctaggcc catcatgccc aatatggttt ttgttggtgg aatcaactgc      840

cttcaccaaa atccactatc ccaggaattt gaagcctaca ttaatgcttc tggagaacat      900

ggaattgtgg ttttctcttt gggatcaatg gtctcagaaa ttccagagaa gaaagctatg      960

gcaattgctg atgctttggg caaaatccct cagacagtcc tgtggcggta cactggaacc     1020

cgaccatcga atcttgcgaa caacacgata cttgttaagt ggctacccca aaacgatctg     1080

cttggtcacc cgatgacccg tgcctttatc acccatgctg gttcccatgg tgtttatgaa     1140

agcatatgca atggcgttcc catggtgatg atgcccttgt ttggtgatca gatggacaat     1200

gcaaagcgca tggagactaa gggagctgga gtgaccctga atgttctgga aatgacttct     1260

gaagatttag aaaatgctct aaaagcagtc atcaatgaca aaagttacaa ggagaacatc     1320

atgcgcctct ccagccttca caaggaccgc ccggtggagc cgctggacct ggccgtgttc     1380

tgggtggagt ttgtgatgag gcacaagggc gcgccacacc tgcgccccgc agcccacgac     1440

ctcacctggt accagtacca ttccttggac gtgattggtt tcctcttggc cgtcgtgctg     1500

acagtggcct tcatcacctt taaatgttgt gcttatggct accggaaatg cttggggaaa     1560

aaagggcgag ttaagaaagc ccacaaatcc aagacccatt ga                        1602


<210>  2
<211>  1602
<212>  DNA
<213>  artificial

<220>
<223>  optimized UGT1A1 v2.1

<400>  2
atggctgtgg aatcacaagg aggtagacca ctggttctcg gacttttgct ttgcgtgctg       60

gggcccgtgg tgtcgcatgc cggaaagatc ctgctgatcc cggtggatgg atcacactgg      120

ctgtccatgc tgggtgccat ccaacagctc cagcagcggg gccacgaaat tgtggtcctg      180

gccccggacg cttccctgta tattcgggac ggagcgttct acactctcaa gacctaccct      240

gtccccttcc aaagggagga cgtgaaggaa agctttgtgt cgctggggca taatgtgttc      300

gagaacgaca gcttcctcca aagggttatt aaaacctaca agaagatcaa aaaggattcg      360

gccatgctcc tttccggatg ttcacacctg ttgcataaca aggaattgat ggccagcctg      420

gcagaatcca gctttgacgt catgcttact gacccgttct tgccttgctc cccgattgtg      480

gcccaatacc tgtcgctccc aaccgtgttc ttcctgcacg ccttgccttg ttcgctggaa      540

ttcgaagcga ctcagtgtcc caatccgttc tcctacgtcc cgcgcccgct ttcaagccat      600

tcggatcaca tgactttcct ccagcgcgtc aagaacatgc tcattgcgtt cagccagaac      660

tttctgtgcg acgtggttta ctcaccttac gctaccttgg cttctgagtt cctgcagaga      720

gaagtgactg tgcaagatct gctgtcctca gcgtccgttt ggttgttccg gtctgacttc      780

gtcaaggact acccgcgccc gatcatgccg aatatggtct ttgtgggcgg tatcaactgc      840

ctgcatcaaa acccactgag ccaggagttt gaggcgtaca tcaacgcctc gggagagcat      900

ggaatcgtgg tgttctccct cggttccatg gtgtccgaga tcccggaaaa gaaggcaatg      960

gccatcgcag atgccctggg caaaatcccg cagaccgtgc tctggcgcta cacgggtact     1020

cggcctagca atttggcaaa caacaccatc ctggtgaaat ggctgccgca gaacgacctc     1080

ctgggccacc caatgactcg cgctttcatt acccatgcgg gctcgcacgg agtctacgaa     1140

tccatctgca atggagtccc gatggtgatg atgccacttt tcggagatca gatggataat     1200

gcaaaaagaa tggaaaccaa gggggccgga gtgacgctga acgtgcttga aatgacctcg     1260

gaagatctgg agaacgctct caaagcggtg atcaacgaca agtcctacaa ggaaaacatc     1320

atgcgcctga gctccctcca caaggaccga ccagtggaac cgctggacct cgcggtcttt     1380

tgggtggagt tcgtgatgag gcacaagggc gccccccacc tcagacccgc agctcatgac     1440

ctcacttggt accagtacca ttcgctggat gtcatcggct ttctcctggc ggtcgtgctc     1500

accgtggcgt tcatcacctt caagtgctgc gcctacggat atcgcaaatg cttggggaag     1560

aaaggacggg tgaagaaggc acacaagtca aagacgcact ga                        1602


<210>  3
<211>  1602
<212>  DNA
<213>  artificial

<220>
<223>  optimized UGT1A1 v3

<400>  3
atggccgtgg aatctcaggg cggcagacct ctggtgctgg gcctgctgct gtgtgtgctg       60

ggacctgtgg tgtctcacgc cggcaagatc ctgctgatcc ccgtggatgg cagccactgg      120

ctgtctatgc tgggcgccat tcagcagctg cagcagaggg gccacgagat cgtggtgctg      180

gcccctgatg ccagcctgta catcagagat ggcgccttct acaccctgaa aacctacccc      240

gtgcccttcc agcgcgagga cgtgaaagaa agcttcgtgt ccctgggcca caacgtgttc      300

gagaacgaca gcttcctgca gagagtgatc aagacctaca agaagatcaa gaaagacagc      360

gccatgctgc tgagcggctg ctcccatctg ctgcacaaca aagaactgat ggcctccctg      420

gccgagagca gcttcgacgt gatgctgacc gacccattcc tgccctgcag ccctatcgtg      480

gcccagtacc tgagcctgcc taccgtgttc ttcctgcacg ccctgccttg ctccctggaa      540

ttcgaggcca cccagtgccc caaccccttc agctacgtgc ccagaccact gagcagccac      600

agcgaccaca tgacctttct gcagcgcgtg aagaacatgc tgatcgcctt cagccagaac      660

ttcctgtgcg acgtggtgta cagcccctac gctaccctgg ccagcgaatt cctgcagcgg      720

gaagtgaccg tgcaggacct gctgtctagc gccagcgtgt ggctgttccg cagcgacttc      780

gtgaaggact accccagacc catcatgccc aacatggtgt tcgtgggcgg catcaactgc      840

ctgcaccaga accccctgag ccaggaattt gaggcctaca tcaacgccag cggcgagcac      900

ggcatcgtgg tgtttagcct gggcagcatg gtgtccgaga tccccgagaa aaaggccatg      960

gctatcgccg acgccctggg aaagatcccc cagacagtgc tgtggcggta caccggcacc     1020

agacccagca acctggccaa caacaccatc ctcgtgaaat ggctgcccca gaacgacctg     1080

ctgggccacc ctatgacccg ggcctttatc acacacgccg gctcccatgg cgtgtacgag     1140

agcatctgca acggcgtgcc catggtcatg atgcccctgt tcggcgacca gatggacaac     1200

gccaagcgga tggaaacaaa gggcgctggc gtgaccctga acgtgctgga aatgaccagc     1260

gaggacctgg aaaacgccct gaaggccgtg atcaacgaca agagctacaa agaaaacatc     1320

atgcggctgt ccagcctgca caaggacaga cccgtggaac ccctggacct ggccgtgttc     1380

tgggtggaat tcgtgatgcg gcacaagggc gctccccatc tgaggcctgc agctcacgac     1440

ctgacctggt atcagtacca cagcctggac gtgatcggct tcctgctggc agtggtgctg     1500

accgtggcct tcatcacctt caagtgctgc gcctacggct accggaagtg cctgggcaag     1560

aaaggcagag tgaagaaggc ccacaagagc aagacccact ga                        1602


<210>  4
<211>  397
<212>  DNA
<213>  homo sapiens

<400>  4
gatcttgcta ccagtggaac agccactaag gattctgcag tgagagcaga gggccagcta       60

agtggtactc tcccagagac tgtctgactc acgccacccc ctccaccttg gacacaggac      120

gctgtggttt ctgagccagg tacaatgact cctttcggta agtgcagtgg aagctgtaca      180

ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact      240

tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct      300

cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct      360

cagcttcagg caccaccact gacctgggac agtgaat                               397


<210>  5
<211>  441
<212>  DNA
<213>  artificial

<220>
<223>  HBB2 intron

<400>  5
gtacacatat tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt       60

cttttaatat acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca      120

gggcaataat gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata      180

atttctgggt taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt      240

aactgatgta agaggtttca tattgctaat agcagctaca atccagctac cattctgctt      300

ttattttatg gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa      360

tcatgttcat acctcttatc ttcctcccac agctcctggg caacgtgctg gtctgtgtgc      420

tggcccatca ctttggcaaa g                                                441


<210>  6
<211>  441
<212>  DNA
<213>  artificial

<220>
<223>  modified HBB2 intron

<400>  6
gtacacatat tgaccaaatc agggtaattt tgcatttgta attttaaaaa atgctttctt       60

cttttaatat acttttttgt ttatcttatt tctaatactt tccctaatct ctttctttca      120

gggcaataat gatacaatgt atcatgcctc tttgcaccat tctaaagaat aacagtgata      180

atttctgggt taaggcaata gcaatatttc tgcatataaa tatttctgca tataaattgt      240

aactgatgta agaggtttca tattgctaat agcagctaca atccagctac cattctgctt      300

ttattttctg gttgggataa ggctggatta ttctgagtcc aagctaggcc cttttgctaa      360

tcttgttcat acctcttatc ttcctcccac agctcctggg caacctgctg gtctctctgc      420

tggcccatca ctttggcaaa g                                                441


<210>  7
<211>  1438
<212>  DNA
<213>  artificial

<220>
<223>  FIX intron

<400>  7
ggtttgtttc cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct       60

gatgctgtct tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta      120

acagccagca cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc      180

atttttaaaa ctaaatagat cgacaatgct tatgatgcat ttatgtttaa taaacactgt      240

tcagttcatg atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa      300

aaattaaaag tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta      360

tttttgtttg gacttaccac tttgaaatca aaatgggaaa caaaagcaca aacaatggcc      420

ttatttacac aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt      480

aatgaggtgt gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa      540

cataaagatt aacctttcat tagcaagctg ttagttatca ccaacgcttt tcatggatta      600

ggaaaaaatc attttgtctc tatgtcaaac atcttggagt tgatatttgg ggaaacacaa      660

tactcagttg agttccctag gggagaaaag cacgcttaag aattgacata aagagtagga      720

agttagctaa tgcaacatat atcactttgt tttttcacaa ctacagtgac tttatgtatt      780

tcccagagga aggcatacag ggaagaaatt atcccatttg gacaaacagc atgttctcac      840

aggaagcatt tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt      900

accaggatca ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc      960

cactccagac atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt     1020

tcttcaggag acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc     1080

agggtgatgg atcactttgc aaagatcctc aatgagctat tttcaagtga tgacaaagtg     1140

tgaagttaac cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt     1200

agaaatctga ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt     1260

cctaaatctc catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct     1320

aaagagaaat tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta     1380

aaattttcat gatgttttct tttttgctaa aactaaagaa ttattctttt acatttca       1438


<210>  8
<211>  1438
<212>  DNA
<213>  artificial

<220>
<223>  modified FIX intron

<400>  8
ggtttgtttc cttttttaaa atacattgag tatgcttgcc ttttagatat agaaatatct       60

gatgctgtct tcttcactaa attttgatta catgatttga cagcaatatt gaagagtcta      120

acagccagca cgcaggttgg taagtactgg ttctttgtta gctaggtttt cttcttcttc      180

atttttaaaa ctaaatagat cgacattgct tttgttgcat ttatgtttaa taaacactgt      240

tcagttcatg atttggtcat gtaattcctg ttagaaaaca ttcatctcct tggtttaaaa      300

aaattaaaag tgggaaaaca aagaaatagc agaatatagt gaaaaaaaat aaccacatta      360

tttttgtttg gacttaccac tttgaaatca aattgggaaa caaaagcaca aacaatggcc      420

ttatttacac aaaaagtctg attttaagat atatgacatt tcaaggtttc agaagtatgt      480

aatgaggtgt gtctctaatt ttttaaatta tatatcttca atttaaagtt ttagttaaaa      540

cataaagatt aacctttcat tagcaagctg ttagttatca ccaacgcttt tcatggatta      600

ggaaaaaatc attttgtctc tttgtcaaac atcttggagt tgatatttgg ggaaacacaa      660

tactcagttg agttccctag gggagaaaag cacgcttaag aattgacata aagagtagga      720

agttagctat tgcaacatat atcactttgt tttttcacaa ctacagtgac tttttgtatt      780

tcccagagga aggcatacag ggaagaaatt atcccatttg gacaaacagc ttgttctcac      840

aggaagcatt tatcacactt acttgtcaac tttctagaat caaatctagt agctgacagt      900

accaggatca ggggtgccaa ccctaagcac ccccagaaag ctgactggcc ctgtggttcc      960

cactccagac atgatgtcag ctgtgaaatc gacgtcgctg gaccataatt aggcttctgt     1020

tcttcaggag acatttgttc aaagtcattt gggcaaccat attctgaaaa cagcccagcc     1080

agggtgttgg atcactttgc aaagatcctc attgagctat tttcaagtgt tgacaaagtg     1140

tgaagttaac cgctcatttg agaactttct ttttcatcca aagtaaattc aaatatgatt     1200

agaaatctga ccttttatta ctggaattct cttgactaaa agtaaaattg aattttaatt     1260

cctaaatctc catgtgtata cagtactgtg ggaacatcac agattttggc tccatgccct     1320

aaagagaaat tggctttcag attatttgga ttaaaaacaa agactttctt aagagatgta     1380

aaattttctt gttgttttct tttttgctaa aactaaagaa ttattctttt acatttca       1438


<210>  9
<211>  881
<212>  DNA
<213>  artificial

<220>
<223>  chicken beta-globin intron

<400>  9
gcgggagtcg ctgcgttgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc       60

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      120

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      180

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      240

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      300

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg      360

gggcggtgcc ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt      420

gtgcgtgggg gggtgagcag ggggtgtggg cgcgtcggtc gggctgcaac cccccctgca      480

cccccctccc cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg      540

tggcgcgggg ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc      600

ggggccgcct cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg      660

cggctgtcga ggcgcggcga gccgcagcca ttgcctttta tggtaatcgt gcgagagggc      720

gcagggactt cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac      780

cccctctagc gggcgcgggg cgaagcggtg cggcgccggc aggaaggaaa tgggcgggga      840

gggccttcgt gcgtcgccgc gccgccgtcc ccttctccct c                          881


<210>  10
<211>  881
<212>  DNA
<213>  artificial

<220>
<223>  optimized chicken beta-globin intron

<400>  10
gcgggagtcg ctgcgttgcc ttcgccccgt gccccgctcc gccgccgcct cgcgccgccc       60

gccccggctc tgactgaccg cgttactccc acaggtgagc gggcgggacg gcccttctcc      120

tccgggctgt aattagcgct tggtttaatg acggcttgtt tcttttctgt ggctgcgtga      180

aagccttgag gggctccggg agggcccttt gtgcgggggg agcggctcgg ggggtgcgtg      240

cgtgtgtgtg tgcgtgggga gcgccgcgtg cggctccgcg ctgcccggcg gctgtgagcg      300

ctgcgggcgc ggcgcggggc tttgtgcgct ccgcagtgtg cgcgagggga gcgcggccgg      360

gggcggtgcc ccgcggtgcg gggggggctg cgaggggaac aaaggctgcg tgcggggtgt      420

gtgcgtgggg gggtgagcag ggggtgtggg cgcgtcggtc gggctgcaac cccccctgca      480

cccccctccc cgagttgctg agcacggccc ggcttcgggt gcggggctcc gtacggggcg      540

tggcgcgggg ctcgccgtgc cgggcggggg gtggcggcag gtgggggtgc cgggcggggc      600

ggggccgcct cgggccgggg agggctcggg ggaggggcgc ggcggccccc ggagcgccgg      660

cggctgtcga ggcgcggcga gccgcagcca ttgccttttt tggtaatcgt gcgagagggc      720

gcagggactt cctttgtccc aaatctgtgc ggagccgaaa tctgggaggc gccgccgcac      780

cccctctagc gggcgcgggg cgaagcggtg cggcgccggc aggaaggaat tgggcgggga      840

gggccttcgt gcgtcgccgc gccgccgtcc ccttctccct c                          881


<210>  11
<211>  322
<212>  DNA
<213>  artificial

<220>
<223>  ApoE control region

<400>  11
aaggctcaga ggcacacagg agtttctggg ctcaccctgc ccccttccaa cccctcagtt       60

cccatcctcc agcagctgtt tgtgtgctgc ctctgaagtc cacactgaac aaacttcagc      120

ctactcatgt ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct      180

ccctgcctgc tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac      240

ctccaacatc cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg      300

tggtttaggt agtgtgagag gg                                               322


