                         SEQUENCE LISTING

<110>  Evolva SA
 
<120>  Methods for Recombinant Production of Saffron Compounds

<130>  14-113-WO

<150>  US 61/984,582
<151>  2014-04-25

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  1197
<212>  DNA
<213>  Novosphingobium aromaticivorans

<400>  1
atggaagctc cagcccacgt accagccgat agagtcgttg acatcgatat ctacatgcca       60

ccagggttgg ctgaacacgg atttcacaag gcttggtcag acctatctgc aggaaaccca      120

gccgtagtgt ggactcctag aaatgaaggt cattggattg ctcttggtgg tgaggcatta      180

caggaagtac aatccgaccc agagagattc tctagtcgaa tcattgtatt gcctaagtcc      240

gtcggtgaga tgcatggttt aataccaact accattgatc caccagaaca tagaccttat      300

agacaactat tgaatgcaca tctgaaccct ggcgcaataa gaggcctcag tgaatcaatc      360

agacaaacag ctgtggacct aatcgaagga tttgctgctc aagggcattg taactttaca      420

gcacagtacg ccgaacaatt tcctatcaga gtattcatgg cactcgtcgg catcgaagct      480

agcgaagctc caaggatcag acattgggca gaatgcatga ctcgtccagg aatggatatg      540

acattcgatg aagctaaagc ggtgttcttt gactacgttg gtccattagt tgatgctcga      600

agggagacac caggtgaaga tatgatatct gccatgatta atgccgattt gggcgacggg      660

agaagattaa caagagatga agccctttca gtggtcactc aagtccttat agctggattg      720

gatacagttg ttaacgttct cggctttatc atgagagaat tagccgggaa tcctgcgtta      780

agagctgatc tgagacaaag aggcgcagac atccttccag ttgtgcatga actgttcaga      840

agatttggtt tggtttctat tgctagagaa gttagaagag atatcgaatt tcatggtgtt      900

catttgaaag caggcgatat gattgctata ccaacgcaag ttcacggttt agacccaaga      960

gtcaatccag atcctttggc aattgatcct tctcgtaaac gtgctagaca ttccactttc     1020

ggatcaggac ctcacatgtg tcctggtcag gaactggcca ggaaggaggt agcaattacc     1080

ttggaggagt ggttaagacg tattcctgac tttgcattgg gtccaaattc tgatctaagt     1140

cctgtcccag gtattgtggg tgcgctaagg agagtagagc ttgtttggaa cacctaa        1197


<210>  2
<211>  398
<212>  PRT
<213>  Novosphingobium aromaticivorans

<400>  2

Met Glu Ala Pro Ala His Val Pro Ala Asp Arg Val Val Asp Ile Asp 
1               5                   10                  15      


Ile Tyr Met Pro Pro Gly Leu Ala Glu His Gly Phe His Lys Ala Trp 
            20                  25                  30          


Ser Asp Leu Ser Ala Gly Asn Pro Ala Val Val Trp Thr Pro Arg Asn 
        35                  40                  45              


Glu Gly His Trp Ile Ala Leu Gly Gly Glu Ala Leu Gln Glu Val Gln 
    50                  55                  60                  


Ser Asp Pro Glu Arg Phe Ser Ser Arg Ile Ile Val Leu Pro Lys Ser 
65                  70                  75                  80  


Val Gly Glu Met His Gly Leu Ile Pro Thr Thr Ile Asp Pro Pro Glu 
                85                  90                  95      


His Arg Pro Tyr Arg Gln Leu Leu Asn Ala His Leu Asn Pro Gly Ala 
            100                 105                 110         


Ile Arg Gly Leu Ser Glu Ser Ile Arg Gln Thr Ala Val Asp Leu Ile 
        115                 120                 125             


Glu Gly Phe Ala Ala Gln Gly His Cys Asn Phe Thr Ala Gln Tyr Ala 
    130                 135                 140                 


Glu Gln Phe Pro Ile Arg Val Phe Met Ala Leu Val Gly Ile Glu Ala 
145                 150                 155                 160 


Ser Glu Ala Pro Arg Ile Arg His Trp Ala Glu Cys Met Thr Arg Pro 
                165                 170                 175     


Gly Met Asp Met Thr Phe Asp Glu Ala Lys Ala Val Phe Phe Asp Tyr 
            180                 185                 190         


Val Gly Pro Leu Val Asp Ala Arg Arg Glu Thr Pro Gly Glu Asp Met 
        195                 200                 205             


Ile Ser Ala Met Ile Asn Ala Asp Leu Gly Asp Gly Arg Arg Leu Thr 
    210                 215                 220                 


Arg Asp Glu Ala Leu Ser Val Val Thr Gln Val Leu Ile Ala Gly Leu 
225                 230                 235                 240 


Asp Thr Val Val Asn Val Leu Gly Phe Ile Met Arg Glu Leu Ala Gly 
                245                 250                 255     


Asn Pro Ala Leu Arg Ala Asp Leu Arg Gln Arg Gly Ala Asp Ile Leu 
            260                 265                 270         


Pro Val Val His Glu Leu Phe Arg Arg Phe Gly Leu Val Ser Ile Ala 
        275                 280                 285             


Arg Glu Val Arg Arg Asp Ile Glu Phe His Gly Val His Leu Lys Ala 
    290                 295                 300                 


Gly Asp Met Ile Ala Ile Pro Thr Gln Val His Gly Leu Asp Pro Arg 
305                 310                 315                 320 


Val Asn Pro Asp Pro Leu Ala Ile Asp Pro Ser Arg Lys Arg Ala Arg 
                325                 330                 335     


His Ser Thr Phe Gly Ser Gly Pro His Met Cys Pro Gly Gln Glu Leu 
            340                 345                 350         


Ala Arg Lys Glu Val Ala Ile Thr Leu Glu Glu Trp Leu Arg Arg Ile 
        355                 360                 365             


Pro Asp Phe Ala Leu Gly Pro Asn Ser Asp Leu Ser Pro Val Pro Gly 
    370                 375                 380                 


Ile Val Gly Ala Leu Arg Arg Val Glu Leu Val Trp Asn Thr 
385                 390                 395             


<210>  3
<211>  363
<212>  DNA
<213>  Novosphingobium aromaticivorans

<400>  3
atgagggctg actgcatccc acttcattct aagcaagatc ctccattaac agctatactg       60

gttacaacga gagatggtac tagaacagag attcaagccg aaccaggatt gtctttaatg      120

gaagccctta gagatgctgg tatcgatgaa ttgctagcct tgtgtggagg gtgctgctcc      180

tgtgcaacct gtcatgtgtt ggtcgctcct gcgtttgctg atcgtctgcc agcattatct      240

ggcgatgaga acgacctcct agactcaagt gaccatagaa ctcctcacag cagattatca      300

tgtcagatca ctattaatga taaacttgaa ggtttggaag tagaaattgc accagaggat      360

taa                                                                    363


<210>  4
<211>  120
<212>  PRT
<213>  Novosphingobium aromaticivorans

<400>  4

Met Arg Ala Asp Cys Ile Pro Leu His Ser Lys Gln Asp Pro Pro Leu 
1               5                   10                  15      


Thr Ala Ile Leu Val Thr Thr Arg Asp Gly Thr Arg Thr Glu Ile Gln 
            20                  25                  30          


Ala Glu Pro Gly Leu Ser Leu Met Glu Ala Leu Arg Asp Ala Gly Ile 
        35                  40                  45              


Asp Glu Leu Leu Ala Leu Cys Gly Gly Cys Cys Ser Cys Ala Thr Cys 
    50                  55                  60                  


His Val Leu Val Ala Pro Ala Phe Ala Asp Arg Leu Pro Ala Leu Ser 
65                  70                  75                  80  


Gly Asp Glu Asn Asp Leu Leu Asp Ser Ser Asp His Arg Thr Pro His 
                85                  90                  95      


Ser Arg Leu Ser Cys Gln Ile Thr Ile Asn Asp Lys Leu Glu Gly Leu 
            100                 105                 110         


Glu Val Glu Ile Ala Pro Glu Asp 
        115                 120 


<210>  5
<211>  1248
<212>  DNA
<213>  Novosphingobium aromaticivorans

<400>  5
atggccagcg aagtacaagc cgaaagagca gacgtggtca tagttggagc tgggcacggt       60

ggtgcacaag ccgcgattgc actaagacag aatggctttg aagggagagt cctagtgatc      120

ggtcgtgaac cagaaatccc ttacgaacgt ccaccattat ctaaagagta tttggctaga      180

gagaagacat ttgaaaggat ctgcatccgt cctgctcaat tctgggagga taaagccgtt      240

gaaatgaaac ttggtgctga ggttgtatcc ctggacccag ctgcccatac agtcaaattg      300

ggcgatgggt cagctattga atatgggaag ttgatttggg ctacaggagg tgacccaagg      360

agactgtctt gtgtcggagc tgatttggca ggcgtccatg ctgttagaac aaaggaagat      420

gcggatagac tcatggccga attggatgca ggagccaaga acgctgtggt tattggtggc      480

ggttacatcg gtttagaagc agctgcagtt ctaaccaagt ttggagtcaa tgttacactc      540

ttagaagcat tgccaagagt attagctaga gttgccggtg aagccctaag tgagttctac      600

caagccgaac atagagccca cggcgttgat cttagaacag gtgctgctat ggactgcata      660

gagggagatg gtactaaagt aactggtgtt agaatgcagg atggttctgt aatccctgct      720

gacatcgtaa ttgtgggaat tggtatcgta ccttgtgtgg gcgctttgat atcagccgga      780

gcaagtggcg gtaatggtgt tgacgttgat gagttctgta gaacatctct gaccgatgtc      840

tacgctattg gagattgtgc agctcacgct aatgactttg ctgacggcgc tgtcatcaga      900

ttggaatctg tgcagaacgc aaatgatatg gccaccgcag cagccaaaga tatttgtggt      960

gcacctgtgc catataaagc cactccatgg ttctggtcta accaatacga tctgaaattg     1020

caaacggttg gtctgtcaac tggccatgat aacgcggtat tacgaggcga cccagcaact     1080

agatccttct cagttgtata cttaaaggga ggcaaagttg ttgctcttga ctgcgtcaat     1140

atggttaaag attacgtgca aggcaagaaa ttggtcgaag caagagctca aatagcacct     1200

gaacaactag ctgatgcggg agttccactt aaggaaatgt tagcgtaa                  1248


<210>  6
<211>  415
<212>  PRT
<213>  Novosphingobium aromaticivorans

<400>  6

Met Ala Ser Glu Val Gln Ala Glu Arg Ala Asp Val Val Ile Val Gly 
1               5                   10                  15      


Ala Gly His Gly Gly Ala Gln Ala Ala Ile Ala Leu Arg Gln Asn Gly 
            20                  25                  30          


Phe Glu Gly Arg Val Leu Val Ile Gly Arg Glu Pro Glu Ile Pro Tyr 
        35                  40                  45              


Glu Arg Pro Pro Leu Ser Lys Glu Tyr Leu Ala Arg Glu Lys Thr Phe 
    50                  55                  60                  


Glu Arg Ile Cys Ile Arg Pro Ala Gln Phe Trp Glu Asp Lys Ala Val 
65                  70                  75                  80  


Glu Met Lys Leu Gly Ala Glu Val Val Ser Leu Asp Pro Ala Ala His 
                85                  90                  95      


Thr Val Lys Leu Gly Asp Gly Ser Ala Ile Glu Tyr Gly Lys Leu Ile 
            100                 105                 110         


Trp Ala Thr Gly Gly Asp Pro Arg Arg Leu Ser Cys Val Gly Ala Asp 
        115                 120                 125             


Leu Ala Gly Val His Ala Val Arg Thr Lys Glu Asp Ala Asp Arg Leu 
    130                 135                 140                 


Met Ala Glu Leu Asp Ala Gly Ala Lys Asn Ala Val Val Ile Gly Gly 
145                 150                 155                 160 


Gly Tyr Ile Gly Leu Glu Ala Ala Ala Val Leu Thr Lys Phe Gly Val 
                165                 170                 175     


Asn Val Thr Leu Leu Glu Ala Leu Pro Arg Val Leu Ala Arg Val Ala 
            180                 185                 190         


Gly Glu Ala Leu Ser Glu Phe Tyr Gln Ala Glu His Arg Ala His Gly 
        195                 200                 205             


Val Asp Leu Arg Thr Gly Ala Ala Met Asp Cys Ile Glu Gly Asp Gly 
    210                 215                 220                 


Thr Lys Val Thr Gly Val Arg Met Gln Asp Gly Ser Val Ile Pro Ala 
225                 230                 235                 240 


Asp Ile Val Ile Val Gly Ile Gly Ile Val Pro Cys Val Gly Ala Leu 
                245                 250                 255     


Ile Ser Ala Gly Ala Ser Gly Gly Asn Gly Val Asp Val Asp Glu Phe 
            260                 265                 270         


Cys Arg Thr Ser Leu Thr Asp Val Tyr Ala Ile Gly Asp Cys Ala Ala 
        275                 280                 285             


His Ala Asn Asp Phe Ala Asp Gly Ala Val Ile Arg Leu Glu Ser Val 
    290                 295                 300                 


Gln Asn Ala Asn Asp Met Ala Thr Ala Ala Ala Lys Asp Ile Cys Gly 
305                 310                 315                 320 


Ala Pro Val Pro Tyr Lys Ala Thr Pro Trp Phe Trp Ser Asn Gln Tyr 
                325                 330                 335     


Asp Leu Lys Leu Gln Thr Val Gly Leu Ser Thr Gly His Asp Asn Ala 
            340                 345                 350         


Val Leu Arg Gly Asp Pro Ala Thr Arg Ser Phe Ser Val Val Tyr Leu 
        355                 360                 365             


Lys Gly Gly Lys Val Val Ala Leu Asp Cys Val Asn Met Val Lys Asp 
    370                 375                 380                 


Tyr Val Gln Gly Lys Lys Leu Val Glu Ala Arg Ala Gln Ile Ala Pro 
385                 390                 395                 400 


Glu Gln Leu Ala Asp Ala Gly Val Pro Leu Lys Glu Met Leu Ala 
                405                 410                 415 


<210>  7
<211>  1470
<212>  DNA
<213>  Stevia rebaudiana

<400>  7
atggctagag tcgatagagc cacaaacctt cacttcgtct tgtttccgct actgactcca       60

ggtcatatga tacccatggt cgacatagcc cggttactag ccgaacgcgg ttcaacggta      120

accataatca ccacaccact gaacgcgaac cgtttcaaac cggtcattgc tcgggccatc      180

aaagaccgcc tcaagatcca agttcttgaa ctcaaactcc cctcaaccga aggtttaccc      240

gaaggatgcg agaattttga catgatcgaa tcggctcagt tttttcataa aatgttcgag      300

gcaacatata agttagccga acccgcggtt aacgcggtcc agagactaac tccaccacca      360

agttgcatca ttgctgataa tcttttacct tggacaaatg atttagccca aaagtttaaa      420

attccaagaa ttgtttttca tgggcccgga tgcttcacaa tcttatgcat acatattgca      480

atgaatagta acgtgttata tgacatcggg tccgattcgg agcgtatctt gctaccgggt      540

ttaccggacc gtattgagct aaccaaagga caagctttga gttgggggag gaaagacaca      600

aaggaagccg cgagtttttg gaaccgcgtg caacgagacg aagatttcgc aaatgggatc      660

gtggttaata gttttcacgc gttggaacct tactatgttg aagagcttgc aaaggtgaaa      720

ggtaagaaag tttggtgtat tgggccggtt tcgttatgta acaaaagttt cgaagatata      780

gccgagagag gaaacaaggg agcgattgat gaacatgaat gtttgaaatg gttagattcg      840

atggagtcac ggtcagtgat attcgtgtgt ttggggagtc tggttcgtgt tgggaccgag      900

caaaacattg acctcgggtt agggttggag gcatcgaaga aaccgttttt gtggtgccta      960

cgacatacaa ccgaagaatt cgaaagatgg ttgtcggagc aagggtatga agaaagggtg     1020

aaagatagag ggctaataat ccgtgggtgg gccccacaag tttttatttt gtcgcaccga     1080

gccattggtg ggtttttaac acattgtggg tggaactcga ctcttgaagg gattacagct     1140

ggagtcccta tggttacatg gcctcagttt acggaccagt ttataaacga aagatttatt     1200

gtagatgttt tgaagatcgg agtgaaaggc ggtatggagg ttccggttgt cgttggagat     1260

caagataagt ttggtgtgtt ggtgaacaaa gaagagatca cgcgatcgat cgaagatcta     1320

atggacgaag gtgaggaagg tgaaacaaga agaaggagaa gtagagaact acgcgatatg     1380

gcaaaaagcg cgatggagga tggaggttca tcgcatcgcg atatgacatc aatgattcag     1440

gatattgtcg agttgtgcaa aaatcgttaa                                      1470


<210>  8
<211>  489
<212>  PRT
<213>  Stevia rebaudiana

<400>  8

Met Ala Arg Val Asp Arg Ala Thr Asn Leu His Phe Val Leu Phe Pro 
1               5                   10                  15      


Leu Leu Thr Pro Gly His Met Ile Pro Met Val Asp Ile Ala Arg Leu 
            20                  25                  30          


Leu Ala Glu Arg Gly Ser Thr Val Thr Ile Ile Thr Thr Pro Leu Asn 
        35                  40                  45              


Ala Asn Arg Phe Lys Pro Val Ile Ala Arg Ala Ile Lys Asp Arg Leu 
    50                  55                  60                  


Lys Ile Gln Val Leu Glu Leu Lys Leu Pro Ser Thr Glu Gly Leu Pro 
65                  70                  75                  80  


Glu Gly Cys Glu Asn Phe Asp Met Ile Glu Ser Ala Gln Phe Phe His 
                85                  90                  95      


Lys Met Phe Glu Ala Thr Tyr Lys Leu Ala Glu Pro Ala Val Asn Ala 
            100                 105                 110         


Val Gln Arg Leu Thr Pro Pro Pro Ser Cys Ile Ile Ala Asp Asn Leu 
        115                 120                 125             


Leu Pro Trp Thr Asn Asp Leu Ala Gln Lys Phe Lys Ile Pro Arg Ile 
    130                 135                 140                 


Val Phe His Gly Pro Gly Cys Phe Thr Ile Leu Cys Ile His Ile Ala 
145                 150                 155                 160 


Met Asn Ser Asn Val Leu Tyr Asp Ile Gly Ser Asp Ser Glu Arg Ile 
                165                 170                 175     


Leu Leu Pro Gly Leu Pro Asp Arg Ile Glu Leu Thr Lys Gly Gln Ala 
            180                 185                 190         


Leu Ser Trp Gly Arg Lys Asp Thr Lys Glu Ala Ala Ser Phe Trp Asn 
        195                 200                 205             


Arg Val Gln Arg Asp Glu Asp Phe Ala Asn Gly Ile Val Val Asn Ser 
    210                 215                 220                 


Phe His Ala Leu Glu Pro Tyr Tyr Val Glu Glu Leu Ala Lys Val Lys 
225                 230                 235                 240 


Gly Lys Lys Val Trp Cys Ile Gly Pro Val Ser Leu Cys Asn Lys Ser 
                245                 250                 255     


Phe Glu Asp Ile Ala Glu Arg Gly Asn Lys Gly Ala Ile Asp Glu His 
            260                 265                 270         


Glu Cys Leu Lys Trp Leu Asp Ser Met Glu Ser Arg Ser Val Ile Phe 
        275                 280                 285             


Val Cys Leu Gly Ser Leu Val Arg Val Gly Thr Glu Gln Asn Ile Asp 
    290                 295                 300                 


Leu Gly Leu Gly Leu Glu Ala Ser Lys Lys Pro Phe Leu Trp Cys Leu 
305                 310                 315                 320 


Arg His Thr Thr Glu Glu Phe Glu Arg Trp Leu Ser Glu Gln Gly Tyr 
                325                 330                 335     


Glu Glu Arg Val Lys Asp Arg Gly Leu Ile Ile Arg Gly Trp Ala Pro 
            340                 345                 350         


Gln Val Phe Ile Leu Ser His Arg Ala Ile Gly Gly Phe Leu Thr His 
        355                 360                 365             


Cys Gly Trp Asn Ser Thr Leu Glu Gly Ile Thr Ala Gly Val Pro Met 
    370                 375                 380                 


Val Thr Trp Pro Gln Phe Thr Asp Gln Phe Ile Asn Glu Arg Phe Ile 
385                 390                 395                 400 


Val Asp Val Leu Lys Ile Gly Val Lys Gly Gly Met Glu Val Pro Val 
                405                 410                 415     


Val Val Gly Asp Gln Asp Lys Phe Gly Val Leu Val Asn Lys Glu Glu 
            420                 425                 430         


Ile Thr Arg Ser Ile Glu Asp Leu Met Asp Glu Gly Glu Glu Gly Glu 
        435                 440                 445             


Thr Arg Arg Arg Arg Ser Arg Glu Leu Arg Asp Met Ala Lys Ser Ala 
    450                 455                 460                 


Met Glu Asp Gly Gly Ser Ser His Arg Asp Met Thr Ser Met Ile Gln 
465                 470                 475                 480 


Asp Ile Val Glu Leu Cys Lys Asn Arg 
                485                 


<210>  9
<211>  30
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  9
gtttcgaata aacacacata aacaaacaaa                                        30


<210>  10
<211>  30
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  10
acaaacacaa atacacacac taaattaata                                        30


<210>  11
<211>  30
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  11
tttcaagcta taccaagcat acaatcaact                                        30


<210>  12
<211>  30
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  12
ccaagcatac aatcaactat ctcatataca                                        30


<210>  13
<211>  30
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  13
ttatctactt tttacaacaa atataaaaca                                        30


<210>  14
<211>  30
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  14
gatacaggat acagcggaaa caacttttaa                                        30


<210>  15
<211>  30
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  15
accatcaaag gaagctttaa tcttctcata                                        30


<210>  16
<211>  1827
<212>  DNA
<213>  Microcystis aeruginosa

<400>  16
atgtcaatta aagacacagt tcaaaataca gttaatgttt ctaacttttc tagatcacaa       60

ctaggtcaac cagatgaaaa caatttgtac caagctgtcg cgactattac agaaggtaga      120

tggcctgaaa acttatccgg ttatgtgttc atcgtctgcc cttttcatcg taaaaatgat      180

aggcacttat tttcaggaga aggtgttatt atcaaatggg atttgcaggg taaaaacaat      240

caagtcaatg tgtattccaa gaagttgaaa acttgggact ccttctggag aaaagttttg      300

ccaatcttta acatctctca agctacattt cctgctgtcg tgagtatatt aggatgctct      360

gaaattgcta acacagctat gataaaactt gaaaaagtag cagaggacca acagttggag      420

gaaacaagat tgatcttgac agccgatgct ggccgttact gggaagtaga tccagtatct      480

ttggatacta ttacaccaat cgggtacttt gatcaacata ttgtgagcgt cccactttca      540

ttctttccag tcctggaaaa taccgcccat ccattttacg ataaaaagac gaaggagttc      600

atcacctgtg aattgaagct aaaactggtt tctggtggta tgctcaaaga tttggacaaa      660

tctgcttaca ttgtgttgtg ggatcaacaa aagcaactta agccttggaa actgcaaggt      720

gccatcctgg atggtagccc acactctgtt atcgttaccg aagattacat tatgatacca      780

gacatgccat tccagatggg agttgcaaaa ctcctaggta tcaggataaa gcctgaggaa      840

acttacccta agacacaaat ctacctagtt aaaagacaag acttaaagga agaggaaact      900

actgtgccat ctcaactcat tacattcaat ggagactctt accattttct ctgtaattat      960

cattctacaa atggtcaaat acaattagta gctattcaaa acgcaactat tagtttgaca     1020

gaagcgatcg aaaaggacga tatacaacat tttactggac aaggctatcc tcctgaatac     1080

cacggcattc cttggatgtt ttcctttgat ccaggagtat tgagaaaggt agtaattgaa     1140

gatgcaagag ttatgtctga acaggctttc atacatccag gttggttctc tacaactctc     1200

tacaccgccg accctagaga atctgagcaa ggctactcag cgatctacca ggtgtatgct     1260

ggatatgtca gagaactgat ctgtagaagg cagtacatgg attttagaga tcaatcaaat     1320

agaatcctta gagatgctga gttaccatgc cacgatctac catctgttct agcaaaagtc     1380

tccttcgata aagactggaa ccaattgaca gaacaaatat cccaagagaa aaaggcctct     1440

aatactcatg tcagtcatct tggtagaggc ctgttagatt tttacgtttg tcctgatggg     1500

tatattctag actcaatcca attcatccca caggagcagg gctacttgtt caccactgtc     1560

cttacaccta ctagagtgtt agaagcatgg ttgttcaacc cagataactt gaaggatggc     1620

ccaattgcta aactaagttt accagaggac gtacattttg ggtttacgct gcactcagaa     1680

tactttgaac aagtacttcc ttcaccaaga ccaagtgtgt cacaagttaa tcgagtttta     1740

agcgcactta gatcattagt tttagtacct gttgaatttt tcctaggtcg tccagcagcc     1800

atctacaata gacaagttaa aaagtaa                                         1827


<210>  17
<211>  608
<212>  PRT
<213>  Microcystis aeruginosa

<400>  17

Met Ser Ile Lys Asp Thr Val Gln Asn Thr Val Asn Val Ser Asn Phe 
1               5                   10                  15      


Ser Arg Ser Gln Leu Gly Gln Pro Asp Glu Asn Asn Leu Tyr Gln Ala 
            20                  25                  30          


Val Ala Thr Ile Thr Glu Gly Arg Trp Pro Glu Asn Leu Ser Gly Tyr 
        35                  40                  45              


Val Phe Ile Val Cys Pro Phe His Arg Lys Asn Asp Arg His Leu Phe 
    50                  55                  60                  


Ser Gly Glu Gly Val Ile Ile Lys Trp Asp Leu Gln Gly Lys Asn Asn 
65                  70                  75                  80  


Gln Val Asn Val Tyr Ser Lys Lys Leu Lys Thr Trp Asp Ser Phe Trp 
                85                  90                  95      


Arg Lys Val Leu Pro Ile Phe Asn Ile Ser Gln Ala Thr Phe Pro Ala 
            100                 105                 110         


Val Val Ser Ile Leu Gly Cys Ser Glu Ile Ala Asn Thr Ala Met Ile 
        115                 120                 125             


Lys Leu Glu Lys Val Ala Glu Asp Gln Gln Leu Glu Glu Thr Arg Leu 
    130                 135                 140                 


Ile Leu Thr Ala Asp Ala Gly Arg Tyr Trp Glu Val Asp Pro Val Ser 
145                 150                 155                 160 


Leu Asp Thr Ile Thr Pro Ile Gly Tyr Phe Asp Gln His Ile Val Ser 
                165                 170                 175     


Val Pro Leu Ser Phe Phe Pro Val Leu Glu Asn Thr Ala His Pro Phe 
            180                 185                 190         


Tyr Asp Lys Lys Thr Lys Glu Phe Ile Thr Cys Glu Leu Lys Leu Lys 
        195                 200                 205             


Leu Val Ser Gly Gly Met Leu Lys Asp Leu Asp Lys Ser Ala Tyr Ile 
    210                 215                 220                 


Val Leu Trp Asp Gln Gln Lys Gln Leu Lys Pro Trp Lys Leu Gln Gly 
225                 230                 235                 240 


Ala Ile Leu Asp Gly Ser Pro His Ser Val Ile Val Thr Glu Asp Tyr 
                245                 250                 255     


Ile Met Ile Pro Asp Met Pro Phe Gln Met Gly Val Ala Lys Leu Leu 
            260                 265                 270         


Gly Ile Arg Ile Lys Pro Glu Glu Thr Tyr Pro Lys Thr Gln Ile Tyr 
        275                 280                 285             


Leu Val Lys Arg Gln Asp Leu Lys Glu Glu Glu Thr Thr Val Pro Ser 
    290                 295                 300                 


Gln Leu Ile Thr Phe Asn Gly Asp Ser Tyr His Phe Leu Cys Asn Tyr 
305                 310                 315                 320 


His Ser Thr Asn Gly Gln Ile Gln Leu Val Ala Ile Gln Asn Ala Thr 
                325                 330                 335     


Ile Ser Leu Thr Glu Ala Ile Glu Lys Asp Asp Ile Gln His Phe Thr 
            340                 345                 350         


Gly Gln Gly Tyr Pro Pro Glu Tyr His Gly Ile Pro Trp Met Phe Ser 
        355                 360                 365             


Phe Asp Pro Gly Val Leu Arg Lys Val Val Ile Glu Asp Ala Arg Val 
    370                 375                 380                 


Met Ser Glu Gln Ala Phe Ile His Pro Gly Trp Phe Ser Thr Thr Leu 
385                 390                 395                 400 


Tyr Thr Ala Asp Pro Arg Glu Ser Glu Gln Gly Tyr Ser Ala Ile Tyr 
                405                 410                 415     


Gln Val Tyr Ala Gly Tyr Val Arg Glu Leu Ile Cys Arg Arg Gln Tyr 
            420                 425                 430         


Met Asp Phe Arg Asp Gln Ser Asn Arg Ile Leu Arg Asp Ala Glu Leu 
        435                 440                 445             


Pro Cys His Asp Leu Pro Ser Val Leu Ala Lys Val Ser Phe Asp Lys 
    450                 455                 460                 


Asp Trp Asn Gln Leu Thr Glu Gln Ile Ser Gln Glu Lys Lys Ala Ser 
465                 470                 475                 480 


Asn Thr His Val Ser His Leu Gly Arg Gly Leu Leu Asp Phe Tyr Val 
                485                 490                 495     


Cys Pro Asp Gly Tyr Ile Leu Asp Ser Ile Gln Phe Ile Pro Gln Glu 
            500                 505                 510         


Gln Gly Tyr Leu Phe Thr Thr Val Leu Thr Pro Thr Arg Val Leu Glu 
        515                 520                 525             


Ala Trp Leu Phe Asn Pro Asp Asn Leu Lys Asp Gly Pro Ile Ala Lys 
    530                 535                 540                 


Leu Ser Leu Pro Glu Asp Val His Phe Gly Phe Thr Leu His Ser Glu 
545                 550                 555                 560 


Tyr Phe Glu Gln Val Leu Pro Ser Pro Arg Pro Ser Val Ser Gln Val 
                565                 570                 575     


Asn Arg Val Leu Ser Ala Leu Arg Ser Leu Val Leu Val Pro Val Glu 
            580                 585                 590         


Phe Phe Leu Gly Arg Pro Ala Ala Ile Tyr Asn Arg Gln Val Lys Lys 
        595                 600                 605             


<210>  18
<211>  1833
<212>  DNA
<213>  Microcystis aeruginosa

<400>  18
atgaacatgt caaataagga cacagtgcaa aatactgtta acgtgtccaa ttttagtaga       60

agccagctcg gtagaccaga tgaaaacaat ctgtacaaag ccgtggcaac tatagccgaa      120

ggccattggc cagaaaactt aagtggctat gttttcatag tctgcccttt tcacagaaag      180

aatgacagac atttgttttc tggtgaagga gttatcatta agtgggatct gcaagggaaa      240

aacaatcaag tgaatgtgta ctccaaaaag ctgaaaacat gggattcatt ttggagaaag      300

gtgctaccta tctttaacat ttcacaagca acatttcctg ctgttgtctc aatcttaggt      360

tgttcagaaa ttgctaatac tgctatggtc aaattggaga aagtcagtga agataaacag      420

ttggaagaga caagactaat tctcactgct gatgctggca gatactggga agtagaccca      480

gtcagcctag acaccattac tccaataggt tactttgacc aacatattgt ttccgttcct      540

ctctctattt tccctgtact tgaaaataca gctcatcctt tttacgacaa aaagacgcag      600

gagttcataa catgcgaatt gaaattgaag ttgatctctg gagggatgtt aaaagatttg      660

gacaaatctg tctacatcgt attgtgggat caacaaaagc aattaaagcc ttggaagctc      720

caaggtgcaa tcttggatgg ttctccacat tcagttattg tgactgaaga ttacatcatg      780

atcccagata tgccatttca aatgggcgtc gccaaattac ttgggatcag aattaaacca      840

gaagagactt acccaaaaac ccaaatatac ttagtgaaaa gacaagattt gaaagaggaa      900

gagactacgg ttccatccag gctcattaca ttcaatggtg actcttatca cttcctatgc      960

aattaccact caacaaatgg tcagatccaa cttgtagcca tccaaaacgc tacaatttca     1020

cttactgaag caattgaaaa agacgatatc caacatttca cgggtcaggg ttatccacct     1080

gaataccacg gtattccttg gatgttctct tttgatccag gcgttttgag aaaagttgtc     1140

attgaagatg ctagagttat gtctgaacag gcttttatcc atccaggttg gttcagtaca     1200

accttataca cagcagatcc acgtgagttg gaacaaggat actctgcgat atatcaagta     1260

tatgcgggct acgttagaga actaatctgt agacgacaat atatggattg tagggatcaa     1320

tctaacagaa tcttacgtga tgctgaactt ccttgtcatg acttgccatc tgtgttggca     1380

aaggttccat tcgataagga ctggaatcaa ttaacagaac aaatttctca agagaaaaag     1440

gcatcagaca cacatgtctc acatctgggc cgtggattat tggactttta cgtgtgtcca     1500

gatggatata tcttagattc tatacaattc ataccacaag agcagggata tctgttaaca     1560

actgttttaa cacctactag agtactagaa gcctggttgt ttaacccaga taatttgaaa     1620

gatggaccta tcgctaagtt gagcctacca gaggatgttc actttggttt taccctgcac     1680

tcagagtact ttgaacaggt acttccttct ccaagaccat ctgtttccca agtcaataga     1740

gttttgtcag ccttaaggtc ccttgtatta gttcctgtag aatttttcct agggaaacca     1800

gcagccatct acaacagaca agttaaaaag taa                                  1833


<210>  19
<211>  610
<212>  PRT
<213>  Microcystis aeruginosa

<400>  19

Met Asn Met Ser Asn Lys Asp Thr Val Gln Asn Thr Val Asn Val Ser 
1               5                   10                  15      


Asn Phe Ser Arg Ser Gln Leu Gly Arg Pro Asp Glu Asn Asn Leu Tyr 
            20                  25                  30          


Lys Ala Val Ala Thr Ile Ala Glu Gly His Trp Pro Glu Asn Leu Ser 
        35                  40                  45              


Gly Tyr Val Phe Ile Val Cys Pro Phe His Arg Lys Asn Asp Arg His 
    50                  55                  60                  


Leu Phe Ser Gly Glu Gly Val Ile Ile Lys Trp Asp Leu Gln Gly Lys 
65                  70                  75                  80  


Asn Asn Gln Val Asn Val Tyr Ser Lys Lys Leu Lys Thr Trp Asp Ser 
                85                  90                  95      


Phe Trp Arg Lys Val Leu Pro Ile Phe Asn Ile Ser Gln Ala Thr Phe 
            100                 105                 110         


Pro Ala Val Val Ser Ile Leu Gly Cys Ser Glu Ile Ala Asn Thr Ala 
        115                 120                 125             


Met Val Lys Leu Glu Lys Val Ser Glu Asp Lys Gln Leu Glu Glu Thr 
    130                 135                 140                 


Arg Leu Ile Leu Thr Ala Asp Ala Gly Arg Tyr Trp Glu Val Asp Pro 
145                 150                 155                 160 


Val Ser Leu Asp Thr Ile Thr Pro Ile Gly Tyr Phe Asp Gln His Ile 
                165                 170                 175     


Val Ser Val Pro Leu Ser Ile Phe Pro Val Leu Glu Asn Thr Ala His 
            180                 185                 190         


Pro Phe Tyr Asp Lys Lys Thr Gln Glu Phe Ile Thr Cys Glu Leu Lys 
        195                 200                 205             


Leu Lys Leu Ile Ser Gly Gly Met Leu Lys Asp Leu Asp Lys Ser Val 
    210                 215                 220                 


Tyr Ile Val Leu Trp Asp Gln Gln Lys Gln Leu Lys Pro Trp Lys Leu 
225                 230                 235                 240 


Gln Gly Ala Ile Leu Asp Gly Ser Pro His Ser Val Ile Val Thr Glu 
                245                 250                 255     


Asp Tyr Ile Met Ile Pro Asp Met Pro Phe Gln Met Gly Val Ala Lys 
            260                 265                 270         


Leu Leu Gly Ile Arg Ile Lys Pro Glu Glu Thr Tyr Pro Lys Thr Gln 
        275                 280                 285             


Ile Tyr Leu Val Lys Arg Gln Asp Leu Lys Glu Glu Glu Thr Thr Val 
    290                 295                 300                 


Pro Ser Arg Leu Ile Thr Phe Asn Gly Asp Ser Tyr His Phe Leu Cys 
305                 310                 315                 320 


Asn Tyr His Ser Thr Asn Gly Gln Ile Gln Leu Val Ala Ile Gln Asn 
                325                 330                 335     


Ala Thr Ile Ser Leu Thr Glu Ala Ile Glu Lys Asp Asp Ile Gln His 
            340                 345                 350         


Phe Thr Gly Gln Gly Tyr Pro Pro Glu Tyr His Gly Ile Pro Trp Met 
        355                 360                 365             


Phe Ser Phe Asp Pro Gly Val Leu Arg Lys Val Val Ile Glu Asp Ala 
    370                 375                 380                 


Arg Val Met Ser Glu Gln Ala Phe Ile His Pro Gly Trp Phe Ser Thr 
385                 390                 395                 400 


Thr Leu Tyr Thr Ala Asp Pro Arg Glu Leu Glu Gln Gly Tyr Ser Ala 
                405                 410                 415     


Ile Tyr Gln Val Tyr Ala Gly Tyr Val Arg Glu Leu Ile Cys Arg Arg 
            420                 425                 430         


Gln Tyr Met Asp Cys Arg Asp Gln Ser Asn Arg Ile Leu Arg Asp Ala 
        435                 440                 445             


Glu Leu Pro Cys His Asp Leu Pro Ser Val Leu Ala Lys Val Pro Phe 
    450                 455                 460                 


Asp Lys Asp Trp Asn Gln Leu Thr Glu Gln Ile Ser Gln Glu Lys Lys 
465                 470                 475                 480 


Ala Ser Asp Thr His Val Ser His Leu Gly Arg Gly Leu Leu Asp Phe 
                485                 490                 495     


Tyr Val Cys Pro Asp Gly Tyr Ile Leu Asp Ser Ile Gln Phe Ile Pro 
            500                 505                 510         


Gln Glu Gln Gly Tyr Leu Leu Thr Thr Val Leu Thr Pro Thr Arg Val 
        515                 520                 525             


Leu Glu Ala Trp Leu Phe Asn Pro Asp Asn Leu Lys Asp Gly Pro Ile 
    530                 535                 540                 


Ala Lys Leu Ser Leu Pro Glu Asp Val His Phe Gly Phe Thr Leu His 
545                 550                 555                 560 


Ser Glu Tyr Phe Glu Gln Val Leu Pro Ser Pro Arg Pro Ser Val Ser 
                565                 570                 575     


Gln Val Asn Arg Val Leu Ser Ala Leu Arg Ser Leu Val Leu Val Pro 
            580                 585                 590         


Val Glu Phe Phe Leu Gly Lys Pro Ala Ala Ile Tyr Asn Arg Gln Val 
        595                 600                 605             


Lys Lys 
    610 


<210>  20
<211>  1683
<212>  DNA
<213>  Crocus sativus

<400>  20
atggcaaaca aagaggaagc agaaaagaga aagaagaaac caaagccttt gaaagtacta       60

attacaaaag tagatccaaa accacgtaag ggaatggcat ctgtagctgt tgatttgcta      120

gagaaagcct ttgtttactt actgtacggt aattctgcgg cagacagatc ctctggtaga      180

cgtagacgta aagagcacta ttacttatct ggcaactatg ctcctgtcgg tcatgaaact      240

ccaccttctg accatcttcc agtgcacggg agcctgcctg aatgcttgaa tggagttttc      300

ctaagagtgg gtccaaatcc taagtttgct ccagtcgcag ggtataactg ggtcgatggc      360

gacggtatga ttcatggttt gagaatcaaa gatggtaagg ccacttactt atccagatac      420

atcaaaactt caagattcaa acaagaggaa tactttggta gggccaagtt tatgaaaata      480

ggcgatctta gaggattact aggatttttc acaatactta tcttagtttt gaggacaact      540

ttgaaggtta tcgacatctc ttacggtaga ggcacgggta acaccgcttt agtttatcat      600

aatgggctac ttttagccct ctctgaggaa gataaaccat acgtcgttaa agtgttggaa      660

gatggagact tacaaacgtt aggtattttg gactacgata aaaagttatc tcatccattc      720

actgctcatc caaaaatcga cccattaaca gatgaaatgt tcacattcgg atactcactg      780

tctcctccat atttgactta cagggtaatt tcaaaagatg gtgtgatgca agatccagtc      840

caaatctcaa ttacatctcc tactataatg catgactttg ctatcaccga aaattacgct      900

atctttatgg atcttccatt gtacttccaa ccagaggaaa tggtgaaagg gaaatttgtt      960

tcctcatttc accctacaaa aagagctaga atcggtgttc tccctagata cgcagaagat     1020

gaacatccaa tcagatggtt tgacctgcca agttgtttta tgacccacaa cgccaacgca     1080

tgggaggaaa atgatgaagt cgttttgttt acctgtcgac tcgaatcccc agacctggat     1140

atgttgtcag gtccagcaga agaggaaata gggaatagta agtctgaact gtatgagatg     1200

agattcaatc tcaaaacagg tataacatcc cagaaacaac taagtgtacc ttcagtggat     1260

tttcctagaa ttaaccagtc atacactggt agaaagcaac aatacgttta ctgtactctg     1320

ggaaatacca agattaaggg cattgtgaag tttgatcttc agatcgaacc agaagcgggc     1380

aaaacaatgc ttgaagtagg tggcaatgta caaggtattt ttgaactagg ccctcgaaga     1440

tatggctctg aagctatatt tgtcccatgc caacctggta tcaagagtga cgaagatgat     1500

ggatatttga tctttttcgt tcacgatgaa aacaatggca agagtgaggt caatgttatt     1560

gatgctaaaa caatgtcagc cgaaccagtt gcagtagttc aactaccaag cagagttcct     1620

tacggtttcc atgctttgtt ccttaatgaa gaggagttgc agaaacatca agcggaaaca     1680

taa                                                                   1683


<210>  21
<211>  560
<212>  PRT
<213>  Crocus sativus

<400>  21

Met Ala Asn Lys Glu Glu Ala Glu Lys Arg Lys Lys Lys Pro Lys Pro 
1               5                   10                  15      


Leu Lys Val Leu Ile Thr Lys Val Asp Pro Lys Pro Arg Lys Gly Met 
            20                  25                  30          


Ala Ser Val Ala Val Asp Leu Leu Glu Lys Ala Phe Val Tyr Leu Leu 
        35                  40                  45              


Tyr Gly Asn Ser Ala Ala Asp Arg Ser Ser Gly Arg Arg Arg Arg Lys 
    50                  55                  60                  


Glu His Tyr Tyr Leu Ser Gly Asn Tyr Ala Pro Val Gly His Glu Thr 
65                  70                  75                  80  


Pro Pro Ser Asp His Leu Pro Val His Gly Ser Leu Pro Glu Cys Leu 
                85                  90                  95      


Asn Gly Val Phe Leu Arg Val Gly Pro Asn Pro Lys Phe Ala Pro Val 
            100                 105                 110         


Ala Gly Tyr Asn Trp Val Asp Gly Asp Gly Met Ile His Gly Leu Arg 
        115                 120                 125             


Ile Lys Asp Gly Lys Ala Thr Tyr Leu Ser Arg Tyr Ile Lys Thr Ser 
    130                 135                 140                 


Arg Phe Lys Gln Glu Glu Tyr Phe Gly Arg Ala Lys Phe Met Lys Ile 
145                 150                 155                 160 


Gly Asp Leu Arg Gly Leu Leu Gly Phe Phe Thr Ile Leu Ile Leu Val 
                165                 170                 175     


Leu Arg Thr Thr Leu Lys Val Ile Asp Ile Ser Tyr Gly Arg Gly Thr 
            180                 185                 190         


Gly Asn Thr Ala Leu Val Tyr His Asn Gly Leu Leu Leu Ala Leu Ser 
        195                 200                 205             


Glu Glu Asp Lys Pro Tyr Val Val Lys Val Leu Glu Asp Gly Asp Leu 
    210                 215                 220                 


Gln Thr Leu Gly Ile Leu Asp Tyr Asp Lys Lys Leu Ser His Pro Phe 
225                 230                 235                 240 


Thr Ala His Pro Lys Ile Asp Pro Leu Thr Asp Glu Met Phe Thr Phe 
                245                 250                 255     


Gly Tyr Ser Leu Ser Pro Pro Tyr Leu Thr Tyr Arg Val Ile Ser Lys 
            260                 265                 270         


Asp Gly Val Met Gln Asp Pro Val Gln Ile Ser Ile Thr Ser Pro Thr 
        275                 280                 285             


Ile Met His Asp Phe Ala Ile Thr Glu Asn Tyr Ala Ile Phe Met Asp 
    290                 295                 300                 


Leu Pro Leu Tyr Phe Gln Pro Glu Glu Met Val Lys Gly Lys Phe Val 
305                 310                 315                 320 


Ser Ser Phe His Pro Thr Lys Arg Ala Arg Ile Gly Val Leu Pro Arg 
                325                 330                 335     


Tyr Ala Glu Asp Glu His Pro Ile Arg Trp Phe Asp Leu Pro Ser Cys 
            340                 345                 350         


Phe Met Thr His Asn Ala Asn Ala Trp Glu Glu Asn Asp Glu Val Val 
        355                 360                 365             


Leu Phe Thr Cys Arg Leu Glu Ser Pro Asp Leu Asp Met Leu Ser Gly 
    370                 375                 380                 


Pro Ala Glu Glu Glu Ile Gly Asn Ser Lys Ser Glu Leu Tyr Glu Met 
385                 390                 395                 400 


Arg Phe Asn Leu Lys Thr Gly Ile Thr Ser Gln Lys Gln Leu Ser Val 
                405                 410                 415     


Pro Ser Val Asp Phe Pro Arg Ile Asn Gln Ser Tyr Thr Gly Arg Lys 
            420                 425                 430         


Gln Gln Tyr Val Tyr Cys Thr Leu Gly Asn Thr Lys Ile Lys Gly Ile 
        435                 440                 445             


Val Lys Phe Asp Leu Gln Ile Glu Pro Glu Ala Gly Lys Thr Met Leu 
    450                 455                 460                 


Glu Val Gly Gly Asn Val Gln Gly Ile Phe Glu Leu Gly Pro Arg Arg 
465                 470                 475                 480 


Tyr Gly Ser Glu Ala Ile Phe Val Pro Cys Gln Pro Gly Ile Lys Ser 
                485                 490                 495     


Asp Glu Asp Asp Gly Tyr Leu Ile Phe Phe Val His Asp Glu Asn Asn 
            500                 505                 510         


Gly Lys Ser Glu Val Asn Val Ile Asp Ala Lys Thr Met Ser Ala Glu 
        515                 520                 525             


Pro Val Ala Val Val Gln Leu Pro Ser Arg Val Pro Tyr Gly Phe His 
    530                 535                 540                 


Ala Leu Phe Leu Asn Glu Glu Glu Leu Gln Lys His Gln Ala Glu Thr 
545                 550                 555                 560 


<210>  22
<211>  3222
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide encoding CYP102D1

<400>  22
atgactacac aacctgaaac agacctcaga ccaatacgtt caccaagggg tgtcccactg       60

ttcggccaca ctccacaaat cccttccaca aacccagtcg aatactttgg caaactatct      120

aaacaatttc cagaaggatt gtatgggatg gaaattgctg gtattgaaca agttttcgta      180

tgggaccctg atttggtagc tgaggtgtgc gatgaaacac gattctttaa acaaattgat      240

aaaactccac ttgcacatgt cagagattac gccggcgctg gtttagttac agctcatcaa      300

cacgaagagg aatggggcat ggcgcatcga gtgcttttac cagtatttag ccagagagct      360

atgaaaggat actttggtca aatgctggaa atcgcccaaa acctagttgg aaaatgggaa      420

cgcaaagagg gacaacctgt gaatatcaca gatgattata cacgattgac actagacacc      480

atcgccctgt caggctttgg gtacagattc gactcttttg ctaaagagga tttacatcca      540

ttcctaaacg ccctgctcca agcattggtt gaatcattga gaagatccca ggaattacca      600

gttatgacta agatgagaaa ggccgacgac aaaaagtaca gagagaatat cagactaatg      660

agagacttgg ttgaaaatgt gattaaggaa cgtcgtgaag gcaagggcac aggtgaagat      720

gatctattgg gtcttattct tgaagctact gatcctgaaa ctggaaaggg tttggacgac      780

gacaatgtaa gagatcaggt tgttacgttc ttgattgctg gccacgaaac aacatctggt      840

ttattgagtt ttgcaactta ctctctgatg agaaatccac atatccttgc ccaagcgtac      900

gcagaggtgg atcgtttgct tcctggggac accgttccag attacgatac cattatgcaa      960

atggacgtca ttcctagaat cttggaggaa acgttaagat tgtgggctcc aatcccaatg     1020

atagggaaat ctccattaga agataccgtt atcggtggtt gctatggttt gaaaaagggt     1080

gcaagggtta acattttaga aggaccttta catacacatc ccaaggcgtg ggaaagacca     1140

gaagagttcg acatcaatag atggcttcca gagaatagag tgaatcatca tccacacgct     1200

tacaaaccat ttggtaacgg agtaagagca tgtataggta gacaatttgc attgacagag     1260

gcaagactcg ctttagcctt ggttttacaa aaatttaagt tcgccgatac tgacgactat     1320

aagatggatg ttaaagaggc cttgaccaga aagcctggtg gttttgagct aaatgttaga     1380

gcaagacagg aacatgaaag gaccgtcttt ggcgctgccg atctgcagac agatgatact     1440

caagcccaag cagcagtttc tggagtcggg gttaacctga ctgtagctta cggaagttca     1500

ttgggttctt gcgaagattt ggctcgaaca atagctgata gaggcgaaag atccggtttc     1560

gggacaacat tagttggatt agatgaattg ggtgataatc ttccaactga aggcttgtta     1620

gtggttgtcg catcatcata caacgggaaa gcaccagata acgcacagag atttgacgat     1680

ttactggctg ctggattacc agaaggctct ttatcaaatg tgcgtttcgc cctgttagga     1740

gctggtaaca cacaatgggt cgctacgtac caaggattcc cgaagagaat cgaagccggg     1800

ctgttagcgg ctggtgcaac aagagtaatt gagaggggta tcgctgatgc agccggagat     1860

ttcgatggta tggccactag atggatggat acactgtgga caactcttgc tgaagagtac     1920

gctgcggaca cttcagaaac gaccggacca agatttgagg tacaactatt aaccgaagca     1980

gaagtgaggc cagccatcgt atcagaacaa gcatatccat tgactgtcgt tgctaatgag     2040

gaacttgtct ccgatgcaac tggcctctgg gatttttcga tagaaccacc acgtccagcg     2100

gctaagagta tcacaataga gttgccagac ggtgtgacct acgatactgg aaaccattta     2160

gctgtttttg ccaaaaatga gcctgttctc gtaaataggg cactagccag attgggtgtt     2220

gatcgtgacc aagttctgag attggatcag cccggagggg gcagaaccca tttgccagta     2280

ggtactcctg tcacaacagg cttacttttt acagaatttg tagaattaca ggatgttgct     2340

acaagatccc aaattcagga acttgctgaa cacactcagt gtccttggac aagaccacaa     2400

cttcaagcgt acactgccga tacagctgag gctgaagaga gataccaaaa agagattttg     2460

gggaaaagag tatctgtcct aaacctattg gaaagattcc cagcagttga actaccactt     2520

gcagtattcc ttgagatgat gggcccaatt agacctagat tttactccat atcatctagt     2580

cctttggcca atccaagaca cgtgagattg acagtcggtc tactggaagg cccagcccta     2640

tctggagatg gtcgttacag gggtacttgt agttcctata ttgccggcct cgaaagcggt     2700

gacgtgtttt atggttacgt cagagtacct tctcctactt ttgcacctcc tgcagatcct     2760

gctacgcctt tgttgctcat cggacctggc acaggtatcg ctccattgag aggtttcctt     2820

gaggaaagag cacatcaaca tgctcacggt actcaagtgg gtctatctca agtgttcgtt     2880

ggttgtagac atccagaaca tgactacttt tacagacagg aaatgcaaga ttgggaacaa     2940

gcaggaattg cgcaagttca taccgctttt tcagctgtca ctgggcaccc tgcaagattc     3000

gtccaagatg cgatagtagg cgccgctgac actgtttggc aagctatcca agacggtgca     3060

tacgtgtacg tctgtggcga tggaaggaga atggcccctg cagttagaga agctctcgct     3120

gctatctata gaaagcacac aggttctgat gatgaagctg cccaacaatg gttagcacag     3180

ttagaagctg acgaaagata tcaacaagat gtttttgcat aa                        3222


<210>  23
<211>  1073
<212>  PRT
<213>  Streptomyces avermitilis

<400>  23

Met Thr Thr Gln Pro Glu Thr Asp Leu Arg Pro Ile Arg Ser Pro Arg 
1               5                   10                  15      


Gly Val Pro Leu Phe Gly His Thr Pro Gln Ile Pro Ser Thr Asn Pro 
            20                  25                  30          


Val Glu Tyr Phe Gly Lys Leu Ser Lys Gln Phe Pro Glu Gly Leu Tyr 
        35                  40                  45              


Gly Met Glu Ile Ala Gly Ile Glu Gln Val Phe Val Trp Asp Pro Asp 
    50                  55                  60                  


Leu Val Ala Glu Val Cys Asp Glu Thr Arg Phe Phe Lys Gln Ile Asp 
65                  70                  75                  80  


Lys Thr Pro Leu Ala His Val Arg Asp Tyr Ala Gly Ala Gly Leu Val 
                85                  90                  95      


Thr Ala His Gln His Glu Glu Glu Trp Gly Met Ala His Arg Val Leu 
            100                 105                 110         


Leu Pro Val Phe Ser Gln Arg Ala Met Lys Gly Tyr Phe Gly Gln Met 
        115                 120                 125             


Leu Glu Ile Ala Gln Asn Leu Val Gly Lys Trp Glu Arg Lys Glu Gly 
    130                 135                 140                 


Gln Pro Val Asn Ile Thr Asp Asp Tyr Thr Arg Leu Thr Leu Asp Thr 
145                 150                 155                 160 


Ile Ala Leu Ser Gly Phe Gly Tyr Arg Phe Asp Ser Phe Ala Lys Glu 
                165                 170                 175     


Asp Leu His Pro Phe Leu Asn Ala Leu Leu Gln Ala Leu Val Glu Ser 
            180                 185                 190         


Leu Arg Arg Ser Gln Glu Leu Pro Val Met Thr Lys Met Arg Lys Ala 
        195                 200                 205             


Asp Asp Lys Lys Tyr Arg Glu Asn Ile Arg Leu Met Arg Asp Leu Val 
    210                 215                 220                 


Glu Asn Val Ile Lys Glu Arg Arg Glu Gly Lys Gly Thr Gly Glu Asp 
225                 230                 235                 240 


Asp Leu Leu Gly Leu Ile Leu Glu Ala Thr Asp Pro Glu Thr Gly Lys 
                245                 250                 255     


Gly Leu Asp Asp Asp Asn Val Arg Asp Gln Val Val Thr Phe Leu Ile 
            260                 265                 270         


Ala Gly His Glu Thr Thr Ser Gly Leu Leu Ser Phe Ala Thr Tyr Ser 
        275                 280                 285             


Leu Met Arg Asn Pro His Ile Leu Ala Gln Ala Tyr Ala Glu Val Asp 
    290                 295                 300                 


Arg Leu Leu Pro Gly Asp Thr Val Pro Asp Tyr Asp Thr Ile Met Gln 
305                 310                 315                 320 


Met Asp Val Ile Pro Arg Ile Leu Glu Glu Thr Leu Arg Leu Trp Ala 
                325                 330                 335     


Pro Ile Pro Met Ile Gly Lys Ser Pro Leu Glu Asp Thr Val Ile Gly 
            340                 345                 350         


Gly Cys Tyr Gly Leu Lys Lys Gly Ala Arg Val Asn Ile Leu Glu Gly 
        355                 360                 365             


Pro Leu His Thr His Pro Lys Ala Trp Glu Arg Pro Glu Glu Phe Asp 
    370                 375                 380                 


Ile Asn Arg Trp Leu Pro Glu Asn Arg Val Asn His His Pro His Ala 
385                 390                 395                 400 


Tyr Lys Pro Phe Gly Asn Gly Val Arg Ala Cys Ile Gly Arg Gln Phe 
                405                 410                 415     


Ala Leu Thr Glu Ala Arg Leu Ala Leu Ala Leu Val Leu Gln Lys Phe 
            420                 425                 430         


Lys Phe Ala Asp Thr Asp Asp Tyr Lys Met Asp Val Lys Glu Ala Leu 
        435                 440                 445             


Thr Arg Lys Pro Gly Gly Phe Glu Leu Asn Val Arg Ala Arg Gln Glu 
    450                 455                 460                 


His Glu Arg Thr Val Phe Gly Ala Ala Asp Leu Gln Thr Asp Asp Thr 
465                 470                 475                 480 


Gln Ala Gln Ala Ala Val Ser Gly Val Gly Val Asn Leu Thr Val Ala 
                485                 490                 495     


Tyr Gly Ser Ser Leu Gly Ser Cys Glu Asp Leu Ala Arg Thr Ile Ala 
            500                 505                 510         


Asp Arg Gly Glu Arg Ser Gly Phe Gly Thr Thr Leu Val Gly Leu Asp 
        515                 520                 525             


Glu Leu Gly Asp Asn Leu Pro Thr Glu Gly Leu Leu Val Val Val Ala 
    530                 535                 540                 


Ser Ser Tyr Asn Gly Lys Ala Pro Asp Asn Ala Gln Arg Phe Asp Asp 
545                 550                 555                 560 


Leu Leu Ala Ala Gly Leu Pro Glu Gly Ser Leu Ser Asn Val Arg Phe 
                565                 570                 575     


Ala Leu Leu Gly Ala Gly Asn Thr Gln Trp Val Ala Thr Tyr Gln Gly 
            580                 585                 590         


Phe Pro Lys Arg Ile Glu Ala Gly Leu Leu Ala Ala Gly Ala Thr Arg 
        595                 600                 605             


Val Ile Glu Arg Gly Ile Ala Asp Ala Ala Gly Asp Phe Asp Gly Met 
    610                 615                 620                 


Ala Thr Arg Trp Met Asp Thr Leu Trp Thr Thr Leu Ala Glu Glu Tyr 
625                 630                 635                 640 


Ala Ala Asp Thr Ser Glu Thr Thr Gly Pro Arg Phe Glu Val Gln Leu 
                645                 650                 655     


Leu Thr Glu Ala Glu Val Arg Pro Ala Ile Val Ser Glu Gln Ala Tyr 
            660                 665                 670         


Pro Leu Thr Val Val Ala Asn Glu Glu Leu Val Ser Asp Ala Thr Gly 
        675                 680                 685             


Leu Trp Asp Phe Ser Ile Glu Pro Pro Arg Pro Ala Ala Lys Ser Ile 
    690                 695                 700                 


Thr Ile Glu Leu Pro Asp Gly Val Thr Tyr Asp Thr Gly Asn His Leu 
705                 710                 715                 720 


Ala Val Phe Ala Lys Asn Glu Pro Val Leu Val Asn Arg Ala Leu Ala 
                725                 730                 735     


Arg Leu Gly Val Asp Arg Asp Gln Val Leu Arg Leu Asp Gln Pro Gly 
            740                 745                 750         


Gly Gly Arg Thr His Leu Pro Val Gly Thr Pro Val Thr Thr Gly Leu 
        755                 760                 765             


Leu Phe Thr Glu Phe Val Glu Leu Gln Asp Val Ala Thr Arg Ser Gln 
    770                 775                 780                 


Ile Gln Glu Leu Ala Glu His Thr Gln Cys Pro Trp Thr Arg Pro Gln 
785                 790                 795                 800 


Leu Gln Ala Tyr Thr Ala Asp Thr Ala Glu Ala Glu Glu Arg Tyr Gln 
                805                 810                 815     


Lys Glu Ile Leu Gly Lys Arg Val Ser Val Leu Asn Leu Leu Glu Arg 
            820                 825                 830         


Phe Pro Ala Val Glu Leu Pro Leu Ala Val Phe Leu Glu Met Met Gly 
        835                 840                 845             


Pro Ile Arg Pro Arg Phe Tyr Ser Ile Ser Ser Ser Pro Leu Ala Asn 
    850                 855                 860                 


Pro Arg His Val Arg Leu Thr Val Gly Leu Leu Glu Gly Pro Ala Leu 
865                 870                 875                 880 


Ser Gly Asp Gly Arg Tyr Arg Gly Thr Cys Ser Ser Tyr Ile Ala Gly 
                885                 890                 895     


Leu Glu Ser Gly Asp Val Phe Tyr Gly Tyr Val Arg Val Pro Ser Pro 
            900                 905                 910         


Thr Phe Ala Pro Pro Ala Asp Pro Ala Thr Pro Leu Leu Leu Ile Gly 
        915                 920                 925             


Pro Gly Thr Gly Ile Ala Pro Leu Arg Gly Phe Leu Glu Glu Arg Ala 
    930                 935                 940                 


His Gln His Ala His Gly Thr Gln Val Gly Leu Ser Gln Val Phe Val 
945                 950                 955                 960 


Gly Cys Arg His Pro Glu His Asp Tyr Phe Tyr Arg Gln Glu Met Gln 
                965                 970                 975     


Asp Trp Glu Gln Ala Gly Ile Ala Gln Val His Thr Ala Phe Ser Ala 
            980                 985                 990         


Val Thr Gly His Pro Ala Arg Phe  Val Gln Asp Ala Ile  Val Gly Ala 
        995                 1000                 1005             


Ala Asp  Thr Val Trp Gln Ala  Ile Gln Asp Gly Ala  Tyr Val Tyr 
    1010                 1015                 1020             


Val Cys  Gly Asp Gly Arg Arg  Met Ala Pro Ala Val  Arg Glu Ala 
    1025                 1030                 1035             


Leu Ala  Ala Ile Tyr Arg Lys  His Thr Gly Ser Asp  Asp Glu Ala 
    1040                 1045                 1050             


Ala Gln  Gln Trp Leu Ala Gln  Leu Glu Ala Asp Glu  Arg Tyr Gln 
    1055                 1060                 1065             


Gln Asp  Val Phe Ala 
    1070             


