                         SEQUENCE LISTING

<110>  Julius-Maximilians-Universitt Wrzburg
 
<120>  Peptides derived from RS1 which down-regulate glucose absorption 
       after a glucose rich meal and increase insulin sensitivity

<130>  X1070 PCT S3

<150>  EP 14 16 5597.7
<151>  2014-04-23

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  1851
<212>  DNA
<213>  Homo sapiens

<400>  1
atgagcagcc tgccgaccag cgatggcttt aaccatccgg cgcgcagcag cggccagagc       60

ccggatgtgg gcaacccgat gagcctggcg cgcagcgtga gcgcgagcgt gtgcccgatt      120

aaaccgagcg atagcgatcg cattgaaccg aaagcggtga aagcgctgaa agcgagcgcg      180

gaatttcagc tgaacagcga aaaaaaagaa catctgagcc tgcaggatct gagcgatcat      240

gcgagcagcg cggatcatgc gccgaccgat cagagcccgg cgatgccgat gcagaacagc      300

agcgaagaaa ttaccgtggc gggcaacctg gaaaaaagcg cggaacgcag cacccagggc      360

ctgaaatttc atctgcatac ccgccaggaa gcgagcctga gcgtgaccag cacccgcatg      420

catgaaccgc agatgtttct gggcgaaaaa gattggcatc cggaaaacca gaacctgagc      480

caggtgagcg atccgcagca gcatgaagaa ccgggcaacg aacagtatga agtggcgcag      540

cagaaagcga gccatgatca ggaatatctg tgcaacattg gcgatctgga actgccggaa      600

gaacgccagc agaaccagca taaaattgtg gatctggaag cgaccatgaa aggcaacggc      660

ctgccgcaga acgtggatcc gccgagcgcg aaaaaaagca ttccgagcag cgaatgcagc      720

ggctgcagca acagcgaaac ctttatggaa attgataccg cgcagcagag cctggtgacc      780

ctgctgaaca gcaccggccg ccagaacgcg aacgtgaaaa acattggcgc gctggatctg      840

accctggata acccgctgat ggaagtggaa accagcaaat gcaacccgag cagcgaaatt      900

ctgaacgata gcattagcac ccaggatctg cagccgccgg aaaccaacgt ggaaattccg      960

ggcaccaaca aagaatatgg ccattatagc agcccgagcc tgtgcggcag ctgccagccg     1020

agcgtggaaa gcgcggaaga aagctgcccg agcattaccg cggcgctgaa agaactgcat     1080

gaactgctgg tggtgagcag caaaccggcg agcgaaaaca ccagcgaaga agtgatttgc     1140

cagagcgaaa ccattgcgga aggccagacc agcattaaag atctgagcga acgctggacc     1200

cagaacgaac atctgaccca gaacgaacag tgcccgcagg tgagctttca tcaggcgatt     1260

agcgtgagcg tggaaaccga aaaactgacc ggcaccagca gcgataccgg ccgcgaagcg     1320

gtggaaaacg tgaactttcg cagcctgggc gatggcctga gcaccgataa agaaggcgtg     1380

ccgaaaagcc gcgaaagcat taacaaaaac cgcagcgtga ccgtgaccag cgcgaaaacc     1440

agcaaccagc tgcattgcac cctgggcgtg gaaattagcc cgaaactgct ggcgggcgaa     1500

gaagatgcgc tgaaccagac cagcgaacag accaaaagcc tgagcagcaa ctttattctg     1560

gtgaaagatc tgggccaggg cattcagaac agcgtgaccg atcgcccgga aacccgcgaa     1620

aacgtgtgcc cggatgcgag ccgcccgctg ctggaatatg aaccgccgac cagccatccg     1680

agcagcagcc cggcgattct gccgccgctg atttttccgg cgaccgatat tgatcgcatt     1740

ctgcgcgcgg gctttaccct gcaggaagcg ctgggcgcgc tgcatcgcgt gggcggcaac     1800

gcggatctgg cgctgctggt gctgctggcg aaaaacattg tggtgccgac c              1851


<210>  2
<211>  617
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ser Leu Pro Thr Ser Asp Gly Phe Asn His Pro Ala Arg Ser 
1               5                   10                  15      


Ser Gly Gln Ser Pro Asp Val Gly Asn Pro Met Ser Leu Ala Arg Ser 
            20                  25                  30          


Val Ser Ala Ser Val Cys Pro Ile Lys Pro Ser Asp Ser Asp Arg Ile 
        35                  40                  45              


Glu Pro Lys Ala Val Lys Ala Leu Lys Ala Ser Ala Glu Phe Gln Leu 
    50                  55                  60                  


Asn Ser Glu Lys Lys Glu His Leu Ser Leu Gln Asp Leu Ser Asp His 
65                  70                  75                  80  


Ala Ser Ser Ala Asp His Ala Pro Thr Asp Gln Ser Pro Ala Met Pro 
                85                  90                  95      


Met Gln Asn Ser Ser Glu Glu Ile Thr Val Ala Gly Asn Leu Glu Lys 
            100                 105                 110         


Ser Ala Glu Arg Ser Thr Gln Gly Leu Lys Phe His Leu His Thr Arg 
        115                 120                 125             


Gln Glu Ala Ser Leu Ser Val Thr Ser Thr Arg Met His Glu Pro Gln 
    130                 135                 140                 


Met Phe Leu Gly Glu Lys Asp Trp His Pro Glu Asn Gln Asn Leu Ser 
145                 150                 155                 160 


Gln Val Ser Asp Pro Gln Gln His Glu Glu Pro Gly Asn Glu Gln Tyr 
                165                 170                 175     


Glu Val Ala Gln Gln Lys Ala Ser His Asp Gln Glu Tyr Leu Cys Asn 
            180                 185                 190         


Ile Gly Asp Leu Glu Leu Pro Glu Glu Arg Gln Gln Asn Gln His Lys 
        195                 200                 205             


Ile Val Asp Leu Glu Ala Thr Met Lys Gly Asn Gly Leu Pro Gln Asn 
    210                 215                 220                 


Val Asp Pro Pro Ser Ala Lys Lys Ser Ile Pro Ser Ser Glu Cys Ser 
225                 230                 235                 240 


Gly Cys Ser Asn Ser Glu Thr Phe Met Glu Ile Asp Thr Ala Gln Gln 
                245                 250                 255     


Ser Leu Val Thr Leu Leu Asn Ser Thr Gly Arg Gln Asn Ala Asn Val 
            260                 265                 270         


Lys Asn Ile Gly Ala Leu Asp Leu Thr Leu Asp Asn Pro Leu Met Glu 
        275                 280                 285             


Val Glu Thr Ser Lys Cys Asn Pro Ser Ser Glu Ile Leu Asn Asp Ser 
    290                 295                 300                 


Ile Ser Thr Gln Asp Leu Gln Pro Pro Glu Thr Asn Val Glu Ile Pro 
305                 310                 315                 320 


Gly Thr Asn Lys Glu Tyr Gly His Tyr Ser Ser Pro Ser Leu Cys Gly 
                325                 330                 335     


Ser Cys Gln Pro Ser Val Glu Ser Ala Glu Glu Ser Cys Pro Ser Ile 
            340                 345                 350         


Thr Ala Ala Leu Lys Glu Leu His Glu Leu Leu Val Val Ser Ser Lys 
        355                 360                 365             


Pro Ala Ser Glu Asn Thr Ser Glu Glu Val Ile Cys Gln Ser Glu Thr 
    370                 375                 380                 


Ile Ala Glu Gly Gln Thr Ser Ile Lys Asp Leu Ser Glu Arg Trp Thr 
385                 390                 395                 400 


Gln Asn Glu His Leu Thr Gln Asn Glu Gln Cys Pro Gln Val Ser Phe 
                405                 410                 415     


His Gln Ala Ile Ser Val Ser Val Glu Thr Glu Lys Leu Thr Gly Thr 
            420                 425                 430         


Ser Ser Asp Thr Gly Arg Glu Ala Val Glu Asn Val Asn Phe Arg Ser 
        435                 440                 445             


Leu Gly Asp Gly Leu Ser Thr Asp Lys Glu Gly Val Pro Lys Ser Arg 
    450                 455                 460                 


Glu Ser Ile Asn Lys Asn Arg Ser Val Thr Val Thr Ser Ala Lys Thr 
465                 470                 475                 480 


Ser Asn Gln Leu His Cys Thr Leu Gly Val Glu Ile Ser Pro Lys Leu 
                485                 490                 495     


Leu Ala Gly Glu Glu Asp Ala Leu Asn Gln Thr Ser Glu Gln Thr Lys 
            500                 505                 510         


Ser Leu Ser Ser Asn Phe Ile Leu Val Lys Asp Leu Gly Gln Gly Ile 
        515                 520                 525             


Gln Asn Ser Val Thr Asp Arg Pro Glu Thr Arg Glu Asn Val Cys Pro 
    530                 535                 540                 


Asp Ala Ser Arg Pro Leu Leu Glu Tyr Glu Pro Pro Thr Ser His Pro 
545                 550                 555                 560 


Ser Ser Ser Pro Ala Ile Leu Pro Pro Leu Ile Phe Pro Ala Thr Asp 
                565                 570                 575     


Ile Asp Arg Ile Leu Arg Ala Gly Phe Thr Leu Gln Glu Ala Leu Gly 
            580                 585                 590         


Ala Leu His Arg Val Gly Gly Asn Ala Asp Leu Ala Leu Leu Val Leu 
        595                 600                 605             


Leu Ala Lys Asn Ile Val Val Pro Thr 
    610                 615         


<210>  3
<211>  1749
<212>  DNA
<213>  Mus musculus

<400>  3
atgtcatcat tgccgacttc agatgggttt gaccatccag ctccttcagg gcagagtcct       60

gaggttggta gcccgacgag tctcgctcgc tctgtttctg cttccgtctg cgccatcaag      120

cccggtgacc ccaatagcat tgaatctcta gctatggagg ctacgaaggc ttcagctgaa      180

ttccagacaa actctaagaa aacagaccct cctcctctgc aggttcttcc tgaccttgct      240

tcctcagcag agcagagtct agccatgcct ttccataagt catcaaaaga agccgttgtt      300

gcaggtaatc tggagaaatc tgttgagaaa ggaacccagg gcctcagagt gtatctccac      360

acaagacagg acgctagttt aactctcaca actactggga tgcgggagcc acagatattt      420

gcggaggaaa agagttggca tccagaaaat cagaccccaa gtcccgtgaa cggccttcag      480

cagcacagag aaacagggag tgtacagcga gaggctggac agcagagtgt tccacaggac      540

cagggctgtc tttgtgacgc agaagacctt gagcttcatg aagaagttgt cagtttggaa      600

gctctgagga aaggtgagct acaaagacac gctcatcttc ccagtgcaga gaagggtctt      660

ccagcttcag gactctgtag ctgtccatgc tcagaagccc tgatggaagt agatacagct      720

gaacagtctc tggttgctat gtgcagctca acaggcaggc aggatgccgt catcaagagc      780

cctagtgtag cacatctcgc ttcagataat cccactatgg aagtggagac attacagtct      840

aacccgtcct gtgagcctgt ggaacattcc atcttgactc gggaattgca gctcccagaa      900

gataatgttg acatgtctac aatggataac aaagatgaca attcctcttc ccttctaagt      960

ggccacggtc agccctctgt ggaatcagca gaagaatttt gttcatctgt cacagtggcc     1020

ttgaaagaac tccatgagct tttggtcatt agctgtaagc cagcttcaga agagtcacct     1080

gagcatgtta cctgtcagtc agagatagga gctgagagcc aaccaagtgt ttcagacctt     1140

tcaggaagaa gggtccaaag tgtgcatttg acccctagtg accagtactc acaaggctcc     1200

tgtcaccagg ccacctctga atcaggaaag acagaaatcg taggaactgc cccttgtgct     1260

gcggtagaag atgaagcatc cactagcttt gaaggtctgg gtgatggctt gtcacctgac     1320

cgagaagatg tccgcagatc aacagagtca gccaggaaga gctgttctgt cgccataacc     1380

tcggctaaac tgtctgagca gttgccctgc acctcagggg tagaaatagc acctgaactt     1440

gcagcaagtg agggtgccca cagtcagcct tcagagcatg tgcataatcc aggcccagac     1500

aggccggaga ccagcagtgt ctgccctgga gctgggttgc cccgtagtgg attggaccaa     1560

cctcccacac agtccttgtc caccccctcc gttcttccac cgttcatctt tcctgctgca     1620

gatgttgaca ggattcttgg tgccggcttc actctgcagg aagcgctcgg ggctctgcat     1680

cgagttggtg ggaatgcaga ccttgccctt cttgttttgt tagcaaagaa cattgtagtc     1740

ccaacataa                                                             1749


<210>  4
<211>  565
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ser Ser Leu Pro Thr Ser Asp Gly Phe Asp His Pro Ala Pro Ser 
1               5                   10                  15      


Gly Gln Ser Pro Glu Val Gly Ser Pro Thr Ser Leu Ala Arg Ser Val 
            20                  25                  30          


Ser Ala Ser Val Cys Ala Ile Lys Pro Gly Asp Pro Asn Ser Ile Glu 
        35                  40                  45              


Ser Leu Ala Met Glu Ala Thr Lys Ala Ser Ala Glu Phe Gln Thr Asn 
    50                  55                  60                  


Ser Lys Lys Thr Asp Pro Pro Pro Leu Gln Val Leu Pro Asp Leu Ala 
65                  70                  75                  80  


Ser Ser Ala Glu Gln Ser Leu Ala Met Pro Phe His Lys Ser Ser Lys 
                85                  90                  95      


Glu Ala Val Val Ala Gly Asn Leu Glu Lys Ser Val Glu Lys Gly Thr 
            100                 105                 110         


Gln Gly Leu Arg Val Tyr Leu His Thr Arg Gln Asp Ala Ser Leu Thr 
        115                 120                 125             


Leu Thr Thr Thr Gly Met Arg Glu Pro Gln Ile Phe Ala Glu Glu Lys 
    130                 135                 140                 


Ser Trp His Pro Glu Asn Gln Thr Pro Ser Pro Val Asn Gly Leu Gln 
145                 150                 155                 160 


His Arg Glu Thr Gly Ser Val Gln Arg Glu Ala Gly Gln Gln Ser Val 
                165                 170                 175     


Pro Gln Asp Gln Gly Cys Leu Cys Asp Ala Glu Asp Leu Glu Leu His 
            180                 185                 190         


Glu Glu Val Val Ser Leu Glu Ala Leu Arg Lys Gly Glu Leu Gln Arg 
        195                 200                 205             


His Ala His Leu Pro Ser Ala Glu Lys Gly Leu Pro Ala Ser Gly Leu 
    210                 215                 220                 


Cys Ser Cys Pro Cys Ser Glu Ala Leu Met Glu Val Asp Thr Ala Glu 
225                 230                 235                 240 


Gln Ser Leu Val Ala Met Cys Ser Ser Thr Gly Arg Gln Asp Ala Val 
                245                 250                 255     


Ile Lys Ser Pro Ser Val Ala His Leu Ala Ser Asp Asn Pro Thr Met 
            260                 265                 270         


Glu Val Glu Thr Leu Gln Ser Asn Pro Ser Cys Glu Pro Val Glu His 
        275                 280                 285             


Ser Ile Leu Thr Arg Glu Leu Gln Leu Pro Glu Asp Asn Val Asp Met 
    290                 295                 300                 


Ser Thr Met Asp Asn Lys Asp Asp Asn Ser Ser Ser Leu Leu Ser Gly 
305                 310                 315                 320 


His Gly Gln Pro Ser Val Glu Ser Ala Glu Glu Phe Cys Ser Ser Val 
                325                 330                 335     


Thr Val Ala Leu Lys Glu Leu His Glu Leu Leu Val Ile Ser Cys Lys 
            340                 345                 350         


Pro Ala Ser Glu Glu Ser Pro Glu His Val Thr Cys Gln Ser Glu Ile 
        355                 360                 365             


Gly Ala Glu Ser Gln Pro Ser Val Ser Asp Leu Ser Gly Arg Arg Val 
    370                 375                 380                 


Gln Ser Val His Leu Thr Pro Ser Asp Gln Tyr Ser Gln Gly Ser Cys 
385                 390                 395                 400 


His Gln Ala Thr Ser Glu Ser Gly Lys Thr Glu Ile Val Gly Thr Ala 
                405                 410                 415     


Pro Cys Ala Ala Val Glu Asp Glu Ala Ser Thr Ser Phe Glu Gly Leu 
            420                 425                 430         


Gly Asp Gly Leu Ser Pro Asp Arg Glu Asp Val Arg Arg Ser Thr Glu 
        435                 440                 445             


Ser Ala Arg Lys Ser Cys Ser Val Ala Ile Thr Ser Ala Lys Leu Ser 
    450                 455                 460                 


Glu Gln Leu Pro Cys Thr Ser Gly Val Glu Ile Ala Pro Glu Leu Ala 
465                 470                 475                 480 


Ala Ser Glu Gly Ala His Ser Gln Pro Ser Glu His Val His Asn Pro 
                485                 490                 495     


Gly Pro Asp Arg Pro Glu Thr Ser Ser Val Cys Pro Gly Ala Gly Leu 
            500                 505                 510         


Pro Arg Ser Gly Leu Asp Gln Pro Pro Thr Gln Ser Leu Ser Thr Pro 
        515                 520                 525             


Ser Val Leu Pro Pro Phe Ile Phe Pro Ala Ala Asp Val Asp Arg Ile 
    530                 535                 540                 


Leu Gly Ala Gly Phe Thr Leu Gln Glu Ala Leu Gly Ala Leu His Arg 
545                 550                 555                 560 


Val Gly Gly Asn Ala 
                565 


<210>  5
<211>  249
<212>  DNA
<213>  Homo sapiens

<400>  5
tcttcaggac agagtcctga tgttggtaat cctatgagtc ttgctcgctc tgtctctgct       60

tcagtctgcc ctatcaagcc cagtgactca gatcgcattg aacctaaagc tgtgaaggct      120

ttgaaggctt cagctgaatt ccagctaaac tctgaaaaga aagaacatct ttctttacaa      180

gatctttctg atcatgcttc ctcagcagac catgctccaa cagaccagag tccagctatg      240

cctatgcag                                                              249


<210>  6
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Ser Gly Gln Ser Pro Asp Val Gly Asn Pro Met Ser Leu Ala Arg 
1               5                   10                  15      


Ser Val Ser Ala Ser Val Cys Pro Ile Lys Pro Ser Asp Ser Asp Arg 
            20                  25                  30          


Ile Glu Pro Lys Ala Val Lys Ala Leu Lys Ala Ser Ala Glu Phe Gln 
        35                  40                  45              


Leu Asn Ser Glu Lys Lys Glu His Leu Ser Leu Gln Asp Leu Ser Asp 
    50                  55                  60                  


His Ala Ser Ser Ala Asp His Ala Pro Thr Asp Gln Ser Pro Ala Met 
65                  70                  75                  80  


Pro Met Gln 
            


<210>  7
<211>  234
<212>  DNA
<213>  Mus musculus

<400>  7
ccttcagggc agagtcctga ggttggtagc ccgacgagtc tcgctcgctc tgtttctgct       60

tccgtctgcg ccatcaagcc cggtgacccc aatagcattg aatctctagc tatggaggct      120

acgaaggctt cagctgaatt ccagacaaac tctaagaaaa cagaccctcc tcctctgcag      180

gttcttcctg accttgcttc ctcagcagag cagagtctag ccatgccttt ccat            234


<210>  8
<211>  78
<212>  PRT
<213>  Mus musculus

<400>  8

Pro Ser Gly Gln Ser Pro Glu Val Gly Ser Pro Thr Ser Leu Ala Arg 
1               5                   10                  15      


Ser Val Ser Ala Ser Val Cys Ala Ile Lys Pro Gly Asp Pro Asn Ser 
            20                  25                  30          


Ile Glu Ser Leu Ala Met Glu Ala Thr Lys Ala Ser Ala Glu Phe Gln 
        35                  40                  45              


Thr Asn Ser Lys Lys Thr Asp Pro Pro Pro Leu Gln Val Leu Pro Asp 
    50                  55                  60                  


Leu Ala Ser Ser Ala Glu Gln Ser Leu Ala Met Pro Phe His 
65                  70                  75              


<210>  9
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  source
<223>  /note="description of artificial sequence: hRS1-Reg(S20E)"

<400>  9

Ser Ser Gly Gln Glu Pro Asp Val Gly Asn Pro Met Ser Leu Ala Arg 
1               5                   10                  15      


Ser Val Ser Ala Ser Val Cys Pro Ile Lys Pro Ser Asp Ser Asp Arg 
            20                  25                  30          


Ile Glu Pro Lys Ala Val Lys Ala Leu Lys Ala Ser Ala Glu Phe Gln 
        35                  40                  45              


Leu Asn Ser Glu Lys Lys Glu His Leu Ser Leu Gln Asp Leu Ser Asp 
    50                  55                  60                  


His Ala Ser Ser Ala Asp His Ala Pro Thr Asp Gln Ser Pro Ala Met 
65                  70                  75                  80  


Pro Met Gln 
            


<210>  10
<211>  78
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  source
<223>  /note="description of artificial sequence: mRS1-Reg(S19E)"

<400>  10

Pro Ser Gly Gln Glu Pro Glu Val Gly Ser Pro Thr Ser Leu Ala Arg 
1               5                   10                  15      


Ser Val Ser Ala Ser Val Cys Ala Ile Lys Pro Gly Asp Pro Asn Ser 
            20                  25                  30          


Ile Glu Ser Leu Ala Met Glu Ala Thr Lys Ala Ser Ala Glu Phe Gln 
        35                  40                  45              


Thr Asn Ser Lys Lys Thr Asp Pro Pro Pro Leu Gln Val Leu Pro Asp 
    50                  55                  60                  


Leu Ala Ser Ser Ala Glu Gln Ser Leu Ala Met Pro Phe His 
65                  70                  75              


<210>  11
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Val Gly Asn Pro Met Ser Leu Ala Arg Ser Val Ser Ala Ser Val 
1               5                   10                  15      


Cys Pro Ile Lys Pro Ser Asp Ser Asp Arg Ile Glu Pro Lys Ala Val 
            20                  25                  30          


Lys Ala Leu Lys Ala Ser Ala Glu Phe Gln Leu Asn Ser Glu Lys Lys 
        35                  40                  45              


Glu His Leu Ser Leu Gln Asp Leu Ser Asp His Ala Ser Ser Ala Asp 
    50                  55                  60                  


His Ala Pro Thr Asp Gln Ser Pro Ala Met Pro Met Gln 
65                  70                  75          


<210>  12
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Val Gly Asn Pro Met Ser Leu Ala Arg Ser Val Ser Ala Ser Val 
1               5                   10                  15      


Cys Pro Ile Lys Pro 
            20      


<210>  13
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  13

Lys Ala Val Lys Ala Leu Lys Ala Ser Ala Glu Phe Gln Leu Asn Ser 
1               5                   10                  15      


Glu Lys Lys Glu His Leu Ser Leu Gln Asp Leu Ser Asp His Ala Ser 
            20                  25                  30          


Ser Ala Asp His Ala Pro Thr Asp 
        35                  40  


<210>  14
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  14

Ala Met Pro Met Gln 
1               5   


<210>  15
<211>  72
<212>  PRT
<213>  Mus musculus

<400>  15

Glu Val Gly Ser Pro Thr Ser Leu Ala Arg Ser Val Ser Ala Ser Val 
1               5                   10                  15      


Cys Ala Ile Lys Pro Gly Asp Pro Asn Ser Ile Glu Ser Leu Ala Met 
            20                  25                  30          


Glu Ala Thr Lys Ala Ser Ala Glu Phe Gln Thr Asn Ser Lys Lys Thr 
        35                  40                  45              


Asp Pro Pro Pro Leu Gln Val Leu Pro Asp Leu Ala Ser Ser Ala Glu 
    50                  55                  60                  


Gln Ser Leu Ala Met Pro Phe His 
65                  70          


<210>  16
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  source
<223>  /note="description of artificial sequence: RS1-Reg-derived polypeptide"


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Xaa Gln Glu Pro Xaa Ser Asp Ser Asp Arg Ile Glu Pro Xaa Gln Ser 
1               5                   10                  15      


Pro Xaa 
        


<210>  17
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  17

Ser Asp Ser Asp Arg Ile Glu Pro 
1               5               


<210>  18
<211>  77
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  source
<223>  /note="description of artificial sequence: Part of a RS1-Reg-derived polypeptide (xm)"


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (24)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (29)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (32)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (48)..(52)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (64)..(64)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (76)..(77)
<223>  Xaa can be any naturally occurring amino acid

<400>  18

Xaa Val Gly Xaa Pro Xaa Ser Leu Ala Arg Ser Val Ser Ala Ser Xaa 
1               5                   10                  15      


Cys Xaa Ile Lys Pro Xaa Asp Xaa Xaa Xaa Ile Glu Xaa Xaa Ala Xaa 
            20                  25                  30          


Xaa Ala Xaa Lys Ala Ser Ala Glu Phe Gln Xaa Asn Ser Xaa Lys Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Leu Gln Xaa Leu Xaa Asp Xaa Ala Ser Ser Ala Xaa 
    50                  55                  60                  


His Ala Pro Thr Asp Gln Ser Xaa Ala Met Pro Xaa Xaa 
65                  70                  75          


<210>  19
<211>  72
<212>  PRT
<213>  Mus musculus

<400>  19

Glu Val Gly Ser Pro Thr Ser Leu Ala Arg Ser Val Ser Ala Ser Val 
1               5                   10                  15      


Cys Ala Ile Lys Pro Gly Asp Pro Asn Ser Ile Glu Ser Leu Ala Met 
            20                  25                  30          


Glu Ala Thr Lys Ala Ser Ala Glu Phe Gln Thr Asn Ser Lys Lys Thr 
        35                  40                  45              


Asp Pro Pro Pro Leu Gln Val Leu Pro Asp Leu Ala Ser Ser Ala Glu 
    50                  55                  60                  


Gln Ser Leu Ala Met Pro Phe His 
65                  70          


<210>  20
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  20

Asp Val Gly Asn Pro Met Ser Leu Ala Arg Ser Val Ser Ala Ser Val 
1               5                   10                  15      


Cys Pro Ile Lys Pro Ser Asp Ser Asp Arg Ile Glu Pro Lys Ala Val 
            20                  25                  30          


Lys Ala Leu Lys Ala Ser Ala Glu Phe Gln Leu Asn Ser Glu Lys Lys 
        35                  40                  45              


Glu His Leu Ser Leu Gln Asp Leu Ser Asp His Ala Ser Ser Ala Asp 
    50                  55                  60                  


His Ala Pro Thr Asp Gln Ser Pro Ala Met Pro Met Gln 
65                  70                  75          


<210>  21
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  source
<223>  /note="description of artificial sequence: Part of a RS1-Reg-derived polypeptide (xl)"


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

Xaa Val Gly Xaa Pro Xaa Ser Leu Ala Arg Ser Val Ser Ala Ser Xaa 
1               5                   10                  15      


Cys Xaa Ile Lys Pro 
            20      


<210>  22
<211>  21
<212>  PRT
<213>  Mus musculus

<400>  22

Glu Val Gly Ser Pro Thr Ser Leu Ala Arg Ser Val Ser Ala Ser Val 
1               5                   10                  15      


Cys Ala Ile Lys Pro 
            20      


<210>  23
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  23

Asp Val Gly Asn Pro Met Ser Leu Ala Arg Ser Val Ser Ala Ser Val 
1               5                   10                  15      


Cys Pro Ile Lys Pro 
            20      


<210>  24
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  source
<223>  /note="description of artificial sequence: Part of a RS1-Reg-derived polypeptide (xm)"


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(23)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<400>  24

Xaa Ala Xaa Xaa Ala Xaa Lys Ala Ser Ala Glu Phe Gln Xaa Asn Ser 
1               5                   10                  15      


Xaa Lys Xaa Xaa Xaa Xaa Xaa Leu Gln Xaa Leu Xaa Asp Xaa Ala Ser 
            20                  25                  30          


Ser Ala Xaa His Ala Pro Thr Asp 
        35                  40  


<210>  25
<211>  35
<212>  PRT
<213>  Mus musculus

<400>  25

Leu Ala Met Glu Ala Thr Lys Ala Ser Ala Glu Phe Gln Thr Asn Ser 
1               5                   10                  15      


Lys Lys Thr Asp Pro Pro Pro Leu Gln Val Leu Pro Asp Leu Ala Ser 
            20                  25                  30          


Ser Ala Glu 
        35  


<210>  26
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  26

Lys Ala Val Lys Ala Leu Lys Ala Ser Ala Glu Phe Gln Leu Asn Ser 
1               5                   10                  15      


Glu Lys Lys Glu His Leu Ser Leu Gln Asp Leu Ser Asp His Ala Ser 
            20                  25                  30          


Ser Ala Asp His Ala Pro Thr Asp 
        35                  40  


<210>  27
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  source
<223>  /note="description of artificial sequence: Part of a RS1-Reg-derived polypeptide (xj)"


<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  27

Ala Met Pro Xaa Xaa 
1               5   


<210>  28
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  28

Ala Met Pro Phe His 
1               5   


<210>  29
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  29

Ala Met Pro Met Gln 
1               5   


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  source
<223>  /note="description of artificial sequence: QEP multimer"

<400>  30

Gln Glu Pro Gln Glu Pro 
1               5       


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  source
<223>  /note="description of artificial sequence: QEP multimer"

<400>  31

Gln Glu Pro Gln Glu Pro Gln Glu Pro 
1               5                   


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  source
<223>  /note="description of artificial sequence: QEP multimer with linker"


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  32

Gln Glu Pro Xaa Gln Glu Pro 
1               5           


<210>  33
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  source
<223>  /note="description of artificial sequence: QEP multimer with linker"


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  33

Gln Glu Pro Xaa Gln Glu Pro Xaa Gln Glu Pro 
1               5                   10      


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<221>  source
<223>  /note="description of artificial sequence: TAT peptide"

<400>  34

Cys Gly Arg Leu Leu Arg Arg Gln Arg Arg Arg 
1               5                   10      


