                         SEQUENCE LISTING

<110>  Statens Serum Institut
 
<120>  New M.tuberculosis vaccines

<130>  15074

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  460
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  1

Met Thr Gln Ser Gln Thr Val Thr Val Asp Gln Gln Glu Ile Leu Asn 
1               5                   10                  15      


Arg Ala Asn Glu Val Glu Ala Pro Met Ala Asp Pro Pro Thr Asp Val 
            20                  25                  30          


Pro Ile Thr Pro Cys Glu Leu Thr Ala Ala Lys Asn Ala Ala Gln Gln 
        35                  40                  45              


Leu Val Leu Ser Ala Asp Asn Met Arg Glu Tyr Leu Ala Ala Gly Ala 
    50                  55                  60                  


Lys Glu Arg Gln Arg Leu Ala Thr Ser Leu Arg Asn Ala Ala Lys Ala 
65                  70                  75                  80  


Tyr Gly Glu Val Asp Glu Glu Ala Ala Thr Ala Leu Asp Asn Asp Gly 
                85                  90                  95      


Glu Gly Thr Val Gln Ala Glu Ser Ala Gly Ala Val Gly Gly Asp Ser 
            100                 105                 110         


Ser Ala Glu Leu Thr Asp Thr Pro Arg Val Ala Thr Ala Gly Glu Pro 
        115                 120                 125             


Asn Phe Met Asp Leu Lys Glu Ala Ala Arg Lys Leu Glu Thr Gly Asp 
    130                 135                 140                 


Gln Gly Ala Ser Leu Ala His Phe Ala Asp Gly Trp Asn Thr Phe Asn 
145                 150                 155                 160 


Leu Thr Leu Gln Gly Asp Val Lys Arg Phe Arg Gly Phe Asp Asn Trp 
                165                 170                 175     


Glu Gly Asp Ala Ala Thr Ala Cys Glu Ala Ser Leu Asp Gln Gln Arg 
            180                 185                 190         


Gln Trp Ile Leu His Met Ala Lys Leu Ser Ala Ala Met Ala Lys Gln 
        195                 200                 205             


Ala Gln Tyr Val Ala Gln Leu His Val Trp Ala Arg Arg Glu His Pro 
    210                 215                 220                 


Thr Tyr Glu Asp Ile Val Gly Leu Glu Arg Leu Tyr Ala Glu Asn Pro 
225                 230                 235                 240 


Ser Ala Arg Asp Gln Ile Leu Pro Val Tyr Ala Glu Tyr Gln Gln Arg 
                245                 250                 255     


Ser Glu Lys Val Leu Thr Glu Tyr Asn Asn Lys Ala Ala Leu Glu Pro 
            260                 265                 270         


Val Asn Pro Pro Lys Pro Pro Pro Ala Ile Lys Ile Asp Pro Pro Pro 
        275                 280                 285             


Pro Pro Gln Glu Gln Gly Leu Ile Pro Gly Phe Leu Met Pro Pro Ser 
    290                 295                 300                 


Asp Gly Ser Gly Val Thr Pro Gly Thr Gly Met Pro Ala Ala Pro Met 
305                 310                 315                 320 


Val Pro Pro Thr Gly Ser Pro Gly Gly Gly Leu Pro Ala Asp Thr Ala 
                325                 330                 335     


Ala Gln Leu Thr Ser Ala Gly Arg Glu Ala Ala Ala Leu Ser Gly Asp 
            340                 345                 350         


Val Ala Val Lys Ala Ala Ser Leu Gly Gly Gly Gly Gly Gly Gly Val 
        355                 360                 365             


Pro Ser Ala Pro Leu Gly Ser Ala Ile Gly Gly Ala Glu Ser Val Arg 
    370                 375                 380                 


Pro Ala Gly Ala Gly Asp Ile Ala Gly Leu Gly Gln Gly Arg Ala Gly 
385                 390                 395                 400 


Gly Gly Ala Ala Leu Gly Gly Gly Gly Met Gly Met Pro Met Gly Ala 
                405                 410                 415     


Ala His Gln Gly Gln Gly Gly Ala Lys Ser Lys Gly Ser Gln Gln Glu 
            420                 425                 430         


Asp Glu Ala Leu Tyr Thr Glu Asp Arg Ala Trp Thr Glu Ala Val Ile 
        435                 440                 445             


Gly Asn Arg Arg Arg Gln Asp Ser Lys Glu Ser Lys 
    450                 455                 460 


<210>  2
<211>  95
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  2

Met Thr Glu Gln Gln Trp Asn Phe Ala Gly Ile Glu Ala Ala Ala Ser 
1               5                   10                  15      


Ala Ile Gln Gly Asn Val Thr Ser Ile His Ser Leu Leu Asp Glu Gly 
            20                  25                  30          


Lys Gln Ser Leu Thr Lys Leu Ala Ala Ala Trp Gly Gly Ser Gly Ser 
        35                  40                  45              


Glu Ala Tyr Gln Gly Val Gln Gln Lys Trp Asp Ala Thr Ala Thr Glu 
    50                  55                  60                  


Leu Asn Asn Ala Leu Gln Asn Leu Ala Arg Thr Ile Ser Glu Ala Gly 
65                  70                  75                  80  


Gln Ala Met Ala Ser Thr Glu Gly Asn Val Thr Gly Met Phe Ala 
                85                  90                  95  


<210>  3
<211>  184
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  3

Met Asp Leu Pro Gly Asn Asp Phe Asp Ser Asn Asp Phe Asp Ala Val 
1               5                   10                  15      


Asp Leu Trp Gly Ala Asp Gly Ala Glu Gly Trp Thr Ala Asp Pro Ile 
            20                  25                  30          


Ile Gly Val Gly Ser Ala Ala Thr Pro Asp Thr Gly Pro Asp Leu Asp 
        35                  40                  45              


Asn Ala His Gly Gln Ala Glu Thr Asp Thr Glu Gln Glu Ile Ala Leu 
    50                  55                  60                  


Phe Thr Val Thr Asn Pro Pro Arg Thr Val Ser Val Ser Thr Leu Met 
65                  70                  75                  80  


Asp Gly Arg Ile Asp His Val Glu Leu Ser Ala Arg Val Ala Trp Met 
                85                  90                  95      


Ser Glu Ser Gln Leu Ala Ser Glu Ile Leu Val Ile Ala Asp Leu Ala 
            100                 105                 110         


Arg Gln Lys Ala Gln Ser Ala Gln Tyr Ala Phe Ile Leu Asp Arg Met 
        115                 120                 125             


Ser Gln Gln Val Asp Ala Asp Glu His Arg Val Ala Leu Leu Arg Lys 
    130                 135                 140                 


Thr Val Gly Glu Thr Trp Gly Leu Pro Ser Pro Glu Glu Ala Ala Ala 
145                 150                 155                 160 


Ala Glu Ala Glu Val Phe Ala Thr Arg Tyr Ser Asp Asp Cys Pro Ala 
                165                 170                 175     


Pro Asp Asp Glu Ser Asp Pro Trp 
            180                 


<210>  4
<211>  103
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  4

Met Thr Glu Asn Leu Thr Val Gln Pro Glu Arg Leu Gly Val Leu Ala 
1               5                   10                  15      


Ser His His Asp Asn Ala Ala Val Asp Ala Ser Ser Gly Val Glu Ala 
            20                  25                  30          


Ala Ala Gly Leu Gly Glu Ser Val Ala Ile Thr His Gly Pro Tyr Cys 
        35                  40                  45              


Ser Gln Phe Asn Asp Thr Leu Asn Val Tyr Leu Thr Ala His Asn Ala 
    50                  55                  60                  


Leu Gly Ser Ser Leu His Thr Ala Gly Val Asp Leu Ala Lys Ser Leu 
65                  70                  75                  80  


Arg Ile Ala Ala Lys Ile Tyr Ser Glu Ala Asp Glu Ala Trp Arg Lys 
                85                  90                  95      


Ala Ile Asp Gly Leu Phe Thr 
            100             


<210>  5
<211>  392
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  5

Met Ser Arg Ala Phe Ile Ile Asp Pro Thr Ile Ser Ala Ile Asp Gly 
1               5                   10                  15      


Leu Tyr Asp Leu Leu Gly Ile Gly Ile Pro Asn Gln Gly Gly Ile Leu 
            20                  25                  30          


Tyr Ser Ser Leu Glu Tyr Phe Glu Lys Ala Leu Glu Glu Leu Ala Ala 
        35                  40                  45              


Ala Phe Pro Gly Asp Gly Trp Leu Gly Ser Ala Ala Asp Lys Tyr Ala 
    50                  55                  60                  


Gly Lys Asn Arg Asn His Val Asn Phe Phe Gln Glu Leu Ala Asp Leu 
65                  70                  75                  80  


Asp Arg Gln Leu Ile Ser Leu Ile His Asp Gln Ala Asn Ala Val Gln 
                85                  90                  95      


Thr Thr Arg Asp Ile Leu Glu Gly Ala Lys Lys Gly Leu Glu Phe Val 
            100                 105                 110         


Arg Pro Val Ala Val Asp Leu Thr Tyr Ile Pro Val Val Gly His Ala 
        115                 120                 125             


Leu Ser Ala Ala Phe Gln Ala Pro Phe Cys Ala Gly Ala Met Ala Val 
    130                 135                 140                 


Val Gly Gly Ala Leu Ala Tyr Leu Val Val Lys Thr Leu Ile Asn Ala 
145                 150                 155                 160 


Thr Gln Leu Leu Lys Leu Leu Ala Lys Leu Ala Glu Leu Val Ala Ala 
                165                 170                 175     


Ala Ile Ala Asp Ile Ile Ser Asp Val Ala Asp Ile Ile Lys Gly Thr 
            180                 185                 190         


Leu Gly Glu Val Trp Glu Phe Ile Thr Asn Ala Leu Asn Gly Leu Lys 
        195                 200                 205             


Glu Leu Trp Asp Lys Leu Thr Gly Trp Val Thr Gly Leu Phe Ser Arg 
    210                 215                 220                 


Gly Trp Ser Asn Leu Glu Ser Phe Phe Ala Gly Val Pro Gly Leu Thr 
225                 230                 235                 240 


Gly Ala Thr Ser Gly Leu Ser Gln Val Thr Gly Leu Phe Gly Ala Ala 
                245                 250                 255     


Gly Leu Ser Ala Ser Ser Gly Leu Ala His Ala Asp Ser Leu Ala Ser 
            260                 265                 270         


Ser Ala Ser Leu Pro Ala Leu Ala Gly Ile Gly Gly Gly Ser Gly Phe 
        275                 280                 285             


Gly Gly Leu Pro Ser Leu Ala Gln Val His Ala Ala Ser Thr Arg Gln 
    290                 295                 300                 


Ala Leu Arg Pro Arg Ala Asp Gly Pro Val Gly Ala Ala Ala Glu Gln 
305                 310                 315                 320 


Val Gly Gly Gln Ser Gln Leu Val Ser Ala Gln Gly Ser Gln Gly Met 
                325                 330                 335     


Gly Gly Pro Val Gly Met Gly Gly Met His Pro Ser Ser Gly Ala Ser 
            340                 345                 350         


Lys Gly Thr Thr Thr Lys Lys Tyr Ser Glu Gly Ala Ala Ala Gly Thr 
        355                 360                 365             


Glu Asp Ala Glu Arg Ala Pro Val Glu Ala Asp Ala Gly Gly Gly Gln 
    370                 375                 380                 


Lys Val Leu Val Arg Asn Val Val 
385                 390         


<210>  6
<211>  132
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  6

Met Ser Thr Thr Phe Ala Ala Arg Leu Asn Arg Leu Phe Asp Thr Val 
1               5                   10                  15      


Tyr Pro Pro Gly Arg Gly Pro His Thr Ser Ala Glu Val Ile Ala Ala 
            20                  25                  30          


Leu Lys Ala Glu Gly Ile Thr Met Ser Ala Pro Tyr Leu Ser Gln Leu 
        35                  40                  45              


Arg Ser Gly Asn Arg Thr Asn Pro Ser Gly Ala Thr Met Ala Ala Leu 
    50                  55                  60                  


Ala Asn Phe Phe Arg Ile Lys Ala Ala Tyr Phe Thr Asp Asp Glu Tyr 
65                  70                  75                  80  


Tyr Glu Lys Leu Asp Lys Glu Leu Gln Trp Leu Cys Thr Met Arg Asp 
                85                  90                  95      


Asp Gly Val Arg Arg Ile Ala Gln Arg Ala His Gly Leu Pro Ser Ala 
            100                 105                 110         


Ala Gln Gln Lys Val Leu Asp Arg Ile Asp Glu Leu Arg Arg Ala Glu 
        115                 120                 125             


Gly Ile Asp Ala 
    130         


<210>  7
<211>  1319
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  7

Met His His His His His His Gly Ser Thr Gln Ser Gln Thr Val Thr 
1               5                   10                  15      


Val Asp Gln Gln Glu Ile Leu Asn Arg Ala Asn Glu Val Glu Ala Pro 
            20                  25                  30          


Met Ala Asp Pro Pro Thr Asp Val Pro Ile Thr Pro Ser Glu Leu Thr 
        35                  40                  45              


Ala Ala Lys Asn Ala Ala Gln Gln Leu Val Leu Ser Ala Asp Asn Met 
    50                  55                  60                  


Arg Glu Tyr Leu Ala Ala Gly Ala Lys Glu Arg Gln Arg Leu Ala Thr 
65                  70                  75                  80  


Ser Leu Arg Asn Ala Ala Lys Ala Tyr Gly Glu Val Asp Glu Glu Ala 
                85                  90                  95      


Ala Thr Ala Leu Asp Asn Asp Gly Glu Gly Thr Val Gln Ala Glu Ser 
            100                 105                 110         


Ala Gly Ala Val Gly Gly Asp Ser Ser Ala Glu Leu Thr Asp Thr Pro 
        115                 120                 125             


Arg Val Ala Thr Ala Gly Glu Pro Asn Phe Met Asp Leu Lys Glu Ala 
    130                 135                 140                 


Ala Arg Lys Leu Glu Thr Gly Asp Gln Gly Ala Ser Leu Ala His Phe 
145                 150                 155                 160 


Ala Asp Gly Trp Asn Thr Phe Asn Leu Thr Leu Gln Gly Asp Val Lys 
                165                 170                 175     


Arg Phe Arg Gly Phe Asp Asn Trp Glu Gly Asp Ala Ala Thr Ala Ser 
            180                 185                 190         


Glu Ala Ser Leu Asp Gln Gln Arg Gln Trp Ile Leu His Met Ala Lys 
        195                 200                 205             


Leu Ser Ala Ala Met Ala Lys Gln Ala Gln Tyr Val Ala Gln Leu His 
    210                 215                 220                 


Val Trp Ala Arg Arg Glu His Pro Thr Tyr Glu Asp Ile Val Gly Leu 
225                 230                 235                 240 


Glu Arg Leu Tyr Ala Glu Asn Pro Ser Ala Arg Asp Gln Ile Leu Pro 
                245                 250                 255     


Val Tyr Ala Glu Tyr Gln Gln Arg Ser Glu Lys Val Leu Thr Glu Tyr 
            260                 265                 270         


Asn Asn Lys Ala Ala Leu Glu Pro Val Asn Pro Pro Lys Pro Pro Pro 
        275                 280                 285             


Ala Ile Lys Ile Asp Pro Pro Pro Pro Pro Gln Glu Gln Gly Leu Ile 
    290                 295                 300                 


Pro Gly Phe Leu Met Pro Pro Ser Asp Gly Ser Gly Val Thr Pro Gly 
305                 310                 315                 320 


Thr Gly Met Pro Ala Ala Pro Met Val Pro Pro Thr Gly Ser Pro Gly 
                325                 330                 335     


Gly Gly Leu Pro Ala Asp Thr Ala Ala Gln Leu Thr Ser Ala Gly Arg 
            340                 345                 350         


Glu Ala Ala Ala Leu Ser Gly Asp Val Ala Val Lys Ala Ala Ser Leu 
        355                 360                 365             


Gly Gly Gly Gly Gly Gly Gly Val Pro Ser Ala Pro Leu Gly Ser Ala 
    370                 375                 380                 


Ile Gly Gly Ala Glu Ser Val Arg Pro Ala Gly Ala Gly Asp Ile Ala 
385                 390                 395                 400 


Gly Leu Gly Gln Gly Arg Ala Gly Gly Gly Ala Ala Leu Gly Gly Gly 
                405                 410                 415     


Gly Met Gly Met Pro Met Gly Ala Ala His Gln Gly Gln Gly Gly Ala 
            420                 425                 430         


Lys Ser Lys Gly Ser Gln Gln Glu Asp Glu Ala Leu Tyr Thr Glu Asp 
        435                 440                 445             


Arg Ala Trp Thr Glu Ala Val Ile Gly Asn Arg Arg Arg Gln Asp Ser 
    450                 455                 460                 


Lys Glu Ser Lys Gly Ser Thr Glu Gln Gln Trp Asn Phe Ala Gly Ile 
465                 470                 475                 480 


Glu Ala Ala Ala Ser Ala Ile Gln Gly Asn Val Thr Ser Ile His Ser 
                485                 490                 495     


Leu Leu Asp Glu Gly Lys Gln Ser Leu Thr Lys Leu Ala Ala Ala Trp 
            500                 505                 510         


Gly Gly Ser Gly Ser Glu Ala Tyr Gln Gly Val Gln Gln Lys Trp Asp 
        515                 520                 525             


Ala Thr Ala Thr Glu Leu Asn Asn Ala Leu Gln Asn Leu Ala Arg Thr 
    530                 535                 540                 


Ile Ser Glu Ala Gly Gln Ala Met Ala Ser Thr Glu Gly Asn Val Thr 
545                 550                 555                 560 


Gly Met Phe Ala Glu Phe Asp Leu Pro Gly Asn Asp Phe Asp Ser Asn 
                565                 570                 575     


Asp Phe Asp Ala Val Asp Leu Trp Gly Ala Asp Gly Ala Glu Gly Trp 
            580                 585                 590         


Thr Ala Asp Pro Ile Ile Gly Val Gly Ser Ala Ala Thr Pro Asp Thr 
        595                 600                 605             


Gly Pro Asp Leu Asp Asn Ala His Gly Gln Ala Glu Thr Asp Thr Glu 
    610                 615                 620                 


Gln Glu Ile Ala Leu Phe Thr Val Thr Asn Pro Pro Arg Thr Val Ser 
625                 630                 635                 640 


Val Ser Thr Leu Met Asp Gly Arg Ile Asp His Val Glu Leu Ser Ala 
                645                 650                 655     


Arg Val Ala Trp Met Ser Glu Ser Gln Leu Ala Ser Glu Ile Leu Val 
            660                 665                 670         


Ile Ala Asp Leu Ala Arg Gln Lys Ala Gln Ser Ala Gln Tyr Ala Phe 
        675                 680                 685             


Ile Leu Asp Arg Met Ser Gln Gln Val Asp Ala Asp Glu His Arg Val 
    690                 695                 700                 


Ala Leu Leu Arg Lys Thr Val Gly Glu Thr Trp Gly Leu Pro Ser Pro 
705                 710                 715                 720 


Glu Glu Ala Ala Ala Ala Glu Ala Glu Val Phe Ala Thr Arg Tyr Ser 
                725                 730                 735     


Asp Asp Ser Pro Ala Pro Asp Asp Glu Ser Asp Pro Trp Thr Glu Asn 
            740                 745                 750         


Leu Thr Val Gln Pro Glu Arg Leu Gly Val Leu Ala Ser His His Asp 
        755                 760                 765             


Asn Ala Ala Val Asp Ala Ser Ser Gly Val Glu Ala Ala Ala Gly Leu 
    770                 775                 780                 


Gly Glu Ser Val Ala Ile Thr His Gly Pro Tyr Ser Ser Gln Phe Asn 
785                 790                 795                 800 


Asp Thr Leu Asn Val Tyr Leu Thr Ala His Asn Ala Leu Gly Ser Ser 
                805                 810                 815     


Leu His Thr Ala Gly Val Asp Leu Ala Lys Ser Leu Arg Ile Ala Ala 
            820                 825                 830         


Lys Ile Tyr Ser Glu Ala Asp Glu Ala Trp Arg Lys Ala Ile Asp Gly 
        835                 840                 845             


Leu Phe Thr Ser Arg Ala Phe Ile Ile Asp Pro Thr Ile Ser Ala Ile 
    850                 855                 860                 


Asp Gly Leu Tyr Asp Leu Leu Gly Ile Gly Ile Pro Asn Gln Gly Gly 
865                 870                 875                 880 


Ile Leu Tyr Ser Ser Leu Glu Tyr Phe Glu Lys Ala Leu Glu Glu Leu 
                885                 890                 895     


Ala Ala Ala Phe Pro Gly Asp Gly Trp Leu Gly Ser Ala Ala Asp Lys 
            900                 905                 910         


Tyr Ala Gly Lys Asn Arg Asn His Val Asn Phe Phe Gln Glu Leu Ala 
        915                 920                 925             


Asp Leu Asp Arg Gln Leu Ile Ser Leu Ile His Asp Gln Ala Asn Ala 
    930                 935                 940                 


Val Gln Thr Thr Arg Asp Ile Leu Glu Gly Ala Lys Lys Gly Leu Glu 
945                 950                 955                 960 


Phe Val Arg Pro Val Ala Val Asp Leu Thr Tyr Ile Pro Val Val Gly 
                965                 970                 975     


His Ala Leu Asp Val Ala Asp Ile Ile Lys Gly Thr Leu Gly Glu Val 
            980                 985                 990         


Trp Glu Phe Ile Thr Asn Ala Leu  Asn Gly Leu Lys Glu  Leu Trp Asp 
        995                 1000                 1005             


Lys Leu  Thr Gly Trp Val Thr  Gly Leu Phe Ser Arg  Gly Trp Ser 
    1010                 1015                 1020             


Asn Leu  Glu Ser Phe Phe Ala  Gly Val Pro Gly Leu  Thr Gly Ala 
    1025                 1030                 1035             


Thr Ser  Gly Leu Ser Gln Val  Thr Gly Leu Phe Gly  Ala Ala Gly 
    1040                 1045                 1050             


Leu Ser  Ala Ser Ser Gly Leu  Ala His Ala Asp Ser  Leu Ala Ser 
    1055                 1060                 1065             


Ser Ala  Ser Leu Pro Ala Leu  Ala Gly Ile Gly Gly  Gly Ser Gly 
    1070                 1075                 1080             


Phe Gly  Gly Leu Pro Ser Leu  Ala Gln Val His Ala  Ala Ser Thr 
    1085                 1090                 1095             


Arg Gln  Ala Leu Arg Pro Arg  Ala Asp Gly Pro Val  Gly Ala Ala 
    1100                 1105                 1110             


Ala Glu  Gln Val Gly Gly Gln  Ser Gln Leu Val Ser  Ala Gln Gly 
    1115                 1120                 1125             


Ser Gln  Gly Met Gly Gly Pro  Val Gly Met Gly Gly  Met His Pro 
    1130                 1135                 1140             


Ser Ser  Gly Ala Ser Lys Gly  Thr Thr Thr Lys Lys  Tyr Ser Glu 
    1145                 1150                 1155             


Gly Ala  Ala Ala Gly Thr Glu  Asp Ala Glu Arg Ala  Pro Val Glu 
    1160                 1165                 1170             


Ala Asp  Ala Gly Gly Gly Gln  Lys Val Leu Val Arg  Asn Val Val 
    1175                 1180                 1185             


Ser Thr  Thr Phe Ala Ala Arg  Leu Asn Arg Leu Phe  Asp Thr Val 
    1190                 1195                 1200             


Tyr Pro  Pro Gly Arg Gly Pro  His Thr Ser Ala Glu  Val Ile Ala 
    1205                 1210                 1215             


Ala Leu  Lys Ala Glu Gly Ile  Thr Met Ser Ala Pro  Tyr Leu Ser 
    1220                 1225                 1230             


Gln Leu  Arg Ser Gly Asn Arg  Thr Asn Pro Ser Gly  Ala Thr Met 
    1235                 1240                 1245             


Ala Ala  Leu Ala Asn Phe Phe  Arg Ile Lys Ala Ala  Tyr Phe Thr 
    1250                 1255                 1260             


Asp Asp  Glu Tyr Tyr Glu Lys  Leu Asp Lys Glu Leu  Gln Trp Leu 
    1265                 1270                 1275             


Ser Thr  Met Arg Asp Asp Gly  Val Arg Arg Ile Ala  Gln Arg Ala 
    1280                 1285                 1290             


His Gly  Leu Pro Ser Ala Ala  Gln Gln Lys Val Leu  Asp Arg Ile 
    1295                 1300                 1305             


Asp Glu  Leu Arg Arg Ala Glu  Gly Ile Asp Ala 
    1310                 1315                 


<210>  8
<211>  99
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  8

Met Glu Lys Met Ser His Asp Pro Ile Ala Ala Asp Ile Gly Thr Gln 
1               5                   10                  15      


Val Ser Asp Asn Ala Leu His Gly Val Thr Ala Gly Ser Thr Ala Leu 
            20                  25                  30          


Thr Ser Val Thr Gly Leu Val Pro Ala Gly Ala Asp Glu Val Ser Ala 
        35                  40                  45              


Gln Ala Ala Thr Ala Phe Thr Ser Glu Gly Ile Gln Leu Leu Ala Ser 
    50                  55                  60                  


Asn Ala Ser Ala Gln Asp Gln Leu His Arg Ala Gly Glu Ala Val Gln 
65                  70                  75                  80  


Asp Val Ala Arg Thr Tyr Ser Gln Ile Asp Asp Gly Ala Ala Gly Val 
                85                  90                  95      


Phe Ala Glu 
            


<210>  9
<211>  518
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  9

Met His His His His His His Gly Gly Ser Thr Glu Gln Gln Trp Asn 
1               5                   10                  15      


Phe Ala Gly Ile Glu Ala Ala Ala Ser Ala Ile Gln Gly Asn Val Thr 
            20                  25                  30          


Ser Ile His Ser Leu Leu Asp Glu Gly Lys Gln Ser Leu Thr Lys Leu 
        35                  40                  45              


Ala Ala Ala Trp Gly Gly Ser Gly Ser Glu Ala Tyr Gln Gly Val Gln 
    50                  55                  60                  


Gln Lys Trp Asp Ala Thr Ala Thr Glu Leu Asn Asn Ala Leu Gln Asn 
65                  70                  75                  80  


Leu Ala Arg Thr Ile Ser Glu Ala Gly Gln Ala Met Ala Ser Thr Glu 
                85                  90                  95      


Gly Asn Val Thr Gly Met Phe Ala Glu Phe Asp Leu Pro Gly Asn Asp 
            100                 105                 110         


Phe Asp Ser Asn Asp Phe Asp Ala Val Asp Leu Trp Gly Ala Asp Gly 
        115                 120                 125             


Ala Glu Gly Trp Thr Ala Asp Pro Ile Ile Gly Val Gly Ser Ala Ala 
    130                 135                 140                 


Thr Pro Asp Thr Gly Pro Asp Leu Asp Asn Ala His Gly Gln Ala Glu 
145                 150                 155                 160 


Thr Asp Thr Glu Gln Glu Ile Ala Leu Phe Thr Val Thr Asn Pro Pro 
                165                 170                 175     


Arg Thr Val Ser Val Ser Thr Leu Met Asp Gly Arg Ile Asp His Val 
            180                 185                 190         


Glu Leu Ser Ala Arg Val Ala Trp Met Ser Glu Ser Gln Leu Ala Ser 
        195                 200                 205             


Glu Ile Leu Val Ile Ala Asp Leu Ala Arg Gln Lys Ala Gln Ser Ala 
    210                 215                 220                 


Gln Tyr Ala Phe Ile Leu Asp Arg Met Ser Gln Gln Val Asp Ala Asp 
225                 230                 235                 240 


Glu His Arg Val Ala Leu Leu Arg Lys Thr Val Gly Glu Thr Trp Gly 
                245                 250                 255     


Leu Pro Ser Pro Glu Glu Ala Ala Ala Ala Glu Ala Glu Val Phe Ala 
            260                 265                 270         


Thr Arg Tyr Ser Asp Asp Ser Pro Ala Pro Asp Asp Glu Ser Asp Pro 
        275                 280                 285             


Trp Ser Thr Thr Phe Ala Ala Arg Leu Asn Arg Leu Phe Asp Thr Val 
    290                 295                 300                 


Tyr Pro Pro Gly Arg Gly Pro His Thr Ser Ala Glu Val Ile Ala Ala 
305                 310                 315                 320 


Leu Lys Ala Glu Gly Ile Thr Met Ser Ala Pro Tyr Leu Ser Gln Leu 
                325                 330                 335     


Arg Ser Gly Asn Arg Thr Asn Pro Ser Gly Ala Thr Met Ala Ala Leu 
            340                 345                 350         


Ala Asn Phe Phe Arg Ile Lys Ala Ala Tyr Phe Thr Asp Asp Glu Tyr 
        355                 360                 365             


Tyr Glu Lys Leu Asp Lys Glu Leu Gln Trp Leu Ser Thr Met Arg Asp 
    370                 375                 380                 


Asp Gly Val Arg Arg Ile Ala Gln Arg Ala His Gly Leu Pro Ser Ala 
385                 390                 395                 400 


Ala Gln Gln Lys Val Leu Asp Arg Ile Asp Glu Leu Arg Arg Ala Glu 
                405                 410                 415     


Gly Ile Asp Ala Glu Lys Met Ser His Asp Pro Ile Ala Ala Asp Ile 
            420                 425                 430         


Gly Thr Gln Val Ser Asp Asn Ala Leu His Gly Val Thr Ala Gly Ser 
        435                 440                 445             


Thr Ala Leu Thr Ser Val Thr Gly Leu Val Pro Ala Gly Ala Asp Glu 
    450                 455                 460                 


Val Ser Ala Gln Ala Ala Thr Ala Phe Thr Ser Glu Gly Ile Gln Leu 
465                 470                 475                 480 


Leu Ala Ser Asn Ala Ser Ala Gln Asp Gln Leu His Arg Ala Gly Glu 
                485                 490                 495     


Ala Val Gln Asp Val Ala Arg Thr Tyr Ser Gln Ile Asp Asp Gly Ala 
            500                 505                 510         


Ala Gly Val Phe Ala Glu 
        515             


<210>  10
<211>  1217
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  10

Met His His His His His His Gly Ser Thr Gln Ser Gln Thr Val Thr 
1               5                   10                  15      


Val Asp Gln Gln Glu Ile Leu Asn Arg Ala Asn Glu Val Glu Ala Pro 
            20                  25                  30          


Met Ala Asp Pro Pro Thr Asp Val Pro Ile Thr Pro Ser Glu Leu Thr 
        35                  40                  45              


Ala Ala Lys Asn Ala Ala Gln Gln Leu Val Leu Ser Ala Asp Asn Met 
    50                  55                  60                  


Arg Glu Tyr Leu Ala Ala Gly Ala Lys Glu Arg Gln Arg Leu Ala Thr 
65                  70                  75                  80  


Ser Leu Arg Asn Ala Ala Lys Ala Tyr Gly Glu Val Asp Glu Glu Ala 
                85                  90                  95      


Ala Thr Ala Leu Asp Asn Asp Gly Glu Gly Thr Val Gln Ala Glu Ser 
            100                 105                 110         


Ala Gly Ala Val Gly Gly Asp Ser Ser Ala Glu Leu Thr Asp Thr Pro 
        115                 120                 125             


Arg Val Ala Thr Ala Gly Glu Pro Asn Phe Met Asp Leu Lys Glu Ala 
    130                 135                 140                 


Ala Arg Lys Leu Glu Thr Gly Asp Gln Gly Ala Ser Leu Ala His Phe 
145                 150                 155                 160 


Ala Asp Gly Trp Asn Thr Phe Asn Leu Thr Leu Gln Gly Asp Val Lys 
                165                 170                 175     


Arg Phe Arg Gly Phe Asp Asn Trp Glu Gly Asp Ala Ala Thr Ala Ser 
            180                 185                 190         


Glu Ala Ser Leu Asp Gln Gln Arg Gln Trp Ile Leu His Met Ala Lys 
        195                 200                 205             


Leu Ser Ala Ala Met Ala Lys Gln Ala Gln Tyr Val Ala Gln Leu His 
    210                 215                 220                 


Val Trp Ala Arg Arg Glu His Pro Thr Tyr Glu Asp Ile Val Gly Leu 
225                 230                 235                 240 


Glu Arg Leu Tyr Ala Glu Asn Pro Ser Ala Arg Asp Gln Ile Leu Pro 
                245                 250                 255     


Val Tyr Ala Glu Tyr Gln Gln Arg Ser Glu Lys Val Leu Thr Glu Tyr 
            260                 265                 270         


Asn Asn Lys Ala Ala Leu Glu Pro Val Asn Pro Pro Lys Pro Pro Pro 
        275                 280                 285             


Ala Ile Lys Ile Asp Pro Pro Pro Pro Pro Gln Glu Gln Gly Leu Ile 
    290                 295                 300                 


Pro Gly Phe Leu Met Pro Pro Ser Asp Gly Ser Gly Val Thr Pro Gly 
305                 310                 315                 320 


Thr Gly Met Pro Ala Ala Pro Met Val Pro Pro Thr Gly Ser Pro Gly 
                325                 330                 335     


Gly Gly Leu Pro Ala Asp Thr Ala Ala Gln Leu Thr Ser Ala Gly Arg 
            340                 345                 350         


Glu Ala Ala Ala Leu Ser Gly Asp Val Ala Val Lys Ala Ala Ser Leu 
        355                 360                 365             


Gly Gly Gly Gly Gly Gly Gly Val Pro Ser Ala Pro Leu Gly Ser Ala 
    370                 375                 380                 


Ile Gly Gly Ala Glu Ser Val Arg Pro Ala Gly Ala Gly Asp Ile Ala 
385                 390                 395                 400 


Gly Leu Gly Gln Gly Arg Ala Gly Gly Gly Ala Ala Leu Gly Gly Gly 
                405                 410                 415     


Gly Met Gly Met Pro Met Gly Ala Ala His Gln Gly Gln Gly Gly Ala 
            420                 425                 430         


Lys Ser Lys Gly Ser Gln Gln Glu Asp Glu Ala Leu Tyr Thr Glu Asp 
        435                 440                 445             


Arg Ala Trp Thr Glu Ala Val Ile Gly Asn Arg Arg Arg Gln Asp Ser 
    450                 455                 460                 


Lys Glu Ser Lys Gly Ser Thr Glu Gln Gln Trp Asn Phe Ala Gly Ile 
465                 470                 475                 480 


Glu Ala Ala Ala Ser Ala Ile Gln Gly Asn Val Thr Ser Ile His Ser 
                485                 490                 495     


Leu Leu Asp Glu Gly Lys Gln Ser Leu Thr Lys Leu Ala Ala Ala Trp 
            500                 505                 510         


Gly Gly Ser Gly Ser Glu Ala Tyr Gln Gly Val Gln Gln Lys Trp Asp 
        515                 520                 525             


Ala Thr Ala Thr Glu Leu Asn Asn Ala Leu Gln Asn Leu Ala Arg Thr 
    530                 535                 540                 


Ile Ser Glu Ala Gly Gln Ala Met Ala Ser Thr Glu Gly Asn Val Thr 
545                 550                 555                 560 


Gly Met Phe Ala Glu Phe Asp Leu Pro Gly Asn Asp Phe Asp Ser Asn 
                565                 570                 575     


Asp Phe Asp Ala Val Asp Leu Trp Gly Ala Asp Gly Ala Glu Gly Trp 
            580                 585                 590         


Thr Ala Asp Pro Ile Ile Gly Val Gly Ser Ala Ala Thr Pro Asp Thr 
        595                 600                 605             


Gly Pro Asp Leu Asp Asn Ala His Gly Gln Ala Glu Thr Asp Thr Glu 
    610                 615                 620                 


Gln Glu Ile Ala Leu Phe Thr Val Thr Asn Pro Pro Arg Thr Val Ser 
625                 630                 635                 640 


Val Ser Thr Leu Met Asp Gly Arg Ile Asp His Val Glu Leu Ser Ala 
                645                 650                 655     


Arg Val Ala Trp Met Ser Glu Ser Gln Leu Ala Ser Glu Ile Leu Val 
            660                 665                 670         


Ile Ala Asp Leu Ala Arg Gln Lys Ala Gln Ser Ala Gln Tyr Ala Phe 
        675                 680                 685             


Ile Leu Asp Arg Met Ser Gln Gln Val Asp Ala Asp Glu His Arg Val 
    690                 695                 700                 


Ala Leu Leu Arg Lys Thr Val Gly Glu Thr Trp Gly Leu Pro Ser Pro 
705                 710                 715                 720 


Glu Glu Ala Ala Ala Ala Glu Ala Glu Val Phe Ala Thr Arg Tyr Ser 
                725                 730                 735     


Asp Asp Ser Pro Ala Pro Asp Asp Glu Ser Asp Pro Trp Ser Arg Ala 
            740                 745                 750         


Phe Ile Ile Asp Pro Thr Ile Ser Ala Ile Asp Gly Leu Tyr Asp Leu 
        755                 760                 765             


Leu Gly Ile Gly Ile Pro Asn Gln Gly Gly Ile Leu Tyr Ser Ser Leu 
    770                 775                 780                 


Glu Tyr Phe Glu Lys Ala Leu Glu Glu Leu Ala Ala Ala Phe Pro Gly 
785                 790                 795                 800 


Asp Gly Trp Leu Gly Ser Ala Ala Asp Lys Tyr Ala Gly Lys Asn Arg 
                805                 810                 815     


Asn His Val Asn Phe Phe Gln Glu Leu Ala Asp Leu Asp Arg Gln Leu 
            820                 825                 830         


Ile Ser Leu Ile His Asp Gln Ala Asn Ala Val Gln Thr Thr Arg Asp 
        835                 840                 845             


Ile Leu Glu Gly Ala Lys Lys Gly Leu Glu Phe Val Arg Pro Val Ala 
    850                 855                 860                 


Val Asp Leu Thr Tyr Ile Pro Val Val Gly His Ala Leu Asp Val Ala 
865                 870                 875                 880 


Asp Ile Ile Lys Gly Thr Leu Gly Glu Val Trp Glu Phe Ile Thr Asn 
                885                 890                 895     


Ala Leu Asn Gly Leu Lys Glu Leu Trp Asp Lys Leu Thr Gly Trp Val 
            900                 905                 910         


Thr Gly Leu Phe Ser Arg Gly Trp Ser Asn Leu Glu Ser Phe Phe Ala 
        915                 920                 925             


Gly Val Pro Gly Leu Thr Gly Ala Thr Ser Gly Leu Ser Gln Val Thr 
    930                 935                 940                 


Gly Leu Phe Gly Ala Ala Gly Leu Ser Ala Ser Ser Gly Leu Ala His 
945                 950                 955                 960 


Ala Asp Ser Leu Ala Ser Ser Ala Ser Leu Pro Ala Leu Ala Gly Ile 
                965                 970                 975     


Gly Gly Gly Ser Gly Phe Gly Gly Leu Pro Ser Leu Ala Gln Val His 
            980                 985                 990         


Ala Ala Ser Thr Arg Gln Ala Leu  Arg Pro Arg Ala Asp  Gly Pro Val 
        995                 1000                 1005             


Gly Ala  Ala Ala Glu Gln Val  Gly Gly Gln Ser Gln  Leu Val Ser 
    1010                 1015                 1020             


Ala Gln  Gly Ser Gln Gly Met  Gly Gly Pro Val Gly  Met Gly Gly 
    1025                 1030                 1035             


Met His  Pro Ser Ser Gly Ala  Ser Lys Gly Thr Thr  Thr Lys Lys 
    1040                 1045                 1050             


Tyr Ser  Glu Gly Ala Ala Ala  Gly Thr Glu Asp Ala  Glu Arg Ala 
    1055                 1060                 1065             


Pro Val  Glu Ala Asp Ala Gly  Gly Gly Gln Lys Val  Leu Val Arg 
    1070                 1075                 1080             


Asn Val  Val Ser Thr Thr Phe  Ala Ala Arg Leu Asn  Arg Leu Phe 
    1085                 1090                 1095             


Asp Thr  Val Tyr Pro Pro Gly  Arg Gly Pro His Thr  Ser Ala Glu 
    1100                 1105                 1110             


Val Ile  Ala Ala Leu Lys Ala  Glu Gly Ile Thr Met  Ser Ala Pro 
    1115                 1120                 1125             


Tyr Leu  Ser Gln Leu Arg Ser  Gly Asn Arg Thr Asn  Pro Ser Gly 
    1130                 1135                 1140             


Ala Thr  Met Ala Ala Leu Ala  Asn Phe Phe Arg Ile  Lys Ala Ala 
    1145                 1150                 1155             


Tyr Phe  Thr Asp Asp Glu Tyr  Tyr Glu Lys Leu Asp  Lys Glu Leu 
    1160                 1165                 1170             


Gln Trp  Leu Ser Thr Met Arg  Asp Asp Gly Val Arg  Arg Ile Ala 
    1175                 1180                 1185             


Gln Arg  Ala His Gly Leu Pro  Ser Ala Ala Gln Gln  Lys Val Leu 
    1190                 1195                 1200             


Asp Arg  Ile Asp Glu Leu Arg  Arg Ala Glu Gly Ile  Asp Ala 
    1205                 1210                 1215         


<210>  11
<211>  335
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  11

Met His His His His His His Gly Gly Ser Thr Glu Gln Gln Trp Asn 
1               5                   10                  15      


Phe Ala Gly Ile Glu Ala Ala Ala Ser Ala Ile Gln Gly Asn Val Thr 
            20                  25                  30          


Ser Ile His Ser Leu Leu Asp Glu Gly Lys Gln Ser Leu Thr Lys Leu 
        35                  40                  45              


Ala Ala Ala Trp Gly Gly Ser Gly Ser Glu Ala Tyr Gln Gly Val Gln 
    50                  55                  60                  


Gln Lys Trp Asp Ala Thr Ala Thr Glu Leu Asn Asn Ala Leu Gln Asn 
65                  70                  75                  80  


Leu Ala Arg Thr Ile Ser Glu Ala Gly Gln Ala Met Ala Ser Thr Glu 
                85                  90                  95      


Gly Asn Val Thr Gly Met Phe Ala Glu Phe Ser Thr Thr Phe Ala Ala 
            100                 105                 110         


Arg Leu Asn Arg Leu Phe Asp Thr Val Tyr Pro Pro Gly Arg Gly Pro 
        115                 120                 125             


His Thr Ser Ala Glu Val Ile Ala Ala Leu Lys Ala Glu Gly Ile Thr 
    130                 135                 140                 


Met Ser Ala Pro Tyr Leu Ser Gln Leu Arg Ser Gly Asn Arg Thr Asn 
145                 150                 155                 160 


Pro Ser Gly Ala Thr Met Ala Ala Leu Ala Asn Phe Phe Arg Ile Lys 
                165                 170                 175     


Ala Ala Tyr Phe Thr Asp Asp Glu Tyr Tyr Glu Lys Leu Asp Lys Glu 
            180                 185                 190         


Leu Gln Trp Leu Ser Thr Met Arg Asp Asp Gly Val Arg Arg Ile Ala 
        195                 200                 205             


Gln Arg Ala His Gly Leu Pro Ser Ala Ala Gln Gln Lys Val Leu Asp 
    210                 215                 220                 


Arg Ile Asp Glu Leu Arg Arg Ala Glu Gly Ile Asp Ala Glu Lys Met 
225                 230                 235                 240 


Ser His Asp Pro Ile Ala Ala Asp Ile Gly Thr Gln Val Ser Asp Asn 
                245                 250                 255     


Ala Leu His Gly Val Thr Ala Gly Ser Thr Ala Leu Thr Ser Val Thr 
            260                 265                 270         


Gly Leu Val Pro Ala Gly Ala Asp Glu Val Ser Ala Gln Ala Ala Thr 
        275                 280                 285             


Ala Phe Thr Ser Glu Gly Ile Gln Leu Leu Ala Ser Asn Ala Ser Ala 
    290                 295                 300                 


Gln Asp Gln Leu His Arg Ala Gly Glu Ala Val Gln Asp Val Ala Arg 
305                 310                 315                 320 


Thr Tyr Ser Gln Ile Asp Asp Gly Ala Ala Gly Val Phe Ala Glu 
                325                 330                 335 


<210>  12
<211>  1034
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  12

Met His His His His His His Gly Ser Thr Gln Ser Gln Thr Val Thr 
1               5                   10                  15      


Val Asp Gln Gln Glu Ile Leu Asn Arg Ala Asn Glu Val Glu Ala Pro 
            20                  25                  30          


Met Ala Asp Pro Pro Thr Asp Val Pro Ile Thr Pro Ser Glu Leu Thr 
        35                  40                  45              


Ala Ala Lys Asn Ala Ala Gln Gln Leu Val Leu Ser Ala Asp Asn Met 
    50                  55                  60                  


Arg Glu Tyr Leu Ala Ala Gly Ala Lys Glu Arg Gln Arg Leu Ala Thr 
65                  70                  75                  80  


Ser Leu Arg Asn Ala Ala Lys Ala Tyr Gly Glu Val Asp Glu Glu Ala 
                85                  90                  95      


Ala Thr Ala Leu Asp Asn Asp Gly Glu Gly Thr Val Gln Ala Glu Ser 
            100                 105                 110         


Ala Gly Ala Val Gly Gly Asp Ser Ser Ala Glu Leu Thr Asp Thr Pro 
        115                 120                 125             


Arg Val Ala Thr Ala Gly Glu Pro Asn Phe Met Asp Leu Lys Glu Ala 
    130                 135                 140                 


Ala Arg Lys Leu Glu Thr Gly Asp Gln Gly Ala Ser Leu Ala His Phe 
145                 150                 155                 160 


Ala Asp Gly Trp Asn Thr Phe Asn Leu Thr Leu Gln Gly Asp Val Lys 
                165                 170                 175     


Arg Phe Arg Gly Phe Asp Asn Trp Glu Gly Asp Ala Ala Thr Ala Ser 
            180                 185                 190         


Glu Ala Ser Leu Asp Gln Gln Arg Gln Trp Ile Leu His Met Ala Lys 
        195                 200                 205             


Leu Ser Ala Ala Met Ala Lys Gln Ala Gln Tyr Val Ala Gln Leu His 
    210                 215                 220                 


Val Trp Ala Arg Arg Glu His Pro Thr Tyr Glu Asp Ile Val Gly Leu 
225                 230                 235                 240 


Glu Arg Leu Tyr Ala Glu Asn Pro Ser Ala Arg Asp Gln Ile Leu Pro 
                245                 250                 255     


Val Tyr Ala Glu Tyr Gln Gln Arg Ser Glu Lys Val Leu Thr Glu Tyr 
            260                 265                 270         


Asn Asn Lys Ala Ala Leu Glu Pro Val Asn Pro Pro Lys Pro Pro Pro 
        275                 280                 285             


Ala Ile Lys Ile Asp Pro Pro Pro Pro Pro Gln Glu Gln Gly Leu Ile 
    290                 295                 300                 


Pro Gly Phe Leu Met Pro Pro Ser Asp Gly Ser Gly Val Thr Pro Gly 
305                 310                 315                 320 


Thr Gly Met Pro Ala Ala Pro Met Val Pro Pro Thr Gly Ser Pro Gly 
                325                 330                 335     


Gly Gly Leu Pro Ala Asp Thr Ala Ala Gln Leu Thr Ser Ala Gly Arg 
            340                 345                 350         


Glu Ala Ala Ala Leu Ser Gly Asp Val Ala Val Lys Ala Ala Ser Leu 
        355                 360                 365             


Gly Gly Gly Gly Gly Gly Gly Val Pro Ser Ala Pro Leu Gly Ser Ala 
    370                 375                 380                 


Ile Gly Gly Ala Glu Ser Val Arg Pro Ala Gly Ala Gly Asp Ile Ala 
385                 390                 395                 400 


Gly Leu Gly Gln Gly Arg Ala Gly Gly Gly Ala Ala Leu Gly Gly Gly 
                405                 410                 415     


Gly Met Gly Met Pro Met Gly Ala Ala His Gln Gly Gln Gly Gly Ala 
            420                 425                 430         


Lys Ser Lys Gly Ser Gln Gln Glu Asp Glu Ala Leu Tyr Thr Glu Asp 
        435                 440                 445             


Arg Ala Trp Thr Glu Ala Val Ile Gly Asn Arg Arg Arg Gln Asp Ser 
    450                 455                 460                 


Lys Glu Ser Lys Gly Ser Thr Glu Gln Gln Trp Asn Phe Ala Gly Ile 
465                 470                 475                 480 


Glu Ala Ala Ala Ser Ala Ile Gln Gly Asn Val Thr Ser Ile His Ser 
                485                 490                 495     


Leu Leu Asp Glu Gly Lys Gln Ser Leu Thr Lys Leu Ala Ala Ala Trp 
            500                 505                 510         


Gly Gly Ser Gly Ser Glu Ala Tyr Gln Gly Val Gln Gln Lys Trp Asp 
        515                 520                 525             


Ala Thr Ala Thr Glu Leu Asn Asn Ala Leu Gln Asn Leu Ala Arg Thr 
    530                 535                 540                 


Ile Ser Glu Ala Gly Gln Ala Met Ala Ser Thr Glu Gly Asn Val Thr 
545                 550                 555                 560 


Gly Met Phe Ala Glu Phe Ser Arg Ala Phe Ile Ile Asp Pro Thr Ile 
                565                 570                 575     


Ser Ala Ile Asp Gly Leu Tyr Asp Leu Leu Gly Ile Gly Ile Pro Asn 
            580                 585                 590         


Gln Gly Gly Ile Leu Tyr Ser Ser Leu Glu Tyr Phe Glu Lys Ala Leu 
        595                 600                 605             


Glu Glu Leu Ala Ala Ala Phe Pro Gly Asp Gly Trp Leu Gly Ser Ala 
    610                 615                 620                 


Ala Asp Lys Tyr Ala Gly Lys Asn Arg Asn His Val Asn Phe Phe Gln 
625                 630                 635                 640 


Glu Leu Ala Asp Leu Asp Arg Gln Leu Ile Ser Leu Ile His Asp Gln 
                645                 650                 655     


Ala Asn Ala Val Gln Thr Thr Arg Asp Ile Leu Glu Gly Ala Lys Lys 
            660                 665                 670         


Gly Leu Glu Phe Val Arg Pro Val Ala Val Asp Leu Thr Tyr Ile Pro 
        675                 680                 685             


Val Val Gly His Ala Leu Asp Val Ala Asp Ile Ile Lys Gly Thr Leu 
    690                 695                 700                 


Gly Glu Val Trp Glu Phe Ile Thr Asn Ala Leu Asn Gly Leu Lys Glu 
705                 710                 715                 720 


Leu Trp Asp Lys Leu Thr Gly Trp Val Thr Gly Leu Phe Ser Arg Gly 
                725                 730                 735     


Trp Ser Asn Leu Glu Ser Phe Phe Ala Gly Val Pro Gly Leu Thr Gly 
            740                 745                 750         


Ala Thr Ser Gly Leu Ser Gln Val Thr Gly Leu Phe Gly Ala Ala Gly 
        755                 760                 765             


Leu Ser Ala Ser Ser Gly Leu Ala His Ala Asp Ser Leu Ala Ser Ser 
    770                 775                 780                 


Ala Ser Leu Pro Ala Leu Ala Gly Ile Gly Gly Gly Ser Gly Phe Gly 
785                 790                 795                 800 


Gly Leu Pro Ser Leu Ala Gln Val His Ala Ala Ser Thr Arg Gln Ala 
                805                 810                 815     


Leu Arg Pro Arg Ala Asp Gly Pro Val Gly Ala Ala Ala Glu Gln Val 
            820                 825                 830         


Gly Gly Gln Ser Gln Leu Val Ser Ala Gln Gly Ser Gln Gly Met Gly 
        835                 840                 845             


Gly Pro Val Gly Met Gly Gly Met His Pro Ser Ser Gly Ala Ser Lys 
    850                 855                 860                 


Gly Thr Thr Thr Lys Lys Tyr Ser Glu Gly Ala Ala Ala Gly Thr Glu 
865                 870                 875                 880 


Asp Ala Glu Arg Ala Pro Val Glu Ala Asp Ala Gly Gly Gly Gln Lys 
                885                 890                 895     


Val Leu Val Arg Asn Val Val Ser Thr Thr Phe Ala Ala Arg Leu Asn 
            900                 905                 910         


Arg Leu Phe Asp Thr Val Tyr Pro Pro Gly Arg Gly Pro His Thr Ser 
        915                 920                 925             


Ala Glu Val Ile Ala Ala Leu Lys Ala Glu Gly Ile Thr Met Ser Ala 
    930                 935                 940                 


Pro Tyr Leu Ser Gln Leu Arg Ser Gly Asn Arg Thr Asn Pro Ser Gly 
945                 950                 955                 960 


Ala Thr Met Ala Ala Leu Ala Asn Phe Phe Arg Ile Lys Ala Ala Tyr 
                965                 970                 975     


Phe Thr Asp Asp Glu Tyr Tyr Glu Lys Leu Asp Lys Glu Leu Gln Trp 
            980                 985                 990         


Leu Ser Thr Met Arg Asp Asp Gly  Val Arg Arg Ile Ala  Gln Arg Ala 
        995                 1000                 1005             


His Gly  Leu Pro Ser Ala Ala  Gln Gln Lys Val Leu  Asp Arg Ile 
    1010                 1015                 1020             


Asp Glu  Leu Arg Arg Ala Glu  Gly Ile Asp Ala 
    1025                 1030                 


<210>  13
<211>  697
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  13

Met His His His His His His Gly Ser Thr Gln Ser Gln Thr Val Thr 
1               5                   10                  15      


Val Asp Gln Gln Glu Ile Leu Asn Arg Ala Asn Glu Val Glu Ala Pro 
            20                  25                  30          


Met Ala Asp Pro Pro Thr Asp Val Pro Ile Thr Pro Ser Glu Leu Thr 
        35                  40                  45              


Ala Ala Lys Asn Ala Ala Gln Gln Leu Val Leu Ser Ala Asp Asn Met 
    50                  55                  60                  


Arg Glu Tyr Leu Ala Ala Gly Ala Lys Glu Arg Gln Arg Leu Ala Thr 
65                  70                  75                  80  


Ser Leu Arg Asn Ala Ala Lys Ala Tyr Gly Glu Val Asp Glu Glu Ala 
                85                  90                  95      


Ala Thr Ala Leu Asp Asn Asp Gly Glu Gly Thr Val Gln Ala Glu Ser 
            100                 105                 110         


Ala Gly Ala Val Gly Gly Asp Ser Ser Ala Glu Leu Thr Asp Thr Pro 
        115                 120                 125             


Arg Val Ala Thr Ala Gly Glu Pro Asn Phe Met Asp Leu Lys Glu Ala 
    130                 135                 140                 


Ala Arg Lys Leu Glu Thr Gly Asp Gln Gly Ala Ser Leu Ala His Phe 
145                 150                 155                 160 


Ala Asp Gly Trp Asn Thr Phe Asn Leu Thr Leu Gln Gly Asp Val Lys 
                165                 170                 175     


Arg Phe Arg Gly Phe Asp Asn Trp Glu Gly Asp Ala Ala Thr Ala Ser 
            180                 185                 190         


Glu Ala Ser Leu Asp Gln Gln Arg Gln Trp Ile Leu His Met Ala Lys 
        195                 200                 205             


Leu Ser Ala Ala Met Ala Lys Gln Ala Gln Tyr Val Ala Gln Leu His 
    210                 215                 220                 


Val Trp Ala Arg Arg Glu His Pro Thr Tyr Glu Asp Ile Val Gly Leu 
225                 230                 235                 240 


Glu Arg Leu Tyr Ala Glu Asn Pro Ser Ala Arg Asp Gln Ile Leu Pro 
                245                 250                 255     


Val Tyr Ala Glu Tyr Gln Gln Arg Ser Glu Lys Val Leu Thr Glu Tyr 
            260                 265                 270         


Asn Asn Lys Ala Ala Leu Glu Pro Val Asn Pro Pro Lys Pro Pro Pro 
        275                 280                 285             


Ala Ile Lys Ile Asp Pro Pro Pro Pro Pro Gln Glu Gln Gly Leu Ile 
    290                 295                 300                 


Pro Gly Phe Leu Met Pro Pro Ser Asp Gly Ser Gly Val Thr Pro Gly 
305                 310                 315                 320 


Thr Gly Met Pro Ala Ala Pro Met Val Pro Pro Thr Gly Ser Pro Gly 
                325                 330                 335     


Gly Gly Leu Pro Ala Asp Thr Ala Ala Gln Leu Thr Ser Ala Gly Arg 
            340                 345                 350         


Glu Ala Ala Ala Leu Ser Gly Asp Val Ala Val Lys Ala Ala Ser Leu 
        355                 360                 365             


Gly Gly Gly Gly Gly Gly Gly Val Pro Ser Ala Pro Leu Gly Ser Ala 
    370                 375                 380                 


Ile Gly Gly Ala Glu Ser Val Arg Pro Ala Gly Ala Gly Asp Ile Ala 
385                 390                 395                 400 


Gly Leu Gly Gln Gly Arg Ala Gly Gly Gly Ala Ala Leu Gly Gly Gly 
                405                 410                 415     


Gly Met Gly Met Pro Met Gly Ala Ala His Gln Gly Gln Gly Gly Ala 
            420                 425                 430         


Lys Ser Lys Gly Ser Gln Gln Glu Asp Glu Ala Leu Tyr Thr Glu Asp 
        435                 440                 445             


Arg Ala Trp Thr Glu Ala Val Ile Gly Asn Arg Arg Arg Gln Asp Ser 
    450                 455                 460                 


Lys Glu Ser Lys Gly Ser Thr Glu Gln Gln Trp Asn Phe Ala Gly Ile 
465                 470                 475                 480 


Glu Ala Ala Ala Ser Ala Ile Gln Gly Asn Val Thr Ser Ile His Ser 
                485                 490                 495     


Leu Leu Asp Glu Gly Lys Gln Ser Leu Thr Lys Leu Ala Ala Ala Trp 
            500                 505                 510         


Gly Gly Ser Gly Ser Glu Ala Tyr Gln Gly Val Gln Gln Lys Trp Asp 
        515                 520                 525             


Ala Thr Ala Thr Glu Leu Asn Asn Ala Leu Gln Asn Leu Ala Arg Thr 
    530                 535                 540                 


Ile Ser Glu Ala Gly Gln Ala Met Ala Ser Thr Glu Gly Asn Val Thr 
545                 550                 555                 560 


Gly Met Phe Ala Glu Phe Ser Thr Thr Phe Ala Ala Arg Leu Asn Arg 
                565                 570                 575     


Leu Phe Asp Thr Val Tyr Pro Pro Gly Arg Gly Pro His Thr Ser Ala 
            580                 585                 590         


Glu Val Ile Ala Ala Leu Lys Ala Glu Gly Ile Thr Met Ser Ala Pro 
        595                 600                 605             


Tyr Leu Ser Gln Leu Arg Ser Gly Asn Arg Thr Asn Pro Ser Gly Ala 
    610                 615                 620                 


Thr Met Ala Ala Leu Ala Asn Phe Phe Arg Ile Lys Ala Ala Tyr Phe 
625                 630                 635                 640 


Thr Asp Asp Glu Tyr Tyr Glu Lys Leu Asp Lys Glu Leu Gln Trp Leu 
                645                 650                 655     


Ser Thr Met Arg Asp Asp Gly Val Arg Arg Ile Ala Gln Arg Ala His 
            660                 665                 670         


Gly Leu Pro Ser Ala Ala Gln Gln Lys Val Leu Asp Arg Ile Asp Glu 
        675                 680                 685             


Leu Arg Arg Ala Glu Gly Ile Asp Ala 
    690                 695         


<210>  14
<211>  572
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  14

Met His His His His His His Thr Glu Gln Gln Trp Asn Phe Ala Gly 
1               5                   10                  15      


Ile Glu Ala Ala Ala Ser Ala Ile Gln Gly Asn Val Thr Ser Ile His 
            20                  25                  30          


Ser Leu Leu Asp Glu Gly Lys Gln Ser Leu Thr Lys Leu Ala Ala Ala 
        35                  40                  45              


Trp Gly Gly Ser Gly Ser Glu Ala Tyr Gln Gly Val Gln Gln Lys Trp 
    50                  55                  60                  


Asp Ala Thr Ala Thr Glu Leu Asn Asn Ala Leu Gln Asn Leu Ala Arg 
65                  70                  75                  80  


Thr Ile Ser Glu Ala Gly Gln Ala Met Ala Ser Thr Glu Gly Asn Val 
                85                  90                  95      


Thr Gly Met Phe Ala Met Asp Leu Pro Gly Asn Asp Phe Asp Ser Asn 
            100                 105                 110         


Asp Phe Asp Ala Val Asp Leu Trp Gly Ala Asp Gly Ala Glu Gly Trp 
        115                 120                 125             


Thr Ala Asp Pro Ile Ile Gly Val Gly Ser Ala Ala Thr Pro Asp Thr 
    130                 135                 140                 


Gly Pro Asp Leu Asp Asn Ala His Gly Gln Ala Glu Thr Asp Thr Glu 
145                 150                 155                 160 


Gln Glu Ile Ala Leu Phe Thr Val Thr Asn Pro Pro Arg Thr Val Ser 
                165                 170                 175     


Val Ser Thr Leu Met Asp Gly Arg Ile Asp His Val Glu Leu Ser Ala 
            180                 185                 190         


Arg Val Ala Trp Met Ser Glu Ser Gln Leu Ala Ser Glu Ile Leu Val 
        195                 200                 205             


Ile Ala Asp Leu Ala Arg Gln Lys Ala Gln Ser Ala Gln Tyr Ala Phe 
    210                 215                 220                 


Ile Leu Asp Arg Met Ser Gln Gln Val Asp Ala Asp Glu His Arg Val 
225                 230                 235                 240 


Ala Leu Leu Arg Lys Thr Val Gly Glu Thr Trp Gly Leu Pro Ser Pro 
                245                 250                 255     


Glu Glu Ala Ala Ala Ala Glu Ala Glu Val Phe Ala Thr Arg Tyr Ser 
            260                 265                 270         


Asp Asp Ser Pro Ala Pro Asp Asp Glu Ser Asp Pro Trp Met Thr Glu 
        275                 280                 285             


Asn Leu Thr Val Gln Pro Glu Arg Leu Gly Val Leu Ala Ser His His 
    290                 295                 300                 


Asp Asn Ala Ala Val Asp Ala Ser Ser Gly Val Glu Ala Ala Ala Gly 
305                 310                 315                 320 


Leu Gly Glu Ser Val Ala Ile Thr His Gly Pro Tyr Ser Ser Gln Phe 
                325                 330                 335     


Asn Asp Thr Leu Asn Met Ser Thr Thr Phe Ala Ala Arg Leu Asn Arg 
            340                 345                 350         


Leu Phe Asp Thr Val Tyr Pro Pro Gly Arg Gly Pro His Thr Ser Ala 
        355                 360                 365             


Glu Val Ile Ala Ala Leu Lys Ala Glu Gly Ile Thr Met Ser Ala Pro 
    370                 375                 380                 


Tyr Leu Ser Gln Leu Arg Ser Gly Asn Arg Thr Asn Pro Ser Gly Ala 
385                 390                 395                 400 


Thr Met Ala Ala Leu Ala Asn Phe Phe Arg Ile Lys Ala Ala Tyr Phe 
                405                 410                 415     


Thr Asp Asp Glu Tyr Tyr Glu Lys Leu Asp Lys Glu Leu Gln Trp Leu 
            420                 425                 430         


Ser Thr Met Arg Asp Asp Gly Val Arg Arg Ile Ala Gln Arg Ala His 
        435                 440                 445             


Gly Leu Pro Ser Ala Ala Gln Gln Lys Val Leu Asp Arg Ile Asp Glu 
    450                 455                 460                 


Leu Arg Arg Ala Glu Gly Ile Asp Ala Met Glu Lys Met Ser His Asp 
465                 470                 475                 480 


Pro Ile Ala Ala Asp Ile Gly Thr Gln Val Ser Asp Asn Ala Leu His 
                485                 490                 495     


Gly Val Thr Ala Gly Ser Thr Ala Leu Thr Ser Val Thr Gly Leu Val 
            500                 505                 510         


Pro Ala Gly Ala Asp Glu Val Ser Ala Gln Ala Ala Thr Ala Phe Thr 
        515                 520                 525             


Ser Glu Gly Ile Gln Leu Leu Ala Ser Asn Ala Ser Ala Gln Asp Gln 
    530                 535                 540                 


Leu His Arg Ala Gly Glu Ala Val Gln Asp Val Ala Arg Thr Tyr Ser 
545                 550                 555                 560 


Gln Ile Asp Asp Gly Ala Ala Gly Val Phe Ala Glu 
                565                 570         


<210>  15
<211>  56
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  15

Met Thr Glu Asn Leu Thr Val Gln Pro Glu Arg Leu Gly Val Leu Ala 
1               5                   10                  15      


Ser His His Asp Asn Ala Ala Val Asp Ala Ser Ser Gly Val Glu Ala 
            20                  25                  30          


Ala Ala Gly Leu Gly Glu Ser Val Ala Ile Thr His Gly Pro Tyr Ser 
        35                  40                  45              


Ser Gln Phe Asn Asp Thr Leu Asn 
    50                  55      


