                         SEQUENCE LISTING

<110>  University of Maryland, Office of Technology 
       Commercialization
       Children's National Medical Center
       Ayyub, Omar B.
       Heligman, Brian Theodore
       Kofinas, Peter
       Summar, Mashall L.
       Cunningham, Gary L.
       Cabrera-Luque, Juan M.
 
<120>  DEVICE AND METHODS OF USING DEVICE FOR DETECTION OF 
       AMINOACIDOPATHIES

<130>  140695.00802

<140>  PCT/US15/026546
<141>  2015-04-17

<150>  US 61/981,126
<151>  2014-04-17

<150>  US 62/112,019
<151>  2015-02-04

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  378
<212>  PRT
<213>  Geobacillus thermoglucosidiasius

<400>  1

Met Asn Thr Val Thr Asn Gln Trp Lys Ala Val Asp Ile Phe Thr Gln 
1               5                   10                  15      


Ile Arg Asp His Glu Gln Val Val Phe Cys Asn Asp Lys Asn Thr Gly 
            20                  25                  30          


Leu Lys Ala Ile Ile Ala Ile His Asp Thr Thr Leu Gly Pro Ala Leu 
        35                  40                  45              


Gly Gly Cys Arg Met Tyr Pro Tyr Ala Thr Val Glu Asp Ala Leu Phe 
    50                  55                  60                  


Asp Val Leu Arg Leu Ser Lys Gly Met Thr Tyr Lys Cys Leu Ala Ala 
65                  70                  75                  80  


Asp Val Asp Phe Gly Gly Gly Lys Ala Val Ile Ile Gly Asp Pro His 
                85                  90                  95      


Lys Asp Lys Thr Pro Glu Leu Phe Arg Ala Phe Gly Gln Phe Val Glu 
            100                 105                 110         


Ser Leu Asn Gly Arg Phe Tyr Thr Gly Thr Asp Met Gly Thr Thr Pro 
        115                 120                 125             


Asp Asp Phe Val His Ala Met Lys Glu Thr Asn Cys Ile Val Gly Val 
    130                 135                 140                 


Pro Glu Glu Tyr Gly Gly Ser Gly Asp Ser Ser Val Pro Thr Ala Leu 
145                 150                 155                 160 


Gly Val Ile Tyr Gly Ile Gln Ala Thr Asn Lys Val Ile Trp Gly Ser 
                165                 170                 175     


Asp Glu Leu His Gly Lys Thr Tyr Ala Ile Gln Gly Leu Gly Lys Val 
            180                 185                 190         


Gly Arg Lys Val Ala Glu Arg Leu Leu Lys Glu Gly Ala Asp Leu Tyr 
        195                 200                 205             


Val Cys Asp Ile His Pro Thr Ala Ile Glu Ala Ile Val Ser Tyr Ala 
    210                 215                 220                 


Lys Lys Leu Gly Ala Asn Val Lys Val Val Gln Gly Thr Glu Ile Tyr 
225                 230                 235                 240 


Arg Thr Asp Ala Asp Ile Phe Val Pro Cys Ala Phe Gly Asn Val Val 
                245                 250                 255     


Asn Asp Asn Thr Ile His Val Leu Lys Val Lys Ala Ile Val Gly Ser 
            260                 265                 270         


Ala Asn Asn Gln Leu Leu Asp Val Arg His Gly Gln Leu Leu Lys Glu 
        275                 280                 285             


Lys Gly Ile Leu Tyr Ala Pro Asp Tyr Ile Val Asn Ala Gly Gly Leu 
    290                 295                 300                 


Ile Gln Val Ala Asp Glu Leu Tyr Gly Leu Asn Lys Glu Arg Val Leu 
305                 310                 315                 320 


Gln Lys Thr Lys Ala Ile Tyr Ser Thr Leu Leu His Ile Tyr Ser Arg 
                325                 330                 335     


Ala Glu Ala Asp His Ile Thr Thr Ile Glu Ala Ala Asn Arg Phe Cys 
            340                 345                 350         


Glu Glu Arg Leu Gln Gln Arg Ser Arg Arg Asn Asp Phe Phe Thr His 
        355                 360                 365             


Arg Lys Gln Pro Lys Trp Asp Ile Arg Arg 
    370                 375             


<210>  2
<211>  366
<212>  PRT
<213>  Thermoactinomyces intermedius

<400>  2

Met Arg Asp Val Phe Glu Met Met Asp Arg Tyr Gly His Glu Gln Val 
1               5                   10                  15      


Ile Phe Cys Arg His Pro Gln Thr Gly Leu Lys Ala Ile Ile Ala Leu 
            20                  25                  30          


His Asn Thr Thr Ala Gly Pro Ala Leu Gly Gly Cys Arg Met Ile Pro 
        35                  40                  45              


Tyr Ala Ser Thr Asp Glu Ala Leu Glu Asp Val Leu Arg Leu Ser Lys 
    50                  55                  60                  


Gly Met Thr Tyr Lys Cys Ser Leu Ala Asp Val Asp Phe Gly Gly Gly 
65                  70                  75                  80  


Lys Met Val Ile Ile Gly Asp Pro Lys Lys Asp Lys Ser Pro Glu Leu 
                85                  90                  95      


Phe Arg Val Ile Gly Arg Phe Val Gly Gly Leu Asn Gly Arg Phe Tyr 
            100                 105                 110         


Thr Gly Thr Asp Met Gly Thr Asn Pro Glu Asp Phe Val His Ala Ala 
        115                 120                 125             


Arg Glu Ser Lys Ser Phe Ala Gly Leu Pro Lys Ser Tyr Gly Gly Lys 
    130                 135                 140                 


Gly Asp Thr Ser Ile Pro Thr Ala Leu Gly Val Phe His Gly Met Arg 
145                 150                 155                 160 


Ala Thr Ala Arg Phe Leu Trp Gly Thr Asp Gln Leu Lys Gly Arg Val 
                165                 170                 175     


Val Ala Ile Gln Gly Val Gly Lys Val Gly Glu Arg Leu Leu Gln Leu 
            180                 185                 190         


Leu Val Glu Val Gly Ala Tyr Cys Lys Ile Ala Asp Ile Asp Ser Val 
        195                 200                 205             


Arg Cys Glu Gln Leu Lys Glu Lys Tyr Gly Asp Lys Val Gln Leu Val 
    210                 215                 220                 


Asp Val Asn Arg Ile His Lys Glu Ser Cys Asp Ile Phe Ser Pro Cys 
225                 230                 235                 240 


Ala Lys Gly Gly Val Val Asn Asp Asp Thr Ile Asp Glu Phe Arg Cys 
                245                 250                 255     


Leu Ala Ile Val Gly Ser Ala Asn Asn Gln Leu Val Glu Asp Arg His 
            260                 265                 270         


Gly Ala Leu Leu Gln Lys Arg Ser Ile Cys Tyr Ala Pro Asp Tyr Leu 
        275                 280                 285             


Val Asn Ala Gly Gly Leu Ile Gln Val Ala Asp Glu Leu Glu Gly Phe 
    290                 295                 300                 


His Glu Glu Arg Val Leu Ala Lys Thr Glu Ala Ile Tyr Asp Met Val 
305                 310                 315                 320 


Leu Asp Ile Phe His Arg Ala Lys Asn Glu Asn Ile Thr Thr Cys Glu 
                325                 330                 335     


Ala Ala Asp Arg Ile Val Met Glu Arg Leu Lys Lys Leu Thr Asp Ile 
            340                 345                 350         


Arg Arg Ile Leu Leu Glu Asp Pro Arg Asn Ser Ala Arg Arg 
        355                 360                 365     


<210>  3
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' Primer for PheDH

<400>  3
tgtgctagca tgaataccgt taccaatcag tggaaagc                               38


<210>  4
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' primer for PheDH

<400>  4
ctcgagtcat taccggcgga tatcccactt cg                                     32


<210>  5
<211>  5236
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pET24a Vector Sequence

<400>  5
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagtgcggcc gcaagcttgt      180

cgacggagct cgaattcgga tcctagaggg gaattgttat ccgctcacaa ttcccctata      240

gtgagtcgta ttaatttcgc gggatcgaga tctcgatcct ctacgccgga cgcatcgtgg      300

ccggcatcac cggcgccaca ggtgcggttg ctggcgccta tatcgccgac atcaccgatg      360

gggaagatcg ggctcgccac ttcgggctca tgagcgcttg tttcggcgtg ggtatggtgg      420

caggccccgt ggccggggga ctgttgggcg ccatctcctt gcatgcacca ttccttgcgg      480

cggcggtgct caacggcctc aacctactac tgggctgctt cctaatgcag gagtcgcata      540

agggagagcg tcgagatccc ggacaccatc gaatggcgca aaacctttcg cggtatggca      600

tgatagcgcc cggaagagag tcaattcagg gtggtgaatg tgaaaccagt aacgttatac      660

gatgtcgcag agtatgccgg tgtctcttat cagaccgttt cccgcgtggt gaaccaggcc      720

agccacgttt ctgcgaaaac gcgggaaaaa gtggaagcgg cgatggcgga gctgaattac      780

attcccaacc gcgtggcaca acaactggcg ggcaaacagt cgttgctgat tggcgttgcc      840

acctccagtc tggccctgca cgcgccgtcg caaattgtcg cggcgattaa atctcgcgcc      900

gatcaactgg gtgccagcgt ggtggtgtcg atggtagaac gaagcggcgt cgaagcctgt      960

aaagcggcgg tgcacaatct tctcgcgcaa cgcgtcagtg ggctgatcat taactatccg     1020

ctggatgacc aggatgccat tgctgtggaa gctgcctgca ctaatgttcc ggcgttattt     1080

cttgatgtct ctgaccagac acccatcaac agtattattt tctcccatga agacggtacg     1140

cgactgggcg tggagcatct ggtcgcattg ggtcaccagc aaatcgcgct gttagcgggc     1200

ccattaagtt ctgtctcggc gcgtctgcgt ctggctggct ggcataaata tctcactcgc     1260

aatcaaattc agccgatagc ggaacgggaa ggcgactgga gtgccatgtc cggttttcaa     1320

caaaccatgc aaatgctgaa tgagggcatc gttcccactg cgatgctggt tgccaacgat     1380

cagatggcgc tgggcgcaat gcgcgccatt accgagtccg ggctgcgcgt tggtgcggat     1440

atctcggtag tgggatacga cgataccgaa gacagctcat gttatatccc gccgttaacc     1500

accatcaaac aggattttcg cctgctgggg caaaccagcg tggaccgctt gctgcaactc     1560

tctcagggcc aggcggtgaa gggcaatcag ctgttgcccg tctcactggt gaaaagaaaa     1620

accaccctgg cgcccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg     1680

cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt     1740

aagttagctc actcattagg caccgggatc tcgaccgatg cccttgagag ccttcaaccc     1800

agtcagctcc ttccggtggg cgcggggcat gactatcgtc gccgcactta tgactgtctt     1860

ctttatcatg caactcgtag gacaggtgcc ggcagcgctc tgggtcattt tcggcgagga     1920

ccgctttcgc tggagcgcga cgatgatcgg cctgtcgctt gcggtattcg gaatcttgca     1980

cgccctcgct caagccttcg tcactggtcc cgccaccaaa cgtttcggcg agaagcaggc     2040

cattatcgcc ggcatggcgg ccccacgggt gcgcatgatc gtgctcctgt cgttgaggac     2100

ccggctaggc tggcggggtt gccttactgg ttagcagaat gaatcaccga tacgcgagcg     2160

aacgtgaagc gactgctgct gcaaaacgtc tgcgacctga gcaacaacat gaatggtctt     2220

cggtttccgt gtttcgtaaa gtctggaaac gcggaagtca gcgccctgca ccattatgtt     2280

ccggatctgc atcgcaggat gctgctggct accctgtgga acacctacat ctgtattaac     2340

gaagcgctgg cattgaccct gagtgatttt tctctggtcc cgccgcatcc ataccgccag     2400

ttgtttaccc tcacaacgtt ccagtaaccg ggcatgttca tcatcagtaa cccgtatcgt     2460

gagcatcctc tctcgtttca tcggtatcat tacccccatg aacagaaatc ccccttacac     2520

ggaggcatca gtgaccaaac aggaaaaaac cgcccttaac atggcccgct ttatcagaag     2580

ccagacatta acgcttctgg agaaactcaa cgagctggac gcggatgaac aggcagacat     2640

ctgtgaatcg cttcacgacc acgctgatga gctttaccgc agctgcctcg cgcgtttcgg     2700

tgatgacggt gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta     2760

agcggatgcc gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg     2820

gggcgcagcc atgacccagt cacgtagcga tagcggagtg tatactggct taactatgcg     2880

gcatcagagc agattgtact gagagtgcac catatatgcg gtgtgaaata ccgcacagat     2940

gcgtaaggag aaaataccgc atcaggcgct cttccgcttc ctcgctcact gactcgctgc     3000

gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta atacggttat     3060

ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag caaaaggcca     3120

ggaaccgtaa aaaggccgcg ttgctggcgt ttttccatag gctccgcccc cctgacgagc     3180

atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta taaagatacc     3240

aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg     3300

gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc tcacgctgta     3360

ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg     3420

ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac ccggtaagac     3480

acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg aggtatgtag     3540

gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga aggacagtat     3600

ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt agctcttgat     3660

ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag cagattacgc     3720

gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct gacgctcagt     3780

ggaacgaaaa ctcacgttaa gggattttgg tcatgaacaa taaaactgtc tgcttacata     3840

aacagtaata caaggggtgt tatgagccat attcaacggg aaacgtcttg ctctaggccg     3900

cgattaaatt ccaacatgga tgctgattta tatgggtata aatgggctcg cgataatgtc     3960

gggcaatcag gtgcgacaat ctatcgattg tatgggaagc ccgatgcgcc agagttgttt     4020

ctgaaacatg gcaaaggtag cgttgccaat gatgttacag atgagatggt cagactaaac     4080

tggctgacgg aatttatgcc tcttccgacc atcaagcatt ttatccgtac tcctgatgat     4140

gcatggttac tcaccactgc gatccccggg aaaacagcat tccaggtatt agaagaatat     4200

cctgattcag gtgaaaatat tgttgatgcg ctggcagtgt tcctgcgccg gttgcattcg     4260

attcctgttt gtaattgtcc ttttaacagc gatcgcgtat ttcgtctcgc tcaggcgcaa     4320

tcacgaatga ataacggttt ggttgatgcg agtgattttg atgacgagcg taatggctgg     4380

cctgttgaac aagtctggaa agaaatgcat aaacttttgc cattctcacc ggattcagtc     4440

gtcactcatg gtgatttctc acttgataac cttatttttg acgaggggaa attaataggt     4500

tgtattgatg ttggacgagt cggaatcgca gaccgatacc aggatcttgc catcctatgg     4560

aactgcctcg gtgagttttc tccttcatta cagaaacggc tttttcaaaa atatggtatt     4620

gataatcctg atatgaataa attgcagttt catttgatgc tcgatgagtt tttctaagaa     4680

ttaattcatg agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc     4740

gcgcacattt ccccgaaaag tgccacctga aattgtaaac gttaatattt tgttaaaatt     4800

cgcgttaaat ttttgttaaa tcagctcatt ttttaaccaa taggccgaaa tcggcaaaat     4860

cccttataaa tcaaaagaat agaccgagat agggttgagt gttgttccag tttggaacaa     4920

gagtccacta ttaaagaacg tggactccaa cgtcaaaggg cgaaaaaccg tctatcaggg     4980

cgatggccca ctacgtgaac catcacccta atcaagtttt ttggggtcga ggtgccgtaa     5040

agcactaaat cggaacccta aagggagccc ccgatttaga gcttgacggg gaaagccggc     5100

gaacgtggcg agaaaggaag ggaagaaagc gaaaggagcg ggcgctaggg cgctggcaag     5160

tgtagcggtc acgctgcgcg taaccaccac acccgccgcg cttaatgcgc cgctacaggg     5220

cgcgtcccat tcgcca                                                     5236


<210>  6
<211>  5368
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pET28a vector sequence

<400>  6
atccggatat agttcctcct ttcagcaaaa aacccctcaa gacccgttta gaggccccaa       60

ggggttatgc tagttattgc tcagcggtgg cagcagccaa ctcagcttcc tttcgggctt      120

tgttagcagc cggatctcag tggtggtggt ggtggtgctc gagtgcggcc gcaagcttgt      180

cgacggagct cgaattcgga tccgcgaccc atttgctgtc caccagtcat gctagccata      240

tggctgccgc gcggcaccag gccgctgctg tgatgatgat gatgatggct gctgcccatg      300

gtatatctcc ttcttaaagt taaacaaaat tatttctaga ggggaattgt tatccgctca      360

caattcccct atagtgagtc gtattaattt cgcgggatcg agatctcgat cctctacgcc      420

ggacgcatcg tggccggcat caccggcgcc acaggtgcgg ttgctggcgc ctatatcgcc      480

gacatcaccg atggggaaga tcgggctcgc cacttcgggc tcatgagcgc ttgtttcggc      540

gtgggtatgg tggcaggccc cgtggccggg ggactgttgg gcgccatctc cttgcatgca      600

ccattccttg cggcggcggt gctcaacggc ctcaacctac tactgggctg cttcctaatg      660

caggagtcgc ataagggaga gcgtcgagat cccggacacc atcgaatggc gcaaaacctt      720

tcgcggtatg gcatgatagc gcccggaaga gagtcaattc agggtggtga atgtgaaacc      780

agtaacgtta tacgatgtcg cagagtatgc cggtgtctct tatcagaccg tttcccgcgt      840

ggtgaaccag gccagccacg tttctgcgaa aacgcgggaa aaagtggaag cggcgatggc      900

ggagctgaat tacattccca accgcgtggc acaacaactg gcgggcaaac agtcgttgct      960

gattggcgtt gccacctcca gtctggccct gcacgcgccg tcgcaaattg tcgcggcgat     1020

taaatctcgc gccgatcaac tgggtgccag cgtggtggtg tcgatggtag aacgaagcgg     1080

cgtcgaagcc tgtaaagcgg cggtgcacaa tcttctcgcg caacgcgtca gtgggctgat     1140

cattaactat ccgctggatg accaggatgc cattgctgtg gaagctgcct gcactaatgt     1200

tccggcgtta tttcttgatg tctctgacca gacacccatc aacagtatta ttttctccca     1260

tgaagacggt acgcgactgg gcgtggagca tctggtcgca ttgggtcacc agcaaatcgc     1320

gctgttagcg ggcccattaa gttctgtctc ggcgcgtctg cgtctggctg gctggcataa     1380

atatctcact cgcaatcaaa ttcagccgat agcggaacgg gaaggcgact ggagtgccat     1440

gtccggtttt caacaaacca tgcaaatgct gaatgagggc atcgttccca ctgcgatgct     1500

ggttgccaac gatcagatgg cgctgggcgc aatgcgcgcc attaccgagt ccgggctgcg     1560

cgttggtgcg gatatctcgg tagtgggata cgacgatacc gaagacagct catgttatat     1620

cccgccgtta accaccatca aacaggattt tcgcctgctg gggcaaacca gcgtggaccg     1680

cttgctgcaa ctctctcagg gccaggcggt gaagggcaat cagctgttgc ccgtctcact     1740

ggtgaaaaga aaaaccaccc tggcgcccaa tacgcaaacc gcctctcccc gcgcgttggc     1800

cgattcatta atgcagctgg cacgacaggt ttcccgactg gaaagcgggc agtgagcgca     1860

acgcaattaa tgtaagttag ctcactcatt aggcaccggg atctcgaccg atgcccttga     1920

gagccttcaa cccagtcagc tccttccggt gggcgcgggg catgactatc gtcgccgcac     1980

ttatgactgt cttctttatc atgcaactcg taggacaggt gccggcagcg ctctgggtca     2040

ttttcggcga ggaccgcttt cgctggagcg cgacgatgat cggcctgtcg cttgcggtat     2100

tcggaatctt gcacgccctc gctcaagcct tcgtcactgg tcccgccacc aaacgtttcg     2160

gcgagaagca ggccattatc gccggcatgg cggccccacg ggtgcgcatg atcgtgctcc     2220

tgtcgttgag gacccggcta ggctggcggg gttgccttac tggttagcag aatgaatcac     2280

cgatacgcga gcgaacgtga agcgactgct gctgcaaaac gtctgcgacc tgagcaacaa     2340

catgaatggt cttcggtttc cgtgtttcgt aaagtctgga aacgcggaag tcagcgccct     2400

gcaccattat gttccggatc tgcatcgcag gatgctgctg gctaccctgt ggaacaccta     2460

catctgtatt aacgaagcgc tggcattgac cctgagtgat ttttctctgg tcccgccgca     2520

tccataccgc cagttgttta ccctcacaac gttccagtaa ccgggcatgt tcatcatcag     2580

taacccgtat cgtgagcatc ctctctcgtt tcatcggtat cattaccccc atgaacagaa     2640

atccccctta cacggaggca tcagtgacca aacaggaaaa aaccgccctt aacatggccc     2700

gctttatcag aagccagaca ttaacgcttc tggagaaact caacgagctg gacgcggatg     2760

aacaggcaga catctgtgaa tcgcttcacg accacgctga tgagctttac cgcagctgcc     2820

tcgcgcgttt cggtgatgac ggtgaaaacc tctgacacat gcagctcccg gagacggtca     2880

cagcttgtct gtaagcggat gccgggagca gacaagcccg tcagggcgcg tcagcgggtg     2940

ttggcgggtg tcggggcgca gccatgaccc agtcacgtag cgatagcgga gtgtatactg     3000

gcttaactat gcggcatcag agcagattgt actgagagtg caccatatat gcggtgtgaa     3060

ataccgcaca gatgcgtaag gagaaaatac cgcatcaggc gctcttccgc ttcctcgctc     3120

actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg     3180

gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc     3240

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc     3300

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     3360

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     3420

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     3480

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     3540

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     3600

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     3660

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     3720

agaaggacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     3780

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag     3840

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg     3900

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgaa caataaaact     3960

gtctgcttac ataaacagta atacaagggg tgttatgagc catattcaac gggaaacgtc     4020

ttgctctagg ccgcgattaa attccaacat ggatgctgat ttatatgggt ataaatgggc     4080

tcgcgataat gtcgggcaat caggtgcgac aatctatcga ttgtatggga agcccgatgc     4140

gccagagttg tttctgaaac atggcaaagg tagcgttgcc aatgatgtta cagatgagat     4200

ggtcagacta aactggctga cggaatttat gcctcttccg accatcaagc attttatccg     4260

tactcctgat gatgcatggt tactcaccac tgcgatcccc gggaaaacag cattccaggt     4320

attagaagaa tatcctgatt caggtgaaaa tattgttgat gcgctggcag tgttcctgcg     4380

ccggttgcat tcgattcctg tttgtaattg tccttttaac agcgatcgcg tatttcgtct     4440

cgctcaggcg caatcacgaa tgaataacgg tttggttgat gcgagtgatt ttgatgacga     4500

gcgtaatggc tggcctgttg aacaagtctg gaaagaaatg cataaacttt tgccattctc     4560

accggattca gtcgtcactc atggtgattt ctcacttgat aaccttattt ttgacgaggg     4620

gaaattaata ggttgtattg atgttggacg agtcggaatc gcagaccgat accaggatct     4680

tgccatccta tggaactgcc tcggtgagtt ttctccttca ttacagaaac ggctttttca     4740

aaaatatggt attgataatc ctgatatgaa taaattgcag tttcatttga tgctcgatga     4800

gtttttctaa gaattaattc atgagcggat acatatttga atgtatttag aaaaataaac     4860

aaataggggt tccgcgcaca tttccccgaa aagtgccacc taaattgtaa gcgttaatat     4920

tttgttaaaa ttcgcgttaa atttttgtta aatcagctca ttttttaacc aataggccga     4980

aatcggcaaa atcccttata aatcaaaaga atagaccgag atagggttga gtgttgttcc     5040

agtttggaac aagagtccac tattaaagaa cgtggactcc aacgtcaaag ggcgaaaaac     5100

cgtctatcag ggcgatggcc cactacgtga accatcaccc taatcaagtt ttttggggtc     5160

gaggtgccgt aaagcactaa atcggaaccc taaagggagc ccccgattta gagcttgacg     5220

gggaaagccg gcgaacgtgg cgagaaagga agggaagaaa gcgaaaggag cgggcgctag     5280

ggcgctggca agtgtagcgg tcacgctgcg cgtaaccacc acacccgccg cgcttaatgc     5340

gccgctacag ggcgcgtccc attcgcca                                        5368


<210>  7
<211>  721
<212>  PRT
<213>  Solanum lycopersicum

<400>  7

Met Ala Ser Ser Ile Val Gln Asn Gly His Val Asn Gly Glu Ala Met 
1               5                   10                  15      


Asp Leu Cys Lys Lys Ser Ile Asn Val Asn Asp Pro Leu Asn Trp Glu 
            20                  25                  30          


Met Ala Ala Glu Ser Leu Arg Gly Ser His Leu Asp Glu Val Lys Lys 
        35                  40                  45              


Met Val Asp Glu Phe Arg Lys Pro Ile Val Lys Leu Gly Gly Glu Thr 
    50                  55                  60                  


Leu Thr Val Ala Gln Val Ala Ser Ile Ala Asn Val Asp Asn Lys Ser 
65                  70                  75                  80  


Asn Gly Val Lys Val Glu Leu Ser Glu Ser Ala Arg Ala Gly Val Lys 
                85                  90                  95      


Ala Ser Ser Asp Trp Val Met Asp Ser Met Gly Lys Gly Thr Asp Ser 
            100                 105                 110         


Tyr Gly Val Thr Thr Gly Phe Gly Ala Thr Ser His Arg Arg Thr Lys 
        115                 120                 125             


Asn Gly Gly Ala Leu Gln Lys Glu Leu Ile Arg Phe Leu Asn Ala Gly 
    130                 135                 140                 


Val Phe Gly Asn Gly Thr Glu Ser Ser His Thr Leu Pro His Ser Ala 
145                 150                 155                 160 


Thr Arg Ala Ala Met Leu Val Arg Ile Asn Thr Leu Leu Gln Gly Tyr 
                165                 170                 175     


Ser Gly Ile Arg Phe Glu Ile Leu Glu Ala Ile Thr Lys Leu Ile Asn 
            180                 185                 190         


Ser Asn Ile Thr Pro Cys Leu Pro Leu Arg Gly Thr Ile Thr Ala Ser 
        195                 200                 205             


Gly Asp Leu Val Pro Leu Ser Tyr Ile Ala Gly Leu Leu Thr Gly Arg 
    210                 215                 220                 


Pro Asn Ser Lys Ala Val Gly Pro Asn Gly Glu Lys Leu Asn Ala Glu 
225                 230                 235                 240 


Glu Ala Phe Arg Val Ala Gly Val Thr Ser Gly Phe Phe Glu Leu Gln 
                245                 250                 255     


Pro Lys Glu Gly Leu Ala Leu Val Asn Gly Thr Ala Val Gly Ser Gly 
            260                 265                 270         


Met Ala Ser Met Val Leu Phe Glu Ser Asn Ile Leu Ala Val Met Ser 
        275                 280                 285             


Glu Val Leu Ser Ala Ile Phe Ala Glu Val Met Asn Gly Lys Pro Glu 
    290                 295                 300                 


Phe Thr Asp Tyr Leu Thr His Lys Leu Lys His His Pro Gly Gln Ile 
305                 310                 315                 320 


Glu Ala Ala Ala Ile Met Glu His Ile Leu Asp Gly Ser Ser Tyr Val 
                325                 330                 335     


Lys Ala Ala Gln Lys Leu His Glu Met Asp Pro Leu Gln Lys Pro Lys 
            340                 345                 350         


Gln Asp Arg Tyr Ala Leu Arg Thr Ser Pro Gln Trp Leu Gly Pro Gln 
        355                 360                 365             


Ile Glu Val Ile Arg Ala Ala Thr Lys Met Ile Glu Arg Glu Ile Asn 
    370                 375                 380                 


Ser Val Asn Asp Asn Pro Leu Ile Asp Val Ser Arg Asn Lys Ala Leu 
385                 390                 395                 400 


His Gly Gly Asn Phe Gln Gly Thr Pro Ile Gly Val Ser Met Asp Asn 
                405                 410                 415     


Thr Arg Leu Ala Leu Ala Ser Ile Gly Lys Leu Met Phe Ala Gln Phe 
            420                 425                 430         


Ser Glu Leu Val Asn Asp Tyr Tyr Asn Asn Gly Leu Pro Ser Asn Leu 
        435                 440                 445             


Thr Ala Gly Arg Asn Pro Ser Leu Asp Tyr Gly Leu Lys Gly Ala Glu 
    450                 455                 460                 


Ile Ala Met Ala Ser Tyr Cys Ser Glu Leu Gln Phe Leu Ala Asn Pro 
465                 470                 475                 480 


Val Thr Asn His Val Gln Ser Ala Glu Gln His Asn Gln Asp Val Asn 
                485                 490                 495     


Ser Leu Gly Leu Ile Ser Ala Arg Lys Thr Ala Glu Ala Val Asp Ile 
            500                 505                 510         


Leu Lys Leu Met Ser Ser Thr Tyr Leu Val Ala Leu Cys Gln Ala Ile 
        515                 520                 525             


Asp Leu Arg His Leu Glu Glu Asn Leu Arg Ser Ala Val Lys Asn Thr 
    530                 535                 540                 


Val Ser Gln Val Ala Lys Arg Thr Leu Thr Met Gly Ala Asn Gly Glu 
545                 550                 555                 560 


Leu His Pro Ala Arg Phe Cys Glu Lys Glu Leu Leu Arg Val Val Asp 
                565                 570                 575     


Arg Glu Tyr Val Phe Ala Tyr Ala Asp Asp Pro Cys Ser Ser Thr Tyr 
            580                 585                 590         


Pro Leu Met Gln Lys Leu Arg Gln Val Leu Val Asp His Ala Met Lys 
        595                 600                 605             


Asn Gly Glu Ser Glu Lys Asn Val Asn Ser Ser Ile Phe Gln Lys Ile 
    610                 615                 620                 


Val Ala Phe Glu Asp Glu Leu Lys Ala Val Leu Pro Lys Glu Val Glu 
625                 630                 635                 640 


Ser Ala Arg Ala Val Val Glu Ser Gly Asn Pro Ala Ile Pro Asn Arg 
                645                 650                 655     


Ile Thr Glu Cys Arg Ser Tyr Pro Leu Tyr Arg Leu Val Arg Gln Glu 
            660                 665                 670         


Leu Gly Ser Glu Leu Leu Thr Gly Glu Lys Val Arg Ser Pro Gly Glu 
        675                 680                 685             


Glu Ile Asp Lys Val Phe Thr Ala Met Cys Asn Gly Gln Ile Ile Asp 
    690                 695                 700                 


Pro Leu Leu Glu Cys Leu Lys Ser Trp Asn Gly Ala Pro Leu Pro Ile 
705                 710                 715                 720 


Cys 
    


<210>  8
<211>  1101
<212>  DNA
<213>  Thermoactinomyces intermedius

<400>  8
atgcgcgacg tgtttgaaat gatggaccgc tatggccacg agcaggtcat tttttgccgt       60

catccgcaaa ccggtctcaa agcgatcatc gccttgcata atacaaccgc ggggccggct      120

ttgggtggat gccgcatgat cccgtatgct tcgacggacg aagccttgga ggatgttttg      180

cggttgtcca aaggcatgac ctataaatgc agtctggcgg atgtggactt tggcggggga      240

aaaatggtta tcatcggcga tccgaaaaaa gataaatcgc cggagttgtt tcgcgtgatc      300

ggccgttttg tgggcgggtt aaacggccgt ttctataccg gaaccgacat gggaaccaat      360

ccggaagatt ttgtccatgc cgccagggaa tcgaaatctt ttgccggatt gccgaaatcg      420

tacggcggaa agggggacac atccattccc accgcgctcg gggtgtttca cggaatgcgg      480

gccaccgccc ggtttttatg ggggacggat cagctgaaag ggcgtgtggt tgccatccaa      540

ggagtcggca aggtgggaga gcgcttgttg cagcttttgg tcgaagtggg ggcttactgc      600

aaaattgccg acatcgattc ggtgcgatgc gaacagctga aagaaaagta tggcgacaag      660

gtccaattgg tggatgtgaa ccggattcac aaggagagtt gcgatatttt ctcgccttgc      720

gccaaaggcg gcgtggtcaa tgatgacacc attgacgagt tccgttgcct ggccattgtc      780

ggatccgcca acaaccaact ggtggaagac cggcatgggg cactgcttca aaaacggagc      840

atttgttatg cacccgatta tctggtgaat gccggcgggc tgattcaagt ggctgatgaa      900

ctggaaggct tccatgaaga gagagtgctc gccaaaaccg aagcgattta tgacatggtc      960

ctggatattt ttcaccgggc gaaaaatgag aatattacca cttgtgaggc agcggaccgg     1020

atcgtgatgg agcgtttgaa aaagttaacc gatattcgcc ggatcttgtt ggaggatccc     1080

cgcaacagcg caaggaggta a                                               1101


<210>  9
<211>  352
<212>  PRT
<213>  Caenorhabditis remanei

<400>  9

Met Asp Phe Lys Ala Lys Leu Leu Ala Glu Met Ala Lys Lys Arg Lys 
1               5                   10                  15      


Ala Val Ser Gly Leu Glu Val Lys Glu Gly Gly Ala Lys Phe Val Arg 
            20                  25                  30          


Gly Ala Asp Leu Glu Ser Lys Arg Thr Gln Glu Tyr Glu Ala Lys Gln 
        35                  40                  45              


Glu Glu Leu Ala Ile Lys Lys Arg Lys Ala Asp Asp Glu Ile Leu Gln 
    50                  55                  60                  


Glu Ser Thr Ser Arg Ala Lys Ile Val Pro Glu Val Pro Glu Ala Glu 
65                  70                  75                  80  


Phe Asp Glu Lys Thr Pro Met Pro Glu Ile His Ala Arg Leu Arg Gln 
                85                  90                  95      


Arg Gly Gln Pro Ile Leu Leu Phe Gly Glu Ser Glu Leu Ser Val Arg 
            100                 105                 110         


Lys Arg Leu His Gln Leu Glu Ile Glu Gln Pro Glu Leu Asn Glu Gly 
        115                 120                 125             


Trp Glu Asn Glu Met Gln Thr Ala Met Lys Phe Ile Gly Lys Glu Met 
    130                 135                 140                 


Asp Lys Ala Val Val Glu Gly Thr Ala Asp Ser Ala Thr Arg His Asp 
145                 150                 155                 160 


Ile Ala Leu Pro Gln Gly Tyr Glu Glu Asp Asn Trp Lys Ser Ile Glu 
                165                 170                 175     


His Ala Ser Thr Leu Leu Gly Val Gly Asp Glu Met Lys Arg Asp Cys 
            180                 185                 190         


Asp Ile Ile Leu Ser Ile Cys Arg Tyr Ile Leu Ala Arg Trp Ala Arg 
        195                 200                 205             


Asp Leu Asn Asp Arg Pro Leu Asp Val Lys Lys Thr Ala Gln Gly Met 
    210                 215                 220                 


His Glu Ala Ala His His Lys Gln Thr Thr Met His Leu Lys Ser Leu 
225                 230                 235                 240 


Met Thr Ser Met Glu Lys Tyr Asn Val Asn Asn Asp Ile Arg His His 
                245                 250                 255     


Leu Ala Lys Ile Cys Arg Leu Leu Val Ile Glu Arg Asn Tyr Leu Glu 
            260                 265                 270         


Ala Asn Asn Ala Tyr Met Glu Met Ala Ile Gly Asn Ala Pro Trp Pro 
        275                 280                 285             


Val Gly Val Thr Arg Ser Gly Ile His Gln Arg Pro Gly Ser Ala Lys 
    290                 295                 300                 


Ala Tyr Val Ser Asn Ile Ala His Val Leu Asn Asp Glu Thr Gln Arg 
305                 310                 315                 320 


Lys Tyr Ile Gln Ala Phe Lys Arg Leu Met Thr Lys Leu Gln Glu Tyr 
                325                 330                 335     


Phe Pro Thr Asp Pro Ser Lys Ser Val Glu Phe Val Lys Lys Ser Val 
            340                 345                 350         


<210>  10
<211>  411
<212>  PRT
<213>  Arabidopsis thaliana

<400>  10

Met Asn Ala Leu Ala Ala Thr Asn Arg Asn Phe Lys Leu Ala Ala Arg 
1               5                   10                  15      


Leu Leu Gly Leu Asp Ser Lys Leu Glu Lys Ser Leu Leu Ile Pro Phe 
            20                  25                  30          


Arg Glu Ile Lys Val Glu Cys Thr Ile Pro Lys Asp Asp Gly Thr Leu 
        35                  40                  45              


Ala Ser Phe Val Gly Phe Arg Val Gln His Asp Asn Ala Arg Gly Pro 
    50                  55                  60                  


Met Lys Gly Gly Ile Arg Tyr His Pro Glu Val Asp Pro Asp Glu Val 
65                  70                  75                  80  


Asn Ala Leu Ala Gln Leu Met Thr Trp Lys Thr Ala Val Ala Lys Ile 
                85                  90                  95      


Pro Tyr Gly Gly Ala Lys Gly Gly Ile Gly Cys Asp Pro Ser Lys Leu 
            100                 105                 110         


Ser Ile Ser Glu Leu Glu Arg Leu Thr Arg Val Phe Thr Gln Lys Ile 
        115                 120                 125             


His Asp Leu Ile Gly Ile His Thr Asp Val Pro Ala Pro Asp Met Gly 
    130                 135                 140                 


Thr Gly Pro Gln Thr Met Ala Trp Ile Leu Asp Glu Tyr Ser Lys Phe 
145                 150                 155                 160 


His Gly Tyr Ser Pro Ala Val Val Thr Gly Lys Pro Ile Asp Leu Gly 
                165                 170                 175     


Gly Ser Leu Gly Arg Asp Ala Ala Thr Gly Arg Gly Val Met Phe Gly 
            180                 185                 190         


Thr Glu Ala Leu Leu Asn Glu His Gly Lys Thr Ile Ser Gly Gln Arg 
        195                 200                 205             


Phe Val Ile Gln Gly Phe Gly Asn Val Gly Ser Trp Ala Ala Lys Leu 
    210                 215                 220                 


Ile Ser Glu Lys Gly Gly Lys Ile Val Ala Val Ser Asp Ile Thr Gly 
225                 230                 235                 240 


Ala Ile Lys Asn Lys Asp Gly Ile Asp Ile Pro Ala Leu Leu Lys His 
                245                 250                 255     


Thr Lys Glu His Arg Gly Val Lys Gly Phe Asp Gly Ala Asp Pro Ile 
            260                 265                 270         


Asp Pro Asn Ser Ile Leu Val Glu Asp Cys Asp Ile Leu Val Pro Ala 
        275                 280                 285             


Ala Leu Gly Gly Val Ile Asn Arg Glu Asn Ala Asn Glu Ile Lys Ala 
    290                 295                 300                 


Lys Phe Ile Ile Glu Ala Ala Asn His Pro Thr Asp Pro Asp Ala Asp 
305                 310                 315                 320 


Glu Ile Leu Ser Lys Lys Gly Val Val Ile Leu Pro Asp Ile Tyr Ala 
                325                 330                 335     


Asn Ser Gly Gly Val Thr Val Ser Tyr Phe Glu Trp Val Gln Asn Ile 
            340                 345                 350         


Gln Gly Phe Met Trp Glu Glu Glu Lys Val Asn Asp Glu Leu Lys Thr 
        355                 360                 365             


Tyr Met Thr Arg Ser Phe Lys Asp Leu Lys Glu Met Cys Lys Thr His 
    370                 375                 380                 


Ser Cys Asp Leu Arg Met Gly Ala Phe Thr Leu Gly Val Asn Arg Val 
385                 390                 395                 400 


Ala Gln Ala Thr Ile Leu Arg Gly Trp Gly Ala 
                405                 410     


