                         SEQUENCE LISTING

<110>  University of Virginia Patent Foundation
       Zarling, Angela L
       Engelhard, Victor H
       Cummings, Kara
       Obeng, Rebecca
 
<120>  ISOLATED T CELL RECEPTORS AND METHODS OF USE THEREFOR

<130>  3062/9 PCT

<150>  US 61/979,854
<151>  2014-04-15

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  1338
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ser Pro Pro Arg His Gly Pro Pro Gly Pro Ala Ser Gly Asp 
1               5                   10                  15      


Gly Pro Asn Leu Asn Asn Asn Asn Asn Asn Asn Asn His Ser Val Arg 
            20                  25                  30          


Lys Cys Gly Tyr Leu Arg Lys Gln Lys His Gly His Lys Arg Phe Phe 
        35                  40                  45              


Val Leu Arg Gly Pro Gly Ala Gly Gly Asp Glu Ala Thr Ala Gly Gly 
    50                  55                  60                  


Gly Ser Ala Pro Gln Pro Pro Arg Leu Glu Tyr Tyr Glu Ser Glu Lys 
65                  70                  75                  80  


Lys Trp Arg Ser Lys Ala Gly Ala Pro Lys Arg Val Ile Ala Leu Asp 
                85                  90                  95      


Cys Cys Leu Asn Ile Asn Lys Arg Ala Asp Ala Lys His Lys Tyr Leu 
            100                 105                 110         


Ile Ala Leu Tyr Thr Lys Asp Glu Tyr Phe Ala Val Ala Ala Glu Asn 
        115                 120                 125             


Glu Gln Glu Gln Glu Gly Trp Tyr Arg Ala Leu Thr Asp Leu Val Ser 
    130                 135                 140                 


Glu Gly Arg Ala Ala Ala Gly Asp Ala Pro Pro Ala Ala Ala Pro Ala 
145                 150                 155                 160 


Ala Ser Cys Ser Ala Ser Leu Pro Gly Ala Leu Gly Gly Ser Ala Gly 
                165                 170                 175     


Ala Ala Gly Ala Glu Asp Ser Tyr Gly Leu Val Ala Pro Ala Thr Ala 
            180                 185                 190         


Ala Tyr Arg Glu Val Trp Gln Val Asn Leu Lys Pro Lys Gly Leu Gly 
        195                 200                 205             


Gln Ser Lys Asn Leu Thr Gly Val Tyr Arg Leu Cys Leu Ser Ala Arg 
    210                 215                 220                 


Thr Ile Gly Phe Val Lys Leu Asn Cys Glu Gln Pro Ser Val Thr Leu 
225                 230                 235                 240 


Gln Leu Met Asn Ile Arg Arg Cys Gly His Ser Asp Ser Phe Phe Phe 
                245                 250                 255     


Ile Glu Val Gly Arg Ser Ala Val Thr Gly Pro Gly Glu Leu Trp Met 
            260                 265                 270         


Gln Ala Asp Asp Ser Val Val Ala Gln Asn Ile His Glu Thr Ile Leu 
        275                 280                 285             


Glu Ala Met Lys Ala Leu Lys Glu Leu Phe Glu Phe Arg Pro Arg Ser 
    290                 295                 300                 


Lys Ser Gln Ser Ser Gly Ser Ser Ala Thr His Pro Ile Ser Val Pro 
305                 310                 315                 320 


Gly Ala Arg Arg His His His Leu Val Asn Leu Pro Pro Ser Gln Thr 
                325                 330                 335     


Gly Leu Val Arg Arg Ser Arg Thr Asp Ser Leu Ala Ala Thr Pro Pro 
            340                 345                 350         


Ala Ala Lys Cys Ser Ser Cys Arg Val Arg Thr Ala Ser Glu Gly Asp 
        355                 360                 365             


Gly Gly Ala Ala Ala Gly Ala Ala Ala Ala Gly Ala Arg Pro Val Ser 
    370                 375                 380                 


Val Ala Gly Ser Pro Leu Ser Pro Gly Pro Val Arg Ala Pro Leu Ser 
385                 390                 395                 400 


Arg Ser His Thr Leu Ser Gly Gly Cys Gly Gly Arg Gly Ser Lys Val 
                405                 410                 415     


Ala Leu Leu Pro Ala Gly Gly Ala Leu Gln His Ser Arg Ser Met Ser 
            420                 425                 430         


Met Pro Val Ala His Ser Pro Pro Ala Ala Thr Ser Pro Gly Ser Leu 
        435                 440                 445             


Ser Ser Ser Ser Gly His Gly Ser Gly Ser Tyr Pro Pro Pro Pro Gly 
    450                 455                 460                 


Pro His Pro Pro Leu Pro His Pro Leu His His Gly Pro Gly Gln Arg 
465                 470                 475                 480 


Pro Ser Ser Gly Ser Ala Ser Ala Ser Gly Ser Pro Ser Asp Pro Gly 
                485                 490                 495     


Phe Met Ser Leu Asp Glu Tyr Gly Ser Ser Pro Gly Asp Leu Arg Ala 
            500                 505                 510         


Phe Cys Ser His Arg Ser Asn Thr Pro Glu Ser Ile Ala Glu Thr Pro 
        515                 520                 525             


Pro Ala Arg Asp Gly Gly Gly Gly Gly Glu Phe Tyr Gly Tyr Met Thr 
    530                 535                 540                 


Met Asp Arg Pro Leu Ser His Cys Gly Arg Ser Tyr Arg Arg Val Ser 
545                 550                 555                 560 


Gly Asp Ala Ala Gln Asp Leu Asp Arg Gly Leu Arg Lys Arg Thr Tyr 
                565                 570                 575     


Ser Leu Thr Thr Pro Ala Arg Gln Arg Pro Val Pro Gln Pro Ser Ser 
            580                 585                 590         


Ala Ser Leu Asp Glu Tyr Thr Leu Met Arg Ala Thr Phe Ser Gly Ser 
        595                 600                 605             


Ala Gly Arg Leu Cys Pro Ser Cys Pro Ala Ser Ser Pro Lys Val Ala 
    610                 615                 620                 


Tyr His Pro Tyr Pro Glu Asp Tyr Gly Asp Ile Glu Ile Gly Ser His 
625                 630                 635                 640 


Arg Ser Ser Ser Ser Asn Leu Gly Ala Asp Asp Gly Tyr Met Pro Met 
                645                 650                 655     


Thr Pro Gly Ala Ala Leu Ala Gly Ser Gly Ser Gly Ser Cys Arg Ser 
            660                 665                 670         


Asp Asp Tyr Met Pro Met Ser Pro Ala Ser Val Ser Ala Pro Lys Gln 
        675                 680                 685             


Ile Leu Gln Pro Arg Ala Ala Ala Ala Ala Ala Ala Ala Val Pro Ser 
    690                 695                 700                 


Ala Gly Pro Ala Gly Pro Ala Pro Thr Ser Ala Ala Gly Arg Thr Phe 
705                 710                 715                 720 


Pro Ala Ser Gly Gly Gly Tyr Lys Ala Ser Ser Pro Ala Glu Ser Ser 
                725                 730                 735     


Pro Glu Asp Ser Gly Tyr Met Arg Met Trp Cys Gly Ser Lys Leu Ser 
            740                 745                 750         


Met Glu His Ala Asp Gly Lys Leu Leu Pro Asn Gly Asp Tyr Leu Asn 
        755                 760                 765             


Val Ser Pro Ser Asp Ala Val Thr Thr Gly Thr Pro Pro Asp Phe Phe 
    770                 775                 780                 


Ser Ala Ala Leu His Pro Gly Gly Glu Pro Leu Arg Gly Val Pro Gly 
785                 790                 795                 800 


Cys Cys Tyr Ser Ser Leu Pro Arg Ser Tyr Lys Ala Pro Tyr Thr Cys 
                805                 810                 815     


Gly Gly Asp Ser Asp Gln Tyr Val Leu Met Ser Ser Pro Val Gly Arg 
            820                 825                 830         


Ile Leu Glu Glu Glu Arg Leu Glu Pro Gln Ala Thr Pro Gly Pro Ser 
        835                 840                 845             


Gln Ala Ala Ser Ala Phe Gly Ala Gly Pro Thr Gln Pro Pro His Pro 
    850                 855                 860                 


Val Val Pro Ser Pro Val Arg Pro Ser Gly Gly Arg Pro Glu Gly Phe 
865                 870                 875                 880 


Leu Gly Gln Arg Gly Arg Ala Val Arg Pro Thr Arg Leu Ser Leu Glu 
                885                 890                 895     


Gly Leu Pro Ser Leu Pro Ser Met His Glu Tyr Pro Leu Pro Pro Glu 
            900                 905                 910         


Pro Lys Ser Pro Gly Glu Tyr Ile Asn Ile Asp Phe Gly Glu Pro Gly 
        915                 920                 925             


Ala Arg Leu Ser Pro Pro Ala Pro Pro Leu Leu Ala Ser Ala Ala Ser 
    930                 935                 940                 


Ser Ser Ser Leu Leu Ser Ala Ser Ser Pro Ala Ser Ser Leu Gly Ser 
945                 950                 955                 960 


Gly Thr Pro Gly Thr Ser Ser Asp Ser Arg Gln Arg Ser Pro Leu Ser 
                965                 970                 975     


Asp Tyr Met Asn Leu Asp Phe Ser Ser Pro Lys Ser Pro Lys Pro Gly 
            980                 985                 990         


Ala Pro Ser Gly His Pro Val Gly  Ser Leu Asp Gly Leu  Leu Ser Pro 
        995                 1000                 1005             


Glu Ala  Ser Ser Pro Tyr Pro  Pro Leu Pro Pro Arg  Pro Ser Ala 
    1010                 1015                 1020             


Ser Pro  Ser Ser Ser Leu Gln  Pro Pro Pro Pro Pro  Pro Ala Pro 
    1025                 1030                 1035             


Gly Glu  Leu Tyr Arg Leu Pro  Pro Ala Ser Ala Val  Ala Thr Ala 
    1040                 1045                 1050             


Gln Gly  Pro Gly Ala Ala Ser  Ser Leu Ser Ser Asp  Thr Gly Asp 
    1055                 1060                 1065             


Asn Gly  Asp Tyr Thr Glu Met  Ala Phe Gly Val Ala  Ala Thr Pro 
    1070                 1075                 1080             


Pro Gln  Pro Ile Ala Ala Pro  Pro Lys Pro Glu Ala  Ala Arg Val 
    1085                 1090                 1095             


Ala Ser  Pro Thr Ser Gly Val  Lys Arg Leu Ser Leu  Met Glu Gln 
    1100                 1105                 1110             


Val Ser  Gly Val Glu Ala Phe  Leu Gln Ala Ser Gln  Pro Pro Asp 
    1115                 1120                 1125             


Pro His  Arg Gly Ala Lys Val  Ile Arg Ala Asp Pro  Gln Gly Gly 
    1130                 1135                 1140             


Arg Arg  Arg His Ser Ser Glu  Thr Phe Ser Ser Thr  Thr Thr Val 
    1145                 1150                 1155             


Thr Pro  Val Ser Pro Ser Phe  Ala His Asn Pro Lys  Arg His Asn 
    1160                 1165                 1170             


Ser Ala  Ser Val Glu Asn Val  Ser Leu Arg Lys Ser  Ser Glu Gly 
    1175                 1180                 1185             


Gly Val  Gly Val Gly Pro Gly  Gly Gly Asp Glu Pro  Pro Thr Ser 
    1190                 1195                 1200             


Pro Arg  Gln Leu Gln Pro Ala  Pro Pro Leu Ala Pro  Gln Gly Arg 
    1205                 1210                 1215             


Pro Trp  Thr Pro Gly Gln Pro  Gly Gly Leu Val Gly  Cys Pro Gly 
    1220                 1225                 1230             


Ser Gly  Gly Ser Pro Met Arg  Arg Glu Thr Ser Ala  Gly Phe Gln 
    1235                 1240                 1245             


Asn Gly  Leu Asn Tyr Ile Ala  Ile Asp Val Arg Glu  Glu Pro Gly 
    1250                 1255                 1260             


Leu Pro  Pro Gln Pro Gln Pro  Pro Pro Pro Pro Leu  Pro Gln Pro 
    1265                 1270                 1275             


Gly Asp  Lys Ser Ser Trp Gly  Arg Thr Arg Ser Leu  Gly Gly Leu 
    1280                 1285                 1290             


Ile Ser  Ala Val Gly Val Gly  Ser Thr Gly Gly Gly  Cys Gly Gly 
    1295                 1300                 1305             


Pro Gly  Pro Gly Ala Leu Pro  Pro Ala Asn Thr Tyr  Ala Ser Ile 
    1310                 1315                 1320             


Asp Phe  Leu Ser His His Leu  Lys Glu Ala Thr Ile  Val Lys Glu 
    1325                 1330                 1335             


<210>  2
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Val Ala Ser Pro Thr Ser Gly Val 
1               5                   


<210>  3
<211>  807
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(807)

<400>  3
atg ctc ctg gca ctc ctc cca gtg ctg ggg ata cac ttt gtc ctg aga         48
Met Leu Leu Ala Leu Leu Pro Val Leu Gly Ile His Phe Val Leu Arg           
1               5                   10                  15                

gat gcc caa gct cag tca gtg aca cag ccc gat gct cgc gtc act gtc         96
Asp Ala Gln Ala Gln Ser Val Thr Gln Pro Asp Ala Arg Val Thr Val           
            20                  25                  30                    

tct gaa gga gcc tct ctg cag ctg aga tgc aag tat tcc tac tct ggg        144
Ser Glu Gly Ala Ser Leu Gln Leu Arg Cys Lys Tyr Ser Tyr Ser Gly           
        35                  40                  45                        

acg cct tat ctg ttc tgg tat gtc cag tac ccg cgg cag ggg ctg cag        192
Thr Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Arg Gln Gly Leu Gln           
    50                  55                  60                            

ctg ctc ctc aag tac tat tcc gga gac cca gtg gtt caa gga gtg aat        240
Leu Leu Leu Lys Tyr Tyr Ser Gly Asp Pro Val Val Gln Gly Val Asn           
65                  70                  75                  80            

ggc ttt gag gct gag ttc atc aag agt aac tct tcc ttc cac ctg cgg        288
Gly Phe Glu Ala Glu Phe Ile Lys Ser Asn Ser Ser Phe His Leu Arg           
                85                  90                  95                

aaa gcc tct gtg cac tgg agc gac tcg gct gtg tac ttc tgt gct gtg        336
Lys Ala Ser Val His Trp Ser Asp Ser Ala Val Tyr Phe Cys Ala Val           
            100                 105                 110                   

agc gaa ggt gca gat aga ctc acc ttt ggg aaa gga act cag ctg atc        384
Ser Glu Gly Ala Asp Arg Leu Thr Phe Gly Lys Gly Thr Gln Leu Ile           
        115                 120                 125                       

atc cag ccc tac atc cag aac cca gaa cct gct gtg tac cag tta aaa        432
Ile Gln Pro Tyr Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys           
    130                 135                 140                           

gat cct cgg tct cag gac agc acc ctc tgc ctg ttc acc gac ttt gac        480
Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp           
145                 150                 155                 160           

tcc caa atc aat gtg ccg aaa acc atg gaa tct gga acg ctc atc act        528
Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Leu Ile Thr           
                165                 170                 175               

gac aaa act gtg ctg gac atg aaa gct atg gat tcc aag agc aat ggg        576
Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly           
            180                 185                 190                   

gcc att gcc tgg agc aac cag aca agc ttc acc tgc caa gat atc ttc        624
Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe           
        195                 200                 205                       

aaa gag acc aac gcc acc tac ccc agt tca gac gtt ccc tgt gat gcc        672
Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala           
    210                 215                 220                           

acg ttg act gag aaa agc ttt gaa aca gat atg aac cta aac ttt caa        720
Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln           
225                 230                 235                 240           

aac ctg tca gtt atg gga ctc cga atc ctc ctg ctg aaa gta gcc gga        768
Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly           
                245                 250                 255               

ttt aac ctg ctc atg acg ctg agg ctg tgg tcc agt taa                    807
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser                           
            260                 265                                       


<210>  4
<211>  268
<212>  PRT
<213>  Mus musculus

<400>  4

Met Leu Leu Ala Leu Leu Pro Val Leu Gly Ile His Phe Val Leu Arg 
1               5                   10                  15      


Asp Ala Gln Ala Gln Ser Val Thr Gln Pro Asp Ala Arg Val Thr Val 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Gln Leu Arg Cys Lys Tyr Ser Tyr Ser Gly 
        35                  40                  45              


Thr Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Arg Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Tyr Ser Gly Asp Pro Val Val Gln Gly Val Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Ile Lys Ser Asn Ser Ser Phe His Leu Arg 
                85                  90                  95      


Lys Ala Ser Val His Trp Ser Asp Ser Ala Val Tyr Phe Cys Ala Val 
            100                 105                 110         


Ser Glu Gly Ala Asp Arg Leu Thr Phe Gly Lys Gly Thr Gln Leu Ile 
        115                 120                 125             


Ile Gln Pro Tyr Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Leu Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  5
<211>  921
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(921)

<400>  5
atg ggc acc agg ctt ctt ggc tgg gca gtg ttc tgt ctc ctt gac aca         48
Met Gly Thr Arg Leu Leu Gly Trp Ala Val Phe Cys Leu Leu Asp Thr           
1               5                   10                  15                

gta ctg tct gaa gct gga gtc acc cag tct ccc aga tat gca gtc cta         96
Val Leu Ser Glu Ala Gly Val Thr Gln Ser Pro Arg Tyr Ala Val Leu           
            20                  25                  30                    

cag gaa ggg caa gct gtt tcc ttt tgg tgt gac cct att tct gga cat        144
Gln Glu Gly Gln Ala Val Ser Phe Trp Cys Asp Pro Ile Ser Gly His           
        35                  40                  45                        

gat acc ctt tac tgg tat cag cag ccc aga gac cag ggg ccc cag ctt        192
Asp Thr Leu Tyr Trp Tyr Gln Gln Pro Arg Asp Gln Gly Pro Gln Leu           
    50                  55                  60                            

cta gtt tac ttt cgg gat gag gct gtt ata gat aat tca cag ttg ccc        240
Leu Val Tyr Phe Arg Asp Glu Ala Val Ile Asp Asn Ser Gln Leu Pro           
65                  70                  75                  80            

tcg gat cga ttt tct gct gtg agg cct aaa gga act aac tcc act ctc        288
Ser Asp Arg Phe Ser Ala Val Arg Pro Lys Gly Thr Asn Ser Thr Leu           
                85                  90                  95                

aag atc cag tct gca aag cag ggc gac aca gcc acc tat ctc tgt gcc        336
Lys Ile Gln Ser Ala Lys Gln Gly Asp Thr Ala Thr Tyr Leu Cys Ala           
            100                 105                 110                   

agc agt tta ttg gac agc tcc tat gaa cag tac ttc ggt ccc ggc acc        384
Ser Ser Leu Leu Asp Ser Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr           
        115                 120                 125                       

agg ctc acg gtt tta gag gat ctg aga aat gtg act cca ccc aag gtc        432
Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val           
    130                 135                 140                           

tcc ttg ttt gag cca tca aaa gca gag att gca aac aaa caa aag gct        480
Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala           
145                 150                 155                 160           

acc ctc gtg tgc ttg gcc agg ggc ttc ttc cct gac cac gtg gag ctg        528
Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu           
                165                 170                 175               

agc tgg tgg gtg aat ggc aag gag gtc cac agt ggg gtc agc acg gac        576
Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp           
            180                 185                 190                   

cct cag gcc tac aag gag agc aat tat agc tac tgc ctg agc agc cgc        624
Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg           
        195                 200                 205                       

ctg agg gtc tct gct acc ttc tgg cac aat cct cga aac cac ttc cgc        672
Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg           
    210                 215                 220                           

tgc caa gtg cag ttc cat ggg ctt tca gag gag gac aag tgg cca gag        720
Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu           
225                 230                 235                 240           

ggc tca ccc aaa cct gtc aca cag aac atc agt gca gag gcc tgg ggc        768
Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly           
                245                 250                 255               

cga gca gac tgt gga atc act tca gca tcc tat cat cag ggg gtt ctg        816
Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu           
            260                 265                 270                   

tct gca acc atc ctc tat gag atc cta ctg ggg aag gcc acc cta tat        864
Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr           
        275                 280                 285                       

gct gtg ctg gtc agt ggc ctg gtg ctg atg gcc atg gtc aag aaa aaa        912
Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys           
    290                 295                 300                           

aat tcc tag                                                            921
Asn Ser                                                                   
305                                                                       


<210>  6
<211>  306
<212>  PRT
<213>  Mus musculus

<400>  6

Met Gly Thr Arg Leu Leu Gly Trp Ala Val Phe Cys Leu Leu Asp Thr 
1               5                   10                  15      


Val Leu Ser Glu Ala Gly Val Thr Gln Ser Pro Arg Tyr Ala Val Leu 
            20                  25                  30          


Gln Glu Gly Gln Ala Val Ser Phe Trp Cys Asp Pro Ile Ser Gly His 
        35                  40                  45              


Asp Thr Leu Tyr Trp Tyr Gln Gln Pro Arg Asp Gln Gly Pro Gln Leu 
    50                  55                  60                  


Leu Val Tyr Phe Arg Asp Glu Ala Val Ile Asp Asn Ser Gln Leu Pro 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Val Arg Pro Lys Gly Thr Asn Ser Thr Leu 
                85                  90                  95      


Lys Ile Gln Ser Ala Lys Gln Gly Asp Thr Ala Thr Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Leu Leu Asp Ser Ser Tyr Glu Gln Tyr Phe Gly Pro Gly Thr 
        115                 120                 125             


Arg Leu Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val 
    130                 135                 140                 


Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala 
145                 150                 155                 160 


Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu 
                165                 170                 175     


Ser Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp 
            180                 185                 190         


Pro Gln Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg 
        195                 200                 205             


Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg 
    210                 215                 220                 


Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu 
225                 230                 235                 240 


Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly 
                245                 250                 255     


Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu 
            260                 265                 270         


Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr 
        275                 280                 285             


Ala Val Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys 
    290                 295                 300                 


Asn Ser 
305     


<210>  7
<211>  810
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(810)

<400>  7
atg ctc ctg gca ctc ctc cca gtg ctg ggg ata cac ttt gtc ctg aga         48
Met Leu Leu Ala Leu Leu Pro Val Leu Gly Ile His Phe Val Leu Arg           
1               5                   10                  15                

gat gcc caa gct cag tca gtg aca cag ccc gat gct cgc gtc act gtc         96
Asp Ala Gln Ala Gln Ser Val Thr Gln Pro Asp Ala Arg Val Thr Val           
            20                  25                  30                    

tct gaa gga gcc tct ctg cag ctg aga tgc aag tat tcc tac tct ggg        144
Ser Glu Gly Ala Ser Leu Gln Leu Arg Cys Lys Tyr Ser Tyr Ser Gly           
        35                  40                  45                        

acg cct tat ctg ttc tgg tat gtc cag tac ccg cgg cag ggg ctg cag        192
Thr Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Arg Gln Gly Leu Gln           
    50                  55                  60                            

ctg ctc ctc aag tac tat tcc gga gac cca gtg gtt caa gga gtg aat        240
Leu Leu Leu Lys Tyr Tyr Ser Gly Asp Pro Val Val Gln Gly Val Asn           
65                  70                  75                  80            

ggc ttt gag gct gag ttc atc aag agt aac tct tcc ttc cac ctg cgg        288
Gly Phe Glu Ala Glu Phe Ile Lys Ser Asn Ser Ser Phe His Leu Arg           
                85                  90                  95                

aaa gcc tct gtg cac tgg agc gac tcg gct gtg tac ttc tgt gct gtg        336
Lys Ala Ser Val His Trp Ser Asp Ser Ala Val Tyr Phe Cys Ala Val           
            100                 105                 110                   

agc gct ggc agt ggt gga aaa ctc act ttg ggg gct gga aca aga ctt        384
Ser Ala Gly Ser Gly Gly Lys Leu Thr Leu Gly Ala Gly Thr Arg Leu           
        115                 120                 125                       

cag gtc aac ctt gac atc cag aac cca gaa cct gct gtg tac cag tta        432
Gln Val Asn Leu Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu           
    130                 135                 140                           

aaa gat cct cgg tct cag gac agc acc ctc tgc ctg ttc acc gac ttt        480
Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe           
145                 150                 155                 160           

gac tcc caa gtc aat gtg ccg aaa acc atg gaa tct gga acg ttc atc        528
Asp Ser Gln Val Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile           
                165                 170                 175               

gct gac aaa act gtg ctg gac atg aaa gct atg gat tcc aag agc aat        576
Ala Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn           
            180                 185                 190                   

ggg gcc att gcc tgg agc aac cag aca agc ttc acc tgc caa gat atc        624
Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile           
        195                 200                 205                       

ttc aaa gag acc aac gcc acc tac ccc agt tca gac gtt ccc tgt gat        672
Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp           
    210                 215                 220                           

gcc acg ttg act gag aaa agc ttt gaa aca gat atg aac cta aac ttt        720
Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe           
225                 230                 235                 240           

caa aac ctg tca gtt atg gga ctc cga atc ctc ctg ctg aaa gta gcc        768
Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala           
                245                 250                 255               

gga ttt aac ctg ctc atg acg ctg agg ctg tgg tcc agt taa                810
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser                       
            260                 265                                       


<210>  8
<211>  269
<212>  PRT
<213>  Mus musculus

<400>  8

Met Leu Leu Ala Leu Leu Pro Val Leu Gly Ile His Phe Val Leu Arg 
1               5                   10                  15      


Asp Ala Gln Ala Gln Ser Val Thr Gln Pro Asp Ala Arg Val Thr Val 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Gln Leu Arg Cys Lys Tyr Ser Tyr Ser Gly 
        35                  40                  45              


Thr Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Arg Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Tyr Ser Gly Asp Pro Val Val Gln Gly Val Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Ile Lys Ser Asn Ser Ser Phe His Leu Arg 
                85                  90                  95      


Lys Ala Ser Val His Trp Ser Asp Ser Ala Val Tyr Phe Cys Ala Val 
            100                 105                 110         


Ser Ala Gly Ser Gly Gly Lys Leu Thr Leu Gly Ala Gly Thr Arg Leu 
        115                 120                 125             


Gln Val Asn Leu Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Val Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Ala Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 


<210>  9
<211>  915
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(915)

<400>  9
atg ggc tcc aga ctc ttc ttt gtg gtt ttg att ctc ctg tgt gca aaa         48
Met Gly Ser Arg Leu Phe Phe Val Val Leu Ile Leu Leu Cys Ala Lys           
1               5                   10                  15                

cac atg gag gct gca gtc acc caa agt cca aga agc aag gtg gca gta         96
His Met Glu Ala Ala Val Thr Gln Ser Pro Arg Ser Lys Val Ala Val           
            20                  25                  30                    

aca gga gga aag gtg aca ttg agc tgt cac cag gct aat aac cat gac        144
Thr Gly Gly Lys Val Thr Leu Ser Cys His Gln Ala Asn Asn His Asp           
        35                  40                  45                        

tat atg tac tgg tat cgg cag gac acg ggg cat ggg ctg agg ctg atc        192
Tyr Met Tyr Trp Tyr Arg Gln Asp Thr Gly His Gly Leu Arg Leu Ile           
    50                  55                  60                            

cat tac tca tat gtc gct gac agc acg gag aaa gga gat atc cct gat        240
His Tyr Ser Tyr Val Ala Asp Ser Thr Glu Lys Gly Asp Ile Pro Asp           
65                  70                  75                  80            

ggg tac aag gcc tcc aga cca agc caa gag aat ttc tct ctc att ctg        288
Gly Tyr Lys Ala Ser Arg Pro Ser Gln Glu Asn Phe Ser Leu Ile Leu           
                85                  90                  95                

gag ttg gct tcc ctt tct cag aca gct gta tat ttc tgt gcc agc agt        336
Glu Leu Ala Ser Leu Ser Gln Thr Ala Val Tyr Phe Cys Ala Ser Ser           
            100                 105                 110                   

gat agg gac aac tat gct gag cag ttc ttc gga cca ggg aca cga ctc        384
Asp Arg Asp Asn Tyr Ala Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu           
        115                 120                 125                       

acc gtc cta gag gat ctg aga aat gtg act cca ccc aag gtc tcc ttg        432
Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu           
    130                 135                 140                           

ttt gag cca tca aaa gca gag att gca aac aaa caa aag gct acc ctc        480
Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu           
145                 150                 155                 160           

gtg tgc ttg gcc agg ggc ttc ttc cct gac cac gtg gag ctg agc tgg        528
Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp           
                165                 170                 175               

tgg gtg aat ggc aag gag gtc cgc agt ggg gtc agc acg gac cct cag        576
Trp Val Asn Gly Lys Glu Val Arg Ser Gly Val Ser Thr Asp Pro Gln           
            180                 185                 190                   

gcc tac aag gag agc aat tat agc tac tgc ctg agc agc cgc ctg agg        624
Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg           
        195                 200                 205                       

gtc tct gct acc ttc tgg cac aat cct cga aac cac ttc cgc tgc caa        672
Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln           
    210                 215                 220                           

gtg cag ttc cat ggg ctt tca gag gag gac aag tgg cca gag ggc tca        720
Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser           
225                 230                 235                 240           

ccc aaa cct gtc aca cag aac atc agt gca gag gcc tgg ggc cga gca        768
Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala           
                245                 250                 255               

gac tgt gga atc act tca gca tcc tat cat cag ggg gtt ctg tct gca        816
Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala           
            260                 265                 270                   

acc atc ctc tat gag atc cta ctg ggg aag gcc acc cta tac gct gtg        864
Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val           
        275                 280                 285                       

ctg gtc agt ggc ctg gtg ctg atg gcc atg gtc aag aaa aaa aat tcc        912
Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser           
    290                 295                 300                           

taa                                                                    915


<210>  10
<211>  304
<212>  PRT
<213>  Mus musculus

<400>  10

Met Gly Ser Arg Leu Phe Phe Val Val Leu Ile Leu Leu Cys Ala Lys 
1               5                   10                  15      


His Met Glu Ala Ala Val Thr Gln Ser Pro Arg Ser Lys Val Ala Val 
            20                  25                  30          


Thr Gly Gly Lys Val Thr Leu Ser Cys His Gln Ala Asn Asn His Asp 
        35                  40                  45              


Tyr Met Tyr Trp Tyr Arg Gln Asp Thr Gly His Gly Leu Arg Leu Ile 
    50                  55                  60                  


His Tyr Ser Tyr Val Ala Asp Ser Thr Glu Lys Gly Asp Ile Pro Asp 
65                  70                  75                  80  


Gly Tyr Lys Ala Ser Arg Pro Ser Gln Glu Asn Phe Ser Leu Ile Leu 
                85                  90                  95      


Glu Leu Ala Ser Leu Ser Gln Thr Ala Val Tyr Phe Cys Ala Ser Ser 
            100                 105                 110         


Asp Arg Asp Asn Tyr Ala Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu 
        115                 120                 125             


Thr Val Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu 
    130                 135                 140                 


Phe Glu Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu 
145                 150                 155                 160 


Val Cys Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp 
                165                 170                 175     


Trp Val Asn Gly Lys Glu Val Arg Ser Gly Val Ser Thr Asp Pro Gln 
            180                 185                 190         


Ala Tyr Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg 
        195                 200                 205             


Val Ser Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln 
    210                 215                 220                 


Val Gln Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser 
225                 230                 235                 240 


Pro Lys Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala 
                245                 250                 255     


Asp Cys Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala 
            260                 265                 270         


Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
        275                 280                 285             


Leu Val Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
    290                 295                 300                 


<210>  11
<211>  580
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Val Pro Gln Pro Glu Pro Ala Pro Gly Ser Ala Leu Ser Pro 
1               5                   10                  15      


Ala Gly Val Cys Gly Gly Ala Gln Arg Pro Gly His Leu Pro Gly Leu 
            20                  25                  30          


Leu Leu Gly Ser His Gly Leu Leu Gly Ser Pro Val Arg Ala Ala Ala 
        35                  40                  45              


Ser Ser Pro Val Thr Thr Leu Thr Gln Thr Met His Asp Leu Ala Gly 
    50                  55                  60                  


Leu Gly Ser Glu Thr Pro Lys Ser Gln Val Gly Thr Leu Leu Phe Arg 
65                  70                  75                  80  


Ser Arg Ser Arg Leu Thr His Leu Ser Leu Ser Arg Arg Ala Ser Glu 
                85                  90                  95      


Ser Ser Leu Ser Ser Glu Ser Ser Glu Ser Ser Asp Ala Gly Leu Cys 
            100                 105                 110         


Met Asp Ser Pro Ser Pro Met Asp Pro His Met Ala Glu Gln Thr Phe 
        115                 120                 125             


Glu Gln Ala Ile Gln Ala Ala Ser Arg Ile Ile Arg Asn Glu Gln Phe 
    130                 135                 140                 


Ala Ile Arg Arg Phe Gln Ser Met Pro Val Arg Leu Leu Gly His Ser 
145                 150                 155                 160 


Pro Val Leu Arg Asn Ile Thr Asn Ser Gln Ala Pro Asp Gly Arg Arg 
                165                 170                 175     


Lys Ser Glu Ala Gly Ser Gly Ala Ala Ser Ser Ser Gly Glu Asp Lys 
            180                 185                 190         


Glu Asn Asp Gly Phe Val Phe Lys Met Pro Trp Lys Pro Thr His Pro 
        195                 200                 205             


Ser Ser Thr His Ala Leu Ala Glu Trp Ala Ser Arg Arg Glu Ala Phe 
    210                 215                 220                 


Ala Gln Arg Pro Ser Ser Ala Pro Asp Leu Met Cys Leu Ser Pro Asp 
225                 230                 235                 240 


Arg Lys Met Glu Val Glu Glu Leu Ser Pro Leu Ala Leu Gly Arg Phe 
                245                 250                 255     


Ser Leu Thr Pro Ala Glu Gly Asp Thr Glu Glu Asp Asp Gly Phe Val 
            260                 265                 270         


Asp Ile Leu Glu Ser Asp Leu Lys Asp Asp Asp Ala Val Pro Pro Gly 
        275                 280                 285             


Met Glu Ser Leu Ile Ser Ala Pro Leu Val Lys Thr Leu Glu Lys Glu 
    290                 295                 300                 


Glu Glu Lys Asp Leu Val Met Tyr Ser Lys Cys Gln Arg Leu Phe Arg 
305                 310                 315                 320 


Ser Pro Ser Met Pro Cys Ser Val Ile Arg Pro Ile Leu Lys Arg Leu 
                325                 330                 335     


Glu Arg Pro Gln Asp Arg Asp Thr Pro Val Gln Asn Lys Arg Arg Arg 
            340                 345                 350         


Ser Val Thr Pro Pro Glu Glu Gln Gln Glu Ala Glu Glu Pro Lys Ala 
        355                 360                 365             


Arg Val Leu Arg Ser Lys Ser Leu Cys His Asp Glu Ile Glu Asn Leu 
    370                 375                 380                 


Leu Asp Ser Asp His Arg Glu Leu Ile Gly Asp Tyr Ser Lys Ala Phe 
385                 390                 395                 400 


Leu Leu Gln Thr Val Asp Gly Lys His Gln Asp Leu Lys Tyr Ile Ser 
                405                 410                 415     


Pro Glu Thr Met Val Ala Leu Leu Thr Gly Lys Phe Ser Asn Ile Val 
            420                 425                 430         


Asp Lys Phe Val Ile Val Asp Cys Arg Tyr Pro Tyr Glu Tyr Glu Gly 
        435                 440                 445             


Gly His Ile Lys Thr Ala Val Asn Leu Pro Leu Glu Arg Asp Ala Glu 
    450                 455                 460                 


Ser Phe Leu Leu Lys Ser Pro Ile Ala Pro Cys Ser Leu Asp Lys Arg 
465                 470                 475                 480 


Val Ile Leu Ile Phe His Cys Glu Phe Ser Ser Glu Arg Gly Pro Arg 
                485                 490                 495     


Met Cys Arg Phe Ile Arg Glu Arg Asp Arg Ala Val Asn Asp Tyr Pro 
            500                 505                 510         


Ser Leu Tyr Tyr Pro Glu Met Tyr Ile Leu Lys Gly Gly Tyr Lys Glu 
        515                 520                 525             


Phe Phe Pro Gln His Pro Asn Phe Cys Glu Pro Gln Asp Tyr Arg Pro 
    530                 535                 540                 


Met Asn His Glu Ala Phe Lys Asp Glu Leu Lys Thr Phe Arg Leu Lys 
545                 550                 555                 560 


Thr Arg Ser Trp Ala Gly Glu Arg Ser Arg Arg Glu Leu Cys Ser Arg 
                565                 570                 575     


Leu Gln Asp Gln 
            580 


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Gly Leu Leu Gly Ser Pro Val Arg Ala 
1               5                   


<210>  13
<211>  810
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(810)

<400>  13
atg aag aca gtg act gga cct ttg ttc ctg tgc ttc tgg ctg cag ctg         48
Met Lys Thr Val Thr Gly Pro Leu Phe Leu Cys Phe Trp Leu Gln Leu           
1               5                   10                  15                

aac tgt gtg agc aga ggc gag cag gtg gag cag cgc cct cct cac ctg         96
Asn Cys Val Ser Arg Gly Glu Gln Val Glu Gln Arg Pro Pro His Leu           
            20                  25                  30                    

agt gtc cgg gag gga gac agt gcc gtt atc atc tgc acc tac aca gac        144
Ser Val Arg Glu Gly Asp Ser Ala Val Ile Ile Cys Thr Tyr Thr Asp           
        35                  40                  45                        

cct aac agt tat tac ttc ttc tgg tac aag caa gag ccg ggg gca ggt        192
Pro Asn Ser Tyr Tyr Phe Phe Trp Tyr Lys Gln Glu Pro Gly Ala Gly           
    50                  55                  60                            

ctt cag ttg ctt atg aag gtt ttc tca agt acg gaa ata aac gaa ggg        240
Leu Gln Leu Leu Met Lys Val Phe Ser Ser Thr Glu Ile Asn Glu Gly           
65                  70                  75                  80            

caa gga ttc act gtc cta ctg aac aag aaa gac caa caa ctc tct ctg        288
Gln Gly Phe Thr Val Leu Leu Asn Lys Lys Asp Gln Gln Leu Ser Leu           
                85                  90                  95                

aac ctc aca gct gcc cat cct ggg gac tca gcc gtg tac ttc tgc gca        336
Asn Leu Thr Ala Ala His Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala           
            100                 105                 110                   

gtc aaa cct gga ggc tat aaa gtg gtc ttt gga agt ggg act cga ttg        384
Val Lys Pro Gly Gly Tyr Lys Val Val Phe Gly Ser Gly Thr Arg Leu           
        115                 120                 125                       

ctg gta agc cct gac atc cag aac cca gaa cct gct gtg tac cag tta        432
Leu Val Ser Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu           
    130                 135                 140                           

aaa gat cct cgg tct cag gac agc acc ctc tgc ctg ttc acc gac ttt        480
Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe           
145                 150                 155                 160           

gac tcc caa atc aat gtg ccg aaa acc atg gaa tct gga acg ttc atc        528
Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile           
                165                 170                 175               

act gac aaa act gtg ctg gac atg aaa gct atg gat tcc aag agc aat        576
Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn           
            180                 185                 190                   

ggg gcc att gcc tgg agc aac cag aca agc ttc acc tgc caa gat atc        624
Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile           
        195                 200                 205                       

ttc aaa gag acc aac gcc acc tac ccc agt tca gac gtt ccc tgt gat        672
Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp           
    210                 215                 220                           

gcc acg ttg aca gag aaa agc ttt gaa aca gat atg aac cta aac ttt        720
Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe           
225                 230                 235                 240           

caa aac ctg tca gtt atg gga ctc cga atc ctc ctg ctg aaa gta gcc        768
Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala           
                245                 250                 255               

gga ttt aac ctg ctc atg acg ctg agg ctg tgg tcc agt taa                810
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser                       
            260                 265                                       


<210>  14
<211>  269
<212>  PRT
<213>  Mus musculus

<400>  14

Met Lys Thr Val Thr Gly Pro Leu Phe Leu Cys Phe Trp Leu Gln Leu 
1               5                   10                  15      


Asn Cys Val Ser Arg Gly Glu Gln Val Glu Gln Arg Pro Pro His Leu 
            20                  25                  30          


Ser Val Arg Glu Gly Asp Ser Ala Val Ile Ile Cys Thr Tyr Thr Asp 
        35                  40                  45              


Pro Asn Ser Tyr Tyr Phe Phe Trp Tyr Lys Gln Glu Pro Gly Ala Gly 
    50                  55                  60                  


Leu Gln Leu Leu Met Lys Val Phe Ser Ser Thr Glu Ile Asn Glu Gly 
65                  70                  75                  80  


Gln Gly Phe Thr Val Leu Leu Asn Lys Lys Asp Gln Gln Leu Ser Leu 
                85                  90                  95      


Asn Leu Thr Ala Ala His Pro Gly Asp Ser Ala Val Tyr Phe Cys Ala 
            100                 105                 110         


Val Lys Pro Gly Gly Tyr Lys Val Val Phe Gly Ser Gly Thr Arg Leu 
        115                 120                 125             


Leu Val Ser Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 


<210>  15
<211>  936
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(936)

<400>  15
atg tct aac act gcc ttc cct gac ccc gcc tgg aac acc acc ctg cta         48
Met Ser Asn Thr Ala Phe Pro Asp Pro Ala Trp Asn Thr Thr Leu Leu           
1               5                   10                  15                

tct tgg gtt gct ctc ttt ctc ctg gga aca aaa cac atg gag gct gca         96
Ser Trp Val Ala Leu Phe Leu Leu Gly Thr Lys His Met Glu Ala Ala           
            20                  25                  30                    

gtc acc caa agc cca aga aac aag gtg gca gta aca gga gga aag gtg        144
Val Thr Gln Ser Pro Arg Asn Lys Val Ala Val Thr Gly Gly Lys Val           
        35                  40                  45                        

aca ttg agc tgt aat cag act aat aac cac aac aac atg tac tgg tat        192
Thr Leu Ser Cys Asn Gln Thr Asn Asn His Asn Asn Met Tyr Trp Tyr           
    50                  55                  60                            

cgg cag gac acg ggg cat ggg ctg agg ctg atc cat tat tca tat ggt        240
Arg Gln Asp Thr Gly His Gly Leu Arg Leu Ile His Tyr Ser Tyr Gly           
65                  70                  75                  80            

gct ggc agc act gag aaa gga gat atc cct gat gga tac aag gcc tcc        288
Ala Gly Ser Thr Glu Lys Gly Asp Ile Pro Asp Gly Tyr Lys Ala Ser           
                85                  90                  95                

aga cca agc caa gag aac ttc tcc ctc att ctg gag ttg gct acc ccc        336
Arg Pro Ser Gln Glu Asn Phe Ser Leu Ile Leu Glu Leu Ala Thr Pro           
            100                 105                 110                   

tct cag aca tca gtg tac ttc tgt gcc agc ggt ggc gac acc cag tac        384
Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Gly Gly Asp Thr Gln Tyr           
        115                 120                 125                       

ttt ggg cca ggc act cgg ctc ctc gtg tta gag gat ctg aga aat gtg        432
Phe Gly Pro Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Arg Asn Val           
    130                 135                 140                           

act cca ccc aag gtc tcc ttg ttt gag cca tca aaa gca gag att gca        480
Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala           
145                 150                 155                 160           

aac aaa caa aag gct acc ctc gtg tgc ttg gcc agg ggc ttc ttc cct        528
Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro           
                165                 170                 175               

gac cac gtg gag ctg agc tgg tgg gtg aat ggc aag gag gtc cac agt        576
Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser           
            180                 185                 190                   

ggg gtc agc acg gac cct cag gcc tac aag gag cgc aat tat agc tac        624
Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Arg Asn Tyr Ser Tyr           
        195                 200                 205                       

tgc ctg agc agc cgc ctg agg gtc tct gct acc ttc tgg cac aat cct        672
Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro           
    210                 215                 220                           

cga aac cac ttc cgc tgc caa gtg cag ttc cat ggg ctt tca gag gag        720
Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu           
225                 230                 235                 240           

gac aag tgg cca gag ggc tca ccc aaa cct gtc aca cag aac atc agt        768
Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser           
                245                 250                 255               

gca gag gcc tgg ggc cga gca gac tgt gga atc act tca gca tcc tat        816
Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr           
            260                 265                 270                   

cat cag ggg gtt ctg tct gca acc atc ctc tat gag atc cta ctg ggg        864
His Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly           
        275                 280                 285                       

aag gcc acc cta tat gct gtg ctg gtc agt ggc ctg gtg ctg atg gcc        912
Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Gly Leu Val Leu Met Ala           
    290                 295                 300                           

atg gtc aag aaa aaa aat tcc taa                                        936
Met Val Lys Lys Lys Asn Ser                                               
305                 310                                                   


<210>  16
<211>  311
<212>  PRT
<213>  Mus musculus

<400>  16

Met Ser Asn Thr Ala Phe Pro Asp Pro Ala Trp Asn Thr Thr Leu Leu 
1               5                   10                  15      


Ser Trp Val Ala Leu Phe Leu Leu Gly Thr Lys His Met Glu Ala Ala 
            20                  25                  30          


Val Thr Gln Ser Pro Arg Asn Lys Val Ala Val Thr Gly Gly Lys Val 
        35                  40                  45              


Thr Leu Ser Cys Asn Gln Thr Asn Asn His Asn Asn Met Tyr Trp Tyr 
    50                  55                  60                  


Arg Gln Asp Thr Gly His Gly Leu Arg Leu Ile His Tyr Ser Tyr Gly 
65                  70                  75                  80  


Ala Gly Ser Thr Glu Lys Gly Asp Ile Pro Asp Gly Tyr Lys Ala Ser 
                85                  90                  95      


Arg Pro Ser Gln Glu Asn Phe Ser Leu Ile Leu Glu Leu Ala Thr Pro 
            100                 105                 110         


Ser Gln Thr Ser Val Tyr Phe Cys Ala Ser Gly Gly Asp Thr Gln Tyr 
        115                 120                 125             


Phe Gly Pro Gly Thr Arg Leu Leu Val Leu Glu Asp Leu Arg Asn Val 
    130                 135                 140                 


Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu Ile Ala 
145                 150                 155                 160 


Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe Phe Pro 
                165                 170                 175     


Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val His Ser 
            180                 185                 190         


Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Arg Asn Tyr Ser Tyr 
        195                 200                 205             


Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His Asn Pro 
    210                 215                 220                 


Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser Glu Glu 
225                 230                 235                 240 


Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn Ile Ser 
                245                 250                 255     


Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala Ser Tyr 
            260                 265                 270         


His Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu Leu Gly 
        275                 280                 285             


Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Gly Leu Val Leu Met Ala 
    290                 295                 300                 


Met Val Lys Lys Lys Asn Ser 
305                 310     


<210>  17
<211>  1565
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Leu Ser Trp Arg Leu Gln Thr Gly Pro Glu Lys Ala Glu Leu Gln 
1               5                   10                  15      


Glu Leu Asn Ala Arg Leu Tyr Asp Tyr Val Cys Arg Val Arg Glu Leu 
            20                  25                  30          


Glu Arg Glu Asn Leu Leu Leu Glu Glu Glu Leu Arg Gly Arg Arg Gly 
        35                  40                  45              


Arg Glu Gly Leu Trp Ala Glu Gly Gln Ala Arg Cys Ala Glu Glu Ala 
    50                  55                  60                  


Arg Ser Leu Arg Gln Gln Leu Asp Glu Leu Ser Trp Ala Thr Ala Leu 
65                  70                  75                  80  


Ala Glu Gly Glu Arg Asp Ala Leu Arg Arg Glu Leu Arg Glu Leu Gln 
                85                  90                  95      


Arg Leu Asp Ala Glu Glu Arg Ala Ala Arg Gly Arg Leu Asp Ala Glu 
            100                 105                 110         


Leu Gly Ala Gln Gln Arg Glu Leu Gln Glu Ala Leu Gly Ala Arg Ala 
        115                 120                 125             


Ala Leu Glu Ala Leu Leu Gly Arg Leu Gln Ala Glu Arg Arg Gly Leu 
    130                 135                 140                 


Asp Ala Ala His Glu Arg Asp Val Arg Glu Leu Arg Ala Arg Ala Ala 
145                 150                 155                 160 


Ser Leu Thr Met His Phe Arg Ala Arg Ala Thr Gly Pro Ala Ala Pro 
                165                 170                 175     


Pro Pro Arg Leu Arg Glu Val His Asp Ser Tyr Ala Leu Leu Val Ala 
            180                 185                 190         


Glu Ser Trp Arg Glu Thr Val Gln Leu Tyr Glu Asp Glu Val Arg Glu 
        195                 200                 205             


Leu Glu Glu Ala Leu Arg Arg Gly Gln Glu Ser Arg Leu Gln Ala Glu 
    210                 215                 220                 


Glu Glu Thr Arg Leu Cys Ala Gln Glu Ala Glu Ala Leu Arg Arg Glu 
225                 230                 235                 240 


Ala Leu Gly Leu Glu Gln Leu Arg Ala Arg Leu Glu Asp Ala Leu Leu 
                245                 250                 255     


Arg Met Arg Glu Glu Tyr Gly Ile Gln Ala Glu Glu Arg Gln Arg Val 
            260                 265                 270         


Ile Asp Cys Leu Glu Asp Glu Lys Ala Thr Leu Thr Leu Ala Met Ala 
        275                 280                 285             


Asp Trp Leu Arg Asp Tyr Gln Asp Leu Leu Gln Val Lys Thr Gly Leu 
    290                 295                 300                 


Ser Leu Glu Val Ala Thr Tyr Arg Ala Leu Leu Glu Gly Glu Ser Asn 
305                 310                 315                 320 


Pro Glu Ile Val Ile Trp Ala Glu His Val Glu Asn Met Pro Ser Glu 
                325                 330                 335     


Phe Arg Asn Lys Ser Tyr His Tyr Thr Asp Ser Leu Leu Gln Arg Glu 
            340                 345                 350         


Asn Glu Arg Asn Leu Phe Ser Arg Gln Lys Ala Pro Leu Ala Ser Phe 
        355                 360                 365             


Asn His Ser Ser Ala Leu Tyr Ser Asn Leu Ser Gly His Arg Gly Ser 
    370                 375                 380                 


Gln Thr Gly Thr Ser Ile Gly Gly Asp Ala Arg Arg Gly Phe Leu Gly 
385                 390                 395                 400 


Ser Gly Tyr Ser Ser Ser Ala Thr Thr Gln Gln Glu Asn Ser Tyr Gly 
                405                 410                 415     


Lys Ala Val Ser Ser Gln Thr Asn Val Arg Thr Phe Ser Pro Thr Tyr 
            420                 425                 430         


Gly Leu Leu Arg Asn Thr Glu Ala Gln Val Lys Thr Phe Pro Asp Arg 
        435                 440                 445             


Pro Lys Ala Gly Asp Thr Arg Glu Val Pro Val Tyr Ile Gly Glu Asp 
    450                 455                 460                 


Ser Thr Ile Ala Arg Glu Ser Tyr Arg Asp Arg Arg Asp Lys Val Ala 
465                 470                 475                 480 


Ala Gly Ala Ser Glu Ser Thr Arg Ser Asn Glu Arg Thr Val Ile Leu 
                485                 490                 495     


Gly Lys Lys Thr Glu Val Lys Ala Thr Arg Glu Gln Glu Arg Asn Arg 
            500                 505                 510         


Pro Glu Thr Ile Arg Thr Lys Pro Glu Glu Lys Met Phe Asp Ser Lys 
        515                 520                 525             


Glu Lys Ala Ser Glu Glu Arg Asn Leu Arg Trp Glu Glu Leu Thr Lys 
    530                 535                 540                 


Leu Asp Lys Glu Ala Arg Gln Arg Glu Ser Gln Gln Met Lys Glu Lys 
545                 550                 555                 560 


Ala Lys Glu Lys Asp Ser Pro Lys Glu Lys Ser Val Arg Glu Arg Glu 
                565                 570                 575     


Val Pro Ile Ser Leu Glu Val Ser Gln Asp Arg Arg Ala Glu Val Ser 
            580                 585                 590         


Pro Lys Gly Leu Gln Thr Pro Val Lys Asp Ala Gly Gly Gly Thr Gly 
        595                 600                 605             


Arg Glu Ala Glu Ala Arg Glu Leu Arg Phe Arg Leu Gly Thr Ser Asp 
    610                 615                 620                 


Ala Thr Gly Ser Leu Gln Gly Asp Ser Met Thr Glu Thr Val Ala Glu 
625                 630                 635                 640 


Asn Ile Val Thr Ser Ile Leu Lys Gln Phe Thr Gln Ser Pro Glu Thr 
                645                 650                 655     


Glu Ala Ser Ala Asp Ser Phe Pro Asp Thr Lys Val Thr Tyr Val Asp 
            660                 665                 670         


Arg Lys Glu Leu Pro Gly Glu Arg Lys Thr Lys Thr Glu Ile Val Val 
        675                 680                 685             


Glu Ser Lys Leu Thr Glu Asp Val Asp Val Ser Asp Glu Ala Gly Leu 
    690                 695                 700                 


Asp Tyr Leu Leu Ser Lys Asp Ile Lys Glu Val Gly Leu Lys Gly Lys 
705                 710                 715                 720 


Ser Ala Glu Gln Met Ile Gly Asp Ile Ile Asn Leu Gly Leu Lys Gly 
                725                 730                 735     


Arg Glu Gly Arg Ala Lys Val Val Asn Val Glu Ile Val Glu Glu Pro 
            740                 745                 750         


Val Ser Tyr Val Ser Gly Glu Lys Pro Glu Glu Phe Ser Val Pro Phe 
        755                 760                 765             


Lys Val Glu Glu Val Glu Asp Val Ser Pro Gly Pro Trp Gly Leu Val 
    770                 775                 780                 


Lys Glu Glu Glu Gly Tyr Gly Glu Ser Asp Val Thr Phe Ser Val Asn 
785                 790                 795                 800 


Gln His Arg Arg Thr Lys Gln Pro Gln Glu Asn Thr Thr His Val Glu 
                805                 810                 815     


Glu Val Thr Glu Ala Gly Asp Ser Glu Gly Glu Gln Ser Tyr Phe Val 
            820                 825                 830         


Ser Thr Pro Asp Glu His Pro Gly Gly His Asp Arg Asp Asp Gly Ser 
        835                 840                 845             


Val Tyr Gly Gln Ile His Ile Glu Glu Glu Ser Thr Ile Arg Tyr Ser 
    850                 855                 860                 


Trp Gln Asp Glu Ile Val Gln Gly Thr Arg Arg Arg Thr Gln Lys Asp 
865                 870                 875                 880 


Gly Ala Val Gly Glu Lys Val Val Lys Pro Leu Asp Val Pro Ala Pro 
                885                 890                 895     


Ser Leu Glu Gly Asp Leu Gly Ser Thr His Trp Lys Glu Gln Ala Arg 
            900                 905                 910         


Ser Gly Glu Phe His Ala Glu Pro Thr Val Ile Glu Lys Glu Ile Lys 
        915                 920                 925             


Ile Pro His Glu Phe His Thr Ser Met Lys Gly Ile Ser Ser Lys Glu 
    930                 935                 940                 


Pro Arg Gln Gln Leu Val Glu Val Ile Gly Gln Leu Glu Glu Thr Leu 
945                 950                 955                 960 


Pro Glu Arg Met Arg Glu Glu Leu Ser Ala Leu Thr Arg Glu Gly Gln 
                965                 970                 975     


Gly Gly Pro Gly Ser Val Ser Val Asp Val Lys Lys Val Gln Gly Ala 
            980                 985                 990         


Gly Gly Ser Ser Val Thr Leu Val  Ala Glu Val Asn Val  Ser Gln Thr 
        995                 1000                 1005             


Val Asp  Ala Asp Arg Leu Asp  Leu Glu Glu Leu Ser  Lys Asp Glu 
    1010                 1015                 1020             


Ala Ser  Glu Met Glu Lys Ala  Val Glu Ser Val Val  Arg Glu Ser 
    1025                 1030                 1035             


Leu Ser  Arg Gln Arg Ser Pro  Ala Pro Gly Ser Pro  Asp Glu Glu 
    1040                 1045                 1050             


Gly Gly  Ala Glu Ala Pro Ala  Ala Gly Ile Arg Phe  Arg Arg Trp 
    1055                 1060                 1065             


Ala Thr  Arg Glu Leu Tyr Ile  Pro Ser Gly Glu Ser  Glu Val Ala 
    1070                 1075                 1080             


Gly Gly  Ala Ser His Ser Ser  Gly Gln Arg Thr Pro  Gln Gly Pro 
    1085                 1090                 1095             


Val Ser  Ala Thr Val Glu Val  Ser Ser Pro Thr Gly  Phe Ala Gln 
    1100                 1105                 1110             


Ser Gln  Val Leu Glu Asp Val  Ser Gln Ala Ala Arg  His Ile Lys 
    1115                 1120                 1125             


Leu Gly  Pro Ser Glu Val Trp  Arg Thr Glu Arg Met  Ser Tyr Glu 
    1130                 1135                 1140             


Gly Pro  Thr Ala Glu Val Val  Glu Val Ser Ala Gly  Gly Asp Leu 
    1145                 1150                 1155             


Ser Gln  Ala Ala Ser Pro Thr  Gly Ala Ser Arg Ser  Val Arg His 
    1160                 1165                 1170             


Val Thr  Leu Gly Pro Gly Gln  Ser Pro Leu Ser Arg  Glu Val Ile 
    1175                 1180                 1185             


Phe Leu  Gly Pro Ala Pro Ala  Cys Pro Glu Ala Trp  Gly Ser Pro 
    1190                 1195                 1200             


Glu Pro  Gly Pro Ala Glu Ser  Ser Ala Asp Met Asp  Gly Ser Gly 
    1205                 1210                 1215             


Arg His  Ser Thr Phe Gly Cys  Arg Gln Phe His Ala  Glu Lys Glu 
    1220                 1225                 1230             


Ile Ile  Phe Gln Gly Pro Ile  Ser Ala Ala Gly Lys  Val Gly Asp 
    1235                 1240                 1245             


Tyr Phe  Ala Thr Glu Glu Ser  Val Gly Thr Gln Thr  Ser Val Arg 
    1250                 1255                 1260             


Gln Leu  Gln Leu Gly Pro Lys  Glu Gly Phe Ser Gly  Gln Ile Gln 
    1265                 1270                 1275             


Phe Thr  Ala Pro Leu Ser Asp  Lys Val Glu Leu Gly  Val Ile Gly 
    1280                 1285                 1290             


Asp Ser  Val His Met Glu Gly  Leu Pro Gly Ser Ser  Thr Ser Ile 
    1295                 1300                 1305             


Arg His  Ile Ser Ile Gly Pro  Gln Arg His Gln Thr  Thr Gln Gln 
    1310                 1315                 1320             


Ile Val  Tyr His Gly Leu Val  Pro Gln Leu Gly Glu  Ser Gly Asp 
    1325                 1330                 1335             


Ser Glu  Ser Thr Val His Gly  Glu Gly Ser Ala Asp  Val His Gln 
    1340                 1345                 1350             


Ala Thr  His Ser His Thr Ser  Gly Arg Gln Thr Val  Met Thr Glu 
    1355                 1360                 1365             


Lys Ser  Thr Phe Gln Ser Val  Val Ser Glu Ser Pro  Gln Glu Asp 
    1370                 1375                 1380             


Ser Ala  Glu Asp Thr Ser Gly  Ala Glu Met Thr Ser  Gly Val Ser 
    1385                 1390                 1395             


Arg Ser  Phe Arg His Ile Arg  Leu Gly Pro Thr Glu  Thr Glu Thr 
    1400                 1405                 1410             


Ser Glu  His Ile Ala Ile Arg  Gly Pro Val Ser Arg  Thr Phe Val 
    1415                 1420                 1425             


Leu Ala  Gly Ser Ala Asp Ser  Pro Glu Leu Gly Lys  Leu Ala Asp 
    1430                 1435                 1440             


Ser Ser  Arg Thr Leu Arg His  Ile Ala Pro Gly Pro  Lys Glu Thr 
    1445                 1450                 1455             


Ser Phe  Thr Phe Gln Met Asp  Val Ser Asn Val Glu  Ala Ile Arg 
    1460                 1465                 1470             


Ser Arg  Thr Gln Glu Ala Gly  Ala Leu Gly Val Ser  Asp Arg Gly 
    1475                 1480                 1485             


Ser Trp  Arg Asp Ala Asp Ser  Arg Asn Asp Gln Ala  Val Gly Val 
    1490                 1495                 1500             


Ser Phe  Lys Ala Ser Ala Gly  Glu Gly Asp Gln Ala  His Arg Glu 
    1505                 1510                 1515             


Gln Gly  Lys Glu Gln Ala Met  Phe Asp Lys Lys Val  Gln Leu Gln 
    1520                 1525                 1530             


Arg Met  Val Asp Gln Arg Ser  Val Ile Ser Asp Glu  Lys Lys Val 
    1535                 1540                 1545             


Ala Leu  Leu Tyr Leu Asp Asn  Glu Glu Glu Glu Asn  Asp Gly His 
    1550                 1555                 1560             


Trp Phe  
    1565 


<210>  18
<211>  1253
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Leu Ser Trp Arg Leu Gln Thr Gly Pro Glu Lys Ala Glu Leu Gln 
1               5                   10                  15      


Glu Leu Asn Ala Arg Leu Tyr Asp Tyr Val Cys Arg Val Arg Glu Leu 
            20                  25                  30          


Glu Arg Glu Asn Leu Leu Leu Glu Glu Glu Leu Arg Gly Arg Arg Gly 
        35                  40                  45              


Arg Glu Gly Leu Trp Ala Glu Gly Gln Ala Arg Cys Ala Glu Glu Ala 
    50                  55                  60                  


Arg Ser Leu Arg Gln Gln Leu Asp Glu Leu Ser Trp Ala Thr Ala Leu 
65                  70                  75                  80  


Ala Glu Gly Glu Arg Asp Ala Leu Arg Arg Glu Leu Arg Glu Leu Gln 
                85                  90                  95      


Arg Leu Asp Ala Glu Glu Arg Ala Ala Arg Gly Arg Leu Asp Ala Glu 
            100                 105                 110         


Leu Gly Ala Gln Gln Arg Glu Leu Gln Glu Ala Leu Gly Ala Arg Ala 
        115                 120                 125             


Ala Leu Glu Ala Leu Leu Gly Arg Leu Gln Ala Glu Arg Arg Gly Leu 
    130                 135                 140                 


Asp Ala Ala His Glu Arg Asp Val Arg Glu Leu Arg Ala Arg Ala Ala 
145                 150                 155                 160 


Ser Leu Thr Met His Phe Arg Ala Arg Ala Thr Gly Pro Ala Ala Pro 
                165                 170                 175     


Pro Pro Arg Leu Arg Glu Val His Asp Ser Tyr Ala Leu Leu Val Ala 
            180                 185                 190         


Glu Ser Trp Arg Glu Thr Val Gln Leu Tyr Glu Asp Glu Val Arg Glu 
        195                 200                 205             


Leu Glu Glu Ala Leu Arg Arg Gly Gln Glu Ser Arg Leu Gln Ala Glu 
    210                 215                 220                 


Glu Glu Thr Arg Leu Cys Ala Gln Glu Ala Glu Ala Leu Arg Arg Glu 
225                 230                 235                 240 


Ala Leu Gly Leu Glu Gln Leu Arg Ala Arg Leu Glu Asp Ala Leu Leu 
                245                 250                 255     


Arg Met Arg Glu Glu Tyr Gly Ile Gln Ala Glu Glu Arg Gln Arg Val 
            260                 265                 270         


Ile Asp Cys Leu Glu Asp Glu Lys Ala Thr Leu Thr Leu Ala Met Ala 
        275                 280                 285             


Asp Trp Leu Arg Asp Tyr Gln Asp Leu Leu Gln Val Lys Thr Gly Leu 
    290                 295                 300                 


Ser Leu Glu Val Ala Thr Tyr Arg Ala Leu Leu Glu Gly Glu Ser Asn 
305                 310                 315                 320 


Pro Glu Ile Val Ile Trp Ala Glu His Val Glu Asn Met Pro Ser Glu 
                325                 330                 335     


Phe Arg Asn Lys Ser Tyr His Tyr Thr Asp Ser Leu Leu Gln Arg Glu 
            340                 345                 350         


Asn Glu Arg Asn Leu Phe Ser Arg Gln Lys Ala Pro Leu Ala Ser Phe 
        355                 360                 365             


Asn His Ser Ser Ala Leu Tyr Ser Asn Leu Ser Gly His Arg Gly Ser 
    370                 375                 380                 


Gln Thr Gly Thr Ser Ile Gly Gly Asp Ala Arg Arg Gly Phe Leu Gly 
385                 390                 395                 400 


Ser Gly Tyr Ser Ser Ser Ala Thr Thr Gln Gln Glu Asn Ser Tyr Gly 
                405                 410                 415     


Lys Ala Val Ser Ser Gln Thr Asn Val Arg Thr Phe Ser Pro Thr Tyr 
            420                 425                 430         


Gly Leu Leu Arg Asn Thr Glu Ala Gln Val Lys Thr Phe Pro Asp Arg 
        435                 440                 445             


Pro Lys Ala Gly Asp Thr Arg Glu Val Pro Val Tyr Ile Gly Glu Asp 
    450                 455                 460                 


Ser Thr Ile Ala Arg Glu Ser Tyr Arg Asp Arg Arg Asp Lys Val Ala 
465                 470                 475                 480 


Ala Gly Ala Ser Glu Ser Thr Arg Ser Asn Glu Arg Thr Val Ile Leu 
                485                 490                 495     


Gly Lys Lys Thr Glu Val Lys Ala Thr Arg Glu Gln Glu Arg Asn Arg 
            500                 505                 510         


Pro Glu Thr Ile Arg Thr Lys Pro Glu Glu Lys Met Phe Asp Ser Lys 
        515                 520                 525             


Glu Lys Ala Ser Glu Glu Arg Asn Leu Arg Trp Glu Glu Leu Thr Lys 
    530                 535                 540                 


Leu Asp Lys Glu Ala Arg Gln Arg Glu Ser Gln Gln Met Lys Glu Lys 
545                 550                 555                 560 


Ala Lys Glu Lys Asp Ser Pro Lys Glu Lys Ser Val Arg Glu Arg Glu 
                565                 570                 575     


Val Pro Ile Ser Leu Glu Val Ser Gln Asp Arg Arg Ala Glu Val Ser 
            580                 585                 590         


Pro Lys Gly Leu Gln Thr Pro Val Lys Asp Ala Gly Gly Gly Thr Gly 
        595                 600                 605             


Arg Glu Ala Glu Ala Arg Glu Leu Arg Phe Arg Leu Gly Thr Ser Asp 
    610                 615                 620                 


Ala Thr Gly Ser Leu Gln Gly Asp Ser Met Thr Glu Thr Val Ala Glu 
625                 630                 635                 640 


Asn Ile Val Thr Ser Ile Leu Lys Gln Phe Thr Gln Ser Pro Glu Thr 
                645                 650                 655     


Glu Ala Ser Ala Asp Ser Phe Pro Asp Thr Lys Val Thr Tyr Val Asp 
            660                 665                 670         


Arg Lys Glu Leu Pro Gly Glu Arg Lys Thr Lys Thr Glu Ile Val Val 
        675                 680                 685             


Glu Ser Lys Leu Thr Glu Asp Val Asp Val Ser Asp Glu Ala Gly Leu 
    690                 695                 700                 


Asp Tyr Leu Leu Ser Lys Asp Ile Lys Glu Val Gly Leu Lys Gly Lys 
705                 710                 715                 720 


Ser Ala Glu Gln Met Ile Gly Asp Ile Ile Asn Leu Gly Leu Lys Gly 
                725                 730                 735     


Arg Glu Gly Arg Ala Lys Val Val Asn Val Glu Ile Val Glu Glu Pro 
            740                 745                 750         


Val Ser Tyr Val Ser Gly Glu Lys Pro Glu Glu Phe Ser Val Pro Phe 
        755                 760                 765             


Lys Val Glu Glu Val Glu Asp Val Ser Pro Gly Pro Trp Gly Leu Val 
    770                 775                 780                 


Lys Glu Glu Glu Gly Tyr Gly Glu Ser Asp Val Thr Phe Ser Val Asn 
785                 790                 795                 800 


Gln His Arg Arg Thr Lys Gln Pro Gln Glu Asn Thr Thr His Val Glu 
                805                 810                 815     


Glu Val Thr Glu Ala Gly Asp Ser Glu Gly Glu Gln Ser Tyr Phe Val 
            820                 825                 830         


Ser Thr Pro Asp Glu His Pro Gly Gly His Asp Arg Asp Asp Gly Ser 
        835                 840                 845             


Val Tyr Gly Gln Ile His Ile Glu Glu Glu Ser Thr Ile Arg Tyr Ser 
    850                 855                 860                 


Trp Gln Asp Glu Ile Val Gln Gly Thr Arg Arg Arg Thr Gln Lys Asp 
865                 870                 875                 880 


Gly Ala Val Gly Glu Lys Val Val Lys Pro Leu Asp Val Pro Ala Pro 
                885                 890                 895     


Ser Leu Glu Gly Asp Leu Gly Ser Thr His Trp Lys Glu Gln Ala Arg 
            900                 905                 910         


Ser Gly Glu Phe His Ala Glu Pro Thr Val Ile Glu Lys Glu Ile Lys 
        915                 920                 925             


Ile Pro His Glu Phe His Thr Ser Met Lys Gly Ile Ser Ser Lys Glu 
    930                 935                 940                 


Pro Arg Gln Gln Leu Val Glu Val Ile Gly Gln Leu Glu Glu Thr Leu 
945                 950                 955                 960 


Pro Glu Arg Met Arg Glu Glu Leu Ser Ala Leu Thr Arg Glu Gly Gln 
                965                 970                 975     


Gly Gly Pro Gly Ser Val Ser Val Asp Val Lys Lys Val Gln Gly Ala 
            980                 985                 990         


Gly Gly Ser Ser Val Thr Leu Val  Ala Glu Val Asn Val  Ser Gln Thr 
        995                 1000                 1005             


Val Asp  Ala Asp Arg Leu Asp  Leu Glu Glu Leu Ser  Lys Asp Glu 
    1010                 1015                 1020             


Ala Ser  Glu Met Glu Lys Ala  Val Glu Ser Val Val  Arg Glu Ser 
    1025                 1030                 1035             


Leu Ser  Arg Gln Arg Ser Pro  Ala Pro Gly Ser Pro  Asp Glu Glu 
    1040                 1045                 1050             


Gly Gly  Ala Glu Ala Pro Ala  Ala Gly Ile Arg Phe  Arg Arg Trp 
    1055                 1060                 1065             


Ala Thr  Arg Glu Leu Tyr Ile  Pro Ser Gly Glu Ser  Glu Val Ala 
    1070                 1075                 1080             


Gly Gly  Ala Ser His Ser Ser  Gly Gln Arg Thr Pro  Gln Gly Pro 
    1085                 1090                 1095             


Val Ser  Ala Thr Val Glu Val  Ser Ser Pro Thr Gly  Phe Ala Gln 
    1100                 1105                 1110             


Ser Gln  Val Leu Glu Asp Val  Ser Gln Ala Ala Arg  His Ile Lys 
    1115                 1120                 1125             


Leu Gly  Pro Ser Glu Val Trp  Arg Thr Glu Arg Met  Ser Tyr Glu 
    1130                 1135                 1140             


Gly Pro  Thr Ala Glu Val Val  Glu Met Asp Val Ser  Asn Val Glu 
    1145                 1150                 1155             


Ala Ile  Arg Ser Arg Thr Gln  Glu Ala Gly Ala Leu  Gly Val Ser 
    1160                 1165                 1170             


Asp Arg  Gly Ser Trp Arg Asp  Ala Asp Ser Arg Asn  Asp Gln Ala 
    1175                 1180                 1185             


Val Gly  Val Ser Phe Lys Ala  Ser Ala Gly Glu Gly  Asp Gln Ala 
    1190                 1195                 1200             


His Arg  Glu Gln Gly Lys Glu  Gln Ala Met Phe Asp  Lys Lys Val 
    1205                 1210                 1215             


Gln Leu  Gln Arg Met Val Asp  Gln Arg Ser Val Ile  Ser Asp Glu 
    1220                 1225                 1230             


Lys Lys  Val Ala Leu Leu Tyr  Leu Asp Asn Glu Glu  Glu Glu Asn 
    1235                 1240                 1245             


Asp Gly  His Trp Phe 
    1250             


<210>  19
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  19

Arg Thr Phe Ser Pro Thr Tyr Gly Leu 
1               5                   


<210>  20
<211>  807
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(807)

<400>  20
atg ctc ctg gcg ctc ctc cca gtg ctg ggg ata cac ttt gtc ctg aga         48
Met Leu Leu Ala Leu Leu Pro Val Leu Gly Ile His Phe Val Leu Arg           
1               5                   10                  15                

gat gcc caa gct cag tca gtg acg cag ccc gat gct cgc gcc act gtc         96
Asp Ala Gln Ala Gln Ser Val Thr Gln Pro Asp Ala Arg Ala Thr Val           
            20                  25                  30                    

tct gaa gga gcc tct ctg cgg ctg aga tgc aag tat tcc tac tct ggg        144
Ser Glu Gly Ala Ser Leu Arg Leu Arg Cys Lys Tyr Ser Tyr Ser Gly           
        35                  40                  45                        

aca cct tat ctg ttc tgg tat gtc cag tac ccg cgg cag ggg ctg cag        192
Thr Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Arg Gln Gly Leu Gln           
    50                  55                  60                            

ctg ctc ctc aag tac tat tca gga gac cca gtg gtt caa gga gtg aat        240
Leu Leu Leu Lys Tyr Tyr Ser Gly Asp Pro Val Val Gln Gly Val Asn           
65                  70                  75                  80            

ggc ttc gag gct gag ttc agc aag agt aac tct tcc ttc cac ctg cgg        288
Gly Phe Glu Ala Glu Phe Ser Lys Ser Asn Ser Ser Phe His Leu Arg           
                85                  90                  95                

aaa gcc tct gtg cac tgg agc gac tct gct gtg tac ttc tgt gtt ttg        336
Lys Ala Ser Val His Trp Ser Asp Ser Ala Val Tyr Phe Cys Val Leu           
            100                 105                 110                   

agc tat agc aat aac aga atc ttc ttt ggt gat ggg acg cag ctg gtg        384
Ser Tyr Ser Asn Asn Arg Ile Phe Phe Gly Asp Gly Thr Gln Leu Val           
        115                 120                 125                       

atg aag ccc aac atc cag aac cca gaa cct gct gtg tac cag tta aaa        432
Met Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys           
    130                 135                 140                           

gat cct cgg tct cag gac agc acc ctc tgc ctg ttc acc gac ttt gac        480
Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp           
145                 150                 155                 160           

tcc caa atc aat gtg ccg aaa acc atg gaa tct gga acg ttc atc act        528
Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr           
                165                 170                 175               

gac aaa act gtg ctg gac atg aaa gct atg gat tcc aag agc aat ggg        576
Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly           
            180                 185                 190                   

gcc att gcc tgg agc aac cag aca agc ttc acc tgc caa gat atc ttc        624
Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe           
        195                 200                 205                       

aaa gag acc aac gcc acc tac ccc agt tca gac gtt ccc tgt gat gcc        672
Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala           
    210                 215                 220                           

acg ttg act gag aaa agc ttt gaa aca gat atg aac cta aac ttt caa        720
Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln           
225                 230                 235                 240           

aac ctg tca gtt atg gga ctc cga atc ctc ctg ctg aaa gta gcc gga        768
Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly           
                245                 250                 255               

ttt aac ctg ctc atg acg ctg agg ctg tgg tcc agt taa                    807
Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser                           
            260                 265                                       


<210>  21
<211>  268
<212>  PRT
<213>  Mus musculus

<400>  21

Met Leu Leu Ala Leu Leu Pro Val Leu Gly Ile His Phe Val Leu Arg 
1               5                   10                  15      


Asp Ala Gln Ala Gln Ser Val Thr Gln Pro Asp Ala Arg Ala Thr Val 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Arg Leu Arg Cys Lys Tyr Ser Tyr Ser Gly 
        35                  40                  45              


Thr Pro Tyr Leu Phe Trp Tyr Val Gln Tyr Pro Arg Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Tyr Ser Gly Asp Pro Val Val Gln Gly Val Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Ser Lys Ser Asn Ser Ser Phe His Leu Arg 
                85                  90                  95      


Lys Ala Ser Val His Trp Ser Asp Ser Ala Val Tyr Phe Cys Val Leu 
            100                 105                 110         


Ser Tyr Ser Asn Asn Arg Ile Phe Phe Gly Asp Gly Thr Gln Leu Val 
        115                 120                 125             


Met Lys Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys 
    130                 135                 140                 


Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp 
145                 150                 155                 160 


Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr 
                165                 170                 175     


Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly 
            180                 185                 190         


Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe 
        195                 200                 205             


Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala 
    210                 215                 220                 


Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln 
225                 230                 235                 240 


Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly 
                245                 250                 255     


Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265             


<210>  22
<211>  942
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(942)

<220>
<221>  misc_feature
<222>  (582)..(583)
<223>  n is a, c, g, or t

<400>  22
atg tct aac act gtc ctc gct gat tct gcc tgg ggc atc acc ctg cta         48
Met Ser Asn Thr Val Leu Ala Asp Ser Ala Trp Gly Ile Thr Leu Leu           
1               5                   10                  15                

tct tgg gtt act gtc ttt ctc ttg gga aca agt tca gca gat tct ggg         96
Ser Trp Val Thr Val Phe Leu Leu Gly Thr Ser Ser Ala Asp Ser Gly           
            20                  25                  30                    

gtt gtc cag tct cca aga cac ata atc aaa gaa aag gga gga agg tcc        144
Val Val Gln Ser Pro Arg His Ile Ile Lys Glu Lys Gly Gly Arg Ser           
        35                  40                  45                        

gtt ctg acg tgt att ccc atc tct gga cat agc aat gtg gtc tgg tac        192
Val Leu Thr Cys Ile Pro Ile Ser Gly His Ser Asn Val Val Trp Tyr           
    50                  55                  60                            

cag cag act ctg ggg aag gaa tta aag ttc ctt att cag cat tat gaa        240
Gln Gln Thr Leu Gly Lys Glu Leu Lys Phe Leu Ile Gln His Tyr Glu           
65                  70                  75                  80            

aag gtg gag aga gac aaa gga ttc cta ccc agc aga ttc tca gtc caa        288
Lys Val Glu Arg Asp Lys Gly Phe Leu Pro Ser Arg Phe Ser Val Gln           
                85                  90                  95                

cag ttt gat gac tat cac tct gaa atg aac atg agt gcc ttg gaa ctg        336
Gln Phe Asp Asp Tyr His Ser Glu Met Asn Met Ser Ala Leu Glu Leu           
            100                 105                 110                   

gag gac tct gct atg tac ttc tgt gcc agc tct ctg ggg ggt gga gaa        384
Glu Asp Ser Ala Met Tyr Phe Cys Ala Ser Ser Leu Gly Gly Gly Glu           
        115                 120                 125                       

gtc ttc ttt ggt aaa gga acc aga ctc aca gtt gta gag gat ctg aga        432
Val Phe Phe Gly Lys Gly Thr Arg Leu Thr Val Val Glu Asp Leu Arg           
    130                 135                 140                           

aat gtg act cca ccc aag gtc tcc ttg ttt gag cca tca aaa gca gag        480
Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu           
145                 150                 155                 160           

att gca aac aaa caa aag gct acc ctc gtg tgc ttg gcc agg ggc ttc        528
Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe           
                165                 170                 175               

ttc cct gac cac gtg gag ctg agc tgg tgg gtg aat ggc aag gag gtc        576
Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val           
            180                 185                 190                   

cac agn ngg gtc agc acg gac cct cag gcc tac aag gag agc aat tat        624
His Xaa Xaa Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr           
        195                 200                 205                       

agc tac tgc ctg agc agc cgc ctg agg gtc tct gct acc ttc tgg cac        672
Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His           
    210                 215                 220                           

aat cct cgc aac cac ttc cgc tgc caa gtg cag ttc cat ggg ctt tca        720
Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser           
225                 230                 235                 240           

gag gag gac aag tgg cca gag ggc tca ccc aaa cct gtc aca cag aac        768
Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn           
                245                 250                 255               

atc agt gca gag gcc tgg ggc cga gca gac tgt ggg att acc tca gca        816
Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala           
            260                 265                 270                   

tcc tat caa caa ggg gtc ttg tct gcc acc atc ctc tat gag atc ctg        864
Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu           
        275                 280                 285                       

cta ggg aaa gcc acc ctg tat gct gtg ctt gtc agt aca ctg gtg gtg        912
Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val           
    290                 295                 300                           

atg gct atg gtc aaa aaa aag aat tcc taa                                942
Met Ala Met Val Lys Lys Lys Asn Ser                                       
305                 310                                                   


<210>  23
<211>  313
<212>  PRT
<213>  Mus musculus

<220>
<221>  misc_feature
<222>  (194)..(194)
<223>  The 'Xaa' at location 194 stands for Arg, or Ser.

<220>
<221>  misc_feature
<222>  (195)..(195)
<223>  The 'Xaa' at location 195 stands for Arg, Gly, or Trp.

<400>  23

Met Ser Asn Thr Val Leu Ala Asp Ser Ala Trp Gly Ile Thr Leu Leu 
1               5                   10                  15      


Ser Trp Val Thr Val Phe Leu Leu Gly Thr Ser Ser Ala Asp Ser Gly 
            20                  25                  30          


Val Val Gln Ser Pro Arg His Ile Ile Lys Glu Lys Gly Gly Arg Ser 
        35                  40                  45              


Val Leu Thr Cys Ile Pro Ile Ser Gly His Ser Asn Val Val Trp Tyr 
    50                  55                  60                  


Gln Gln Thr Leu Gly Lys Glu Leu Lys Phe Leu Ile Gln His Tyr Glu 
65                  70                  75                  80  


Lys Val Glu Arg Asp Lys Gly Phe Leu Pro Ser Arg Phe Ser Val Gln 
                85                  90                  95      


Gln Phe Asp Asp Tyr His Ser Glu Met Asn Met Ser Ala Leu Glu Leu 
            100                 105                 110         


Glu Asp Ser Ala Met Tyr Phe Cys Ala Ser Ser Leu Gly Gly Gly Glu 
        115                 120                 125             


Val Phe Phe Gly Lys Gly Thr Arg Leu Thr Val Val Glu Asp Leu Arg 
    130                 135                 140                 


Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro Ser Lys Ala Glu 
145                 150                 155                 160 


Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu Ala Arg Gly Phe 
                165                 170                 175     


Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu Val 
            180                 185                 190         


His Xaa Xaa Val Ser Thr Asp Pro Gln Ala Tyr Lys Glu Ser Asn Tyr 
        195                 200                 205             


Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp His 
    210                 215                 220                 


Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe His Gly Leu Ser 
225                 230                 235                 240 


Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro Val Thr Gln Asn 
                245                 250                 255     


Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly Ile Thr Ser Ala 
            260                 265                 270         


Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile Leu Tyr Glu Ile Leu 
        275                 280                 285             


Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser Thr Leu Val Val 
    290                 295                 300                 


Met Ala Met Val Lys Lys Lys Asn Ser 
305                 310             


<210>  24
<211>  810
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(810)

<400>  24
atg ctc ctg gcg ctc ctc cca gtg ctg ggg ata cac ttt gtc ctg aga         48
Met Leu Leu Ala Leu Leu Pro Val Leu Gly Ile His Phe Val Leu Arg           
1               5                   10                  15                

gat gcc caa gct cag tca gtg acg cag ccc gat gct cgc gtc act gtc         96
Asp Ala Gln Ala Gln Ser Val Thr Gln Pro Asp Ala Arg Val Thr Val           
            20                  25                  30                    

tct gaa gga gcc tct ctg cag ctg aga tgc aag tat tcc tac tct ggg        144
Ser Glu Gly Ala Ser Leu Gln Leu Arg Cys Lys Tyr Ser Tyr Ser Gly           
        35                  40                  45                        

aca cct tat ctg ttc tgg tat gcc cag tac ccg cgg cag ggg ctg cag        192
Thr Pro Tyr Leu Phe Trp Tyr Ala Gln Tyr Pro Arg Gln Gly Leu Gln           
    50                  55                  60                            

ctg ctc ctc aag tac tat tca gga gac cca gtg gtt caa gga gtg aat        240
Leu Leu Leu Lys Tyr Tyr Ser Gly Asp Pro Val Val Gln Gly Val Asn           
65                  70                  75                  80            

ggc ttc gag gct gag ttc agc aag agt aac tct tcc ttc cac ctg cgg        288
Gly Phe Glu Ala Glu Phe Ser Lys Ser Asn Ser Ser Phe His Leu Arg           
                85                  90                  95                

aaa gcc tct gtg cac tgg agc gac tct gct gtg tac ttc tgt gtt ttg        336
Lys Ala Ser Val His Trp Ser Asp Ser Ala Val Tyr Phe Cys Val Leu           
            100                 105                 110                   

agg tac gga ggc aat aat aag ctg act ttt ggt caa gga acc gtt ctg        384
Arg Tyr Gly Gly Asn Asn Lys Leu Thr Phe Gly Gln Gly Thr Val Leu           
        115                 120                 125                       

agt gtt ata cca gac atc cag aac cca gaa cct gct gtg tac cag tta        432
Ser Val Ile Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu           
    130                 135                 140                           

aaa gat cct cgg tct cag gac agc acc ctc tgc ctg ttc acc gac ttt        480
Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe           
145                 150                 155                 160           

gac tcc caa atc aat gtg ccg aaa acc atg gaa tct gga acg ttc atc        528
Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile           
                165                 170                 175               

act gac aaa act gtg ctg gac atg aaa gct atg gat tcc aag agc aat        576
Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn           
            180                 185                 190                   

ggg gcc att gcc tgg agc aac cag aca agc ttc acc tgc caa gat atc        624
Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile           
        195                 200                 205                       

ttc aaa gag acc aac gcc acc tac ccc agt tca gac gtt ccc tgt gat        672
Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp           
    210                 215                 220                           

gcc acg ttg act gag aaa agc ttt gaa aca gat atg aac cta aac ttt        720
Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe           
225                 230                 235                 240           

cag aac ctg tca gtt atg gga ctc cga atc ctc ctg ctg aaa gta gcc        768
Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala           
                245                 250                 255               

gga ttt aac ctg ctc atg acg ctg agg ctg tgg tcc agt tga                810
Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser                       
            260                 265                                       


<210>  25
<211>  269
<212>  PRT
<213>  Mus musculus

<400>  25

Met Leu Leu Ala Leu Leu Pro Val Leu Gly Ile His Phe Val Leu Arg 
1               5                   10                  15      


Asp Ala Gln Ala Gln Ser Val Thr Gln Pro Asp Ala Arg Val Thr Val 
            20                  25                  30          


Ser Glu Gly Ala Ser Leu Gln Leu Arg Cys Lys Tyr Ser Tyr Ser Gly 
        35                  40                  45              


Thr Pro Tyr Leu Phe Trp Tyr Ala Gln Tyr Pro Arg Gln Gly Leu Gln 
    50                  55                  60                  


Leu Leu Leu Lys Tyr Tyr Ser Gly Asp Pro Val Val Gln Gly Val Asn 
65                  70                  75                  80  


Gly Phe Glu Ala Glu Phe Ser Lys Ser Asn Ser Ser Phe His Leu Arg 
                85                  90                  95      


Lys Ala Ser Val His Trp Ser Asp Ser Ala Val Tyr Phe Cys Val Leu 
            100                 105                 110         


Arg Tyr Gly Gly Asn Asn Lys Leu Thr Phe Gly Gln Gly Thr Val Leu 
        115                 120                 125             


Ser Val Ile Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu 
    130                 135                 140                 


Lys Asp Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe 
145                 150                 155                 160 


Asp Ser Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile 
                165                 170                 175     


Thr Asp Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn 
            180                 185                 190         


Gly Ala Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile 
        195                 200                 205             


Phe Lys Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp 
    210                 215                 220                 


Ala Thr Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe 
225                 230                 235                 240 


Gln Asn Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala 
                245                 250                 255     


Gly Phe Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265                 


<210>  26
<211>  906
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(906)

<400>  26
atg ggc tcc aga ctc ttc ttt gtg gtt ttg att ctc ctg tgt gca aaa         48
Met Gly Ser Arg Leu Phe Phe Val Val Leu Ile Leu Leu Cys Ala Lys           
1               5                   10                  15                

cac atg gag gct gca gtc acc caa agt cca aga agc aag gtg gcg gta         96
His Met Glu Ala Ala Val Thr Gln Ser Pro Arg Ser Lys Val Ala Val           
            20                  25                  30                    

aca gga gga aag gtg aca ttg agc tgt cac cag act aat aac cat gac        144
Thr Gly Gly Lys Val Thr Leu Ser Cys His Gln Thr Asn Asn His Asp           
        35                  40                  45                        

tat atg tac tgg tat cgg cag gac acg ggg cat ggg ctg agg ctg atc        192
Tyr Met Tyr Trp Tyr Arg Gln Asp Thr Gly His Gly Leu Arg Leu Ile           
    50                  55                  60                            

cat tac tca tat gtc gct gac agc acg gag aaa gga gat atc cct gat        240
His Tyr Ser Tyr Val Ala Asp Ser Thr Glu Lys Gly Asp Ile Pro Asp           
65                  70                  75                  80            

ggg tac aag gcc tcc aga cca agc caa gag aat ttc tct ctc att ctg        288
Gly Tyr Lys Ala Ser Arg Pro Ser Gln Glu Asn Phe Ser Leu Ile Leu           
                85                  90                  95                

gag ttg gct tcc ctt tct cag aca gct gta tat ttc tgt gcc agc agg        336
Glu Leu Ala Ser Leu Ser Gln Thr Ala Val Tyr Phe Cys Ala Ser Arg           
            100                 105                 110                   

tac agg gac acc cag tac ttt ggg cca ggc act cgg ctc ctc gtg tta        384
Tyr Arg Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu Val Leu           
        115                 120                 125                       

gag gat ctg aga aat gtg act cca ccc aag gtc tcc ttg ttt gag cca        432
Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro           
    130                 135                 140                           

tca aaa gca gag att gca aac aag caa aag gct acc ctc gtg tgc ttg        480
Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu           
145                 150                 155                 160           

gcc agg ggc ttc ttc cct gac cac gtg gag ctg agc tgg tgg gtg aat        528
Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn           
                165                 170                 175               

ggc aag gag gtc cac agt ggg gtc agc acg gac cct cag gcc tac aag        576
Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys           
            180                 185                 190                   

gag agc aat tat agc tac tgc ctg agc agc cgc ctg agg gtc tct gct        624
Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala           
        195                 200                 205                       

acc ttc tgg cac aat cct cga aac cac ttc cgc tgc caa gtg cag ttc        672
Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe           
    210                 215                 220                           

cat ggg ctt tca gag gag gac aag tgg cca gag ggc tca ccc aaa cct        720
His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro           
225                 230                 235                 240           

gtc aca cag aac atc agt gca gag gcc tgg ggc cga gca gac tgt gga        768
Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly           
                245                 250                 255               

atc act tca gca tcc tat cat cag ggg gtt ctg tct gca acc atc ctc        816
Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu           
            260                 265                 270                   

tat gag atc cta ctg ggg aag gcc acc cta tat gct gtg ctg gtc agt        864
Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser           
        275                 280                 285                       

ggc ctg gtg ctg atg gcc atg gtc aag aaa aaa aat tcc tag                906
Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser                       
    290                 295                 300                           


<210>  27
<211>  301
<212>  PRT
<213>  Mus musculus

<400>  27

Met Gly Ser Arg Leu Phe Phe Val Val Leu Ile Leu Leu Cys Ala Lys 
1               5                   10                  15      


His Met Glu Ala Ala Val Thr Gln Ser Pro Arg Ser Lys Val Ala Val 
            20                  25                  30          


Thr Gly Gly Lys Val Thr Leu Ser Cys His Gln Thr Asn Asn His Asp 
        35                  40                  45              


Tyr Met Tyr Trp Tyr Arg Gln Asp Thr Gly His Gly Leu Arg Leu Ile 
    50                  55                  60                  


His Tyr Ser Tyr Val Ala Asp Ser Thr Glu Lys Gly Asp Ile Pro Asp 
65                  70                  75                  80  


Gly Tyr Lys Ala Ser Arg Pro Ser Gln Glu Asn Phe Ser Leu Ile Leu 
                85                  90                  95      


Glu Leu Ala Ser Leu Ser Gln Thr Ala Val Tyr Phe Cys Ala Ser Arg 
            100                 105                 110         


Tyr Arg Asp Thr Gln Tyr Phe Gly Pro Gly Thr Arg Leu Leu Val Leu 
        115                 120                 125             


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
    130                 135                 140                 


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
                165                 170                 175     


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
            180                 185                 190         


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
        195                 200                 205             


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
    210                 215                 220                 


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys Pro 
225                 230                 235                 240 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
                245                 250                 255     


Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu 
            260                 265                 270         


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
        275                 280                 285             


Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
    290                 295                 300     


<210>  28
<211>  781
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Thr Gln Ala Asp Leu Met Glu Leu Asp Met Ala Met Glu Pro 
1               5                   10                  15      


Asp Arg Lys Ala Ala Val Ser His Trp Gln Gln Gln Ser Tyr Leu Asp 
            20                  25                  30          


Ser Gly Ile His Ser Gly Ala Thr Thr Thr Ala Pro Ser Leu Ser Gly 
        35                  40                  45              


Lys Gly Asn Pro Glu Glu Glu Asp Val Asp Thr Ser Gln Val Leu Tyr 
    50                  55                  60                  


Glu Trp Glu Gln Gly Phe Ser Gln Ser Phe Thr Gln Glu Gln Val Ala 
65                  70                  75                  80  


Asp Ile Asp Gly Gln Tyr Ala Met Thr Arg Ala Gln Arg Val Arg Ala 
                85                  90                  95      


Ala Met Phe Pro Glu Thr Leu Asp Glu Gly Met Gln Ile Pro Ser Thr 
            100                 105                 110         


Gln Phe Asp Ala Ala His Pro Thr Asn Val Gln Arg Leu Ala Glu Pro 
        115                 120                 125             


Ser Gln Met Leu Lys His Ala Val Val Asn Leu Ile Asn Tyr Gln Asp 
    130                 135                 140                 


Asp Ala Glu Leu Ala Thr Arg Ala Ile Pro Glu Leu Thr Lys Leu Leu 
145                 150                 155                 160 


Asn Asp Glu Asp Gln Val Val Val Asn Lys Ala Ala Val Met Val His 
                165                 170                 175     


Gln Leu Ser Lys Lys Glu Ala Ser Arg His Ala Ile Met Arg Ser Pro 
            180                 185                 190         


Gln Met Val Ser Ala Ile Val Arg Thr Met Gln Asn Thr Asn Asp Val 
        195                 200                 205             


Glu Thr Ala Arg Cys Thr Ala Gly Thr Leu His Asn Leu Ser His His 
    210                 215                 220                 


Arg Glu Gly Leu Leu Ala Ile Phe Lys Ser Gly Gly Ile Pro Ala Leu 
225                 230                 235                 240 


Val Lys Met Leu Gly Ser Pro Val Asp Ser Val Leu Phe Tyr Ala Ile 
                245                 250                 255     


Thr Thr Leu His Asn Leu Leu Leu His Gln Glu Gly Ala Lys Met Ala 
            260                 265                 270         


Val Arg Leu Ala Gly Gly Leu Gln Lys Met Val Ala Leu Leu Asn Lys 
        275                 280                 285             


Thr Asn Val Lys Phe Leu Ala Ile Thr Thr Asp Cys Leu Gln Ile Leu 
    290                 295                 300                 


Ala Tyr Gly Asn Gln Glu Ser Lys Leu Ile Ile Leu Ala Ser Gly Gly 
305                 310                 315                 320 


Pro Gln Ala Leu Val Asn Ile Met Arg Thr Tyr Thr Tyr Glu Lys Leu 
                325                 330                 335     


Leu Trp Thr Thr Ser Arg Val Leu Lys Val Leu Ser Val Cys Ser Ser 
            340                 345                 350         


Asn Lys Pro Ala Ile Val Glu Ala Gly Gly Met Gln Ala Leu Gly Leu 
        355                 360                 365             


His Leu Thr Asp Pro Ser Gln Arg Leu Val Gln Asn Cys Leu Trp Thr 
    370                 375                 380                 


Leu Arg Asn Leu Ser Asp Ala Ala Thr Lys Gln Glu Gly Met Glu Gly 
385                 390                 395                 400 


Leu Leu Gly Thr Leu Val Gln Leu Leu Gly Ser Asp Asp Ile Asn Val 
                405                 410                 415     


Val Thr Cys Ala Ala Gly Ile Leu Ser Asn Leu Thr Cys Asn Asn Tyr 
            420                 425                 430         


Lys Asn Lys Met Met Val Cys Gln Val Gly Gly Ile Glu Ala Leu Val 
        435                 440                 445             


Arg Thr Val Leu Arg Ala Gly Asp Arg Glu Asp Ile Thr Glu Pro Ala 
    450                 455                 460                 


Ile Cys Ala Leu Arg His Leu Thr Ser Arg His Gln Glu Ala Glu Met 
465                 470                 475                 480 


Ala Gln Asn Ala Val Arg Leu His Tyr Gly Leu Pro Val Val Val Lys 
                485                 490                 495     


Leu Leu His Pro Pro Ser His Trp Pro Leu Ile Lys Ala Thr Val Gly 
            500                 505                 510         


Leu Ile Arg Asn Leu Ala Leu Cys Pro Ala Asn His Ala Pro Leu Arg 
        515                 520                 525             


Glu Gln Gly Ala Ile Pro Arg Leu Val Gln Leu Leu Val Arg Ala His 
    530                 535                 540                 


Gln Asp Thr Gln Arg Arg Thr Ser Met Gly Gly Thr Gln Gln Gln Phe 
545                 550                 555                 560 


Val Glu Gly Val Arg Met Glu Glu Ile Val Glu Gly Cys Thr Gly Ala 
                565                 570                 575     


Leu His Ile Leu Ala Arg Asp Val His Asn Arg Ile Val Ile Arg Gly 
            580                 585                 590         


Leu Asn Thr Ile Pro Leu Phe Val Gln Leu Leu Tyr Ser Pro Ile Glu 
        595                 600                 605             


Asn Ile Gln Arg Val Ala Ala Gly Val Leu Cys Glu Leu Ala Gln Asp 
    610                 615                 620                 


Lys Glu Ala Ala Glu Ala Ile Glu Ala Glu Gly Ala Thr Ala Pro Leu 
625                 630                 635                 640 


Thr Glu Leu Leu His Ser Arg Asn Glu Gly Val Ala Thr Tyr Ala Ala 
                645                 650                 655     


Ala Val Leu Phe Arg Met Ser Glu Asp Lys Pro Gln Asp Tyr Lys Lys 
            660                 665                 670         


Arg Leu Ser Val Glu Leu Thr Ser Ser Leu Phe Arg Thr Glu Pro Met 
        675                 680                 685             


Ala Trp Asn Glu Thr Ala Asp Leu Gly Leu Asp Ile Gly Ala Gln Gly 
    690                 695                 700                 


Glu Pro Leu Gly Tyr Arg Gln Asp Asp Pro Ser Tyr Arg Ser Phe His 
705                 710                 715                 720 


Ser Gly Gly Tyr Gly Gln Asp Ala Leu Gly Met Asp Pro Met Met Glu 
                725                 730                 735     


His Glu Met Gly Gly His His Pro Gly Ala Asp Tyr Pro Val Asp Gly 
            740                 745                 750         


Leu Pro Asp Leu Gly His Ala Gln Asp Leu Met Asp Gly Leu Pro Pro 
        755                 760                 765             


Gly Asp Ser Asn Gln Leu Ala Trp Phe Asp Thr Asp Leu 
    770                 775                 780     


<210>  29
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  29

Tyr Leu Asp Ser Gly Ile His Ser Gly Val 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  30

Tyr Leu Asp Ser Gly Ile His Ser Gly Ala 
1               5                   10  


<210>  31
<211>  801
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(801)

<400>  31
atg aag agg ctg ctg tgt tct ctg ctg ggg ctt ctg tgc acc cag gtt         48
Met Lys Arg Leu Leu Cys Ser Leu Leu Gly Leu Leu Cys Thr Gln Val           
1               5                   10                  15                

tgc tgg gtg aaa gga cag caa gtg cag cag agt ccc gca tcc ttg gtt         96
Cys Trp Val Lys Gly Gln Gln Val Gln Gln Ser Pro Ala Ser Leu Val           
            20                  25                  30                    

ctg cag gag ggg gag aac gca gag ctg cag tgt aac ttt tcc tcc aca        144
Leu Gln Glu Gly Glu Asn Ala Glu Leu Gln Cys Asn Phe Ser Ser Thr           
        35                  40                  45                        

gca acc cgg ctg cag tgg ttt tac caa cat cct ggg gga aga ctc gtc        192
Ala Thr Arg Leu Gln Trp Phe Tyr Gln His Pro Gly Gly Arg Leu Val           
    50                  55                  60                            

agc ctg ttc tac aat cct tct ggg aca aag cac act gga aga ctg aca        240
Ser Leu Phe Tyr Asn Pro Ser Gly Thr Lys His Thr Gly Arg Leu Thr           
65                  70                  75                  80            

tcc acc aca gtc act aac gaa cgt cgc agc tct ttg cac att tcc tcc        288
Ser Thr Thr Val Thr Asn Glu Arg Arg Ser Ser Leu His Ile Ser Ser           
                85                  90                  95                

tcc cag aca aca gac tca ggc act tat ttc tgt gct atc ccc cca ggc        336
Ser Gln Thr Thr Asp Ser Gly Thr Tyr Phe Cys Ala Ile Pro Pro Gly           
            100                 105                 110                   

act ggg tct aag ctg tca ttt ggg aag ggg gca aag ctc aca gtg agt        384
Thr Gly Ser Lys Leu Ser Phe Gly Lys Gly Ala Lys Leu Thr Val Ser           
        115                 120                 125                       

cca gac atc cag aac cca gaa cct gct gtg tac cag tta aaa gat cct        432
Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro           
    130                 135                 140                           

cgg tct cag gac agc acc ctc tgc ctg ttc acc gac ttt gac tcc caa        480
Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln           
145                 150                 155                 160           

atc aat gtg ccg aaa acc atg gaa tct gga acg ttc atc act gac aaa        528
Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys           
                165                 170                 175               

act gtg ctg gac atg aaa gct atg gat tcc aag agc aat ggg gcc att        576
Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile           
            180                 185                 190                   

gcc tgg agc aac cag aca agc ttc acc tgc caa gat atc ttc aaa gag        624
Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu           
        195                 200                 205                       

acc aac gcc acc tac ccc agt tca gac gtt ccc tgt gat gcc acg ttg        672
Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu           
    210                 215                 220                           

act gag aaa agc ttt gaa aca gat atg aac cta aac ttt caa aac ctg        720
Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu           
225                 230                 235                 240           

tca gtt atg gga ctc cga atc ctc ctg ctg aaa gta gcc gga ttt aac        768
Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn           
                245                 250                 255               

ctg ctc atg acg ctg agg ctg tgg tcc agt taa                            801
Leu Leu Met Thr Leu Arg Leu Trp Ser Ser                                   
            260                 265                                       


<210>  32
<211>  266
<212>  PRT
<213>  Mus musculus

<400>  32

Met Lys Arg Leu Leu Cys Ser Leu Leu Gly Leu Leu Cys Thr Gln Val 
1               5                   10                  15      


Cys Trp Val Lys Gly Gln Gln Val Gln Gln Ser Pro Ala Ser Leu Val 
            20                  25                  30          


Leu Gln Glu Gly Glu Asn Ala Glu Leu Gln Cys Asn Phe Ser Ser Thr 
        35                  40                  45              


Ala Thr Arg Leu Gln Trp Phe Tyr Gln His Pro Gly Gly Arg Leu Val 
    50                  55                  60                  


Ser Leu Phe Tyr Asn Pro Ser Gly Thr Lys His Thr Gly Arg Leu Thr 
65                  70                  75                  80  


Ser Thr Thr Val Thr Asn Glu Arg Arg Ser Ser Leu His Ile Ser Ser 
                85                  90                  95      


Ser Gln Thr Thr Asp Ser Gly Thr Tyr Phe Cys Ala Ile Pro Pro Gly 
            100                 105                 110         


Thr Gly Ser Lys Leu Ser Phe Gly Lys Gly Ala Lys Leu Thr Val Ser 
        115                 120                 125             


Pro Asp Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp Pro 
    130                 135                 140                 


Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser Gln 
145                 150                 155                 160 


Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp Lys 
                165                 170                 175     


Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala Ile 
            180                 185                 190         


Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys Glu 
        195                 200                 205             


Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr Leu 
    210                 215                 220                 


Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn Leu 
225                 230                 235                 240 


Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn 
                245                 250                 255     


Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265     


<210>  33
<211>  906
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(906)

<400>  33
atg agc tgc agg ctt ctc ctc tat gtt tcc cta tgt ctt gtg gaa aca         48
Met Ser Cys Arg Leu Leu Leu Tyr Val Ser Leu Cys Leu Val Glu Thr           
1               5                   10                  15                

gca ctc atg aac act aaa att act cag tca cca aga tat cta atc ctg         96
Ala Leu Met Asn Thr Lys Ile Thr Gln Ser Pro Arg Tyr Leu Ile Leu           
            20                  25                  30                    

gga aga gca aat aag tct ttg gaa tgt gag caa cat ctg gga cat aat        144
Gly Arg Ala Asn Lys Ser Leu Glu Cys Glu Gln His Leu Gly His Asn           
        35                  40                  45                        

gct atg tac tgg tat aaa cag agc gct gag aag ccg cca gag ctc atg        192
Ala Met Tyr Trp Tyr Lys Gln Ser Ala Glu Lys Pro Pro Glu Leu Met           
    50                  55                  60                            

ttt ctc tac aat ctt aaa cag ttg att cga aat gag acg gtg ccc agt        240
Phe Leu Tyr Asn Leu Lys Gln Leu Ile Arg Asn Glu Thr Val Pro Ser           
65                  70                  75                  80            

cgt ttt ata cct gaa tgc cca gac agc tcc aag cta ctt tta cat ata        288
Arg Phe Ile Pro Glu Cys Pro Asp Ser Ser Lys Leu Leu Leu His Ile           
                85                  90                  95                

tct gcc gtg gat cca gaa gac tca gct gtc tat ttt tgt gcc agc agc        336
Ser Ala Val Asp Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser           
            100                 105                 110                   

caa gga cag aaa cag tac ttc ggt ccc ggc acc agg ctc acg gtt tta        384
Gln Gly Gln Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu           
        115                 120                 125                       

gag gat ctg aga aat gtg act cca ccc aag gtc tcc ttg ttt gag cca        432
Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro           
    130                 135                 140                           

tca aaa gca gag att gca aac aaa caa aag gct acc ctc gtg tgc ttg        480
Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu           
145                 150                 155                 160           

gcc agg ggc ttc ttc cct gac cac gtg gag ctg agc tgg tgg gtg aat        528
Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn           
                165                 170                 175               

ggc aag gag gtc cac agt ggg gtc agc acg gac cct cag gcc tac aag        576
Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys           
            180                 185                 190                   

gag agc aat tat agc tac tgc ctg agc agc cgc ctg agg gtc tct gct        624
Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala           
        195                 200                 205                       

acc ttc tgg cac aat cct cga aac cac ttc cgc tgc caa gtg cag ttc        672
Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe           
    210                 215                 220                           

cat ggg ctt tca gag gag gac aag tgg cca gag ggc tta ccc aaa cct        720
His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Leu Pro Lys Pro           
225                 230                 235                 240           

gtc aca cag aac atc agt gca gag gcc tgg ggc cga gca gac tgt gga        768
Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly           
                245                 250                 255               

atc act tca gca tcc tat cat cag ggg gtt ctg tct gca acc atc ctc        816
Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu           
            260                 265                 270                   

tat gag atc cta ctg ggg aag gcc acc cta tat gct gtg ctg gtc agt        864
Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser           
        275                 280                 285                       

ggc ctg gtg ctg atg gcc atg gtc aag aaa aaa aat tcc taa                906
Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser                       
    290                 295                 300                           


<210>  34
<211>  301
<212>  PRT
<213>  Mus musculus

<400>  34

Met Ser Cys Arg Leu Leu Leu Tyr Val Ser Leu Cys Leu Val Glu Thr 
1               5                   10                  15      


Ala Leu Met Asn Thr Lys Ile Thr Gln Ser Pro Arg Tyr Leu Ile Leu 
            20                  25                  30          


Gly Arg Ala Asn Lys Ser Leu Glu Cys Glu Gln His Leu Gly His Asn 
        35                  40                  45              


Ala Met Tyr Trp Tyr Lys Gln Ser Ala Glu Lys Pro Pro Glu Leu Met 
    50                  55                  60                  


Phe Leu Tyr Asn Leu Lys Gln Leu Ile Arg Asn Glu Thr Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ile Pro Glu Cys Pro Asp Ser Ser Lys Leu Leu Leu His Ile 
                85                  90                  95      


Ser Ala Val Asp Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser 
            100                 105                 110         


Gln Gly Gln Lys Gln Tyr Phe Gly Pro Gly Thr Arg Leu Thr Val Leu 
        115                 120                 125             


Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu Pro 
    130                 135                 140                 


Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys Leu 
145                 150                 155                 160 


Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val Asn 
                165                 170                 175     


Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr Lys 
            180                 185                 190         


Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser Ala 
        195                 200                 205             


Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln Phe 
    210                 215                 220                 


His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Leu Pro Lys Pro 
225                 230                 235                 240 


Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys Gly 
                245                 250                 255     


Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile Leu 
            260                 265                 270         


Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val Ser 
        275                 280                 285             


Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
    290                 295                 300     


<210>  35
<211>  804
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(804)

<400>  35
atg aac aga ttc ctg gga ata tct ttg gtg act cta tgg ttt caa gtg         48
Met Asn Arg Phe Leu Gly Ile Ser Leu Val Thr Leu Trp Phe Gln Val           
1               5                   10                  15                

gcc tgg gca aag agc caa tgg gga gaa gag aat ctt cag gct ctg agc         96
Ala Trp Ala Lys Ser Gln Trp Gly Glu Glu Asn Leu Gln Ala Leu Ser           
            20                  25                  30                    

atc cag gag ggt gaa gat gtc acc atg aac tgc agt tac aag act tac        144
Ile Gln Glu Gly Glu Asp Val Thr Met Asn Cys Ser Tyr Lys Thr Tyr           
        35                  40                  45                        

aca act gtt gtt cag tgg tac aga cag aag tca ggc aaa ggc cct gcc        192
Thr Thr Val Val Gln Trp Tyr Arg Gln Lys Ser Gly Lys Gly Pro Ala           
    50                  55                  60                            

cag cta atc tta ata cgt tca aat gag cga gag aag cgc agt gga aga        240
Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Ser Gly Arg           
65                  70                  75                  80            

ctc aga gcc acc ctt gac act tcc agc cag agc agc tcc ctg tcc atc        288
Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile           
                85                  90                  95                

act ggt act cta gct aca gac act gct gtg tac ttc tgt gct act ggg        336
Thr Gly Thr Leu Ala Thr Asp Thr Ala Val Tyr Phe Cys Ala Thr Gly           
            100                 105                 110                   

ccc aat acc aac aaa gtc gtc ttt gga aca ggg acc aga tta caa gta        384
Pro Asn Thr Asn Lys Val Val Phe Gly Thr Gly Thr Arg Leu Gln Val           
        115                 120                 125                       

tta cca aac atc cag aac cca gaa cct gct gtg tac cag tta aaa gat        432
Leu Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp           
    130                 135                 140                           

cct cgg tct cag gac agc acc ctc tgc ctg ttc acc gac ttt gac tcc        480
Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser           
145                 150                 155                 160           

caa atc aat gtg ccg aaa acc atg gaa tct gga acg ttc atc act gac        528
Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp           
                165                 170                 175               

aaa act gtg ctg gac atg aaa gct atg gat tcc aag agc aat ggg gcc        576
Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala           
            180                 185                 190                   

att gcc tgg agc aac cag aca agc ttc acc tgc caa gat atc ttc aaa        624
Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys           
        195                 200                 205                       

gag acc aac gcc acc tac ccc agt tca gac gtt ccc tgt gat gcc acg        672
Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr           
    210                 215                 220                           

ttg act gag aaa agc ttt gaa aca gat atg aac cta aac ttt caa aac        720
Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn           
225                 230                 235                 240           

ctg tca gtt atg gga ctc cga atc ctc ctg ctg aaa gta gcc gga ttt        768
Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe           
                245                 250                 255               

aac ctg ctc atg acg ctg agg ctg tgg tcc agt tga                        804
Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser                               
            260                 265                                       


<210>  36
<211>  267
<212>  PRT
<213>  Mus musculus

<400>  36

Met Asn Arg Phe Leu Gly Ile Ser Leu Val Thr Leu Trp Phe Gln Val 
1               5                   10                  15      


Ala Trp Ala Lys Ser Gln Trp Gly Glu Glu Asn Leu Gln Ala Leu Ser 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Val Thr Met Asn Cys Ser Tyr Lys Thr Tyr 
        35                  40                  45              


Thr Thr Val Val Gln Trp Tyr Arg Gln Lys Ser Gly Lys Gly Pro Ala 
    50                  55                  60                  


Gln Leu Ile Leu Ile Arg Ser Asn Glu Arg Glu Lys Arg Ser Gly Arg 
65                  70                  75                  80  


Leu Arg Ala Thr Leu Asp Thr Ser Ser Gln Ser Ser Ser Leu Ser Ile 
                85                  90                  95      


Thr Gly Thr Leu Ala Thr Asp Thr Ala Val Tyr Phe Cys Ala Thr Gly 
            100                 105                 110         


Pro Asn Thr Asn Lys Val Val Phe Gly Thr Gly Thr Arg Leu Gln Val 
        115                 120                 125             


Leu Pro Asn Ile Gln Asn Pro Glu Pro Ala Val Tyr Gln Leu Lys Asp 
    130                 135                 140                 


Pro Arg Ser Gln Asp Ser Thr Leu Cys Leu Phe Thr Asp Phe Asp Ser 
145                 150                 155                 160 


Gln Ile Asn Val Pro Lys Thr Met Glu Ser Gly Thr Phe Ile Thr Asp 
                165                 170                 175     


Lys Thr Val Leu Asp Met Lys Ala Met Asp Ser Lys Ser Asn Gly Ala 
            180                 185                 190         


Ile Ala Trp Ser Asn Gln Thr Ser Phe Thr Cys Gln Asp Ile Phe Lys 
        195                 200                 205             


Glu Thr Asn Ala Thr Tyr Pro Ser Ser Asp Val Pro Cys Asp Ala Thr 
    210                 215                 220                 


Leu Thr Glu Lys Ser Phe Glu Thr Asp Met Asn Leu Asn Phe Gln Asn 
225                 230                 235                 240 


Leu Ser Val Met Gly Leu Arg Ile Leu Leu Leu Lys Val Ala Gly Phe 
                245                 250                 255     


Asn Leu Leu Met Thr Leu Arg Leu Trp Ser Ser 
            260                 265         


<210>  37
<211>  909
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(909)

<400>  37
atg agc tgc agg ctt ctc ctc tat gtt tcc cta tgt ctt gtg gaa aca         48
Met Ser Cys Arg Leu Leu Leu Tyr Val Ser Leu Cys Leu Val Glu Thr           
1               5                   10                  15                

gca ctc atg aac act aaa att act cag tca cca aga tat cta atc ctg         96
Ala Leu Met Asn Thr Lys Ile Thr Gln Ser Pro Arg Tyr Leu Ile Leu           
            20                  25                  30                    

gga aga gca aat aag tct ttg gaa tgt gag caa cat ctg gga cat aat        144
Gly Arg Ala Asn Lys Ser Leu Glu Cys Glu Gln His Leu Gly His Asn           
        35                  40                  45                        

gct atg tac tgg tat aaa cag agc gct gag aag ccg cca gag ctc atg        192
Ala Met Tyr Trp Tyr Lys Gln Ser Ala Glu Lys Pro Pro Glu Leu Met           
    50                  55                  60                            

ttt ctc tac aat ctt aaa cag ttg att cga aat gag acg gtg ccc agt        240
Phe Leu Tyr Asn Leu Lys Gln Leu Ile Arg Asn Glu Thr Val Pro Ser           
65                  70                  75                  80            

cgt ttt ata cct gaa tgc cca gac agc tcc aag cta ctt tta cat ata        288
Arg Phe Ile Pro Glu Cys Pro Asp Ser Ser Lys Leu Leu Leu His Ile           
                85                  90                  95                

tct gcc gtg gat cca gaa gac tca gct gtc tat ttt tgt gcc agc agc        336
Ser Ala Val Asp Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser           
            100                 105                 110                   

caa ggt ggt gct gag cag ttc ttc gga cca ggg aca cga ctc acc gtc        384
Gln Gly Gly Ala Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val           
        115                 120                 125                       

cta gag gat ctg aga aat gtg act cca ccc aag gtc tcc ttg ttt gag        432
Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu           
    130                 135                 140                           

cca tca aaa gca gag att gca aac aaa caa aag gct acc ctc gtg tgc        480
Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys           
145                 150                 155                 160           

ttg gcc agg ggc ttc ttc cct gac cac gtg gag ctg agc tgg tgg gtg        528
Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val           
                165                 170                 175               

aat ggc aag gag gtc cac agt ggg gtc agc acg gac cct cag gcc tac        576
Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr           
            180                 185                 190                   

aag gag agc aat tat agc tac tgc ctg agc agc cgc ctg agg gtc tct        624
Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser           
        195                 200                 205                       

gct acc ttc tgg cac aat cct cga aac cac ttc cgc tgc caa gtg cag        672
Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln           
    210                 215                 220                           

ttc cat ggg ctt tca gag gag gac aag tgg cca gag ggc tca ccc aaa        720
Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys           
225                 230                 235                 240           

cct gtc aca cag aac atc agt gca gag gcc tgg ggc cga gca gac tgt        768
Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys           
                245                 250                 255               

gga atc act tca gca tcc tat cat cag ggg gtt ctg tct gca acc atc        816
Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile           
            260                 265                 270                   

ctc tat gag atc cta ctg ggg aag gcc acc cta tat gct gtg ctg gtc        864
Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val           
        275                 280                 285                       

agt ggc ctg gtg ctg atg gcc atg gtc aag aaa aaa aat tcc tag            909
Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser                   
    290                 295                 300                           


<210>  38
<211>  302
<212>  PRT
<213>  Mus musculus

<400>  38

Met Ser Cys Arg Leu Leu Leu Tyr Val Ser Leu Cys Leu Val Glu Thr 
1               5                   10                  15      


Ala Leu Met Asn Thr Lys Ile Thr Gln Ser Pro Arg Tyr Leu Ile Leu 
            20                  25                  30          


Gly Arg Ala Asn Lys Ser Leu Glu Cys Glu Gln His Leu Gly His Asn 
        35                  40                  45              


Ala Met Tyr Trp Tyr Lys Gln Ser Ala Glu Lys Pro Pro Glu Leu Met 
    50                  55                  60                  


Phe Leu Tyr Asn Leu Lys Gln Leu Ile Arg Asn Glu Thr Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ile Pro Glu Cys Pro Asp Ser Ser Lys Leu Leu Leu His Ile 
                85                  90                  95      


Ser Ala Val Asp Pro Glu Asp Ser Ala Val Tyr Phe Cys Ala Ser Ser 
            100                 105                 110         


Gln Gly Gly Ala Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val 
        115                 120                 125             


Leu Glu Asp Leu Arg Asn Val Thr Pro Pro Lys Val Ser Leu Phe Glu 
    130                 135                 140                 


Pro Ser Lys Ala Glu Ile Ala Asn Lys Gln Lys Ala Thr Leu Val Cys 
145                 150                 155                 160 


Leu Ala Arg Gly Phe Phe Pro Asp His Val Glu Leu Ser Trp Trp Val 
                165                 170                 175     


Asn Gly Lys Glu Val His Ser Gly Val Ser Thr Asp Pro Gln Ala Tyr 
            180                 185                 190         


Lys Glu Ser Asn Tyr Ser Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
        195                 200                 205             


Ala Thr Phe Trp His Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
    210                 215                 220                 


Phe His Gly Leu Ser Glu Glu Asp Lys Trp Pro Glu Gly Ser Pro Lys 
225                 230                 235                 240 


Pro Val Thr Gln Asn Ile Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
                245                 250                 255     


Gly Ile Thr Ser Ala Ser Tyr His Gln Gly Val Leu Ser Ala Thr Ile 
            260                 265                 270         


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
        275                 280                 285             


Ser Gly Leu Val Leu Met Ala Met Val Lys Lys Lys Asn Ser 
    290                 295                 300         


<210>  39
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Artificially synthesized oligonucleotide primer

<400>  39
actggaccac agcctcagcg tcat                                              24


<210>  40
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Artificially synthesized oligonucleotide primer

<400>  40
tgaattcttt cttttgacca tagccat                                           27


<210>  41
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Artificially synthesized oligonucleotide primer

<400>  41
ggaatttttt ttcttgacca tggccat                                           27


<210>  42
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Artificially synthesized oligonucleotide primer

<400>  42
taatacgact cactataggg agagccacca tgctcctggc actcctccc                   49


<210>  43
<211>  89
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Artificially synthesized oligonucleotide primer

<400>  43
tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt       60

ttttttaact ggaccacagc ctcagcgtc                                         89


<210>  44
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Artificially synthesized oligonucleotide primer

<400>  44
taatacgact cactataggg agagccacca tgggcaccag gcttcttgg                   49


<210>  45
<211>  92
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Artificially synthesized oligonucleotide primer

<400>  45
tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt       60

ttttttagga attttttttc ttgaccatgg cc                                     92


<210>  46
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Artificially synthesized oligonucleotide primer

<400>  46
taatacgact cactataggg agagccacca tgaagacagt gactggacc                   49


<210>  47
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Artificially synthesized oligonucleotide primer

<400>  47
taatacgact cactataggg agagccacca tgtctaacac tgccttccct                  50


<210>  48
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized oligonucleotide primer

<400>  48
taatacgact cactataggg agagccacca tgggctccag actcttcttt                  50


<210>  49
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized oligonucleotide primer

<400>  49
taatacgact cactataggg agagccacca tgtctaacac tgtcctcgct                  50


<210>  50
<211>  99
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized oligonucleotide primer

<400>  50
tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt tttttttttt       60

ttttttctat gaattctttc ttttgaccat agccatcac                              99


<210>  51
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized oligonucleotide primer

<400>  51
taatacgact cactataggg agagccacca tgaagaggct gctgtgttct                  50


<210>  52
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized oligonucleotide primer

<400>  52
taatacgact cactataggg agagccacca tgagctgcag gcttctc                     47


<210>  53
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificially synthesized oligonucleotide primer

<400>  53
taatacgact cactataggg agagccacca tgaacagatt cctgggaata tc               52


<210>  54
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artifically synthesized peptide

<400>  54

Leu Leu Trp Asn Gly Pro Met Ala Val 
1               5                   


<210>  55
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artifically synthesized peptide

<400>  55

Gly Ile Leu Gly Phe Val Phe Thr Leu 
1               5                   


