                               SEQUENCE LISTING

<110> THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
 
<120> CIRCULATING KIM-1 LEVELS FOR DETECTION OF PATHOLOGIES ASSOCIATED 
      WITH INJURY TO, OR CANCER OF, THE KIDNEY

<130> 043214-081461-PCT

<140> PCT/US2015/25746
<141> 2015-04-14

<150> 61/979,587
<151> 2014-04-15

<160> 7     

<170> PatentIn version 3.5

<210> 1
<211> 364
<212> PRT
<213> Homo sapiens

<400> 1
Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly Ile Tyr Ala Gly Val Cys Ile Ser Val 
    290                 295                 300                 


Leu Val Leu Leu Ala Leu Leu Gly Val Ile Ile Ala Lys Lys Tyr Phe 
305                 310                 315                 320 


Phe Lys Lys Glu Val Gln Gln Leu Ser Val Ser Phe Ser Ser Leu Gln 
                325                 330                 335     


Ile Lys Ala Leu Gln Asn Ala Val Glu Lys Glu Val Gln Ala Glu Asp 
            340                 345                 350         


Asn Ile Tyr Ile Glu Asn Ser Leu Tyr Ala Thr Asp 
        355                 360                 


<210> 2
<211> 1841
<212> DNA
<213> Homo sapiens

<400> 2
attctcctgc ctcagcctcc cgagtagctg ggactacagg cgccagtgac cacgcccggc       60

taattttttg tatttttagt agagacgggg tttcaccctt ttagccagga tggtctcgat      120

ctcctgactt cgtgatctgc ccgccttggc ctcccaaagt gctaggatta caggtttgag      180

ccaccgcgcc cggccctgtt tcctttttgt ttgttcccct gataccctgt atcaggacca      240

ggagtcagtt tggcggttat gtgtggggaa gaagctggga agtcaggggc tgtttctgtg      300

gacagctttc cctgtccttt ggaaggcaca gagctctcag ctgcagggaa ctaacagagc      360

tctgaagccg ttatatgtgg tcttctctca tttccagcag agcaggctca tatgaatcaa      420

ccaactgggt gaaaagataa gttgcaatct gagatttaag acttgatcag ataccatctg      480

gtggagggta ccaaccagcc tgtctgctca ttttccttca ggctgatccc ataatgcatc      540

ctcaagtggt catcttaagc ctcatcctac atctggcaga ttctgtagct ggttctgtaa      600

aggttggtgg agaggcaggt ccatctgtca cactaccctg ccactacagt ggagctgtca      660

catccatgtg ctggaataga ggctcatgtt ctctattcac atgccaaaat ggcattgtct      720

ggaccaatgg aacccacgtc acctatcgga aggacacacg ctataagcta ttgggggacc      780

tttcaagaag ggatgtctct ttgaccatag aaaatacagc tgtgtctgac agtggcgtat      840

attgttgccg tgttgagcac cgtgggtggt tcaatgacat gaaaatcacc gtatcattgg      900

agattgtgcc acccaaggtc acgactactc caattgtcac aactgttcca accgtcacga      960

ctgttcgaac gagcaccact gttccaacga caacgactgt tccaatgacg actgttccaa     1020

cgacaactgt tccaacaaca atgagcattc caacgacaac gactgttctg acgacaatga     1080

ctgtttcaac gacaacgagc gttccaacga caacgagcat tccaacaaca acaagtgttc     1140

cagtgacaac aactgtctct acctttgttc ctccaatgcc tttgcccagg cagaaccatg     1200

aaccagtagc cacttcacca tcttcacctc agccagcaga aacccaccct acgacactgc     1260

agggagcaat aaggagagaa cccaccagct caccattgta ctcttacaca acagatggga     1320

atgacaccgt gacagagtct tcagatggcc tttggaataa caatcaaact caactgttcc     1380

tagaacatag tctactgacg gccaatacca ctaaaggaat ctatgctgga gtctgtattt     1440

ctgtcttggt gcttcttgct cttttgggtg tcatcattgc caaaaagtat ttcttcaaaa     1500

aggaggttca acaactaagt gtttcattta gcagccttca aattaaagct ttgcaaaatg     1560

cagttgaaaa ggaagtccaa gcagaagaca atatctacat tgagaatagt ctttatgcca     1620

cggactaaga cccagtggtg ctctttgaga gtttacgccc atgagtgcag aagactgaac     1680

agacatcagc acatcagacg tcttttagac cccaagacaa tttttctgtt tcagtttcat     1740

ctggcattcc aacatgtcag tgatactggg tagagtaact ctctcactcc aaactgtgta     1800

tagtcaacct catcattaat gtagtcctaa ttttttatgc t                         1841


<210> 3
<211> 1493
<212> DNA
<213> Homo sapiens

<400> 3
attctcctgc ctcagcctcc cgagtagctg ggactacagg cgccagtgac cacgcccggc       60

taattttttg tatttttagt agagacgggg tttcaccctt ttagccagga tggtctcgat      120

ctcctgactt cgtgatctgc ccgccttggc ctcccaaagt gctaggatta caggctgatc      180

ccataatgca tcctcaagtg gtcatcttaa gcctcatcct acatctggca gattctgtag      240

ctggttctgt aaaggttggt ggagaggcag gtccatctgt cacactaccc tgccactaca      300

gtggagctgt cacatccatg tgctggaata gaggctcatg ttctctattc acatgccaaa      360

atggcattgt ctggaccaat ggaacccacg tcacctatcg gaaggacaca cgctataagc      420

tattggggga cctttcaaga agggatgtct ctttgaccat agaaaataca gctgtgtctg      480

acagtggcgt atattgttgc cgtgttgagc accgtgggtg gttcaatgac atgaaaatca      540

ccgtatcatt ggagattgtg ccacccaagg tcacgactac tccaattgtc acaactgttc      600

caaccgtcac gactgttcga acgagcacca ctgttccaac gacaacgact gttccaatga      660

cgactgttcc aacgacaact gttccaacaa caatgagcat tccaacgaca acgactgttc      720

tgacgacaat gactgtttca acgacaacga gcgttccaac gacaacgagc attccaacaa      780

caacaagtgt tccagtgaca acaactgtct ctacctttgt tcctccaatg cctttgccca      840

ggcagaacca tgaaccagta gccacttcac catcttcacc tcagccagca gaaacccacc      900

ctacgacact gcagggagca ataaggagag aacccaccag ctcaccattg tactcttaca      960

caacagatgg gaatgacacc gtgacagagt cttcagatgg cctttggaat aacaatcaaa     1020

ctcaactgtt cctagaacat agtctactga cggccaatac cactaaagga atctatgctg     1080

gagtctgtat ttctgtcttg gtgcttcttg ctcttttggg tgtcatcatt gccaaaaagt     1140

atttcttcaa aaaggaggtt caacaactaa gtgtttcatt tagcagcctt caaattaaag     1200

ctttgcaaaa tgcagttgaa aaggaagtcc aagcagaaga caatatctac attgagaata     1260

gtctttatgc cacggactaa gacccagtgg tgctctttga gagtttacgc ccatgagtgc     1320

agaagactga acagacatca gcacatcaga cgtcttttag accccaagac aatttttctg     1380

tttcagtttc atctggcatt ccaacatgtc agtgatactg ggtagagtaa ctctctcact     1440

ccaaactgtg tatagtcaac ctcatcatta atgtagtcct aattttttat gct            1493


<210> 4
<211> 1359
<212> DNA
<213> Homo sapiens

<400> 4
gttacccagc attgtgagtg acagagcctg gatctgaacg ctgatcccat aatgcatcct       60

caagtggtca tcttaagcct catcctacat ctggcagatt ctgtagctgg ttctgtaaag      120

gttggtggag aggcaggtcc atctgtcaca ctaccctgcc actacagtgg agctgtcaca      180

tccatgtgct ggaatagagg ctcatgttct ctattcacat gccaaaatgg cattgtctgg      240

accaatggaa cccacgtcac ctatcggaag gacacacgct ataagctatt gggggacctt      300

tcaagaaggg atgtctcttt gaccatagaa aatacagctg tgtctgacag tggcgtatat      360

tgttgccgtg ttgagcaccg tgggtggttc aatgacatga aaatcaccgt atcattggag      420

attgtgccac ccaaggtcac gactactcca attgtcacaa ctgttccaac cgtcacgact      480

gttcgaacga gcaccactgt tccaacgaca acgactgttc caatgacgac tgttccaacg      540

acaactgttc caacaacaat gagcattcca acgacaacga ctgttctgac gacaatgact      600

gtttcaacga caacgagcgt tccaacgaca acgagcattc caacaacaac aagtgttcca      660

gtgacaacaa ctgtctctac ctttgttcct ccaatgcctt tgcccaggca gaaccatgaa      720

ccagtagcca cttcaccatc ttcacctcag ccagcagaaa cccaccctac gacactgcag      780

ggagcaataa ggagagaacc caccagctca ccattgtact cttacacaac agatgggaat      840

gacaccgtga cagagtcttc agatggcctt tggaataaca atcaaactca actgttccta      900

gaacatagtc tactgacggc caataccact aaaggaatct atgctggagt ctgtatttct      960

gtcttggtgc ttcttgctct tttgggtgtc atcattgcca aaaagtattt cttcaaaaag     1020

gaggttcaac aactaagtgt ttcatttagc agccttcaaa ttaaagcttt gcaaaatgca     1080

gttgaaaagg aagtccaagc agaagacaat atctacattg agaatagtct ttatgccacg     1140

gactaagacc cagtggtgct ctttgagagt ttacgcccat gagtgcagaa gactgaacag     1200

acatcagcac atcagacgtc ttttagaccc caagacaatt tttctgtttc agtttcatct     1260

ggcattccaa catgtcagtg atactgggta gagtaactct ctcactccaa actgtgtata     1320

gtcaacctca tcattaatgt agtcctaatt ttttatgct                            1359


<210> 5
<211> 18
<212> PRT
<213> Homo sapiens

<400> 5
Ser Ser Asp Gly Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu 
1               5                   10                  15      


His Ser 
        


<210> 6
<211> 295
<212> PRT
<213> Homo sapiens

<400> 6
Met His Pro Gln Val Val Ile Leu Ser Leu Ile Leu His Leu Ala Asp 
1               5                   10                  15      


Ser Val Ala Gly Ser Val Lys Val Gly Gly Glu Ala Gly Pro Ser Val 
            20                  25                  30          


Thr Leu Pro Cys His Tyr Ser Gly Ala Val Thr Ser Met Cys Trp Asn 
        35                  40                  45              


Arg Gly Ser Cys Ser Leu Phe Thr Cys Gln Asn Gly Ile Val Trp Thr 
    50                  55                  60                  


Asn Gly Thr His Val Thr Tyr Arg Lys Asp Thr Arg Tyr Lys Leu Leu 
65                  70                  75                  80  


Gly Asp Leu Ser Arg Arg Asp Val Ser Leu Thr Ile Glu Asn Thr Ala 
                85                  90                  95      


Val Ser Asp Ser Gly Val Tyr Cys Cys Arg Val Glu His Arg Gly Trp 
            100                 105                 110         


Phe Asn Asp Met Lys Ile Thr Val Ser Leu Glu Ile Val Pro Pro Lys 
        115                 120                 125             


Val Thr Thr Thr Pro Ile Val Thr Thr Val Pro Thr Val Thr Thr Val 
    130                 135                 140                 


Arg Thr Ser Thr Thr Val Pro Thr Thr Thr Thr Val Pro Met Thr Thr 
145                 150                 155                 160 


Val Pro Thr Thr Thr Val Pro Thr Thr Met Ser Ile Pro Thr Thr Thr 
                165                 170                 175     


Thr Val Leu Thr Thr Met Thr Val Ser Thr Thr Thr Ser Val Pro Thr 
            180                 185                 190         


Thr Thr Ser Ile Pro Thr Thr Thr Ser Val Pro Val Thr Thr Thr Val 
        195                 200                 205             


Ser Thr Phe Val Pro Pro Met Pro Leu Pro Arg Gln Asn His Glu Pro 
    210                 215                 220                 


Val Ala Thr Ser Pro Ser Ser Pro Gln Pro Ala Glu Thr His Pro Thr 
225                 230                 235                 240 


Thr Leu Gln Gly Ala Ile Arg Arg Glu Pro Thr Ser Ser Pro Leu Tyr 
                245                 250                 255     


Ser Tyr Thr Thr Asp Gly Asn Asp Thr Val Thr Glu Ser Ser Asp Gly 
            260                 265                 270         


Leu Trp Asn Asn Asn Gln Thr Gln Leu Phe Leu Glu His Ser Leu Leu 
        275                 280                 285             


Thr Ala Asn Thr Thr Lys Gly 
    290                 295 


<210> 7
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Cys Cys Cys Cys 
1               


