                         SEQUENCE LISTING

<110>  The Regents of the University of California
       HAUSNER, Sven H.
       SUTCLIFFE, Julie L.
 
<120>  BI-TERMINAL PEGYLATED INTEGRIN-BINDING PEPTIDES AND METHODS OF 
       USE THEREOF

<130>  76916-937662

<140>  WO PCT/US2015/025700
<141>  2015-04-14

<150>  US 61/979,997
<151>  2014-04-15

<160>  52    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic amino acid sequence


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  X is hydroxyproline

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is hydroxyproline

<400>  1

Gly Phe Xaa Gly Glu Arg 
1               5       


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic alpha-five beta-six integrin-binding peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Leu or Ile

<400>  2

Arg Asp Gly Leu Xaa Xaa Xaa 
1               5           


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic alpha-five beta-six integrin-binding peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Leu or Ile

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Lys or Arg

<400>  3

Arg Asp Gly Leu Xaa Xaa Xaa Ala Gln Xaa 
1               5                   10  


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic alpha-five beta-six integrin-binging protein


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is absent or any amino acid

<400>  4

Arg Ser Asp Leu Thr Pro Leu Phe Xaa 
1               5                   


<210>  5
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic alpha-five beta-six integrin-binding protein A20FMDV2 
       or A20FMDV2 K16R


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Lys (A20FMDV2) or Arg (A20FMDV2 K16R)

<400>  5

Asn Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Xaa 
1               5                   10                  15      


Val Ala Arg Thr 
            20  


<210>  6
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic proapoptotic heptapeptide dimer

<400>  6

Lys Leu Ala Lys Leu Ala Lys Lys Leu Ala Lys Leu Ala Lys 
1               5                   10                  


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic alpha-five beta-six integrin-binding peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is Glu, Ala, Leu, Met, Gln, Lys, Arg, Val, Ile, His, Thr, 
       Trp, Phe or Asp

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Leu or Ile

<400>  7

Arg Gly Asp Leu Xaa Xaa Xaa 
1               5           


<210>  8
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic alpha-helix peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Leu or Ile

<400>  8

Leu Xaa Xaa Xaa 
1               


<210>  9
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic alpha-five beta-six integrin-binding peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Xaa is Glu, Ala, Leu, Met, Gln, Lys, Arg, Val, Ile, His, Thr, 
       Trp, Phe or Asp

<220>
<221>  MISC_FEATURE
<222>  (8)..(10)
<223>  Xaa is Glu, Ala, Leu, Met, Gln, Lys, Arg, Val, Ile, His, Thr, 
       Trp, Phe or Asp

<220>
<221>  MISC_FEATURE
<222>  (11)..(30)
<223>  Xaa is 1 to 20 amino acids; 19 may be present or absent

<220>
<221>  MISC_FEATURE
<222>  (11)..(30)
<223>  Xaa is a helix-promoting amino acid

<400>  9

Arg Asp Gly Leu Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30  


<210>  10
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic alpha-five beta-six integrin-binding peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(35)
<223>  Xaa is 1 to 35 amino acids, 34 amino acids may be present or 
       absent

<220>
<221>  MISC_FEATURE
<222>  (1)..(35)
<223>  Xaa is amino acids which enhance hydrophobic interactions with 
       the helix LXXL and enhance RDG domain for binding

<220>
<221>  MISC_FEATURE
<222>  (40)..(41)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (43)..(45)
<223>  Xaa is any amino acid

<220>
<221>  MISC_FEATURE
<222>  (46)..(80)
<223>  Xaa is 1 to 35 amino acids, 34 amino acids may be present or 
       absent

<220>
<221>  MISC_FEATURE
<222>  (46)..(80)
<223>  Xaa is a helix-promoting amino acid

<400>  10

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Arg Gly Asp Leu Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic alpha-five beta-six integrin binding peptide (A20LAP)

<400>  11

Gly Phe Thr Thr Gly Arg Arg Gly Asp Leu Ala Thr Ile His Gly Met 
1               5                   10                  15      


Asn Arg Pro Phe 
            20  


<210>  12
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic alpha-five beta-six integrin-binding protein (A20FMDV1)

<400>  12

Tyr Thr Ala Ser Ala Arg Gly Asp Leu Ala His Leu Thr Thr Thr His 
1               5                   10                  15      


Ala Arg His Leu 
            20  


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide FBA-PEG28-A20FMVDV2-PEG28 imaging probe with 
       A20FMVDV2 (SEQ ID NO:5) core


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorobenzoic acid (FBA) linked to polyethylene glycol 
       (PEG)28 conjugated to Asn

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Lys or Arg

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Thr conjugated to polyethylene glycol (PEG)28

<400>  13

Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Xaa 
1               5                   10                  15      


Val Ala Arg Xaa 
            20  


<210>  14
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic 18F-FBA-A20FMVDV2 imaging probe with A20FMVDV2 (SEQ ID 
       NO:5) core


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorine-18 (radio)labeled fluorobenzoic acid (FBA) 
       conjugated to Asn

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Lys or Arg

<400>  14

Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Xaa 
1               5                   10                  15      


Val Ala Arg Thr 
            20  


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide 18F-FBA-PEG28-A20FMVDV2 imaging probe with 
       A20FMVDV2 (SEQ ID NO:5) core


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorine-18 (radio)labeled fluorobenzoic acid (FBA) linked
       to polyethylene glycol (PEG)28 conjugated to Asn

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Lys or Arg

<400>  15

Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Xaa 
1               5                   10                  15      


Val Ala Arg Thr 
            20  


<210>  16
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide 18F-FBA-(PEG28)2-A20FMVDV2 imaging probe with 
       A20FMVDV2 (SEQ ID NO:5) core


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorine-18 (radio)labeled fluorobenzoic acid (FBA) linked
       to 2 polyethylene glycol (PEG)28 units conjugated to Asn

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Lys or Arg

<400>  16

Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Xaa 
1               5                   10                  15      


Val Ala Arg Thr 
            20  


<210>  17
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide FBA-A20FMVDV2-PEG28- imaging probe with 
       A20FMVDV2 (SEQ ID NO:5) core


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorobenzoic acid (FBA) conjugated to Asn

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Lys or Arg

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Thr conjugated to polyethylene glycol (PEG)28

<400>  17

Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Xaa 
1               5                   10                  15      


Val Ala Arg Xaa 
            20  


<210>  18
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide 18F-FBA-A20FMVDV2-PEG28 imaging probe with 
       A20FMVDV2 (SEQ ID NO:5) core


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorine-18 (radio)labeled fluorobenzoic acid (FBA) 
       conjugated to Asn

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Lys or Arg

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Thr conjugated to polyethylene glycol (PEG)28

<400>  18

Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Xaa 
1               5                   10                  15      


Val Ala Arg Xaa 
            20  


<210>  19
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide 18F-FBA-PEG28-A20FMVDV2-PEG28 imaging probe 
       with A20FMVDV2 (SEQ ID NO:5) core


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorine-18 (radio)labeled fluorobenzoic acid (FBA) linked
       to polyethylene glycol (PEG)28 conjugated to Asn

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Lys or Arg

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Thr conjugated to polyethylene glycol (PEG)28

<400>  19

Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Xaa 
1               5                   10                  15      


Val Ala Arg Xaa 
            20  


<210>  20
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide FBA-PEG28-A20FMVDV2 imaging probe with 
       A20FMVDV2 (SEQ ID NO:5) core


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorobenzoic acid (FBA) linked to polyethylene glycol 
       (PEG)28 conjugated to Asn

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Lys or Arg

<400>  20

Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Xaa 
1               5                   10                  15      


Val Ala Arg Thr 
            20  


<210>  21
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide PEG28-A20FMVDV2 K16R-PEG28 imaging probe with 
       A20FMVDV2 K16R (SEQ ID NO:5) core


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is polyethylene glycol (PEG)28 conjugated to Asn

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Lys or Arg

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Thr conjugated to polyethylene glycol (PEG)28

<400>  21

Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Xaa 
1               5                   10                  15      


Val Ala Arg Xaa 
            20  


<210>  22
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide D(KLAKLAK)2-GG-PEG28-A20FMVDV2 K16R-PEG28 with 
       A20FMVDV2 K16R (SEQ ID NO:5) core


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Gly-Gly (GG) linker

<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  Gly-Gly (GG) linker

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Gly linked to PEG28

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Xaa is polyethylene glycol (PEG)28 conjugated to Asn

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  Xaa is Lys or Arg

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  Xaa is Thr conjugated to polyethylene glycol (PEG)28

<400>  22

Lys Leu Ala Lys Leu Ala Lys Lys Leu Ala Lys Leu Ala Lys Gly Xaa 
1               5                   10                  15      


Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Xaa 
            20                  25                  30          


Val Ala Arg Xaa 
        35      


<210>  23
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide PEG28-A20MFDV2-GG-D(KLAKLAK)2-K


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is polyethylene glycol (PEG)28 conjugated to Asn

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  Gly-Gly (GG) linker

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Lys linked to terminal Lys

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Lys linked to terminal Lys at position 37

<400>  23

Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Lys 
1               5                   10                  15      


Val Ala Arg Thr Gly Gly Lys Leu Ala Lys Leu Ala Lys Lys Leu Ala 
            20                  25                  30          


Lys Leu Ala Lys Lys 
        35          


<210>  24
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide D(KLAKLAK)2-GG-PEG28-A20FMVDV2-K


<220>
<221>  MISC_FEATURE
<222>  (15)..(16)
<223>  Gly-Gly (GG) linker

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Gly linked to PEG28

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Xaa is polyethylene glycol (PEG)28 conjugated to Asn

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Thr linked to terminal Lys

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Thr linked to terminal Lys at position 37

<400>  24

Lys Leu Ala Lys Leu Ala Lys Lys Leu Ala Lys Leu Ala Lys Gly Xaa 
1               5                   10                  15      


Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Lys 
            20                  25                  30          


Val Ala Arg Thr Lys 
        35          


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide 90Y-DOTA-PEG28-A20FMVDV2(K16R)-PEG28


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is yttrium 90 (radio)labeled 
       1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) 
       linked to polyethylene glycol (PEG)28 conjugated to Asn

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Thr conjugated to polyethylene glycol (PEG)28

<400>  25

Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Lys 
1               5                   10                  15      


Val Ala Arg Xaa 
            20  


<210>  26
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide DOTA-PEG28-A20FMVDV2(K16R)-PEG28


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid 
       (DOTA) linked to polyethylene glycol (PEG)28 conjugated to Asn

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Thr conjugated to polyethylene glycol (PEG)28

<400>  26

Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Lys 
1               5                   10                  15      


Val Ala Arg Xaa 
            20  


<210>  27
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide PEG28-A20FMDV2(K16R)-PEG28-PEG5K-CA8-PTX


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is polyethylene glycol (PEG)28 conjugated to Asn

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Thr conjugated to polyethylene glycol (PEG)28 conjugated 
       to polyethylene glycol (PEG5000) cholic acid (CA8) loaded with 
       paclitaxel (PTX)

<400>  27

Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Lys 
1               5                   10                  15      


Val Ala Arg Xaa 
            20  


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide alkynyl-PEG28-A20FMDV2(K16R)-PEG28


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is alkynyl linked polyethylene glycol (PEG)28 conjugated to 
       Asn

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa Xaa is Thr conjugated to polyethylene glycol (PEG)28

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Thr conjugated to polyethylene glycol (PEG)28

<400>  28

Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Lys 
1               5                   10                  15      


Val Ala Arg Xaa 
            20  


<210>  29
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide PEG28-A20FMDV2(K16R)-PEG28-PEG5K-CA8


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is polyethylene glycol (PEG)28 conjugated to Asn

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Thr conjugated to polyethylene glycol (PEG)28 conjugated 
       to polyethylene glycol (PEG5000) cholic acid (CA8)

<400>  29

Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Lys 
1               5                   10                  15      


Val Ala Arg Xaa 
            20  


<210>  30
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide FBA-K(IPA)E-PEG28-NAVPNLRGDLQVLAQKVART-PEG28


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorobenzoic acid (FBA) linked to epsilon-(4-(4- 
       iodophenyl)butyl amide)lysine-glutamic acid) polyethylene glycol 
       (PEG)28 conjugated to Asn

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Thr conjugated to polyethylene glycol (PEG)28

<400>  30

Xaa Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Lys 
1               5                   10                  15      


Val Ala Arg Xaa 
            20  


<210>  31
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide Boc-RSDLTPLFK(NH2)-NH2


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is tert-butyloxycarbonyl (Boc) conjugated to Arg

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Lys linked to a free N-terminal amine

<400>  31

Xaa Ser Asp Leu Thr Pro Leu Phe Xaa 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide RSDLTPLFK(Boc)-NH2


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Lys conjugated to tert-butyloxycarbonyl (Boc) linked to a 
       free N-terminal amine

<400>  32

Arg Ser Asp Leu Thr Pro Leu Phe Xaa 
1               5                   


<210>  33
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide PEG11-RSDLTPLF-NH2


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is polyethylene glycol (PEG)11 conjugated to Arg

<400>  33

Xaa Ser Asp Leu Thr Pro Leu Phe 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide RSDLTPLF- PEG11-NH2


<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is Phe conjugated to polyethylene glycol (PEG)11

<400>  34

Arg Ser Asp Leu Thr Pro Leu Xaa 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide PEG11-RSDLTPLF-PEG11-NH2


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is polyethylene glycol (PEG)11 conjugated to Arg

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is Phe conjugated to polyethylene glycol (PEG)11

<400>  35

Xaa Ser Asp Leu Thr Pro Leu Xaa 
1               5               


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide c(RSDLTPLFE)K(IvdDe)-NH2


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  residues undergo cyclization

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is Lys with protecting group 
       1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)isovaleryl (ivDde)

<400>  36

Arg Ser Asp Leu Thr Pro Leu Phe Glu Xaa 
1               5                   10  


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide 19F-FBA-RSDLTPLF


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Xaa is fluorine-19 (radio)labeled fluorobenzoic acid (FBA)
       conjugated to Arg

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorine-19 (radio)labeled fluorobenzoic acid (FBA) 
       conjugated to Arg

<400>  37

Xaa Ser Asp Leu Thr Pro Leu Phe 
1               5               


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide Boc-RSDLTPLFK(19F-FBA)-NH2


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is tert-butyloxycarbonyl (Boc) conjugated to Arg

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Lys conjugated fluorine-19 (radio)labeled fluorobenzoic 
       acid (FBA) linked to a free N-terminal amine

<400>  38

Xaa Ser Asp Leu Thr Pro Leu Phe Xaa 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide 19F-FBA-RSDLTPLFK(Boc)NH2


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorine-19 (radio)labeled fluorobenzoic acid (FBA) 
       conjugated to Arg

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Lys with protecting group tert-butyloxycarbonyl (Boc) 
       linked to a free N-terminal amine

<400>  39

Xaa Ser Asp Leu Thr Pro Leu Phe Xaa 
1               5                   


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide 19F-FBA-(PEG)11-RSDLTPLF-(PEG)11-NH2


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorine-19 (radio)labeled fluorobenzoic acid (FBA) 
       conjugated to polyethylene glycol (PEG)11 conjugated to Arg

<400>  40

Xaa Ser Asp Leu Thr Pro Leu Phe 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide 19F-FBA-RSDLTPLF-(PEG)11-NH2


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorine-19 (radio)labeled fluorobenzoic acid (FBA) 
       conjugated to Arg

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is Phe conjugated to polyethylene glycol (PEG)11

<400>  41

Xaa Ser Asp Leu Thr Pro Leu Xaa 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide 19F-FBA-PEG11-RSDLTPLF-PEG11-NH2


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorine-19 (radio)labeled fluorobenzoic acid (FBA) 
       conjugated to polyethylene glycol (PEG)11 conjugated to Arg

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is Phe conjugated to polyethylene glycol (PEG)11

<400>  42

Xaa Ser Asp Leu Thr Pro Leu Xaa 
1               5               


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide c(RSDLTPLFE)K(19F-FBA)-NH2


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  residues undergo cyclization

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is Lys linked to fluorine-19 (radio)labeled fluorobenzoic 
       acid (FBA)

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is Lys linked to fluorine-19 (radio)labeled fluorobenzoic 
       acid (FBA) linked to a free N-terminal amine

<400>  43

Arg Ser Asp Leu Thr Pro Leu Phe Glu Xaa 
1               5                   10  


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide RSDLTPLFK(19F-FBA)-NH2


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Lys conjugated fluorine-19 (radio)labeled fluorobenzoic 
       acid (FBA) linked to a free N-terminal amine

<400>  44

Arg Ser Asp Leu Thr Pro Leu Phe Xaa 
1               5                   


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide (19F-FBA)-RSDLTPLFK(NH2)-NH2


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorine-19 (radio)labeled fluorobenzoic acid (FBA) 
       conjugated to Arg

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Lys linked to a free N-terminal amine

<400>  45

Xaa Ser Asp Leu Thr Pro Leu Phe Xaa 
1               5                   


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide 18F-FBA-RSDLTPLF


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorine-18 (radio)labeled fluorobenzoic acid (FBA) 
       conjugated to Arg

<400>  46

Xaa Ser Asp Leu Thr Pro Leu Phe 
1               5               


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide RSDLTPLFK(18F-FBA)-NH2


<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Lys conjugated fluorine-18 (radio)labeled fluorobenzoic 
       acid (FBA) linked to a free N-terminal amine

<400>  47

Arg Ser Asp Leu Thr Pro Leu Phe Xaa 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide (18F-FBA)-RSDLTPLFK(NH2)-NH2


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorine-18 (radio)labeled fluorobenzoic acid (FBA) 
       conjugated to Arg

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  Xaa is Lys linked to a free N-terminal amine

<400>  48

Xaa Ser Asp Leu Thr Pro Leu Phe Xaa 
1               5                   


<210>  49
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide 18F-FBA-PEG11-RSDLTPLF-NH2


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorine-18 (radio)labeled fluorobenzoic acid (FBA) 
       conjugated to polyethylene glycol (PEG)11 conjugated to Arg

<400>  49

Xaa Ser Asp Leu Thr Pro Leu Phe 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide 18F-FBA-RSDLTPLF-(PEG)11-NH2


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorine-18 (radio)labeled fluorobenzoic acid (FBA) 
       conjugated to Arg

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is Phe conjugated to polyethylene glycol (PEG)11

<400>  50

Xaa Ser Asp Leu Thr Pro Leu Xaa 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide 18F-FBA-PEG11-RSDLTPLF-PEG11-NH2


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is fluorine-18 (radio)labeled fluorobenzoic acid (FBA) 
       conjugated to polyethylene glycol (PEG)11 conjugated to Arg

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  Xaa is Phe conjugated to polyethylene glycol (PEG)11

<400>  51

Xaa Ser Asp Leu Thr Pro Leu Xaa 
1               5               


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide c(RSDLTPLFE)K(18F-FBA)-NH2


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  residues undergo cyclization

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Xaa is Lys linked to fluorine-18 (radio)labeled fluorobenzoic 
       acid (FBA)

<400>  52

Arg Ser Asp Leu Thr Pro Leu Phe Glu Xaa 
1               5                   10  


