               SEQUENCE LISTING

<110> Medizinische Hochschule Hannover

<120> Means and methods for producing Neisseria meningitidis capsular polysaccharides of low dispersity

<130> X1467 PCT S3

<150> US61/980,819
<151> 2014-04-17

<160> 135

<170> BiSSAP 1.3

<210> 1
<211> 1635
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA CP-A/CsaB wildtyp/full-length

<400> 1
atgtttatac ttaataacag aaaatggcgt aaacttaaaa gagaccctag cgctttcttt      60

cgagatagta aatttaactt tttaagatat ttttctgcta aaaaatttgc aaagaatttt     120

aaaaattcat cacatatcca taaaactaat ataagtaaag ctcaatcaaa tatttcttca     180

accttaaaac aaaatcggaa acaagatatg ttaattccta ttaatttttt taattttgaa     240

tatatagtta aaaaacttaa caatcaaaac gcaataggtg tatatattct tccttctaat     300

cttactctta agcctgcatt atgtattcta gaatcacata aagaagactt tttaaataaa     360

tttcttctta ctatttcctc tgaaaattta aagcttcaat acaaatttaa tggacaaata     420

aaaaatccta agtccgtaaa tgaaatttgg acagatttat ttagcattgc tcatgttgac     480

atgaaactca gcacagatag aactttaagt tcatctatat ctcaattttg gttcagatta     540

gagttctgta aagaagataa ggattttatc ttatttccta cagctaacag atattctaga     600

aaactttgga agcactctat taaaaataat caattattta aagaaggcat acgaaactat     660

tcagaaatat cttcattacc ctatgaagaa gatcataatt ttgatattga tttagtattt     720

acttgggtca actcagaaga taagaattgg caagagttat ataaaaaata taagcccgac     780

tttaatagcg atgcaaccag tacatcaaga ttccttagta gagatgaatt aaaattcgca     840

ttacgctctt gggaaatgaa tggatccttc attcgaaaaa tttttattgt ctctaattgt     900

gctcccccag catggctaga tttaaataac cctaaaattc aatgggtata tcacgaagaa     960

attatgccac aaagtgccct tcctactttt agctcacatg ctattgaaac cagcttgcac    1020

catataccag gaattagtaa ctattttatt tacagcaatg acgacttcct attaactaaa    1080

ccattgaata aagacaattt cttctattcg aatggtattg caaagttaag attagaagca    1140

tggggaaatg ttaatggtga atgtactgaa ggagaacctg actacttaaa tggtgctcgc    1200

aatgcgaaca ctctcttaga aaaggaattt aaaaaattta ctactaaact acatactcac    1260

tcccctcaat ccatgagaac tgatatttta tttgagatgg aaaaaaaata tccagaagag    1320

tttaatagaa cactacataa taaattccga tctttagatg atattgcagt aacgggctat    1380

ctctatcatc attatgccct actctctgga cgagcactac aaagttctga caagacggaa    1440

cttgtacagc aaaatcatga tttcaaaaag aaactaaata atgtagtgac cttaactaaa    1500

gaaaggaatt ttgacaaact tcctttgagc gtatgtatca acgatggtgc tgatagtcac    1560

ttgaatgaag aatggaatgt tcaagttatt aagttcttag aaactctttt cccattacca    1620

tcatcatttg agaaa                                                     1635


<210> 2
<211> 1635
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA CP-A/CsaB codon optimized

<400> 2
atgttcatct tgaacaaccg caaatggcgc aaattgaagc gtgacccaag cgcgtttttt      60

cgtgacagca aattcaactt tctgcgctat ttctccgcga aaaagtttgc gaagaatttc     120

aaaaacagct cgcatatcca taaaaccaac attagcaaag cgcagtccaa tatttccagc     180

accttgaagc agaaccgtaa gcaggatatg ctgatcccga tcaatttctt taattttgag     240

tacatcgtga agaaactgaa taaccaaaac gcaatcggcg tgtacattct gccgtctaat     300

ctgaccctga aaccagcatt gtgcatcttg gagtcgcaca aagaggactt cctgaacaaa     360

tttttgttga ccattagcag cgagaacctg aaactgcagt ataagttcaa tggtcagatc     420

aaaaatccga aaagcgtgaa cgaaatctgg accgacctgt ttagcattgc tcacgtcgac     480

atgaagctga gcaccgaccg tacgctgtcc tcgtccatca gccaattttg gtttcgcctg     540

gagttctgta aagaggacaa ggacttcatc ctgtttccga cggcaaatcg ttacagccgc     600

aagctgtgga agcacagcat caaaaataat cagctgttta aggaaggtat ccgtaactac     660

agcgagatta gctcgctgcc gtacgaggaa gaccataact tcgacatcga tctggtcttt     720

acctgggtca attcggaaga caaaaactgg caggaactgt acaagaaata taagccggat     780

tttaatagcg atgccacctc gacgagccgt tttctgagcc gtgacgagct gaagtttgcg     840

ctgcgctcgt gggaaatgaa cggtagcttc atccgtaaaa tctttatcgt cagcaactgc     900

gcgccgccgg cctggctgga tctgaacaat ccgaagatcc aatgggtgta tcacgaggag     960

atcatgccac agagcgccct gccaaccttc agcagccatg ctattgagac tagcttgcat    1020

cacattccgg gcatctccaa ctacttcatc tactctaatg acgattttct gttgaccaaa    1080

ccgctgaaca aagacaactt cttttactcc aacggtattg ctaaactgcg tctggaagcc    1140

tggggtaacg ttaacggtga atgtaccgaa ggcgagccgg attacctgaa cggcgcgcgt    1200

aacgcaaata cgctgctgga gaaagagttt aaaaagttta ccaccaagct gcacacccac    1260

agcccgcaga gcatgcgtac cgacatcctg ttcgagatgg agaaaaaata cccagaagag    1320

ttcaatcgca cgctgcacaa caagttccgc agcctggatg acatcgcggt taccggctac    1380

ctgtaccatc actacgcatt gctgtctggc cgcgctctgc aatccagcga taagaccgaa    1440

ctggtccagc agaatcacga ctttaaaaag aagctgaata atgttgtcac cctgaccaaa    1500

gagcgtaact ttgataagct gccgctgagc gtttgtatta atgacggtgc agacagccac    1560

ctgaatgagg agtggaatgt gcaagttatc aaattcttgg agaccttgtt cccgttgccg    1620

agctccttcg agaaa                                                     1635


<210> 3
<211> 1425
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA deltaN69-CP-A (codon optimized) (1425)

<400> 3
ctgatcccga tcaatttctt taattttgag tacatcgtga agaaactgaa taaccaaaac      60

gcaatcggcg tgtacattct gccgtctaat ctgaccctga aaccagcatt gtgcatcttg     120

gagtcgcaca aagaggactt cctgaacaaa tttttgttga ccattagcag cgagaacctg     180

aaactgcagt ataagttcaa tggtcagatc aaaaatccga aaagcgtgaa cgaaatctgg     240

accgacctgt ttagcattgc tcacgtcgac atgaagctga gcaccgaccg tacgctgtcc     300

tcgtccatca gccaattttg gtttcgcctg gagttctgta aagaggacaa ggacttcatc     360

ctgtttccga cggcaaatcg ttacagccgc aagctgtgga agcacagcat caaaaataat     420

cagctgttta aggaaggtat ccgtaactac agcgagatta gctcgctgcc gtacgaggaa     480

gaccataact tcgacatcga tctggtcttt acctgggtca attcggaaga caaaaactgg     540

caggaactgt acaagaaata taagccggat tttaatagcg atgccacctc gacgagccgt     600

tttctgagcc gtgacgagct gaagtttgcg ctgcgctcgt gggaaatgaa cggtagcttc     660

atccgtaaaa tctttatcgt cagcaactgc gcgccgccgg cctggctgga tctgaacaat     720

ccgaagatcc aatgggtgta tcacgaggag atcatgccac agagcgccct gccaaccttc     780

agcagccatg ctattgagac tagcttgcat cacattccgg gcatctccaa ctacttcatc     840

tactctaatg acgattttct gttgaccaaa ccgctgaaca aagacaactt cttttactcc     900

aacggtattg ctaaactgcg tctggaagcc tggggtaacg ttaacggtga atgtaccgaa     960

ggcgagccgg attacctgaa cggcgcgcgt aacgcaaata cgctgctgga gaaagagttt    1020

aaaaagttta ccaccaagct gcacacccac agcccgcaga gcatgcgtac cgacatcctg    1080

ttcgagatgg agaaaaaata cccagaagag ttcaatcgca cgctgcacaa caagttccgc    1140

agcctggatg acatcgcggt taccggctac ctgtaccatc actacgcatt gctgtctggc    1200

cgcgctctgc aatccagcga taagaccgaa ctggtccagc agaatcacga ctttaaaaag    1260

aagctgaata atgttgtcac cctgaccaaa gagcgtaact ttgataagct gccgctgagc    1320

gtttgtatta atgacggtgc agacagccac ctgaatgagg agtggaatgt gcaagttatc    1380

aaattcttgg agaccttgtt cccgttgccg agctccttcg agaaa                    1425


<210> 4
<211> 1344
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA deltaN97-CP-A (1344)

<400> 4
ccttctaatc ttactcttaa gcctgcatta tgtattctag aatcacataa agaagacttt      60

ttaaataaat ttcttcttac tatttcctct gaaaatttaa agcttcaata caaatttaat     120

ggacaaataa aaaatcctaa gtccgtaaat gaaatttgga cagatttatt tagcattgct     180

catgttgaca tgaaactcag cacagataga actttaagtt catctatatc tcaattttgg     240

ttcagattag agttctgtaa agaagataag gattttatct tatttcctac agctaacaga     300

tattctagaa aactttggaa gcactctatt aaaaataatc aattatttaa agaaggcata     360

cgaaactatt cagaaatatc ttcattaccc tatgaagaag atcataattt tgatattgat     420

ttagtattta cttgggtcaa ctcagaagat aagaattggc aagagttata taaaaaatat     480

aagcccgact ttaatagcga tgcaaccagt acatcaagat tccttagtag agatgaatta     540

aaattcgcat tacgctcttg ggaaatgaat ggatccttca ttcgaaaaat ttttattgtc     600

tctaattgtg ctcccccagc atggctagat ttaaataacc ctaaaattca atgggtatat     660

cacgaagaaa ttatgccaca aagtgccctt cctactttta gctcacatgc tattgaaacc     720

agcttgcacc atataccagg aattagtaac tattttattt acagcaatga cgacttccta     780

ttaactaaac cattgaataa agacaatttc ttctattcga atggtattgc aaagttaaga     840

ttagaagcat ggggaaatgt taatggtgaa tgtactgaag gagaacctga ctacttaaat     900

ggtgctcgca atgcgaacac tctcttagaa aaggaattta aaaaatttac tactaaacta     960

catactcact cccctcaatc catgagaact gatattttat ttgagatgga aaaaaaatat    1020

ccagaagagt ttaatagaac actacataat aaattccgat ctttagatga tattgcagta    1080

acgggctatc tctatcatca ttatgcccta ctctctggac gagcactaca aagttctgac    1140

aagacggaac ttgtacagca aaatcatgat ttcaaaaaga aactaaataa tgtagtgacc    1200

ttaactaaag aaaggaattt tgacaaactt cctttgagcg tatgtatcaa cgatggtgct    1260

gatagtcact tgaatgaaga atggaatgtt caagttatta agttcttaga aactcttttc    1320

ccattaccat catcatttga gaaa                                           1344


<210> 5
<211> 1134
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA deltaN167-CP-A (1134)

<400> 5
actttaagtt catctatatc tcaattttgg ttcagattag agttctgtaa agaagataag      60

gattttatct tatttcctac agctaacaga tattctagaa aactttggaa gcactctatt     120

aaaaataatc aattatttaa agaaggcata cgaaactatt cagaaatatc ttcattaccc     180

tatgaagaag atcataattt tgatattgat ttagtattta cttgggtcaa ctcagaagat     240

aagaattggc aagagttata taaaaaatat aagcccgact ttaatagcga tgcaaccagt     300

acatcaagat tccttagtag agatgaatta aaattcgcat tacgctcttg ggaaatgaat     360

ggatccttca ttcgaaaaat ttttattgtc tctaattgtg ctcccccagc atggctagat     420

ttaaataacc ctaaaattca atgggtatat cacgaagaaa ttatgccaca aagtgccctt     480

cctactttta gctcacatgc tattgaaacc agcttgcacc atataccagg aattagtaac     540

tattttattt acagcaatga cgacttccta ttaactaaac cattgaataa agacaatttc     600

ttctattcga atggtattgc aaagttaaga ttagaagcat ggggaaatgt taatggtgaa     660

tgtactgaag gagaacctga ctacttaaat ggtgctcgca atgcgaacac tctcttagaa     720

aaggaattta aaaaatttac tactaaacta catactcact cccctcaatc catgagaact     780

gatattttat ttgagatgga aaaaaaatat ccagaagagt ttaatagaac actacataat     840

aaattccgat ctttagatga tattgcagta acgggctatc tctatcatca ttatgcccta     900

ctctctggac gagcactaca aagttctgac aagacggaac ttgtacagca aaatcatgat     960

ttcaaaaaga aactaaataa tgtagtgacc ttaactaaag aaaggaattt tgacaaactt    1020

cctttgagcg tatgtatcaa cgatggtgct gatagtcact tgaatgaaga atggaatgtt    1080

caagttatta agttcttaga aactcttttc ccattaccat catcatttga gaaa          1134


<210> 6
<211> 933
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA deltaN235-CP-A (933)

<400> 6
gatattgatt tagtatttac ttgggtcaac tcagaagata agaattggca agagttatat      60

aaaaaatata agcccgactt taatagcgat gcaaccagta catcaagatt ccttagtaga     120

gatgaattaa aattcgcatt acgctcttgg gaaatgaatg gatccttcat tcgaaaaatt     180

tttattgtct ctaattgtgc tcccccagca tggctagatt taaataaccc taaaattcaa     240

tgggtatatc acgaagaaat tatgccacaa agtgcccttc ctacttttag ctcacatgct     300

attgaaacca gcttgcacca tataccagga attagtaact attttattta cagcaatgac     360

gacttcctat taactaaacc attgaataaa gacaatttct tctattcgaa tggtattgca     420

aagttaagat tagaagcatg gggaaatgtt aatggtgaat gtactgaagg agaacctgac     480

tacttaaatg gtgctcgcaa tgcgaacact ctcttagaaa aggaatttaa aaaatttact     540

actaaactac atactcactc ccctcaatcc atgagaactg atattttatt tgagatggaa     600

aaaaaatatc cagaagagtt taatagaaca ctacataata aattccgatc tttagatgat     660

attgcagtaa cgggctatct ctatcatcat tatgccctac tctctggacg agcactacaa     720

agttctgaca agacggaact tgtacagcaa aatcatgatt tcaaaaagaa actaaataat     780

gtagtgacct taactaaaga aaggaatttt gacaaacttc ctttgagcgt atgtatcaac     840

gatggtgctg atagtcactt gaatgaagaa tggaatgttc aagttattaa gttcttagaa     900

actcttttcc cattaccatc atcatttgag aaa                                  933


<210> 7
<211> 1497
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA deltaC45-CP-A (1497)

<400> 7
tttatactta ataacagaaa atggcgtaaa cttaaaagag accctagcgc tttctttcga      60

gatagtaaat ttaacttttt aagatatttt tctgctaaaa aatttgcaaa gaattttaaa     120

aattcatcac atatccataa aactaatata agtaaagctc aatcaaatat ttcttcaacc     180

ttaaaacaaa atcggaaaca agatatgtta attcctatta atttttttaa ttttgaatat     240

atagttaaaa aacttaacaa tcaaaacgca ataggtgtat atattcttcc ttctaatctt     300

actcttaagc ctgcattatg tattctagaa tcacataaag aagacttttt aaataaattt     360

cttcttacta tttcctctga aaatttaaag cttcaataca aatttaatgg acaaataaaa     420

aatcctaagt ccgtaaatga aatttggaca gatttattta gcattgctca tgttgacatg     480

aaactcagca cagatagaac tttaagttca tctatatctc aattttggtt cagattagag     540

ttctgtaaag aagataagga ttttatctta tttcctacag ctaacagata ttctagaaaa     600

ctttggaagc actctattaa aaataatcaa ttatttaaag aaggcatacg aaactattca     660

gaaatatctt cattacccta tgaagaagat cataattttg atattgattt agtatttact     720

tgggtcaact cagaagataa gaattggcaa gagttatata aaaaatataa gcccgacttt     780

aatagcgatg caaccagtac atcaagattc cttagtagag atgaattaaa attcgcatta     840

cgctcttggg aaatgaatgg atccttcatt cgaaaaattt ttattgtctc taattgtgct     900

cccccagcat ggctagattt aaataaccct aaaattcaat gggtatatca cgaagaaatt     960

atgccacaaa gtgcccttcc tacttttagc tcacatgcta ttgaaaccag cttgcaccat    1020

ataccaggaa ttagtaacta ttttatttac agcaatgacg acttcctatt aactaaacca    1080

ttgaataaag acaatttctt ctattcgaat ggtattgcaa agttaagatt agaagcatgg    1140

ggaaatgtta atggtgaatg tactgaagga gaacctgact acttaaatgg tgctcgcaat    1200

gcgaacactc tcttagaaaa ggaatttaaa aaatttacta ctaaactaca tactcactcc    1260

cctcaatcca tgagaactga tattttattt gagatggaaa aaaaatatcc agaagagttt    1320

aatagaacac tacataataa attccgatct ttagatgata ttgcagtaac gggctatctc    1380

tatcatcatt atgccctact ctctggacga gcactacaaa gttctgacaa gacggaactt    1440

gtacagcaaa atcatgattt caaaaagaaa ctaaataatg tagtgacctt aactaaa       1497


<210> 8
<211> 1557
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA deltaC25-CP-A (1557)

<400> 8
tttatactta ataacagaaa atggcgtaaa cttaaaagag accctagcgc tttctttcga      60

gatagtaaat ttaacttttt aagatatttt tctgctaaaa aatttgcaaa gaattttaaa     120

aattcatcac atatccataa aactaatata agtaaagctc aatcaaatat ttcttcaacc     180

ttaaaacaaa atcggaaaca agatatgtta attcctatta atttttttaa ttttgaatat     240

atagttaaaa aacttaacaa tcaaaacgca ataggtgtat atattcttcc ttctaatctt     300

actcttaagc ctgcattatg tattctagaa tcacataaag aagacttttt aaataaattt     360

cttcttacta tttcctctga aaatttaaag cttcaataca aatttaatgg acaaataaaa     420

aatcctaagt ccgtaaatga aatttggaca gatttattta gcattgctca tgttgacatg     480

aaactcagca cagatagaac tttaagttca tctatatctc aattttggtt cagattagag     540

ttctgtaaag aagataagga ttttatctta tttcctacag ctaacagata ttctagaaaa     600

ctttggaagc actctattaa aaataatcaa ttatttaaag aaggcatacg aaactattca     660

gaaatatctt cattacccta tgaagaagat cataattttg atattgattt agtatttact     720

tgggtcaact cagaagataa gaattggcaa gagttatata aaaaatataa gcccgacttt     780

aatagcgatg caaccagtac atcaagattc cttagtagag atgaattaaa attcgcatta     840

cgctcttggg aaatgaatgg atccttcatt cgaaaaattt ttattgtctc taattgtgct     900

cccccagcat ggctagattt aaataaccct aaaattcaat gggtatatca cgaagaaatt     960

atgccacaaa gtgcccttcc tacttttagc tcacatgcta ttgaaaccag cttgcaccat    1020

ataccaggaa ttagtaacta ttttatttac agcaatgacg acttcctatt aactaaacca    1080

ttgaataaag acaatttctt ctattcgaat ggtattgcaa agttaagatt agaagcatgg    1140

ggaaatgtta atggtgaatg tactgaagga gaacctgact acttaaatgg tgctcgcaat    1200

gcgaacactc tcttagaaaa ggaatttaaa aaatttacta ctaaactaca tactcactcc    1260

cctcaatcca tgagaactga tattttattt gagatggaaa aaaaatatcc agaagagttt    1320

aatagaacac tacataataa attccgatct ttagatgata ttgcagtaac gggctatctc    1380

tatcatcatt atgccctact ctctggacga gcactacaaa gttctgacaa gacggaactt    1440

gtacagcaaa atcatgattt caaaaagaaa ctaaataatg tagtgacctt aactaaagaa    1500

aggaattttg acaaacttcc tttgagcgta tgtatcaacg atggtgctga tagtcac       1557


<210> 9
<211> 545
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS CP-A/CsaB wildtyp/full-length (544 without M1)

<400> 9
Met Phe Ile Leu Asn Asn Arg Lys Trp Arg Lys Leu Lys Arg Asp Pro 
1               5                   10                  15      
Ser Ala Phe Phe Arg Asp Ser Lys Phe Asn Phe Leu Arg Tyr Phe Ser 
            20                  25                  30          
Ala Lys Lys Phe Ala Lys Asn Phe Lys Asn Ser Ser His Ile His Lys 
        35                  40                  45              
Thr Asn Ile Ser Lys Ala Gln Ser Asn Ile Ser Ser Thr Leu Lys Gln 
    50                  55                  60                  
Asn Arg Lys Gln Asp Met Leu Ile Pro Ile Asn Phe Phe Asn Phe Glu 
65                  70                  75                  80  
Tyr Ile Val Lys Lys Leu Asn Asn Gln Asn Ala Ile Gly Val Tyr Ile 
                85                  90                  95      
Leu Pro Ser Asn Leu Thr Leu Lys Pro Ala Leu Cys Ile Leu Glu Ser 
            100                 105                 110         
His Lys Glu Asp Phe Leu Asn Lys Phe Leu Leu Thr Ile Ser Ser Glu 
        115                 120                 125             
Asn Leu Lys Leu Gln Tyr Lys Phe Asn Gly Gln Ile Lys Asn Pro Lys 
    130                 135                 140                 
Ser Val Asn Glu Ile Trp Thr Asp Leu Phe Ser Ile Ala His Val Asp 
145                 150                 155                 160 
Met Lys Leu Ser Thr Asp Arg Thr Leu Ser Ser Ser Ile Ser Gln Phe 
                165                 170                 175     
Trp Phe Arg Leu Glu Phe Cys Lys Glu Asp Lys Asp Phe Ile Leu Phe 
            180                 185                 190         
Pro Thr Ala Asn Arg Tyr Ser Arg Lys Leu Trp Lys His Ser Ile Lys 
        195                 200                 205             
Asn Asn Gln Leu Phe Lys Glu Gly Ile Arg Asn Tyr Ser Glu Ile Ser 
    210                 215                 220                 
Ser Leu Pro Tyr Glu Glu Asp His Asn Phe Asp Ile Asp Leu Val Phe 
225                 230                 235                 240 
Thr Trp Val Asn Ser Glu Asp Lys Asn Trp Gln Glu Leu Tyr Lys Lys 
                245                 250                 255     
Tyr Lys Pro Asp Phe Asn Ser Asp Ala Thr Ser Thr Ser Arg Phe Leu 
            260                 265                 270         
Ser Arg Asp Glu Leu Lys Phe Ala Leu Arg Ser Trp Glu Met Asn Gly 
        275                 280                 285             
Ser Phe Ile Arg Lys Ile Phe Ile Val Ser Asn Cys Ala Pro Pro Ala 
    290                 295                 300                 
Trp Leu Asp Leu Asn Asn Pro Lys Ile Gln Trp Val Tyr His Glu Glu 
305                 310                 315                 320 
Ile Met Pro Gln Ser Ala Leu Pro Thr Phe Ser Ser His Ala Ile Glu 
                325                 330                 335     
Thr Ser Leu His His Ile Pro Gly Ile Ser Asn Tyr Phe Ile Tyr Ser 
            340                 345                 350         
Asn Asp Asp Phe Leu Leu Thr Lys Pro Leu Asn Lys Asp Asn Phe Phe 
        355                 360                 365             
Tyr Ser Asn Gly Ile Ala Lys Leu Arg Leu Glu Ala Trp Gly Asn Val 
    370                 375                 380                 
Asn Gly Glu Cys Thr Glu Gly Glu Pro Asp Tyr Leu Asn Gly Ala Arg 
385                 390                 395                 400 
Asn Ala Asn Thr Leu Leu Glu Lys Glu Phe Lys Lys Phe Thr Thr Lys 
                405                 410                 415     
Leu His Thr His Ser Pro Gln Ser Met Arg Thr Asp Ile Leu Phe Glu 
            420                 425                 430         
Met Glu Lys Lys Tyr Pro Glu Glu Phe Asn Arg Thr Leu His Asn Lys 
        435                 440                 445             
Phe Arg Ser Leu Asp Asp Ile Ala Val Thr Gly Tyr Leu Tyr His His 
    450                 455                 460                 
Tyr Ala Leu Leu Ser Gly Arg Ala Leu Gln Ser Ser Asp Lys Thr Glu 
465                 470                 475                 480 
Leu Val Gln Gln Asn His Asp Phe Lys Lys Lys Leu Asn Asn Val Val 
                485                 490                 495     
Thr Leu Thr Lys Glu Arg Asn Phe Asp Lys Leu Pro Leu Ser Val Cys 
            500                 505                 510         
Ile Asn Asp Gly Ala Asp Ser His Leu Asn Glu Glu Trp Asn Val Gln 
        515                 520                 525             
Val Ile Lys Phe Leu Glu Thr Leu Phe Pro Leu Pro Ser Ser Phe Glu 
    530                 535                 540                 
Lys 
545 

<210> 10
<211> 475
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS deltaN69-CP-A (codon optimized) (475)

<400> 10
Leu Ile Pro Ile Asn Phe Phe Asn Phe Glu Tyr Ile Val Lys Lys Leu 
1               5                   10                  15      
Asn Asn Gln Asn Ala Ile Gly Val Tyr Ile Leu Pro Ser Asn Leu Thr 
            20                  25                  30          
Leu Lys Pro Ala Leu Cys Ile Leu Glu Ser His Lys Glu Asp Phe Leu 
        35                  40                  45              
Asn Lys Phe Leu Leu Thr Ile Ser Ser Glu Asn Leu Lys Leu Gln Tyr 
    50                  55                  60                  
Lys Phe Asn Gly Gln Ile Lys Asn Pro Lys Ser Val Asn Glu Ile Trp 
65                  70                  75                  80  
Thr Asp Leu Phe Ser Ile Ala His Val Asp Met Lys Leu Ser Thr Asp 
                85                  90                  95      
Arg Thr Leu Ser Ser Ser Ile Ser Gln Phe Trp Phe Arg Leu Glu Phe 
            100                 105                 110         
Cys Lys Glu Asp Lys Asp Phe Ile Leu Phe Pro Thr Ala Asn Arg Tyr 
        115                 120                 125             
Ser Arg Lys Leu Trp Lys His Ser Ile Lys Asn Asn Gln Leu Phe Lys 
    130                 135                 140                 
Glu Gly Ile Arg Asn Tyr Ser Glu Ile Ser Ser Leu Pro Tyr Glu Glu 
145                 150                 155                 160 
Asp His Asn Phe Asp Ile Asp Leu Val Phe Thr Trp Val Asn Ser Glu 
                165                 170                 175     
Asp Lys Asn Trp Gln Glu Leu Tyr Lys Lys Tyr Lys Pro Asp Phe Asn 
            180                 185                 190         
Ser Asp Ala Thr Ser Thr Ser Arg Phe Leu Ser Arg Asp Glu Leu Lys 
        195                 200                 205             
Phe Ala Leu Arg Ser Trp Glu Met Asn Gly Ser Phe Ile Arg Lys Ile 
    210                 215                 220                 
Phe Ile Val Ser Asn Cys Ala Pro Pro Ala Trp Leu Asp Leu Asn Asn 
225                 230                 235                 240 
Pro Lys Ile Gln Trp Val Tyr His Glu Glu Ile Met Pro Gln Ser Ala 
                245                 250                 255     
Leu Pro Thr Phe Ser Ser His Ala Ile Glu Thr Ser Leu His His Ile 
            260                 265                 270         
Pro Gly Ile Ser Asn Tyr Phe Ile Tyr Ser Asn Asp Asp Phe Leu Leu 
        275                 280                 285             
Thr Lys Pro Leu Asn Lys Asp Asn Phe Phe Tyr Ser Asn Gly Ile Ala 
    290                 295                 300                 
Lys Leu Arg Leu Glu Ala Trp Gly Asn Val Asn Gly Glu Cys Thr Glu 
305                 310                 315                 320 
Gly Glu Pro Asp Tyr Leu Asn Gly Ala Arg Asn Ala Asn Thr Leu Leu 
                325                 330                 335     
Glu Lys Glu Phe Lys Lys Phe Thr Thr Lys Leu His Thr His Ser Pro 
            340                 345                 350         
Gln Ser Met Arg Thr Asp Ile Leu Phe Glu Met Glu Lys Lys Tyr Pro 
        355                 360                 365             
Glu Glu Phe Asn Arg Thr Leu His Asn Lys Phe Arg Ser Leu Asp Asp 
    370                 375                 380                 
Ile Ala Val Thr Gly Tyr Leu Tyr His His Tyr Ala Leu Leu Ser Gly 
385                 390                 395                 400 
Arg Ala Leu Gln Ser Ser Asp Lys Thr Glu Leu Val Gln Gln Asn His 
                405                 410                 415     
Asp Phe Lys Lys Lys Leu Asn Asn Val Val Thr Leu Thr Lys Glu Arg 
            420                 425                 430         
Asn Phe Asp Lys Leu Pro Leu Ser Val Cys Ile Asn Asp Gly Ala Asp 
        435                 440                 445             
Ser His Leu Asn Glu Glu Trp Asn Val Gln Val Ile Lys Phe Leu Glu 
    450                 455                 460                 
Thr Leu Phe Pro Leu Pro Ser Ser Phe Glu Lys 
465                 470                 475 

<210> 11
<211> 448
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS deltaN97-CP-A (448)

<400> 11
Pro Ser Asn Leu Thr Leu Lys Pro Ala Leu Cys Ile Leu Glu Ser His 
1               5                   10                  15      
Lys Glu Asp Phe Leu Asn Lys Phe Leu Leu Thr Ile Ser Ser Glu Asn 
            20                  25                  30          
Leu Lys Leu Gln Tyr Lys Phe Asn Gly Gln Ile Lys Asn Pro Lys Ser 
        35                  40                  45              
Val Asn Glu Ile Trp Thr Asp Leu Phe Ser Ile Ala His Val Asp Met 
    50                  55                  60                  
Lys Leu Ser Thr Asp Arg Thr Leu Ser Ser Ser Ile Ser Gln Phe Trp 
65                  70                  75                  80  
Phe Arg Leu Glu Phe Cys Lys Glu Asp Lys Asp Phe Ile Leu Phe Pro 
                85                  90                  95      
Thr Ala Asn Arg Tyr Ser Arg Lys Leu Trp Lys His Ser Ile Lys Asn 
            100                 105                 110         
Asn Gln Leu Phe Lys Glu Gly Ile Arg Asn Tyr Ser Glu Ile Ser Ser 
        115                 120                 125             
Leu Pro Tyr Glu Glu Asp His Asn Phe Asp Ile Asp Leu Val Phe Thr 
    130                 135                 140                 
Trp Val Asn Ser Glu Asp Lys Asn Trp Gln Glu Leu Tyr Lys Lys Tyr 
145                 150                 155                 160 
Lys Pro Asp Phe Asn Ser Asp Ala Thr Ser Thr Ser Arg Phe Leu Ser 
                165                 170                 175     
Arg Asp Glu Leu Lys Phe Ala Leu Arg Ser Trp Glu Met Asn Gly Ser 
            180                 185                 190         
Phe Ile Arg Lys Ile Phe Ile Val Ser Asn Cys Ala Pro Pro Ala Trp 
        195                 200                 205             
Leu Asp Leu Asn Asn Pro Lys Ile Gln Trp Val Tyr His Glu Glu Ile 
    210                 215                 220                 
Met Pro Gln Ser Ala Leu Pro Thr Phe Ser Ser His Ala Ile Glu Thr 
225                 230                 235                 240 
Ser Leu His His Ile Pro Gly Ile Ser Asn Tyr Phe Ile Tyr Ser Asn 
                245                 250                 255     
Asp Asp Phe Leu Leu Thr Lys Pro Leu Asn Lys Asp Asn Phe Phe Tyr 
            260                 265                 270         
Ser Asn Gly Ile Ala Lys Leu Arg Leu Glu Ala Trp Gly Asn Val Asn 
        275                 280                 285             
Gly Glu Cys Thr Glu Gly Glu Pro Asp Tyr Leu Asn Gly Ala Arg Asn 
    290                 295                 300                 
Ala Asn Thr Leu Leu Glu Lys Glu Phe Lys Lys Phe Thr Thr Lys Leu 
305                 310                 315                 320 
His Thr His Ser Pro Gln Ser Met Arg Thr Asp Ile Leu Phe Glu Met 
                325                 330                 335     
Glu Lys Lys Tyr Pro Glu Glu Phe Asn Arg Thr Leu His Asn Lys Phe 
            340                 345                 350         
Arg Ser Leu Asp Asp Ile Ala Val Thr Gly Tyr Leu Tyr His His Tyr 
        355                 360                 365             
Ala Leu Leu Ser Gly Arg Ala Leu Gln Ser Ser Asp Lys Thr Glu Leu 
    370                 375                 380                 
Val Gln Gln Asn His Asp Phe Lys Lys Lys Leu Asn Asn Val Val Thr 
385                 390                 395                 400 
Leu Thr Lys Glu Arg Asn Phe Asp Lys Leu Pro Leu Ser Val Cys Ile 
                405                 410                 415     
Asn Asp Gly Ala Asp Ser His Leu Asn Glu Glu Trp Asn Val Gln Val 
            420                 425                 430         
Ile Lys Phe Leu Glu Thr Leu Phe Pro Leu Pro Ser Ser Phe Glu Lys 
        435                 440                 445             



<210> 12
<211> 378
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS deltaN167-CP-A (378)

<400> 12
Thr Leu Ser Ser Ser Ile Ser Gln Phe Trp Phe Arg Leu Glu Phe Cys 
1               5                   10                  15      
Lys Glu Asp Lys Asp Phe Ile Leu Phe Pro Thr Ala Asn Arg Tyr Ser 
            20                  25                  30          
Arg Lys Leu Trp Lys His Ser Ile Lys Asn Asn Gln Leu Phe Lys Glu 
        35                  40                  45              
Gly Ile Arg Asn Tyr Ser Glu Ile Ser Ser Leu Pro Tyr Glu Glu Asp 
    50                  55                  60                  
His Asn Phe Asp Ile Asp Leu Val Phe Thr Trp Val Asn Ser Glu Asp 
65                  70                  75                  80  
Lys Asn Trp Gln Glu Leu Tyr Lys Lys Tyr Lys Pro Asp Phe Asn Ser 
                85                  90                  95      
Asp Ala Thr Ser Thr Ser Arg Phe Leu Ser Arg Asp Glu Leu Lys Phe 
            100                 105                 110         
Ala Leu Arg Ser Trp Glu Met Asn Gly Ser Phe Ile Arg Lys Ile Phe 
        115                 120                 125             
Ile Val Ser Asn Cys Ala Pro Pro Ala Trp Leu Asp Leu Asn Asn Pro 
    130                 135                 140                 
Lys Ile Gln Trp Val Tyr His Glu Glu Ile Met Pro Gln Ser Ala Leu 
145                 150                 155                 160 
Pro Thr Phe Ser Ser His Ala Ile Glu Thr Ser Leu His His Ile Pro 
                165                 170                 175     
Gly Ile Ser Asn Tyr Phe Ile Tyr Ser Asn Asp Asp Phe Leu Leu Thr 
            180                 185                 190         
Lys Pro Leu Asn Lys Asp Asn Phe Phe Tyr Ser Asn Gly Ile Ala Lys 
        195                 200                 205             
Leu Arg Leu Glu Ala Trp Gly Asn Val Asn Gly Glu Cys Thr Glu Gly 
    210                 215                 220                 
Glu Pro Asp Tyr Leu Asn Gly Ala Arg Asn Ala Asn Thr Leu Leu Glu 
225                 230                 235                 240 
Lys Glu Phe Lys Lys Phe Thr Thr Lys Leu His Thr His Ser Pro Gln 
                245                 250                 255     
Ser Met Arg Thr Asp Ile Leu Phe Glu Met Glu Lys Lys Tyr Pro Glu 
            260                 265                 270         
Glu Phe Asn Arg Thr Leu His Asn Lys Phe Arg Ser Leu Asp Asp Ile 
        275                 280                 285             
Ala Val Thr Gly Tyr Leu Tyr His His Tyr Ala Leu Leu Ser Gly Arg 
    290                 295                 300                 
Ala Leu Gln Ser Ser Asp Lys Thr Glu Leu Val Gln Gln Asn His Asp 
305                 310                 315                 320 
Phe Lys Lys Lys Leu Asn Asn Val Val Thr Leu Thr Lys Glu Arg Asn 
                325                 330                 335     
Phe Asp Lys Leu Pro Leu Ser Val Cys Ile Asn Asp Gly Ala Asp Ser 
            340                 345                 350         
His Leu Asn Glu Glu Trp Asn Val Gln Val Ile Lys Phe Leu Glu Thr 
        355                 360                 365             
Leu Phe Pro Leu Pro Ser Ser Phe Glu Lys 
    370                 375             

<210> 13
<211> 311
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS deltaN235-CP-A (311)

<400> 13
Asp Ile Asp Leu Val Phe Thr Trp Val Asn Ser Glu Asp Lys Asn Trp 
1               5                   10                  15      
Gln Glu Leu Tyr Lys Lys Tyr Lys Pro Asp Phe Asn Ser Asp Ala Thr 
            20                  25                  30          
Ser Thr Ser Arg Phe Leu Ser Arg Asp Glu Leu Lys Phe Ala Leu Arg 
        35                  40                  45              
Ser Trp Glu Met Asn Gly Ser Phe Ile Arg Lys Ile Phe Ile Val Ser 
    50                  55                  60                  
Asn Cys Ala Pro Pro Ala Trp Leu Asp Leu Asn Asn Pro Lys Ile Gln 
65                  70                  75                  80  
Trp Val Tyr His Glu Glu Ile Met Pro Gln Ser Ala Leu Pro Thr Phe 
                85                  90                  95      
Ser Ser His Ala Ile Glu Thr Ser Leu His His Ile Pro Gly Ile Ser 
            100                 105                 110         
Asn Tyr Phe Ile Tyr Ser Asn Asp Asp Phe Leu Leu Thr Lys Pro Leu 
        115                 120                 125             
Asn Lys Asp Asn Phe Phe Tyr Ser Asn Gly Ile Ala Lys Leu Arg Leu 
    130                 135                 140                 
Glu Ala Trp Gly Asn Val Asn Gly Glu Cys Thr Glu Gly Glu Pro Asp 
145                 150                 155                 160 
Tyr Leu Asn Gly Ala Arg Asn Ala Asn Thr Leu Leu Glu Lys Glu Phe 
                165                 170                 175     
Lys Lys Phe Thr Thr Lys Leu His Thr His Ser Pro Gln Ser Met Arg 
            180                 185                 190         
Thr Asp Ile Leu Phe Glu Met Glu Lys Lys Tyr Pro Glu Glu Phe Asn 
        195                 200                 205             
Arg Thr Leu His Asn Lys Phe Arg Ser Leu Asp Asp Ile Ala Val Thr 
    210                 215                 220                 
Gly Tyr Leu Tyr His His Tyr Ala Leu Leu Ser Gly Arg Ala Leu Gln 
225                 230                 235                 240 
Ser Ser Asp Lys Thr Glu Leu Val Gln Gln Asn His Asp Phe Lys Lys 
                245                 250                 255     
Lys Leu Asn Asn Val Val Thr Leu Thr Lys Glu Arg Asn Phe Asp Lys 
            260                 265                 270         
Leu Pro Leu Ser Val Cys Ile Asn Asp Gly Ala Asp Ser His Leu Asn 
        275                 280                 285             
Glu Glu Trp Asn Val Gln Val Ile Lys Phe Leu Glu Thr Leu Phe Pro 
    290                 295                 300                 
Leu Pro Ser Ser Phe Glu Lys 
305                 310     

<210> 14
<211> 499
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS deltaC45-CP-A (499)

<400> 14
Phe Ile Leu Asn Asn Arg Lys Trp Arg Lys Leu Lys Arg Asp Pro Ser 
1               5                   10                  15      
Ala Phe Phe Arg Asp Ser Lys Phe Asn Phe Leu Arg Tyr Phe Ser Ala 
            20                  25                  30          
Lys Lys Phe Ala Lys Asn Phe Lys Asn Ser Ser His Ile His Lys Thr 
        35                  40                  45              
Asn Ile Ser Lys Ala Gln Ser Asn Ile Ser Ser Thr Leu Lys Gln Asn 
    50                  55                  60                  
Arg Lys Gln Asp Met Leu Ile Pro Ile Asn Phe Phe Asn Phe Glu Tyr 
65                  70                  75                  80  
Ile Val Lys Lys Leu Asn Asn Gln Asn Ala Ile Gly Val Tyr Ile Leu 
                85                  90                  95      
Pro Ser Asn Leu Thr Leu Lys Pro Ala Leu Cys Ile Leu Glu Ser His 
            100                 105                 110         
Lys Glu Asp Phe Leu Asn Lys Phe Leu Leu Thr Ile Ser Ser Glu Asn 
        115                 120                 125             
Leu Lys Leu Gln Tyr Lys Phe Asn Gly Gln Ile Lys Asn Pro Lys Ser 
    130                 135                 140                 
Val Asn Glu Ile Trp Thr Asp Leu Phe Ser Ile Ala His Val Asp Met 
145                 150                 155                 160 
Lys Leu Ser Thr Asp Arg Thr Leu Ser Ser Ser Ile Ser Gln Phe Trp 
                165                 170                 175     
Phe Arg Leu Glu Phe Cys Lys Glu Asp Lys Asp Phe Ile Leu Phe Pro 
            180                 185                 190         
Thr Ala Asn Arg Tyr Ser Arg Lys Leu Trp Lys His Ser Ile Lys Asn 
        195                 200                 205             
Asn Gln Leu Phe Lys Glu Gly Ile Arg Asn Tyr Ser Glu Ile Ser Ser 
    210                 215                 220                 
Leu Pro Tyr Glu Glu Asp His Asn Phe Asp Ile Asp Leu Val Phe Thr 
225                 230                 235                 240 
Trp Val Asn Ser Glu Asp Lys Asn Trp Gln Glu Leu Tyr Lys Lys Tyr 
                245                 250                 255     
Lys Pro Asp Phe Asn Ser Asp Ala Thr Ser Thr Ser Arg Phe Leu Ser 
            260                 265                 270         
Arg Asp Glu Leu Lys Phe Ala Leu Arg Ser Trp Glu Met Asn Gly Ser 
        275                 280                 285             
Phe Ile Arg Lys Ile Phe Ile Val Ser Asn Cys Ala Pro Pro Ala Trp 
    290                 295                 300                 
Leu Asp Leu Asn Asn Pro Lys Ile Gln Trp Val Tyr His Glu Glu Ile 
305                 310                 315                 320 
Met Pro Gln Ser Ala Leu Pro Thr Phe Ser Ser His Ala Ile Glu Thr 
                325                 330                 335     
Ser Leu His His Ile Pro Gly Ile Ser Asn Tyr Phe Ile Tyr Ser Asn 
            340                 345                 350         
Asp Asp Phe Leu Leu Thr Lys Pro Leu Asn Lys Asp Asn Phe Phe Tyr 
        355                 360                 365             
Ser Asn Gly Ile Ala Lys Leu Arg Leu Glu Ala Trp Gly Asn Val Asn 
    370                 375                 380                 
Gly Glu Cys Thr Glu Gly Glu Pro Asp Tyr Leu Asn Gly Ala Arg Asn 
385                 390                 395                 400 
Ala Asn Thr Leu Leu Glu Lys Glu Phe Lys Lys Phe Thr Thr Lys Leu 
                405                 410                 415     
His Thr His Ser Pro Gln Ser Met Arg Thr Asp Ile Leu Phe Glu Met 
            420                 425                 430         
Glu Lys Lys Tyr Pro Glu Glu Phe Asn Arg Thr Leu His Asn Lys Phe 
        435                 440                 445             
Arg Ser Leu Asp Asp Ile Ala Val Thr Gly Tyr Leu Tyr His His Tyr 
    450                 455                 460                 
Ala Leu Leu Ser Gly Arg Ala Leu Gln Ser Ser Asp Lys Thr Glu Leu 
465                 470                 475                 480 
Val Gln Gln Asn His Asp Phe Lys Lys Lys Leu Asn Asn Val Val Thr 
                485                 490                 495     
Leu Thr Lys 
            

<210> 15
<211> 519
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS deltaC25-CP-A (519)

<400> 15
Phe Ile Leu Asn Asn Arg Lys Trp Arg Lys Leu Lys Arg Asp Pro Ser 
1               5                   10                  15      
Ala Phe Phe Arg Asp Ser Lys Phe Asn Phe Leu Arg Tyr Phe Ser Ala 
            20                  25                  30          
Lys Lys Phe Ala Lys Asn Phe Lys Asn Ser Ser His Ile His Lys Thr 
        35                  40                  45              
Asn Ile Ser Lys Ala Gln Ser Asn Ile Ser Ser Thr Leu Lys Gln Asn 
    50                  55                  60                  
Arg Lys Gln Asp Met Leu Ile Pro Ile Asn Phe Phe Asn Phe Glu Tyr 
65                  70                  75                  80  
Ile Val Lys Lys Leu Asn Asn Gln Asn Ala Ile Gly Val Tyr Ile Leu 
                85                  90                  95      
Pro Ser Asn Leu Thr Leu Lys Pro Ala Leu Cys Ile Leu Glu Ser His 
            100                 105                 110         
Lys Glu Asp Phe Leu Asn Lys Phe Leu Leu Thr Ile Ser Ser Glu Asn 
        115                 120                 125             
Leu Lys Leu Gln Tyr Lys Phe Asn Gly Gln Ile Lys Asn Pro Lys Ser 
    130                 135                 140                 
Val Asn Glu Ile Trp Thr Asp Leu Phe Ser Ile Ala His Val Asp Met 
145                 150                 155                 160 
Lys Leu Ser Thr Asp Arg Thr Leu Ser Ser Ser Ile Ser Gln Phe Trp 
                165                 170                 175     
Phe Arg Leu Glu Phe Cys Lys Glu Asp Lys Asp Phe Ile Leu Phe Pro 
            180                 185                 190         
Thr Ala Asn Arg Tyr Ser Arg Lys Leu Trp Lys His Ser Ile Lys Asn 
        195                 200                 205             
Asn Gln Leu Phe Lys Glu Gly Ile Arg Asn Tyr Ser Glu Ile Ser Ser 
    210                 215                 220                 
Leu Pro Tyr Glu Glu Asp His Asn Phe Asp Ile Asp Leu Val Phe Thr 
225                 230                 235                 240 
Trp Val Asn Ser Glu Asp Lys Asn Trp Gln Glu Leu Tyr Lys Lys Tyr 
                245                 250                 255     
Lys Pro Asp Phe Asn Ser Asp Ala Thr Ser Thr Ser Arg Phe Leu Ser 
            260                 265                 270         
Arg Asp Glu Leu Lys Phe Ala Leu Arg Ser Trp Glu Met Asn Gly Ser 
        275                 280                 285             
Phe Ile Arg Lys Ile Phe Ile Val Ser Asn Cys Ala Pro Pro Ala Trp 
    290                 295                 300                 
Leu Asp Leu Asn Asn Pro Lys Ile Gln Trp Val Tyr His Glu Glu Ile 
305                 310                 315                 320 
Met Pro Gln Ser Ala Leu Pro Thr Phe Ser Ser His Ala Ile Glu Thr 
                325                 330                 335     
Ser Leu His His Ile Pro Gly Ile Ser Asn Tyr Phe Ile Tyr Ser Asn 
            340                 345                 350         
Asp Asp Phe Leu Leu Thr Lys Pro Leu Asn Lys Asp Asn Phe Phe Tyr 
        355                 360                 365             
Ser Asn Gly Ile Ala Lys Leu Arg Leu Glu Ala Trp Gly Asn Val Asn 
    370                 375                 380                 
Gly Glu Cys Thr Glu Gly Glu Pro Asp Tyr Leu Asn Gly Ala Arg Asn 
385                 390                 395                 400 
Ala Asn Thr Leu Leu Glu Lys Glu Phe Lys Lys Phe Thr Thr Lys Leu 
                405                 410                 415     
His Thr His Ser Pro Gln Ser Met Arg Thr Asp Ile Leu Phe Glu Met 
            420                 425                 430         
Glu Lys Lys Tyr Pro Glu Glu Phe Asn Arg Thr Leu His Asn Lys Phe 
        435                 440                 445             
Arg Ser Leu Asp Asp Ile Ala Val Thr Gly Tyr Leu Tyr His His Tyr 
    450                 455                 460                 
Ala Leu Leu Ser Gly Arg Ala Leu Gln Ser Ser Asp Lys Thr Glu Leu 
465                 470                 475                 480 
Val Gln Gln Asn His Asp Phe Lys Lys Lys Leu Asn Asn Val Val Thr 
                485                 490                 495     
Leu Thr Lys Glu Arg Asn Phe Asp Lys Leu Pro Leu Ser Val Cys Ile 
            500                 505                 510         
Asn Asp Gly Ala Asp Ser His 
        515                 

<210> 16
<211> 1455
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA CP-X/CsxA full-length (1455)

<400> 16
attatgagca aaattagcaa attggtaacc cacccaaacc ttttctttcg agattatttc      60

ttaaaaaaag caccgttaaa ttatggcgaa aatattaaac ctttaccagt cgaaacctct     120

tctcatagca aaaaaaatac agcccataaa acacccgtat catccgacca accaattgaa     180

gatccatacc cagtaacatt tccaattgat gtagtttata cttgggtaga ttcagatgat     240

gaaaaattca atgaagaacg cctaaagttt caaaattcaa gcacatctga gactctacaa     300

ggcaaagcag aaagcaccga tattgcaaga ttccaatcac gcgacgaatt aaaatattcg     360

attcgaagcc tgatgaagta tgccccatgg gtaaatcata tttacattgt aacaaatggt     420

caaataccaa aatggttaga taccaacaat acaaaggtaa cgattatccc tcactcaact     480

attatcgaca gtcaatttct ccctactttt aattctcacg tcattgaatc ctctctatat     540

aaaatcccag gattatcaga gcattacatt tatttcaatg atgatgtcat gctagctaga     600

gatttaagcc catcttattt ctttacaagc agcggattag caaaactgtt tattaccaac     660

tctcgtctac caaatggcta taagaatgtg aaagacacac caacccaatg ggcctcaaaa     720

aattcccgtg agcttttaca tgcagaaaca ggattttggg ctgaagccat gtttgcacat     780

acttttcatc cacaacgtaa aagtgtacat gaatctattg aacacctatg gcatgaacaa     840

ttaaatgttt gtcgtcaaaa ccgtttccgt gatatttcag atattaacat ggcgacattc     900

ctgcaccacc attttgccat tttgacaggc caagctcttg ctacacgcac taaatgtatt     960

tactttaaca ttcgctctcc tcaagcagct cagcattaca aaacattatt agctcgaaaa    1020

ggaagcgaat acagcccaca ttctatctgc ttaaatgatc atacatcgag caataaaaat    1080

attttatcta attacgaagc caaattacaa agctttttag aaacatacta tccagatgta    1140

tcagaagcag aaattctcct tcctactaaa tctgaagtag ctgaattagt taaacataaa    1200

gattatttaa ctgtatatac taaattatta cctattatca ataagcagct ggtcaataaa    1260

tataataaac cttattcata tcttttctat tatttaggtt tatctgcccg gtttttattt    1320

gaagaaacgc aacaagaaca ctaccgggaa actgctgaag aaaatttaca aatcttttgt    1380

ggcctaaacc caaaacatac actagccctc aaatacttag cggatgtcac cctcacatca    1440

cagcctagtg gacaa                                                     1455


<210> 17
<211> 1284
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA deltaN58-CP-X (1284)

<400> 17
ccaattgaag atccataccc agtaacattt ccaattgatg tagtttatac ttgggtagat      60

tcagatgatg aaaaattcaa tgaagaacgc ctaaagtttc aaaattcaag cacatctgag     120

actctacaag gcaaagcaga aagcaccgat attgcaagat tccaatcacg cgacgaatta     180

aaatattcga ttcgaagcct gatgaagtat gccccatggg taaatcatat ttacattgta     240

acaaatggtc aaataccaaa atggttagat accaacaata caaaggtaac gattatccct     300

cactcaacta ttatcgacag tcaatttctc cctactttta attctcacgt cattgaatcc     360

tctctatata aaatcccagg attatcagag cattacattt atttcaatga tgatgtcatg     420

ctagctagag atttaagccc atcttatttc tttacaagca gcggattagc aaaactgttt     480

attaccaact ctcgtctacc aaatggctat aagaatgtga aagacacacc aacccaatgg     540

gcctcaaaaa attcccgtga gcttttacat gcagaaacag gattttgggc tgaagccatg     600

tttgcacata cttttcatcc acaacgtaaa agtgtacatg aatctattga acacctatgg     660

catgaacaat taaatgtttg tcgtcaaaac cgtttccgtg atatttcaga tattaacatg     720

gcgacattcc tgcaccacca ttttgccatt ttgacaggcc aagctcttgc tacacgcact     780

aaatgtattt actttaacat tcgctctcct caagcagctc agcattacaa aacattatta     840

gctcgaaaag gaagcgaata cagcccacat tctatctgct taaatgatca tacatcgagc     900

aataaaaata ttttatctaa ttacgaagcc aaattacaaa gctttttaga aacatactat     960

ccagatgtat cagaagcaga aattctcctt cctactaaat ctgaagtagc tgaattagtt    1020

aaacataaag attatttaac tgtatatact aaattattac ctattatcaa taagcagctg    1080

gtcaataaat ataataaacc ttattcatat cttttctatt atttaggttt atctgcccgg    1140

tttttatttg aagaaacgca acaagaacac taccgggaaa ctgctgaaga aaatttacaa    1200

atcttttgtg gcctaaaccc aaaacataca ctagccctca aatacttagc ggatgtcacc    1260

ctcacatcac agcctagtgg acaa                                           1284


<210> 18
<211> 1146
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA deltaN104-CP-X (1146)

<400> 18
gaaagcaccg atattgcaag attccaatca cgcgacgaat taaaatattc gattcgaagc      60

ctgatgaagt atgccccatg ggtaaatcat atttacattg taacaaatgg tcaaatacca     120

aaatggttag ataccaacaa tacaaaggta acgattatcc ctcactcaac tattatcgac     180

agtcaatttc tccctacttt taattctcac gtcattgaat cctctctata taaaatccca     240

ggattatcag agcattacat ttatttcaat gatgatgtca tgctagctag agatttaagc     300

ccatcttatt tctttacaag cagcggatta gcaaaactgt ttattaccaa ctctcgtcta     360

ccaaatggct ataagaatgt gaaagacaca ccaacccaat gggcctcaaa aaattcccgt     420

gagcttttac atgcagaaac aggattttgg gctgaagcca tgtttgcaca tacttttcat     480

ccacaacgta aaagtgtaca tgaatctatt gaacacctat ggcatgaaca attaaatgtt     540

tgtcgtcaaa accgtttccg tgatatttca gatattaaca tggcgacatt cctgcaccac     600

cattttgcca ttttgacagg ccaagctctt gctacacgca ctaaatgtat ttactttaac     660

attcgctctc ctcaagcagc tcagcattac aaaacattat tagctcgaaa aggaagcgaa     720

tacagcccac attctatctg cttaaatgat catacatcga gcaataaaaa tattttatct     780

aattacgaag ccaaattaca aagcttttta gaaacatact atccagatgt atcagaagca     840

gaaattctcc ttcctactaa atctgaagta gctgaattag ttaaacataa agattattta     900

actgtatata ctaaattatt acctattatc aataagcagc tggtcaataa atataataaa     960

ccttattcat atcttttcta ttatttaggt ttatctgccc ggtttttatt tgaagaaacg    1020

caacaagaac actaccggga aactgctgaa gaaaatttac aaatcttttg tggcctaaac    1080

ccaaaacata cactagccct caaatactta gcggatgtca ccctcacatc acagcctagt    1140

ggacaa                                                               1146


<210> 19
<211> 933
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA deltaC174-CP-X (933)

<400> 19
attatgagca aaattagcaa attggtaacc cacccaaacc ttttctttcg agattatttc      60

ttaaaaaaag caccgttaaa ttatggcgaa aatattaaac ctttaccagt cgaaacctct     120

tctcatagca aaaaaaatac agcccataaa acacccgtat catccgacca accaattgaa     180

gatccatacc cagtaacatt tccaattgat gtagtttata cttgggtaga ttcagatgat     240

gaaaaattca atgaagaacg cctaaagttt caaaattcaa gcacatctga gactctacaa     300

ggcaaagcag aaagcaccga tattgcaaga ttccaatcac gcgacgaatt aaaatattcg     360

attcgaagcc tgatgaagta tgccccatgg gtaaatcata tttacattgt aacaaatggt     420

caaataccaa aatggttaga taccaacaat acaaaggtaa cgattatccc tcactcaact     480

attatcgaca gtcaatttct ccctactttt aattctcacg tcattgaatc ctctctatat     540

aaaatcccag gattatcaga gcattacatt tatttcaatg atgatgtcat gctagctaga     600

gatttaagcc catcttattt ctttacaagc agcggattag caaaactgtt tattaccaac     660

tctcgtctac caaatggcta taagaatgtg aaagacacac caacccaatg ggcctcaaaa     720

aattcccgtg agcttttaca tgcagaaaca ggattttggg ctgaagccat gtttgcacat     780

acttttcatc cacaacgtaa aagtgtacat gaatctattg aacacctatg gcatgaacaa     840

ttaaatgttt gtcgtcaaaa ccgtttccgt gatatttcag atattaacat ggcgacattc     900

ctgcaccacc attttgccat tttgacaggc caa                                  933


<210> 20
<211> 1158
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA deltaC99-CP-X (1158)

<400> 20
attatgagca aaattagcaa attggtaacc cacccaaacc ttttctttcg agattatttc      60

ttaaaaaaag caccgttaaa ttatggcgaa aatattaaac ctttaccagt cgaaacctct     120

tctcatagca aaaaaaatac agcccataaa acacccgtat catccgacca accaattgaa     180

gatccatacc cagtaacatt tccaattgat gtagtttata cttgggtaga ttcagatgat     240

gaaaaattca atgaagaacg cctaaagttt caaaattcaa gcacatctga gactctacaa     300

ggcaaagcag aaagcaccga tattgcaaga ttccaatcac gcgacgaatt aaaatattcg     360

attcgaagcc tgatgaagta tgccccatgg gtaaatcata tttacattgt aacaaatggt     420

caaataccaa aatggttaga taccaacaat acaaaggtaa cgattatccc tcactcaact     480

attatcgaca gtcaatttct ccctactttt aattctcacg tcattgaatc ctctctatat     540

aaaatcccag gattatcaga gcattacatt tatttcaatg atgatgtcat gctagctaga     600

gatttaagcc catcttattt ctttacaagc agcggattag caaaactgtt tattaccaac     660

tctcgtctac caaatggcta taagaatgtg aaagacacac caacccaatg ggcctcaaaa     720

aattcccgtg agcttttaca tgcagaaaca ggattttggg ctgaagccat gtttgcacat     780

acttttcatc cacaacgtaa aagtgtacat gaatctattg aacacctatg gcatgaacaa     840

ttaaatgttt gtcgtcaaaa ccgtttccgt gatatttcag atattaacat ggcgacattc     900

ctgcaccacc attttgccat tttgacaggc caagctcttg ctacacgcac taaatgtatt     960

tactttaaca ttcgctctcc tcaagcagct cagcattaca aaacattatt agctcgaaaa    1020

ggaagcgaat acagcccaca ttctatctgc ttaaatgatc atacatcgag caataaaaat    1080

attttatcta attacgaagc caaattacaa agctttttag aaacatacta tccagatgta    1140

tcagaagcag aaattctc                                                  1158


<210> 21
<211> 987
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA deltaN58 deltaC99-CP-X (987)

<400> 21
ccaattgaag atccataccc agtaacattt ccaattgatg tagtttatac ttgggtagat      60

tcagatgatg aaaaattcaa tgaagaacgc ctaaagtttc aaaattcaag cacatctgag     120

actctacaag gcaaagcaga aagcaccgat attgcaagat tccaatcacg cgacgaatta     180

aaatattcga ttcgaagcct gatgaagtat gccccatggg taaatcatat ttacattgta     240

acaaatggtc aaataccaaa atggttagat accaacaata caaaggtaac gattatccct     300

cactcaacta ttatcgacag tcaatttctc cctactttta attctcacgt cattgaatcc     360

tctctatata aaatcccagg attatcagag cattacattt atttcaatga tgatgtcatg     420

ctagctagag atttaagccc atcttatttc tttacaagca gcggattagc aaaactgttt     480

attaccaact ctcgtctacc aaatggctat aagaatgtga aagacacacc aacccaatgg     540

gcctcaaaaa attcccgtga gcttttacat gcagaaacag gattttgggc tgaagccatg     600

tttgcacata cttttcatcc acaacgtaaa agtgtacatg aatctattga acacctatgg     660

catgaacaat taaatgtttg tcgtcaaaac cgtttccgtg atatttcaga tattaacatg     720

gcgacattcc tgcaccacca ttttgccatt ttgacaggcc aagctcttgc tacacgcact     780

aaatgtattt actttaacat tcgctctcct caagcagctc agcattacaa aacattatta     840

gctcgaaaag gaagcgaata cagcccacat tctatctgct taaatgatca tacatcgagc     900

aataaaaata ttttatctaa ttacgaagcc aaattacaaa gctttttaga aacatactat     960

ccagatgtat cagaagcaga aattctc                                         987


<210> 22
<211> 1233
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA deltaN65deltaC10-CP-X (1233)

<400> 22
gtaacatttc caattgatgt agtttatact tgggtagatt cagatgatga aaaattcaat      60

gaagaacgcc taaagtttca aaattcaagc acatctgaga ctctacaagg caaagcagaa     120

agcaccgata ttgcaagatt ccaatcacgc gacgaattaa aatattcgat tcgaagcctg     180

atgaagtatg ccccatgggt aaatcatatt tacattgtaa caaatggtca aataccaaaa     240

tggttagata ccaacaatac aaaggtaacg attatccctc actcaactat tatcgacagt     300

caatttctcc ctacttttaa ttctcacgtc attgaatcct ctctatataa aatcccagga     360

ttatcagagc attacattta tttcaatgat gatgtcatgc tagctagaga tttaagccca     420

tcttatttct ttacaagcag cggattagca aaactgttta ttaccaactc tcgtctacca     480

aatggctata agaatgtgaa agacacacca acccaatggg cctcaaaaaa ttcccgtgag     540

cttttacatg cagaaacagg attttgggct gaagccatgt ttgcacatac ttttcatcca     600

caacgtaaaa gtgtacatga atctattgaa cacctatggc atgaacaatt aaatgtttgt     660

cgtcaaaacc gtttccgtga tatttcagat attaacatgg cgacattcct gcaccaccat     720

tttgccattt tgacaggcca agctcttgct acacgcacta aatgtattta ctttaacatt     780

cgctctcctc aagcagctca gcattacaaa acattattag ctcgaaaagg aagcgaatac     840

agcccacatt ctatctgctt aaatgatcat acatcgagca ataaaaatat tttatctaat     900

tacgaagcca aattacaaag ctttttagaa acatactatc cagatgtatc agaagcagaa     960

attctccttc ctactaaatc tgaagtagct gaattagtta aacataaaga ttatttaact    1020

gtatatacta aattattacc tattatcaat aagcagctgg tcaataaata taataaacct    1080

tattcatatc ttttctatta tttaggttta tctgcccggt ttttatttga agaaacgcaa    1140

caagaacact accgggaaac tgctgaagaa aatttacaaa tcttttgtgg cctaaaccca    1200

aaacatacac tagccctcaa atacttagcg gat                                 1233


<210> 23
<211> 960
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA deltaN67deltaC99-CP-X (960)

<400> 23
tttccaattg atgtagttta tacttgggta gattcagatg atgaaaaatt caatgaagaa      60

cgcctaaagt ttcaaaattc aagcacatct gagactctac aaggcaaagc agaaagcacc     120

gatattgcaa gattccaatc acgcgacgaa ttaaaatatt cgattcgaag cctgatgaag     180

tatgccccat gggtaaatca tatttacatt gtaacaaatg gtcaaatacc aaaatggtta     240

gataccaaca atacaaaggt aacgattatc cctcactcaa ctattatcga cagtcaattt     300

ctccctactt ttaattctca cgtcattgaa tcctctctat ataaaatccc aggattatca     360

gagcattaca tttatttcaa tgatgatgtc atgctagcta gagatttaag cccatcttat     420

ttctttacaa gcagcggatt agcaaaactg tttattacca actctcgtct accaaatggc     480

tataagaatg tgaaagacac accaacccaa tgggcctcaa aaaattcccg tgagctttta     540

catgcagaaa caggattttg ggctgaagcc atgtttgcac atacttttca tccacaacgt     600

aaaagtgtac atgaatctat tgaacaccta tggcatgaac aattaaatgt ttgtcgtcaa     660

aaccgtttcc gtgatatttc agatattaac atggcgacat tcctgcacca ccattttgcc     720

attttgacag gccaagctct tgctacacgc actaaatgta tttactttaa cattcgctct     780

cctcaagcag ctcagcatta caaaacatta ttagctcgaa aaggaagcga atacagccca     840

cattctatct gcttaaatga tcatacatcg agcaataaaa atattttatc taattacgaa     900

gccaaattac aaagcttttt agaaacatac tatccagatg tatcagaagc agaaattctc     960


<210> 24
<211> 485
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS CP-X/CsxA full-length (485)

<400> 24
Ile Met Ser Lys Ile Ser Lys Leu Val Thr His Pro Asn Leu Phe Phe 
1               5                   10                  15      
Arg Asp Tyr Phe Leu Lys Lys Ala Pro Leu Asn Tyr Gly Glu Asn Ile 
            20                  25                  30          
Lys Pro Leu Pro Val Glu Thr Ser Ser His Ser Lys Lys Asn Thr Ala 
        35                  40                  45              
His Lys Thr Pro Val Ser Ser Asp Gln Pro Ile Glu Asp Pro Tyr Pro 
    50                  55                  60                  
Val Thr Phe Pro Ile Asp Val Val Tyr Thr Trp Val Asp Ser Asp Asp 
65                  70                  75                  80  
Glu Lys Phe Asn Glu Glu Arg Leu Lys Phe Gln Asn Ser Ser Thr Ser 
                85                  90                  95      
Glu Thr Leu Gln Gly Lys Ala Glu Ser Thr Asp Ile Ala Arg Phe Gln 
            100                 105                 110         
Ser Arg Asp Glu Leu Lys Tyr Ser Ile Arg Ser Leu Met Lys Tyr Ala 
        115                 120                 125             
Pro Trp Val Asn His Ile Tyr Ile Val Thr Asn Gly Gln Ile Pro Lys 
    130                 135                 140                 
Trp Leu Asp Thr Asn Asn Thr Lys Val Thr Ile Ile Pro His Ser Thr 
145                 150                 155                 160 
Ile Ile Asp Ser Gln Phe Leu Pro Thr Phe Asn Ser His Val Ile Glu 
                165                 170                 175     
Ser Ser Leu Tyr Lys Ile Pro Gly Leu Ser Glu His Tyr Ile Tyr Phe 
            180                 185                 190         
Asn Asp Asp Val Met Leu Ala Arg Asp Leu Ser Pro Ser Tyr Phe Phe 
        195                 200                 205             
Thr Ser Ser Gly Leu Ala Lys Leu Phe Ile Thr Asn Ser Arg Leu Pro 
    210                 215                 220                 
Asn Gly Tyr Lys Asn Val Lys Asp Thr Pro Thr Gln Trp Ala Ser Lys 
225                 230                 235                 240 
Asn Ser Arg Glu Leu Leu His Ala Glu Thr Gly Phe Trp Ala Glu Ala 
                245                 250                 255     
Met Phe Ala His Thr Phe His Pro Gln Arg Lys Ser Val His Glu Ser 
            260                 265                 270         
Ile Glu His Leu Trp His Glu Gln Leu Asn Val Cys Arg Gln Asn Arg 
        275                 280                 285             
Phe Arg Asp Ile Ser Asp Ile Asn Met Ala Thr Phe Leu His His His 
    290                 295                 300                 
Phe Ala Ile Leu Thr Gly Gln Ala Leu Ala Thr Arg Thr Lys Cys Ile 
305                 310                 315                 320 
Tyr Phe Asn Ile Arg Ser Pro Gln Ala Ala Gln His Tyr Lys Thr Leu 
                325                 330                 335     
Leu Ala Arg Lys Gly Ser Glu Tyr Ser Pro His Ser Ile Cys Leu Asn 
            340                 345                 350         
Asp His Thr Ser Ser Asn Lys Asn Ile Leu Ser Asn Tyr Glu Ala Lys 
        355                 360                 365             
Leu Gln Ser Phe Leu Glu Thr Tyr Tyr Pro Asp Val Ser Glu Ala Glu 
    370                 375                 380                 
Ile Leu Leu Pro Thr Lys Ser Glu Val Ala Glu Leu Val Lys His Lys 
385                 390                 395                 400 
Asp Tyr Leu Thr Val Tyr Thr Lys Leu Leu Pro Ile Ile Asn Lys Gln 
                405                 410                 415     
Leu Val Asn Lys Tyr Asn Lys Pro Tyr Ser Tyr Leu Phe Tyr Tyr Leu 
            420                 425                 430         
Gly Leu Ser Ala Arg Phe Leu Phe Glu Glu Thr Gln Gln Glu His Tyr 
        435                 440                 445             
Arg Glu Thr Ala Glu Glu Asn Leu Gln Ile Phe Cys Gly Leu Asn Pro 
    450                 455                 460                 
Lys His Thr Leu Ala Leu Lys Tyr Leu Ala Asp Val Thr Leu Thr Ser 
465                 470                 475                 480 
Gln Pro Ser Gly Gln 
                485 

<210> 25
<211> 428
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS deltaN58-CP-X (428)

<400> 25
Pro Ile Glu Asp Pro Tyr Pro Val Thr Phe Pro Ile Asp Val Val Tyr 
1               5                   10                  15      
Thr Trp Val Asp Ser Asp Asp Glu Lys Phe Asn Glu Glu Arg Leu Lys 
            20                  25                  30          
Phe Gln Asn Ser Ser Thr Ser Glu Thr Leu Gln Gly Lys Ala Glu Ser 
        35                  40                  45              
Thr Asp Ile Ala Arg Phe Gln Ser Arg Asp Glu Leu Lys Tyr Ser Ile 
    50                  55                  60                  
Arg Ser Leu Met Lys Tyr Ala Pro Trp Val Asn His Ile Tyr Ile Val 
65                  70                  75                  80  
Thr Asn Gly Gln Ile Pro Lys Trp Leu Asp Thr Asn Asn Thr Lys Val 
                85                  90                  95      
Thr Ile Ile Pro His Ser Thr Ile Ile Asp Ser Gln Phe Leu Pro Thr 
            100                 105                 110         
Phe Asn Ser His Val Ile Glu Ser Ser Leu Tyr Lys Ile Pro Gly Leu 
        115                 120                 125             
Ser Glu His Tyr Ile Tyr Phe Asn Asp Asp Val Met Leu Ala Arg Asp 
    130                 135                 140                 
Leu Ser Pro Ser Tyr Phe Phe Thr Ser Ser Gly Leu Ala Lys Leu Phe 
145                 150                 155                 160 
Ile Thr Asn Ser Arg Leu Pro Asn Gly Tyr Lys Asn Val Lys Asp Thr 
                165                 170                 175     
Pro Thr Gln Trp Ala Ser Lys Asn Ser Arg Glu Leu Leu His Ala Glu 
            180                 185                 190         
Thr Gly Phe Trp Ala Glu Ala Met Phe Ala His Thr Phe His Pro Gln 
        195                 200                 205             
Arg Lys Ser Val His Glu Ser Ile Glu His Leu Trp His Glu Gln Leu 
    210                 215                 220                 
Asn Val Cys Arg Gln Asn Arg Phe Arg Asp Ile Ser Asp Ile Asn Met 
225                 230                 235                 240 
Ala Thr Phe Leu His His His Phe Ala Ile Leu Thr Gly Gln Ala Leu 
                245                 250                 255     
Ala Thr Arg Thr Lys Cys Ile Tyr Phe Asn Ile Arg Ser Pro Gln Ala 
            260                 265                 270         
Ala Gln His Tyr Lys Thr Leu Leu Ala Arg Lys Gly Ser Glu Tyr Ser 
        275                 280                 285             
Pro His Ser Ile Cys Leu Asn Asp His Thr Ser Ser Asn Lys Asn Ile 
    290                 295                 300                 
Leu Ser Asn Tyr Glu Ala Lys Leu Gln Ser Phe Leu Glu Thr Tyr Tyr 
305                 310                 315                 320 
Pro Asp Val Ser Glu Ala Glu Ile Leu Leu Pro Thr Lys Ser Glu Val 
                325                 330                 335     
Ala Glu Leu Val Lys His Lys Asp Tyr Leu Thr Val Tyr Thr Lys Leu 
            340                 345                 350         
Leu Pro Ile Ile Asn Lys Gln Leu Val Asn Lys Tyr Asn Lys Pro Tyr 
        355                 360                 365             
Ser Tyr Leu Phe Tyr Tyr Leu Gly Leu Ser Ala Arg Phe Leu Phe Glu 
    370                 375                 380                 
Glu Thr Gln Gln Glu His Tyr Arg Glu Thr Ala Glu Glu Asn Leu Gln 
385                 390                 395                 400 
Ile Phe Cys Gly Leu Asn Pro Lys His Thr Leu Ala Leu Lys Tyr Leu 
                405                 410                 415     
Ala Asp Val Thr Leu Thr Ser Gln Pro Ser Gly Gln 
            420                 425             

<210> 26
<211> 382
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS deltaN104-CP-X (382)

<400> 26
Glu Ser Thr Asp Ile Ala Arg Phe Gln Ser Arg Asp Glu Leu Lys Tyr 
1               5                   10                  15      
Ser Ile Arg Ser Leu Met Lys Tyr Ala Pro Trp Val Asn His Ile Tyr 
            20                  25                  30          
Ile Val Thr Asn Gly Gln Ile Pro Lys Trp Leu Asp Thr Asn Asn Thr 
        35                  40                  45              
Lys Val Thr Ile Ile Pro His Ser Thr Ile Ile Asp Ser Gln Phe Leu 
    50                  55                  60                  
Pro Thr Phe Asn Ser His Val Ile Glu Ser Ser Leu Tyr Lys Ile Pro 
65                  70                  75                  80  
Gly Leu Ser Glu His Tyr Ile Tyr Phe Asn Asp Asp Val Met Leu Ala 
                85                  90                  95      
Arg Asp Leu Ser Pro Ser Tyr Phe Phe Thr Ser Ser Gly Leu Ala Lys 
            100                 105                 110         
Leu Phe Ile Thr Asn Ser Arg Leu Pro Asn Gly Tyr Lys Asn Val Lys 
        115                 120                 125             
Asp Thr Pro Thr Gln Trp Ala Ser Lys Asn Ser Arg Glu Leu Leu His 
    130                 135                 140                 
Ala Glu Thr Gly Phe Trp Ala Glu Ala Met Phe Ala His Thr Phe His 
145                 150                 155                 160 
Pro Gln Arg Lys Ser Val His Glu Ser Ile Glu His Leu Trp His Glu 
                165                 170                 175     
Gln Leu Asn Val Cys Arg Gln Asn Arg Phe Arg Asp Ile Ser Asp Ile 
            180                 185                 190         
Asn Met Ala Thr Phe Leu His His His Phe Ala Ile Leu Thr Gly Gln 
        195                 200                 205             
Ala Leu Ala Thr Arg Thr Lys Cys Ile Tyr Phe Asn Ile Arg Ser Pro 
    210                 215                 220                 
Gln Ala Ala Gln His Tyr Lys Thr Leu Leu Ala Arg Lys Gly Ser Glu 
225                 230                 235                 240 
Tyr Ser Pro His Ser Ile Cys Leu Asn Asp His Thr Ser Ser Asn Lys 
                245                 250                 255     
Asn Ile Leu Ser Asn Tyr Glu Ala Lys Leu Gln Ser Phe Leu Glu Thr 
            260                 265                 270         
Tyr Tyr Pro Asp Val Ser Glu Ala Glu Ile Leu Leu Pro Thr Lys Ser 
        275                 280                 285             
Glu Val Ala Glu Leu Val Lys His Lys Asp Tyr Leu Thr Val Tyr Thr 
    290                 295                 300                 
Lys Leu Leu Pro Ile Ile Asn Lys Gln Leu Val Asn Lys Tyr Asn Lys 
305                 310                 315                 320 
Pro Tyr Ser Tyr Leu Phe Tyr Tyr Leu Gly Leu Ser Ala Arg Phe Leu 
                325                 330                 335     
Phe Glu Glu Thr Gln Gln Glu His Tyr Arg Glu Thr Ala Glu Glu Asn 
            340                 345                 350         
Leu Gln Ile Phe Cys Gly Leu Asn Pro Lys His Thr Leu Ala Leu Lys 
        355                 360                 365             
Tyr Leu Ala Asp Val Thr Leu Thr Ser Gln Pro Ser Gly Gln 
    370                 375                 380         

<210> 27
<211> 311
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS deltaC174-CP-X (311)

<400> 27
Ile Met Ser Lys Ile Ser Lys Leu Val Thr His Pro Asn Leu Phe Phe 
1               5                   10                  15      
Arg Asp Tyr Phe Leu Lys Lys Ala Pro Leu Asn Tyr Gly Glu Asn Ile 
            20                  25                  30          
Lys Pro Leu Pro Val Glu Thr Ser Ser His Ser Lys Lys Asn Thr Ala 
        35                  40                  45              
His Lys Thr Pro Val Ser Ser Asp Gln Pro Ile Glu Asp Pro Tyr Pro 
    50                  55                  60                  
Val Thr Phe Pro Ile Asp Val Val Tyr Thr Trp Val Asp Ser Asp Asp 
65                  70                  75                  80  
Glu Lys Phe Asn Glu Glu Arg Leu Lys Phe Gln Asn Ser Ser Thr Ser 
                85                  90                  95      
Glu Thr Leu Gln Gly Lys Ala Glu Ser Thr Asp Ile Ala Arg Phe Gln 
            100                 105                 110         
Ser Arg Asp Glu Leu Lys Tyr Ser Ile Arg Ser Leu Met Lys Tyr Ala 
        115                 120                 125             
Pro Trp Val Asn His Ile Tyr Ile Val Thr Asn Gly Gln Ile Pro Lys 
    130                 135                 140                 
Trp Leu Asp Thr Asn Asn Thr Lys Val Thr Ile Ile Pro His Ser Thr 
145                 150                 155                 160 
Ile Ile Asp Ser Gln Phe Leu Pro Thr Phe Asn Ser His Val Ile Glu 
                165                 170                 175     
Ser Ser Leu Tyr Lys Ile Pro Gly Leu Ser Glu His Tyr Ile Tyr Phe 
            180                 185                 190         
Asn Asp Asp Val Met Leu Ala Arg Asp Leu Ser Pro Ser Tyr Phe Phe 
        195                 200                 205             
Thr Ser Ser Gly Leu Ala Lys Leu Phe Ile Thr Asn Ser Arg Leu Pro 
    210                 215                 220                 
Asn Gly Tyr Lys Asn Val Lys Asp Thr Pro Thr Gln Trp Ala Ser Lys 
225                 230                 235                 240 
Asn Ser Arg Glu Leu Leu His Ala Glu Thr Gly Phe Trp Ala Glu Ala 
                245                 250                 255     
Met Phe Ala His Thr Phe His Pro Gln Arg Lys Ser Val His Glu Ser 
            260                 265                 270         
Ile Glu His Leu Trp His Glu Gln Leu Asn Val Cys Arg Gln Asn Arg 
        275                 280                 285             
Phe Arg Asp Ile Ser Asp Ile Asn Met Ala Thr Phe Leu His His His 
    290                 295                 300                 
Phe Ala Ile Leu Thr Gly Gln 
305                 310     

<210> 28
<211> 386
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS deltaC99-CP-X (386)

<400> 28
Ile Met Ser Lys Ile Ser Lys Leu Val Thr His Pro Asn Leu Phe Phe 
1               5                   10                  15      
Arg Asp Tyr Phe Leu Lys Lys Ala Pro Leu Asn Tyr Gly Glu Asn Ile 
            20                  25                  30          
Lys Pro Leu Pro Val Glu Thr Ser Ser His Ser Lys Lys Asn Thr Ala 
        35                  40                  45              
His Lys Thr Pro Val Ser Ser Asp Gln Pro Ile Glu Asp Pro Tyr Pro 
    50                  55                  60                  
Val Thr Phe Pro Ile Asp Val Val Tyr Thr Trp Val Asp Ser Asp Asp 
65                  70                  75                  80  
Glu Lys Phe Asn Glu Glu Arg Leu Lys Phe Gln Asn Ser Ser Thr Ser 
                85                  90                  95      
Glu Thr Leu Gln Gly Lys Ala Glu Ser Thr Asp Ile Ala Arg Phe Gln 
            100                 105                 110         
Ser Arg Asp Glu Leu Lys Tyr Ser Ile Arg Ser Leu Met Lys Tyr Ala 
        115                 120                 125             
Pro Trp Val Asn His Ile Tyr Ile Val Thr Asn Gly Gln Ile Pro Lys 
    130                 135                 140                 
Trp Leu Asp Thr Asn Asn Thr Lys Val Thr Ile Ile Pro His Ser Thr 
145                 150                 155                 160 
Ile Ile Asp Ser Gln Phe Leu Pro Thr Phe Asn Ser His Val Ile Glu 
                165                 170                 175     
Ser Ser Leu Tyr Lys Ile Pro Gly Leu Ser Glu His Tyr Ile Tyr Phe 
            180                 185                 190         
Asn Asp Asp Val Met Leu Ala Arg Asp Leu Ser Pro Ser Tyr Phe Phe 
        195                 200                 205             
Thr Ser Ser Gly Leu Ala Lys Leu Phe Ile Thr Asn Ser Arg Leu Pro 
    210                 215                 220                 
Asn Gly Tyr Lys Asn Val Lys Asp Thr Pro Thr Gln Trp Ala Ser Lys 
225                 230                 235                 240 
Asn Ser Arg Glu Leu Leu His Ala Glu Thr Gly Phe Trp Ala Glu Ala 
                245                 250                 255     
Met Phe Ala His Thr Phe His Pro Gln Arg Lys Ser Val His Glu Ser 
            260                 265                 270         
Ile Glu His Leu Trp His Glu Gln Leu Asn Val Cys Arg Gln Asn Arg 
        275                 280                 285             
Phe Arg Asp Ile Ser Asp Ile Asn Met Ala Thr Phe Leu His His His 
    290                 295                 300                 
Phe Ala Ile Leu Thr Gly Gln Ala Leu Ala Thr Arg Thr Lys Cys Ile 
305                 310                 315                 320 
Tyr Phe Asn Ile Arg Ser Pro Gln Ala Ala Gln His Tyr Lys Thr Leu 
                325                 330                 335     
Leu Ala Arg Lys Gly Ser Glu Tyr Ser Pro His Ser Ile Cys Leu Asn 
            340                 345                 350         
Asp His Thr Ser Ser Asn Lys Asn Ile Leu Ser Asn Tyr Glu Ala Lys 
        355                 360                 365             
Leu Gln Ser Phe Leu Glu Thr Tyr Tyr Pro Asp Val Ser Glu Ala Glu 
    370                 375                 380                 
Ile Leu 
385     

<210> 29
<211> 329
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS deltaN58deltaC99-CP-X (329)

<400> 29
Pro Ile Glu Asp Pro Tyr Pro Val Thr Phe Pro Ile Asp Val Val Tyr 
1               5                   10                  15      
Thr Trp Val Asp Ser Asp Asp Glu Lys Phe Asn Glu Glu Arg Leu Lys 
            20                  25                  30          
Phe Gln Asn Ser Ser Thr Ser Glu Thr Leu Gln Gly Lys Ala Glu Ser 
        35                  40                  45              
Thr Asp Ile Ala Arg Phe Gln Ser Arg Asp Glu Leu Lys Tyr Ser Ile 
    50                  55                  60                  
Arg Ser Leu Met Lys Tyr Ala Pro Trp Val Asn His Ile Tyr Ile Val 
65                  70                  75                  80  
Thr Asn Gly Gln Ile Pro Lys Trp Leu Asp Thr Asn Asn Thr Lys Val 
                85                  90                  95      
Thr Ile Ile Pro His Ser Thr Ile Ile Asp Ser Gln Phe Leu Pro Thr 
            100                 105                 110         
Phe Asn Ser His Val Ile Glu Ser Ser Leu Tyr Lys Ile Pro Gly Leu 
        115                 120                 125             
Ser Glu His Tyr Ile Tyr Phe Asn Asp Asp Val Met Leu Ala Arg Asp 
    130                 135                 140                 
Leu Ser Pro Ser Tyr Phe Phe Thr Ser Ser Gly Leu Ala Lys Leu Phe 
145                 150                 155                 160 
Ile Thr Asn Ser Arg Leu Pro Asn Gly Tyr Lys Asn Val Lys Asp Thr 
                165                 170                 175     
Pro Thr Gln Trp Ala Ser Lys Asn Ser Arg Glu Leu Leu His Ala Glu 
            180                 185                 190         
Thr Gly Phe Trp Ala Glu Ala Met Phe Ala His Thr Phe His Pro Gln 
        195                 200                 205             
Arg Lys Ser Val His Glu Ser Ile Glu His Leu Trp His Glu Gln Leu 
    210                 215                 220                 
Asn Val Cys Arg Gln Asn Arg Phe Arg Asp Ile Ser Asp Ile Asn Met 
225                 230                 235                 240 
Ala Thr Phe Leu His His His Phe Ala Ile Leu Thr Gly Gln Ala Leu 
                245                 250                 255     
Ala Thr Arg Thr Lys Cys Ile Tyr Phe Asn Ile Arg Ser Pro Gln Ala 
            260                 265                 270         
Ala Gln His Tyr Lys Thr Leu Leu Ala Arg Lys Gly Ser Glu Tyr Ser 
        275                 280                 285             
Pro His Ser Ile Cys Leu Asn Asp His Thr Ser Ser Asn Lys Asn Ile 
    290                 295                 300                 
Leu Ser Asn Tyr Glu Ala Lys Leu Gln Ser Phe Leu Glu Thr Tyr Tyr 
305                 310                 315                 320 
Pro Asp Val Ser Glu Ala Glu Ile Leu 
                325                 

<210> 30
<211> 411
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS deltaN65deltaC10-CP-X (411)

<400> 30
Val Thr Phe Pro Ile Asp Val Val Tyr Thr Trp Val Asp Ser Asp Asp 
1               5                   10                  15      
Glu Lys Phe Asn Glu Glu Arg Leu Lys Phe Gln Asn Ser Ser Thr Ser 
            20                  25                  30          
Glu Thr Leu Gln Gly Lys Ala Glu Ser Thr Asp Ile Ala Arg Phe Gln 
        35                  40                  45              
Ser Arg Asp Glu Leu Lys Tyr Ser Ile Arg Ser Leu Met Lys Tyr Ala 
    50                  55                  60                  
Pro Trp Val Asn His Ile Tyr Ile Val Thr Asn Gly Gln Ile Pro Lys 
65                  70                  75                  80  
Trp Leu Asp Thr Asn Asn Thr Lys Val Thr Ile Ile Pro His Ser Thr 
                85                  90                  95      
Ile Ile Asp Ser Gln Phe Leu Pro Thr Phe Asn Ser His Val Ile Glu 
            100                 105                 110         
Ser Ser Leu Tyr Lys Ile Pro Gly Leu Ser Glu His Tyr Ile Tyr Phe 
        115                 120                 125             
Asn Asp Asp Val Met Leu Ala Arg Asp Leu Ser Pro Ser Tyr Phe Phe 
    130                 135                 140                 
Thr Ser Ser Gly Leu Ala Lys Leu Phe Ile Thr Asn Ser Arg Leu Pro 
145                 150                 155                 160 
Asn Gly Tyr Lys Asn Val Lys Asp Thr Pro Thr Gln Trp Ala Ser Lys 
                165                 170                 175     
Asn Ser Arg Glu Leu Leu His Ala Glu Thr Gly Phe Trp Ala Glu Ala 
            180                 185                 190         
Met Phe Ala His Thr Phe His Pro Gln Arg Lys Ser Val His Glu Ser 
        195                 200                 205             
Ile Glu His Leu Trp His Glu Gln Leu Asn Val Cys Arg Gln Asn Arg 
    210                 215                 220                 
Phe Arg Asp Ile Ser Asp Ile Asn Met Ala Thr Phe Leu His His His 
225                 230                 235                 240 
Phe Ala Ile Leu Thr Gly Gln Ala Leu Ala Thr Arg Thr Lys Cys Ile 
                245                 250                 255     
Tyr Phe Asn Ile Arg Ser Pro Gln Ala Ala Gln His Tyr Lys Thr Leu 
            260                 265                 270         
Leu Ala Arg Lys Gly Ser Glu Tyr Ser Pro His Ser Ile Cys Leu Asn 
        275                 280                 285             
Asp His Thr Ser Ser Asn Lys Asn Ile Leu Ser Asn Tyr Glu Ala Lys 
    290                 295                 300                 
Leu Gln Ser Phe Leu Glu Thr Tyr Tyr Pro Asp Val Ser Glu Ala Glu 
305                 310                 315                 320 
Ile Leu Leu Pro Thr Lys Ser Glu Val Ala Glu Leu Val Lys His Lys 
                325                 330                 335     
Asp Tyr Leu Thr Val Tyr Thr Lys Leu Leu Pro Ile Ile Asn Lys Gln 
            340                 345                 350         
Leu Val Asn Lys Tyr Asn Lys Pro Tyr Ser Tyr Leu Phe Tyr Tyr Leu 
        355                 360                 365             
Gly Leu Ser Ala Arg Phe Leu Phe Glu Glu Thr Gln Gln Glu His Tyr 
    370                 375                 380                 
Arg Glu Thr Ala Glu Glu Asn Leu Gln Ile Phe Cys Gly Leu Asn Pro 
385                 390                 395                 400 
Lys His Thr Leu Ala Leu Lys Tyr Leu Ala Asp 
                405                 410     

<210> 31
<211> 320
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS deltaN67deltaC99-CP-X (320)

<400> 31
Phe Pro Ile Asp Val Val Tyr Thr Trp Val Asp Ser Asp Asp Glu Lys 
1               5                   10                  15      
Phe Asn Glu Glu Arg Leu Lys Phe Gln Asn Ser Ser Thr Ser Glu Thr 
            20                  25                  30          
Leu Gln Gly Lys Ala Glu Ser Thr Asp Ile Ala Arg Phe Gln Ser Arg 
        35                  40                  45              
Asp Glu Leu Lys Tyr Ser Ile Arg Ser Leu Met Lys Tyr Ala Pro Trp 
    50                  55                  60                  
Val Asn His Ile Tyr Ile Val Thr Asn Gly Gln Ile Pro Lys Trp Leu 
65                  70                  75                  80  
Asp Thr Asn Asn Thr Lys Val Thr Ile Ile Pro His Ser Thr Ile Ile 
                85                  90                  95      
Asp Ser Gln Phe Leu Pro Thr Phe Asn Ser His Val Ile Glu Ser Ser 
            100                 105                 110         
Leu Tyr Lys Ile Pro Gly Leu Ser Glu His Tyr Ile Tyr Phe Asn Asp 
        115                 120                 125             
Asp Val Met Leu Ala Arg Asp Leu Ser Pro Ser Tyr Phe Phe Thr Ser 
    130                 135                 140                 
Ser Gly Leu Ala Lys Leu Phe Ile Thr Asn Ser Arg Leu Pro Asn Gly 
145                 150                 155                 160 
Tyr Lys Asn Val Lys Asp Thr Pro Thr Gln Trp Ala Ser Lys Asn Ser 
                165                 170                 175     
Arg Glu Leu Leu His Ala Glu Thr Gly Phe Trp Ala Glu Ala Met Phe 
            180                 185                 190         
Ala His Thr Phe His Pro Gln Arg Lys Ser Val His Glu Ser Ile Glu 
        195                 200                 205             
His Leu Trp His Glu Gln Leu Asn Val Cys Arg Gln Asn Arg Phe Arg 
    210                 215                 220                 
Asp Ile Ser Asp Ile Asn Met Ala Thr Phe Leu His His His Phe Ala 
225                 230                 235                 240 
Ile Leu Thr Gly Gln Ala Leu Ala Thr Arg Thr Lys Cys Ile Tyr Phe 
                245                 250                 255     
Asn Ile Arg Ser Pro Gln Ala Ala Gln His Tyr Lys Thr Leu Leu Ala 
            260                 265                 270         
Arg Lys Gly Ser Glu Tyr Ser Pro His Ser Ile Cys Leu Asn Asp His 
        275                 280                 285             
Thr Ser Ser Asn Lys Asn Ile Leu Ser Asn Tyr Glu Ala Lys Leu Gln 
    290                 295                 300                 
Ser Phe Leu Glu Thr Tyr Tyr Pro Asp Val Ser Glu Ala Glu Ile Leu 
305                 310                 315                 320 



<210> 32
<211> 1119
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> UDP-GlcNAc-Epimerase (NmA) cloned from Neisseria meningitidis
      serogroup A, coding sequence >UDP-GlcNAc-Epimerase-NmA (AF019760
      REGION: 479..1597)

<400> 32
atgaaagtct taaccgtctt tggcactcgc cctgaagcta ttaaaatggc gcctgtaatt      60

ctagagttac aaaaacataa cacaattact tcaaaagttt gcattactgc acagcatcgt     120

gaaatgctag atcaggtttt gagcctattc gaaatcaaag ctgattatga tttaaatatc     180

atgaaaccca accagagcct acaagaaatc acaacaaata tcatctcaag ccttaccgat     240

gttcttgaag atttcaaacc tgactgcgtc cttgctcacg gagacaccac aacaactttt     300

gcagctagcc ttgctgcatt ctatcaaaaa atacctgttg gccacattga agcaggcctg     360

agaacttata atttatactc tccttggcca gaggaagcaa ataggcgttt aacaagcgtt     420

ctaagccagt ggcattttgc acctactgaa gattctaaaa ataacttact atctgaatca     480

ataccttctg acaaagttat tgttactgga aatactgtca tagatgcact aatggtatct     540

ctagaaaaac taaaaataac tacaattaaa aaacaaatgg aacaagcttt tccatttatt     600

caggacaact ctaaagtaat tttaattacc gctcatagaa gagaaaatca tggggaaggt     660

attaaaaata ttggactttc tatcttagaa ttagctaaaa aatacccaac attctctttt     720

gtgattccgc tccatttaaa tcctaacgtt agaaaaccaa ttcaagattt attatcctct     780

gtgcacaatg ttcatcttat tgagccacaa gaatacttac cattcgtata tttaatgtct     840

aaaagccata taatattaag tgattcaggc ggcatacaag aagaagctcc atccctagga     900

aaaccagttc ttgtattaag agatactaca gaacgtcctg aagctgtagc tgcaggaact     960

gtaaaattag taggttctga aactcaaaat attattgaga gctttacaca actaattgaa    1020

taccctgaat attatgaaaa aatggctaat attgaaaacc cttacgggat aggtaatgcc    1080

tcaaaaatca ttgtagaaac tttattaaag aatagataa                           1119


<210> 33
<211> 372
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> UDP-GlcNAc-Epimerase (NmA) cloned from Neisseria meningitidis
      serogroup A amino acid sequence >UDP-GlcNAc-Epimerase-NmA
      (AAC38285).pro

<400> 33
Met Lys Val Leu Thr Val Phe Gly Thr Arg Pro Glu Ala Ile Lys Met 
1               5                   10                  15      
Ala Pro Val Ile Leu Glu Leu Gln Lys His Asn Thr Ile Thr Ser Lys 
            20                  25                  30          
Val Cys Ile Thr Ala Gln His Arg Glu Met Leu Asp Gln Val Leu Ser 
        35                  40                  45              
Leu Phe Glu Ile Lys Ala Asp Tyr Asp Leu Asn Ile Met Lys Pro Asn 
    50                  55                  60                  
Gln Ser Leu Gln Glu Ile Thr Thr Asn Ile Ile Ser Ser Leu Thr Asp 
65                  70                  75                  80  
Val Leu Glu Asp Phe Lys Pro Asp Cys Val Leu Ala His Gly Asp Thr 
                85                  90                  95      
Thr Thr Thr Phe Ala Ala Ser Leu Ala Ala Phe Tyr Gln Lys Ile Pro 
            100                 105                 110         
Val Gly His Ile Glu Ala Gly Leu Arg Thr Tyr Asn Leu Tyr Ser Pro 
        115                 120                 125             
Trp Pro Glu Glu Ala Asn Arg Arg Leu Thr Ser Val Leu Ser Gln Trp 
    130                 135                 140                 
His Phe Ala Pro Thr Glu Asp Ser Lys Asn Asn Leu Leu Ser Glu Ser 
145                 150                 155                 160 
Ile Pro Ser Asp Lys Val Ile Val Thr Gly Asn Thr Val Ile Asp Ala 
                165                 170                 175     
Leu Met Val Ser Leu Glu Lys Leu Lys Ile Thr Thr Ile Lys Lys Gln 
            180                 185                 190         
Met Glu Gln Ala Phe Pro Phe Ile Gln Asp Asn Ser Lys Val Ile Leu 
        195                 200                 205             
Ile Thr Ala His Arg Arg Glu Asn His Gly Glu Gly Ile Lys Asn Ile 
    210                 215                 220                 
Gly Leu Ser Ile Leu Glu Leu Ala Lys Lys Tyr Pro Thr Phe Ser Phe 
225                 230                 235                 240 
Val Ile Pro Leu His Leu Asn Pro Asn Val Arg Lys Pro Ile Gln Asp 
                245                 250                 255     
Leu Leu Ser Ser Val His Asn Val His Leu Ile Glu Pro Gln Glu Tyr 
            260                 265                 270         
Leu Pro Phe Val Tyr Leu Met Ser Lys Ser His Ile Ile Leu Ser Asp 
        275                 280                 285             
Ser Gly Gly Ile Gln Glu Glu Ala Pro Ser Leu Gly Lys Pro Val Leu 
    290                 295                 300                 
Val Leu Arg Asp Thr Thr Glu Arg Pro Glu Ala Val Ala Ala Gly Thr 
305                 310                 315                 320 
Val Lys Leu Val Gly Ser Glu Thr Gln Asn Ile Ile Glu Ser Phe Thr 
                325                 330                 335     
Gln Leu Ile Glu Tyr Pro Glu Tyr Tyr Glu Lys Met Ala Asn Ile Glu 
            340                 345                 350         
Asn Pro Tyr Gly Ile Gly Asn Ala Ser Lys Ile Ile Val Glu Thr Leu 
        355                 360                 365             
Leu Lys Asn Arg 
    370         

<210> 34
<211> 1713
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA StrepII-Thrombin-BamHI/BglII-CsaB-XhoI-His6

<400> 34
atggctagct ggagccaccc gcagttcgaa aaaggcgccc tggttccgcg tggatctttt      60

atacttaata acagaaaatg gcgtaaactt aaaagagacc ctagcgcttt ctttcgagat     120

agtaaattta actttttaag atatttttct gctaaaaaat ttgcaaagaa ttttaaaaat     180

tcatcacata tccataaaac taatataagt aaagctcaat caaatatttc ttcaacctta     240

aaacaaaatc ggaaacaaga tatgttaatt cctattaatt tttttaattt tgaatatata     300

gttaaaaaac ttaacaatca aaacgcaata ggtgtatata ttcttccttc taatcttact     360

cttaagcctg cattatgtat tctagaatca cataaagaag actttttaaa taaatttctt     420

cttactattt cctctgaaaa tttaaagctt caatacaaat ttaatggaca aataaaaaat     480

cctaagtccg taaatgaaat ttggacagat ttatttagca ttgctcatgt tgacatgaaa     540

ctcagcacag atagaacttt aagttcatct atatctcaat tttggttcag attagagttc     600

tgtaaagaag ataaggattt tatcttattt cctacagcta acagatattc tagaaaactt     660

tggaagcact ctattaaaaa taatcaatta tttaaagaag gcatacgaaa ctattcagaa     720

atatcttcat taccctatga agaagatcat aattttgata ttgatttagt atttacttgg     780

gtcaactcag aagataagaa ttggcaagag ttatataaaa aatataagcc cgactttaat     840

agcgatgcaa ccagtacatc aagattcctt agtagagatg aattaaaatt cgcattacgc     900

tcttgggaaa tgaatggatc cttcattcga aaaattttta ttgtctctaa ttgtgctccc     960

ccagcatggc tagatttaaa taaccctaaa attcaatggg tatatcacga agaaattatg    1020

ccacaaagtg cccttcctac ttttagctca catgctattg aaaccagctt gcaccatata    1080

ccaggaatta gtaactattt tatttacagc aatgacgact tcctattaac taaaccattg    1140

aataaagaca atttcttcta ttcgaatggt attgcaaagt taagattaga agcatgggga    1200

aatgttaatg gtgaatgtac tgaaggagaa cctgactact taaatggtgc tcgcaatgcg    1260

aacactctct tagaaaagga atttaaaaaa tttactacta aactacatac tcactcccct    1320

caatccatga gaactgatat tttatttgag atggaaaaaa aatatccaga agagtttaat    1380

agaacactac ataataaatt ccgatcttta gatgatattg cagtaacggg ctatctctat    1440

catcattatg ccctactctc tggacgagca ctacaaagtt ctgacaagac ggaacttgta    1500

cagcaaaatc atgatttcaa aaagaaacta aataatgtag tgaccttaac taaagaaagg    1560

aattttgaca aacttccttt gagcgtatgt atcaacgatg gtgctgatag tcacttgaat    1620

gaagaatgga atgttcaagt tattaagttc ttagaaactc ttttcccatt accatcatca    1680

tttgagaaac tcgagcacca ccaccaccac cac                                 1713


<210> 35
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> DNA StrepII-Thrombin-BamHI/BglII

<400> 35
atggctagct ggagccaccc gcagttcgaa aaaggcgccc tggttccgcg tggatct        57


<210> 36
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> DNA XhoI-His6

<400> 36
ctcgagcacc accaccacca ccac                                           24


<210> 37
<211> 571
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS StrepII-Thrombin-BamHI/BglII-CsaB-XhoI-His6

<400> 37
Met Ala Ser Trp Ser His Pro Gln Phe Glu Lys Gly Ala Leu Val Pro 
1               5                   10                  15      
Arg Gly Ser Phe Ile Leu Asn Asn Arg Lys Trp Arg Lys Leu Lys Arg 
            20                  25                  30          
Asp Pro Ser Ala Phe Phe Arg Asp Ser Lys Phe Asn Phe Leu Arg Tyr 
        35                  40                  45              
Phe Ser Ala Lys Lys Phe Ala Lys Asn Phe Lys Asn Ser Ser His Ile 
    50                  55                  60                  
His Lys Thr Asn Ile Ser Lys Ala Gln Ser Asn Ile Ser Ser Thr Leu 
65                  70                  75                  80  
Lys Gln Asn Arg Lys Gln Asp Met Leu Ile Pro Ile Asn Phe Phe Asn 
                85                  90                  95      
Phe Glu Tyr Ile Val Lys Lys Leu Asn Asn Gln Asn Ala Ile Gly Val 
            100                 105                 110         
Tyr Ile Leu Pro Ser Asn Leu Thr Leu Lys Pro Ala Leu Cys Ile Leu 
        115                 120                 125             
Glu Ser His Lys Glu Asp Phe Leu Asn Lys Phe Leu Leu Thr Ile Ser 
    130                 135                 140                 
Ser Glu Asn Leu Lys Leu Gln Tyr Lys Phe Asn Gly Gln Ile Lys Asn 
145                 150                 155                 160 
Pro Lys Ser Val Asn Glu Ile Trp Thr Asp Leu Phe Ser Ile Ala His 
                165                 170                 175     
Val Asp Met Lys Leu Ser Thr Asp Arg Thr Leu Ser Ser Ser Ile Ser 
            180                 185                 190         
Gln Phe Trp Phe Arg Leu Glu Phe Cys Lys Glu Asp Lys Asp Phe Ile 
        195                 200                 205             
Leu Phe Pro Thr Ala Asn Arg Tyr Ser Arg Lys Leu Trp Lys His Ser 
    210                 215                 220                 
Ile Lys Asn Asn Gln Leu Phe Lys Glu Gly Ile Arg Asn Tyr Ser Glu 
225                 230                 235                 240 
Ile Ser Ser Leu Pro Tyr Glu Glu Asp His Asn Phe Asp Ile Asp Leu 
                245                 250                 255     
Val Phe Thr Trp Val Asn Ser Glu Asp Lys Asn Trp Gln Glu Leu Tyr 
            260                 265                 270         
Lys Lys Tyr Lys Pro Asp Phe Asn Ser Asp Ala Thr Ser Thr Ser Arg 
        275                 280                 285             
Phe Leu Ser Arg Asp Glu Leu Lys Phe Ala Leu Arg Ser Trp Glu Met 
    290                 295                 300                 
Asn Gly Ser Phe Ile Arg Lys Ile Phe Ile Val Ser Asn Cys Ala Pro 
305                 310                 315                 320 
Pro Ala Trp Leu Asp Leu Asn Asn Pro Lys Ile Gln Trp Val Tyr His 
                325                 330                 335     
Glu Glu Ile Met Pro Gln Ser Ala Leu Pro Thr Phe Ser Ser His Ala 
            340                 345                 350         
Ile Glu Thr Ser Leu His His Ile Pro Gly Ile Ser Asn Tyr Phe Ile 
        355                 360                 365             
Tyr Ser Asn Asp Asp Phe Leu Leu Thr Lys Pro Leu Asn Lys Asp Asn 
    370                 375                 380                 
Phe Phe Tyr Ser Asn Gly Ile Ala Lys Leu Arg Leu Glu Ala Trp Gly 
385                 390                 395                 400 
Asn Val Asn Gly Glu Cys Thr Glu Gly Glu Pro Asp Tyr Leu Asn Gly 
                405                 410                 415     
Ala Arg Asn Ala Asn Thr Leu Leu Glu Lys Glu Phe Lys Lys Phe Thr 
            420                 425                 430         
Thr Lys Leu His Thr His Ser Pro Gln Ser Met Arg Thr Asp Ile Leu 
        435                 440                 445             
Phe Glu Met Glu Lys Lys Tyr Pro Glu Glu Phe Asn Arg Thr Leu His 
    450                 455                 460                 
Asn Lys Phe Arg Ser Leu Asp Asp Ile Ala Val Thr Gly Tyr Leu Tyr 
465                 470                 475                 480 
His His Tyr Ala Leu Leu Ser Gly Arg Ala Leu Gln Ser Ser Asp Lys 
                485                 490                 495     
Thr Glu Leu Val Gln Gln Asn His Asp Phe Lys Lys Lys Leu Asn Asn 
            500                 505                 510         
Val Val Thr Leu Thr Lys Glu Arg Asn Phe Asp Lys Leu Pro Leu Ser 
        515                 520                 525             
Val Cys Ile Asn Asp Gly Ala Asp Ser His Leu Asn Glu Glu Trp Asn 
    530                 535                 540                 
Val Gln Val Ile Lys Phe Leu Glu Thr Leu Phe Pro Leu Pro Ser Ser 
545                 550                 555                 560 
Phe Glu Lys Leu Glu His His His His His His 
                565                 570     

<210> 38
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS StrepII-Thrombin-BamHI

<400> 38
Met Ala Ser Trp Ser His Pro Gln Phe Glu Lys Gly Ala Leu Val Pro 
1               5                   10                  15      
Arg Gly Ser 
            

<210> 39
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS XhoI-His6

<400> 39
Leu Glu His His His His His His 
1               5               

<210> 40
<211> 1455
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA NdeI-dN69CsaB(co)-XhoI-His6

<400> 40
catatgctga tcccgatcaa tttctttaat tttgagtaca tcgtgaagaa actgaataac      60

caaaacgcaa tcggcgtgta cattctgccg tctaatctga ccctgaaacc agcattgtgc     120

atcttggagt cgcacaaaga ggacttcctg aacaaatttt tgttgaccat tagcagcgag     180

aacctgaaac tgcagtataa gttcaatggt cagatcaaaa atccgaaaag cgtgaacgaa     240

atctggaccg acctgtttag cattgctcac gtcgacatga agctgagcac cgaccgtacg     300

ctgtcctcgt ccatcagcca attttggttt cgcctggagt tctgtaaaga ggacaaggac     360

ttcatcctgt ttccgacggc aaatcgttac agccgcaagc tgtggaagca cagcatcaaa     420

aataatcagc tgtttaagga aggtatccgt aactacagcg agattagctc gctgccgtac     480

gaggaagacc ataacttcga catcgatctg gtctttacct gggtcaattc ggaagacaaa     540

aactggcagg aactgtacaa gaaatataag ccggatttta atagcgatgc cacctcgacg     600

agccgttttc tgagccgtga cgagctgaag tttgcgctgc gctcgtggga aatgaacggt     660

agcttcatcc gtaaaatctt tatcgtcagc aactgcgcgc cgccggcctg gctggatctg     720

aacaatccga agatccaatg ggtgtatcac gaggagatca tgccacagag cgccctgcca     780

accttcagca gccatgctat tgagactagc ttgcatcaca ttccgggcat ctccaactac     840

ttcatctact ctaatgacga ttttctgttg accaaaccgc tgaacaaaga caacttcttt     900

tactccaacg gtattgctaa actgcgtctg gaagcctggg gtaacgttaa cggtgaatgt     960

accgaaggcg agccggatta cctgaacggc gcgcgtaacg caaatacgct gctggagaaa    1020

gagtttaaaa agtttaccac caagctgcac acccacagcc cgcagagcat gcgtaccgac    1080

atcctgttcg agatggagaa aaaataccca gaagagttca atcgcacgct gcacaacaag    1140

ttccgcagcc tggatgacat cgcggttacc ggctacctgt accatcacta cgcattgctg    1200

tctggccgcg ctctgcaatc cagcgataag accgaactgg tccagcagaa tcacgacttt    1260

aaaaagaagc tgaataatgt tgtcaccctg accaaagagc gtaactttga taagctgccg    1320

ctgagcgttt gtattaatga cggtgcagac agccacctga atgaggagtg gaatgtgcaa    1380

gttatcaaat tcttggagac cttgttcccg ttgccgagct ccttcgagaa actcgagcac    1440

caccaccacc accac                                                     1455


<210> 41
<400> 41
000

<210> 42
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> DNA XhoI-His6

<400> 42
ctcgagcacc accaccacca ccac                                           24


<210> 43
<211> 484
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS NdeI-dN69CsaB(co)-XhoI-His6

<400> 43
Met Leu Ile Pro Ile Asn Phe Phe Asn Phe Glu Tyr Ile Val Lys Lys 
1               5                   10                  15      
Leu Asn Asn Gln Asn Ala Ile Gly Val Tyr Ile Leu Pro Ser Asn Leu 
            20                  25                  30          
Thr Leu Lys Pro Ala Leu Cys Ile Leu Glu Ser His Lys Glu Asp Phe 
        35                  40                  45              
Leu Asn Lys Phe Leu Leu Thr Ile Ser Ser Glu Asn Leu Lys Leu Gln 
    50                  55                  60                  
Tyr Lys Phe Asn Gly Gln Ile Lys Asn Pro Lys Ser Val Asn Glu Ile 
65                  70                  75                  80  
Trp Thr Asp Leu Phe Ser Ile Ala His Val Asp Met Lys Leu Ser Thr 
                85                  90                  95      
Asp Arg Thr Leu Ser Ser Ser Ile Ser Gln Phe Trp Phe Arg Leu Glu 
            100                 105                 110         
Phe Cys Lys Glu Asp Lys Asp Phe Ile Leu Phe Pro Thr Ala Asn Arg 
        115                 120                 125             
Tyr Ser Arg Lys Leu Trp Lys His Ser Ile Lys Asn Asn Gln Leu Phe 
    130                 135                 140                 
Lys Glu Gly Ile Arg Asn Tyr Ser Glu Ile Ser Ser Leu Pro Tyr Glu 
145                 150                 155                 160 
Glu Asp His Asn Phe Asp Ile Asp Leu Val Phe Thr Trp Val Asn Ser 
                165                 170                 175     
Glu Asp Lys Asn Trp Gln Glu Leu Tyr Lys Lys Tyr Lys Pro Asp Phe 
            180                 185                 190         
Asn Ser Asp Ala Thr Ser Thr Ser Arg Phe Leu Ser Arg Asp Glu Leu 
        195                 200                 205             
Lys Phe Ala Leu Arg Ser Trp Glu Met Asn Gly Ser Phe Ile Arg Lys 
    210                 215                 220                 
Ile Phe Ile Val Ser Asn Cys Ala Pro Pro Ala Trp Leu Asp Leu Asn 
225                 230                 235                 240 
Asn Pro Lys Ile Gln Trp Val Tyr His Glu Glu Ile Met Pro Gln Ser 
                245                 250                 255     
Ala Leu Pro Thr Phe Ser Ser His Ala Ile Glu Thr Ser Leu His His 
            260                 265                 270         
Ile Pro Gly Ile Ser Asn Tyr Phe Ile Tyr Ser Asn Asp Asp Phe Leu 
        275                 280                 285             
Leu Thr Lys Pro Leu Asn Lys Asp Asn Phe Phe Tyr Ser Asn Gly Ile 
    290                 295                 300                 
Ala Lys Leu Arg Leu Glu Ala Trp Gly Asn Val Asn Gly Glu Cys Thr 
305                 310                 315                 320 
Glu Gly Glu Pro Asp Tyr Leu Asn Gly Ala Arg Asn Ala Asn Thr Leu 
                325                 330                 335     
Leu Glu Lys Glu Phe Lys Lys Phe Thr Thr Lys Leu His Thr His Ser 
            340                 345                 350         
Pro Gln Ser Met Arg Thr Asp Ile Leu Phe Glu Met Glu Lys Lys Tyr 
        355                 360                 365             
Pro Glu Glu Phe Asn Arg Thr Leu His Asn Lys Phe Arg Ser Leu Asp 
    370                 375                 380                 
Asp Ile Ala Val Thr Gly Tyr Leu Tyr His His Tyr Ala Leu Leu Ser 
385                 390                 395                 400 
Gly Arg Ala Leu Gln Ser Ser Asp Lys Thr Glu Leu Val Gln Gln Asn 
                405                 410                 415     
His Asp Phe Lys Lys Lys Leu Asn Asn Val Val Thr Leu Thr Lys Glu 
            420                 425                 430         
Arg Asn Phe Asp Lys Leu Pro Leu Ser Val Cys Ile Asn Asp Gly Ala 
        435                 440                 445             
Asp Ser His Leu Asn Glu Glu Trp Asn Val Gln Val Ile Lys Phe Leu 
    450                 455                 460                 
Glu Thr Leu Phe Pro Leu Pro Ser Ser Phe Glu Lys Leu Glu His His 
465                 470                 475                 480 
His His His His 
                

<210> 44
<400> 44
000

<210> 45
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> AS XhoI-His6

<400> 45
Leu Glu His His His His His His 
1               5               

<210> 46
<211> 1425
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA deltaN69-CP-A (wt) (1425)

<400> 46
ttaattccta ttaatttttt taattttgaa tatatagtta aaaaacttaa caatcaaaac      60

gcaataggtg tatatattct tccttctaat cttactctta agcctgcatt atgtattcta     120

gaatcacata aagaagactt tttaaataaa tttcttctta ctatttcctc tgaaaattta     180

aagcttcaat acaaatttaa tggacaaata aaaaatccta agtccgtaaa tgaaatttgg     240

acagatttat ttagcattgc tcatgttgac atgaaactca gcacagatag aactttaagt     300

tcatctatat ctcaattttg gttcagatta gagttctgta aagaagataa ggattttatc     360

ttatttccta cagctaacag atattctaga aaactttgga agcactctat taaaaataat     420

caattattta aagaaggcat acgaaactat tcagaaatat cttcattacc ctatgaagaa     480

gatcataatt ttgatattga tttagtattt acttgggtca actcagaaga taagaattgg     540

caagagttat ataaaaaata taagcccgac tttaatagcg atgcaaccag tacatcaaga     600

ttccttagta gagatgaatt aaaattcgca ttacgctctt gggaaatgaa tggatccttc     660

attcgaaaaa tttttattgt ctctaattgt gctcccccag catggctaga tttaaataac     720

cctaaaattc aatgggtata tcacgaagaa attatgccac aaagtgccct tcctactttt     780

agctcacatg ctattgaaac cagcttgcac catataccag gaattagtaa ctattttatt     840

tacagcaatg acgacttcct attaactaaa ccattgaata aagacaattt cttctattcg     900

aatggtattg caaagttaag attagaagca tggggaaatg ttaatggtga atgtactgaa     960

ggagaacctg actacttaaa tggtgctcgc aatgcgaaca ctctcttaga aaaggaattt    1020

aaaaaattta ctactaaact acatactcac tcccctcaat ccatgagaac tgatatttta    1080

tttgagatgg aaaaaaaata tccagaagag tttaatagaa cactacataa taaattccga    1140

tctttagatg atattgcagt aacgggctat ctctatcatc attatgccct actctctgga    1200

cgagcactac aaagttctga caagacggaa cttgtacagc aaaatcatga tttcaaaaag    1260

aaactaaata atgtagtgac cttaactaaa gaaaggaatt ttgacaaact tcctttgagc    1320

gtatgtatca acgatggtgc tgatagtcac ttgaatgaag aatggaatgt tcaagttatt    1380

aagttcttag aaactctttt cccattacca tcatcatttg agaaa                    1425


<210> 47
<211> 2628
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA MBP-S3N10-BamHI-CsxA-Xho1-His6

<400> 47
atgaaaactg aagaaggtaa actggtaatc tggattaacg gcgataaagg ctataacggt      60

ctcgctgaag tcggtaagaa attcgagaaa gataccggaa ttaaagtcac cgttgagcat     120

ccggataaac tggaagagaa attcccacag gttgcggcaa ctggcgatgg ccctgacatt     180

atcttctggg cacacgaccg ctttggtggc tacgctcaat ctggcctgtt ggctgaaatc     240

accccggaca aagcgttcca ggacaagctg tatccgttta cctgggatgc cgtacgttac     300

aacggcaagc tgattgctta cccgatcgct gttgaagcgt tatcgctgat ttataacaaa     360

gatctgctgc cgaacccgcc aaaaacctgg gaagagatcc cggcgctgga taaagaactg     420

aaagcgaaag gtaagagcgc gctgatgttc aacctgcaag aaccgtactt cacctggccg     480

ctgattgctg ctgacggggg ttatgcgttc aagtatgaaa acggcaagta cgacattaaa     540

gacgtgggcg tggataacgc tggcgcgaaa gcgggtctga ccttcctggt tgacctgatt     600

aaaaacaaac acatgaatgc agacaccgat tactccatcg cagaagctgc ctttaataaa     660

ggcgaaacag cgatgaccat caacggcccg tgggcatggt ccaacatcga caccagcaaa     720

gtgaattatg gtgtaacggt actgccgacc ttcaagggtc aaccatccaa accgttcgtt     780

ggcgtgctga gcgcaggtat taacgccgcc agtccgaaca aagagctggc gaaagagttc     840

ctcgaaaact atctgctgac tgatgaaggt ctggaagcgg ttaataaaga caaaccgctg     900

ggtgccgtag cgctgaagtc ttacgaggaa gagttggcga aagatccacg tattgccgcc     960

accatggaaa acgcccagaa aggtgaaatc atgccgaaca tcccgcagat gtccgctttc    1020

tggtatgccg tgcgtactgc ggtgatcaac gccgccagcg gtcgtcagac tgtcgatgaa    1080

gccctgaaag acgcgcagac taattcgagc tccaataaca ataacaacaa caataacaat    1140

aacggatcca ttatgagcaa aattagcaaa ttggtaaccc acccaaacct tttctttcga    1200

gattatttct taaaaaaagc accgttaaat tatggcgaaa atattaaacc tttaccagtc    1260

gaaacctctt ctcatagcaa aaaaaataca gcccataaaa cacccgtatc atccgaccaa    1320

ccaattgaag atccataccc agtaacattt ccaattgatg tagtttatac ttgggtagat    1380

tcagatgatg aaaaattcaa tgaagaacgc ctaaagtttc aaaattcaag cacatctgag    1440

actctacaag gcaaagcaga aagcaccgat attgcaagat tccaatcacg cgacgaatta    1500

aaatattcga ttcgaagcct gatgaagtat gccccatggg taaatcatat ttacattgta    1560

acaaatggtc aaataccaaa atggttagat accaacaata caaaggtaac gattatccct    1620

cactcaacta ttatcgacag tcaatttctc cctactttta attctcacgt cattgaatcc    1680

tctctatata aaatcccagg attatcagag cattacattt atttcaatga tgatgtcatg    1740

ctagctagag atttaagccc atcttatttc tttacaagca gcggattagc aaaactgttt    1800

attaccaact ctcgtctacc aaatggctat aagaatgtga aagacacacc aacccaatgg    1860

gcctcaaaaa attcccgtga gcttttacat gcagaaacag gattttgggc tgaagccatg    1920

tttgcacata cttttcatcc acaacgtaaa agtgtacatg aatctattga acacctatgg    1980

catgaacaat taaatgtttg tcgtcaaaac cgtttccgtg atatttcaga tattaacatg    2040

gcgacattcc tgcaccacca ttttgccatt ttgacaggcc aagctcttgc tacacgcact    2100

aaatgtattt actttaacat tcgctctcct caagcagctc agcattacaa aacattatta    2160

gctcgaaaag gaagcgaata cagcccacat tctatctgct taaatgatca tacatcgagc    2220

aataaaaata ttttatctaa ttacgaagcc aaattacaaa gctttttaga aacatactat    2280

ccagatgtat cagaagcaga aattctcctt cctactaaat ctgaagtagc tgaattagtt    2340

aaacataaag attatttaac tgtatatact aaattattac ctattatcaa taagcagctg    2400

gtcaataaat ataataaacc ttattcatat cttttctatt atttaggttt atctgcccgg    2460

tttttatttg aagaaacgca acaagaacac taccgggaaa ctgctgaaga aaatttacaa    2520

atcttttgtg gcctaaaccc aaaacataca ctagccctca aatacttagc ggatgtcacc    2580

ctcacatcac agcctagtgg acaactcgag caccaccacc accaccac                 2628


<210> 48
<211> 1149
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA MBP-S3N10-BamHI

<400> 48
atgaaaactg aagaaggtaa actggtaatc tggattaacg gcgataaagg ctataacggt      60

ctcgctgaag tcggtaagaa attcgagaaa gataccggaa ttaaagtcac cgttgagcat     120

ccggataaac tggaagagaa attcccacag gttgcggcaa ctggcgatgg ccctgacatt     180

atcttctggg cacacgaccg ctttggtggc tacgctcaat ctggcctgtt ggctgaaatc     240

accccggaca aagcgttcca ggacaagctg tatccgttta cctgggatgc cgtacgttac     300

aacggcaagc tgattgctta cccgatcgct gttgaagcgt tatcgctgat ttataacaaa     360

gatctgctgc cgaacccgcc aaaaacctgg gaagagatcc cggcgctgga taaagaactg     420

aaagcgaaag gtaagagcgc gctgatgttc aacctgcaag aaccgtactt cacctggccg     480

ctgattgctg ctgacggggg ttatgcgttc aagtatgaaa acggcaagta cgacattaaa     540

gacgtgggcg tggataacgc tggcgcgaaa gcgggtctga ccttcctggt tgacctgatt     600

aaaaacaaac acatgaatgc agacaccgat tactccatcg cagaagctgc ctttaataaa     660

ggcgaaacag cgatgaccat caacggcccg tgggcatggt ccaacatcga caccagcaaa     720

gtgaattatg gtgtaacggt actgccgacc ttcaagggtc aaccatccaa accgttcgtt     780

ggcgtgctga gcgcaggtat taacgccgcc agtccgaaca aagagctggc gaaagagttc     840

ctcgaaaact atctgctgac tgatgaaggt ctggaagcgg ttaataaaga caaaccgctg     900

ggtgccgtag cgctgaagtc ttacgaggaa gagttggcga aagatccacg tattgccgcc     960

accatggaaa acgcccagaa aggtgaaatc atgccgaaca tcccgcagat gtccgctttc    1020

tggtatgccg tgcgtactgc ggtgatcaac gccgccagcg gtcgtcagac tgtcgatgaa    1080

gccctgaaag acgcgcagac taattcgagc tccaataaca ataacaacaa caataacaat    1140

aacggatcc                                                            1149


<210> 49
<211> 876
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS MBP-S3N10-BamHI-CsxA-Xho1-His6

<400> 49
Met Lys Thr Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      
Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          
Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              
Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  
His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  
Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      
Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         
Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             
Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 
Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 
Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     
Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         
Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             
Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 
Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 
Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     
Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         
Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             
Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 
Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 
Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     
Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         
Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             
Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Gly Ser Ile 
    370                 375                 380                 
Met Ser Lys Ile Ser Lys Leu Val Thr His Pro Asn Leu Phe Phe Arg 
385                 390                 395                 400 
Asp Tyr Phe Leu Lys Lys Ala Pro Leu Asn Tyr Gly Glu Asn Ile Lys 
                405                 410                 415     
Pro Leu Pro Val Glu Thr Ser Ser His Ser Lys Lys Asn Thr Ala His 
            420                 425                 430         
Lys Thr Pro Val Ser Ser Asp Gln Pro Ile Glu Asp Pro Tyr Pro Val 
        435                 440                 445             
Thr Phe Pro Ile Asp Val Val Tyr Thr Trp Val Asp Ser Asp Asp Glu 
    450                 455                 460                 
Lys Phe Asn Glu Glu Arg Leu Lys Phe Gln Asn Ser Ser Thr Ser Glu 
465                 470                 475                 480 
Thr Leu Gln Gly Lys Ala Glu Ser Thr Asp Ile Ala Arg Phe Gln Ser 
                485                 490                 495     
Arg Asp Glu Leu Lys Tyr Ser Ile Arg Ser Leu Met Lys Tyr Ala Pro 
            500                 505                 510         
Trp Val Asn His Ile Tyr Ile Val Thr Asn Gly Gln Ile Pro Lys Trp 
        515                 520                 525             
Leu Asp Thr Asn Asn Thr Lys Val Thr Ile Ile Pro His Ser Thr Ile 
    530                 535                 540                 
Ile Asp Ser Gln Phe Leu Pro Thr Phe Asn Ser His Val Ile Glu Ser 
545                 550                 555                 560 
Ser Leu Tyr Lys Ile Pro Gly Leu Ser Glu His Tyr Ile Tyr Phe Asn 
                565                 570                 575     
Asp Asp Val Met Leu Ala Arg Asp Leu Ser Pro Ser Tyr Phe Phe Thr 
            580                 585                 590         
Ser Ser Gly Leu Ala Lys Leu Phe Ile Thr Asn Ser Arg Leu Pro Asn 
        595                 600                 605             
Gly Tyr Lys Asn Val Lys Asp Thr Pro Thr Gln Trp Ala Ser Lys Asn 
    610                 615                 620                 
Ser Arg Glu Leu Leu His Ala Glu Thr Gly Phe Trp Ala Glu Ala Met 
625                 630                 635                 640 
Phe Ala His Thr Phe His Pro Gln Arg Lys Ser Val His Glu Ser Ile 
                645                 650                 655     
Glu His Leu Trp His Glu Gln Leu Asn Val Cys Arg Gln Asn Arg Phe 
            660                 665                 670         
Arg Asp Ile Ser Asp Ile Asn Met Ala Thr Phe Leu His His His Phe 
        675                 680                 685             
Ala Ile Leu Thr Gly Gln Ala Leu Ala Thr Arg Thr Lys Cys Ile Tyr 
    690                 695                 700                 
Phe Asn Ile Arg Ser Pro Gln Ala Ala Gln His Tyr Lys Thr Leu Leu 
705                 710                 715                 720 
Ala Arg Lys Gly Ser Glu Tyr Ser Pro His Ser Ile Cys Leu Asn Asp 
                725                 730                 735     
His Thr Ser Ser Asn Lys Asn Ile Leu Ser Asn Tyr Glu Ala Lys Leu 
            740                 745                 750         
Gln Ser Phe Leu Glu Thr Tyr Tyr Pro Asp Val Ser Glu Ala Glu Ile 
        755                 760                 765             
Leu Leu Pro Thr Lys Ser Glu Val Ala Glu Leu Val Lys His Lys Asp 
    770                 775                 780                 
Tyr Leu Thr Val Tyr Thr Lys Leu Leu Pro Ile Ile Asn Lys Gln Leu 
785                 790                 795                 800 
Val Asn Lys Tyr Asn Lys Pro Tyr Ser Tyr Leu Phe Tyr Tyr Leu Gly 
                805                 810                 815     
Leu Ser Ala Arg Phe Leu Phe Glu Glu Thr Gln Gln Glu His Tyr Arg 
            820                 825                 830         
Glu Thr Ala Glu Glu Asn Leu Gln Ile Phe Cys Gly Leu Asn Pro Lys 
        835                 840                 845             
His Thr Leu Ala Leu Lys Tyr Leu Ala Asp Val Thr Leu Thr Ser Gln 
    850                 855                 860                 
Pro Ser Gly Gln Leu Glu His His His His His His 
865                 870                 875     

<210> 50
<211> 383
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS MBP-S3N10-BamHI

<400> 50
Met Lys Thr Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      
Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          
Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              
Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  
His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  
Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      
Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         
Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             
Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 
Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 
Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     
Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         
Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             
Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 
Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 
Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     
Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         
Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             
Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 
Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 
Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     
Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         
Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             
Ser Ser Ser Asn Asn Asn Asn Asn Asn Asn Asn Asn Asn Gly Ser 
    370                 375                 380             

<210> 51
<211> 1263
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA NdeI-dN65dC10-CsxA-XhoI-His6

<400> 51
catatggtaa catttccaat tgatgtagtt tatacttggg tagattcaga tgatgaaaaa      60

ttcaatgaag aacgcctaaa gtttcaaaat tcaagcacat ctgagactct acaaggcaaa     120

gcagaaagca ccgatattgc aagattccaa tcacgcgacg aattaaaata ttcgattcga     180

agcctgatga agtatgcccc atgggtaaat catatttaca ttgtaacaaa tggtcaaata     240

ccaaaatggt tagataccaa caatacaaag gtaacgatta tccctcactc aactattatc     300

gacagtcaat ttctccctac ttttaattct cacgtcattg aatcctctct atataaaatc     360

ccaggattat cagagcatta catttatttc aatgatgatg tcatgctagc tagagattta     420

agcccatctt atttctttac aagcagcgga ttagcaaaac tgtttattac caactctcgt     480

ctaccaaatg gctataagaa tgtgaaagac acaccaaccc aatgggcctc aaaaaattcc     540

cgtgagcttt tacatgcaga aacaggattt tgggctgaag ccatgtttgc acatactttt     600

catccacaac gtaaaagtgt acatgaatct attgaacacc tatggcatga acaattaaat     660

gtttgtcgtc aaaaccgttt ccgtgatatt tcagatatta acatggcgac attcctgcac     720

caccattttg ccattttgac aggccaagct cttgctacac gcactaaatg tatttacttt     780

aacattcgct ctcctcaagc agctcagcat tacaaaacat tattagctcg aaaaggaagc     840

gaatacagcc cacattctat ctgcttaaat gatcatacat cgagcaataa aaatatttta     900

tctaattacg aagccaaatt acaaagcttt ttagaaacat actatccaga tgtatcagaa     960

gcagaaattc tccttcctac taaatctgaa gtagctgaat tagttaaaca taaagattat    1020

ttaactgtat atactaaatt attacctatt atcaataagc agctggtcaa taaatataat    1080

aaaccttatt catatctttt ctattattta ggtttatctg cccggttttt atttgaagaa    1140

acgcaacaag aacactaccg ggaaactgct gaagaaaatt tacaaatctt ttgtggccta    1200

aacccaaaac atacactagc cctcaaatac ttagcggatc tcgagcacca ccaccaccac    1260

cac                                                                  1263


<210> 52
<211> 420
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS NdeI-dN65dC10-CsxA-XhoI-His6

<400> 52
Met Val Thr Phe Pro Ile Asp Val Val Tyr Thr Trp Val Asp Ser Asp 
1               5                   10                  15      
Asp Glu Lys Phe Asn Glu Glu Arg Leu Lys Phe Gln Asn Ser Ser Thr 
            20                  25                  30          
Ser Glu Thr Leu Gln Gly Lys Ala Glu Ser Thr Asp Ile Ala Arg Phe 
        35                  40                  45              
Gln Ser Arg Asp Glu Leu Lys Tyr Ser Ile Arg Ser Leu Met Lys Tyr 
    50                  55                  60                  
Ala Pro Trp Val Asn His Ile Tyr Ile Val Thr Asn Gly Gln Ile Pro 
65                  70                  75                  80  
Lys Trp Leu Asp Thr Asn Asn Thr Lys Val Thr Ile Ile Pro His Ser 
                85                  90                  95      
Thr Ile Ile Asp Ser Gln Phe Leu Pro Thr Phe Asn Ser His Val Ile 
            100                 105                 110         
Glu Ser Ser Leu Tyr Lys Ile Pro Gly Leu Ser Glu His Tyr Ile Tyr 
        115                 120                 125             
Phe Asn Asp Asp Val Met Leu Ala Arg Asp Leu Ser Pro Ser Tyr Phe 
    130                 135                 140                 
Phe Thr Ser Ser Gly Leu Ala Lys Leu Phe Ile Thr Asn Ser Arg Leu 
145                 150                 155                 160 
Pro Asn Gly Tyr Lys Asn Val Lys Asp Thr Pro Thr Gln Trp Ala Ser 
                165                 170                 175     
Lys Asn Ser Arg Glu Leu Leu His Ala Glu Thr Gly Phe Trp Ala Glu 
            180                 185                 190         
Ala Met Phe Ala His Thr Phe His Pro Gln Arg Lys Ser Val His Glu 
        195                 200                 205             
Ser Ile Glu His Leu Trp His Glu Gln Leu Asn Val Cys Arg Gln Asn 
    210                 215                 220                 
Arg Phe Arg Asp Ile Ser Asp Ile Asn Met Ala Thr Phe Leu His His 
225                 230                 235                 240 
His Phe Ala Ile Leu Thr Gly Gln Ala Leu Ala Thr Arg Thr Lys Cys 
                245                 250                 255     
Ile Tyr Phe Asn Ile Arg Ser Pro Gln Ala Ala Gln His Tyr Lys Thr 
            260                 265                 270         
Leu Leu Ala Arg Lys Gly Ser Glu Tyr Ser Pro His Ser Ile Cys Leu 
        275                 280                 285             
Asn Asp His Thr Ser Ser Asn Lys Asn Ile Leu Ser Asn Tyr Glu Ala 
    290                 295                 300                 
Lys Leu Gln Ser Phe Leu Glu Thr Tyr Tyr Pro Asp Val Ser Glu Ala 
305                 310                 315                 320 
Glu Ile Leu Leu Pro Thr Lys Ser Glu Val Ala Glu Leu Val Lys His 
                325                 330                 335     
Lys Asp Tyr Leu Thr Val Tyr Thr Lys Leu Leu Pro Ile Ile Asn Lys 
            340                 345                 350         
Gln Leu Val Asn Lys Tyr Asn Lys Pro Tyr Ser Tyr Leu Phe Tyr Tyr 
        355                 360                 365             
Leu Gly Leu Ser Ala Arg Phe Leu Phe Glu Glu Thr Gln Gln Glu His 
    370                 375                 380                 
Tyr Arg Glu Thr Ala Glu Glu Asn Leu Gln Ile Phe Cys Gly Leu Asn 
385                 390                 395                 400 
Pro Lys His Thr Leu Ala Leu Lys Tyr Leu Ala Asp Leu Glu His His 
                405                 410                 415     
His His His His 
            420 

<210> 53
<211> 741
<212> DNA
<213> Neisseria meningitidis

<220> 
<223> DNA CsaC

<400> 53
atgttatcta atttaaaaac aggaaataat atcttaggat tacctgaatt tgagttgaat      60

ggctgccgat tcttatataa aaaaggtata gaaaaaacaa ttattacttt ttcagcattt     120

cctcctaaag atattgctca aaaatataat tatataaaag attttttaag ttctaattat     180

acttttttag cattcttaga taccaaatat ccagaagatg atgctagagg cacttattac     240

attactaatg agttagataa tggatattta caaaccatac attgtattat tcaattatta     300

tcgaatacaa atcaagaaga tacctacctt ttgggttcaa gtaaaggtgg cgttggcgca     360

cttctactcg gtcttacata taattatcct aatataatta ttaatgctcc tcaagccaaa     420

ttagcagatt atatcaaaac acgctcgaaa accattcttt catatatgct tggaacctct     480

aaaagatttc aagatattaa ttacgattat atcaatgact tcttactatc taaaattaag     540

acttgcgact cctcacttaa atggaatatt catataactt gcggaaaaga tgattcatat     600

catttaaatg aattagaaat tctaaaaaat gaatttaata taaaagctat tacgattaaa     660

accaaactaa tttctggcgg gcatgataat gaagcaattg cccactatag agaatacttt     720

aaaaccataa tccaaaatat a                                               741


<210> 54
<211> 247
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> AS CsaC

<400> 54
Met Leu Ser Asn Leu Lys Thr Gly Asn Asn Ile Leu Gly Leu Pro Glu 
1               5                   10                  15      
Phe Glu Leu Asn Gly Cys Arg Phe Leu Tyr Lys Lys Gly Ile Glu Lys 
            20                  25                  30          
Thr Ile Ile Thr Phe Ser Ala Phe Pro Pro Lys Asp Ile Ala Gln Lys 
        35                  40                  45              
Tyr Asn Tyr Ile Lys Asp Phe Leu Ser Ser Asn Tyr Thr Phe Leu Ala 
    50                  55                  60                  
Phe Leu Asp Thr Lys Tyr Pro Glu Asp Asp Ala Arg Gly Thr Tyr Tyr 
65                  70                  75                  80  
Ile Thr Asn Glu Leu Asp Asn Gly Tyr Leu Gln Thr Ile His Cys Ile 
                85                  90                  95      
Ile Gln Leu Leu Ser Asn Thr Asn Gln Glu Asp Thr Tyr Leu Leu Gly 
            100                 105                 110         
Ser Ser Lys Gly Gly Val Gly Ala Leu Leu Leu Gly Leu Thr Tyr Asn 
        115                 120                 125             
Tyr Pro Asn Ile Ile Ile Asn Ala Pro Gln Ala Lys Leu Ala Asp Tyr 
    130                 135                 140                 
Ile Lys Thr Arg Ser Lys Thr Ile Leu Ser Tyr Met Leu Gly Thr Ser 
145                 150                 155                 160 
Lys Arg Phe Gln Asp Ile Asn Tyr Asp Tyr Ile Asn Asp Phe Leu Leu 
                165                 170                 175     
Ser Lys Ile Lys Thr Cys Asp Ser Ser Leu Lys Trp Asn Ile His Ile 
            180                 185                 190         
Thr Cys Gly Lys Asp Asp Ser Tyr His Leu Asn Glu Leu Glu Ile Leu 
        195                 200                 205             
Lys Asn Glu Phe Asn Ile Lys Ala Ile Thr Ile Lys Thr Lys Leu Ile 
    210                 215                 220                 
Ser Gly Gly His Asp Asn Glu Ala Ile Ala His Tyr Arg Glu Tyr Phe 
225                 230                 235                 240 
Lys Thr Ile Ile Gln Asn Ile 
                245         

<210> 55
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer KS422/KS273

<400> 55
gcatctcata tggctgttat tatatttgtt aacg                                 34


<210> 56
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer wt NmW-135

<400> 56
ccgctcgagt ttttcttggc caaaaaactg                                     30


<210> 57
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer wt NmY

<400> 57
ccgctcgagt ttttcttggc caaaaaactg                                     30


<210> 58
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer KS350/KS351

<400> 58
ctgatcatga catcagaaag tgcgggattt ccatatatat ttatg                     45


<210> 59
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer E307A

<400> 59
cataaatata tatggaaatc ccgcactttc tgatgtcatg atcag                     45


<210> 60
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer KS370/KS371

<400> 60
atctcgcgtt gctgtaggtg tttatgcaac tagcttattt g                         41


<210> 61
<211> 41
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer S972A

<400> 61
caaataagct agttgcataa acacctacag caacgcgaga t                         41


<210> 62
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer AR11/AR12

<400> 62
atacagatat cctaatcatg acatctcaaa gcgcaggctt tggttatata t              51


<210> 63
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer E307A

<400> 63
atatataacc aaagcctgcg ctttgagatg tcatgattag gatatctgta t              51


<210> 64
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer KS422/KS421

<400> 64
gcatctcata tggctgttat tatatttgtt aacg                                 34


<210> 65
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer C-delta639

<400> 65
ccgctcgagg ctgcgcggaa gaatagtg                                       28


<210> 66
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer AR2/KS273

<400> 66
gcatctcata tgtttaataa cgtatcatta tcgtc                                35


<210> 67
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer N-delta398

<400> 67
ccgctcgagt ttttcttggc caaaaaactg                                     30


<210> 68
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer AR1/KS273

<400> 68
gcatctcata tgactgatga taatttaata cctat                                35


<210> 69
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer N-delta562

<400> 69
ccgctcgagt ttttcttggc caaaaaactg                                     30


<210> 70
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer AR9/AR273

<400> 70
gcatctcata tgaaatattc ttataaatat atcta                                35


<210> 71
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer N-delta609

<400> 71
ccgctcgagt ttttcttggc caaaaaactg                                     30


<210> 72
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer AR10/KS273

<400> 72
gcatctcata tgtcttggga acttattcgt gcctc                                35


<210> 73
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer N-delta639

<400> 73
ccgctcgagt ttttcttggc caaaaaactg                                     30


<210> 74
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer KS433/KS273

<400> 74
gcatctcata tgggtaagcg ttcgatggat g                                   31


<210> 75
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer N-delta676

<400> 75
ccgctcgagt ttttcttggc caaaaaactg                                     30


<210> 76
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer KS434/KS273

<400> 76
gcatctcata tgtcactgaa aagtaatgta gttg                                 34


<210> 77
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer N-delta729

<400> 77
ccgctcgagt ttttcttggc caaaaaactg                                     30


<210> 78
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer KS435/KS273

<400> 78
gcatctcata tgaatatcga agcatttcta aaacc                                35


<210> 79
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer N-delta777

<400> 79
ccgctcgagt ttttcttggc caaaaaactg                                     30


<210> 80
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer KS422/KS421

<400> 80
gcatctcata tggctgttat tatatttgtt aacg                                 34


<210> 81
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer C-delta639

<400> 81
ccgctcgagg ctgcgcggaa gaatagtg                                       28


<210> 82
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer KS422/KS374

<400> 82
gcatctcata tggctgttat tatatttgtt aacg                                 34


<210> 83
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer C-delta479

<400> 83
ccgctcgagc gtttgcatgt tgggtaaag                                      29


<210> 84
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer AR2/KS273

<400> 84
gcatctcata tgtttaataa cgtatcatta tcgtc                                35


<210> 85
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer N-delta398

<400> 85
ccgctcgagt ttttcttggc caaaaaactg                                     30


<210> 86
<211> 35
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer AR1/KS273

<400> 86
gcatctcata tgactgatga taatttaata cctat                                35


<210> 87
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer N-delta562

<400> 87
ccgctcgagt ttttcttggc caaaaaactg                                     30


<210> 88
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer KS433/KS273

<400> 88
gcatctcata tgggtaagcg ttcgatggat g                                   31


<210> 89
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer N-delta 676

<400> 89
ccgctcgagt ttttcttggc caaaaaactg                                     30


<210> 90
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer KS434/KS273

<400> 90
gcatctcata tgtcactgaa aagtaatgta gttg                                 34


<210> 91
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> N-delta 729

<400> 91
ccgctcgagt ttttcttggc caaaaaactg                                     30


<210> 92
<211> 31
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recloning primer

<400> 92
gcatctcata tgggtaagcg ttcgatggat g                                   31


<210> 93
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Recloning Primer

<400> 93
ccgctcgagt ttttcttggc caaaaaactg                                     30


<210> 94
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-CsaA-His6

<400> 94
gcggatccaa agtcttaacc gtctttggc                                      29


<210> 95
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-CsaA-His6

<400> 95
ccgctcgagt ctattcttta ataaagtttc taca                                 34


<210> 96
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-CsaB-His6

<400> 96
gcagatcttt tatacttaat aacagaaaat ggc                                  33


<210> 97
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-CsaB-His6

<400> 97
ccgctcgagt ttctcaaatg atgatggtaa tg                                   32


<210> 98
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-delta69-CsaB-His6

<400> 98
ccgctcgagt ttctcaaatg atgatggtaa tg                                   32


<210> 99
<211> 34
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-delta69-CsaB-His6

<400> 99
gcagatctat gttaattcct attaattttt ttaa                                 34


<210> 100
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer delta69-CsaB-His6

<400> 100
ccgctcgagt ttctcaaatg atgatggtaa tg                                   32


<210> 101
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer delta69-CsaB-His6

<400> 101
gcatctcata tgttaattcc tattaatttt ttttaattt                            39


<210> 102
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer delta69-CsaBCo-His6

<400> 102
gcatctcata tgctgatccc gatcaatttc ttt                                  33


<210> 103
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer delta69-CsaBCo-His6

<400> 103
ccgctcgagt ttctcgaagg agctcggc                                       28


<210> 104
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-CsaC-His6

<400> 104
ccgctcgagt atattttgga ttatggt                                        27


<210> 105
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-CsaC-His6

<400> 105
gcggatcctt atctaattta aaaacagg                                       28


<210> 106
<211> 366
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> NmL (CsIA); Homologue of CsxA/CsaB

<400> 106
Met Lys Arg Leu Lys Lys Leu Thr Arg Glu Pro Gly Val Phe Phe Arg 
1               5                   10                  15      
Asp Tyr Phe Asn Lys Lys Tyr Pro Val Arg Asn Ile Glu Gln Arg Ile 
            20                  25                  30          
Asn Glu Ile Glu Glu Pro Ala Ile Ile Ala Asn Ser Leu His Leu Ala 
        35                  40                  45              
Ala Val Glu Ser Ala Ile His Leu Ser Pro Phe Lys Ile Asp Val Val 
    50                  55                  60                  
Phe Thr Trp Val Asp Asn Ser Asp Thr Gln Trp Gln Gln Arg His Gln 
65                  70                  75                  80  
Gln Tyr Cys His Ala Ala Ser Pro Asn Asn Leu Tyr Ser Asn Asp Glu 
                85                  90                  95      
Thr Arg Phe Ala Asn His Asn Glu Leu Tyr Tyr Ser Leu His Ser Val 
            100                 105                 110         
Arg Ser Phe Leu Pro Trp Val Asn His Ile Tyr Ile Ile Thr Asp Ser 
        115                 120                 125             
Gln Thr Pro Lys Trp Phe Lys Ser Ala Glu Tyr Pro Asn Val Ser Ile 
    130                 135                 140                 
Ile Asp His Ser Glu Ile Ile Asp Lys Gln Tyr Leu Pro Thr Phe Asn 
145                 150                 155                 160 
Ser His Val Ile Glu Ala His Leu His Asn Ile Pro Asn Leu Ser Glu 
                165                 170                 175     
His Phe Ile Tyr Phe Asn Asp Asp Val Phe Val Ala Arg Pro Leu His 
            180                 185                 190         
Arg Glu His Phe Phe His Ala Asn Gly Ile Ala Ser Leu Phe Ile Ala 
        195                 200                 205             
Asp Lys Ser Leu Gln Lys Met Ala Thr Lys Gly Thr Ile Thr Pro Thr 
    210                 215                 220                 
Leu Ser Ala Ser Gln Asn Cys Ile Arg Leu Leu Asn Gln Arg Tyr Asp 
225                 230                 235                 240 
Cys Asn Leu Asp His Pro Leu Val His Thr Tyr Val Pro Leu Arg Lys 
                245                 250                 255     
Ser Gly Phe Gln Thr Ala Trp Gln Tyr Tyr Arg Glu Glu Ile Lys Ala 
            260                 265                 270         
Phe Leu Pro Asn Lys Phe Arg Thr Asn Gln Asp Leu Asn Leu Ala Thr 
        275                 280                 285             
Phe Leu Val Pro Trp Leu Met Tyr Leu Asp Gly Lys Ser Ile Pro Asn 
    290                 295                 300                 
Asn Asp Ile Cys Tyr Tyr Phe Asn Ile Arg Ser Asn Lys Ala Pro Thr 
305                 310                 315                 320 
Gln Tyr Leu Lys Leu Leu Gln Lys Asn Glu Asp Asn Gln Gln Pro His 
                325                 330                 335     
Ser Phe Cys Ala Asn Asp Phe His Ser Glu Gln Gln Leu Tyr Asp Tyr 
            340                 345                 350         
His Ala Lys Leu Ile Ala Met Leu Lys Asp Tyr Phe Lys Ile 
        355                 360                 365     

<210> 107
<211> 1037
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> polymerase of serogroup Y

<400> 107
Met Ala Val Ile Ile Phe Val Asn Gly Ile Arg Ala Val Asn Gly Leu 
1               5                   10                  15      
Val Lys Ser Ser Ile Asn Thr Ala Asn Ala Phe Ala Glu Glu Gly Leu 
            20                  25                  30          
Asp Val His Leu Ile Asn Phe Val Gly Asn Ile Thr Gly Ala Glu His 
        35                  40                  45              
Leu Ser Pro Pro Phe His Leu His Pro Asn Val Lys Thr Ser Ser Ile 
    50                  55                  60                  
Ile Asp Leu Phe Asn Asp Ile Pro Glu Asn Val Ser Cys Arg Asn Ile 
65                  70                  75                  80  
Pro Phe Tyr Ser Ile His Gln Gln Phe Phe Lys Ala Glu Tyr Ser Ala 
                85                  90                  95      
His Tyr Lys His Val Leu Met Lys Ile Glu Ser Leu Leu Ser Glu Glu 
            100                 105                 110         
Asp Ser Ile Ile Phe Thr His Pro Leu Gln Leu Glu Met Tyr Arg Leu 
        115                 120                 125             
Ala Asn Asn Asn Ile Lys Ser Lys Ala Lys Leu Ile Val Gln Ile His 
    130                 135                 140                 
Gly Asn Tyr Met Glu Glu Ile His Asn Tyr Glu Ile Trp Ala Arg Asn 
145                 150                 155                 160 
Ile Asp Tyr Val Asp Tyr Leu Gln Thr Val Ser Asp Glu Met Leu Glu 
                165                 170                 175     
Glu Met His Ser His Phe Lys Ile Lys Lys Asp Lys Leu Val Phe Ile 
            180                 185                 190         
Pro Asn Ile Thr Tyr Pro Ile Ser Leu Glu Lys Lys Glu Ala Asp Phe 
        195                 200                 205             
Phe Ile Lys Asp Asn Glu Asp Ile Asp Asn Ala Gln Lys Phe Lys Arg 
    210                 215                 220                 
Ile Ser Ile Val Gly Ser Ile Gln Pro Arg Lys Asn Gln Leu Asp Ala 
225                 230                 235                 240 
Ile Lys Ile Ile Asn Lys Ile Lys Asn Glu Asn Tyr Ile Leu Gln Ile 
                245                 250                 255     
Tyr Gly Lys Ser Ile Asn Lys Asp Tyr Phe Glu Leu Ile Lys Lys Tyr 
            260                 265                 270         
Ile Lys Asp Asn Lys Leu Gln Asn Arg Ile Leu Phe Lys Gly Glu Ser 
        275                 280                 285             
Ser Glu Gln Glu Ile Tyr Glu Asn Thr Asp Ile Leu Ile Met Thr Ser 
    290                 295                 300                 
Gln Ser Glu Gly Phe Gly Tyr Ile Phe Leu Glu Gly Met Val Tyr Asp 
305                 310                 315                 320 
Ile Pro Ile Leu Ala Tyr Asn Phe Lys Tyr Gly Ala Asn Asp Phe Ser 
                325                 330                 335     
Asn Tyr Asn Glu Asn Ala Ser Val Phe Lys Thr Gly Asp Ile Ser Gly 
            340                 345                 350         
Met Ala Lys Lys Ile Ile Glu Leu Leu Asn Asn Pro Glu Lys Tyr Lys 
        355                 360                 365             
Glu Leu Val Gln Tyr Asn His Asn Arg Phe Leu Lys Glu Tyr Ala Lys 
    370                 375                 380                 
Asp Val Val Met Ala Lys Tyr Phe Thr Ile Leu Pro Arg Ser Phe Asn 
385                 390                 395                 400 
Asn Val Ser Leu Ser Ser Ala Phe Ser Arg Lys Glu Leu Asp Glu Phe 
                405                 410                 415     
Gln Asn Ile Thr Phe Ser Ile Glu Asp Ser Asn Asp Leu Ala His Ile 
            420                 425                 430         
Trp Asn Phe Glu Leu Thr Asn Pro Ala Gln Asn Met Asn Phe Phe Ala 
        435                 440                 445             
Leu Val Gly Lys Arg Lys Phe Pro Met Asp Ala His Ile Gln Gly Thr 
    450                 455                 460                 
Gln Cys Thr Ile Lys Ile Ala His Lys Lys Thr Gly Asn Leu Leu Ser 
465                 470                 475                 480 
Leu Leu Leu Lys Lys Arg Asn Gln Leu Asn Leu Ser Arg Gly Tyr Thr 
                485                 490                 495     
Leu Ile Ala Glu Asp Asn Ser Tyr Glu Lys Tyr Ile Gly Ala Ile Ser 
            500                 505                 510         
Asn Lys Gly Asn Phe Glu Ile Ile Ala Asn Lys Lys Asn Ser Leu Val 
        515                 520                 525             
Thr Ile Asn Lys Ser Thr Leu Glu Leu His Glu Ile Pro His Glu Leu 
    530                 535                 540                 
His Gln Asn Lys Leu Leu Ile Ala Leu Pro Asn Met Gln Thr Pro Leu 
545                 550                 555                 560 
Lys Ile Thr Asp Asp Asn Leu Ile Pro Ile Gln Ala Ser Ile Lys Leu 
                565                 570                 575     
Glu Lys Ile Gly Asn Thr Tyr Tyr Pro Cys Phe Leu Pro Ser Gly Ile 
            580                 585                 590         
Phe Asn Asn Ile Cys Leu Asp Tyr Gly Glu Glu Ser Lys Ile Ile Asn 
        595                 600                 605             
Phe Ser Lys Tyr Ser Tyr Lys Tyr Ile Tyr Asp Ser Ile Arg His Ile 
    610                 615                 620                 
Glu Gln His Thr Asp Ile Ser Asp Ile Ile Val Cys Asn Val Tyr Ser 
625                 630                 635                 640 
Trp Glu Leu Ile Arg Ala Ser Val Ile Glu Ser Leu Met Glu Phe Thr 
                645                 650                 655     
Gly Lys Trp Glu Lys His Phe Gln Thr Ser Pro Lys Ile Asp Tyr Arg 
            660                 665                 670         
Phe Asp His Glu Gly Lys Arg Ser Met Asp Asp Val Phe Ser Glu Glu 
        675                 680                 685             
Thr Phe Ile Met Glu Phe Pro Arg Lys Asn Gly Ile Asp Lys Lys Thr 
    690                 695                 700                 
Ala Ala Phe Gln Asn Ile Pro Asn Ser Ile Val Met Glu Tyr Pro Gln 
705                 710                 715                 720 
Thr Asn Gly Tyr Ser Met Arg Ser His Ser Leu Lys Ser Asn Val Val 
                725                 730                 735     
Ala Ala Lys His Phe Leu Glu Lys Leu Asn Lys Ile Lys Val Asp Ile 
            740                 745                 750         
Lys Phe Lys Lys His Asp Leu Ala Asn Ile Lys Lys Met Asn Arg Ile 
        755                 760                 765             
Ile Tyr Glu His Leu Gly Ile Asn Ile Asn Ile Glu Ala Phe Leu Lys 
    770                 775                 780                 
Pro Arg Leu Glu Lys Phe Lys Arg Glu Glu Lys Tyr Phe His Asp Phe 
785                 790                 795                 800 
Phe Lys Arg Asn Asn Phe Lys Glu Val Ile Phe Pro Ser Thr Tyr Trp 
                805                 810                 815     
Asn Pro Gly Ile Ile Cys Ala Ala His Lys Gln Gly Ile Lys Val Ser 
            820                 825                 830         
Asp Ile Gln Tyr Ala Ala Ile Thr Pro Tyr His Pro Ala Tyr Phe Lys 
        835                 840                 845             
Ser Pro Lys Ser His Tyr Val Ala Asp Lys Leu Phe Leu Trp Ser Glu 
    850                 855                 860                 
Tyr Trp Asn His Glu Leu Leu Pro Asn Pro Thr Arg Glu Ile Gly Ser 
865                 870                 875                 880 
Gly Ala Ala Tyr Trp Tyr Ala Leu Asp Asp Val Arg Phe Ser Glu Lys 
                885                 890                 895     
Leu Asn Tyr Asp Tyr Ile Phe Leu Ser Gln Ser Arg Ile Ser Ser Arg 
            900                 905                 910         
Leu Leu Ser Phe Ala Ile Glu Phe Ala Leu Lys Asn Pro Gln Leu Gln 
        915                 920                 925             
Leu Leu Phe Ser Lys His Leu Asp Glu Asn Ile Asp Leu Lys Asn Arg 
    930                 935                 940                 
Ile Ile Pro Asp Asn Leu Ile Ile Ser Thr Glu Ser Ser Ile Gln Gly 
945                 950                 955                 960 
Ile Asn Glu Ser Arg Val Ala Val Gly Val Tyr Ser Thr Ser Leu Phe 
                965                 970                 975     
Glu Ala Leu Ala Cys Gly Lys Gln Thr Phe Val Val Lys Tyr Pro Gly 
            980                 985                 990         
Tyr Glu Ile Met Ser Asn Glu Ile Asp Ser Gly Leu Phe Phe Ala Val 
        995                 1000                1005            
Glu Thr Pro Glu Glu Met Leu Glu Lys Thr Ser Pro Asn Trp Val Ala 
    1010                1015                1020                
Val Ala Asp Ile Glu Asn Gln Phe Phe Gly Gln Glu Lys 
1025                1030                1035        

<210> 108
<211> 1037
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> polymerase of serogroup W-135

<400> 108
Met Ala Val Ile Ile Phe Val Asn Gly Ile Arg Ala Val Asn Gly Leu 
1               5                   10                  15      
Val Lys Ser Ser Ile Asn Thr Ala Asn Ala Phe Ala Glu Glu Gly Leu 
            20                  25                  30          
Asp Val His Leu Ile Asn Phe Val Gly Asn Ile Thr Gly Ala Glu His 
        35                  40                  45              
Leu Tyr Pro Pro Phe His Leu His Pro Asn Val Lys Thr Ser Ser Ile 
    50                  55                  60                  
Ile Asp Leu Phe Asn Asp Ile Pro Glu Asn Val Ser Cys Arg Asn Thr 
65                  70                  75                  80  
Pro Phe Tyr Ser Ile His Gln Gln Phe Phe Lys Ala Glu Tyr Ser Ala 
                85                  90                  95      
His Tyr Lys His Val Leu Met Lys Ile Glu Ser Leu Leu Ser Ala Glu 
            100                 105                 110         
Asp Ser Ile Ile Phe Thr His Pro Leu Gln Leu Glu Met Tyr Arg Leu 
        115                 120                 125             
Ala Asn Asn Asp Ile Lys Ser Lys Ala Lys Leu Ile Val Gln Ile His 
    130                 135                 140                 
Gly Asn Tyr Met Glu Glu Ile His Asn Tyr Glu Ile Leu Ala Arg Asn 
145                 150                 155                 160 
Ile Asp Tyr Val Asp Tyr Leu Gln Thr Val Ser Asp Glu Met Leu Glu 
                165                 170                 175     
Glu Met His Ser His Phe Lys Ile Lys Lys Asp Lys Leu Val Phe Ile 
            180                 185                 190         
Pro Asn Ile Thr Tyr Pro Ile Ser Leu Glu Lys Lys Glu Ala Asp Phe 
        195                 200                 205             
Phe Ile Lys Asp Asn Glu Asp Ile Asp Asn Ala Gln Lys Phe Lys Arg 
    210                 215                 220                 
Ile Ser Ile Val Gly Ser Ile Gln Pro Arg Lys Asn Gln Leu Asp Ala 
225                 230                 235                 240 
Ile Lys Ile Ile Asn Lys Ile Lys Asn Glu Asn Tyr Ile Leu Gln Ile 
                245                 250                 255     
Tyr Gly Lys Ser Ile Asn Lys Asp Tyr Phe Glu Leu Ile Lys Lys Tyr 
            260                 265                 270         
Ile Lys Asp Asn Lys Leu Gln Asn Arg Ile Leu Phe Lys Gly Glu Ser 
        275                 280                 285             
Ser Glu Gln Glu Ile Tyr Glu Asn Thr Asp Ile Leu Ile Met Thr Ser 
    290                 295                 300                 
Glu Ser Glu Gly Phe Pro Tyr Ile Phe Met Glu Gly Met Val Tyr Asp 
305                 310                 315                 320 
Ile Pro Ile Val Val Tyr Asp Phe Lys Tyr Gly Ala Asn Asp Tyr Ser 
                325                 330                 335     
Asn Tyr Asn Glu Asn Gly Cys Val Phe Lys Thr Gly Asp Ile Ser Gly 
            340                 345                 350         
Met Ala Lys Lys Ile Ile Glu Leu Leu Asn Asn Pro Glu Lys Tyr Lys 
        355                 360                 365             
Glu Leu Val Gln Tyr Asn His Asn Arg Phe Leu Lys Glu Tyr Ala Lys 
    370                 375                 380                 
Asp Val Val Met Ala Lys Tyr Phe Thr Ile Leu Pro Arg Ser Phe Asn 
385                 390                 395                 400 
Asn Val Ser Leu Ser Ser Ala Phe Ser Arg Lys Glu Leu Asp Glu Phe 
                405                 410                 415     
Gln Asn Ile Thr Phe Ser Ile Glu Asp Ser Asn Asp Leu Ala His Ile 
            420                 425                 430         
Trp Asn Phe Glu Leu Thr Asn Pro Ala Gln Asn Met Asn Phe Phe Ala 
        435                 440                 445             
Leu Val Gly Lys Arg Lys Phe Pro Met Asp Ala His Ile Gln Gly Thr 
    450                 455                 460                 
Gln Cys Thr Ile Lys Ile Ala His Lys Lys Thr Gly Asn Leu Leu Ser 
465                 470                 475                 480 
Leu Leu Leu Lys Lys Arg Asn Gln Leu Asn Leu Ser Arg Gly Tyr Thr 
                485                 490                 495     
Leu Ile Ala Glu Asp Asn Ser Tyr Glu Lys Tyr Ile Gly Ala Ile Ser 
            500                 505                 510         
Asn Lys Gly Asn Phe Glu Ile Ile Ala Asn Lys Lys Ser Ser Leu Val 
        515                 520                 525             
Thr Ile Asn Lys Ser Thr Leu Glu Leu His Glu Ile Pro His Glu Leu 
    530                 535                 540                 
His Gln Asn Lys Leu Leu Ile Ala Leu Pro Asn Met Gln Thr Pro Leu 
545                 550                 555                 560 
Lys Ile Thr Asp Asp Asn Leu Ile Pro Ile Gln Ala Ser Ile Lys Leu 
                565                 570                 575     
Glu Lys Ile Gly Asn Thr Tyr Tyr Pro Cys Phe Leu Pro Ser Gly Ile 
            580                 585                 590         
Phe Asn Asn Ile Cys Leu Asp Tyr Gly Glu Glu Ser Lys Ile Ile Asn 
        595                 600                 605             
Phe Ser Lys Tyr Ser Tyr Lys Tyr Ile Tyr Asp Ser Ile Arg His Ile 
    610                 615                 620                 
Glu Gln His Thr Asp Ile Ser Asp Ile Ile Val Cys Asn Val Tyr Ser 
625                 630                 635                 640 
Trp Glu Leu Ile Arg Ala Ser Val Ile Glu Ser Leu Met Glu Phe Thr 
                645                 650                 655     
Gly Lys Trp Glu Lys His Phe Gln Thr Ser Pro Lys Ile Asp Tyr Arg 
            660                 665                 670         
Phe Asp His Glu Gly Lys Arg Ser Met Asp Asp Val Phe Ser Glu Glu 
        675                 680                 685             
Thr Phe Ile Met Glu Phe Pro Arg Lys Asn Gly Ile Asp Lys Lys Thr 
    690                 695                 700                 
Ala Ala Phe Gln Asn Ile Pro Asn Ser Ile Val Met Glu Tyr Pro Gln 
705                 710                 715                 720 
Thr Asn Gly Tyr Ser Met Arg Ser His Ser Leu Lys Ser Asn Val Val 
                725                 730                 735     
Ala Ala Lys His Phe Leu Glu Lys Leu Asn Lys Ile Lys Val Asp Ile 
            740                 745                 750         
Lys Phe Lys Lys His Asp Leu Ala Asn Ile Lys Lys Met Asn Arg Ile 
        755                 760                 765             
Ile Tyr Glu His Leu Gly Ile Asn Ile Asn Ile Glu Ala Phe Leu Lys 
    770                 775                 780                 
Pro Arg Leu Glu Lys Phe Lys Arg Glu Glu Lys Tyr Phe His Asp Phe 
785                 790                 795                 800 
Phe Lys Arg Asn Asn Phe Lys Glu Val Ile Phe Pro Ser Thr Tyr Trp 
                805                 810                 815     
Asn Pro Gly Ile Ile Cys Ala Ala His Lys Gln Gly Ile Lys Val Ser 
            820                 825                 830         
Asp Ile Gln Tyr Ala Ala Ile Thr Pro Tyr His Pro Ala Tyr Phe Lys 
        835                 840                 845             
Ser Pro Lys Ser His Tyr Val Ala Asp Lys Leu Phe Leu Trp Ser Glu 
    850                 855                 860                 
Tyr Trp Asn His Glu Leu Leu Pro Asn Pro Thr Arg Glu Ile Gly Ser 
865                 870                 875                 880 
Gly Ala Ala Tyr Trp Tyr Ala Leu Asp Asp Val Arg Phe Ser Glu Lys 
                885                 890                 895     
Leu Asn Tyr Asp Tyr Ile Phe Leu Ser Gln Ser Arg Ile Ser Ser Arg 
            900                 905                 910         
Leu Leu Ser Phe Ala Ile Glu Phe Ala Leu Lys Asn Pro Gln Leu Gln 
        915                 920                 925             
Leu Leu Phe Ser Lys His Pro Asp Glu Asn Ile Asp Leu Lys Asn Arg 
    930                 935                 940                 
Ile Ile Pro Asp Asn Leu Ile Ile Ser Thr Glu Ser Ser Ile Gln Gly 
945                 950                 955                 960 
Ile Asn Glu Ser Arg Val Ala Val Gly Val Tyr Ser Thr Ser Leu Phe 
                965                 970                 975     
Glu Ala Leu Ala Cys Gly Lys Gln Thr Phe Val Val Lys Tyr Pro Gly 
            980                 985                 990         
Tyr Glu Ile Met Ser Asn Glu Ile Asp Ser Gly Leu Phe Phe Ala Val 
        995                 1000                1005            
Glu Thr Pro Glu Glu Met Leu Glu Lys Thr Ser Pro Asn Trp Val Ala 
    1010                1015                1020                
Val Ala Asp Ile Glu Asn Gln Phe Phe Gly Gln Glu Lys 
1025                1030                1035        

<210> 109
<211> 495
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> Polysialyltransferase of NmB

<400> 109
Met Leu Lys Lys Ile Lys Lys Ala Leu Phe Gln Pro Lys Lys Phe Phe 
1               5                   10                  15      
Gln Asp Ser Met Trp Leu Thr Thr Ser Pro Phe Tyr Leu Thr Pro Pro 
            20                  25                  30          
Arg Asn Asn Leu Phe Val Ile Ser Asn Leu Gly Gln Leu Asn Gln Val 
        35                  40                  45              
Gln Ser Leu Ile Lys Ile Gln Lys Leu Thr Asn Asn Leu Leu Val Ile 
    50                  55                  60                  
Leu Tyr Thr Ser Lys Asn Leu Lys Met Pro Lys Leu Val His Gln Ser 
65                  70                  75                  80  
Ala Asn Lys Asn Leu Phe Glu Ser Ile Tyr Leu Phe Glu Leu Pro Arg 
                85                  90                  95      
Ser Pro Asn Asn Ile Thr Pro Lys Lys Leu Leu Tyr Ile Tyr Arg Ser 
            100                 105                 110         
Tyr Lys Lys Ile Leu Asn Ile Ile Gln Pro Ala His Leu Tyr Met Leu 
        115                 120                 125             
Ser Phe Thr Gly His Tyr Ser Tyr Leu Ile Ser Ile Ala Lys Lys Lys 
    130                 135                 140                 
Asn Ile Thr Thr His Leu Ile Asp Glu Gly Thr Gly Thr Tyr Ala Pro 
145                 150                 155                 160 
Leu Leu Glu Ser Phe Ser Tyr His Pro Thr Lys Leu Glu Arg Tyr Leu 
                165                 170                 175     
Ile Gly Asn Asn Leu Asn Ile Lys Gly Tyr Ile Asp His Phe Asp Ile 
            180                 185                 190         
Leu His Val Pro Phe Pro Glu Tyr Ala Lys Lys Ile Phe Asn Ala Lys 
        195                 200                 205             
Lys Tyr Asn Arg Phe Phe Ala His Ala Gly Gly Ile Ser Ile Asn Asn 
    210                 215                 220                 
Asn Ile Ala Asn Leu Gln Lys Lys Tyr Gln Ile Ser Lys Asn Asp Tyr 
225                 230                 235                 240 
Ile Phe Val Ser Gln Arg Tyr Pro Ile Ser Asp Asp Leu Tyr Tyr Lys 
                245                 250                 255     
Ser Ile Val Glu Ile Leu Asn Ser Ile Ser Leu Gln Ile Lys Gly Lys 
            260                 265                 270         
Ile Phe Ile Lys Leu His Pro Lys Glu Met Gly Asn Asn Tyr Val Met 
        275                 280                 285             
Ser Leu Phe Leu Asn Met Val Glu Ile Asn Pro Arg Leu Val Val Ile 
    290                 295                 300                 
Asn Glu Pro Pro Phe Leu Ile Glu Pro Leu Ile Tyr Leu Thr Asn Pro 
305                 310                 315                 320 
Lys Gly Ile Ile Gly Leu Ala Ser Ser Ser Leu Ile Tyr Thr Pro Leu 
                325                 330                 335     
Leu Ser Pro Ser Thr Gln Cys Leu Ser Ile Gly Glu Leu Ile Ile Asn 
            340                 345                 350         
Leu Ile Gln Lys Tyr Ser Met Val Glu Asn Thr Glu Met Ile Gln Glu 
        355                 360                 365             
His Leu Glu Ile Ile Lys Lys Phe Asn Phe Ile Asn Ile Leu Asn Asp 
    370                 375                 380                 
Leu Asn Gly Val Ile Ser Asn Pro Leu Phe Lys Thr Glu Glu Thr Phe 
385                 390                 395                 400 
Glu Thr Leu Leu Lys Ser Ala Glu Phe Ala Tyr Lys Ser Lys Asn Tyr 
                405                 410                 415     
Phe Gln Ala Ile Phe Tyr Trp Gln Leu Ala Ser Lys Asn Asn Ile Thr 
            420                 425                 430         
Leu Leu Gly His Lys Ala Leu Trp Tyr Tyr Asn Ala Leu Tyr Asn Val 
        435                 440                 445             
Lys Gln Ile Tyr Lys Met Glu Tyr Ser Asp Ile Phe Tyr Ile Asp Asn 
    450                 455                 460                 
Ile Ser Val Asp Phe His Ser Lys Asp Lys Leu Thr Trp Glu Lys Ile 
465                 470                 475                 480 
Lys His Tyr Tyr Tyr Ser Ala Asp Asn Arg Ile Gly Arg Asp Arg 
                485                 490                 495 

<210> 110
<211> 492
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> Polysialyltransferase of NmC

<400> 110
Met Leu Gln Lys Ile Arg Lys Ala Leu Phe His Pro Lys Lys Phe Phe 
1               5                   10                  15      
Gln Asp Ser Gln Trp Phe Ala Thr Pro Leu Phe Ser Ser Phe Ala Pro 
            20                  25                  30          
Lys Ser Asn Leu Phe Ile Ile Ser Thr Phe Ala Gln Leu Asn Gln Ala 
        35                  40                  45              
His Ser Leu Thr Lys Met Gln Lys Leu Lys Asn Asn Leu Leu Val Ile 
    50                  55                  60                  
Leu Tyr Thr Thr Gln Asn Met Lys Met Pro Lys Leu Ile Gln Lys Ser 
65                  70                  75                  80  
Val Asp Lys Glu Leu Phe Ser Val Thr Tyr Met Phe Glu Leu Pro Arg 
                85                  90                  95      
Lys Pro Gly Ile Val Ser Pro Lys Lys Phe Leu Tyr Ile Gln Arg Gly 
            100                 105                 110         
Tyr Lys Lys Leu Leu Lys Thr Ile Gln Pro Ala His Leu Tyr Val Met 
        115                 120                 125             
Ser Phe Ala Gly His Tyr Ser Ser Leu Leu Ser Leu Ala Lys Lys Met 
    130                 135                 140                 
Asn Ile Thr Thr His Leu Val Glu Glu Gly Thr Ala Thr Tyr Ala Pro 
145                 150                 155                 160 
Leu Leu Glu Ser Phe Thr Tyr Lys Pro Thr Lys Phe Glu Gln Arg Phe 
                165                 170                 175     
Val Gly Asn Asn Leu His Gln Lys Gly Tyr Phe Asp Lys Phe Asp Ile 
            180                 185                 190         
Leu His Val Ala Phe Pro Glu Tyr Ala Lys Lys Ile Phe Asn Ala Asn 
        195                 200                 205             
Glu Tyr His Arg Phe Phe Ala His Ser Gly Gly Ile Ser Thr Ser Gln 
    210                 215                 220                 
Ser Ile Ala Lys Ile Gln Asp Lys Tyr Arg Ile Ser Gln Asn Asp Tyr 
225                 230                 235                 240 
Ile Phe Val Ser Gln Arg Tyr Pro Val Ser Asp Glu Val Tyr Tyr Lys 
                245                 250                 255     
Thr Ile Val Glu Thr Leu Asn Gln Met Ser Leu Arg Ile Glu Gly Lys 
            260                 265                 270         
Ile Phe Ile Lys Leu His Pro Lys Glu Met Glu Asn Lys Asn Ile Met 
        275                 280                 285             
Ser Leu Phe Leu Asn Met Val Thr Ile Asn Pro Arg Leu Val Val Ile 
    290                 295                 300                 
Asn Glu Pro Pro Phe Leu Ile Asp Pro Leu Ile Tyr Leu Thr Thr Pro 
305                 310                 315                 320 
Lys Gly Ile Ile Gly Leu Thr Ser Thr Ser Ile Val Tyr Thr Pro Leu 
                325                 330                 335     
Leu Ser Pro Thr Thr Gln Cys Leu Ser Ile Gly Gln Ile Val Ile Asp 
            340                 345                 350         
Ser Ile His His Thr Ala Gln Gln Glu Asn Thr Ala Leu Ile Glu Glu 
        355                 360                 365             
His Leu Glu Ile Val Lys Gln Phe Asp Phe Ile Lys Ile Leu Ser Ser 
    370                 375                 380                 
Ile Glu Asp Gly Ile Asp Thr Asn Ser Phe Lys Thr Glu Glu Thr Leu 
385                 390                 395                 400 
Glu Met Leu Leu Lys Ser Ala Glu Tyr Ala Tyr Lys Asn Lys Asn Phe 
                405                 410                 415     
Tyr Gln Ala Ile Phe Tyr Trp Gln Leu Ala Ser Asn Asn Asp Leu Ser 
            420                 425                 430         
Val Leu Gly Tyr Lys Ser Leu Trp Tyr Tyr Asn Ala Leu Asn Lys Val 
        435                 440                 445             
Lys Gln Asn Tyr Lys Met Lys Tyr Leu Glu Ile Asn Tyr Ile Glu Arg 
    450                 455                 460                 
Ile Ser Leu Tyr Phe Asn Asp Lys Asp Lys Met Ile Trp Gln Asn Ile 
465                 470                 475                 480 
Lys Asn Asp Phe Phe Lys Tyr Ser Leu Cys Asn Gln 
                485                 490         

<210> 111
<211> 409
<212> PRT
<213> Escherichia coli

<220> 
<223> Escherichia coli K1

<400> 111
Met Ile Phe Asp Ala Ser Leu Lys Lys Leu Arg Lys Leu Phe Val Asn 
1               5                   10                  15      
Pro Ile Gly Phe Phe Arg Asp Ser Trp Phe Phe Asn Ser Lys Asn Lys 
            20                  25                  30          
Ala Glu Glu Leu Leu Ser Pro Leu Lys Ile Lys Ser Lys Asn Ile Phe 
        35                  40                  45              
Ile Ile Ser Asn Leu Gly Gln Leu Lys Lys Ala Glu Ser Phe Val Gln 
    50                  55                  60                  
Lys Phe Ser Lys Arg Ser Asn Tyr Leu Ile Val Leu Ala Thr Glu Lys 
65                  70                  75                  80  
Asn Thr Glu Met Pro Lys Ile Ile Val Glu Gln Ile Asn Asn Lys Leu 
                85                  90                  95      
Phe Ser Ser Tyr Lys Val Leu Phe Ile Pro Thr Phe Pro Asn Val Phe 
            100                 105                 110         
Ser Leu Lys Lys Val Ile Trp Phe Tyr Asn Val Tyr Asn Tyr Leu Val 
        115                 120                 125             
Leu Asn Ser Lys Ala Lys Asp Ala Tyr Phe Met Ser Tyr Ala Gln His 
    130                 135                 140                 
Tyr Ala Ile Phe Val Tyr Leu Phe Lys Lys Asn Asn Ile Arg Cys Ser 
145                 150                 155                 160 
Leu Ile Glu Glu Gly Thr Gly Thr Tyr Lys Thr Glu Lys Glu Asn Pro 
                165                 170                 175     
Val Val Asn Ile Asn Phe Tyr Ser Glu Ile Ile Asn Ser Ile Ile Leu 
            180                 185                 190         
Phe His Tyr Pro Asp Leu Lys Phe Glu Asn Val Tyr Gly Thr Tyr Pro 
        195                 200                 205             
Ile Leu Leu Lys Lys Lys Phe Asn Ala Gln Lys Phe Val Glu Phe Lys 
    210                 215                 220                 
Gly Ala Pro Ser Val Lys Ser Ser Thr Arg Ile Asp Asn Val Ile His 
225                 230                 235                 240 
Lys Tyr Ser Ile Thr Arg Asp Asp Ile Ile Tyr Ala Asn Gln Lys Tyr 
                245                 250                 255     
Leu Ile Glu His Thr Leu Phe Ala Asp Ser Leu Ile Ser Ile Leu Leu 
            260                 265                 270         
Arg Ile Asp Lys Pro Asp Asn Ala Arg Ile Phe Ile Lys Pro His Pro 
        275                 280                 285             
Lys Glu Pro Lys Lys Asn Ile Asn Ala Ile Gln Lys Ala Ile Lys Lys 
    290                 295                 300                 
Ala Lys Cys Arg Asp Ile Ile Leu Ile Thr Glu Pro Asp Phe Leu Ile 
305                 310                 315                 320 
Glu Pro Val Ile Lys Lys Ala Lys Ile Lys His Leu Ile Gly Leu Thr 
                325                 330                 335     
Ser Ser Ser Leu Val Tyr Ala Pro Leu Val Ser Lys Arg Cys Gln Ser 
            340                 345                 350         
Tyr Ser Ile Ala Pro Leu Met Ile Lys Leu Cys Asp Asn Asp Lys Ser 
        355                 360                 365             
Gln Lys Gly Ile Asn Thr Leu Arg Leu His Phe Asp Ile Leu Lys Asn 
    370                 375                 380                 
Phe Asp Asn Val Lys Ile Leu Ser Asp Asp Ile Thr Ser Pro Ser Leu 
385                 390                 395                 400 
His Asp Lys Arg Ile Phe Leu Gly Glu 
                405                 

<210> 112
<211> 409
<212> PRT
<213> Escherichia coli

<220> 
<223> Escherichia coli K92

<400> 112
Met Ile Phe Asp Ala Ser Leu Lys Lys Leu Arg Lys Leu Phe Val Asn 
1               5                   10                  15      
Pro Ile Gly Phe Phe Arg Asp Ser Trp Phe Phe Asn Ser Lys Asn Lys 
            20                  25                  30          
Ala Glu Glu Leu Leu Ser Pro Leu Lys Ile Lys Ser Lys Asn Ile Phe 
        35                  40                  45              
Ile Val Ala His Leu Gly Gln Leu Lys Lys Ala Glu Leu Phe Ile Gln 
    50                  55                  60                  
Lys Phe Ser Arg Arg Ser Asn Phe Leu Ile Val Leu Ala Thr Lys Lys 
65                  70                  75                  80  
Asn Thr Glu Met Pro Arg Leu Ile Leu Glu Gln Met Asn Lys Lys Leu 
                85                  90                  95      
Phe Ser Ser Tyr Lys Leu Leu Phe Ile Pro Thr Glu Pro Asn Thr Phe 
            100                 105                 110         
Ser Leu Lys Lys Val Ile Trp Phe Tyr Asn Val Tyr Lys Tyr Ile Val 
        115                 120                 125             
Leu Asn Ser Lys Ala Lys Asp Ala Tyr Phe Met Ser Tyr Ala Gln His 
    130                 135                 140                 
Tyr Ala Ile Phe Ile Trp Leu Phe Lys Lys Asn Asn Ile Arg Cys Ser 
145                 150                 155                 160 
Leu Ile Glu Glu Gly Thr Gly Thr Tyr Lys Thr Glu Lys Lys Lys Pro 
                165                 170                 175     
Leu Val Asn Ile Asn Phe Tyr Ser Trp Ile Ile Asn Ser Ile Ile Leu 
            180                 185                 190         
Phe His Tyr Pro Asp Leu Lys Phe Glu Asn Val Tyr Gly Thr Phe Pro 
        195                 200                 205             
Asn Leu Leu Lys Glu Lys Phe Asp Ala Lys Lys Ile Phe Glu Phe Lys 
    210                 215                 220                 
Thr Ile Pro Leu Val Lys Ser Ser Thr Arg Met Asp Asn Leu Ile His 
225                 230                 235                 240 
Lys Tyr Arg Ile Thr Arg Asp Asp Ile Ile Tyr Val Ser Gln Arg Tyr 
                245                 250                 255     
Trp Ile Asp Asn Glu Leu Tyr Ala His Leu Leu Ile Ser Thr Leu Met 
            260                 265                 270         
Arg Ile Asp Lys Ser Asp Asn Ala Arg Val Phe Ile Lys Pro His Pro 
        275                 280                 285             
Lys Glu Thr Lys Lys Tyr Ile Asn Ala Ile Gln Gly Ala Ile Asn Lys 
    290                 295                 300                 
Ala Lys Arg Arg Asp Ile Ile Ile Ile Val Glu Lys Asp Phe Leu Ile 
305                 310                 315                 320 
Glu Ser Ile Ile Lys Lys Cys Lys Ile Lys His Leu Ile Gly Leu Ala 
                325                 330                 335     
Ser Ser Ser Leu Val Tyr Ala Pro Leu Val Tyr Lys Glu Cys Lys Thr 
            340                 345                 350         
Tyr Ser Ile Ala Pro Ile Ile Ile Lys Leu Cys Asn Asn Glu Lys Ser 
        355                 360                 365             
Gln Lys Gly Ile Asn Thr Leu Arg Leu His Phe Asp Ile Leu Lys Asn 
    370                 375                 380                 
Phe Asp Asn Val Lys Ile Leu Ser Asp Asp Ile Thr Ser Pro Ser Leu 
385                 390                 395                 400 
His Asp Lys Arg Ile Phe Leu Gly Glu 
                405                 

<210> 113
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-deltaN235-CsaB-His6

<400> 113
gcagatctat tgatttagta tttacttgg                                      29


<210> 114
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-deltaN235-CsaB-His6

<400> 114
ccgctcgagt ttctcaaatg atgatggtaa tg                                   32


<210> 115
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-deltaN167-CsaB-His6

<400> 115
gcagatctac tttaagttca tctatatct                                      29


<210> 116
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-deltaN167-CsaB-His6

<400> 116
ccgctcgagt ttctcaaatg atgatggtaa tg                                   32


<210> 117
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-deltaN97-CsaB-His6

<400> 117
gcagatctcc ttctaatctt actcttaagc                                     30


<210> 118
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-deltaN97-CsaB-His6

<400> 118
ccgctcgagt ttctcaaatg atgatggtaa tg                                   32


<210> 119
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-deltaC41-CsaB-His6

<400> 119
gcagatcttt tatacttaat aacagaaaat ggc                                  33


<210> 120
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-deltaC41-CsaB-His6

<400> 120
cgcctcgaga aaattccttt ctttagttaa gg                                   32


<210> 121
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-deltaC25-CsaB-His6

<400> 121
gcagatcttt tatacttaat aacagaaaat ggc                                  33


<210> 122
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer StrepII-deltaC25-CsaB-His6

<400> 122
cgcctcgagg tgactatcag caccatcg                                       28


<210> 123
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer MBP-deltaN58-CsxA-His6

<400> 123
cgggatcccc aattgaagat ccatacccag ta                                   32


<210> 124
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer MBP-deltaN58-CsxA-His6

<400> 124
ccgctcgagt tgtccactag gctgtgatg                                      29


<210> 125
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer MBP-deltaC99-CsxA-His6

<400> 125
gcggatccat tatgagcaaa attagcaaat tg                                   32


<210> 126
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer MBP-deltaC99-CsxA-His6

<400> 126
ccgctcgagg agaatttctg cttctgatac atc                                  33


<210> 127
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer MBP-deltaN58deltaC99-CsxA-His6

<400> 127
cgggatcccc aattgaagat ccatacccag ta                                   32


<210> 128
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer MBP-deltaN58deltaC99-CsxA-His6

<400> 128
ccgctcgagg agaatttctg cttctgatac atc                                  33


<210> 129
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer MBP-deltaN104-CsxA-His6

<400> 129
cgggatccga aagcaccgat attgcaagat tcc                                  33


<210> 130
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer MBP-deltaN104-CsxA-His6

<400> 130
ccgctcgagg agaatttctg cttctgatac atc                                  33


<210> 131
<211> 32
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer MBP-deltaC174-CsxA-His6

<400> 131
gcggatccat tatgagcaaa attagcaaat tg                                   32


<210> 132
<211> 37
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer MBP-deltaC174-CsxA-His6

<400> 132
ccgctcgagt tggcctgtca aaatggcaaa atggtgg                              37


<210> 133
<211> 58
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> Fragment Figure 7 CslA

<400> 133
Thr Phe Leu Val Pro Trp Leu Met Tyr Leu Asp Gly Lys Ser Ile Pro 
1               5                   10                  15      
Asn Asn Asp Ile Cys Tyr Tyr Phe Asn Ile Arg Ser Asn Lys Ala Pro 
            20                  25                  30          
Thr Gln Tyr Leu Lys Leu Leu Gln Lys Asn Glu Asp Asn Gln Gln Pro 
        35                  40                  45              
His Ser Phe Cys Ala Asn Asp Phe His Ser 
    50                  55              

<210> 134
<211> 60
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> Fragment Figure 7 CsaB

<400> 134
Gly Tyr Leu Tyr His His Tyr Ala Leu Leu Ser Gly Arg Ala Leu Gln 
1               5                   10                  15      
Ser Ser Asp Lys Thr Glu Leu Val Gln Gln Asn His Asp Phe Lys Lys 
            20                  25                  30          
Lys Leu Asn Asn Val Val Thr Leu Thr Lys Glu Arg Asn Phe Asp Lys 
        35                  40                  45              
Leu Pro Leu Ser Val Cys Ile Asn Asp Gly Ala Asp 
    50                  55                  60  

<210> 135
<211> 58
<212> PRT
<213> Neisseria meningitidis

<220> 
<223> Fragment Figure 7 CsxA

<400> 135
Thr Phe Leu His His His Phe Ala Ile Leu Thr Gly Gln Ala Leu Ala 
1               5                   10                  15      
Thr Arg Thr Lys Cys Ile Tyr Phe Asn Ile Arg Ser Pro Gln Ala Ala 
            20                  25                  30          
Gln His Tyr Lys Thr Leu Leu Ala Arg Lys Gly Ser Glu Tyr Ser Pro 
        35                  40                  45              
His Ser Ile Cys Leu Asn Asp His Thr Ser 
    50                  55              

