                         SEQUENCE LISTING

<110>  Inserm
 
<120>  METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF 
       CANCER

<130>  BIO14017 FORGEZ / EP

<160>  6     

<170>  PatentIn version 3.3

<210>  1
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Met Ala Gly Met Lys Ile Gln Leu Val Cys Met Leu Leu Leu Ala 
1               5                   10                  15      


Phe Ser Ser Trp Ser Leu Cys Ser Asp Ser Glu Glu Glu Met Lys Ala 
            20                  25                  30          


Leu Glu Ala Asp Phe Leu Thr Asn Met His Thr Ser Lys Ile Ser Lys 
        35                  40                  45              


Ala His Val Pro Ser Trp Lys Met Thr Leu Leu Asn Val Cys Ser Leu 
    50                  55                  60                  


Val Asn Asn Leu Asn Ser Pro Ala Glu Glu Thr Gly Glu Val His Glu 
65                  70                  75                  80  


Glu Glu Leu Val Ala Arg Arg Lys Leu Pro Thr Ala Leu Asp Gly Phe 
                85                  90                  95      


Ser Leu Glu Ala Met Leu Thr Ile Tyr Gln Leu His Lys Ile Cys His 
            100                 105                 110         


Ser Arg Ala Phe Gln His Trp Glu Leu Ile Gln Glu Asp Ile Leu Asp 
        115                 120                 125             


Thr Gly Asn Asp Lys Asn Gly Lys Glu Glu Val Ile Lys Arg Lys Ile 
    130                 135                 140                 


Pro Tyr Ile Leu Lys Arg Gln Leu Tyr Glu Asn Lys Pro Arg Arg Pro 
145                 150                 155                 160 


Tyr Ile Leu Lys Arg Asp Ser Tyr Tyr Tyr 
                165                 170 


<210>  2
<211>  140
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Asp Ser Glu Glu Glu Met Lys Ala Leu Glu Ala Asp Phe Leu Thr 
1               5                   10                  15      


Asn Met His Thr Ser Lys Ile Ser Lys Ala His Val Pro Ser Trp Lys 
            20                  25                  30          


Met Thr Leu Leu Asn Val Cys Ser Leu Val Asn Asn Leu Asn Ser Pro 
        35                  40                  45              


Ala Glu Glu Thr Gly Glu Val His Glu Glu Glu Leu Val Ala Arg Arg 
    50                  55                  60                  


Lys Leu Pro Thr Ala Leu Asp Gly Phe Ser Leu Glu Ala Met Leu Thr 
65                  70                  75                  80  


Ile Tyr Gln Leu His Lys Ile Cys His Ser Arg Ala Phe Gln His Trp 
                85                  90                  95      


Glu Leu Ile Gln Glu Asp Ile Leu Asp Thr Gly Asn Asp Lys Asn Gly 
            100                 105                 110         


Lys Glu Glu Val Ile Lys Arg Lys Ile Pro Tyr Ile Leu Lys Arg Gln 
        115                 120                 125             


Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
    130                 135                 140 


<210>  3
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 
1               5                   10              


<210>  4
<211>  1232
<212>  DNA
<213>  Homo sapiens

<400>  4
gctgaaggaa agaggaagtg ctagagagag cccccttcag tgtgcttctg acttttacgg     60

acttggcttg ttagaaggct gaaagatgat ggcaggaatg aaaatccagc ttgtatgcat    120

gctactcctg gctttcagct cctggagtct gtgctcagat tcagaagagg aaatgaaagc    180

attagaagca gatttcttga ccaatatgca tacatcaaag attagtaaag cacatgttcc    240

ctcttggaag atgactctgc taaatgtttg cagtcttgta aataatttga acagcccagc    300

tgaggaaaca ggagaagttc atgaagagga gcttgttgca agaaggaaac ttcctactgc    360

tttagatggc tttagcttgg aagcaatgtt gacaatatac cagctccaca aaatctgtca    420

cagcagggct tttcaacact gggagttaat ccaggaagat attcttgata ctggaaatga    480

caaaaatgga aaggaagaag tcataaagag aaaaattcct tatattctga aacggcagct    540

gtatgagaat aaacccagaa gaccctacat actcaaaaga gattcttact attactgaga    600

gaataaatca tttatttaca tgtgattgtg attcatcatc ccttaattaa atatcaaatt    660

atatttgtgt gaaaatgtga caaacacact tatctgtctc ttctacaatt gtggtttatt    720

gaatgtgatt tttctgcact aatataaatt agactaagtg ttttcaaata aatctaaatc    780

ttcagcatga tgtgttgtgt ataattggag tagatattaa ttaagtcacc tgtataatgt    840

tttgtaattt tgcaaaacat atcttgagtt gtttaaacag tcaaaatgtt tgatatttta    900

taccagctta tgagctcaaa gtactacagc aaagcctagc ctgcatatca ttcacccaaa    960

acaaagtaat agcgcctctt ttattatttt gactgaatgt tttatggaat tgaaagaaac   1020

atacgttctt ttcaagactt cctcatgaat ctctcaatta taggaaaagt tattgtgata   1080

aaataggaac agctgaaaga ttgattaatg aactattgtt aattcttcct attttaatga   1140

atgacattga actgaatttt ttgtctgtta aatgaacttg atagctaata aaaagacaac   1200

tagccatcaa aatcaaaaaa aaaaaaaaaa aa                                 1232


<210>  5
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Arg Leu Asn Ser Ser Ala Pro Gly Thr Pro Gly Thr Pro Ala Ala 
1               5                   10                  15      


Asp Pro Phe Gln Arg Ala Gln Ala Gly Leu Glu Glu Ala Leu Leu Ala 
            20                  25                  30          


Pro Gly Phe Gly Asn Ala Ser Gly Asn Ala Ser Glu Arg Val Leu Ala 
        35                  40                  45              


Ala Pro Ser Ser Glu Leu Asp Val Asn Thr Asp Ile Tyr Ser Lys Val 
    50                  55                  60                  


Leu Val Thr Ala Val Tyr Leu Ala Leu Phe Val Val Gly Thr Val Gly 
65                  70                  75                  80  


Asn Thr Val Thr Ala Phe Thr Leu Ala Arg Lys Lys Ser Leu Gln Ser 
                85                  90                  95      


Leu Gln Ser Thr Val His Tyr His Leu Gly Ser Leu Ala Leu Ser Asp 
            100                 105                 110         


Leu Leu Thr Leu Leu Leu Ala Met Pro Val Glu Leu Tyr Asn Phe Ile 
        115                 120                 125             


Trp Val His His Pro Trp Ala Phe Gly Asp Ala Gly Cys Arg Gly Tyr 
    130                 135                 140                 


Tyr Phe Leu Arg Asp Ala Cys Thr Tyr Ala Thr Ala Leu Asn Val Ala 
145                 150                 155                 160 


Ser Leu Ser Val Glu Arg Tyr Leu Ala Ile Cys His Pro Phe Lys Ala 
                165                 170                 175     


Lys Thr Leu Met Ser Arg Ser Arg Thr Lys Lys Phe Ile Ser Ala Ile 
            180                 185                 190         


Trp Leu Ala Ser Ala Leu Leu Ala Val Pro Met Leu Phe Thr Met Gly 
        195                 200                 205             


Glu Gln Asn Arg Ser Ala Asp Gly Gln His Ala Gly Gly Leu Val Cys 
    210                 215                 220                 


Thr Pro Thr Ile His Thr Ala Thr Val Lys Val Val Ile Gln Val Asn 
225                 230                 235                 240 


Thr Phe Met Ser Phe Ile Phe Pro Met Val Val Ile Ser Val Leu Asn 
                245                 250                 255     


Thr Ile Ile Ala Asn Lys Leu Thr Val Met Val Arg Gln Ala Ala Glu 
            260                 265                 270         


Gln Gly Gln Val Cys Thr Val Gly Gly Glu His Ser Thr Phe Ser Met 
        275                 280                 285             


Ala Ile Glu Pro Gly Arg Val Gln Ala Leu Arg His Gly Val Arg Val 
    290                 295                 300                 


Leu Arg Ala Val Val Ile Ala Phe Val Val Cys Trp Leu Pro Tyr His 
305                 310                 315                 320 


Val Arg Arg Leu Met Phe Cys Tyr Ile Ser Asp Glu Gln Trp Thr Pro 
                325                 330                 335     


Phe Leu Tyr Asp Phe Tyr His Tyr Phe Tyr Met Val Thr Asn Ala Leu 
            340                 345                 350         


Phe Tyr Val Ser Ser Thr Ile Asn Pro Ile Leu Tyr Asn Leu Val Ser 
        355                 360                 365             


Ala Asn Phe Arg His Ile Phe Leu Ala Thr Leu Ala Cys Leu Cys Pro 
    370                 375                 380                 


Val Trp Arg Arg Arg Arg Lys Arg Pro Ala Phe Ser Arg Lys Ala Asp 
385                 390                 395                 400 


Ser Val Ser Ser Asn His Thr Leu Ser Ser Asn Ala Thr Arg Glu Thr 
                405                 410                 415     


Leu Tyr 
        


<210>  6
<211>  1257
<212>  DNA
<213>  Homo sapiens

<400>  6
atgcgcctca acagctccgc gccgggaacc ccgggcacgc cggccgccga ccccttccag     60

cgggcgcagg ccggactgga ggaggcgctg ctggccccgg gcttcggcaa cgcttcgggc    120

aacgcgtcgg agcgcgtcct ggcggcaccc agcagcgagc tggacgtgaa caccgacatc    180

tactccaagg tgctggtgac cgccgtgtac ctggcgctct tcgtggtggg cacggtgggc    240

aacacggtga cggcgttcac gctggcgcgg aagaagtcgc tgcagagcct gcagagcacg    300

gtgcattacc acctgggcag cctggcgctg tccgacctgc tcaccctgct gctggccatg    360

cccgtggagc tgtacaactt catctgggtg caccacccct gggccttcgg cgacgccggc    420

tgccgcggct actacttcct gcgcgacgcc tgcacctacg ccacggccct caacgtggcc    480

agcctgagtg tggagcgcta cctggccatc tgccacccct tcaaggccaa gaccctcatg    540

tcccgaagcc gcaccaagaa gttcatcagc gccatctggc tcgcctcggc cctgctggcg    600

gtgcctatgc tgttcaccat gggcgagcag aaccgcagcg ccgacggcca gcacgccggc    660

ggcctggtgt gcacccccac catccacact gccaccgtca aggtcgtcat acaggtcaac    720

accttcatgt ccttcatatt ccccatggtg gtcatctcgg tcctgaacac catcatcgcc    780

aacaagctga ccgtcatggt acgccaggcg gccgagcagg gccaagtgtg cacggtcggg    840

ggcgagcaca gcacattcag catggccatc gagcctggca gggtccaggc cctgcggcac    900

ggcgtgcgcg tcctacgtgc agtggtcatc gcctttgtgg tctgctggct gccctaccac    960

gtgcggcgcc tcatgttctg ctacatctcg gatgagcagt ggactccgtt cctctatgac   1020

ttctaccact acttctacat ggtgaccaac gcactcttct acgtcagctc caccatcaac   1080

cccatcctgt acaacctcgt ctctgccaac ttccgccaca tcttcctggc cacactggcc   1140

tgcctctgcc cggtgtggcg gcgcaggagg aagaggccag ccttctcgag gaaggccgac   1200

agcgtgtcca gcaaccacac cctctccagc aatgccaccc gcgagacgct gtactag      1257


