                         SEQUENCE LISTING

<110>  ASSOCIATION INSTITUT DE MYOLOGIE ET AL.
 
<120>  TREATMENT OF MYOTONIC DYSTROPHY

<130>  B1798PC01

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  130
<212>  PRT
<213>  homo sapiens

<400>  1

Thr Gln Ser Ala Val Lys Ser Leu Lys Arg Pro Leu Glu Ala Thr Phe 
1               5                   10                  15      


Asp Leu Gly Ile Pro Gln Ala Val Leu Pro Pro Leu Pro Lys Arg Pro 
            20                  25                  30          


Ala Leu Glu Lys Thr Asn Gly Ala Thr Ala Val Phe Asn Thr Gly Ile 
        35                  40                  45              


Phe Gln Tyr Gln Gln Ala Leu Ala Asn Met Gln Leu Gln Gln His Thr 
    50                  55                  60                  


Ala Phe Leu Pro Pro Gly Ser Ile Leu Cys Met Thr Pro Ala Thr Ser 
65                  70                  75                  80  


Val Val Pro Met Val His Gly Ala Thr Pro Ala Thr Val Ser Ala Ala 
                85                  90                  95      


Thr Thr Ser Ala Thr Ser Val Pro Phe Ala Ala Thr Thr Ala Asn Gln 
            100                 105                 110         


Ile Pro Ile Ile Ser Ala Glu His Leu Thr Ser His Lys Tyr Val Thr 
        115                 120                 125             


Gln Met 
    130 


<210>  2
<211>  269
<212>  PRT
<213>  artificial

<220>
<223>  delta-CT3 MBNL1-derived polypeptide

<400>  2

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Pro Met Phe Ser Val Ala Pro Ser Leu Ala Thr Asn Ala 
        115                 120                 125             


Ser Ala Ala Ala Phe Asn Pro Tyr Leu Gly Pro Val Ser Pro Ser Leu 
    130                 135                 140                 


Val Pro Ala Glu Ile Leu Pro Thr Ala Pro Met Leu Val Thr Gly Asn 
145                 150                 155                 160 


Pro Gly Val Pro Val Pro Ala Ala Ala Ala Ala Ala Ala Gln Lys Leu 
                165                 170                 175     


Met Arg Thr Asp Arg Leu Glu Val Cys Arg Glu Tyr Gln Arg Gly Asn 
            180                 185                 190         


Cys Asn Arg Gly Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser 
        195                 200                 205             


Thr Met Ile Asp Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr 
    210                 215                 220                 


Ile Lys Gly Arg Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro 
225                 230                 235                 240 


Ala His Leu Gln Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln 
                245                 250                 255     


Ala Ala Ala Ala Gln Ala Ala Ala Thr Ala Ala Ala Met 
            260                 265                 


<210>  3
<211>  201
<212>  PRT
<213>  artificial

<220>
<223>  delta-CT MBNL1-derived polypeptide

<400>  3

Met Ala Val Ser Val Thr Pro Ile Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Glu Phe Gln Arg Gly Thr Cys Ser Arg Pro Asp Thr 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Ser Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Pro His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Asn Met Ala Met Leu 
                85                  90                  95      


Ala Gln Gln Met Gln Leu Ala Asn Ala Met Met Pro Gly Ala Pro Leu 
            100                 105                 110         


Gln Pro Val Val Cys Arg Glu Tyr Gln Arg Gly Asn Cys Asn Arg Gly 
        115                 120                 125             


Glu Asn Asp Cys Arg Phe Ala His Pro Ala Asp Ser Thr Met Ile Asp 
    130                 135                 140                 


Thr Asn Asp Asn Thr Val Thr Val Cys Met Asp Tyr Ile Lys Gly Arg 
145                 150                 155                 160 


Cys Ser Arg Glu Lys Cys Lys Tyr Phe His Pro Pro Ala His Leu Gln 
                165                 170                 175     


Ala Lys Ile Lys Ala Ala Gln Tyr Gln Val Asn Gln Ala Ala Ala Ala 
            180                 185                 190         


Gln Ala Ala Ala Thr Ala Ala Ala Met 
        195                 200     


<210>  4
<211>  268
<212>  PRT
<213>  artificial

<220>
<223>  delta-CT3 MBNL2-derived polypeptide

<400>  4

Met Ala Leu Asn Val Ala Pro Val Arg Asp Thr Lys Trp Leu Thr Leu 
1               5                   10                  15      


Glu Val Cys Arg Gln Phe Gln Arg Gly Thr Cys Ser Arg Ser Asp Glu 
            20                  25                  30          


Glu Cys Lys Phe Ala His Pro Pro Lys Ser Cys Gln Val Glu Asn Gly 
        35                  40                  45              


Arg Val Ile Ala Cys Phe Asp Ser Leu Lys Gly Arg Cys Ser Arg Glu 
    50                  55                  60                  


Asn Cys Lys Tyr Leu His Pro Pro Thr His Leu Lys Thr Gln Leu Glu 
65                  70                  75                  80  


Ile Asn Gly Arg Asn Asn Leu Ile Gln Gln Lys Thr Ala Ala Ala Met 
                85                  90                  95      


Leu Ala Gln Gln Met Gln Phe Met Phe Pro Gly Thr Pro Leu His Pro 
            100                 105                 110         


Val Pro Thr Phe Pro Val Gly Pro Ala Ile Gly Thr Asn Thr Ala Ile 
        115                 120                 125             


Ser Phe Ala Pro Tyr Leu Ala Pro Val Thr Pro Gly Val Gly Leu Val 
    130                 135                 140                 


Pro Thr Glu Ile Leu Pro Thr Thr Pro Val Ile Val Pro Gly Ser Pro 
145                 150                 155                 160 


Pro Val Thr Val Pro Gly Ser Thr Ala Thr Gln Lys Leu Leu Arg Thr 
                165                 170                 175     


Asp Lys Leu Glu Val Cys Arg Glu Phe Gln Arg Gly Asn Cys Ala Arg 
            180                 185                 190         


Gly Glu Thr Asp Cys Arg Phe Ala His Pro Ala Asp Ser Thr Met Ile 
        195                 200                 205             


Asp Thr Ser Asp Asn Thr Val Thr Val Cys Met Asp Tyr Ile Lys Gly 
    210                 215                 220                 


Arg Cys Met Arg Glu Lys Cys Lys Tyr Phe His Pro Pro Ala His Leu 
225                 230                 235                 240 


Gln Ala Lys Ile Lys Ala Ala Gln His Gln Ala Asn Gln Ala Ala Val 
                245                 250                 255     


Ala Ala Gln Ala Ala Ala Ala Ala Ala Thr Val Met 
            260                 265             


<210>  5
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  NLS

<400>  5

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  6
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  NES

<400>  6

Leu Pro Pro Leu Glu Arg Leu Thr Leu Asp 
1               5                   10  


<210>  7
<211>  568
<212>  DNA
<213>  artificial

<220>
<223>  mutated MBNL minigene

<400>  7
cctttcaccc aggagcaaac gcacatcacc tgtgtcctca tctgatggcc ctggtgtggg       60

gcacagtcgt gttggcaggg agggaggtgg ggttggtccc ctttgtgggt ttgttgcgag      120

gccgtgttcc agctgtttcc acagggagcg attttcagct ccacaggaca cagctcccca      180

gttcctcctg agaacaaaag ggggttctgg ggagaggcca ccgttctgag ggctcactgt      240

atgtgttcca gaatctcccc tgcagacccc cactgaggac ggatctgagg aaccgggctc      300

tgaaacctct gaccgtaaga gcactccaac agcggaaggt gggcccccct tcagacgccc      360

cctccagcct ccagcctgta cttagcctac tttgagcctc cctcctggct gcatctacgc      420

tccccctggc tgagagatgt cactccttcg gtactcagga cagcgtggtg ggagctgagc      480

cttcgattac ttactggttg agtgtgggca ccttcatccc gtgtggctct ggaggcagcc      540

acccttggac agtcccgcgc acagctcc                                         568


