
                                SEQUENCE LISTING

<110> KOLLTAN PHARMACEUTICALS, INC
      Yale University

<120> ANTI-ERBB ANTIBODIES AND METHODS OF USE THEREOF

<130> 12638-091-228

<140> PCT/US2015/025311
<141> 2015-04-10

<150> 61/978,783          
<151> 2014-04-11  

<160> 119

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1186
<212> PRT
<213> Homo sapiens

<220> 
<223> an exemplary amino acid sequence of mature human ErbB1 
corresponding to amino acid 25 to 1,210 of Genbank accession 
number NP_005219.2

<400> 1
Leu Glu Glu Lys Lys Val Cys Gln Gly Thr Ser Asn Lys Leu Thr Gln
 1               5                  10                  15      
Leu Gly Thr Phe Glu Asp His Phe Leu Ser Leu Gln Arg Met Phe Asn
            20                  25                  30          
Asn Cys Glu Val Val Leu Gly Asn Leu Glu Ile Thr Tyr Val Gln Arg
        35                  40                  45              
Asn Tyr Asp Leu Ser Phe Leu Lys Thr Ile Gln Glu Val Ala Gly Tyr
    50                  55                  60                  
Val Leu Ile Ala Leu Asn Thr Val Glu Arg Ile Pro Leu Glu Asn Leu
65                  70                  75                  80  
Gln Ile Ile Arg Gly Asn Met Tyr Tyr Glu Asn Ser Tyr Ala Leu Ala
                85                  90                  95      
Val Leu Ser Asn Tyr Asp Ala Asn Lys Thr Gly Leu Lys Glu Leu Pro
            100                 105                 110         
Met Arg Asn Leu Gln Glu Ile Leu His Gly Ala Val Arg Phe Ser Asn
        115                 120                 125             
Asn Pro Ala Leu Cys Asn Val Glu Ser Ile Gln Trp Arg Asp Ile Val
    130                 135                 140                 
Ser Ser Asp Phe Leu Ser Asn Met Ser Met Asp Phe Gln Asn His Leu
145                 150                 155                 160 
Gly Ser Cys Gln Lys Cys Asp Pro Ser Cys Pro Asn Gly Ser Cys Trp
                165                 170                 175     
Gly Ala Gly Glu Glu Asn Cys Gln Lys Leu Thr Lys Ile Ile Cys Ala
            180                 185                 190         
Gln Gln Cys Ser Gly Arg Cys Arg Gly Lys Ser Pro Ser Asp Cys Cys
        195                 200                 205             
His Asn Gln Cys Ala Ala Gly Cys Thr Gly Pro Arg Glu Ser Asp Cys
    210                 215                 220                 
Leu Val Cys Arg Lys Phe Arg Asp Glu Ala Thr Cys Lys Asp Thr Cys
225                 230                 235                 240 
Pro Pro Leu Met Leu Tyr Asn Pro Thr Thr Tyr Gln Met Asp Val Asn
                245                 250                 255     
Pro Glu Gly Lys Tyr Ser Phe Gly Ala Thr Cys Val Lys Lys Cys Pro
            260                 265                 270         
Arg Asn Tyr Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly
        275                 280                 285             
Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys
    290                 295                 300                 
Cys Glu Gly Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu
305                 310                 315                 320 
Phe Lys Asp Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys
                325                 330                 335     
Asn Cys Thr Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe
            340                 345                 350         
Arg Gly Asp Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu
        355                 360                 365             
Asp Ile Leu Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln
    370                 375                 380                 
Ala Trp Pro Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu
385                 390                 395                 400 
Ile Ile Arg Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val
                405                 410                 415     
Val Ser Leu Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile
            420                 425                 430         
Ser Asp Gly Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala
        435                 440                 445             
Asn Thr Ile Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr
    450                 455                 460                 
Lys Ile Ile Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln
465                 470                 475                 480 
Val Cys His Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro
                485                 490                 495     
Arg Asp Cys Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val
            500                 505                 510         
Asp Lys Cys Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn
        515                 520                 525             
Ser Glu Cys Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn
    530                 535                 540                 
Ile Thr Cys Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His
545                 550                 555                 560 
Tyr Ile Asp Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met
                565                 570                 575     
Gly Glu Asn Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val
            580                 585                 590         
Cys His Leu Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly
        595                 600                 605             
Leu Glu Gly Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr
    610                 615                 620                 
Gly Met Val Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile
625                 630                 635                 640 
Gly Leu Phe Met Arg Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg
                645                 650                 655     
Arg Leu Leu Gln Glu Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly
            660                 665                 670         
Glu Ala Pro Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe
        675                 680                 685             
Lys Lys Ile Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys
    690                 695                 700                 
Gly Leu Trp Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile
705                 710                 715                 720 
Lys Glu Leu Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu
                725                 730                 735     
Asp Glu Ala Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys Arg
            740                 745                 750         
Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu
        755                 760                 765             
Met Pro Phe Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn
    770                 775                 780                 
Ile Gly Ser Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly
785                 790                 795                 800 
Met Asn Tyr Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala
                805                 810                 815     
Arg Asn Val Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe
            820                 825                 830         
Gly Leu Ala Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu
        835                 840                 845             
Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His
    850                 855                 860                 
Arg Ile Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val
865                 870                 875                 880 
Trp Glu Leu Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala
                885                 890                 895     
Ser Glu Ile Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro
            900                 905                 910         
Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met
        915                 920                 925             
Ile Asp Ala Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe
    930                 935                 940                 
Ser Lys Met Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp
945                 950                 955                 960 
Glu Arg Met His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala
                965                 970                 975     
Leu Met Asp Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr
            980                 985                 990         
Leu Ile Pro Gln Gln Gly Phe Phe Ser Ser Pro Ser Thr Ser Arg Thr
        995                 1000                1005            
Pro Leu Leu Ser Ser Leu Ser Ala Thr Ser Asn Asn Ser Thr Val Ala
    1010                1015                1020                
Cys Ile Asp Arg Asn Gly Leu Gln Ser Cys Pro Ile Lys Glu Asp Ser
1025                1030                1035                1040
Phe Leu Gln Arg Tyr Ser Ser Asp Pro Thr Gly Ala Leu Thr Glu Asp
                1045                1050                1055    
Ser Ile Asp Asp Thr Phe Leu Pro Val Pro Glu Tyr Ile Asn Gln Ser
            1060                1065                1070        
Val Pro Lys Arg Pro Ala Gly Ser Val Gln Asn Pro Val Tyr His Asn
        1075                1080                1085            
Gln Pro Leu Asn Pro Ala Pro Ser Arg Asp Pro His Tyr Gln Asp Pro
    1090                1095                1100                
His Ser Thr Ala Val Gly Asn Pro Glu Tyr Leu Asn Thr Val Gln Pro
1105                1110                1115                1120
Thr Cys Val Asn Ser Thr Phe Asp Ser Pro Ala His Trp Ala Gln Lys
                1125                1130                1135    
Gly Ser His Gln Ile Ser Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe
            1140                1145                1150        
Phe Pro Lys Glu Ala Lys Pro Asn Gly Ile Phe Lys Gly Ser Thr Ala
        1155                1160                1165            
Glu Asn Ala Glu Tyr Leu Arg Val Ala Pro Gln Ser Ser Glu Phe Ile
    1170                1175                1180                
Gly Ala
1185    


<210> 2
<211> 1323
<212> PRT
<213> Homo sapiens

<220> 
<223> exemplary amino acid sequence of mature human ErbB3, 
corresponding to amino acids 20 to 1,342 of Genbank 
accession number NP_001973.2

<400> 2
Ser Glu Val Gly Asn Ser Gln Ala Val Cys Pro Gly Thr Leu Asn Gly
 1               5                  10                  15      
Leu Ser Val Thr Gly Asp Ala Glu Asn Gln Tyr Gln Thr Leu Tyr Lys
            20                  25                  30          
Leu Tyr Glu Arg Cys Glu Val Val Met Gly Asn Leu Glu Ile Val Leu
        35                  40                  45              
Thr Gly His Asn Ala Asp Leu Ser Phe Leu Gln Trp Ile Arg Glu Val
    50                  55                  60                  
Thr Gly Tyr Val Leu Val Ala Met Asn Glu Phe Ser Thr Leu Pro Leu
65                  70                  75                  80  
Pro Asn Leu Arg Val Val Arg Gly Thr Gln Val Tyr Asp Gly Lys Phe
                85                  90                  95      
Ala Ile Phe Val Met Leu Asn Tyr Asn Thr Asn Ser Ser His Ala Leu
            100                 105                 110         
Arg Gln Leu Arg Leu Thr Gln Leu Thr Glu Ile Leu Ser Gly Gly Val
        115                 120                 125             
Tyr Ile Glu Lys Asn Asp Lys Leu Cys His Met Asp Thr Ile Asp Trp
    130                 135                 140                 
Arg Asp Ile Val Arg Asp Arg Asp Ala Glu Ile Val Val Lys Asp Asn
145                 150                 155                 160 
Gly Arg Ser Cys Pro Pro Cys His Glu Val Cys Lys Gly Arg Cys Trp
                165                 170                 175     
Gly Pro Gly Ser Glu Asp Cys Gln Thr Leu Thr Lys Thr Ile Cys Ala
            180                 185                 190         
Pro Gln Cys Asn Gly His Cys Phe Gly Pro Asn Pro Asn Gln Cys Cys
        195                 200                 205             
His Asp Glu Cys Ala Gly Gly Cys Ser Gly Pro Gln Asp Thr Asp Cys
    210                 215                 220                 
Phe Ala Cys Arg His Phe Asn Asp Ser Gly Ala Cys Val Pro Arg Cys
225                 230                 235                 240 
Pro Gln Pro Leu Val Tyr Asn Lys Leu Thr Phe Gln Leu Glu Pro Asn
                245                 250                 255     
Pro His Thr Lys Tyr Gln Tyr Gly Gly Val Cys Val Ala Ser Cys Pro
            260                 265                 270         
His Asn Phe Val Val Asp Gln Thr Ser Cys Val Arg Ala Cys Pro Pro
        275                 280                 285             
Asp Lys Met Glu Val Asp Lys Asn Gly Leu Lys Met Cys Glu Pro Cys
    290                 295                 300                 
Gly Gly Leu Cys Pro Lys Ala Cys Glu Gly Thr Gly Ser Gly Ser Arg
305                 310                 315                 320 
Phe Gln Thr Val Asp Ser Ser Asn Ile Asp Gly Phe Val Asn Cys Thr
                325                 330                 335     
Lys Ile Leu Gly Asn Leu Asp Phe Leu Ile Thr Gly Leu Asn Gly Asp
            340                 345                 350         
Pro Trp His Lys Ile Pro Ala Leu Asp Pro Glu Lys Leu Asn Val Phe
        355                 360                 365             
Arg Thr Val Arg Glu Ile Thr Gly Tyr Leu Asn Ile Gln Ser Trp Pro
    370                 375                 380                 
Pro His Met His Asn Phe Ser Val Phe Ser Asn Leu Thr Thr Ile Gly
385                 390                 395                 400 
Gly Arg Ser Leu Tyr Asn Arg Gly Phe Ser Leu Leu Ile Met Lys Asn
                405                 410                 415     
Leu Asn Val Thr Ser Leu Gly Phe Arg Ser Leu Lys Glu Ile Ser Ala
            420                 425                 430         
Gly Arg Ile Tyr Ile Ser Ala Asn Arg Gln Leu Cys Tyr His His Ser
        435                 440                 445             
Leu Asn Trp Thr Lys Val Leu Arg Gly Pro Thr Glu Glu Arg Leu Asp
    450                 455                 460                 
Ile Lys His Asn Arg Pro Arg Arg Asp Cys Val Ala Glu Gly Lys Val
465                 470                 475                 480 
Cys Asp Pro Leu Cys Ser Ser Gly Gly Cys Trp Gly Pro Gly Pro Gly
                485                 490                 495     
Gln Cys Leu Ser Cys Arg Asn Tyr Ser Arg Gly Gly Val Cys Val Thr
            500                 505                 510         
His Cys Asn Phe Leu Asn Gly Glu Pro Arg Glu Phe Ala His Glu Ala
        515                 520                 525             
Glu Cys Phe Ser Cys His Pro Glu Cys Gln Pro Met Glu Gly Thr Ala
    530                 535                 540                 
Thr Cys Asn Gly Ser Gly Ser Asp Thr Cys Ala Gln Cys Ala His Phe
545                 550                 555                 560 
Arg Asp Gly Pro His Cys Val Ser Ser Cys Pro His Gly Val Leu Gly
                565                 570                 575     
Ala Lys Gly Pro Ile Tyr Lys Tyr Pro Asp Val Gln Asn Glu Cys Arg
            580                 585                 590         
Pro Cys His Glu Asn Cys Thr Gln Gly Cys Lys Gly Pro Glu Leu Gln
        595                 600                 605             
Asp Cys Leu Gly Gln Thr Leu Val Leu Ile Gly Lys Thr His Leu Thr
    610                 615                 620                 
Met Ala Leu Thr Val Ile Ala Gly Leu Val Val Ile Phe Met Met Leu
625                 630                 635                 640 
Gly Gly Thr Phe Leu Tyr Trp Arg Gly Arg Arg Ile Gln Asn Lys Arg
                645                 650                 655     
Ala Met Arg Arg Tyr Leu Glu Arg Gly Glu Ser Ile Glu Pro Leu Asp
            660                 665                 670         
Pro Ser Glu Lys Ala Asn Lys Val Leu Ala Arg Ile Phe Lys Glu Thr
        675                 680                 685             
Glu Leu Arg Lys Leu Lys Val Leu Gly Ser Gly Val Phe Gly Thr Val
    690                 695                 700                 
His Lys Gly Val Trp Ile Pro Glu Gly Glu Ser Ile Lys Ile Pro Val
705                 710                 715                 720 
Cys Ile Lys Val Ile Glu Asp Lys Ser Gly Arg Gln Ser Phe Gln Ala
                725                 730                 735     
Val Thr Asp His Met Leu Ala Ile Gly Ser Leu Asp His Ala His Ile
            740                 745                 750         
Val Arg Leu Leu Gly Leu Cys Pro Gly Ser Ser Leu Gln Leu Val Thr
        755                 760                 765             
Gln Tyr Leu Pro Leu Gly Ser Leu Leu Asp His Val Arg Gln His Arg
    770                 775                 780                 
Gly Ala Leu Gly Pro Gln Leu Leu Leu Asn Trp Gly Val Gln Ile Ala
785                 790                 795                 800 
Lys Gly Met Tyr Tyr Leu Glu Glu His Gly Met Val His Arg Asn Leu
                805                 810                 815     
Ala Ala Arg Asn Val Leu Leu Lys Ser Pro Ser Gln Val Gln Val Ala
            820                 825                 830         
Asp Phe Gly Val Ala Asp Leu Leu Pro Pro Asp Asp Lys Gln Leu Leu
        835                 840                 845             
Tyr Ser Glu Ala Lys Thr Pro Ile Lys Trp Met Ala Leu Glu Ser Ile
    850                 855                 860                 
His Phe Gly Lys Tyr Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val
865                 870                 875                 880 
Thr Val Trp Glu Leu Met Thr Phe Gly Ala Glu Pro Tyr Ala Gly Leu
                885                 890                 895     
Arg Leu Ala Glu Val Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Ala
            900                 905                 910         
Gln Pro Gln Ile Cys Thr Ile Asp Val Tyr Met Val Met Val Lys Cys
        915                 920                 925             
Trp Met Ile Asp Glu Asn Ile Arg Pro Thr Phe Lys Glu Leu Ala Asn
    930                 935                 940                 
Glu Phe Thr Arg Met Ala Arg Asp Pro Pro Arg Tyr Leu Val Ile Lys
945                 950                 955                 960 
Arg Glu Ser Gly Pro Gly Ile Ala Pro Gly Pro Glu Pro His Gly Leu
                965                 970                 975     
Thr Asn Lys Lys Leu Glu Glu Val Glu Leu Glu Pro Glu Leu Asp Leu
            980                 985                 990         
Asp Leu Asp Leu Glu Ala Glu Glu Asp Asn Leu Ala Thr Thr Thr Leu
        995                 1000                1005            
Gly Ser Ala Leu Ser Leu Pro Val Gly Thr Leu Asn Arg Pro Arg Gly
    1010                1015                1020                
Ser Gln Ser Leu Leu Ser Pro Ser Ser Gly Tyr Met Pro Met Asn Gln
1025                1030                1035                1040
Gly Asn Leu Gly Glu Ser Cys Gln Glu Ser Ala Val Ser Gly Ser Ser
                1045                1050                1055    
Glu Arg Cys Pro Arg Pro Val Ser Leu His Pro Met Pro Arg Gly Cys
            1060                1065                1070        
Leu Ala Ser Glu Ser Ser Glu Gly His Val Thr Gly Ser Glu Ala Glu
        1075                1080                1085            
Leu Gln Glu Lys Val Ser Met Cys Arg Ser Arg Ser Arg Ser Arg Ser
    1090                1095                1100                
Pro Arg Pro Arg Gly Asp Ser Ala Tyr His Ser Gln Arg His Ser Leu
1105                1110                1115                1120
Leu Thr Pro Val Thr Pro Leu Ser Pro Pro Gly Leu Glu Glu Glu Asp
                1125                1130                1135    
Val Asn Gly Tyr Val Met Pro Asp Thr His Leu Lys Gly Thr Pro Ser
            1140                1145                1150        
Ser Arg Glu Gly Thr Leu Ser Ser Val Gly Leu Ser Ser Val Leu Gly
        1155                1160                1165            
Thr Glu Glu Glu Asp Glu Asp Glu Glu Tyr Glu Tyr Met Asn Arg Arg
    1170                1175                1180                
Arg Arg His Ser Pro Pro His Pro Pro Arg Pro Ser Ser Leu Glu Glu
1185                1190                1195                1200
Leu Gly Tyr Glu Tyr Met Asp Val Gly Ser Asp Leu Ser Ala Ser Leu
                1205                1210                1215    
Gly Ser Thr Gln Ser Cys Pro Leu His Pro Val Pro Ile Met Pro Thr
            1220                1225                1230        
Ala Gly Thr Thr Pro Asp Glu Asp Tyr Glu Tyr Met Asn Arg Gln Arg
        1235                1240                1245            
Asp Gly Gly Gly Pro Gly Gly Asp Tyr Ala Ala Met Gly Ala Cys Pro
    1250                1255                1260                
Ala Ser Glu Gln Gly Tyr Glu Glu Met Arg Ala Phe Gln Gly Pro Gly
1265                1270                1275                1280
His Gln Ala Pro His Val His Tyr Ala Arg Leu Lys Thr Leu Arg Ser
                1285                1290                1295    
Leu Glu Ala Thr Asp Ser Ala Phe Asp Asn Pro Asp Tyr Trp His Ser
            1300                1305                1310        
Arg Leu Phe Pro Lys Ala Asn Ala Gln Arg Thr
        1315                1320            


<210> 3
<211> 1283
<212> PRT
<213> Homo sapiens

<220> 
<223> exemplary amino acid sequence of mature human ErbB4 
corresponding to amino acids 26 to 1,308 of Genbank accession
 number NP_005226.1

<400> 3
Gln Ser Val Cys Ala Gly Thr Glu Asn Lys Leu Ser Ser Leu Ser Asp
 1               5                  10                  15      
Leu Glu Gln Gln Tyr Arg Ala Leu Arg Lys Tyr Tyr Glu Asn Cys Glu
            20                  25                  30          
Val Val Met Gly Asn Leu Glu Ile Thr Ser Ile Glu His Asn Arg Asp
        35                  40                  45              
Leu Ser Phe Leu Arg Ser Val Arg Glu Val Thr Gly Tyr Val Leu Val
    50                  55                  60                  
Ala Leu Asn Gln Phe Arg Tyr Leu Pro Leu Glu Asn Leu Arg Ile Ile
65                  70                  75                  80  
Arg Gly Thr Lys Leu Tyr Glu Asp Arg Tyr Ala Leu Ala Ile Phe Leu
                85                  90                  95      
Asn Tyr Arg Lys Asp Gly Asn Phe Gly Leu Gln Glu Leu Gly Leu Lys
            100                 105                 110         
Asn Leu Thr Glu Ile Leu Asn Gly Gly Val Tyr Val Asp Gln Asn Lys
        115                 120                 125             
Phe Leu Cys Tyr Ala Asp Thr Ile His Trp Gln Asp Ile Val Arg Asn
    130                 135                 140                 
Pro Trp Pro Ser Asn Leu Thr Leu Val Ser Thr Asn Gly Ser Ser Gly
145                 150                 155                 160 
Cys Gly Arg Cys His Lys Ser Cys Thr Gly Arg Cys Trp Gly Pro Thr
                165                 170                 175     
Glu Asn His Cys Gln Thr Leu Thr Arg Thr Val Cys Ala Glu Gln Cys
            180                 185                 190         
Asp Gly Arg Cys Tyr Gly Pro Tyr Val Ser Asp Cys Cys His Arg Glu
        195                 200                 205             
Cys Ala Gly Gly Cys Ser Gly Pro Lys Asp Thr Asp Cys Phe Ala Cys
    210                 215                 220                 
Met Asn Phe Asn Asp Ser Gly Ala Cys Val Thr Gln Cys Pro Gln Thr
225                 230                 235                 240 
Phe Val Tyr Asn Pro Thr Thr Phe Gln Leu Glu His Asn Phe Asn Ala
                245                 250                 255     
Lys Tyr Thr Tyr Gly Ala Phe Cys Val Lys Lys Cys Pro His Asn Phe
            260                 265                 270         
Val Val Asp Ser Ser Ser Cys Val Arg Ala Cys Pro Ser Ser Lys Met
        275                 280                 285             
Glu Val Glu Glu Asn Gly Ile Lys Met Cys Lys Pro Cys Thr Asp Ile
    290                 295                 300                 
Cys Pro Lys Ala Cys Asp Gly Ile Gly Thr Gly Ser Leu Met Ser Ala
305                 310                 315                 320 
Gln Thr Val Asp Ser Ser Asn Ile Asp Lys Phe Ile Asn Cys Thr Lys
                325                 330                 335     
Ile Asn Gly Asn Leu Ile Phe Leu Val Thr Gly Ile His Gly Asp Pro
            340                 345                 350         
Tyr Asn Ala Ile Glu Ala Ile Asp Pro Glu Lys Leu Asn Val Phe Arg
        355                 360                 365             
Thr Val Arg Glu Ile Thr Gly Phe Leu Asn Ile Gln Ser Trp Pro Pro
    370                 375                 380                 
Asn Met Thr Asp Phe Ser Val Phe Ser Asn Leu Val Thr Ile Gly Gly
385                 390                 395                 400 
Arg Val Leu Tyr Ser Gly Leu Ser Leu Leu Ile Leu Lys Gln Gln Gly
                405                 410                 415     
Ile Thr Ser Leu Gln Phe Gln Ser Leu Lys Glu Ile Ser Ala Gly Asn
            420                 425                 430         
Ile Tyr Ile Thr Asp Asn Ser Asn Leu Cys Tyr Tyr His Thr Ile Asn
        435                 440                 445             
Trp Thr Thr Leu Phe Ser Thr Ile Asn Gln Arg Ile Val Ile Arg Asp
    450                 455                 460                 
Asn Arg Lys Ala Glu Asn Cys Thr Ala Glu Gly Met Val Cys Asn His
465                 470                 475                 480 
Leu Cys Ser Ser Asp Gly Cys Trp Gly Pro Gly Pro Asp Gln Cys Leu
                485                 490                 495     
Ser Cys Arg Arg Phe Ser Arg Gly Arg Ile Cys Ile Glu Ser Cys Asn
            500                 505                 510         
Leu Tyr Asp Gly Glu Phe Arg Glu Phe Glu Asn Gly Ser Ile Cys Val
        515                 520                 525             
Glu Cys Asp Pro Gln Cys Glu Lys Met Glu Asp Gly Leu Leu Thr Cys
    530                 535                 540                 
His Gly Pro Gly Pro Asp Asn Cys Thr Lys Cys Ser His Phe Lys Asp
545                 550                 555                 560 
Gly Pro Asn Cys Val Glu Lys Cys Pro Asp Gly Leu Gln Gly Ala Asn
                565                 570                 575     
Ser Phe Ile Phe Lys Tyr Ala Asp Pro Asp Arg Glu Cys His Pro Cys
            580                 585                 590         
His Pro Asn Cys Thr Gln Gly Cys Asn Gly Pro Thr Ser His Asp Cys
        595                 600                 605             
Ile Tyr Tyr Pro Trp Thr Gly His Ser Thr Leu Pro Gln His Ala Arg
    610                 615                 620                 
Thr Pro Leu Ile Ala Ala Gly Val Ile Gly Gly Leu Phe Ile Leu Val
625                 630                 635                 640 
Ile Val Gly Leu Thr Phe Ala Val Tyr Val Arg Arg Lys Ser Ile Lys
                645                 650                 655     
Lys Lys Arg Ala Leu Arg Arg Phe Leu Glu Thr Glu Leu Val Glu Pro
            660                 665                 670         
Leu Thr Pro Ser Gly Thr Ala Pro Asn Gln Ala Gln Leu Arg Ile Leu
        675                 680                 685             
Lys Glu Thr Glu Leu Lys Arg Val Lys Val Leu Gly Ser Gly Ala Phe
    690                 695                 700                 
Gly Thr Val Tyr Lys Gly Ile Trp Val Pro Glu Gly Glu Thr Val Lys
705                 710                 715                 720 
Ile Pro Val Ala Ile Lys Ile Leu Asn Glu Thr Thr Gly Pro Lys Ala
                725                 730                 735     
Asn Val Glu Phe Met Asp Glu Ala Leu Ile Met Ala Ser Met Asp His
            740                 745                 750         
Pro His Leu Val Arg Leu Leu Gly Val Cys Leu Ser Pro Thr Ile Gln
        755                 760                 765             
Leu Val Thr Gln Leu Met Pro His Gly Cys Leu Leu Glu Tyr Val His
    770                 775                 780                 
Glu His Lys Asp Asn Ile Gly Ser Gln Leu Leu Leu Asn Trp Cys Val
785                 790                 795                 800 
Gln Ile Ala Lys Gly Met Met Tyr Leu Glu Glu Arg Arg Leu Val His
                805                 810                 815     
Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val
            820                 825                 830         
Lys Ile Thr Asp Phe Gly Leu Ala Arg Leu Leu Glu Gly Asp Glu Lys
        835                 840                 845             
Glu Tyr Asn Ala Asp Gly Gly Lys Met Pro Ile Lys Trp Met Ala Leu
    850                 855                 860                 
Glu Cys Ile His Tyr Arg Lys Phe Thr His Gln Ser Asp Val Trp Ser
865                 870                 875                 880 
Tyr Gly Val Thr Ile Trp Glu Leu Met Thr Phe Gly Gly Lys Pro Tyr
                885                 890                 895     
Asp Gly Ile Pro Thr Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu
            900                 905                 910         
Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Val Met
        915                 920                 925             
Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys Phe Lys Glu
    930                 935                 940                 
Leu Ala Ala Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Tyr Leu
945                 950                 955                 960 
Val Ile Gln Gly Asp Asp Arg Met Lys Leu Pro Ser Pro Asn Asp Ser
                965                 970                 975     
Lys Phe Phe Gln Asn Leu Leu Asp Glu Glu Asp Leu Glu Asp Met Met
            980                 985                 990         
Asp Ala Glu Glu Tyr Leu Val Pro Gln Ala Phe Asn Ile Pro Pro Pro
        995                 1000                1005            
Ile Tyr Thr Ser Arg Ala Arg Ile Asp Ser Asn Arg Ser Glu Ile Gly
    1010                1015                1020                
His Ser Pro Pro Pro Ala Tyr Thr Pro Met Ser Gly Asn Gln Phe Val
1025                1030                1035                1040
Tyr Arg Asp Gly Gly Phe Ala Ala Glu Gln Gly Val Ser Val Pro Tyr
                1045                1050                1055    
Arg Ala Pro Thr Ser Thr Ile Pro Glu Ala Pro Val Ala Gln Gly Ala
            1060                1065                1070        
Thr Ala Glu Ile Phe Asp Asp Ser Cys Cys Asn Gly Thr Leu Arg Lys
        1075                1080                1085            
Pro Val Ala Pro His Val Gln Glu Asp Ser Ser Thr Gln Arg Tyr Ser
    1090                1095                1100                
Ala Asp Pro Thr Val Phe Ala Pro Glu Arg Ser Pro Arg Gly Glu Leu
1105                1110                1115                1120
Asp Glu Glu Gly Tyr Met Thr Pro Met Arg Asp Lys Pro Lys Gln Glu
                1125                1130                1135    
Tyr Leu Asn Pro Val Glu Glu Asn Pro Phe Val Ser Arg Arg Lys Asn
            1140                1145                1150        
Gly Asp Leu Gln Ala Leu Asp Asn Pro Glu Tyr His Asn Ala Ser Asn
        1155                1160                1165            
Gly Pro Pro Lys Ala Glu Asp Glu Tyr Val Asn Glu Pro Leu Tyr Leu
    1170                1175                1180                
Asn Thr Phe Ala Asn Thr Leu Gly Lys Ala Glu Tyr Leu Lys Asn Asn
1185                1190                1195                1200
Ile Leu Ser Met Pro Glu Lys Ala Lys Lys Ala Phe Asp Asn Pro Asp
                1205                1210                1215    
Tyr Trp Asn His Ser Leu Pro Pro Arg Ser Thr Leu Gln His Pro Asp
            1220                1225                1230        
Tyr Leu Gln Glu Tyr Ser Thr Lys Tyr Phe Tyr Lys Gln Asn Gly Arg
        1235                1240                1245            
Ile Arg Pro Ile Val Ala Glu Asn Pro Glu Tyr Leu Ser Glu Phe Ser
    1250                1255                1260                
Leu Lys Pro Gly Thr Val Leu Pro Pro Pro Pro Tyr Arg His Arg Asn
1265                1270                1275                1280
Thr Val Val
            


<210> 4
<211> 118
<212> PRT
<213> Homo sapiens

<220> 
<223> VH domain

<400> 4
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr
            20                  25                  30          
Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Gly Ser Ser Gly Gly Val Thr Asn Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Gly Leu Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ser
        115             


<210> 5
<211> 110
<212> PRT
<213> Homo sapiens

<220> 
<223> VL domain

<400> 5
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Leu Ser Asn Ile Gly Leu Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro
                85                  90                  95      
Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 6
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR1 according to Kabat system

<400> 6
Tyr Tyr Tyr Met Gln
 1               5  


<210> 7
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR2 according to Kabat system

<400> 7
Tyr Ile Gly Ser Ser Gly Gly Val Thr Asn Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR3 according to Kabat system

<400> 8
Val Gly Leu Gly Asp Ala Phe Asp Ile
 1               5                  


<210> 9
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 according to Kabat system

<400> 9
Ser Gly Ser Leu Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR2 according to Kabat system

<400> 10
Arg Asn Asn Gln Arg Pro Ser
 1               5          


<210> 11
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR3 according to Kabat system

<400> 11
Ala Ala Trp Asp Asp Ser Pro Pro Gly Glu Ala
 1               5                  10      


<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR1 according to Chothia system

<400> 12
Gly Phe Thr Phe Ser Tyr Tyr Tyr Met
 1               5                  


<210> 13
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR2 according to Chothia system

<400> 13
Gly Ser Ser Gly Gly
 1               5  


<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR3 according to Chothia system

<400> 14
Val Gly Leu Gly Asp Ala Phe Asp Ile
 1               5                  


<210> 15
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 according to Chothia system

<400> 15
Ser Gly Ser Leu Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 16
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR2 according to Chothia system

<400> 16
Arg Asn Asn Gln Arg Pro Ser
 1               5          


<210> 17
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR3 according to Chothia system

<400> 17
Ala Ala Trp Asp Asp Ser Pro Pro Gly Glu Ala
 1               5                  10      


<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR1 according to IMGT system

<400> 18
Gly Phe Thr Phe Ser Tyr Tyr Tyr
 1               5              


<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR2 according to IMGT system

<400> 19
Ile Gly Ser Ser Gly Gly Val Thr
 1               5              


<210> 20
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR3 according to IMGT system

<400> 20
Ala Arg Val Gly Leu Gly Asp Ala Phe Asp Ile
 1               5                  10      


<210> 21
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR2 according to IMGT system

<400> 21
Leu Ser Asn Ile Gly Leu Asn Tyr
 1               5              


<210> 22
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR3 according to IMGT system

<400> 22
Arg Asn Asn
 1          


<210> 23
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR3 according to IMGT system

<400> 23
Ala Ala Trp Asp Asp Ser Pro Pro Gly Glu Ala
 1               5                  10      


<210> 24
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR2

<220>
<221> VARIANT        
<222> 4
<223> Xaa = Ser or Thr

<220>
<221> VARIANT        
<222> 8
<223> Xaa = Val, Gln, Thr, Ser or Asn

<400> 24
Tyr Ile Gly Xaa Ser Gly Gly Xaa Thr Asn Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 25
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR2

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = Ser or Thr

<400> 25
Gly Xaa Ser Gly Gly
 1               5  


<210> 26
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR2

<220>
<221> VARIANT        
<222> 3
<223> Xaa = Ser or Thr

<220>
<221> VARIANT        
<222> 7
<223> Xaa = Val, Gln, Thr, Ser or Asn

<400> 26
Ile Gly Xaa Ser Gly Gly Xaa Thr
 1               5              


<210> 27
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR3 

<220>
<221> VARIANT        
<222> 3
<223> Xaa = Arg, Gln, Leu, Met, Ile, Trp or Tyr

<400> 27
Val Gly Xaa Gly Asp Ala Phe Asp Ile
 1               5                  


<210> 28
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR3 

<220>
<221> VARIANT        
<222> 3
<223> Xaa = Arg, Gln, Leu, Met, Ile, Trp or Tyr

<400> 28
Val Gly Xaa Gly Asp Ala Phe Asp Ile
 1               5                  


<210> 29
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR3 

<220>
<221> VARIANT        
<222> 5
<223> Xaa = Arg, Gln, Leu, Met, Ile, Trp or Tyr

<400> 29
Ala Arg Val Gly Xaa Gly Asp Ala Phe Asp Ile
 1               5                  10      


<210> 30
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 

<220>
<221> VARIANT        
<222> 1
<223> Xaa = Ser, Asn, Asp, Glu, Gln, His, Arg or Lys

<220>
<221> VARIANT        
<222> 3
<223> Xaa = Ser, Asn, Thr, Asp, Arg, Lys, His, Phe or Tyr

<220>
<221> VARIANT        
<222> 4
<223> Xaa = Leu, Phe, Tyr, Met or Ile

<220>
<221> VARIANT        
<222> 9
<223> Xaa = Leu or Met

<400> 30
Xaa Gly Xaa Xaa Ser Asn Ile Gly Xaa Asn Tyr Val Ser
 1               5                  10              


<210> 31
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1

<220>
<221> VARIANT        
<222> 1
<223> Xaa = Ser, Asn, Asp, Glu, Gln, His, Arg or Lys

<220>
<221> VARIANT        
<222> 3
<223> Xaa = Ser, Asn, Thr, Asp, Arg, Lys, His, Phe or Tyr

<220>
<221> VARIANT        
<222> 4
<223> Xaa = Leu, Phe, Tyr, Met or Ile

<220>
<221> VARIANT        
<222> 9
<223> Xaa = Leu or Met

<400> 31
Xaa Gly Xaa Xaa Ser Asn Ile Gly Xaa Asn Tyr Val Ser
 1               5                  10              


<210> 32
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1

<220>
<221> VARIANT        
<222> 1
<223> Xaa = Leu, Phe, Tyr, Met or Ile

<220>
<221> VARIANT        
<222> 6
<223> Xaa = Leu or Met

<400> 32
Xaa Ser Asn Ile Gly Xaa Asn Tyr
 1               5              


<210> 33
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR3 

<220>
<221> VARIANT        
<222> 5
<223> Xaa = Asp, Asn or His

<400> 33
Ala Ala Trp Asp Xaa Ser Pro Pro Gly Glu Ala
 1               5                  10      


<210> 34
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR3 

<220>
<221> VARIANT        
<222> 5
<223> Xaa = Asp, Asn or His

<400> 34
Ala Ala Trp Asp Xaa Ser Pro Pro Gly Glu Ala
 1               5                  10      


<210> 35
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR3 

<220>
<221> VARIANT        
<222> 5
<223> Xaa = Asp, Asn or His

<400> 35
Ala Ala Trp Asp Xaa Ser Pro Pro Gly Glu Ala
 1               5                  10      


<210> 36
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Kabat system

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Arg, Asn, Asp, Glu, Gln or His

<400> 36
Xaa Gly Ser Leu Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 37
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Chothia system

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Arg, Asn, Asp, Glu, Gln or His

<400> 37
Xaa Gly Ser Leu Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 38
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Kabat system

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = His, Asn, Thr, Asp, Arg, Leu, Phe or Tyr

<400> 38
Ser Gly Xaa Leu Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 39
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Chothia system

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = His, Asn, Thr, Asp, Arg, Leu, Phe or Tyr

<400> 39
Ser Gly Xaa Leu Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 40
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Kabat system

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Ile, Met, Phe or Tyr

<400> 40
Ser Gly Ser Xaa Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 41
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Chothia system

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Ile, Met, Phe or Tyr

<400> 41
Ser Gly Ser Xaa Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 42
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by IMGT system

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Ile, Met, Phe or Tyr

<400> 42
Xaa Ser Asn Ile Gly Leu Asn Tyr
 1               5              


<210> 43
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Kabat system

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Arg, Asn, Glu, Gln, His or Lys

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = His, Asn, Thr, Asp, Arg, Leu, Phe or Tyr

<400> 43
Xaa Gly Xaa Leu Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 44
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Chothia system

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Arg, Asn, Glu, Gln, His or Lys

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = His, Asn, Thr, Asp, Arg, Leu, Phe or Tyr

<400> 44
Xaa Gly Xaa Leu Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 45
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR2 defined by Kabat system

<220>
<221> VARIANT        
<222> 15
<223> Xaa = Gln, Thr, Ser or Asn

<400> 45
Tyr Ile Gly Ser Ser Gly Gly Val Thr Asn Tyr Ala Asp Ser Xaa Lys
 1               5                  10                  15      
Gly
    


<210> 46
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Kabat system

<220>
<221> VARIANT        
<222> 1
<223> Xaa = Arg, Asn, Glu, Gln, His or Lys

<400> 46
Xaa Gly Ser Leu Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 47
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Chothia system

<220>
<221> VARIANT        
<222> 1
<223> Xaa = Arg, Asn, Glu, Gln, His or Lys

<400> 47
Xaa Gly Ser Leu Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 48
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Kabat system

<220>
<221> VARIANT        
<222> 1
<223> Xaa = Arg, Asn, Glu, Gln, His or Lys

<220>
<221> VARIANT        
<222> 4
<223> Xaa = Ile, Met, Phe or Tyr

<400> 48
Xaa Gly Ser Xaa Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 49
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Chothia system

<220>
<221> VARIANT        
<222> 1
<223> Xaa = Arg, Asn, Glu, Gln, His or Lys

<220>
<221> VARIANT        
<222> 4
<223> Xaa = Ile, Met, Phe or Tyr

<400> 49
Xaa Gly Ser Xaa Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 50
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Kabat system

<220>
<221> VARIANT        
<222> 3
<223> Xaa = His, Asn, Thr, Asp, Arg, Leu, Phe or Tyr

<220>
<221> VARIANT        
<222> 4
<223> Xaa = Ile, Met, Phe or Tyr

<400> 50
Ser Gly Xaa Xaa Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 51
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Chothia system

<220>
<221> VARIANT        
<222> 3
<223> Xaa = His, Asn, Thr, Asp, Arg, Leu, Phe or Tyr

<220>
<221> VARIANT        
<222> 4
<223> Xaa = Ile, Met, Phe or Tyr

<400> 51
Ser Gly Xaa Xaa Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 52
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Kabat system

<220>
<221> VARIANT        
<222> 1
<223> Xaa = Arg, Asn, Glu, Gln, His or Lys

<220>
<221> VARIANT        
<222> 3
<223> Xaa = His, Asn, Thr, Asp, Arg, Leu, Phe or Tyr

<400> 52
Xaa Gly Xaa Leu Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 53
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Chothia system

<220>
<221> VARIANT        
<222> 1
<223> Xaa = Arg, Asn, Glu, Gln, His or Lys

<220>
<221> VARIANT        
<222> 3
<223> Xaa = His, Asn, Thr, Asp, Arg, Leu, Phe or Tyr

<400> 53
Xaa Gly Xaa Leu Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 54
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Kabat system

<220>
<221> VARIANT        
<222> 1
<223> Xaa = Arg, Asn, Glu, Gln, His or Lys

<220>
<221> VARIANT        
<222> 3
<223> Xaa = His, Asn, Thr, Asp, Arg, Leu, Phe or Tyr

<220>
<221> VARIANT        
<222> 4
<223> Xaa = Ile, Met, Phe or Tyr

<400> 54
Xaa Gly Xaa Xaa Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 55
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Chothia system

<220>
<221> VARIANT        
<222> 1
<223> Xaa = Arg, Asn, Glu, Gln, His or Lys

<220>
<221> VARIANT        
<222> 3
<223> Xaa = His, Asn, Thr, Asp, Arg, Leu, Phe or Tyr

<220>
<221> VARIANT        
<222> 4
<223> Xaa = Ile, Met, Phe or Tyr

<400> 55
Xaa Gly Xaa Xaa Ser Asn Ile Gly Leu Asn Tyr Val Ser
 1               5                  10              


<210> 56
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR1

<220>
<221> VARIANT        
<222> 1
<223> Xaa = Tyr, Ser, Ala or Gly

<400> 56
Xaa Tyr Tyr Met Gln
 1               5  


<210> 57
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR1

<220>
<221> VARIANT        
<222> 6
<223> Xaa = Tyr, Ser, Ala or Gly

<400> 57
Gly Phe Thr Phe Ser Xaa Tyr Tyr Met
 1               5                  


<210> 58
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR1

<220>
<221> VARIANT        
<222> 6
<223> Xaa = Tyr, Ser, Ala or Gly

<400> 58
Gly Phe Thr Phe Ser Xaa Tyr Tyr
 1               5              


<210> 59
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1

<220>
<221> VARIANT        
<222> 9
<223> Xaa = Leu, Ser, Als, Gly or Val

<400> 59
Ser Gly Ser Leu Ser Asn Ile Gly Xaa Asn Tyr Val Ser
 1               5                  10              


<210> 60
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1

<220>
<221> VARIANT        
<222> 9
<223> Xaa = Leu, Ser, Als, Gly or Val

<400> 60
Ser Gly Ser Leu Ser Asn Ile Gly Xaa Asn Tyr Val Ser
 1               5                  10              


<210> 61
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1

<220>
<221> VARIANT        
<222> 6
<223> Xaa = Leu, Ser, Als, Gly or Val

<400> 61
Leu Ser Asn Ile Gly Xaa Asn Tyr
 1               5              


<210> 62
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR2

<220>
<221> VARIANT        
<222> 1
<223> Xaa = Arg, Phe, Tyr, His, Ala, Leu, Ile or Val

<400> 62
Xaa Asn Asn Gln Arg Pro Ser
 1               5          


<210> 63
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR2

<220>
<221> VARIANT        
<222> 1
<223> Xaa = Arg, Phe, Tyr, His, Ala, Leu, Ile or Val

<400> 63
Xaa Asn Asn Gln Arg Pro Ser
 1               5          


<210> 64
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR2

<220>
<221> VARIANT        
<222> 1
<223> Xaa = Arg, Phe, Tyr, His, Ala, Leu, Ile or Val

<400> 64
Xaa Asn Asn
 1          


<210> 65
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR1 defined by Kabat system

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Ser, Ala or Gly

<400> 65
Xaa Tyr Tyr Met Gln
 1               5  


<210> 66
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR1 defined by Chothia system

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Ser, Ala or Gly

<400> 66
Gly Phe Thr Phe Ser Xaa Tyr Tyr Met
 1               5                  


<210> 67
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH CDR1 defined by IMGT system

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Ser, Ala or Gly

<400> 67
Gly Phe Thr Phe Ser Xaa Tyr Tyr
 1               5              


<210> 68
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Kabat system

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = Ser, Ala, Gly or Val

<400> 68
Ser Gly Ser Leu Ser Asn Ile Gly Xaa Asn Tyr Val Ser
 1               5                  10              


<210> 69
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Chothia system

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = Ser, Ala, Gly or Val

<400> 69
Ser Gly Ser Leu Ser Asn Ile Gly Xaa Asn Tyr Val Ser
 1               5                  10              


<210> 70
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by IMGT system

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Ser, Ala, Gly or Val

<400> 70
Leu Ser Asn Ile Gly Xaa Asn Tyr
 1               5              


<210> 71
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR2 defined by Kabat system

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Phe, Tyr, His, Ala, Leu, Ile or Val

<400> 71
Xaa Asn Asn Gln Arg Pro Ser
 1               5          


<210> 72
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR2 defined by Chothia system

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Phe, Tyr, His, Ala, Leu, Ile or Val

<400> 72
Xaa Asn Asn Gln Arg Pro Ser
 1               5          


<210> 73
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR2 defined by IMGT system

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Phe, Tyr, His, Ala, Leu, Ile or Val

<400> 73
Xaa Asn Asn
 1          


<210> 74
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Kabat system

<220> 
<221> VARIANT        
<222> 11
<223> Xaa = Tyr, Phe, Ile, Val, Leu or Ala

<400> 74
Ser Gly Ser Leu Ser Asn Ile Gly Leu Asn Xaa Val Ser
 1               5                  10              


<210> 75
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by Chothia system

<220> 
<221> VARIANT        
<222> 11
<223> Xaa = Tyr, Phe, Ile, Val, Leu or Ala

<400> 75
Ser Gly Ser Leu Ser Asn Ile Gly Leu Asn Xaa Val Ser
 1               5                  10              


<210> 76
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL CDR1 defined by IMGT system

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = Tyr, Phe, Ile, Val, Leu or Ala

<400> 76
Leu Ser Asn Ile Gly Leu Asn Xaa
 1               5              


<210> 77
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL FR1 defined by Kabat system

<400> 77
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys
            20          


<210> 78
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL FR2 defined by Kabat system

<400> 78
Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Ser
 1               5                  10                  15  


<210> 79
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL FR3 defined by Kabat system

<220> 
<221> VARIANT        
<222> 13
<223> Xaa = Thr, Asn or Tyr

<220> 
<221> VARIANT        
<222> 14
<223> Xaa = Ser, Asn, His, Tyr, Lys or Arg

<400> 79
Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Xaa Xaa Ala Ser
 1               5                  10                  15      
Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys
            20                  25                  30          


<210> 80
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL FR4 defined by Kabat system

<400> 80
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala
 1               5                  10                  15      
Pro Ser Val Thr Leu
            20      


<210> 81
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH FR1 defined by Kabat system

<400> 81
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
            20                  25                  30  


<210> 82
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH FR2 defined by Kabat system

<400> 82
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
 1               5                  10                  


<210> 83
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH FR3 defined by Kabat system

<400> 83
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
 1               5                  10                  15      
Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
            20                  25                  30          


<210> 84
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH FR4 defined by Kabat system

<400> 84
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
 1               5                  10      


<210> 85
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL FR1 defined by Chothia system

<400> 85
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys
            20          


<210> 86
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL FR2 defined by Chothia system

<400> 86
Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Ser
 1               5                  10                  15  


<210> 87
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL FR3 defined by Chothia system

<220> 
<221> VARIANT        
<222> 13
<223> Xaa = Thr, Asn or Tyr

<220> 
<221> VARIANT        
<222> 14
<223> Xaa = Ser, Asn, His, Tyr, Lys or Arg

<400> 87
Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Xaa Xaa Ala Ser
 1               5                  10                  15      
Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys
            20                  25                  30          


<210> 88
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL FR4 defined by Chothia system

<400> 88
Phe Gly Gly Gly Thr Lys Leu Thr Val
 1               5                  


<210> 89
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH FR1 defined by Chothia system

<400> 89
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 90
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH FR2 defined by Chothia system

<400> 90
Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Tyr
 1               5                  10                  15      
Ile
    


<210> 91
<211> 42
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH FR3 defined by Chothia system

<220>
<221> VARIANT        
<222> 8
<223> Xaa = Val, Gln, Thr, Ser or Asn

<400> 91
Val Thr Asn Tyr Ala Asp Ser Xaa Lys Gly Arg Phe Thr Ile Ser Arg
 1               5                  10                  15      
Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
            20                  25                  30          
Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
        35                  40          


<210> 92
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH FR4 defined by Chothia system

<400> 92
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
 1               5                  10      


<210> 93
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL FR1 defined by IMGT system

<220>
<221> VARIANT        
<222> 23
<223> Xaa = Ser, Arg, Asn, Asp, Glu or Gln 

<220>
<221> VARIANT        
<222> 25
<223> Xaa = Ser, His, Asn, Thr, Asp, Arg, Leu, Phe or Tyr

<400> 93
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Xaa Gly Xaa
            20                  25  


<210> 94
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL FR2 defined by IMGT system

<400> 94
Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile
 1               5                  10                  15      
Ser
    


<210> 95
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL FR3 defined by IMGT system

<220> 
<221> VARIANT        
<222> 17
<223> Xaa = Thr, Asn or Tyr

<220> 
<221> VARIANT        
<222> 18
<223> Xaa = Ser, Asn, His, Tyr, Lys or Arg

<400> 95
Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly
 1               5                  10                  15      
Xaa Xaa Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala
            20                  25                  30          
Asp Tyr Tyr Cys
        35      


<210> 96
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL FR4 defined by IMGT system

<400> 96
Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
 1               5                  10  


<210> 97
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH FR1 defined by IMGT system

<400> 97
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser
            20                  25  


<210> 98
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH FR2 defined by IMGT system

<400> 98
Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser
 1               5                  10                  15      
Tyr
    


<210> 99
<211> 38
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH FR3 defined by IMGT system

<220>
<221> VARIANT        
<222> 6
<223> Xaa = Val, Gln, Thr, Ser or Asn

<400> 99
Asn Tyr Ala Asp Ser Xaa Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn
 1               5                  10                  15      
Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
            20                  25                  30          
Thr Ala Val Tyr Tyr Cys
        35              


<210> 100
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH FR4 defined by IMGT system

<400> 100
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser
 1               5                  10      


<210> 101
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain

<220>
<221> VARIANT        
<222> 23
<223> Xaa = Arg, Asn, Asp, Glu, Gln or His

<400> 101
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Xaa Gly Ser Leu Ser Asn Ile Gly Leu Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro
                85                  90                  95      
Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 102
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain

<220>
<221> VARIANT        
<222> 25
<223> Xaa = His, Asn, Thr, Asp, Arg, Leu, Phe or Tyr

<400> 102
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Xaa Leu Ser Asn Ile Gly Leu Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro
                85                  90                  95      
Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 103
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH domain 

<220>
<221> VARIANT        
<222> 64
<223> Xaa = Gln, Thr, Ser or Asn

<400> 103
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Tyr Tyr
            20                  25                  30          
Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Gly Ser Ser Gly Gly Val Thr Asn Tyr Ala Asp Ser Xaa
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Gly Leu Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ser
        115             


<210> 104
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain 

<220>
<221> VARIANT        
<222> 26
<223> Xaa = Ile, Met, Phe or Tyr

<400> 104
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Xaa Ser Asn Ile Gly Leu Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro
                85                  90                  95      
Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 105
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain

<220>
<221> VARIANT        
<222> 23
<223> Xaa = Arg, Asn, Glu, Gln, His or Lys

<220>
<221> VARIANT        
<222> 25
<223> Xaa = His, Asn, Thr, Asp, Arg, Leu, Phe or Tyr

<400> 105
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Xaa Gly Xaa Leu Ser Asn Ile Gly Leu Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro
                85                  90                  95      
Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 106
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain

<220>
<221> VARIANT        
<222> 23
<223> Xaa = Arg, Asn, Glu, Gln, His or Lys

<400> 106
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Xaa Gly Ser Leu Ser Asn Ile Gly Leu Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro
                85                  90                  95      
Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 107
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain

<220>
<221> VARIANT        
<222> 23
<223> Xaa = Arg, Asn, Glu, Gln, His or Lys

<220>
<221> VARIANT        
<222> 26
<223> Xaa = Ile, Met, Phe or Tyr

<400> 107
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Xaa Gly Ser Xaa Ser Asn Ile Gly Leu Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro
                85                  90                  95      
Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 108
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain

<220>
<221> VARIANT        
<222> 25
<223> Xaa = His, Asn, Thr, Asp, Arg, Leu, Phe or Tyr

<220>
<221> VARIANT        
<222> 26
<223> Xaa = Ile, Met, Phe or Tyr

<400> 108
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Xaa Xaa Ser Asn Ile Gly Leu Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro
                85                  90                  95      
Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 109
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain

<220>
<221> VARIANT        
<222> 23
<223> Xaa = Arg, Asn, Asp, Glu, Gln, His or Lys

<220>
<221> VARIANT        
<222> 25
<223> Xaa = His, Asn, Thr, Asp, Arg, Leu, Phe or Tyr

<400> 109
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Xaa Gly Xaa Leu Ser Asn Ile Gly Leu Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro
                85                  90                  95      
Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 110
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain

<220>
<221> VARIANT        
<222> 23
<223> Xaa = Arg, Asn, Asp, Glu, Gln, His or Lys

<220>
<221> VARIANT        
<222> 25
<223> Xaa = His, Asn, Thr, Asp, Arg, Leu, Phe or Tyr

<220>
<221> VARIANT        
<222> 26
<223> Xaa = Ile, Met, Phe or Tyr

<400> 110
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Xaa Gly Xaa Xaa Ser Asn Ile Gly Leu Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro
                85                  90                  95      
Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 111
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH domain

<220> 
<221> VARIANT        
<222> 31
<223> Xaa = Ser, Ala or Gly

<400> 111
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Xaa Tyr
            20                  25                  30          
Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Gly Ser Ser Gly Gly Val Thr Asn Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Gly Leu Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ser
        115             


<210> 112
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain

<220>
<221> VARIANT        
<222> 70
<223> Xaa = Asn, His, Tyr, Lys or Arg

<220>
<221> VARIANT        
<222> 71
<223> Xaa = Asn or Tyr

<400> 112
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Leu Ser Asn Ile Gly Leu Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Xaa Xaa Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro
                85                  90                  95      
Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 113
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain

<220> 
<221> VARIANT        
<222> 51
<223> Xaa = Phe, Tyr, His, Ala, Leu, Ile or Val

<400> 113
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Leu Ser Asn Ile Gly Leu Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Ser Xaa Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro
                85                  90                  95      
Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 114
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain

<220> 
<221> VARIANT        
<222> 31
<223> Xaa = Ser, Ala, Gly or Val

<220> 
<221> VARIANT        
<222> 51
<223> Xaa = Phe, Tyr, His, Ala, Leu, Ile or Val

<400> 114
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Leu Ser Asn Ile Gly Xaa Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Ser Xaa Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro
                85                  90                  95      
Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 115
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain

<220> 
<221> VARIANT        
<222> 31
<223> Xaa = Ser, Ala, Gly or Val

<400> 115
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Leu Ser Asn Ile Gly Xaa Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro
                85                  90                  95      
Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 116
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> VH domain

<220> 
<221> VARIANT        
<222> 31
<223> Xaa = Ser, Ala, Gly or Val

<400> 116
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Xaa Tyr
            20                  25                  30          
Tyr Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Tyr Ile Gly Ser Ser Gly Gly Val Thr Asn Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Gly Leu Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr
            100                 105                 110         
Met Val Thr Val Ser Ser
        115             


<210> 117
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL domain

<220>
<221> VARIANT        
<222> 33
<223> Xaa = Tyr, Phe, Ile, Val, Leu or Ala

<400> 117
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Leu Ser Asn Ile Gly Leu Asn
            20                  25                  30          
Xaa Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro
                85                  90                  95      
Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 118
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> VL region

<220>
<221> VARIANT        
<222> 70
<223> Xaa = Thr, Asn or Tyr

<220>
<221> VARIANT        
<222> 71
<223> Xaa = Ser, Asn, His, Tyr, Lys or Arg

<400> 118
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Leu Ser Asn Ile Gly Leu Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Ser Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Xaa Xaa Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Pro
                85                  90                  95      
Pro Gly Glu Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 119
<211> 645
<212> PRT
<213> Homo sapiens

<220> 
<223> human neuregulin-1-beta1

<400> 119
Met Ser Glu Arg Lys Glu Gly Arg Gly Lys Gly Lys Gly Lys Lys Lys
 1               5                  10                  15      
Glu Arg Gly Ser Gly Lys Lys Pro Glu Ser Ala Ala Gly Ser Gln Ser
            20                  25                  30          
Pro Ala Leu Pro Pro Arg Leu Lys Glu Met Lys Ser Gln Glu Ser Ala
        35                  40                  45              
Ala Gly Ser Lys Leu Val Leu Arg Cys Glu Thr Ser Ser Glu Tyr Ser
    50                  55                  60                  
Ser Leu Arg Phe Lys Trp Phe Lys Asn Gly Asn Glu Leu Asn Arg Lys
65                  70                  75                  80  
Asn Lys Pro Gln Asn Ile Lys Ile Gln Lys Lys Pro Gly Lys Ser Glu
                85                  90                  95      
Leu Arg Ile Asn Lys Ala Ser Leu Ala Asp Ser Gly Glu Tyr Met Cys
            100                 105                 110         
Lys Val Ile Ser Lys Leu Gly Asn Asp Ser Ala Ser Ala Asn Ile Thr
        115                 120                 125             
Ile Val Glu Ser Asn Glu Ile Ile Thr Gly Met Pro Ala Ser Thr Glu
    130                 135                 140                 
Gly Ala Tyr Val Ser Ser Glu Ser Pro Ile Arg Ile Ser Val Ser Thr
145                 150                 155                 160 
Glu Gly Ala Asn Thr Ser Ser Ser Thr Ser Thr Ser Thr Thr Gly Thr
                165                 170                 175     
Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn
            180                 185                 190         
Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr
        195                 200                 205             
Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr
    210                 215                 220                 
Val Met Ala Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met Glu Ala
225                 230                 235                 240 
Glu Glu Leu Tyr Gln Lys Arg Val Leu Thr Ile Thr Gly Ile Cys Ile
                245                 250                 255     
Ala Leu Leu Val Val Gly Ile Met Cys Val Val Ala Tyr Cys Lys Thr
            260                 265                 270         
Lys Lys Gln Arg Lys Lys Leu His Asp Arg Leu Arg Gln Ser Leu Arg
        275                 280                 285             
Ser Glu Arg Asn Asn Met Met Asn Ile Ala Asn Gly Pro His His Pro
    290                 295                 300                 
Asn Pro Pro Pro Glu Asn Val Gln Leu Val Asn Gln Tyr Val Ser Lys
305                 310                 315                 320 
Asn Val Ile Ser Ser Glu His Ile Val Glu Arg Glu Ala Glu Thr Ser
                325                 330                 335     
Phe Ser Thr Ser His Tyr Thr Ser Thr Ala His His Ser Thr Thr Val
            340                 345                 350         
Thr Gln Thr Pro Ser His Ser Trp Ser Asn Gly His Thr Glu Ser Ile
        355                 360                 365             
Leu Ser Glu Ser His Ser Val Ile Val Met Ser Ser Val Glu Asn Ser
    370                 375                 380                 
Arg His Ser Ser Pro Thr Gly Gly Pro Arg Gly Arg Leu Asn Gly Thr
385                 390                 395                 400 
Gly Gly Pro Arg Glu Cys Asn Ser Phe Leu Arg His Ala Arg Glu Thr
                405                 410                 415     
Pro Asp Ser Tyr Arg Asp Ser Pro His Ser Glu Arg Tyr Val Ser Ala
            420                 425                 430         
Met Thr Thr Pro Ala Arg Met Ser Pro Val Asp Phe His Thr Pro Ser
        435                 440                 445             
Ser Pro Lys Ser Pro Pro Ser Glu Met Ser Pro Pro Val Ser Ser Met
    450                 455                 460                 
Thr Val Ser Met Pro Ser Met Ala Val Ser Pro Phe Met Glu Glu Glu
465                 470                 475                 480 
Arg Pro Leu Leu Leu Val Thr Pro Pro Arg Leu Arg Glu Lys Lys Phe
                485                 490                 495     
Asp His His Pro Gln Gln Phe Ser Ser Phe His His Asn Pro Ala His
            500                 505                 510         
Asp Ser Asn Ser Leu Pro Ala Ser Pro Leu Arg Ile Val Glu Asp Glu
        515                 520                 525             
Glu Tyr Glu Thr Thr Gln Glu Tyr Glu Pro Ala Gln Glu Pro Val Lys
    530                 535                 540                 
Lys Leu Ala Asn Ser Arg Arg Ala Lys Arg Thr Lys Pro Asn Gly His
545                 550                 555                 560 
Ile Ala Asn Arg Leu Glu Val Asp Ser Asn Thr Ser Ser Gln Ser Ser
                565                 570                 575     
Asn Ser Glu Ser Glu Thr Glu Asp Glu Arg Val Gly Glu Asp Thr Pro
            580                 585                 590         
Phe Leu Gly Ile Gln Asn Pro Leu Ala Ala Ser Leu Glu Ala Thr Pro
        595                 600                 605             
Ala Phe Arg Leu Ala Asp Ser Arg Thr Asn Pro Ala Gly Arg Phe Ser
    610                 615                 620                 
Thr Gln Glu Glu Ile Gln Ala Arg Leu Ser Ser Val Ile Ala Asn Gln
625                 630                 635                 640 
Asp Pro Ile Ala Val
                645 

