                               SEQUENCE LISTING

<110> MEDIMMUNE, LLC
 
<120> CONJUGATED COMPOUNDS COMPRISING CYSTEINE-ENGINEERED ANTIBODIES

<130> CYS-115WO1

<140> PCT/US2015/025237
<141> 2015-04-10

<150> 61/978,481
<151> 2014-04-11

<160> 18    

<170> PatentIn version 3.5

<210> 1
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 1
His His His His His His 
1               5       


<210> 2
<211> 250
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<220>
<221> MISC_FEATURE
<222> (1)..(4)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (5)..(5)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (6)..(9)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (10)..(10)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (11)..(14)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (15)..(15)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (16)..(19)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (20)..(20)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (21)..(24)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (25)..(25)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (26)..(29)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (30)..(30)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (31)..(34)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (35)..(35)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (36)..(39)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (40)..(40)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (41)..(44)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (45)..(45)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (46)..(49)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (50)..(50)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (51)..(54)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (55)..(55)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (56)..(59)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (60)..(60)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (61)..(64)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (65)..(65)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (66)..(69)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (70)..(70)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (71)..(74)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (75)..(75)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (76)..(79)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (80)..(80)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (81)..(84)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (85)..(85)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (86)..(89)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (90)..(90)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (91)..(94)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (95)..(95)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (96)..(99)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (100)..(100)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (101)..(104)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (105)..(105)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (106)..(109)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (110)..(110)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (111)..(114)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (115)..(115)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (116)..(119)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (120)..(120)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (121)..(124)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (125)..(125)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (126)..(129)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (130)..(130)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (131)..(134)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (135)..(135)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (136)..(139)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (140)..(140)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (141)..(144)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (145)..(145)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (146)..(149)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (150)..(150)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (151)..(154)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (155)..(155)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (156)..(159)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (160)..(160)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (161)..(164)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (165)..(165)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (166)..(169)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (170)..(170)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (171)..(174)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (175)..(175)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (176)..(179)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (180)..(180)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (181)..(184)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (185)..(185)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (186)..(189)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (190)..(190)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (191)..(194)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (195)..(195)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (196)..(199)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (200)..(200)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (201)..(204)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (205)..(205)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (206)..(209)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (210)..(210)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (211)..(214)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (215)..(215)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (216)..(219)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (220)..(220)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (221)..(224)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (225)..(225)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (226)..(229)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (230)..(230)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (231)..(234)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (235)..(235)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (236)..(239)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (240)..(240)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (241)..(244)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (245)..(245)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (246)..(249)
<223> This region may encompass 1-4 residues, wherein some 
      positions may be absent 

<220>
<221> MISC_FEATURE
<222> (250)..(250)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (1)..(250)
<223> This sequence may encompass 1-50 "(Gly)x-(Ser)y"
      repeating units, where x is from 1 to 4, y is 0 or 1 

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 2
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                165                 170                 175     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            180                 185                 190         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        195                 200                 205             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    210                 215                 220                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250 


<210> 3
<211> 100
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(100) 
<223> This sequence may encompass 1-100 residues, wherein some
      positions may be absent

<400> 3
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Gly Gly 
            100 


<210> 4
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Gly Gly Gly Gly 
1               


<210> 5
<211> 200
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(200) 
<223> This sequence may encompass 1-100 "Gly Ala" repeating 
      units, wherein some positions may be absent

<400> 5
Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
1               5                   10                  15      


Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
            20                  25                  30          


Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
        35                  40                  45              


Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
    50                  55                  60                  


Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
65                  70                  75                  80  


Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
                85                  90                  95      


Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
            100                 105                 110         


Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
        115                 120                 125             


Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
    130                 135                 140                 


Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
145                 150                 155                 160 


Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
                165                 170                 175     


Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala Gly Ala 
            180                 185                 190         


Gly Ala Gly Ala Gly Ala Gly Ala 
        195                 200 


<210> 6
<211> 300
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(300) 
<223> This sequence may encompass 1-100 "Gly Gly Ser" repeating 
      units, wherein some positions may be absent

<400> 6
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        35                  40                  45              


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    50                  55                  60                  


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
65                  70                  75                  80  


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                85                  90                  95      


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
            100                 105                 110         


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    130                 135                 140                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                165                 170                 175     


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            180                 185                 190         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        195                 200                 205             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    210                 215                 220                 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
                245                 250                 255     


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            260                 265                 270         


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        275                 280                 285             


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    290                 295                 300 


<210> 7
<211> 400
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(400) 
<223> This sequence may encompass 1-100 "Gly Gly Gly Ser" repeating 
      units, wherein some positions may be absent

<400> 7
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    50                  55                  60                  


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
                85                  90                  95      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
145                 150                 155                 160 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
                165                 170                 175     


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            180                 185                 190         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        195                 200                 205             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    210                 215                 220                 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        275                 280                 285             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
                325                 330                 335     


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
        355                 360                 365             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
385                 390                 395                 400 


<210> 8
<211> 800
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(300) 
<223> This region may encompass 1-100 "Gly Gly Ser" repeating 
      units, wherein some positions may be absent

<220>
<221> MISC_FEATURE
<222> (301)..(800) 
<223> This region may encompass 1-100 "Gly Gly Gly Gly Ser" 
      repeating units, wherein some positions may be absent

<400> 8
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            20                  25                  30          


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        35                  40                  45              


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
    50                  55                  60                  


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
65                  70                  75                  80  


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
                85                  90                  95      


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
            100                 105                 110         


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
        115                 120                 125             


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
    130                 135                 140                 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
145                 150                 155                 160 


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                165                 170                 175     


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            180                 185                 190         


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
        195                 200                 205             


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
    210                 215                 220                 


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
                245                 250                 255     


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
            260                 265                 270         


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
        275                 280                 285             


Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly 
    290                 295                 300                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
305                 310                 315                 320 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                325                 330                 335     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            340                 345                 350         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            420                 425                 430         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        435                 440                 445             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    450                 455                 460                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                485                 490                 495     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            500                 505                 510         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        515                 520                 525             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    530                 535                 540                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
545                 550                 555                 560 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                565                 570                 575     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            580                 585                 590         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        595                 600                 605             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    610                 615                 620                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
625                 630                 635                 640 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                645                 650                 655     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            660                 665                 670         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        675                 680                 685             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    690                 695                 700                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
705                 710                 715                 720 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                725                 730                 735     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            740                 745                 750         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        755                 760                 765             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    770                 775                 780                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
785                 790                 795                 800 


<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Ser Gly Gly Ser Gly Gly Ser 
1               5           


<210> 10
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Gly 
1               5                   10                  15  


<210> 11
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Gly Gly Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210> 12
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser 
        


<210> 13
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 14
<211> 400
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(400) 
<223> This sequence may encompass 1-100 "Gly Gly Gly Gly" repeating 
      units, wherein some positions may be absent

<400> 14
Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            20                  25                  30          


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    50                  55                  60                  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
65                  70                  75                  80  


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
                85                  90                  95      


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            100                 105                 110         


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        115                 120                 125             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    130                 135                 140                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
145                 150                 155                 160 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
                165                 170                 175     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            180                 185                 190         


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        195                 200                 205             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
225                 230                 235                 240 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            260                 265                 270         


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        275                 280                 285             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    290                 295                 300                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
305                 310                 315                 320 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
                325                 330                 335     


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
            340                 345                 350         


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        355                 360                 365             


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    370                 375                 380                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
385                 390                 395                 400 


<210> 15
<211> 217
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210> 16
<211> 216
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
            100                 105                 110         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        115                 120                 125             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    130                 135                 140                 


Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
145                 150                 155                 160 


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                165                 170                 175     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            180                 185                 190         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        195                 200                 205             


Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215     


<210> 17
<211> 217
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210> 18
<211> 217
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215         


