                         SEQUENCE LISTING

<110>  Doudna, Jennifer A
       Kaya, Emine
       Knoll, Kilian R
 
<120>  METHODS AND COMPOSITIONS FOR USING ARGONAUTE TO MODIFY A SINGLE 
       STRANDED TARGET NUCLEIC ACID

<130>  BERK-239WO

<150>  US 61/977,931
<151>  2014-04-10

<160>  30    

<170>  PatentIn version 3.5

<210>  1
<211>  639
<212>  PRT
<213>  Marinitoga piezophila

<400>  1

Met Tyr Leu Asn Leu Tyr Lys Ile Asp Ile Pro Lys Lys Ile Lys Arg 
1               5                   10                  15      


Leu Tyr Phe Tyr Asn Pro Asp Met Glu Pro Lys Leu Phe Ala Arg Asn 
            20                  25                  30          


Leu Ser Arg Val Asn Asn Phe Lys Phe Gln Asp Ser Asn Asp Leu Val 
        35                  40                  45              


Trp Ile Glu Ile Pro Asp Ile Asp Phe Gln Ile Thr Pro Lys Asn Val 
    50                  55                  60                  


Phe Gln Tyr Lys Val Glu Lys Glu Glu Ile Ile Lys Glu Glu Glu Asp 
65                  70                  75                  80  


Lys Lys Leu Phe Val Lys Thr Leu Tyr Lys Tyr Ile Lys Lys Leu Phe 
                85                  90                  95      


Leu Asp Asn Asp Phe Tyr Phe Lys Lys Gly Asn Asn Phe Ile Ser Asn 
            100                 105                 110         


Ser Glu Val Phe Ser Leu Asp Ser Asn Glu Asn Val Asn Ala His Leu 
        115                 120                 125             


Thr Tyr Lys Ile Lys Ile His Asn Ile Ser Asn Glu Tyr Tyr Leu Ser 
    130                 135                 140                 


Ile Leu Pro Lys Phe Thr Phe Leu Ser Lys Glu Pro Ala Leu Glu Ser 
145                 150                 155                 160 


Ala Ile Lys Ser Gly Tyr Leu Tyr Asn Ile Lys Ser Gly Lys Ser Phe 
                165                 170                 175     


Pro Tyr Ile Ser Gly Leu Asp Gly Ile Leu Lys Ile Asp Ile Gly Asn 
            180                 185                 190         


Asn Gln Ile Val Glu Val Ala Tyr Pro Glu Asn Tyr Leu Phe Asn Phe 
        195                 200                 205             


Thr Thr Arg Asp Ala Glu Lys Tyr Gly Phe Ser Lys Glu Val His Glu 
    210                 215                 220                 


Ile Tyr Lys Asn Lys Val Phe Glu Gly Phe Lys Lys Ile Pro Lys Thr 
225                 230                 235                 240 


Leu Gly Phe Leu Asn Lys Ile Thr Asn Leu Asn Glu Asn Tyr Gln Leu 
                245                 250                 255     


Lys Asp Gly Tyr Lys Ile Phe Ile Asn Val Ile Tyr Lys Phe Lys Asn 
            260                 265                 270         


Gly Glu Ser Arg Tyr Ala Lys Asp Val Phe Lys Tyr Ser Phe Tyr Lys 
        275                 280                 285             


Asn Glu Gln Pro Leu Lys Ala Ile Phe Phe Phe Ser Ser Lys Lys Gln 
    290                 295                 300                 


Phe Phe Glu Val Gln Lys Ser Leu Lys Glu Leu Phe His Asn Lys His 
305                 310                 315                 320 


Ser Val Phe Tyr Arg Ala Ala Ala Glu Leu Gly Phe Ser Lys Val Glu 
                325                 330                 335     


Phe Leu Arg Asp Ser Lys Thr Lys Ser Ser Ala Phe Leu Tyr Asn Pro 
            340                 345                 350         


Glu Glu Phe Thr Val Lys Asn Thr Glu Phe Ile Asn Gln Ile Glu Asp 
        355                 360                 365             


Asn Val Met Ala Ile Val Leu Leu Asp Lys Tyr Ile Gly Asn Ile Asp 
    370                 375                 380                 


Pro Leu Val Arg Asn Phe Pro Asp Asn Leu Ile Leu Gln Pro Ile Leu 
385                 390                 395                 400 


Lys Glu Lys Leu Glu Asp Ile Lys Pro Phe Ile Ile Lys Ser Tyr Val 
                405                 410                 415     


Tyr Lys Met Gly Asn Phe Ile Pro Glu Cys Lys Pro Phe Ile Leu Lys 
            420                 425                 430         


Lys Met Glu Asp Lys Glu Lys Asn Leu Tyr Ile Gly Ile Asp Leu Ser 
        435                 440                 445             


His Asp Thr Tyr Ala Arg Lys Thr Asn Leu Cys Ile Ala Ala Val Asp 
    450                 455                 460                 


Asn Thr Gly Asp Ile Leu Tyr Ile Gly Lys His Lys Asn Leu Glu Leu 
465                 470                 475                 480 


Asn Glu Lys Met Asn Leu Asp Ile Leu Glu Lys Glu Tyr Ile Lys Ala 
                485                 490                 495     


Phe Glu Lys Tyr Ile Glu Lys Phe Asn Val Ser Pro Glu Asn Val Phe 
            500                 505                 510         


Ile Leu Arg Asp Gly Arg Phe Ile Glu Asp Ile Glu Ile Ile Lys Asn 
        515                 520                 525             


Phe Ile Ser Tyr Asn Asp Thr Lys Tyr Thr Leu Val Glu Val Asn Lys 
    530                 535                 540                 


Asn Thr Asn Ile Asn Ser Tyr Asp Asp Leu Lys Glu Trp Ile Ile Lys 
545                 550                 555                 560 


Leu Asp Glu Asn Thr Tyr Ile Tyr Tyr Pro Lys Thr Phe Leu Asn Gln 
                565                 570                 575     


Lys Gly Val Glu Val Lys Ile Leu Glu Asn Asn Thr Asp Tyr Thr Ile 
            580                 585                 590         


Glu Glu Ile Ile Glu Gln Ile Tyr Leu Leu Thr Arg Val Ala His Ser 
        595                 600                 605             


Thr Pro Tyr Thr Asn Tyr Lys Leu Pro Tyr Pro Leu His Ile Ala Asn 
    610                 615                 620                 


Lys Val Ala Leu Thr Asp Tyr Glu Trp Lys Leu Tyr Ile Pro Tyr 
625                 630                 635                 


<210>  2
<211>  109
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  2

Met Tyr Leu Asn Leu Tyr Lys Ile Asp Ile Pro Lys Lys Ile Lys Arg 
1               5                   10                  15      


Leu Tyr Phe Tyr Asn Pro Asp Met Glu Pro Lys Leu Phe Ala Arg Asn 
            20                  25                  30          


Leu Ser Arg Val Asn Asn Phe Lys Phe Gln Asp Ser Asn Asp Leu Val 
        35                  40                  45              


Trp Ile Glu Ile Pro Asp Ile Asp Phe Gln Ile Thr Pro Lys Asn Val 
    50                  55                  60                  


Phe Gln Tyr Lys Val Glu Lys Glu Glu Ile Ile Lys Glu Glu Glu Asp 
65                  70                  75                  80  


Lys Lys Leu Phe Val Lys Thr Leu Tyr Lys Tyr Ile Lys Lys Leu Phe 
                85                  90                  95      


Leu Asp Asn Asp Phe Tyr Phe Lys Lys Gly Asn Asn Phe 
            100                 105                 


<210>  3
<211>  43
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  3

Ile Ser Asn Ser Glu Val Phe Ser Leu Asp Ser Asn Glu Asn Val Asn 
1               5                   10                  15      


Ala His Leu Thr Tyr Lys Ile Lys Ile His Asn Ile Ser Asn Glu Tyr 
            20                  25                  30          


Tyr Leu Ser Ile Leu Pro Lys Phe Thr Phe Leu 
        35                  40              


<210>  4
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  4

Ser Lys Glu Pro Ala Leu Glu Ser Ala Ile Lys Ser Gly Tyr Leu Tyr 
1               5                   10                  15      


Asn Ile Lys Ser Gly Lys Ser Phe Pro Tyr Ile Ser Gly Leu Asp Gly 
            20                  25                  30          


Ile Leu Lys Ile Asp Ile Gly Asn Asn Gln Ile Val Glu Val Ala Tyr 
        35                  40                  45              


Pro Glu Asn Tyr Leu Phe Asn Phe Thr Thr Arg Asp 
    50                  55                  60  


<210>  5
<211>  69
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  5

Ala Glu Lys Tyr Gly Phe Ser Lys Glu Val His Glu Ile Tyr Lys Asn 
1               5                   10                  15      


Lys Val Phe Glu Gly Phe Lys Lys Ile Pro Lys Thr Leu Gly Phe Leu 
            20                  25                  30          


Asn Lys Ile Thr Asn Leu Asn Glu Asn Tyr Gln Leu Lys Asp Gly Tyr 
        35                  40                  45              


Lys Ile Phe Ile Asn Val Ile Tyr Lys Phe Lys Asn Gly Glu Ser Arg 
    50                  55                  60                  


Tyr Ala Lys Asp Val 
65                  


<210>  6
<211>  149
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  6

Phe Lys Tyr Ser Phe Tyr Lys Asn Glu Gln Pro Leu Lys Ala Ile Phe 
1               5                   10                  15      


Phe Phe Ser Ser Lys Lys Gln Phe Phe Glu Val Gln Lys Ser Leu Lys 
            20                  25                  30          


Glu Leu Phe His Asn Lys His Ser Val Phe Tyr Arg Ala Ala Ala Glu 
        35                  40                  45              


Leu Gly Phe Ser Lys Val Glu Phe Leu Arg Asp Ser Lys Thr Lys Ser 
    50                  55                  60                  


Ser Ala Phe Leu Tyr Asn Pro Glu Glu Phe Thr Val Lys Asn Thr Glu 
65                  70                  75                  80  


Phe Ile Asn Gln Ile Glu Asp Asn Val Met Ala Ile Val Leu Leu Asp 
                85                  90                  95      


Lys Tyr Ile Gly Asn Ile Asp Pro Leu Val Arg Asn Phe Pro Asp Asn 
            100                 105                 110         


Leu Ile Leu Gln Pro Ile Leu Lys Glu Lys Leu Glu Asp Ile Lys Pro 
        115                 120                 125             


Phe Ile Ile Lys Ser Tyr Val Tyr Lys Met Gly Asn Phe Ile Pro Glu 
    130                 135                 140                 


Cys Lys Pro Phe Ile 
145                 


<210>  7
<211>  209
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  7

Leu Lys Lys Met Glu Asp Lys Glu Lys Asn Leu Tyr Ile Gly Ile Asp 
1               5                   10                  15      


Leu Ser His Asp Thr Tyr Ala Arg Lys Thr Asn Leu Cys Ile Ala Ala 
            20                  25                  30          


Val Asp Asn Thr Gly Asp Ile Leu Tyr Ile Gly Lys His Lys Asn Leu 
        35                  40                  45              


Glu Leu Asn Glu Lys Met Asn Leu Asp Ile Leu Glu Lys Glu Tyr Ile 
    50                  55                  60                  


Lys Ala Phe Glu Lys Tyr Ile Glu Lys Phe Asn Val Ser Pro Glu Asn 
65                  70                  75                  80  


Val Phe Ile Leu Arg Asp Gly Arg Phe Ile Glu Asp Ile Glu Ile Ile 
                85                  90                  95      


Lys Asn Phe Ile Ser Tyr Asn Asp Thr Lys Tyr Thr Leu Val Glu Val 
            100                 105                 110         


Asn Lys Asn Thr Asn Ile Asn Ser Tyr Asp Asp Leu Lys Glu Trp Ile 
        115                 120                 125             


Ile Lys Leu Asp Glu Asn Thr Tyr Ile Tyr Tyr Pro Lys Thr Phe Leu 
    130                 135                 140                 


Asn Gln Lys Gly Val Glu Val Lys Ile Leu Glu Asn Asn Thr Asp Tyr 
145                 150                 155                 160 


Thr Ile Glu Glu Ile Ile Glu Gln Ile Tyr Leu Leu Thr Arg Val Ala 
                165                 170                 175     


His Ser Thr Pro Tyr Thr Asn Tyr Lys Leu Pro Tyr Pro Leu His Ile 
            180                 185                 190         


Ala Asn Lys Val Ala Leu Thr Asp Tyr Glu Trp Lys Leu Tyr Ile Pro 
        195                 200                 205             


Tyr 
    


<210>  8
<211>  770
<212>  PRT
<213>  Pyrococcus furiosus

<400>  8

Met Lys Ala Ile Val Val Ile Asn Leu Val Lys Ile Asn Lys Lys Ile 
1               5                   10                  15      


Ile Pro Asp Lys Ile Tyr Val Tyr Arg Leu Phe Asn Asp Pro Glu Glu 
            20                  25                  30          


Glu Leu Gln Lys Glu Gly Tyr Ser Ile Tyr Arg Leu Ala Tyr Glu Asn 
        35                  40                  45              


Val Gly Ile Val Ile Asp Pro Glu Asn Leu Ile Ile Ala Thr Thr Lys 
    50                  55                  60                  


Glu Leu Glu Tyr Glu Gly Glu Phe Ile Pro Glu Gly Glu Ile Ser Phe 
65                  70                  75                  80  


Ser Glu Leu Arg Asn Asp Tyr Gln Ser Lys Leu Val Leu Arg Leu Leu 
                85                  90                  95      


Lys Glu Asn Gly Ile Gly Glu Tyr Glu Leu Ser Lys Leu Leu Arg Lys 
            100                 105                 110         


Phe Arg Lys Pro Lys Thr Phe Gly Asp Tyr Lys Val Ile Pro Ser Val 
        115                 120                 125             


Glu Met Ser Val Ile Lys His Asp Glu Asp Phe Tyr Leu Val Ile His 
    130                 135                 140                 


Ile Ile His Gln Ile Gln Ser Met Lys Thr Leu Trp Glu Leu Val Asn 
145                 150                 155                 160 


Lys Asp Pro Lys Glu Leu Glu Glu Phe Leu Met Thr His Lys Glu Asn 
                165                 170                 175     


Leu Met Leu Lys Asp Ile Ala Ser Pro Leu Lys Thr Val Tyr Lys Pro 
            180                 185                 190         


Cys Phe Glu Glu Tyr Thr Lys Lys Pro Lys Leu Asp His Asn Gln Glu 
        195                 200                 205             


Ile Val Lys Tyr Trp Tyr Asn Tyr His Ile Glu Arg Tyr Trp Asn Thr 
    210                 215                 220                 


Pro Glu Ala Lys Leu Glu Phe Tyr Arg Lys Phe Gly Gln Val Asp Leu 
225                 230                 235                 240 


Lys Gln Pro Ala Ile Leu Ala Lys Phe Ala Ser Lys Ile Lys Lys Asn 
                245                 250                 255     


Lys Asn Tyr Lys Ile Tyr Leu Leu Pro Gln Leu Val Val Pro Thr Tyr 
            260                 265                 270         


Asn Ala Glu Gln Leu Glu Ser Asp Val Ala Lys Glu Ile Leu Glu Tyr 
        275                 280                 285             


Thr Lys Leu Met Pro Glu Glu Arg Lys Glu Leu Leu Glu Asn Ile Leu 
    290                 295                 300                 


Ala Glu Val Asp Ser Asp Ile Ile Asp Lys Ser Leu Ser Glu Ile Glu 
305                 310                 315                 320 


Val Glu Lys Ile Ala Gln Glu Leu Glu Asn Lys Ile Arg Val Arg Asp 
                325                 330                 335     


Asp Lys Gly Asn Ser Val Pro Ile Ser Gln Leu Asn Val Gln Lys Ser 
            340                 345                 350         


Gln Leu Leu Leu Trp Thr Asn Tyr Ser Arg Lys Tyr Pro Val Ile Leu 
        355                 360                 365             


Pro Tyr Glu Val Pro Glu Lys Phe Arg Lys Ile Arg Glu Ile Pro Met 
    370                 375                 380                 


Phe Ile Ile Leu Asp Ser Gly Leu Leu Ala Asp Ile Gln Asn Phe Ala 
385                 390                 395                 400 


Thr Asn Glu Phe Arg Glu Leu Val Lys Ser Met Tyr Tyr Ser Leu Ala 
                405                 410                 415     


Lys Lys Tyr Asn Ser Leu Ala Lys Lys Ala Arg Ser Thr Asn Glu Ile 
            420                 425                 430         


Gly Leu Pro Phe Leu Asp Phe Arg Gly Lys Glu Lys Val Ile Thr Glu 
        435                 440                 445             


Asp Leu Asn Ser Asp Lys Gly Ile Ile Glu Val Val Glu Gln Val Ser 
    450                 455                 460                 


Ser Phe Met Lys Gly Lys Glu Leu Gly Leu Ala Phe Ile Ala Ala Arg 
465                 470                 475                 480 


Asn Lys Leu Ser Ser Glu Lys Phe Glu Glu Ile Lys Arg Arg Leu Phe 
                485                 490                 495     


Asn Leu Asn Val Ile Ser Gln Val Val Asn Glu Asp Thr Leu Lys Asn 
            500                 505                 510         


Lys Arg Asp Lys Tyr Asp Arg Asn Arg Leu Asp Leu Phe Val Arg His 
        515                 520                 525             


Asn Leu Leu Phe Gln Val Leu Ser Lys Leu Gly Val Lys Tyr Tyr Val 
    530                 535                 540                 


Leu Asp Tyr Arg Phe Asn Tyr Asp Tyr Ile Ile Gly Ile Asp Val Ala 
545                 550                 555                 560 


Pro Met Lys Arg Ser Glu Gly Tyr Ile Gly Gly Ser Ala Val Met Phe 
                565                 570                 575     


Asp Ser Gln Gly Tyr Ile Arg Lys Ile Val Pro Ile Lys Ile Gly Glu 
            580                 585                 590         


Gln Arg Gly Glu Ser Val Asp Met Asn Glu Phe Phe Lys Glu Met Val 
        595                 600                 605             


Asp Lys Phe Lys Glu Phe Asn Ile Lys Leu Asp Asn Lys Lys Ile Leu 
    610                 615                 620                 


Leu Leu Arg Asp Gly Arg Ile Thr Asn Asn Glu Glu Glu Gly Leu Lys 
625                 630                 635                 640 


Tyr Ile Ser Glu Met Phe Asp Ile Glu Val Val Thr Met Asp Val Ile 
                645                 650                 655     


Lys Asn His Pro Val Arg Ala Phe Ala Asn Met Lys Met Tyr Phe Asn 
            660                 665                 670         


Leu Gly Gly Ala Ile Tyr Leu Ile Pro His Lys Leu Lys Gln Ala Lys 
        675                 680                 685             


Gly Thr Pro Ile Pro Ile Lys Leu Ala Lys Lys Arg Ile Ile Lys Asn 
    690                 695                 700                 


Gly Lys Val Glu Lys Gln Ser Ile Thr Arg Gln Asp Val Leu Asp Ile 
705                 710                 715                 720 


Phe Ile Leu Thr Arg Leu Asn Tyr Gly Ser Ile Ser Ala Asp Met Arg 
                725                 730                 735     


Leu Pro Ala Pro Val His Tyr Ala His Lys Phe Ala Asn Ala Ile Arg 
            740                 745                 750         


Asn Glu Trp Lys Ile Lys Glu Glu Phe Leu Ala Glu Gly Phe Leu Tyr 
        755                 760                 765             


Phe Val 
    770 


<210>  9
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  9

Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  10
<211>  36
<212>  RNA
<213>  Artificial sequence

<220>
<223>  Synthetic nucleic acid sequence

<400>  10
uaaucccaca gccgccaguu ccgcuggcgg cauuuu                                 36


<210>  11
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  11

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  12
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  12

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  13
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  13

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  14
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  14

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  15
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  15

Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 
1               5                   10                  15      


Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 
            20                  25                  30          


Ala 
    


<210>  16
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  16

Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210>  17
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  17

Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   


<210>  18
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  18

Arg Lys Lys Arg Arg Gln Arg Arg 
1               5               


<210>  19
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  19

Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10      


<210>  20
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  20

Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 
1               5                   10      


<210>  21
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  21

Leu Phe Phe Val 
1               


<210>  22
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  22

Val Asp Arg Glu Lys Leu Phe Phe Val 
1               5                   


<210>  23
<211>  639
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  23

Met Tyr Leu Asn Leu Tyr Lys Ile Asp Ile Pro Lys Lys Ile Lys Arg 
1               5                   10                  15      


Leu Tyr Phe Tyr Asn Pro Asp Met Glu Pro Lys Leu Phe Ala Arg Asn 
            20                  25                  30          


Leu Ser Arg Val Asn Asn Phe Lys Phe Gln Asp Ser Asn Asp Leu Val 
        35                  40                  45              


Trp Ile Glu Ile Pro Asp Ile Asp Phe Gln Ile Thr Pro Lys Asn Val 
    50                  55                  60                  


Phe Gln Tyr Lys Val Glu Lys Glu Glu Ile Ile Lys Glu Glu Glu Asp 
65                  70                  75                  80  


Lys Lys Leu Phe Val Lys Thr Leu Tyr Lys Tyr Ile Lys Lys Leu Phe 
                85                  90                  95      


Leu Asp Asn Asp Phe Tyr Phe Lys Lys Gly Asn Asn Phe Ile Ser Asn 
            100                 105                 110         


Ser Glu Val Phe Ser Leu Asp Ser Asn Glu Asn Val Asn Ala His Leu 
        115                 120                 125             


Thr Tyr Lys Ile Lys Ile His Asn Ile Ser Asn Glu Tyr Tyr Leu Ser 
    130                 135                 140                 


Ile Leu Pro Lys Phe Thr Phe Leu Ser Lys Glu Pro Ala Leu Glu Ser 
145                 150                 155                 160 


Ala Ile Lys Ser Gly Tyr Leu Tyr Asn Ile Lys Ser Gly Lys Ser Phe 
                165                 170                 175     


Pro Tyr Ile Ser Gly Leu Asp Gly Ile Leu Lys Ile Asp Ile Gly Asn 
            180                 185                 190         


Asn Gln Ile Val Glu Val Ala Tyr Pro Glu Asn Tyr Leu Phe Asn Phe 
        195                 200                 205             


Thr Thr Arg Asp Ala Glu Lys Tyr Gly Phe Ser Lys Glu Val His Glu 
    210                 215                 220                 


Ile Tyr Lys Asn Lys Val Phe Glu Gly Phe Lys Lys Ile Pro Lys Thr 
225                 230                 235                 240 


Leu Gly Phe Leu Asn Lys Ile Thr Asn Leu Asn Glu Asn Tyr Gln Leu 
                245                 250                 255     


Lys Asp Gly Tyr Lys Ile Phe Ile Asn Val Ile Tyr Lys Phe Lys Asn 
            260                 265                 270         


Gly Glu Ser Arg Tyr Ala Lys Asp Val Phe Lys Tyr Ser Phe Tyr Lys 
        275                 280                 285             


Asn Glu Gln Pro Leu Lys Ala Ile Phe Phe Phe Ser Ser Lys Lys Gln 
    290                 295                 300                 


Phe Phe Glu Val Gln Lys Ser Leu Lys Glu Leu Phe His Asn Lys His 
305                 310                 315                 320 


Ser Val Phe Tyr Arg Ala Ala Ala Glu Leu Gly Phe Ser Lys Val Glu 
                325                 330                 335     


Phe Leu Arg Asp Ser Lys Thr Lys Ser Ser Ala Phe Leu Tyr Asn Pro 
            340                 345                 350         


Glu Glu Phe Thr Val Lys Asn Thr Glu Phe Phe Asn Gln Ile Lys Asp 
        355                 360                 365             


Asn Val Met Ala Ile Val Leu Leu Asp Lys Tyr Ile Gly Asn Ile Asp 
    370                 375                 380                 


Pro Leu Val Arg Asn Phe Pro Ser Gln Leu Ile Leu Gln Pro Ile Leu 
385                 390                 395                 400 


Lys Glu Lys Leu Glu Arg Ile Lys Pro Phe Ile Ile Lys Ser Tyr Val 
                405                 410                 415     


Tyr Lys Met Gly Asn Phe Ile Pro Glu Cys Lys Pro Phe Ile Leu Lys 
            420                 425                 430         


Lys Met Glu Asp Lys Glu Lys Asn Leu Tyr Ile Gly Ile Asp Leu Ser 
        435                 440                 445             


His Asp Thr Tyr Ala Arg Lys Thr Asn Leu Cys Ile Ala Ala Val Asp 
    450                 455                 460                 


Asn Thr Gly Asp Ile Leu Tyr Ile Gly Lys His Lys Asn Leu Glu Leu 
465                 470                 475                 480 


Asn Glu Lys Met Asn Leu Asp Ile Leu Glu Lys Glu Tyr Ile Lys Ala 
                485                 490                 495     


Phe Glu Lys Tyr Ile Glu Lys Phe Asn Val Ser Pro Glu Asn Val Phe 
            500                 505                 510         


Ile Leu Arg Asp Gly Arg Phe Ile Glu Asp Ile Glu Ile Ile Lys Asn 
        515                 520                 525             


Phe Ile Ser Tyr Asn Asp Thr Lys Tyr Thr Leu Val Glu Val Asn Lys 
    530                 535                 540                 


Asn Thr Asn Ile Asn Ser Tyr Asp Asp Leu Lys Glu Trp Ile Ile Lys 
545                 550                 555                 560 


Leu Asp Glu Asn Thr Tyr Ile Tyr Tyr Pro Lys Thr Phe Leu Asn Gln 
                565                 570                 575     


Lys Gly Val Glu Val Lys Ile Leu Glu Asn Asn Thr Asp Tyr Thr Ile 
            580                 585                 590         


Glu Glu Ile Ile Glu Gln Ile Tyr Leu Leu Thr Arg Val Ala His Ser 
        595                 600                 605             


Thr Pro Tyr Thr Asn Tyr Lys Leu Pro Tyr Pro Leu His Ile Ala Asn 
    610                 615                 620                 


Lys Val Ala Leu Thr Asp Tyr Glu Trp Lys Leu Tyr Ile Pro Tyr 
625                 630                 635                 


<210>  24
<211>  643
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  24

Met Tyr Leu Asn Leu Tyr Lys Ile Asp Ile Pro Lys Lys Ile Lys Arg 
1               5                   10                  15      


Leu Tyr Phe Tyr Asn Pro Asp Met Glu Pro Lys Leu Phe Ala Arg Asn 
            20                  25                  30          


Leu Ser Arg Val Asn Asn Phe Lys Phe Gln Asp Ser Asn Asp Leu Val 
        35                  40                  45              


Trp Ile Glu Ile Pro Asp Ile Asp Phe Gln Ile Thr Pro Lys Asn Val 
    50                  55                  60                  


Phe Gln Tyr Lys Val Glu Lys Glu Glu Ile Ile Lys Glu Glu Glu Asp 
65                  70                  75                  80  


Lys Lys Leu Phe Val Lys Thr Leu Tyr Lys Tyr Ile Lys Lys Leu Phe 
                85                  90                  95      


Leu Asp Asn Asp Phe Tyr Phe Lys Lys Gly Asn Asn Phe Ile Ser Asn 
            100                 105                 110         


Ser Glu Val Phe Ser Leu Asp Ser Asn Glu Asn Val Asn Ala His Leu 
        115                 120                 125             


Thr Tyr Lys Ile Lys Ile His Asn Ile Ser Asn Glu Tyr Tyr Leu Ser 
    130                 135                 140                 


Ile Leu Pro Lys Phe Thr Phe Leu Ser Lys Glu Pro Ala Leu Glu Ser 
145                 150                 155                 160 


Ala Ile Lys Ser Gly Tyr Leu Tyr Asn Ile Lys Ser Gly Lys Ser Phe 
                165                 170                 175     


Pro Tyr Ile Ser Gly Leu Asp Gly Ile Leu Lys Ile Asp Ile Gly Asn 
            180                 185                 190         


Asn Gln Ile Val Glu Val Ala Tyr Pro Glu Asn Tyr Leu Phe Asn Phe 
        195                 200                 205             


Thr Thr Arg Asp Ala Glu Lys Tyr Gly Phe Ser Lys Glu Val His Glu 
    210                 215                 220                 


Ile Tyr Lys Asn Lys Val Phe Glu Gly Phe Lys Lys Ile Pro Lys Thr 
225                 230                 235                 240 


Leu Gly Phe Leu Asn Lys Ile Thr Asn Leu Asn Glu Asn Tyr Gln Leu 
                245                 250                 255     


Lys Asp Gly Tyr Lys Ile Phe Ile Asn Val Ile Tyr Lys Phe Lys Asn 
            260                 265                 270         


Gly Glu Ser Arg Tyr Ala Lys Asp Val Phe Lys Tyr Ser Phe Tyr Lys 
        275                 280                 285             


Asn Glu Gln Pro Leu Lys Ala Ile Phe Phe Phe Ser Ser Lys Lys Gln 
    290                 295                 300                 


Phe Phe Glu Val Gln Lys Ser Leu Lys Glu Leu Phe His Asn Lys His 
305                 310                 315                 320 


Ser Val Phe Tyr Arg Ala Ala Ala Glu Leu Gly Phe Ser Lys Val Glu 
                325                 330                 335     


Phe Leu Arg Asp Ser Lys Thr Lys Ser Ser Ala Phe Leu Tyr Asn Pro 
            340                 345                 350         


Glu Glu Phe Thr Val Lys Asn Thr Glu Phe Phe Asn Gln Ile Lys Asp 
        355                 360                 365             


Asn Val Met Ala Ile Val Leu Leu Asp Lys Tyr Ile Gly Asn Ile Asp 
    370                 375                 380                 


Pro Leu Val Arg Asn Phe Pro Ser Gln Leu Ile Leu Gln Pro Ile Leu 
385                 390                 395                 400 


Lys Glu Lys Leu Glu Arg Ile Lys Pro Phe Ile Ile Lys Ser Tyr Val 
                405                 410                 415     


Tyr Lys Met Gly Asn Phe Ile Pro Glu Cys Lys Pro Phe Ile Leu Lys 
            420                 425                 430         


Lys Met Glu Asp Lys Glu Lys Asn Leu Tyr Ile Gly Ile Asp Leu Ser 
        435                 440                 445             


His Asp Thr Tyr Ala Arg Lys Thr Asn Leu Cys Ile Ala Ala Val Asp 
    450                 455                 460                 


Asn Thr Gly Asp Ile Leu Tyr Ile Gly Lys His Lys Asn Leu Glu Leu 
465                 470                 475                 480 


Asn Glu Lys Met Asn Leu Asp Ile Leu Glu Lys Glu Tyr Ile Lys Ala 
                485                 490                 495     


Phe Glu Lys Tyr Ile Glu Lys Phe Asn Val Ser Pro Glu Asn Val Phe 
            500                 505                 510         


Ile Leu Arg Asp Gly Arg Phe Ile Glu Asp Ile Glu Ile Ile Lys Asn 
        515                 520                 525             


Phe Ile Ser Tyr Asn Asp Thr Lys Tyr Thr Leu Val Glu Val Asn Lys 
    530                 535                 540                 


Asn Thr Asn Ile Asn Ser Tyr Asp Asp Leu Lys Glu Trp Ile Ile Lys 
545                 550                 555                 560 


Leu Asp Glu Asn Thr Tyr Ile Tyr Tyr Pro Lys Thr Phe Leu Asn Gln 
                565                 570                 575     


Lys Gly Val Glu Val Lys Ile Leu Glu Asn Asn Thr Asp Tyr Thr Ile 
            580                 585                 590         


Glu Glu Ile Ile Glu Gln Ile Tyr Leu Leu Thr Arg Val Ala His Ser 
        595                 600                 605             


Thr Pro Tyr Thr Asn Tyr Lys Leu Pro Tyr Pro Leu His Ile Ala Asn 
    610                 615                 620                 


Lys Val Ala Leu Thr Asp Tyr Glu Trp Lys Leu Tyr Ile Pro Tyr Leu 
625                 630                 635                 640 


Phe Phe Val 
            


<210>  25
<211>  648
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic amino acid sequence

<400>  25

Met Tyr Leu Asn Leu Tyr Lys Ile Asp Ile Pro Lys Lys Ile Lys Arg 
1               5                   10                  15      


Leu Tyr Phe Tyr Asn Pro Asp Met Glu Pro Lys Leu Phe Ala Arg Asn 
            20                  25                  30          


Leu Ser Arg Val Asn Asn Phe Lys Phe Gln Asp Ser Asn Asp Leu Val 
        35                  40                  45              


Trp Ile Glu Ile Pro Asp Ile Asp Phe Gln Ile Thr Pro Lys Asn Val 
    50                  55                  60                  


Phe Gln Tyr Lys Val Glu Lys Glu Glu Ile Ile Lys Glu Glu Glu Asp 
65                  70                  75                  80  


Lys Lys Leu Phe Val Lys Thr Leu Tyr Lys Tyr Ile Lys Lys Leu Phe 
                85                  90                  95      


Leu Asp Asn Asp Phe Tyr Phe Lys Lys Gly Asn Asn Phe Ile Ser Asn 
            100                 105                 110         


Ser Glu Val Phe Ser Leu Asp Ser Asn Glu Asn Val Asn Ala His Leu 
        115                 120                 125             


Thr Tyr Lys Ile Lys Ile His Asn Ile Ser Asn Glu Tyr Tyr Leu Ser 
    130                 135                 140                 


Ile Leu Pro Lys Phe Thr Phe Leu Ser Lys Glu Pro Ala Leu Glu Ser 
145                 150                 155                 160 


Ala Ile Lys Ser Gly Tyr Leu Tyr Asn Ile Lys Ser Gly Lys Ser Phe 
                165                 170                 175     


Pro Tyr Ile Ser Gly Leu Asp Gly Ile Leu Lys Ile Asp Ile Gly Asn 
            180                 185                 190         


Asn Gln Ile Val Glu Val Ala Tyr Pro Glu Asn Tyr Leu Phe Asn Phe 
        195                 200                 205             


Thr Thr Arg Asp Ala Glu Lys Tyr Gly Phe Ser Lys Glu Val His Glu 
    210                 215                 220                 


Ile Tyr Lys Asn Lys Val Phe Glu Gly Phe Lys Lys Ile Pro Lys Thr 
225                 230                 235                 240 


Leu Gly Phe Leu Asn Lys Ile Thr Asn Leu Asn Glu Asn Tyr Gln Leu 
                245                 250                 255     


Lys Asp Gly Tyr Lys Ile Phe Ile Asn Val Ile Tyr Lys Phe Lys Asn 
            260                 265                 270         


Gly Glu Ser Arg Tyr Ala Lys Asp Val Phe Lys Tyr Ser Phe Tyr Lys 
        275                 280                 285             


Asn Glu Gln Pro Leu Lys Ala Ile Phe Phe Phe Ser Ser Lys Lys Gln 
    290                 295                 300                 


Phe Phe Glu Val Gln Lys Ser Leu Lys Glu Leu Phe His Asn Lys His 
305                 310                 315                 320 


Ser Val Phe Tyr Arg Ala Ala Ala Glu Leu Gly Phe Ser Lys Val Glu 
                325                 330                 335     


Phe Leu Arg Asp Ser Lys Thr Lys Ser Ser Ala Phe Leu Tyr Asn Pro 
            340                 345                 350         


Glu Glu Phe Thr Val Lys Asn Thr Glu Phe Phe Asn Gln Ile Lys Asp 
        355                 360                 365             


Asn Val Met Ala Ile Val Leu Leu Asp Lys Tyr Ile Gly Asn Ile Asp 
    370                 375                 380                 


Pro Leu Val Arg Asn Phe Pro Ser Gln Leu Ile Leu Gln Pro Ile Leu 
385                 390                 395                 400 


Lys Glu Lys Leu Glu Arg Ile Lys Pro Phe Ile Ile Lys Ser Tyr Val 
                405                 410                 415     


Tyr Lys Met Gly Asn Phe Ile Pro Glu Cys Lys Pro Phe Ile Leu Lys 
            420                 425                 430         


Lys Met Glu Asp Lys Glu Lys Asn Leu Tyr Ile Gly Ile Asp Leu Ser 
        435                 440                 445             


His Asp Thr Tyr Ala Arg Lys Thr Asn Leu Cys Ile Ala Ala Val Asp 
    450                 455                 460                 


Asn Thr Gly Asp Ile Leu Tyr Ile Gly Lys His Lys Asn Leu Glu Leu 
465                 470                 475                 480 


Asn Glu Lys Met Asn Leu Asp Ile Leu Glu Lys Glu Tyr Ile Lys Ala 
                485                 490                 495     


Phe Glu Lys Tyr Ile Glu Lys Phe Asn Val Ser Pro Glu Asn Val Phe 
            500                 505                 510         


Ile Leu Arg Asp Gly Arg Phe Ile Glu Asp Ile Glu Ile Ile Lys Asn 
        515                 520                 525             


Phe Ile Ser Tyr Asn Asp Thr Lys Tyr Thr Leu Val Glu Val Asn Lys 
    530                 535                 540                 


Asn Thr Asn Ile Asn Ser Tyr Asp Asp Leu Lys Glu Trp Ile Ile Lys 
545                 550                 555                 560 


Leu Asp Glu Asn Thr Tyr Ile Tyr Tyr Pro Lys Thr Phe Leu Asn Gln 
                565                 570                 575     


Lys Gly Val Glu Val Lys Ile Leu Glu Asn Asn Thr Asp Tyr Thr Ile 
            580                 585                 590         


Glu Glu Ile Ile Glu Gln Ile Tyr Leu Leu Thr Arg Val Ala His Ser 
        595                 600                 605             


Thr Pro Tyr Thr Asn Tyr Lys Leu Pro Tyr Pro Leu His Ile Ala Asn 
    610                 615                 620                 


Lys Val Ala Leu Thr Asp Tyr Glu Trp Lys Leu Tyr Ile Pro Tyr Val 
625                 630                 635                 640 


Asp Arg Glu Lys Leu Phe Phe Val 
                645             


<210>  26
<211>  859
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Tyr Ser Gly Ala Gly Pro Ala Leu Ala Pro Pro Ala Pro Pro Pro 
1               5                   10                  15      


Pro Ile Gln Gly Tyr Ala Phe Lys Pro Pro Pro Arg Pro Asp Phe Gly 
            20                  25                  30          


Thr Ser Gly Arg Thr Ile Lys Leu Gln Ala Asn Phe Phe Glu Met Asp 
        35                  40                  45              


Ile Pro Lys Ile Asp Ile Tyr His Tyr Glu Leu Asp Ile Lys Pro Glu 
    50                  55                  60                  


Lys Cys Pro Arg Arg Val Asn Arg Glu Ile Val Glu His Met Val Gln 
65                  70                  75                  80  


His Phe Lys Thr Gln Ile Phe Gly Asp Arg Lys Pro Val Phe Asp Gly 
                85                  90                  95      


Arg Lys Asn Leu Tyr Thr Ala Met Pro Leu Pro Ile Gly Arg Asp Lys 
            100                 105                 110         


Val Glu Leu Glu Val Thr Leu Pro Gly Glu Gly Lys Asp Arg Ile Phe 
        115                 120                 125             


Lys Val Ser Ile Lys Trp Val Ser Cys Val Ser Leu Gln Ala Leu His 
    130                 135                 140                 


Asp Ala Leu Ser Gly Arg Leu Pro Ser Val Pro Phe Glu Thr Ile Gln 
145                 150                 155                 160 


Ala Leu Asp Val Val Met Arg His Leu Pro Ser Met Arg Tyr Thr Pro 
                165                 170                 175     


Val Gly Arg Ser Phe Phe Thr Ala Ser Glu Gly Cys Ser Asn Pro Leu 
            180                 185                 190         


Gly Gly Gly Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg Pro 
        195                 200                 205             


Ser Leu Trp Lys Met Met Leu Asn Ile Asp Val Ser Ala Thr Ala Phe 
    210                 215                 220                 


Tyr Lys Ala Gln Pro Val Ile Glu Phe Val Cys Glu Val Leu Asp Phe 
225                 230                 235                 240 


Lys Ser Ile Glu Glu Gln Gln Lys Pro Leu Thr Asp Ser Gln Arg Val 
                245                 250                 255     


Lys Phe Thr Lys Glu Ile Lys Gly Leu Lys Val Glu Ile Thr His Cys 
            260                 265                 270         


Gly Gln Met Lys Arg Lys Tyr Arg Val Cys Asn Val Thr Arg Arg Pro 
        275                 280                 285             


Ala Ser His Gln Thr Phe Pro Leu Gln Gln Glu Ser Gly Gln Thr Val 
    290                 295                 300                 


Glu Cys Thr Val Ala Gln Tyr Phe Lys Asp Arg His Lys Leu Val Leu 
305                 310                 315                 320 


Arg Tyr Pro His Leu Pro Cys Leu Gln Val Gly Gln Glu Gln Lys His 
                325                 330                 335     


Thr Tyr Leu Pro Leu Glu Val Cys Asn Ile Val Ala Gly Gln Arg Cys 
            340                 345                 350         


Ile Lys Lys Leu Thr Asp Asn Gln Thr Ser Thr Met Ile Arg Ala Thr 
        355                 360                 365             


Ala Arg Ser Ala Pro Asp Arg Gln Glu Glu Ile Ser Lys Leu Met Arg 
    370                 375                 380                 


Ser Ala Ser Phe Asn Thr Asp Pro Tyr Val Arg Glu Phe Gly Ile Met 
385                 390                 395                 400 


Val Lys Asp Glu Met Thr Asp Val Thr Gly Arg Val Leu Gln Pro Pro 
                405                 410                 415     


Ser Ile Leu Tyr Gly Gly Arg Asn Lys Ala Ile Ala Thr Pro Val Gln 
            420                 425                 430         


Gly Val Trp Asp Met Arg Asn Lys Gln Phe His Thr Gly Ile Glu Ile 
        435                 440                 445             


Lys Val Trp Ala Ile Ala Cys Phe Ala Pro Gln Arg Gln Cys Thr Glu 
    450                 455                 460                 


Val His Leu Lys Ser Phe Thr Glu Gln Leu Arg Lys Ile Ser Arg Asp 
465                 470                 475                 480 


Ala Gly Met Pro Ile Gln Gly Gln Pro Cys Phe Cys Lys Tyr Ala Gln 
                485                 490                 495     


Gly Ala Asp Ser Val Glu Pro Met Phe Arg His Leu Lys Asn Thr Tyr 
            500                 505                 510         


Ala Gly Leu Gln Leu Val Val Val Ile Leu Pro Gly Lys Thr Pro Val 
        515                 520                 525             


Tyr Ala Glu Val Lys Arg Val Gly Asp Thr Val Leu Gly Met Ala Thr 
    530                 535                 540                 


Gln Cys Val Gln Met Lys Asn Val Gln Arg Thr Thr Pro Gln Thr Leu 
545                 550                 555                 560 


Ser Asn Leu Cys Leu Lys Ile Asn Val Lys Leu Gly Gly Val Asn Asn 
                565                 570                 575     


Ile Leu Leu Pro Gln Gly Arg Pro Pro Val Phe Gln Gln Pro Val Ile 
            580                 585                 590         


Phe Leu Gly Ala Asp Val Thr His Pro Pro Ala Gly Asp Gly Lys Lys 
        595                 600                 605             


Pro Ser Ile Ala Ala Val Val Gly Ser Met Asp Ala His Pro Asn Arg 
    610                 615                 620                 


Tyr Cys Ala Thr Val Arg Val Gln Gln His Arg Gln Glu Ile Ile Gln 
625                 630                 635                 640 


Asp Leu Ala Ala Met Val Arg Glu Leu Leu Ile Gln Phe Tyr Lys Ser 
                645                 650                 655     


Thr Arg Phe Lys Pro Thr Arg Ile Ile Phe Tyr Arg Asp Gly Val Ser 
            660                 665                 670         


Glu Gly Gln Phe Gln Gln Val Leu His His Glu Leu Leu Ala Ile Arg 
        675                 680                 685             


Glu Ala Cys Ile Lys Leu Glu Lys Asp Tyr Gln Pro Gly Ile Thr Phe 
    690                 695                 700                 


Ile Val Val Gln Lys Arg His His Thr Arg Leu Phe Cys Thr Asp Lys 
705                 710                 715                 720 


Asn Glu Arg Val Gly Lys Ser Gly Asn Ile Pro Ala Gly Thr Thr Val 
                725                 730                 735     


Asp Thr Lys Ile Thr His Pro Thr Glu Phe Asp Phe Tyr Leu Cys Ser 
            740                 745                 750         


His Ala Gly Ile Gln Gly Thr Ser Arg Pro Ser His Tyr His Val Leu 
        755                 760                 765             


Trp Asp Asp Asn Arg Phe Ser Ser Asp Glu Leu Gln Ile Leu Thr Tyr 
    770                 775                 780                 


Gln Leu Cys His Thr Tyr Val Arg Cys Thr Arg Ser Val Ser Ile Pro 
785                 790                 795                 800 


Ala Pro Ala Tyr Tyr Ala His Leu Val Ala Phe Arg Ala Arg Tyr His 
                805                 810                 815     


Leu Val Asp Lys Glu His Asp Ser Ala Glu Gly Ser His Thr Ser Gly 
            820                 825                 830         


Gln Ser Asn Gly Arg Asp His Gln Ala Leu Ala Lys Ala Val Gln Val 
        835                 840                 845             


His Gln Asp Thr Leu Arg Thr Met Tyr Phe Ala 
    850                 855                 


<210>  27
<211>  984
<212>  PRT
<213>  Drosophila melanogaster

<400>  27

Met Ser Thr Glu Arg Glu Leu Ala Pro Gly Gly Pro Ala Gln Leu His 
1               5                   10                  15      


Pro His Thr Leu Pro Leu Thr Phe Pro Asp Leu Gln Met Thr Ser Thr 
            20                  25                  30          


Val Gly Ile Ile Gly Lys Val Tyr Glu Ser Gln Trp Thr Pro Ser Pro 
        35                  40                  45              


Thr Arg Pro Gln Ser Pro Ser Gln Ala Gln Thr Ser Phe Asp Thr Leu 
    50                  55                  60                  


Thr Ser Pro Pro Ala Pro Gly Ser Ser Val Asn Pro Thr Ala Val Thr 
65                  70                  75                  80  


Ser Pro Ser Ala Gln Asn Val Ala Ala Gly Gly Ala Thr Val Ala Gly 
                85                  90                  95      


Ala Ala Ala Thr Ala Ala Gln Val Ala Ser Ala Leu Gly Ala Thr Thr 
            100                 105                 110         


Gly Ser Val Thr Pro Ala Ile Ala Thr Ala Thr Pro Ala Thr Gln Pro 
        115                 120                 125             


Asp Met Pro Val Phe Thr Cys Pro Arg Arg Pro Asn Leu Gly Arg Glu 
    130                 135                 140                 


Gly Arg Pro Ile Val Leu Arg Ala Asn His Phe Gln Val Thr Met Pro 
145                 150                 155                 160 


Arg Gly Tyr Val His His Tyr Asp Ile Asn Ile Gln Pro Asp Lys Cys 
                165                 170                 175     


Pro Arg Lys Val Asn Arg Glu Ile Ile Glu Thr Met Val His Ala Tyr 
            180                 185                 190         


Ser Lys Ile Phe Gly Val Leu Lys Pro Val Phe Asp Gly Arg Asn Asn 
        195                 200                 205             


Leu Tyr Thr Arg Asp Pro Leu Pro Ile Gly Asn Glu Arg Leu Glu Leu 
    210                 215                 220                 


Glu Val Thr Leu Pro Gly Glu Gly Lys Asp Arg Ile Phe Arg Val Thr 
225                 230                 235                 240 


Ile Lys Trp Gln Ala Gln Val Ser Leu Phe Asn Leu Glu Glu Ala Leu 
                245                 250                 255     


Glu Gly Arg Thr Arg Gln Ile Pro Tyr Asp Ala Ile Leu Ala Leu Asp 
            260                 265                 270         


Val Val Met Arg His Leu Pro Ser Met Thr Tyr Thr Pro Val Gly Arg 
        275                 280                 285             


Ser Phe Phe Ser Ser Pro Glu Gly Tyr Tyr His Pro Leu Gly Gly Gly 
    290                 295                 300                 


Arg Glu Val Trp Phe Gly Phe His Gln Ser Val Arg Pro Ser Gln Trp 
305                 310                 315                 320 


Lys Met Met Leu Asn Ile Asp Val Ser Ala Thr Ala Phe Tyr Lys Ala 
                325                 330                 335     


Gln Pro Val Ile Asp Phe Met Cys Glu Val Leu Asp Ile Arg Asp Ile 
            340                 345                 350         


Asn Glu Gln Arg Lys Pro Leu Thr Asp Ser Gln Arg Val Lys Phe Thr 
        355                 360                 365             


Lys Glu Ile Lys Gly Leu Lys Ile Glu Ile Thr His Cys Gly Gln Met 
    370                 375                 380                 


Arg Arg Lys Tyr Arg Val Cys Asn Val Thr Arg Arg Pro Ala Gln Met 
385                 390                 395                 400 


Gln Ser Phe Pro Leu Gln Leu Glu Asn Gly Gln Thr Val Glu Cys Thr 
                405                 410                 415     


Val Ala Lys Tyr Phe Leu Asp Lys Tyr Arg Met Lys Leu Arg Tyr Pro 
            420                 425                 430         


His Leu Pro Cys Leu Gln Val Gly Gln Glu His Lys His Thr Tyr Leu 
        435                 440                 445             


Pro Leu Glu Val Cys Asn Ile Val Ala Gly Gln Arg Cys Ile Lys Lys 
    450                 455                 460                 


Leu Thr Asp Met Gln Thr Ser Thr Met Ile Lys Ala Thr Ala Arg Ser 
465                 470                 475                 480 


Ala Pro Asp Arg Glu Arg Glu Ile Asn Asn Leu Val Lys Arg Ala Asp 
                485                 490                 495     


Phe Asn Asn Asp Ser Tyr Val Gln Glu Phe Gly Leu Thr Ile Ser Asn 
            500                 505                 510         


Ser Met Met Glu Val Arg Gly Arg Val Leu Pro Pro Pro Lys Leu Gln 
        515                 520                 525             


Tyr Gly Gly Arg Val Ser Thr Gly Leu Thr Gly Gln Gln Leu Phe Pro 
    530                 535                 540                 


Pro Gln Asn Lys Val Ser Leu Ala Ser Pro Asn Gln Gly Val Trp Asp 
545                 550                 555                 560 


Met Arg Gly Lys Gln Phe Phe Thr Gly Val Glu Ile Arg Ile Trp Ala 
                565                 570                 575     


Ile Ala Cys Phe Ala Pro Gln Arg Thr Val Arg Glu Asp Ala Leu Arg 
            580                 585                 590         


Asn Phe Thr Gln Gln Leu Gln Lys Ile Ser Asn Asp Ala Gly Met Pro 
        595                 600                 605             


Ile Ile Gly Gln Pro Cys Phe Cys Lys Tyr Ala Thr Gly Pro Asp Gln 
    610                 615                 620                 


Val Glu Pro Met Phe Arg Tyr Leu Lys Ile Thr Phe Pro Gly Leu Gln 
625                 630                 635                 640 


Leu Val Val Val Val Leu Pro Gly Lys Thr Pro Val Tyr Ala Glu Val 
                645                 650                 655     


Lys Arg Val Gly Asp Thr Val Leu Gly Met Ala Thr Gln Cys Val Gln 
            660                 665                 670         


Ala Lys Asn Val Asn Lys Thr Ser Pro Gln Thr Leu Ser Asn Leu Cys 
        675                 680                 685             


Leu Lys Ile Asn Val Lys Leu Gly Gly Ile Asn Ser Ile Leu Val Pro 
    690                 695                 700                 


Ser Ile Arg Pro Lys Val Phe Asn Glu Pro Val Ile Phe Leu Gly Ala 
705                 710                 715                 720 


Asp Val Thr His Pro Pro Ala Gly Asp Asn Lys Lys Pro Ser Ile Ala 
                725                 730                 735     


Ala Val Val Gly Ser Met Asp Ala His Pro Ser Arg Tyr Ala Ala Thr 
            740                 745                 750         


Val Arg Val Gln Gln His Arg Gln Glu Ile Ile Gln Glu Leu Ser Ser 
        755                 760                 765             


Met Val Arg Glu Leu Leu Ile Met Phe Tyr Lys Ser Thr Gly Gly Tyr 
    770                 775                 780                 


Lys Pro His Arg Ile Ile Leu Tyr Arg Asp Gly Val Ser Glu Gly Gln 
785                 790                 795                 800 


Phe Pro His Val Leu Gln His Glu Leu Thr Ala Ile Arg Glu Ala Cys 
                805                 810                 815     


Ile Lys Leu Glu Pro Glu Tyr Arg Pro Gly Ile Thr Phe Ile Val Val 
            820                 825                 830         


Gln Lys Arg His His Thr Arg Leu Phe Cys Ala Glu Lys Lys Glu Gln 
        835                 840                 845             


Ser Gly Lys Ser Gly Asn Ile Pro Ala Gly Thr Thr Val Asp Val Gly 
    850                 855                 860                 


Ile Thr His Pro Thr Glu Phe Asp Phe Tyr Leu Cys Ser His Gln Gly 
865                 870                 875                 880 


Ile Gln Gly Thr Ser Arg Pro Ser His Tyr His Val Leu Trp Asp Asp 
                885                 890                 895     


Asn His Phe Asp Ser Asp Glu Leu Gln Cys Leu Thr Tyr Gln Leu Cys 
            900                 905                 910         


His Thr Tyr Val Arg Cys Thr Arg Ser Val Ser Ile Pro Ala Pro Ala 
        915                 920                 925             


Tyr Tyr Ala His Leu Val Ala Phe Arg Ala Arg Tyr His Leu Val Glu 
    930                 935                 940                 


Lys Glu His Asp Ser Gly Glu Gly Ser His Gln Ser Gly Cys Ser Glu 
945                 950                 955                 960 


Asp Arg Thr Pro Gly Ala Met Ala Arg Ala Ile Thr Val His Ala Asp 
                965                 970                 975     


Thr Lys Lys Val Met Tyr Phe Ala 
            980                 


<210>  28
<211>  685
<212>  PRT
<213>  Thermus thermophilus

<400>  28

Met Asn His Leu Gly Lys Thr Glu Val Phe Leu Asn Arg Phe Ala Leu 
1               5                   10                  15      


Arg Pro Leu Asn Pro Glu Glu Leu Arg Pro Trp Arg Leu Glu Val Val 
            20                  25                  30          


Leu Asp Pro Pro Pro Gly Arg Glu Glu Val Tyr Pro Leu Leu Ala Gln 
        35                  40                  45              


Val Ala Arg Arg Ala Gly Gly Val Thr Val Arg Met Gly Asp Gly Leu 
    50                  55                  60                  


Ala Ser Trp Ser Pro Pro Glu Val Leu Val Leu Glu Gly Thr Leu Ala 
65                  70                  75                  80  


Arg Met Gly Gln Thr Tyr Ala Tyr Arg Leu Tyr Pro Lys Gly Arg Arg 
                85                  90                  95      


Pro Leu Asp Pro Lys Asp Pro Gly Glu Arg Ser Val Leu Ser Ala Leu 
            100                 105                 110         


Ala Arg Arg Leu Leu Gln Glu Arg Leu Arg Arg Leu Glu Gly Val Trp 
        115                 120                 125             


Val Glu Gly Leu Ala Val Tyr Arg Arg Glu His Ala Arg Gly Pro Gly 
    130                 135                 140                 


Trp Arg Val Leu Gly Gly Ala Val Leu Asp Leu Trp Val Ser Asp Ser 
145                 150                 155                 160 


Gly Ala Phe Leu Leu Glu Val Asp Pro Ala Tyr Arg Ile Leu Cys Glu 
                165                 170                 175     


Met Ser Leu Glu Ala Trp Leu Ala Gln Gly His Pro Leu Pro Lys Arg 
            180                 185                 190         


Val Arg Asn Ala Tyr Asp Arg Arg Thr Trp Glu Leu Leu Arg Leu Gly 
        195                 200                 205             


Glu Glu Asp Pro Lys Glu Leu Pro Leu Pro Gly Gly Leu Ser Leu Leu 
    210                 215                 220                 


Asp Tyr His Ala Ser Lys Gly Arg Leu Gln Gly Arg Glu Gly Gly Arg 
225                 230                 235                 240 


Val Ala Trp Val Ala Asp Pro Lys Asp Pro Arg Lys Pro Ile Pro His 
                245                 250                 255     


Leu Thr Gly Leu Leu Val Pro Val Leu Thr Leu Glu Asp Leu His Glu 
            260                 265                 270         


Glu Glu Gly Ser Leu Ala Leu Ser Leu Pro Trp Glu Glu Arg Arg Arg 
        275                 280                 285             


Arg Thr Arg Glu Ile Ala Ser Trp Ile Gly Arg Arg Leu Gly Leu Gly 
    290                 295                 300                 


Thr Pro Glu Ala Val Arg Ala Gln Ala Tyr Arg Leu Ser Ile Pro Lys 
305                 310                 315                 320 


Leu Met Gly Arg Arg Ala Val Ser Lys Pro Ala Asp Ala Leu Arg Val 
                325                 330                 335     


Gly Phe Tyr Arg Ala Gln Glu Thr Ala Leu Ala Leu Leu Arg Leu Asp 
            340                 345                 350         


Gly Ala Gln Gly Trp Pro Glu Phe Leu Arg Arg Ala Leu Leu Arg Ala 
        355                 360                 365             


Phe Gly Ala Ser Gly Ala Ser Leu Arg Leu His Thr Leu His Ala His 
    370                 375                 380                 


Pro Ser Gln Gly Leu Ala Phe Arg Glu Ala Leu Arg Lys Ala Lys Glu 
385                 390                 395                 400 


Glu Gly Val Gln Ala Val Leu Val Leu Thr Pro Pro Met Ala Trp Glu 
                405                 410                 415     


Asp Arg Asn Arg Leu Lys Ala Leu Leu Leu Arg Glu Gly Leu Pro Ser 
            420                 425                 430         


Gln Ile Leu Asn Val Pro Leu Arg Glu Glu Glu Arg His Arg Trp Glu 
        435                 440                 445             


Asn Ala Leu Leu Gly Leu Leu Ala Lys Ala Gly Leu Gln Val Val Ala 
    450                 455                 460                 


Leu Ser Gly Ala Tyr Pro Ala Glu Leu Ala Val Gly Phe Asp Ala Gly 
465                 470                 475                 480 


Gly Arg Glu Ser Phe Arg Phe Gly Gly Ala Ala Cys Ala Val Gly Gly 
                485                 490                 495     


Asp Gly Gly His Leu Leu Trp Thr Leu Pro Glu Ala Gln Ala Gly Glu 
            500                 505                 510         


Arg Ile Pro Gln Glu Val Val Trp Asp Leu Leu Glu Glu Thr Leu Trp 
        515                 520                 525             


Ala Phe Arg Arg Lys Ala Gly Arg Leu Pro Ser Arg Val Leu Leu Leu 
    530                 535                 540                 


Arg Asp Gly Arg Val Pro Gln Asp Glu Phe Ala Leu Ala Leu Glu Ala 
545                 550                 555                 560 


Leu Ala Arg Glu Gly Ile Ala Tyr Asp Leu Val Ser Val Arg Lys Ser 
                565                 570                 575     


Gly Gly Gly Arg Val Tyr Pro Val Gln Gly Arg Leu Ala Asp Gly Leu 
            580                 585                 590         


Tyr Val Pro Leu Glu Asp Lys Thr Phe Leu Leu Leu Thr Val His Arg 
        595                 600                 605             


Asp Phe Arg Gly Thr Pro Arg Pro Leu Lys Leu Val His Glu Ala Gly 
    610                 615                 620                 


Asp Thr Pro Leu Glu Ala Leu Ala His Gln Ile Phe His Leu Thr Arg 
625                 630                 635                 640 


Leu Tyr Pro Ala Ser Gly Phe Ala Phe Pro Arg Leu Pro Ala Pro Leu 
                645                 650                 655     


His Leu Ala Asp Arg Leu Val Lys Glu Val Gly Arg Leu Gly Ile Arg 
            660                 665                 670         


His Leu Lys Glu Val Asp Arg Glu Lys Leu Phe Phe Val 
        675                 680                 685 


<210>  29
<211>  771
<212>  PRT
<213>  Pyrococcus furiosus

<400>  29

Ser Met Lys Ala Ile Val Val Ile Asn Leu Val Lys Ile Asn Lys Lys 
1               5                   10                  15      


Ile Ile Pro Asp Lys Ile Tyr Val Tyr Arg Leu Phe Asn Asp Pro Glu 
            20                  25                  30          


Glu Glu Leu Gln Lys Glu Gly Tyr Ser Ile Tyr Arg Leu Ala Tyr Glu 
        35                  40                  45              


Asn Val Gly Ile Val Ile Asp Pro Glu Asn Leu Ile Ile Ala Thr Thr 
    50                  55                  60                  


Lys Glu Leu Glu Tyr Glu Gly Glu Phe Ile Pro Glu Gly Glu Ile Ser 
65                  70                  75                  80  


Phe Ser Glu Leu Arg Asn Asp Tyr Gln Ser Lys Leu Val Leu Arg Leu 
                85                  90                  95      


Leu Lys Glu Asn Gly Ile Gly Glu Tyr Glu Leu Ser Lys Leu Leu Arg 
            100                 105                 110         


Lys Phe Arg Lys Pro Lys Thr Phe Gly Asp Tyr Lys Val Ile Pro Ser 
        115                 120                 125             


Val Glu Met Ser Val Ile Lys His Asp Glu Asp Phe Tyr Leu Val Ile 
    130                 135                 140                 


His Ile Ile His Gln Ile Gln Ser Met Lys Thr Leu Trp Glu Leu Val 
145                 150                 155                 160 


Asn Lys Asp Pro Lys Glu Leu Glu Glu Phe Leu Met Thr His Lys Glu 
                165                 170                 175     


Asn Leu Met Leu Lys Asp Ile Ala Ser Pro Leu Lys Thr Val Tyr Lys 
            180                 185                 190         


Pro Cys Phe Glu Glu Tyr Thr Lys Lys Pro Lys Leu Asp His Asn Gln 
        195                 200                 205             


Glu Ile Val Lys Tyr Trp Tyr Asn Tyr His Ile Glu Arg Tyr Trp Asn 
    210                 215                 220                 


Thr Pro Glu Ala Lys Leu Glu Phe Tyr Arg Lys Phe Gly Gln Val Asp 
225                 230                 235                 240 


Leu Lys Gln Pro Ala Ile Leu Ala Lys Phe Ala Ser Lys Ile Lys Lys 
                245                 250                 255     


Asn Lys Asn Tyr Lys Ile Tyr Leu Leu Pro Gln Leu Val Val Pro Thr 
            260                 265                 270         


Tyr Asn Ala Glu Gln Leu Glu Ser Asp Val Ala Lys Glu Ile Leu Glu 
        275                 280                 285             


Tyr Thr Lys Leu Met Pro Glu Glu Arg Lys Glu Leu Leu Glu Asn Ile 
    290                 295                 300                 


Leu Ala Glu Val Asp Ser Asp Ile Ile Asp Lys Ser Leu Ser Glu Ile 
305                 310                 315                 320 


Glu Val Glu Lys Ile Ala Gln Glu Leu Glu Asn Lys Ile Arg Val Arg 
                325                 330                 335     


Asp Asp Lys Gly Asn Ser Val Pro Ile Ser Gln Leu Asn Val Gln Lys 
            340                 345                 350         


Ser Gln Leu Leu Leu Trp Thr Asn Tyr Ser Arg Lys Tyr Pro Val Ile 
        355                 360                 365             


Leu Pro Tyr Glu Val Pro Glu Lys Phe Arg Lys Ile Arg Glu Ile Pro 
    370                 375                 380                 


Met Phe Ile Ile Leu Asp Ser Gly Leu Leu Ala Asp Ile Gln Asn Phe 
385                 390                 395                 400 


Ala Thr Asn Glu Phe Arg Glu Leu Val Lys Ser Met Tyr Tyr Ser Leu 
                405                 410                 415     


Ala Lys Lys Tyr Asn Ser Leu Ala Lys Lys Ala Arg Ser Thr Asn Glu 
            420                 425                 430         


Ile Gly Leu Pro Phe Leu Asp Phe Arg Gly Lys Glu Lys Val Ile Thr 
        435                 440                 445             


Glu Asp Leu Asn Ser Asp Lys Gly Ile Ile Glu Val Val Glu Gln Val 
    450                 455                 460                 


Ser Ser Phe Met Lys Gly Lys Glu Leu Gly Leu Ala Phe Ile Ala Ala 
465                 470                 475                 480 


Arg Asn Lys Leu Ser Ser Glu Lys Phe Glu Glu Ile Lys Arg Arg Leu 
                485                 490                 495     


Phe Asn Leu Asn Val Ile Ser Gln Val Val Asn Glu Asp Thr Leu Lys 
            500                 505                 510         


Asn Lys Arg Asp Lys Tyr Asp Arg Asn Arg Leu Asp Leu Phe Val Arg 
        515                 520                 525             


His Asn Leu Leu Phe Gln Val Leu Ser Lys Leu Gly Val Lys Tyr Tyr 
    530                 535                 540                 


Val Leu Asp Tyr Arg Phe Asn Tyr Asp Tyr Ile Ile Gly Ile Asp Val 
545                 550                 555                 560 


Ala Pro Met Lys Arg Ser Glu Gly Tyr Ile Gly Gly Ser Ala Val Met 
                565                 570                 575     


Phe Asp Ser Gln Gly Tyr Ile Arg Lys Ile Val Pro Ile Lys Ile Gly 
            580                 585                 590         


Glu Gln Arg Gly Glu Ser Val Asp Met Asn Glu Phe Phe Lys Glu Met 
        595                 600                 605             


Val Asp Lys Phe Lys Glu Phe Asn Ile Lys Leu Asp Asn Lys Lys Ile 
    610                 615                 620                 


Leu Leu Leu Arg Asp Gly Arg Ile Thr Asn Asn Glu Glu Glu Gly Leu 
625                 630                 635                 640 


Lys Tyr Ile Ser Glu Met Phe Asp Ile Glu Val Val Thr Met Asp Val 
                645                 650                 655     


Ile Lys Asn His Pro Val Arg Ala Phe Ala Asn Met Lys Met Tyr Phe 
            660                 665                 670         


Asn Leu Gly Gly Ala Ile Tyr Leu Ile Pro His Lys Leu Lys Gln Ala 
        675                 680                 685             


Lys Gly Thr Pro Ile Pro Ile Lys Leu Ala Lys Lys Arg Ile Ile Lys 
    690                 695                 700                 


Asn Gly Lys Val Glu Lys Gln Ser Ile Thr Arg Gln Asp Val Leu Asp 
705                 710                 715                 720 


Ile Phe Ile Leu Thr Arg Leu Asn Tyr Gly Ser Ile Ser Ala Asp Met 
                725                 730                 735     


Arg Leu Pro Ala Pro Val His Tyr Ala His Lys Phe Ala Asn Ala Ile 
            740                 745                 750         


Arg Asn Glu Trp Lys Ile Lys Glu Glu Phe Leu Ala Glu Gly Phe Leu 
        755                 760                 765             


Tyr Phe Val 
    770     


<210>  30
<211>  125
<212>  PRT
<213>  Pyrococcus furiosus


<220>
<221>  UNSURE
<222>  (12)..(12)

<220>
<221>  UNSURE
<222>  (107)..(107)

<220>
<221>  UNSURE
<222>  (120)..(120)

<400>  30

Ile Ile Glu Val Val Glu Gln Val Ser Ser Phe Xaa Lys Gly Lys Glu 
1               5                   10                  15      


Leu Gly Leu Ala Phe Ile Ala Ala Arg Asn Lys Leu Ser Ser Glu Lys 
            20                  25                  30          


Phe Glu Glu Ile Lys Arg Arg Leu Phe Asn Leu Asn Val Ile Ser Gln 
        35                  40                  45              


Val Val Asn Glu Asp Thr Leu Lys Asn Lys Arg Asp Lys Tyr Asp Arg 
    50                  55                  60                  


Asn Arg Leu Asp Leu Phe Val Arg His Asn Leu Leu Phe Gln Val Leu 
65                  70                  75                  80  


Ser Lys Leu Gly Val Lys Tyr Tyr Val Leu Asp Tyr Arg Phe Asn Tyr 
                85                  90                  95      


Asp Tyr Ile Ile Gly Ile Asp Val Ala Pro Xaa Lys Arg Ser Glu Gly 
            100                 105                 110         


Tyr Ile Gly Gly Ser Ala Val Xaa Phe Asp Ser Gln Gly 
        115                 120                 125 


