
                                SEQUENCE LISTING

<110> Seattle Children's Hospital
      dba Seattle Children's Research Institute
      Crane, Courtney

<120> INHIBITION OF LACTATE DEHYDROGENASE 5
  (LDH-5) BINDING, INCORPORATION, INTERNALIZATION AND/OR
  ENDOCYTOSIS TO IMMUNE CELLS
  

<130> SCRI.071WO

<150> 61/977500           
<151> 2014-04-09  

<160> 24

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fragment comprising amino acids 2-51 of human
      LDH-5

<400> 1
Ala Thr Leu Lys Asp Gln Leu Ile Tyr Asn Leu Leu Lys Glu Glu Gln
 1               5                  10                  15      
Thr Pro Gln Asn Lys Ile Thr Val Val Gly Val Gly Ala Val Gly Met
            20                  25                  30          
Ala Cys Ala Ile Ser Ile Leu Met Lys Asp Leu Ala Asp Glu Leu Ala
        35                  40                  45              
Leu Val
    50  


<210> 2
<211> 241
<212> PRT
<213> Artificial Sequence

<220> 
<223> LDH-5

<400> 2
Met Ala Thr Leu Lys Asp Gln Leu Ile Tyr Asn Leu Leu Lys Glu Glu
 1               5                  10                  15      
Gln Thr Pro Gln Asn Lys Ile Thr Val Val Gly Val Gly Ala Val Gly
            20                  25                  30          
Met Ala Cys Ala Ile Ser Ile Leu Met Lys Asp Leu Ala Asp Glu Leu
        35                  40                  45              
Ala Leu Val Asp Val Ile Glu Asp Lys Leu Lys Gly Glu Met Met Asp
    50                  55                  60                  
Leu Gln His Gly Ser Leu Phe Leu Arg Thr Pro Lys Ile Val Ser Gly
65                  70                  75                  80  
Lys Asp Tyr Asn Val Thr Ala Asn Ser Lys Leu Val Ile Ile Thr Ala
                85                  90                  95      
Gly Ala Arg Gln Gln Glu Gly Glu Ser Arg Leu Asn Leu Val Gln Arg
            100                 105                 110         
Asn Val Asn Ile Phe Lys Phe Ile Ile Pro Asn Val Val Lys Tyr Ser
        115                 120                 125             
Pro Asn Cys Lys Leu Leu Ile Val Ser Asn Pro Val Asp Ile Leu Thr
    130                 135                 140                 
Tyr Val Ala Trp Lys Ile Ser Gly Phe Pro Lys Asn Arg Val Ile Gly
145                 150                 155                 160 
Ser Gly Cys Asn Leu Asp Ser Ala Arg Phe Arg Tyr Leu Met Gly Glu
                165                 170                 175     
Arg Leu Gly Val His Pro Leu Ser Cys His Gly Trp Val Leu Gly Glu
            180                 185                 190         
His Gly Asp Ser Ser Val Pro Val Trp Ser Gly Met Asn Val Ala Gly
        195                 200                 205             
Val Ser Leu Lys Thr Leu His Pro Asp Leu Gly Thr Asp Lys Asp Lys
    210                 215                 220                 
Glu Gln Trp Lys Glu Val His Lys Gln Val Val Glu Arg Val Phe Thr
225                 230                 235                 240 
Glu
    


<210> 3
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fragment comprising amino acids 2-21 of human
      LDH-5

<400> 3
Ala Thr Leu Lys Asp Gln Leu Ile Tyr Asn Leu Leu Lys Glu Glu Gln
 1               5                  10                  15      
Thr Pro Gln Asn
            20  


<210> 4
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fragment comprising amino acids 22-51 of human
      LDH-5

<400> 4
Lys Ile Thr Val Val Gly Val Gly Ala Val Gly Met Ala Cys Ala Ile
 1               5                  10                  15      
Ser Ile Leu Met Lys Asp Leu Ala Asp Glu Leu Ala Leu Val
            20                  25                  30  


<210> 5
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer for ULBP-1

<400> 5
tgcaggccag gatgtcttgt                                             20

<210> 6
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for ULBP-1

<400> 6
catccctgtt cttctcccac ttc                                         23

<210> 7
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer for ULBP-2

<400> 7
cagagcaact gcgtgacatt                                             20

<210> 8
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for ULBP-2

<400> 8
ggccacaacc ttgtcattct                                             20

<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer for ULBP-3

<400> 9
ggatttcaca cccagtggac                                             20

<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for ULBP-3

<400> 10
gcctcttctt cctgtgcatc                                             20

<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer for ULBP-4

<400> 11
ggctcaggga attcttaggg                                             20

<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for ULBP-4

<400> 12
cattttgcca ccagacacag                                             20

<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer for ULBP-5

<400> 13
caagacagtc acacccgtca                                             20

<210> 14
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for ULBP-5

<400> 14
aagccatcct gtgcagtctc                                             20

<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer for ULBP-6

<400> 15
tgacatcacc gtcatcccta                                             20

<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for ULBP-6

<400> 16
tgctcacaag acatccttgc                                             20

<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer for MICA

<400> 17
acaatgcccc agtcctccag a                                           21

<210> 18
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for MICA

<400> 18
attttagata tcgccgtagt tct                                         23

<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Forward primer for MICB

<400> 19
tgagccccac agtcttcgtt a                                           21

<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Reverse primer for MICB

<400> 20
cctgcgtttc tgcctgtcat a                                           21

<210> 21
<211> 44
<212> DNA
<213> Artificial Sequence

<220> 
<223> LDH-A 5' primer

<400> 21
cggccagaat tccgccacca tggcaactct aaaggatcag ctga                  44

<210> 22
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> LDH-A 3' primer

<400> 22
cgccgactcg agtaataaaa ttgcagctcc ttttggatc                        39

<210> 23
<211> 43
<212> DNA
<213> Artificial Sequence

<220> 
<223> LDH-B 5' primer

<400> 23
cgccgaggta cccgccacca tggcaactct taaggaaaaa ctc                   43

<210> 24
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> LDHB 3' primer

<400> 24
cgccgagaat tctaatcaca ggtcttttag gtccttctg                        39
