                         SEQUENCE LISTING

<110>  Yissum Research Development Company of the Hebrew 
       University of Jerusalem Ltd.
 
<120>  METHODS AND KITS FOR DETERMINING A PERSONALIZED TREATMENT REGIMEN
        FOR A SUBJECT SUFFERING FROM A PATHOLOGIC DISORDER

<130>  2339317

<150>  US 61/977,966
<151>  2014-04-10

<160>  112   

<170>  PatentIn version 3.5

<210>  1
<211>  685
<212>  DNA
<213>  Homo sapiens

<400>  1
ataatagggc cggtgctgcc tgccgaagcc ggcggctgag aggcagcgaa ctcatctttg       60

ccagtacagg agcttgtgcc gtggcccaca gcccacagcc cacagccatg ggctgggacc      120

tgacggtgaa gatgctggcg ggcaacgaat tccaggtgtc cctgagcagc tccatgtcgg      180

tgtcagagct gaaggcgcag atcacccaga agatcggcgt gcacgccttc cagcagcgtc      240

tggctgtcca cccgagcggt gtggcgctgc aggacagggt cccccttgcc agccagggcc      300

tgggccccgg cagcacggtc ctgctggtgg tggacaaatg cgacgaacct ctgagcatcc      360

tggtgaggaa taacaagggc cgcagcagca cctacgaggt acggctgacg cagaccgtgg      420

cccacctgaa gcagcaagtg agcgggctgg agggtgtgca ggacgacctg ttctggctga      480

ccttcgaggg gaagcccctg gaggaccagc tcccgctggg ggagtacggc ctcaagcccc      540

tgagcaccgt gttcatgaat ctgcgcctgc ggggaggcgg cacagagcct ggcgggcgga      600

gctaagggcc tccaccagca tccgagcagg atcaagggcc ggaaataaag gctgttgtaa      660

agagaaaaaa aaaaaaaaaa aaaaa                                            685


<210>  2
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Trp Asp Leu Thr Val Lys Met Leu Ala Gly Asn Glu Phe Gln 
1               5                   10                  15      


Val Ser Leu Ser Ser Ser Met Ser Val Ser Glu Leu Lys Ala Gln Ile 
            20                  25                  30          


Thr Gln Lys Ile Gly Val His Ala Phe Gln Gln Arg Leu Ala Val His 
        35                  40                  45              


Pro Ser Gly Val Ala Leu Gln Asp Arg Val Pro Leu Ala Ser Gln Gly 
    50                  55                  60                  


Leu Gly Pro Gly Ser Thr Val Leu Leu Val Val Asp Lys Cys Asp Glu 
65                  70                  75                  80  


Pro Leu Ser Ile Leu Val Arg Asn Asn Lys Gly Arg Ser Ser Thr Tyr 
                85                  90                  95      


Glu Val Arg Leu Thr Gln Thr Val Ala His Leu Lys Gln Gln Val Ser 
            100                 105                 110         


Gly Leu Glu Gly Val Gln Asp Asp Leu Phe Trp Leu Thr Phe Glu Gly 
        115                 120                 125             


Lys Pro Leu Glu Asp Gln Leu Pro Leu Gly Glu Tyr Gly Leu Lys Pro 
    130                 135                 140                 


Leu Ser Thr Val Phe Met Asn Leu Arg Leu Arg Gly Gly Gly Thr Glu 
145                 150                 155                 160 


Pro Gly Gly Arg Ser 
                165 


<210>  3
<211>  4396
<212>  DNA
<213>  Homo sapiens

<400>  3
gcaaggacac acccacagct tacaccattg gctgctgttt agctccctta tataacactg       60

tcttggggtt taaacgtaac tgaaaatcca caagacagaa tagccagatc tcagaggagc      120

ctggctaagc aaaaccctgc agaacggctg cctaatttac agcaaccatg agtacaaatg      180

gtgatgatca tcaggtcaag gatagtctgg agcaattgag atgtcacttt acatgggagt      240

tatccattga tgacgatgaa atgcctgatt tagaaaacag agtcttggat cagattgaat      300

tcctagacac caaatacagt gtgggaatac acaacctact agcctatgtg aaacacctga      360

aaggccagaa tgaggaagcc ctgaagagct taaaagaagc tgaaaactta atgcaggaag      420

aacatgacaa ccaagcaaat gtgaggagtc tggtgacctg gggcaacttt gcctggatgt      480

attaccacat gggcagactg gcagaagccc agacttacct ggacaaggtg gagaacattt      540

gcaagaagct ttcaaatccc ttccgctata gaatggagtg tccagaaata gactgtgagg      600

aaggatgggc cttgctgaag tgtggaggaa aaaattatga acgggccaag gcctgctttg      660

aaaaggtgct tgaagtggac cctgaaaacc ctgaatccag cgctgggtat gcgatctctg      720

cctatcgcct ggatggcttt aaattagcca caaaaaatca caagccattt tctttgcttc      780

ccctaaggca ggctgtccgc ttaaatccag acaatggata tattaaggtt ctccttgccc      840

tgaagcttca ggatgaagga caggaagctg aaggagaaaa gtacattgaa gaagctctag      900

ccaacatgtc ctcacagacc tatgtctttc gatatgcagc caagttttac cgaagaaaag      960

gctctgtgga taaagctctt gagttattaa aaaaggcctt gcaggaaaca cccacttctg     1020

tcttactgca tcaccagata gggctttgct acaaggcaca aatgatccaa atcaaggagg     1080

ctacaaaagg gcagcctaga gggcagaaca gagaaaagct agacaaaatg ataagatcag     1140

ccatatttca ttttgaatct gcagtggaaa aaaagcccac atttgaggtg gctcatctag     1200

acctggcaag aatgtatata gaagcaggca atcacagaaa agctgaagag aattttcaaa     1260

aattgttatg catgaaacca gtggtagaag aaacaatgca agacatacat ttccactatg     1320

gtcggtttca ggaatttcaa aagaaatctg acgtcaatgc aattatccat tatttaaaag     1380

ctataaaaat agaacaggca tcattaacaa gggataaaag tatcaattct ttgaagaaat     1440

tggttttaag gaaacttcgg agaaaggcat tagatctgga aagcttgagc ctccttgggt     1500

tcgtctacaa attggaagga aatatgaatg aagccctgga gtactatgag cgggccctga     1560

gactggctgc tgactttgag aactctgtga gacaaggtcc ttaggcaccc agatatcagc     1620

cactttcaca tttcatttca ttttatgcta acatttacta atcatctttt ctgcttactg     1680

ttttcagaaa cattataatt cactgtaatg atgtaattct tgaataataa atctgacaaa     1740

atattagttg tgttcaacaa ttagtgaaac agaatgtgtg tatgcatgta agaaagagaa     1800

atcatttgta tgagtgctat gtagtagaga aaaaatgtta gttaactttg taggaaataa     1860

aacattggac ttacactaaa tgtttaattc attcatttta ttgtgaaata aaaataaaat     1920

ccttagctcc tccaccaact gaacagaccc tcttggccaa ggagacccca gaaaccttaa     1980

aaactaagtt tcccaaccat gacaagatga gagatcattc acacctcatt atattccctc     2040

ccttgctaac tgccattgga ctttttccac tgagttaaac agaaacccat ggaaaacaaa     2100

gaacagaaga ctcactcctt ggctgacttc acctagctca ctccacgtag cgccacagcc     2160

agactcccct cccctcttgc ggtttccaca tgacaactga tcagccttcc ctcctgataa     2220

gtgaccactg cccacagact ggttctggcc agtccatgga ggctgcacac agggtgcctc     2280

tatgtccttt gtttcacctt ttgatataga aaggctaatt ttgctgtatt ttaatgttaa     2340

gtctccacca cagagtgaac acagaatgca tgtgacatac atgtttacat accactattg     2400

tgtgactgcc cctcatgaat attcatagcc ccccataacc tgttaactat gtgtgtctag     2460

ccaatccacc aaccataaaa cttctgtaat accctccctt cctccaagag cctgcttttg     2520

gttgctgtgg taggctctgc ttcccaggct gcaggttgca ggagaggagg ctgcagtggc     2580

tcacgcctgt aatctcagca cttcgatggg acgaggcagg cagatcacct gaacccagga     2640

gttcgagagc agccttggca atggcaaaac caaccgtctc tacaaaaaat gcaaaaactt     2700

agctgggtgt ggtggcatgc acctgtagct tcagttccag ctactcagga ggctgaggtg     2760

agtggactgc tggagccagg gagttcgagg ctgcagtgtc gagatcttgc cactgcactc     2820

cattctggat gatagaacga gaccccatct caaaaaaaaa aaaagttctc tccaattgta     2880

tatagcttgt gattttatgt caacactatc aataaatagc tttcagtgca agaaaccaaa     2940

aatactgtaa taaacaggca catattcttc ccaaacctca tgcagtttac aatctagtga     3000

gagacacaga tagcagtaca gagtcaatta aaggttagtt ttcttcatga agatgtttta     3060

attttaattc aatgtgaaag ggttccaagg agtttatctt gttttatgcc attttatttg     3120

aagcactact tactaagtca tttgctgata ttaatctagt taaatcaaga aatattacat     3180

gaaaatgttg ctaaatcaga gatcatgggt aacaatcacc tttgattatg aataatcata     3240

ttttattgaa aggcaaggca caacaaataa taagaaggaa aaaataaata agcaatgtta     3300

ttgatctttc attctgtata tgttttgggg ggaatatact agtttctttt agtggctgta     3360

acaaattacc acaaacttgg tgacttaaaa tttcacagat ttactctttc ttacagttct     3420

ggaggtcaga agtctgaaat gggtttcaat gagccaaagt caaggtattg atgacgctac     3480

actcctccgg aggctctagg cagatagcct tttccagctt ccagaggctg cctgaattct     3540

ttcatccatc ttaaaaacca acagtgtagt agcctcaaat ctctctctct gcttccttct     3600

tcacatctcc ttctctcctc tgactctttt gcctctttct tctaaggacg caccaggtcc     3660

acctgcataa tccagaataa ttgccccatc cgcaaatcct taatttaata acatctgcaa     3720

agtccctttt gctatgtaaa gtagcatgtt cacaggttct ggagacttgg ccatggatac     3780

gattgcgggg ggggcattat tcttaccaca gagcacccca agaaaatctc caaattttgg     3840

gcttccaatc cattttgctt caattattta atatttttac tccttccagt agatactgat     3900

ttcatccatt gcccttaaga aggtaggaca gagattatgg cacatctcac attaaatgct     3960

atattttcgt tggaaataca ttttttgctt caacttttat tttaaattca agggtacatg     4020

tgcaggatgt tcaggtttgt tacacaggta aacgtgtgcc atggcggttt gctgaacaga     4080

tcatcccatc accaacagat catcccattg agaggtgaag ccggctgggc ttctgggttg     4140

ggtggggact tggagaactt ttctgtctag ctaaagtatt gtaaaatgga ccagtcaaca     4200

ctctgtaaaa tggaccaatc agctctctgt aaaatggacc aatcagcagg atgtgggtgg     4260

ggccaagtaa gggaataaaa gcaggccacc cgagctggca gcggcaaccc gctcgggtcc     4320

ccttccatgc tgtggaagtt ttgttctttc gctctttcaa taaatcttgc tgctgctcaa     4380

aaaaaaaaaa aaaaaa                                                     4396


<210>  4
<211>  478
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Thr Asn Gly Asp Asp His Gln Val Lys Asp Ser Leu Glu Gln 
1               5                   10                  15      


Leu Arg Cys His Phe Thr Trp Glu Leu Ser Ile Asp Asp Asp Glu Met 
            20                  25                  30          


Pro Asp Leu Glu Asn Arg Val Leu Asp Gln Ile Glu Phe Leu Asp Thr 
        35                  40                  45              


Lys Tyr Ser Val Gly Ile His Asn Leu Leu Ala Tyr Val Lys His Leu 
    50                  55                  60                  


Lys Gly Gln Asn Glu Glu Ala Leu Lys Ser Leu Lys Glu Ala Glu Asn 
65                  70                  75                  80  


Leu Met Gln Glu Glu His Asp Asn Gln Ala Asn Val Arg Ser Leu Val 
                85                  90                  95      


Thr Trp Gly Asn Phe Ala Trp Met Tyr Tyr His Met Gly Arg Leu Ala 
            100                 105                 110         


Glu Ala Gln Thr Tyr Leu Asp Lys Val Glu Asn Ile Cys Lys Lys Leu 
        115                 120                 125             


Ser Asn Pro Phe Arg Tyr Arg Met Glu Cys Pro Glu Ile Asp Cys Glu 
    130                 135                 140                 


Glu Gly Trp Ala Leu Leu Lys Cys Gly Gly Lys Asn Tyr Glu Arg Ala 
145                 150                 155                 160 


Lys Ala Cys Phe Glu Lys Val Leu Glu Val Asp Pro Glu Asn Pro Glu 
                165                 170                 175     


Ser Ser Ala Gly Tyr Ala Ile Ser Ala Tyr Arg Leu Asp Gly Phe Lys 
            180                 185                 190         


Leu Ala Thr Lys Asn His Lys Pro Phe Ser Leu Leu Pro Leu Arg Gln 
        195                 200                 205             


Ala Val Arg Leu Asn Pro Asp Asn Gly Tyr Ile Lys Val Leu Leu Ala 
    210                 215                 220                 


Leu Lys Leu Gln Asp Glu Gly Gln Glu Ala Glu Gly Glu Lys Tyr Ile 
225                 230                 235                 240 


Glu Glu Ala Leu Ala Asn Met Ser Ser Gln Thr Tyr Val Phe Arg Tyr 
                245                 250                 255     


Ala Ala Lys Phe Tyr Arg Arg Lys Gly Ser Val Asp Lys Ala Leu Glu 
            260                 265                 270         


Leu Leu Lys Lys Ala Leu Gln Glu Thr Pro Thr Ser Val Leu Leu His 
        275                 280                 285             


His Gln Ile Gly Leu Cys Tyr Lys Ala Gln Met Ile Gln Ile Lys Glu 
    290                 295                 300                 


Ala Thr Lys Gly Gln Pro Arg Gly Gln Asn Arg Glu Lys Leu Asp Lys 
305                 310                 315                 320 


Met Ile Arg Ser Ala Ile Phe His Phe Glu Ser Ala Val Glu Lys Lys 
                325                 330                 335     


Pro Thr Phe Glu Val Ala His Leu Asp Leu Ala Arg Met Tyr Ile Glu 
            340                 345                 350         


Ala Gly Asn His Arg Lys Ala Glu Glu Asn Phe Gln Lys Leu Leu Cys 
        355                 360                 365             


Met Lys Pro Val Val Glu Glu Thr Met Gln Asp Ile His Phe His Tyr 
    370                 375                 380                 


Gly Arg Phe Gln Glu Phe Gln Lys Lys Ser Asp Val Asn Ala Ile Ile 
385                 390                 395                 400 


His Tyr Leu Lys Ala Ile Lys Ile Glu Gln Ala Ser Leu Thr Arg Asp 
                405                 410                 415     


Lys Ser Ile Asn Ser Leu Lys Lys Leu Val Leu Arg Lys Leu Arg Arg 
            420                 425                 430         


Lys Ala Leu Asp Leu Glu Ser Leu Ser Leu Leu Gly Phe Val Tyr Lys 
        435                 440                 445             


Leu Glu Gly Asn Met Asn Glu Ala Leu Glu Tyr Tyr Glu Arg Ala Leu 
    450                 455                 460                 


Arg Leu Ala Ala Asp Phe Glu Asn Ser Val Arg Gln Gly Pro 
465                 470                 475             


<210>  5
<211>  3505
<212>  DNA
<213>  Homo sapiens

<400>  5
agtttcactt tcccttttgt aacgtcagct gaagggaaac aaacaaaaag gaaccagagg       60

ccacttgtat atataggtct cttcagcatt tattggtggc agaagaggaa gatttctgaa      120

gagtgcagct gcctgaaccg agccctgccg aacagctgag aattgcactg caaccatgag      180

tgagaacaat aagaattcct tggagagcag cctacggcaa ctaaaatgcc atttcacctg      240

gaacttgatg gagggagaaa actccttgga tgattttgaa gacaaagtat tttaccggac      300

tgagtttcag aatcgtgaat tcaaagccac aatgtgcaac ctactggcct atctaaagca      360

cctcaaaggg caaaacgagg cagccctgga atgcttacgt aaagctgaag agttaatcca      420

gcaagagcat gctgaccagg cagaaatcag aagtctggtc acctggggaa actatgcctg      480

ggtctactat cacatgggcc gactctcaga cgttcagatt tatgtagaca aggtgaaaca      540

tgtctgtgag aagttttcca gtccctatag aattgagagt ccagagcttg actgtgagga      600

agggtggaca cggttaaagt gtggaggaaa ccaaaatgaa agagcgaagg tgtgctttga      660

gaaggctctg gaaaagaagc caaagaaccc agaattcacc tctggactgg caatagcaag      720

ctaccgtctg gacaactggc caccatctca gaacgccatt gaccctctga ggcaagccat      780

tcggctgaat cctgacaacc agtaccttaa agtcctcctg gctctgaagc ttcataagat      840

gcgtgaagaa ggtgaagagg aaggtgaagg agagaagtta gttgaagaag ccttggagaa      900

agccccaggt gtaacagatg ttcttcgcag tgcagccaag ttttatcgaa gaaaagatga      960

gccagacaaa gcgattgaac tgcttaaaaa ggctttagaa tacataccaa acaatgccta     1020

cctgcattgc caaattgggt gctgctatag ggcaaaagtc ttccaagtaa tgaatctaag     1080

agagaatgga atgtatggga aaagaaagtt actggaacta ataggacacg ctgtggctca     1140

tctgaagaaa gctgatgagg ccaatgataa tctcttccgt gtctgttcca ttcttgccag     1200

cctccatgct ctagcagatc agtatgaaga cgcagagtat tacttccaaa aggaattcag     1260

taaagagctt actcctgtag cgaaacaact gctccatctg cggtatggca actttcagct     1320

gtaccaaatg aagtgtgaag acaaggccat ccaccacttt atagagggtg taaaaataaa     1380

ccagaaatca agggagaaag aaaagatgaa agacaaactg caaaaaattg ccaaaatgcg     1440

actttctaaa aatggagcag attctgaggc tttgcatgtc ttggcattcc ttcaggagct     1500

gaatgaaaaa atgcaacaag cagatgaaga ctctgagagg ggtttggagt ctggaagcct     1560

catcccttca gcatcaagct ggaatgggga atgaagaata gagatgtggt gcccactagg     1620

ctactgctga aagggagctg aaattcctcc accaagttgg tattcaaaat atgtaatgac     1680

tggtatggca aaagattgga ctaagacact ggccatacca ctggacaggg ttatgttaac     1740

acctgaattg ctgggtcttg agagagccca aggagttctg ggagagggac cagattgggg     1800

ggtaggtcca cgggcttggt gatagaatta tttctcgatt gacttcttga gtgcaatttg     1860

aactgtaaca tttgcttagt cacctttagt ggagtaatct actgggcttg tttctatatt     1920

tatataaagc agccaaatcc ttcatgtaat attgaagtcc atttttgcaa tgttgttcca     1980

tacttggagt cattttgcat cccatagagg ttagtcctgc atagccagta atgtgctaag     2040

ttcatccaaa agctggcgga ccaaagtcta aatagggctc agtatccccc atcgcttatc     2100

tctgcctcct tcctcctcct tcccagtcta tcatcaacct tgagtattct acacaatgtg     2160

aattcaagtg cctgattaat tgaggtggca acatagtttg agacgagggc agagaacagg     2220

aagatacata gctagaagcg acgggtacaa aaagcaatgt gtacaagaag actttcagca     2280

agtatacaga gagttcacct ctactctgcc ctcctcatag tcataatgta gcaagtaaag     2340

aatgagaatg gattctgtac aatacactag aaaccaacat aatgtatttc tttaaaacct     2400

gtgtgaaaaa ataaatgttc caccagtagg gataggggaa aagtaaccaa aagagagaaa     2460

gagaaaggaa tgctggttta tctttgtaga ttgtaatcga atggagaaat ttgcagtatt     2520

ttagccacta ttaggaattt tttttttttg taaaatgaag actgaactct gttcaaatgc     2580

tttcatgaac ctggtttgag acggtaggaa agcaacaaaa cgtgggaacc tggtgactaa     2640

gggcctggtg caaggacttg ggaaatgtca ttgataatag atggtggggt tttcccccct     2700

ttagaaatgt tggatattaa gtgatataaa cacttctttt aactccgaaa atcttctgag     2760

aaatcacaaa attcacggta tgcttggaac gattgagatt ttctaggtag atgctgaata     2820

gcctagacat caaagttggt gtgaaccaaa atagagtcag ctgacccagc atcagccaca     2880

ctctgggttg gaaaatgttt gcctgttgga attaatttaa gcttaagtat atatcaacat     2940

tattttattg tgcaattaaa acaatacaaa ttcatggttt tttaaagtta aaaattctaa     3000

ccactgtaac aacagttttt gtgttatttt ctgtattaaa catcttgttg cacgcatttg     3060

aggtcatcag ggtgcaaaat ttgtattcct gaaaatgtca tatattttca ttaataaata     3120

acctaaatat gataaaacat aaagcagtgt tctggttcat ctggaatttt gctgtacttt     3180

aaatctttca gactcagcta ctgataaatg aaacgttaca caggtgtgaa ccaaatccaa     3240

ataacctcga ctggtctact atcataatca cctgaacaga acaaaacttt ttcctcagct     3300

ttaagagtcc agggcttcgg ataacagctg ccatctgcca cctgctacca ttgacctacg     3360

tgaacacaga cattctgtct ccaccttgat ggtgggtggg ctgctcccct tttctttgtt     3420

aaattttgtg ctttcatcac attttctcta ttctgacctc tgttatgaga aataaaagtc     3480

actgattcca ttttaaaaaa aaaaa                                           3505


<210>  6
<211>  472
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Glu Asn Asn Lys Asn Ser Leu Glu Ser Ser Leu Arg Gln Leu 
1               5                   10                  15      


Lys Cys His Phe Thr Trp Asn Leu Met Glu Gly Glu Asn Ser Leu Asp 
            20                  25                  30          


Asp Phe Glu Asp Lys Val Phe Tyr Arg Thr Glu Phe Gln Asn Arg Glu 
        35                  40                  45              


Phe Lys Ala Thr Met Cys Asn Leu Leu Ala Tyr Leu Lys His Leu Lys 
    50                  55                  60                  


Gly Gln Asn Glu Ala Ala Leu Glu Cys Leu Arg Lys Ala Glu Glu Leu 
65                  70                  75                  80  


Ile Gln Gln Glu His Ala Asp Gln Ala Glu Ile Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Met Gly Arg Leu Ser Asp 
            100                 105                 110         


Val Gln Ile Tyr Val Asp Lys Val Lys His Val Cys Glu Lys Phe Ser 
        115                 120                 125             


Ser Pro Tyr Arg Ile Glu Ser Pro Glu Leu Asp Cys Glu Glu Gly Trp 
    130                 135                 140                 


Thr Arg Leu Lys Cys Gly Gly Asn Gln Asn Glu Arg Ala Lys Val Cys 
145                 150                 155                 160 


Phe Glu Lys Ala Leu Glu Lys Lys Pro Lys Asn Pro Glu Phe Thr Ser 
                165                 170                 175     


Gly Leu Ala Ile Ala Ser Tyr Arg Leu Asp Asn Trp Pro Pro Ser Gln 
            180                 185                 190         


Asn Ala Ile Asp Pro Leu Arg Gln Ala Ile Arg Leu Asn Pro Asp Asn 
        195                 200                 205             


Gln Tyr Leu Lys Val Leu Leu Ala Leu Lys Leu His Lys Met Arg Glu 
    210                 215                 220                 


Glu Gly Glu Glu Glu Gly Glu Gly Glu Lys Leu Val Glu Glu Ala Leu 
225                 230                 235                 240 


Glu Lys Ala Pro Gly Val Thr Asp Val Leu Arg Ser Ala Ala Lys Phe 
                245                 250                 255     


Tyr Arg Arg Lys Asp Glu Pro Asp Lys Ala Ile Glu Leu Leu Lys Lys 
            260                 265                 270         


Ala Leu Glu Tyr Ile Pro Asn Asn Ala Tyr Leu His Cys Gln Ile Gly 
        275                 280                 285             


Cys Cys Tyr Arg Ala Lys Val Phe Gln Val Met Asn Leu Arg Glu Asn 
    290                 295                 300                 


Gly Met Tyr Gly Lys Arg Lys Leu Leu Glu Leu Ile Gly His Ala Val 
305                 310                 315                 320 


Ala His Leu Lys Lys Ala Asp Glu Ala Asn Asp Asn Leu Phe Arg Val 
                325                 330                 335     


Cys Ser Ile Leu Ala Ser Leu His Ala Leu Ala Asp Gln Tyr Glu Asp 
            340                 345                 350         


Ala Glu Tyr Tyr Phe Gln Lys Glu Phe Ser Lys Glu Leu Thr Pro Val 
        355                 360                 365             


Ala Lys Gln Leu Leu His Leu Arg Tyr Gly Asn Phe Gln Leu Tyr Gln 
    370                 375                 380                 


Met Lys Cys Glu Asp Lys Ala Ile His His Phe Ile Glu Gly Val Lys 
385                 390                 395                 400 


Ile Asn Gln Lys Ser Arg Glu Lys Glu Lys Met Lys Asp Lys Leu Gln 
                405                 410                 415     


Lys Ile Ala Lys Met Arg Leu Ser Lys Asn Gly Ala Asp Ser Glu Ala 
            420                 425                 430         


Leu His Val Leu Ala Phe Leu Gln Glu Leu Asn Glu Lys Met Gln Gln 
        435                 440                 445             


Ala Asp Glu Asp Ser Glu Arg Gly Leu Glu Ser Gly Ser Leu Ile Pro 
    450                 455                 460                 


Ser Ala Ser Ser Trp Asn Gly Glu 
465                 470         


<210>  7
<211>  2464
<212>  DNA
<213>  Homo sapiens

<400>  7
actttccttt cccctttcat aaaagcacag acctaacagc accctgggtg gaaacctctt       60

cagcatttgc ttggaatcag taagctaaaa acaaaatcaa ccgggacccc agcttttcag      120

aactgcaggg aaacagccat catgagtgag gtcaccaaga attccctgga gaaaatcctt      180

ccacagctga aatgccattt cacctggaac ttattcaagg aagacagtgt ctcaagggat      240

ctagaagata gagtgtgtaa ccagattgaa tttttaaaca ctgagttcaa agctacaatg      300

tacaacttgt tggcctacat aaaacaccta gatggtaaca acgaggcagc cctggaatgc      360

ttacggcaag ctgaagagtt aatccagcaa gaacatgctg accaagcaga aatcagaagt      420

ctagtcactt ggggaaacta cgcctgggtc tactatcact tgggcagact ctcagatgct      480

cagatttatg tagataaggt gaaacaaacc tgcaagaaat tttcaaatcc atacagtatt      540

gagtattctg aacttgactg tgaggaaggg tggacacaac tgaagtgtgg aagaaatgaa      600

agggcgaagg tgtgttttga gaaggctctg gaagaaaagc ccaacaaccc agaattctcc      660

tctggactgg caattgcgat gtaccatctg gataatcacc cagagaaaca gttctctact      720

gatgttttga agcaggccat tgagctgagt cctgataacc aatacgtcaa ggttctcttg      780

ggcctgaaac tgcagaagat gaataaagaa gctgaaggag agcagtttgt tgaagaagcc      840

ttggaaaagt ctccttgcca aacagatgtc ctccgcagtg cagccaaatt ttacagaaga      900

aaaggtgacc tagacaaagc tattgaactg tttcaacggg tgttggaatc cacaccaaac      960

aatggctacc tctatcacca gattgggtgc tgctacaagg caaaagtaag acaaatgcag     1020

aatacaggag aatctgaagc tagtggaaat aaagagatga ttgaagcact aaagcaatat     1080

gctatggact attcgaataa agctcttgag aagggactga atcctctgaa tgcatactcc     1140

gatctcgctg agttcctgga gacggaatgt tatcagacac cattcaataa ggaagtccct     1200

gatgctgaaa agcaacaatc ccatcagcgc tactgcaacc ttcagaaata taatgggaag     1260

tctgaagaca ctgctgtgca acatggttta gagggtttgt ccataagcaa aaaatcaact     1320

gacaaggaag agatcaaaga ccaaccacag aatgtatctg aaaatctgct tccacaaaat     1380

gcaccaaatt attggtatct tcaaggatta attcataagc agaatggaga tctgctgcaa     1440

gcagccaaat gttatgagaa ggaactgggc cgcctgctaa gggatgcccc ttcaggcata     1500

ggcagtattt tcctgtcagc atctgagctt gaggatggta gtgaggaaat gggccagggc     1560

gcagtcagct ccagtcccag agagctcctc tctaactcag agcaactgaa ctgagacaga     1620

ggaggaaaac agagcatcag aagcctgcag tggtggttgt gacgggtagg acgataggaa     1680

gacagggggc cccaacctgg gattgctgag cagggaagct ttgcatgttg ctctaaggta     1740

catttttaaa gagttgtttt ttggccgggc gcagtggctc atgcctgtaa tcccagcact     1800

ttgggaggcc gaggtgggcg gatcacgagg tctggagttt gagaccatcc tggctaacac     1860

agtgaaatcc cgtctctact aaaaatacaa aaaattagcc aggcgtggtg gctggcacct     1920

gtagtcccag ctacttggga ggctgaggca ggagaatggc gtgaacctgg aaggaagagg     1980

ttgcagtgag ccaagattgc gcccctgcac tccagcctgg gcaacagagc aagactccat     2040

ctcaaaaaaa aaaaaaaaaa aaaaaaagag ttgttttctc atgttcatta tagttcatta     2100

cagttacata gtccgaaggt cttacaacta atcactggta gcaataaatg cttcaggccc     2160

acatgatgct gattagttct cagttttcat tcagttcaca atataaccac cattcctgcc     2220

ctccctgcca agggtcataa atggtgactg cctaacaaca aaatttgcag tctcatctca     2280

ttttcatcca gacttctgga actcaaagat taacttttga ctaaccctgg aatatctctt     2340

atctcactta tagcttcagg catgtattta tatgtattct tgatagcaat accataatca     2400

atgtgtattc ctgatagtaa tgctacaata aatccaaaca tttcaactct gttaaaaaaa     2460

aaaa                                                                  2464


<210>  8
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ser Glu Val Thr Lys Asn Ser Leu Glu Lys Ile Leu Pro Gln Leu 
1               5                   10                  15      


Lys Cys His Phe Thr Trp Asn Leu Phe Lys Glu Asp Ser Val Ser Arg 
            20                  25                  30          


Asp Leu Glu Asp Arg Val Cys Asn Gln Ile Glu Phe Leu Asn Thr Glu 
        35                  40                  45              


Phe Lys Ala Thr Met Tyr Asn Leu Leu Ala Tyr Ile Lys His Leu Asp 
    50                  55                  60                  


Gly Asn Asn Glu Ala Ala Leu Glu Cys Leu Arg Gln Ala Glu Glu Leu 
65                  70                  75                  80  


Ile Gln Gln Glu His Ala Asp Gln Ala Glu Ile Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Leu Gly Arg Leu Ser Asp 
            100                 105                 110         


Ala Gln Ile Tyr Val Asp Lys Val Lys Gln Thr Cys Lys Lys Phe Ser 
        115                 120                 125             


Asn Pro Tyr Ser Ile Glu Tyr Ser Glu Leu Asp Cys Glu Glu Gly Trp 
    130                 135                 140                 


Thr Gln Leu Lys Cys Gly Arg Asn Glu Arg Ala Lys Val Cys Phe Glu 
145                 150                 155                 160 


Lys Ala Leu Glu Glu Lys Pro Asn Asn Pro Glu Phe Ser Ser Gly Leu 
                165                 170                 175     


Ala Ile Ala Met Tyr His Leu Asp Asn His Pro Glu Lys Gln Phe Ser 
            180                 185                 190         


Thr Asp Val Leu Lys Gln Ala Ile Glu Leu Ser Pro Asp Asn Gln Tyr 
        195                 200                 205             


Val Lys Val Leu Leu Gly Leu Lys Leu Gln Lys Met Asn Lys Glu Ala 
    210                 215                 220                 


Glu Gly Glu Gln Phe Val Glu Glu Ala Leu Glu Lys Ser Pro Cys Gln 
225                 230                 235                 240 


Thr Asp Val Leu Arg Ser Ala Ala Lys Phe Tyr Arg Arg Lys Gly Asp 
                245                 250                 255     


Leu Asp Lys Ala Ile Glu Leu Phe Gln Arg Val Leu Glu Ser Thr Pro 
            260                 265                 270         


Asn Asn Gly Tyr Leu Tyr His Gln Ile Gly Cys Cys Tyr Lys Ala Lys 
        275                 280                 285             


Val Arg Gln Met Gln Asn Thr Gly Glu Ser Glu Ala Ser Gly Asn Lys 
    290                 295                 300                 


Glu Met Ile Glu Ala Leu Lys Gln Tyr Ala Met Asp Tyr Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Glu Lys Gly Leu Asn Pro Leu Asn Ala Tyr Ser Asp Leu Ala 
                325                 330                 335     


Glu Phe Leu Glu Thr Glu Cys Tyr Gln Thr Pro Phe Asn Lys Glu Val 
            340                 345                 350         


Pro Asp Ala Glu Lys Gln Gln Ser His Gln Arg Tyr Cys Asn Leu Gln 
        355                 360                 365             


Lys Tyr Asn Gly Lys Ser Glu Asp Thr Ala Val Gln His Gly Leu Glu 
    370                 375                 380                 


Gly Leu Ser Ile Ser Lys Lys Ser Thr Asp Lys Glu Glu Ile Lys Asp 
385                 390                 395                 400 


Gln Pro Gln Asn Val Ser Glu Asn Leu Leu Pro Gln Asn Ala Pro Asn 
                405                 410                 415     


Tyr Trp Tyr Leu Gln Gly Leu Ile His Lys Gln Asn Gly Asp Leu Leu 
            420                 425                 430         


Gln Ala Ala Lys Cys Tyr Glu Lys Glu Leu Gly Arg Leu Leu Arg Asp 
        435                 440                 445             


Ala Pro Ser Gly Ile Gly Ser Ile Phe Leu Ser Ala Ser Glu Leu Glu 
    450                 455                 460                 


Asp Gly Ser Glu Glu Met Gly Gln Gly Ala Val Ser Ser Ser Pro Arg 
465                 470                 475                 480 


Glu Leu Leu Ser Asn Ser Glu Gln Leu Asn 
                485                 490 


<210>  9
<211>  2552
<212>  DNA
<213>  Homo sapiens

<400>  9
attttcctcc tcccaacgat tttaaattag tttcactttc cagtttcctc ttccttcccc       60

taaaagcaat tactcaaaaa cggagaaaac atcagctgat gcgtgcccta ctctcccacc      120

cctttatata gttccttcag tatttacttg aggcagacag gaagacttct gaagaacaaa      180

tcagcctggt caccagcttt tcggaacagc agagacacag agggcagtca tgagtgaggt      240

caccaagaat tccctggaga aaatccttcc acagctgaaa tgccatttca cctggaactt      300

attcaaggaa gacagtgtct caagggatct agaagataga gtgtgtaacc agattgaatt      360

tttaaacact gagttcaaag ctacaatgta caacttgttg gcctacataa aacacctaga      420

tggtaacaac gaggcagccc tggaatgctt acggcaagct gaagagttaa tccagcaaga      480

acatgctgac caagcagaaa tcagaagtct agtcacttgg ggaaactacg cctgggtcta      540

ctatcacttg ggcagactct cagatgctca gatttatgta gataaggtga aacaaacctg      600

caagaaattt tcaaatccat acagtattga gtattctgaa cttgactgtg aggaagggtg      660

gacacaactg aagtgtggaa gaaatgaaag ggcgaaggtg tgttttgaga aggctctgga      720

agaaaagccc aacaacccag aattctcctc tggactggca attgcgatgt accatctgga      780

taatcaccca gagaaacagt tctctactga tgttttgaag caggccattg agctgagtcc      840

tgataaccaa tacgtcaagg ttctcttggg cctgaaactg cagaagatga ataaagaagc      900

tgaaggagag cagtttgttg aagaagcctt ggaaaagtct ccttgccaaa cagatgtcct      960

ccgcagtgca gccaaatttt acagaagaaa aggtgaccta gacaaagcta ttgaactgtt     1020

tcaacgggtg ttggaatcca caccaaacaa tggctacctc tatcaccaga ttgggtgctg     1080

ctacaaggca aaagtaagac aaatgcagaa tacaggagaa tctgaagcta gtggaaataa     1140

agagatgatt gaagcactaa agcaatatgc tatggactat tcgaataaag ctcttgagaa     1200

gggactgaat cctctgaatg catactccga tctcgctgag ttcctggaga cggaatgtta     1260

tcagacacca ttcaataagg aagtccctga tgctgaaaag caacaatccc atcagcgcta     1320

ctgcaacctt cagaaatata atgggaagtc tgaagacact gctgtgcaac atggtttaga     1380

gggtttgtcc ataagcaaaa aatcaactga caaggaagag atcaaagacc aaccacagaa     1440

tgtatctgaa aatctgcttc cacaaaatgc accaaattat tggtatcttc aaggattaat     1500

tcataagcag aatggagatc tgctgcaagc agccaaatgt tatgagaagg aactgggccg     1560

cctgctaagg gatgcccctt caggcatagg cagtattttc ctgtcagcat ctgagcttga     1620

ggatggtagt gaggaaatgg gccagggcgc agtcagctcc agtcccagag agctcctctc     1680

taactcagag caactgaact gagacagagg aggaaaacag agcatcagaa gcctgcagtg     1740

gtggttgtga cgggtaggac gataggaaga cagggggccc caacctggga ttgctgagca     1800

gggaagcttt gcatgttgct ctaaggtaca tttttaaaga gttgtttttt ggccgggcgc     1860

agtggctcat gcctgtaatc ccagcacttt gggaggccga ggtgggcgga tcacgaggtc     1920

tggagtttga gaccatcctg gctaacacag tgaaatcccg tctctactaa aaatacaaaa     1980

aattagccag gcgtggtggc tggcacctgt agtcccagct acttgggagg ctgaggcagg     2040

agaatggcgt gaacctggaa ggaagaggtt gcagtgagcc aagattgcgc ccctgcactc     2100

cagcctgggc aacagagcaa gactccatct caaaaaaaaa aaaaaaaaaa aaaaagagtt     2160

gttttctcat gttcattata gttcattaca gttacatagt ccgaaggtct tacaactaat     2220

cactggtagc aataaatgct tcaggcccac atgatgctga ttagttctca gttttcattc     2280

agttcacaat ataaccacca ttcctgccct ccctgccaag ggtcataaat ggtgactgcc     2340

taacaacaaa atttgcagtc tcatctcatt ttcatccaga cttctggaac tcaaagatta     2400

acttttgact aaccctggaa tatctcttat ctcacttata gcttcaggca tgtatttata     2460

tgtattcttg atagcaatac cataatcaat gtgtattcct gatagtaatg ctacaataaa     2520

tccaaacatt tcaactctgt taaaaaaaaa aa                                   2552


<210>  10
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Glu Val Thr Lys Asn Ser Leu Glu Lys Ile Leu Pro Gln Leu 
1               5                   10                  15      


Lys Cys His Phe Thr Trp Asn Leu Phe Lys Glu Asp Ser Val Ser Arg 
            20                  25                  30          


Asp Leu Glu Asp Arg Val Cys Asn Gln Ile Glu Phe Leu Asn Thr Glu 
        35                  40                  45              


Phe Lys Ala Thr Met Tyr Asn Leu Leu Ala Tyr Ile Lys His Leu Asp 
    50                  55                  60                  


Gly Asn Asn Glu Ala Ala Leu Glu Cys Leu Arg Gln Ala Glu Glu Leu 
65                  70                  75                  80  


Ile Gln Gln Glu His Ala Asp Gln Ala Glu Ile Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Leu Gly Arg Leu Ser Asp 
            100                 105                 110         


Ala Gln Ile Tyr Val Asp Lys Val Lys Gln Thr Cys Lys Lys Phe Ser 
        115                 120                 125             


Asn Pro Tyr Ser Ile Glu Tyr Ser Glu Leu Asp Cys Glu Glu Gly Trp 
    130                 135                 140                 


Thr Gln Leu Lys Cys Gly Arg Asn Glu Arg Ala Lys Val Cys Phe Glu 
145                 150                 155                 160 


Lys Ala Leu Glu Glu Lys Pro Asn Asn Pro Glu Phe Ser Ser Gly Leu 
                165                 170                 175     


Ala Ile Ala Met Tyr His Leu Asp Asn His Pro Glu Lys Gln Phe Ser 
            180                 185                 190         


Thr Asp Val Leu Lys Gln Ala Ile Glu Leu Ser Pro Asp Asn Gln Tyr 
        195                 200                 205             


Val Lys Val Leu Leu Gly Leu Lys Leu Gln Lys Met Asn Lys Glu Ala 
    210                 215                 220                 


Glu Gly Glu Gln Phe Val Glu Glu Ala Leu Glu Lys Ser Pro Cys Gln 
225                 230                 235                 240 


Thr Asp Val Leu Arg Ser Ala Ala Lys Phe Tyr Arg Arg Lys Gly Asp 
                245                 250                 255     


Leu Asp Lys Ala Ile Glu Leu Phe Gln Arg Val Leu Glu Ser Thr Pro 
            260                 265                 270         


Asn Asn Gly Tyr Leu Tyr His Gln Ile Gly Cys Cys Tyr Lys Ala Lys 
        275                 280                 285             


Val Arg Gln Met Gln Asn Thr Gly Glu Ser Glu Ala Ser Gly Asn Lys 
    290                 295                 300                 


Glu Met Ile Glu Ala Leu Lys Gln Tyr Ala Met Asp Tyr Ser Asn Lys 
305                 310                 315                 320 


Ala Leu Glu Lys Gly Leu Asn Pro Leu Asn Ala Tyr Ser Asp Leu Ala 
                325                 330                 335     


Glu Phe Leu Glu Thr Glu Cys Tyr Gln Thr Pro Phe Asn Lys Glu Val 
            340                 345                 350         


Pro Asp Ala Glu Lys Gln Gln Ser His Gln Arg Tyr Cys Asn Leu Gln 
        355                 360                 365             


Lys Tyr Asn Gly Lys Ser Glu Asp Thr Ala Val Gln His Gly Leu Glu 
    370                 375                 380                 


Gly Leu Ser Ile Ser Lys Lys Ser Thr Asp Lys Glu Glu Ile Lys Asp 
385                 390                 395                 400 


Gln Pro Gln Asn Val Ser Glu Asn Leu Leu Pro Gln Asn Ala Pro Asn 
                405                 410                 415     


Tyr Trp Tyr Leu Gln Gly Leu Ile His Lys Gln Asn Gly Asp Leu Leu 
            420                 425                 430         


Gln Ala Ala Lys Cys Tyr Glu Lys Glu Leu Gly Arg Leu Leu Arg Asp 
        435                 440                 445             


Ala Pro Ser Gly Ile Gly Ser Ile Phe Leu Ser Ala Ser Glu Leu Glu 
    450                 455                 460                 


Asp Gly Ser Glu Glu Met Gly Gln Gly Ala Val Ser Ser Ser Pro Arg 
465                 470                 475                 480 


Glu Leu Leu Ser Asn Ser Glu Gln Leu Asn 
                485                 490 


<210>  11
<211>  4034
<212>  DNA
<213>  Homo sapiens

<400>  11
agtttctgag cgctcggcat ctgattcaat ctccagtttc ctgttcttgc tggggctggg       60

gtctctcctt taacaaagac acgccgcgcg gccgagtcca ggggctgcag aggcctggcg      120

cgcgcacgcg cacgcgcacg cccaccgcgc ggcttcccgc ggtccccggt gctgaggaga      180

gagcgatccg agggactgcg ccgcccggac ggcctgcaga gcgctgccat catgagtgaa      240

attcgtaagg acaccttgaa ggccattctg ttggagttag aatgtcattt tacatggaat      300

ttacttaagg aagacattga tctgtttgag gtagaagata caattgggca acagcttgaa      360

tttcttacca caaaatctag acttgctctt tataacctat tggcctatgt gaaacaccta      420

aaaggccaaa ataaagacgc ccttgagtgc ttggaacaag cagaagaaat aatccagcaa      480

gaacactcag acaaagaaga agtacgaagc ctggtcactt ggggaaacta tgcctgggtg      540

tattatcaca tggaccagct tgaagaagct cagaagtata caggtaagat agggaatgtc      600

tgtaagaaat tgtccagtcc ttctaactac aagttggagt gtcctgagac tgactgtgag      660

aaaggctggg cactcttgaa atttggagga aagtattatc aaaaggctaa agcggctttt      720

gagaaggctc tggaagtgga gcctgacaat ccagaattta acatcggcta tgctatcaca      780

gtgtatcggc tggatgattc tgatagagaa gggtctgtaa agagcttttc tctggggcct      840

ttgagaaagg ctgttaccct gaacccagat aacagctata ttaaggtttt tctggcactg      900

aagcttcaag atgtacatgc agaagctgaa ggggaaaagt atattgaaga aatcctggac      960

caaatatcat cccagcctta cgtccttcgt tatgcagcca agttctatag gagaaaaaat     1020

tcctggaaca aagctctcga acttttaaaa aaggccttgg aggtgacacc aacttcttct     1080

ttcctgcatc accagatggg actttgctac agggcacaaa tgatccaaat caagaaggcc     1140

acacacaaca gacctaaagg aaaggataaa ctaaaggttg atgagctgat ttcatctgct     1200

atatttcatt tcaaagcagc catggaacga gactctatgt ttgcatttgc ctacacagac     1260

ctggccaaca tgtacgctga aggaggccag tatagcaatg ctgaggacat tttccggaaa     1320

gctcttcgtc tggagaacat aaccgatgat cacaaacatc agatccatta ccactatggc     1380

cgctttcagg aatttcaccg taaatcagaa aatactgcca tccatcatta tttagaagcc     1440

ttaaaggtca aagacagatc accccttcgc accaaactga caagtgctct gaagaaattg     1500

tctaccaaga gactttgtca caatgcttta gatgtgcaga gtttaagtgc cctagggttt     1560

gtttacaagc tggaaggaga aaagaggcaa gctgctgagt actatgagaa ggcacaaaag     1620

atagatccag aaaatgcaga attcctgact gctctctgtg agctccgact ttccatttaa     1680

atacatactc taggaaatta gctctaagtt tttcccttca ttttgggttc tcctgtttgt     1740

ttttttttta ttattttaat cccttgttta ttatagagct aatatttatt gaatagttat     1800

tgtgtaccaa gcattgtgct aaatacttta tatgcattat gatgaatctt gtgcggtttt     1860

ctttcttttt ttctttttaa ttaaaatact ataatccatt gagaaatagc aatattctag     1920

ctattgtaac ttctaaaaat ggtatggcca ttagatctgt gctttttatc tctgctcttt     1980

gaatttctca tattatatag taaatatatt cctacgtaaa cctttgatac ctagatcagg     2040

aatactcttc caggagtaca aaattacatt attgatagtt aagctcttaa ttgtgtagct     2100

tgcaaaagac agcacttttt agttacagat gttttgactt tgatgaggat atttagctat     2160

caatctaata gtcacctaaa atatcttttt tgttggaaaa aagtttataa taaaaaagtt     2220

tgtcatctct agtgacttca ataaagaaaa aactagaaga ggagaaaaag gatttcctca     2280

aattttaaat atgtaacttc agggattcaa tccccaaatg tttattaagt agctagaaat     2340

aattatgtgg aaaaaaatga ataatggaaa atagtgagtc tcaaattgtt ctcttttttt     2400

ttttaactaa aacaaatctg caatgaatct agatgcaatt aattttattc cttccaacta     2460

aaattacaat atttttaggt taaaattatt gagatataaa gcagccattg ggaaattggg     2520

agaaatgata aacaaatgga aaaagaagat gtccctaacc tacacccata gattaccaag     2580

gtttcagtgt actagttttg aatctgttct gaatggagtt tttataccct caatttctgg     2640

cctttggcta ttttagcatt tcaaagtgac ttctatgaag cttttttttt aatgtgaaat     2700

tttcagaatg ttgttttttt catgtagata ctccaggaag agttaagcac tgctttcagt     2760

tttaatatcc accttgaggg gtcgctgctt gagggctctt atcccagggg actttttaat     2820

tcggatgtta cttaatgtgg cttctctaat gtagtttctt tgattaccga ctacacaatt     2880

atgtaccatc acagtattag tggaaaagta ccatgtgatt taattctcca ttcctccaat     2940

gtaactctta aaattattat gtatgtgtgt gtgttttact ttttgttttt tatcatcttt     3000

aaaatttcta ttatggtttg attattataa aaataatgaa ttctcactgt aaatttcaaa     3060

aaaaaattac aaaagtatgt gaatttaaaa atgagagcag tcctctcacc ctaccacagt     3120

tccacaccct caaggtaaac ttataactta taatttgata tgtaaacttc cagatctttt     3180

ttctatgcgt aatcagacat acatatatac tgcagtgtat ctcacgtatt aatttttaaa     3240

aatcttttgt tttacttaat tctgttttta ttattattat tattttgttt gatctattaa     3300

ggaagaacaa ggaagggaat gatctttact caagaatttc agaaagtcag cactgaagtc     3360

ctgacctatc agtagacaca tttgtccctt tcagatattt taggatattc tagcaaagca     3420

ggccatttct cccacctgaa agtacataac ttctatcact tgccacataa ttaaaagaac     3480

tcacattaag cggttactca gacagttaat catagaaaag attatttgct tcatcagttc     3540

atagaaaaga ttatttgctt catcagttaa cttgttttta taaatcaggg ctgtgttcat     3600

acacagaagg ggcctgagat ttctgcactt taaacaagct cctcctaggt gaggatgctg     3660

tggctgttct aattacattt tgagtagtaa ggtctacagc attgttcctc aaacttggct     3720

acgtattgga atcacctaaa aagttaaaac aaaacatgga tgtctgggtc ccgccccata     3780

gagaatgact taattggcat ggggtgcagt ccaggcatca tgatttttag atttcccagt     3840

tggaacttgt gcagcaaagt ttgggagcta ctgatggaca tgtgaaaagt aagtataaat     3900

ggaataaaat taattaggct aataggctta acccaggaaa tcctaagttc cttgaatatc     3960

cagtttgcat ttggactcct catcatatac ttggtatata atactctaat aaaagctgcc     4020

tgagttgaat tgta                                                       4034


<210>  12
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Glu Ile Arg Lys Asp Thr Leu Lys Ala Ile Leu Leu Glu Leu 
1               5                   10                  15      


Glu Cys His Phe Thr Trp Asn Leu Leu Lys Glu Asp Ile Asp Leu Phe 
            20                  25                  30          


Glu Val Glu Asp Thr Ile Gly Gln Gln Leu Glu Phe Leu Thr Thr Lys 
        35                  40                  45              


Ser Arg Leu Ala Leu Tyr Asn Leu Leu Ala Tyr Val Lys His Leu Lys 
    50                  55                  60                  


Gly Gln Asn Lys Asp Ala Leu Glu Cys Leu Glu Gln Ala Glu Glu Ile 
65                  70                  75                  80  


Ile Gln Gln Glu His Ser Asp Lys Glu Glu Val Arg Ser Leu Val Thr 
                85                  90                  95      


Trp Gly Asn Tyr Ala Trp Val Tyr Tyr His Met Asp Gln Leu Glu Glu 
            100                 105                 110         


Ala Gln Lys Tyr Thr Gly Lys Ile Gly Asn Val Cys Lys Lys Leu Ser 
        115                 120                 125             


Ser Pro Ser Asn Tyr Lys Leu Glu Cys Pro Glu Thr Asp Cys Glu Lys 
    130                 135                 140                 


Gly Trp Ala Leu Leu Lys Phe Gly Gly Lys Tyr Tyr Gln Lys Ala Lys 
145                 150                 155                 160 


Ala Ala Phe Glu Lys Ala Leu Glu Val Glu Pro Asp Asn Pro Glu Phe 
                165                 170                 175     


Asn Ile Gly Tyr Ala Ile Thr Val Tyr Arg Leu Asp Asp Ser Asp Arg 
            180                 185                 190         


Glu Gly Ser Val Lys Ser Phe Ser Leu Gly Pro Leu Arg Lys Ala Val 
        195                 200                 205             


Thr Leu Asn Pro Asp Asn Ser Tyr Ile Lys Val Phe Leu Ala Leu Lys 
    210                 215                 220                 


Leu Gln Asp Val His Ala Glu Ala Glu Gly Glu Lys Tyr Ile Glu Glu 
225                 230                 235                 240 


Ile Leu Asp Gln Ile Ser Ser Gln Pro Tyr Val Leu Arg Tyr Ala Ala 
                245                 250                 255     


Lys Phe Tyr Arg Arg Lys Asn Ser Trp Asn Lys Ala Leu Glu Leu Leu 
            260                 265                 270         


Lys Lys Ala Leu Glu Val Thr Pro Thr Ser Ser Phe Leu His His Gln 
        275                 280                 285             


Met Gly Leu Cys Tyr Arg Ala Gln Met Ile Gln Ile Lys Lys Ala Thr 
    290                 295                 300                 


His Asn Arg Pro Lys Gly Lys Asp Lys Leu Lys Val Asp Glu Leu Ile 
305                 310                 315                 320 


Ser Ser Ala Ile Phe His Phe Lys Ala Ala Met Glu Arg Asp Ser Met 
                325                 330                 335     


Phe Ala Phe Ala Tyr Thr Asp Leu Ala Asn Met Tyr Ala Glu Gly Gly 
            340                 345                 350         


Gln Tyr Ser Asn Ala Glu Asp Ile Phe Arg Lys Ala Leu Arg Leu Glu 
        355                 360                 365             


Asn Ile Thr Asp Asp His Lys His Gln Ile His Tyr His Tyr Gly Arg 
    370                 375                 380                 


Phe Gln Glu Phe His Arg Lys Ser Glu Asn Thr Ala Ile His His Tyr 
385                 390                 395                 400 


Leu Glu Ala Leu Lys Val Lys Asp Arg Ser Pro Leu Arg Thr Lys Leu 
                405                 410                 415     


Thr Ser Ala Leu Lys Lys Leu Ser Thr Lys Arg Leu Cys His Asn Ala 
            420                 425                 430         


Leu Asp Val Gln Ser Leu Ser Ala Leu Gly Phe Val Tyr Lys Leu Glu 
        435                 440                 445             


Gly Glu Lys Arg Gln Ala Ala Glu Tyr Tyr Glu Lys Ala Gln Lys Ile 
    450                 455                 460                 


Asp Pro Glu Asn Ala Glu Phe Leu Thr Ala Leu Cys Glu Leu Arg Leu 
465                 470                 475                 480 


Ser Ile 
        


<210>  13
<211>  1673
<212>  DNA
<213>  Homo sapiens

<400>  13
tcccttctga ggaaacgaaa ccaacagcag tccaagctca gtcagcagaa gagataaaag       60

caaacaggtc tgggaggcag ttctgttgcc actctctctc ctgtcaatga tggatctcag      120

aaatacccca gccaaatctc tggacaagtt cattgaagac tatctcttgc cagacacgtg      180

tttccgcatg caaatcaacc atgccattga catcatctgt gggttcctga aggaaaggtg      240

cttccgaggt agctcctacc ctgtgtgtgt gtccaaggtg gtaaagggtg gctcctcagg      300

caagggcacc accctcagag gccgatctga cgctgacctg gttgtcttcc tcagtcctct      360

caccactttt caggatcagt taaatcgccg gggagagttc atccaggaaa ttaggagaca      420

gctggaagcc tgtcaaagag agagagcatt ttccgtgaag tttgaggtcc aggctccacg      480

ctggggcaac ccccgtgcgc tcagcttcgt actgagttcg ctccagctcg gggagggggt      540

ggagttcgat gtgctgcctg cctttgatgc cctgggtcag ttgactggcg gctataaacc      600

taacccccaa atctatgtca agctcatcga ggagtgcacc gacctgcaga aagagggcga      660

gttctccacc tgcttcacag aactacagag agacttcctg aagcagcgcc ccaccaagct      720

caagagcctc atccgcctag tcaagcactg gtaccaaaat tgtaagaaga agcttgggaa      780

gctgccacct cagtatgccc tggagctcct gacggtctat gcttgggagc gagggagcat      840

gaaaacacat ttcaacacag cccagggatt tcggacggtc ttggaattag tcataaacta      900

ccagcaactc tgcatctact ggacaaagta ttatgacttt aaaaacccca ttattgaaaa      960

gtacctgaga aggcagctca cgaaacccag gcctgtgatc ctggacccgg cggaccctac     1020

aggaaacttg ggtggtggag acccaaaggg ttggaggcag ctggcacaag aggctgaggc     1080

ctggctgaat tacccatgct ttaagaattg ggatgggtcc ccagtgagct cctggattct     1140

gctggctgaa agcaacagtg cagacgatga gaccgacgat cccaggaggt atcagaaata     1200

tggttacatt ggaacacatg agtaccctca tttctctcat agacccagca cactccaggc     1260

agcatccacc ccacaggcag aagaggactg gacctgcacc atcctctgaa tgccagtgca     1320

tcttggggga aagggctcca gtgttatctg gaccagttcc ttcattttca ggtgggactc     1380

ttgatccaga gaggacaaag ctcctcagtg agctggtgta taatccagga cagaacccag     1440

gtctcctgac tcctggcctt ctatgccctc tatcctatca tagataacat tctccacagc     1500

ctcacttcat tccacctatt ctctgaaaat attccctgag agagaacaga gagatttaga     1560

taagagaatg aaattccagc cttgactttc ttctgtgcac ctgatgggag ggtaatgtct     1620

aatgtattat caataacaat aaaaataaag caaataccat ttaaaaaaaa aaa            1673


<210>  14
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile 
1               5                   10                  15      


Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Asn His 
            20                  25                  30          


Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly 
        35                  40                  45              


Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser 
    50                  55                  60                  


Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val 
65                  70                  75                  80  


Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly 
                85                  90                  95      


Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu 
            100                 105                 110         


Arg Ala Phe Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Gly Asn 
        115                 120                 125             


Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly 
    130                 135                 140                 


Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr 
145                 150                 155                 160 


Gly Gly Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu 
                165                 170                 175     


Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu 
            180                 185                 190         


Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu 
        195                 200                 205             


Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly 
    210                 215                 220                 


Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp 
225                 230                 235                 240 


Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg 
                245                 250                 255     


Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp 
            260                 265                 270         


Thr Lys Tyr Tyr Asp Phe Lys Asn Pro Ile Ile Glu Lys Tyr Leu Arg 
        275                 280                 285             


Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro 
    290                 295                 300                 


Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala 
305                 310                 315                 320 


Gln Glu Ala Glu Ala Trp Leu Asn Tyr Pro Cys Phe Lys Asn Trp Asp 
                325                 330                 335     


Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Ala Glu Ser Asn Ser Ala 
            340                 345                 350         


Asp Asp Glu Thr Asp Asp Pro Arg Arg Tyr Gln Lys Tyr Gly Tyr Ile 
        355                 360                 365             


Gly Thr His Glu Tyr Pro His Phe Ser His Arg Pro Ser Thr Leu Gln 
    370                 375                 380                 


Ala Ala Ser Thr Pro Gln Ala Glu Glu Asp Trp Thr Cys Thr Ile Leu 
385                 390                 395                 400 


<210>  15
<211>  1470
<212>  DNA
<213>  Homo sapiens

<400>  15
tcccttctga ggaaacgaaa ccaacagcag tccaagctca gtcagcagaa gagataaaag       60

caaacaggtc tgggaggcag ttctgttgcc actctctctc ctgtcaatga tggatctcag      120

aaatacccca gccaaatctc tggacaagtt cattgaagac tatctcttgc cagacacgtg      180

tttccgcatg caaatcaacc atgccattga catcatctgt gggttcctga aggaaaggtg      240

cttccgaggt agctcctacc ctgtgtgtgt gtccaaggtg gtaaagggtg gctcctcagg      300

caagggcacc accctcagag gccgatctga cgctgacctg gttgtcttcc tcagtcctct      360

caccactttt caggatcagt taaatcgccg gggagagttc atccaggaaa ttaggagaca      420

gctggaagcc tgtcaaagag agagagcatt ttccgtgaag tttgaggtcc aggctccacg      480

ctggggcaac ccccgtgcgc tcagcttcgt actgagttcg ctccagctcg gggagggggt      540

ggagttcgat gtgctgcctg cctttgatgc cctgggtcag ttgactggcg gctataaacc      600

taacccccaa atctatgtca agctcatcga ggagtgcacc gacctgcaga aagagggcga      660

gttctccacc tgcttcacag aactacagag agacttcctg aagcagcgcc ccaccaagct      720

caagagcctc atccgcctag tcaagcactg gtaccaaaat tgtaagaaga agcttgggaa      780

gctgccacct cagtatgccc tggagctcct gacggtctat gcttgggagc gagggagcat      840

gaaaacacat ttcaacacag cccagggatt tcggacggtc ttggaattag tcataaacta      900

ccagcaactc tgcatctact ggacaaagta ttatgacttt aaaaacccca ttattgaaaa      960

gtacctgaga aggcagctca cgaaacccag gcctgtgatc ctggacccgg cggaccctac     1020

aggaaacttg ggtggtggag acccaaaggg ttggaggcag ctggcacaag aggctgaggc     1080

ctggctgaat tacccatgct ttaagaattg ggatgggtcc ccagtgagct cctggattct     1140

gctggtgaga cctcctgctt cctccctgcc attcatccct gcccctctcc atgaagcttg     1200

agacatatag ctggagacca ttctttccaa agaacttacc tcttgccaaa ggccatttat     1260

attcatatag tgacaggctg tgctccatat tttacagtca ttttggtcac aatcgagggt     1320

ttctggaatt ttcacatccc ttgtccagaa ttcattcccc taagagtaat aataaataat     1380

ctctaacacc atttattgac tgtctgcttc gggctcaggt tctgtcctaa gccctttaat     1440

atgcactctc tcattaaata gtcacaacaa                                      1470


<210>  16
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile 
1               5                   10                  15      


Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Asn His 
            20                  25                  30          


Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly 
        35                  40                  45              


Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser 
    50                  55                  60                  


Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val 
65                  70                  75                  80  


Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly 
                85                  90                  95      


Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu 
            100                 105                 110         


Arg Ala Phe Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Gly Asn 
        115                 120                 125             


Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly 
    130                 135                 140                 


Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr 
145                 150                 155                 160 


Gly Gly Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu 
                165                 170                 175     


Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu 
            180                 185                 190         


Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu 
        195                 200                 205             


Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly 
    210                 215                 220                 


Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp 
225                 230                 235                 240 


Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg 
                245                 250                 255     


Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp 
            260                 265                 270         


Thr Lys Tyr Tyr Asp Phe Lys Asn Pro Ile Ile Glu Lys Tyr Leu Arg 
        275                 280                 285             


Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro 
    290                 295                 300                 


Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala 
305                 310                 315                 320 


Gln Glu Ala Glu Ala Trp Leu Asn Tyr Pro Cys Phe Lys Asn Trp Asp 
                325                 330                 335     


Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Val Arg Pro Pro Ala Ser 
            340                 345                 350         


Ser Leu Pro Phe Ile Pro Ala Pro Leu His Glu Ala 
        355                 360                 


<210>  17
<211>  1575
<212>  DNA
<213>  Homo sapiens

<400>  17
tcccttctga ggaaacgaaa ccaacagcag tccaagctca gtcagcagaa gagataaaag       60

caaacaggtc tgggaggcag ttctgttgcc actctctctc ctgtcaatga tggatctcag      120

aaatacccca gccaaatctc tggacaagtt cattgaagac tatctcttgc cagacacgtg      180

tttccgcatg caaatcaacc atgccattga catcatctgt gggttcctga aggaaaggtg      240

cttccgaggt agctcctacc ctgtgtgtgt gtccaaggtg gtaaagggtg gctcctcagg      300

caagggcacc accctcagag gccgatctga cgctgacctg gttgtcttcc tcagtcctct      360

caccactttt caggatcagt taaatcgccg gggagagttc atccaggaaa ttaggagaca      420

gctggaagcc tgtcaaagag agagagcatt ttccgtgaag tttgaggtcc aggctccacg      480

ctggggcaac ccccgtgcgc tcagcttcgt actgagttcg ctccagctcg gggagggggt      540

ggagttcgat gtgctgcctg cctttgatgc cctgggtcag ttgactggcg gctataaacc      600

taacccccaa atctatgtca agctcatcga ggagtgcacc gacctgcaga aagagggcga      660

gttctccacc tgcttcacag aactacagag agacttcctg aagcagcgcc ccaccaagct      720

caagagcctc atccgcctag tcaagcactg gtaccaaaat tgtaagaaga agcttgggaa      780

gctgccacct cagtatgccc tggagctcct gacggtctat gcttgggagc gagggagcat      840

gaaaacacat ttcaacacag cccagggatt tcggacggtc ttggaattag tcataaacta      900

ccagcaactc tgcatctact ggacaaagta ttatgacttt aaaaacccca ttattgaaaa      960

gtacctgaga aggcagctca cgaaacccag gcctgtgatc ctggacccgg cggaccctac     1020

aggaaacttg ggtggtggag acccaaaggg ttggaggcag ctggcacaag aggctgaggc     1080

ctggctgaat tacccatgct ttaagaattg ggatgggtcc ccagtgagct cctggattct     1140

gctgacccag cacactccag gcagcatcca ccccacaggc agaagaggac tggacctgca     1200

ccatcctctg aatgccagtg catcttgggg gaaagggctc cagtgttatc tggaccagtt     1260

ccttcatttt caggtgggac tcttgatcca gagaggacaa agctcctcag tgagctggtg     1320

tataatccag gacagaaccc aggtctcctg actcctggcc ttctatgccc tctatcctat     1380

catagataac attctccaca gcctcacttc attccaccta ttctctgaaa atattccctg     1440

agagagaaca gagagattta gataagagaa tgaaattcca gccttgactt tcttctgtgc     1500

acctgatggg agggtaatgt ctaatgtatt atcaataaca ataaaaataa agcaaatacc     1560

atttaaaaaa aaaaa                                                      1575


<210>  18
<211>  414
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Met Asp Leu Arg Asn Thr Pro Ala Lys Ser Leu Asp Lys Phe Ile 
1               5                   10                  15      


Glu Asp Tyr Leu Leu Pro Asp Thr Cys Phe Arg Met Gln Ile Asn His 
            20                  25                  30          


Ala Ile Asp Ile Ile Cys Gly Phe Leu Lys Glu Arg Cys Phe Arg Gly 
        35                  40                  45              


Ser Ser Tyr Pro Val Cys Val Ser Lys Val Val Lys Gly Gly Ser Ser 
    50                  55                  60                  


Gly Lys Gly Thr Thr Leu Arg Gly Arg Ser Asp Ala Asp Leu Val Val 
65                  70                  75                  80  


Phe Leu Ser Pro Leu Thr Thr Phe Gln Asp Gln Leu Asn Arg Arg Gly 
                85                  90                  95      


Glu Phe Ile Gln Glu Ile Arg Arg Gln Leu Glu Ala Cys Gln Arg Glu 
            100                 105                 110         


Arg Ala Phe Ser Val Lys Phe Glu Val Gln Ala Pro Arg Trp Gly Asn 
        115                 120                 125             


Pro Arg Ala Leu Ser Phe Val Leu Ser Ser Leu Gln Leu Gly Glu Gly 
    130                 135                 140                 


Val Glu Phe Asp Val Leu Pro Ala Phe Asp Ala Leu Gly Gln Leu Thr 
145                 150                 155                 160 


Gly Gly Tyr Lys Pro Asn Pro Gln Ile Tyr Val Lys Leu Ile Glu Glu 
                165                 170                 175     


Cys Thr Asp Leu Gln Lys Glu Gly Glu Phe Ser Thr Cys Phe Thr Glu 
            180                 185                 190         


Leu Gln Arg Asp Phe Leu Lys Gln Arg Pro Thr Lys Leu Lys Ser Leu 
        195                 200                 205             


Ile Arg Leu Val Lys His Trp Tyr Gln Asn Cys Lys Lys Lys Leu Gly 
    210                 215                 220                 


Lys Leu Pro Pro Gln Tyr Ala Leu Glu Leu Leu Thr Val Tyr Ala Trp 
225                 230                 235                 240 


Glu Arg Gly Ser Met Lys Thr His Phe Asn Thr Ala Gln Gly Phe Arg 
                245                 250                 255     


Thr Val Leu Glu Leu Val Ile Asn Tyr Gln Gln Leu Cys Ile Tyr Trp 
            260                 265                 270         


Thr Lys Tyr Tyr Asp Phe Lys Asn Pro Ile Ile Glu Lys Tyr Leu Arg 
        275                 280                 285             


Arg Gln Leu Thr Lys Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro 
    290                 295                 300                 


Thr Gly Asn Leu Gly Gly Gly Asp Pro Lys Gly Trp Arg Gln Leu Ala 
305                 310                 315                 320 


Gln Glu Ala Glu Ala Trp Leu Asn Tyr Pro Cys Phe Lys Asn Trp Asp 
                325                 330                 335     


Gly Ser Pro Val Ser Ser Trp Ile Leu Leu Thr Gln His Thr Pro Gly 
            340                 345                 350         


Ser Ile His Pro Thr Gly Arg Arg Gly Leu Asp Leu His His Pro Leu 
        355                 360                 365             


Asn Ala Ser Ala Ser Trp Gly Lys Gly Leu Gln Cys Tyr Leu Asp Gln 
    370                 375                 380                 


Phe Leu His Phe Gln Val Gly Leu Leu Ile Gln Arg Gly Gln Ser Ser 
385                 390                 395                 400 


Ser Val Ser Trp Cys Ile Ile Gln Asp Arg Thr Gln Val Ser 
                405                 410                 


<210>  19
<211>  3539
<212>  DNA
<213>  Homo sapiens

<400>  19
caagagttgg taagctcgct gcagtgggtg gagagaggcc tctagacttc agtttcagtt       60

tcctggctct gggcagcagc aagaattcct ctgcctccca tcctaccatt cactgtcttg      120

ccggcagcca gctgagagca atgggaaatg gggagtccca gctgtcctcg gtgcctgctc      180

agaagctggg ttggtttatc caggaatacc tgaagcccta cgaagaatgt cagacactga      240

tcgacgagat ggtgaacacc atctgtgacg tcctgcagga acccgaacag ttccccctgg      300

tgcagggagt ggccataggt ggctcctatg gacggaaaac agtcttaaga ggcaactccg      360

atggtaccct tgtcctcttc ttcagtgact taaaacaatt ccaggatcag aagagaagcc      420

aacgtgacat cctcgataaa actggggata agctgaagtt ctgtctgttc acgaagtggt      480

tgaaaaacaa tttcgagatc cagaagtccc ttgatgggtt caccatccag gtgttcacaa      540

aaaatcagag aatctctttc gaggtgctgg ccgccttcaa cgctctgagc ttaaatgata      600

atcccagccc ctggatctat cgagagctca aaagatcctt ggataagaca aatgccagtc      660

ctggtgagtt tgcagtctgc ttcactgaac tccagcagaa gttttttgac aaccgtcctg      720

gaaaactaaa ggatttgatc ctcttgataa agcactggca tcaacagtgc cagaaaaaaa      780

tcaaggattt accctcgctg tctccgtatg ccctggagct gcttacggtg tatgcctggg      840

aacaggggtg cagaaaagac aactttgaca ttgctgaagg cgtcagaacc gtactggagc      900

tgatcaaatg ccaggagaag ctgtgtatct attggatggt caactacaac tttgaagatg      960

agaccatcag gaacatcctg ctgcaccagc tccaatcagc gaggccagta atcttggatc     1020

cagttgaccc aaccaataat gtgagtggag ataaaatatg ctggcaatgg ctgaaaaaag     1080

aagctcaaac ctggttgact tctcccaacc tggataatga gttacctgca ccatcttgga     1140

atgttctgcc tgcaccactc ttcacgaccc caggccacct tctggataag ttcatcaagg     1200

agtttctcca gcccaacaaa tgcttcctag agcagattga cagtgctgtt aacatcatcc     1260

gtacattcct taaagaaaac tgcttccgac aatcaacagc caagatccag attgtccggg     1320

gaggatcaac cgccaaaggc acagctctga agactggctc tgatgccgat ctcgtcgtgt     1380

tccataactc acttaaaagc tacacctccc aaaaaaacga gcggcacaaa atcgtcaagg     1440

aaatccatga acagctgaaa gccttttgga gggagaagga ggaggagctt gaagtcagct     1500

ttgagcctcc caagtggaag gctcccaggg tgctgagctt ctctctgaaa tccaaagtcc     1560

tcaacgaaag tgtcagcttt gatgtgcttc ctgcctttaa tgcactgggt cagctgagtt     1620

ctggctccac acccagcccc gaggtttatg cagggctcat tgatctgtat aaatcctcgg     1680

acctcccggg aggagagttt tctacctgtt tcacagtcct gcagcgaaac ttcattcgct     1740

cccggcccac caaactaaag gatttaattc gcctggtgaa gcactggtac aaagagtgtg     1800

aaaggaaact gaagccaaag gggtctttgc ccccaaagta tgccttggag ctgctcacca     1860

tctatgcctg ggagcagggg agtggagtgc cggattttga cactgcagaa ggtttccgga     1920

cagtcctgga gctggtcaca caatatcagc agctctgcat cttctggaag gtcaattaca     1980

actttgaaga tgagaccgtg aggaagtttc tactgagcca gttgcagaaa accaggcctg     2040

tgatcttgga cccagccgaa cccacaggtg acgtgggtgg aggggaccgt tggtgttggc     2100

atcttctggc aaaagaagca aaggaatggt tatcctctcc ctgcttcaag gatgggactg     2160

gaaacccaat accaccttgg aaagtgccga caatgcagac accaggaagt tgtggagcta     2220

ggatccatcc tattgtcaat gagatgttct catccagaag ccatagaatc ctgaataata     2280

attctaaaag aaacttctag agatcatctg gcaatcgctt ttaaagactc ggctcaccgt     2340

gagaaagagt cactcacatc cattcttccc ttgatggtcc ctattcctcc ttcccttgct     2400

tcttggactt cttgaaatca atcaagactg caaacccttt cataaagtct tgccttgctg     2460

aactccctct ctgcaggcag cctgccttta aaaatagttg ctgtcatcca ctttatgtgc     2520

atcttatttc tgtcaacttg tatttttttt cttgtatttt tccaattagc tcctcctttt     2580

tccttccagt ctaaaaaagg aatcctctgt gtcttcaaag caaagctctt tactttcccc     2640

ttggttctca taactctgtg atcttgctct cggtgcttcc aactcatcca cgtcctgtct     2700

gtttcctctg tatacaaaac cctttctgcc cctgctgaca cagacatcct ctatgccagc     2760

agccagccaa ccctttcatt agaacttcaa gctctccaaa ggctcagatt ataactgttg     2820

tcatatttat atgaggctgt tgtcttttcc ttctgagcct gcctttctcc cccccaccca     2880

ggagtatcct cttgccaaat caaaagactt tttccttggg ctttagcctt aaagatactt     2940

gaaggtctag gtgctttaac ctcacatacc ctcacttaaa cttttatcac tgttgcatat     3000

accagttgtg atacaataaa gaatgtatct ggattttgtg cctagttcct agcacacagc     3060

ttcaaaaatt ctagagtttc ctgataggag tgtcttttgt attcataaca agcccttttc     3120

acccatgcct gggtttatgc taacaaggtt acccatggtg ggcccttagt ttcaaggaag     3180

gagttggcca agccagaaag accaagcatg tggttaaagc attggaattt tcagccccat     3240

cccaccccca atctccaagg aggtgatggg gctggaaatt gagttcaatt ttaacatggc     3300

cagtgattta agcaatgctg cctatgtaaa gaaaccccaa taaaaactct ggacagtgag     3360

gcttggggag cttcctgatt ggcagacatt ccaatgtact aggaaggtag cgcatcttga     3420

ttccacaggg acaaaggctc ctgagctctg ggcccttcca gtgcttgcca ccctacatac     3480

tctttgtctg gctcttcatt tgtattcttt ataataaaat ggtgattgta agtagagca      3539


<210>  20
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Gly Asn Gly Glu Ser Gln Leu Ser Ser Val Pro Ala Gln Lys Leu 
1               5                   10                  15      


Gly Trp Phe Ile Gln Glu Tyr Leu Lys Pro Tyr Glu Glu Cys Gln Thr 
            20                  25                  30          


Leu Ile Asp Glu Met Val Asn Thr Ile Cys Asp Val Leu Gln Glu Pro 
        35                  40                  45              


Glu Gln Phe Pro Leu Val Gln Gly Val Ala Ile Gly Gly Ser Tyr Gly 
    50                  55                  60                  


Arg Lys Thr Val Leu Arg Gly Asn Ser Asp Gly Thr Leu Val Leu Phe 
65                  70                  75                  80  


Phe Ser Asp Leu Lys Gln Phe Gln Asp Gln Lys Arg Ser Gln Arg Asp 
                85                  90                  95      


Ile Leu Asp Lys Thr Gly Asp Lys Leu Lys Phe Cys Leu Phe Thr Lys 
            100                 105                 110         


Trp Leu Lys Asn Asn Phe Glu Ile Gln Lys Ser Leu Asp Gly Phe Thr 
        115                 120                 125             


Ile Gln Val Phe Thr Lys Asn Gln Arg Ile Ser Phe Glu Val Leu Ala 
    130                 135                 140                 


Ala Phe Asn Ala Leu Ser Leu Asn Asp Asn Pro Ser Pro Trp Ile Tyr 
145                 150                 155                 160 


Arg Glu Leu Lys Arg Ser Leu Asp Lys Thr Asn Ala Ser Pro Gly Glu 
                165                 170                 175     


Phe Ala Val Cys Phe Thr Glu Leu Gln Gln Lys Phe Phe Asp Asn Arg 
            180                 185                 190         


Pro Gly Lys Leu Lys Asp Leu Ile Leu Leu Ile Lys His Trp His Gln 
        195                 200                 205             


Gln Cys Gln Lys Lys Ile Lys Asp Leu Pro Ser Leu Ser Pro Tyr Ala 
    210                 215                 220                 


Leu Glu Leu Leu Thr Val Tyr Ala Trp Glu Gln Gly Cys Arg Lys Asp 
225                 230                 235                 240 


Asn Phe Asp Ile Ala Glu Gly Val Arg Thr Val Leu Glu Leu Ile Lys 
                245                 250                 255     


Cys Gln Glu Lys Leu Cys Ile Tyr Trp Met Val Asn Tyr Asn Phe Glu 
            260                 265                 270         


Asp Glu Thr Ile Arg Asn Ile Leu Leu His Gln Leu Gln Ser Ala Arg 
        275                 280                 285             


Pro Val Ile Leu Asp Pro Val Asp Pro Thr Asn Asn Val Ser Gly Asp 
    290                 295                 300                 


Lys Ile Cys Trp Gln Trp Leu Lys Lys Glu Ala Gln Thr Trp Leu Thr 
305                 310                 315                 320 


Ser Pro Asn Leu Asp Asn Glu Leu Pro Ala Pro Ser Trp Asn Val Leu 
                325                 330                 335     


Pro Ala Pro Leu Phe Thr Thr Pro Gly His Leu Leu Asp Lys Phe Ile 
            340                 345                 350         


Lys Glu Phe Leu Gln Pro Asn Lys Cys Phe Leu Glu Gln Ile Asp Ser 
        355                 360                 365             


Ala Val Asn Ile Ile Arg Thr Phe Leu Lys Glu Asn Cys Phe Arg Gln 
    370                 375                 380                 


Ser Thr Ala Lys Ile Gln Ile Val Arg Gly Gly Ser Thr Ala Lys Gly 
385                 390                 395                 400 


Thr Ala Leu Lys Thr Gly Ser Asp Ala Asp Leu Val Val Phe His Asn 
                405                 410                 415     


Ser Leu Lys Ser Tyr Thr Ser Gln Lys Asn Glu Arg His Lys Ile Val 
            420                 425                 430         


Lys Glu Ile His Glu Gln Leu Lys Ala Phe Trp Arg Glu Lys Glu Glu 
        435                 440                 445             


Glu Leu Glu Val Ser Phe Glu Pro Pro Lys Trp Lys Ala Pro Arg Val 
    450                 455                 460                 


Leu Ser Phe Ser Leu Lys Ser Lys Val Leu Asn Glu Ser Val Ser Phe 
465                 470                 475                 480 


Asp Val Leu Pro Ala Phe Asn Ala Leu Gly Gln Leu Ser Ser Gly Ser 
                485                 490                 495     


Thr Pro Ser Pro Glu Val Tyr Ala Gly Leu Ile Asp Leu Tyr Lys Ser 
            500                 505                 510         


Ser Asp Leu Pro Gly Gly Glu Phe Ser Thr Cys Phe Thr Val Leu Gln 
        515                 520                 525             


Arg Asn Phe Ile Arg Ser Arg Pro Thr Lys Leu Lys Asp Leu Ile Arg 
    530                 535                 540                 


Leu Val Lys His Trp Tyr Lys Glu Cys Glu Arg Lys Leu Lys Pro Lys 
545                 550                 555                 560 


Gly Ser Leu Pro Pro Lys Tyr Ala Leu Glu Leu Leu Thr Ile Tyr Ala 
                565                 570                 575     


Trp Glu Gln Gly Ser Gly Val Pro Asp Phe Asp Thr Ala Glu Gly Phe 
            580                 585                 590         


Arg Thr Val Leu Glu Leu Val Thr Gln Tyr Gln Gln Leu Cys Ile Phe 
        595                 600                 605             


Trp Lys Val Asn Tyr Asn Phe Glu Asp Glu Thr Val Arg Lys Phe Leu 
    610                 615                 620                 


Leu Ser Gln Leu Gln Lys Thr Arg Pro Val Ile Leu Asp Pro Ala Glu 
625                 630                 635                 640 


Pro Thr Gly Asp Val Gly Gly Gly Asp Arg Trp Cys Trp His Leu Leu 
                645                 650                 655     


Ala Lys Glu Ala Lys Glu Trp Leu Ser Ser Pro Cys Phe Lys Asp Gly 
            660                 665                 670         


Thr Gly Asn Pro Ile Pro Pro Trp Lys Val Pro Thr Met Gln Thr Pro 
        675                 680                 685             


Gly Ser Cys Gly Ala Arg Ile His Pro Ile Val Asn Glu Met Phe Ser 
    690                 695                 700                 


Ser Arg Ser His Arg Ile Leu Asn Asn Asn Ser Lys Arg Asn Phe 
705                 710                 715                 


<210>  21
<211>  3647
<212>  DNA
<213>  Homo sapiens

<400>  21
caagagttgg taagctcgct gcagtgggtg gagagaggcc tctagacttc agtttcagtt       60

tcctggctct gggcagcagc aagaattcct ctgcctccca tcctaccatt cactgtcttg      120

ccggcagcca gctgagagca atgggaaatg gggagtccca gctgtcctcg gtgcctgctc      180

agaagctggg ttggtttatc caggaatacc tgaagcccta cgaagaatgt cagacactga      240

tcgacgagat ggtgaacacc atctgtgacg tcctgcagga acccgaacag ttccccctgg      300

tgcagggagt ggccataggt ggctcctatg gacggaaaac agtcttaaga ggcaactccg      360

atggtaccct tgtcctcttc ttcagtgact taaaacaatt ccaggatcag aagagaagcc      420

aacgtgacat cctcgataaa actggggata agctgaagtt ctgtctgttc acgaagtggt      480

tgaaaaacaa tttcgagatc cagaagtccc ttgatgggtt caccatccag gtgttcacaa      540

aaaatcagag aatctctttc gaggtgctgg ccgccttcaa cgctctgagc ttaaatgata      600

atcccagccc ctggatctat cgagagctca aaagatcctt ggataagaca aatgccagtc      660

ctggtgagtt tgcagtctgc ttcactgaac tccagcagaa gttttttgac aaccgtcctg      720

gaaaactaaa ggatttgatc ctcttgataa agcactggca tcaacagtgc cagaaaaaaa      780

tcaaggattt accctcgctg tctccgtatg ccctggagct gcttacggtg tatgcctggg      840

aacaggggtg cagaaaagac aactttgaca ttgctgaagg cgtcagaacc gtactggagc      900

tgatcaaatg ccaggagaag ctgtgtatct attggatggt caactacaac tttgaagatg      960

agaccatcag gaacatcctg ctgcaccagc tccaatcagc gaggccagta atcttggatc     1020

cagttgaccc aaccaataat gtgagtggag ataaaatatg ctggcaatgg ctgaaaaaag     1080

aagctcaaac ctggttgact tctcccaacc tggataatga gttacctgca ccatcttgga     1140

atgttctgcc tgcaccactc ttcacgaccc caggccacct tctggataag ttcatcaagg     1200

agtttctcca gcccaacaaa tgcttcctag agcagattga cagtgctgtt aacatcatcc     1260

gtacattcct taaagaaaac tgcttccgac aatcaacagc caagatccag attgtccggg     1320

gaggatcaac cgccaaaggc acagctctga agactggctc tgatgccgat ctcgtcgtgt     1380

tccataactc acttaaaagc tacacctccc aaaaaaacga gcggcacaaa atcgtcaagg     1440

aaatccatga acagctgaaa gccttttgga gggagaagga ggaggagctt gaagtcagct     1500

ttgagcctcc caagtggaag gctcccaggg tgctgagctt ctctctgaaa tccaaagtcc     1560

tcaacgaaag tgtcagcttt gatgtgcttc ctgcctttaa tgcactgggt cagctgagtt     1620

ctggctccac acccagcccc gaggtttatg cagggctcat tgatctgtat aaatcctcgg     1680

acctcccggg aggagagttt tctacctgtt tcacagtcct gcagcgaaac ttcattcgct     1740

cccggcccac caaactaaag gatttaattc gcctggtgaa gcactggtac aaagagtgtg     1800

aaaggaaact gaagccaaag gggtctttgc ccccaaagta tgccttggag ctgctcacca     1860

tctatgcctg ggagcagggg agtggagtgc cggattttga cactgcagaa ggtttccgga     1920

cagtcctgga gctggtcaca caatatcagc agctctgcat cttctggaag gtcaattaca     1980

actttgaaga tgagaccgtg aggaagtttc tactgagcca gttgcagaaa accaggcctg     2040

tgatcttgga cccagccgaa cccacaggtg acgtgggtgg aggggaccgt tggtgttggc     2100

atcttctggc aaaagaagca aaggaatggt tatcctctcc ctgcttcaag gatgggactg     2160

gaaacccaat accaccttgg aaagtgccgg taaaagtcat ctaaaggagg cgttgtctgg     2220

aaatagccct gtaacaggct tgaatcaaag aacttctcct actgtagcaa cctgaaatta     2280

actcagacac aaataaagga aacccagctc acaggagctt aaacagctgg tcagccccct     2340

aagcccccac tacaagtgat cctcaggcag gtaaccccag attcatgcac tgtagggtgc     2400

tgcgcagcat ccctagtctc tacccagtag atgccactag ccctcctctc ccagtgacaa     2460

ccaaaagtct tcagacattg tcaaacgttc ccctgggttc acagatcttt ctgcctttgg     2520

cttttggctc caccctcttt agctgttaat ttgagtactt atggccctga aagcggccac     2580

ggtgcctcca gatggcaggt ttgcaatcca agcaggaaga aggaaaagat acccaaaggt     2640

caagaacaca gtgattttat tagaagtttc atccgcaaat tttcttccat ttcattgctc     2700

agaaatgtca tgtggctacc tgtaacttga aggtggctac aaagatgact gtggacgtgg     2760

gttgcactgg ccacccaagg atgtctgcca cacctctcca aagccctccc tacctaccaa     2820

gatatacctg atatattcca ccaggatatc ctccctccag atatacttgg ttctctccac     2880

caggttcttt ctttaaagca ggatttctca actttgatac ttactcacat ttggggctag     2940

acagttcttt gtttggaggc tctcttgtgc attgtaggat gttgagcagc atctctggcc     3000

tgtacccagt agatgccacc cagttgtgac aattaaaagt gtcttgagac tttatcatgt     3060

gtcttctgcc ctaggtgaga acccttgcac tagaggaacc ctacacccca accctggggg     3120

gaatgtaggg aagaggtggc caagccaacc gtggggttag ctctaattat taagatatgc     3180

attataaata aataccaaaa aattgtctct ggcaatagtt accttcccag atacaggtcc     3240

cccctttttt cccctaactc ttttaagcaa tgattgtaac tattaggaga cattgctctc     3300

ccacgtatgt ttttcttttt agacaatgca gacaccagga agttgtggag ctaggatcca     3360

tcctattgtc aatgagatgt tctcatccag aagccataga atcctgaata ataattctaa     3420

aagaaacttc tagagatcat ctggcaatcg cttttaaaga ctcggctcac cgtgagaaag     3480

agtcactcac atccattctt cccttgatgg tccctattcc tccttccctt gcttcttgga     3540

cttcttgaaa tcaatcaaga ctgcaaaccc tttcataaag tcttgccttg ctgaactccc     3600

tctctgcagg cagcctgcct ttaaaaatag ttgctgtcat ccacttt                   3647


<210>  22
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Gly Asn Gly Glu Ser Gln Leu Ser Ser Val Pro Ala Gln Lys Leu 
1               5                   10                  15      


Gly Trp Phe Ile Gln Glu Tyr Leu Lys Pro Tyr Glu Glu Cys Gln Thr 
            20                  25                  30          


Leu Ile Asp Glu Met Val Asn Thr Ile Cys Asp Val Leu Gln Glu Pro 
        35                  40                  45              


Glu Gln Phe Pro Leu Val Gln Gly Val Ala Ile Gly Gly Ser Tyr Gly 
    50                  55                  60                  


Arg Lys Thr Val Leu Arg Gly Asn Ser Asp Gly Thr Leu Val Leu Phe 
65                  70                  75                  80  


Phe Ser Asp Leu Lys Gln Phe Gln Asp Gln Lys Arg Ser Gln Arg Asp 
                85                  90                  95      


Ile Leu Asp Lys Thr Gly Asp Lys Leu Lys Phe Cys Leu Phe Thr Lys 
            100                 105                 110         


Trp Leu Lys Asn Asn Phe Glu Ile Gln Lys Ser Leu Asp Gly Phe Thr 
        115                 120                 125             


Ile Gln Val Phe Thr Lys Asn Gln Arg Ile Ser Phe Glu Val Leu Ala 
    130                 135                 140                 


Ala Phe Asn Ala Leu Ser Leu Asn Asp Asn Pro Ser Pro Trp Ile Tyr 
145                 150                 155                 160 


Arg Glu Leu Lys Arg Ser Leu Asp Lys Thr Asn Ala Ser Pro Gly Glu 
                165                 170                 175     


Phe Ala Val Cys Phe Thr Glu Leu Gln Gln Lys Phe Phe Asp Asn Arg 
            180                 185                 190         


Pro Gly Lys Leu Lys Asp Leu Ile Leu Leu Ile Lys His Trp His Gln 
        195                 200                 205             


Gln Cys Gln Lys Lys Ile Lys Asp Leu Pro Ser Leu Ser Pro Tyr Ala 
    210                 215                 220                 


Leu Glu Leu Leu Thr Val Tyr Ala Trp Glu Gln Gly Cys Arg Lys Asp 
225                 230                 235                 240 


Asn Phe Asp Ile Ala Glu Gly Val Arg Thr Val Leu Glu Leu Ile Lys 
                245                 250                 255     


Cys Gln Glu Lys Leu Cys Ile Tyr Trp Met Val Asn Tyr Asn Phe Glu 
            260                 265                 270         


Asp Glu Thr Ile Arg Asn Ile Leu Leu His Gln Leu Gln Ser Ala Arg 
        275                 280                 285             


Pro Val Ile Leu Asp Pro Val Asp Pro Thr Asn Asn Val Ser Gly Asp 
    290                 295                 300                 


Lys Ile Cys Trp Gln Trp Leu Lys Lys Glu Ala Gln Thr Trp Leu Thr 
305                 310                 315                 320 


Ser Pro Asn Leu Asp Asn Glu Leu Pro Ala Pro Ser Trp Asn Val Leu 
                325                 330                 335     


Pro Ala Pro Leu Phe Thr Thr Pro Gly His Leu Leu Asp Lys Phe Ile 
            340                 345                 350         


Lys Glu Phe Leu Gln Pro Asn Lys Cys Phe Leu Glu Gln Ile Asp Ser 
        355                 360                 365             


Ala Val Asn Ile Ile Arg Thr Phe Leu Lys Glu Asn Cys Phe Arg Gln 
    370                 375                 380                 


Ser Thr Ala Lys Ile Gln Ile Val Arg Gly Gly Ser Thr Ala Lys Gly 
385                 390                 395                 400 


Thr Ala Leu Lys Thr Gly Ser Asp Ala Asp Leu Val Val Phe His Asn 
                405                 410                 415     


Ser Leu Lys Ser Tyr Thr Ser Gln Lys Asn Glu Arg His Lys Ile Val 
            420                 425                 430         


Lys Glu Ile His Glu Gln Leu Lys Ala Phe Trp Arg Glu Lys Glu Glu 
        435                 440                 445             


Glu Leu Glu Val Ser Phe Glu Pro Pro Lys Trp Lys Ala Pro Arg Val 
    450                 455                 460                 


Leu Ser Phe Ser Leu Lys Ser Lys Val Leu Asn Glu Ser Val Ser Phe 
465                 470                 475                 480 


Asp Val Leu Pro Ala Phe Asn Ala Leu Gly Gln Leu Ser Ser Gly Ser 
                485                 490                 495     


Thr Pro Ser Pro Glu Val Tyr Ala Gly Leu Ile Asp Leu Tyr Lys Ser 
            500                 505                 510         


Ser Asp Leu Pro Gly Gly Glu Phe Ser Thr Cys Phe Thr Val Leu Gln 
        515                 520                 525             


Arg Asn Phe Ile Arg Ser Arg Pro Thr Lys Leu Lys Asp Leu Ile Arg 
    530                 535                 540                 


Leu Val Lys His Trp Tyr Lys Glu Cys Glu Arg Lys Leu Lys Pro Lys 
545                 550                 555                 560 


Gly Ser Leu Pro Pro Lys Tyr Ala Leu Glu Leu Leu Thr Ile Tyr Ala 
                565                 570                 575     


Trp Glu Gln Gly Ser Gly Val Pro Asp Phe Asp Thr Ala Glu Gly Phe 
            580                 585                 590         


Arg Thr Val Leu Glu Leu Val Thr Gln Tyr Gln Gln Leu Cys Ile Phe 
        595                 600                 605             


Trp Lys Val Asn Tyr Asn Phe Glu Asp Glu Thr Val Arg Lys Phe Leu 
    610                 615                 620                 


Leu Ser Gln Leu Gln Lys Thr Arg Pro Val Ile Leu Asp Pro Ala Glu 
625                 630                 635                 640 


Pro Thr Gly Asp Val Gly Gly Gly Asp Arg Trp Cys Trp His Leu Leu 
                645                 650                 655     


Ala Lys Glu Ala Lys Glu Trp Leu Ser Ser Pro Cys Phe Lys Asp Gly 
            660                 665                 670         


Thr Gly Asn Pro Ile Pro Pro Trp Lys Val Pro Val Lys Val Ile 
        675                 680                 685         


<210>  23
<211>  2123
<212>  DNA
<213>  Homo sapiens

<400>  23
caagagttgg taagctcgct gcagtgggtg gagagaggcc tctagacttc agtttcagtt       60

tcctggctct gggcagcagc aagaattcct ctgcctccca tcctaccatt cactgtcttg      120

ccggcagcca gctgagagca atgggaaatg gggagtccca gctgtcctcg gtgcctgctc      180

agaagctggg ttggtttatc caggaatacc tgaagcccta cgaagaatgt cagacactga      240

tcgacgagat ggtgaacacc atctgtgacg tcctgcagga acccgaacag ttccccctgg      300

tgcagggagt ggccataggt ggctcctatg gacggaaaac agtcttaaga ggcaactccg      360

atggtaccct tgtcctcttc ttcagtgact taaaacaatt ccaggatcag aagagaagcc      420

aacgtgacat cctcgataaa actggggata agctgaagtt ctgtctgttc acgaagtggt      480

tgaaaaacaa tttcgagatc cagaagtccc ttgatgggtt caccatccag gtgttcacaa      540

aaaatcagag aatctctttc gaggtgctgg ccgccttcaa cgctctgagt aagcattgct      600

gggtgtcagg agagaaaagc caaagaagcg ggtgccagac agctctgtgc aacctctagg      660

ccatgagtgg gatagatacc actgctgctt taaaaaatgg gagaccatag accctcagga      720

gagaagaatc ccttctaccc tggactcgct ctcttctctg gaactaactt ctcccccata      780

ccctgattgt ctttggagaa aatgttctgg attctagaat ctaaggcaga gccttttaag      840

ccatactgta cacataaatc acctggaacc ttgttaaaat gcagatcctg actcaggagg      900

tctgagttag agcccaggat ttcatatttc tagccagctc catgatgagc tgctggtccg      960

cagatcatgc ttgcaggttt tgaccagagt cagtgttggt tagagtaaga ggatgaggca     1020

gacatctggg aaaagtccag ctggggcaag catttgaagt ctgccttcct accaggtcaa     1080

aatcaaggca acgaccttcc atagataact atcaaagctt gagggggtgc cttgaaccca     1140

actcctaaat ccctaagacc tgcccacctc ttgtgtctcc tgtctcagca aacattccca     1200

cactcttgca tattgttaaa gtaacctctg cttaccaggc ttctggttta ataaaagatg     1260

gctagagtga ctccatctta aagcaagtag ctaggcactc aaaaggaacc tacaggctta     1320

atacttgggt ctgaaaatag ccacagtcta agctgaccac caattataat tgcagaatat     1380

ttaaggccat acaaaacatc tcccactaag cctacaaaat gtccaggtgt cctaaaagtt     1440

cagcccactt aaaggcagca ttaatgagca ggtttaggtt gaaggattaa tggtcatcaa     1500

taccactgtt aagaagaaaa ttcttggcca aattgaattt aatggagttt aactgagcag     1560

acaattcaca aatctagaag cctcctgagc cagagtaggt tcagagagtc ttgaacacag     1620

ccacgtggtg gaagaagatt tatggacagg aaaaggaaaa tgatgtactg aaaatgaaag     1680

tgaggtacag aaacagccag actggttata gctcagcatt ggccttattt gaacgagatt     1740

tgaacagttg gccacctttg attggccgaa actcagtgat tggcacaaga gtaggttgca     1800

gtctgtttac acatcctttt aggttatagt tcaccatgta cagagaaatt ttaggccaaa     1860

cttaaaatat gtaaggaggc agctttaggc taaacttgat ttaacagcac caataccccc     1920

tacctttagt gagcacatct gcacattcca attttaatga cagctcctta gaatttctta     1980

tcaacgaaga cactaacaaa gaatggcgca ttcctccttc tcctttctga ggatgcccta     2040

ccctgtaaca aagtcgtttc taataaattt gcttctttca ccataaaaaa aaaaaaaaaa     2100

aaaaaaaaaa aaaaaaaaaa aaa                                             2123


<210>  24
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Asn Gly Glu Ser Gln Leu Ser Ser Val Pro Ala Gln Lys Leu 
1               5                   10                  15      


Gly Trp Phe Ile Gln Glu Tyr Leu Lys Pro Tyr Glu Glu Cys Gln Thr 
            20                  25                  30          


Leu Ile Asp Glu Met Val Asn Thr Ile Cys Asp Val Leu Gln Glu Pro 
        35                  40                  45              


Glu Gln Phe Pro Leu Val Gln Gly Val Ala Ile Gly Gly Ser Tyr Gly 
    50                  55                  60                  


Arg Lys Thr Val Leu Arg Gly Asn Ser Asp Gly Thr Leu Val Leu Phe 
65                  70                  75                  80  


Phe Ser Asp Leu Lys Gln Phe Gln Asp Gln Lys Arg Ser Gln Arg Asp 
                85                  90                  95      


Ile Leu Asp Lys Thr Gly Asp Lys Leu Lys Phe Cys Leu Phe Thr Lys 
            100                 105                 110         


Trp Leu Lys Asn Asn Phe Glu Ile Gln Lys Ser Leu Asp Gly Phe Thr 
        115                 120                 125             


Ile Gln Val Phe Thr Lys Asn Gln Arg Ile Ser Phe Glu Val Leu Ala 
    130                 135                 140                 


Ala Phe Asn Ala Leu Ser Lys His Cys Trp Val Ser Gly Glu Lys Ser 
145                 150                 155                 160 


Gln Arg Ser Gly Cys Gln Thr Ala Leu Cys Asn Leu 
                165                 170         


<210>  25
<211>  6646
<212>  DNA
<213>  Homo sapiens

<400>  25
gttcggagag ccgggcggga aaacgaaacc agaaatccga aggccgcgcc agagccctgc       60

ttccccttgc acctgcgccg ggcggccatg gacttgtaca gcaccccggc cgctgcgctg      120

gacaggttcg tggccagaag gctgcagccg cggaaggagt tcgtagagaa ggcgcggcgc      180

gctctgggcg ccctggccgc tgccctgagg gagcgcgggg gccgcctcgg tgctgctgcc      240

ccgcgggtgc tgaaaactgt caagggaggc tcctcgggcc ggggcacagc tctcaagggt      300

ggctgtgatt ctgaacttgt catcttcctc gactgcttca agagctatgt ggaccagagg      360

gcccgccgtg cagagatcct cagtgagatg cgggcatcgc tggaatcctg gtggcagaac      420

ccagtccctg gtctgagact cacgtttcct gagcagagcg tgcctggggc cctgcagttc      480

cgcctgacat ccgtagatct tgaggactgg atggatgtta gcctggtgcc tgccttcaat      540

gtcctgggtc aggccggctc cggcgtcaaa cccaagccac aagtctactc taccctcctc      600

aacagtggct gccaaggggg cgagcatgcg gcctgcttca cagagctgcg gaggaacttt      660

gtgaacattc gcccagccaa gttgaagaac ctaatcttgc tggtgaagca ctggtaccac      720

caggtgtgcc tacaggggtt gtggaaggag acgctgcccc cggtctatgc cctggaattg      780

ctgaccatct tcgcctggga gcagggctgt aagaaggatg ctttcagcct agccgaaggc      840

ctccgaactg tcctgggcct gatccaacag catcagcacc tgtgtgtttt ctggactgtc      900

aactatggct tcgaggaccc tgcagttggg cagttcttgc agcggcagct taagagaccc      960

aggcctgtga tcctggaccc agctgacccc acatgggacc tggggaatgg ggcagcctgg     1020

cactgggatt tgctagccca ggaggcagca tcctgctatg accacccatg ctttctgagg     1080

gggatggggg acccagtgca gtcttggaag gggccgggcc ttccacgtgc tggatgctca     1140

ggtttgggcc accccatcca gctagaccct aaccagaaga cccctgaaaa cagcaagagc     1200

ctcaatgctg tgtacccaag agcagggagc aaacctccct catgcccagc tcctggcccc     1260

actggggcag ccagcatcgt cccctctgtg ccgggaatgg ccttggacct gtctcagatc     1320

cccaccaagg agctggaccg cttcatccag gaccacctga agccgagccc ccagttccag     1380

gagcaggtga aaaaggccat cgacatcatc ttgcgctgcc tccatgagaa ctgtgttcac     1440

aaggcctcaa gagtcagtaa agggggctca tttggccggg gcacagacct aagggatggc     1500

tgtgatgttg aactcatcat cttcctcaac tgcttcacgg actacaagga ccaggggccc     1560

cgccgcgcag agatccttga tgagatgcga gcgcagctag aatcctggtg gcaggaccag     1620

gtgcccagcc tgagccttca gtttcctgag cagaatgtgc ctgaggctct gcagttccag     1680

ctggtgtcca cagccctgaa gagctggacg gatgttagcc tgctgcctgc cttcgatgct     1740

gtggggcagc tcagttctgg caccaaacca aatccccagg tctactcgag gctcctcacc     1800

agtggctgcc aggagggcga gcataaggcc tgcttcgcag agctgcggag gaacttcatg     1860

aacattcgcc ctgtcaagct gaagaacctg attctgctgg tgaagcactg gtaccgccag     1920

gttgcggctc agaacaaagg aaaaggacca gcccctgcct ctctgccccc agcctatgcc     1980

ctggagctcc tcaccatctt tgcctgggag cagggctgca ggcaggattg tttcaacatg     2040

gcccaaggct tccggacggt gctggggctc gtgcaacagc atcagcagct ctgtgtctac     2100

tggacggtca actatagcac tgaggaccca gccatgagaa tgcaccttct tggccagctt     2160

cgaaaaccca gacccctggt cctggacccc gctgatccca cctggaacgt gggccacggt     2220

agctgggagc tgttggccca ggaagcagca gcgctgggga tgcaggcctg ctttctgagt     2280

agagacggga catctgtgca gccctgggat gtgatgccag ccctccttta ccaaacccca     2340

gctggggacc ttgacaagtt catcagtgaa tttctccagc ccaaccgcca gttcctggcc     2400

caggtgaaca aggccgttga taccatctgt tcatttttga aggaaaactg cttccggaat     2460

tctcccatca aagtgatcaa ggtggtcaag ggtggctctt cagccaaagg cacagctctg     2520

cgaggccgct cagatgccga cctcgtggtg ttcctcagct gcttcagcca gttcactgag     2580

cagggcaaca agcgggccga gatcatctcc gagatccgag cccagctgga ggcatgtcaa     2640

caggagcggc agttcgaggt caagtttgaa gtctccaaat gggagaatcc ccgcgtgctg     2700

agcttctcac tgacatccca gacgatgctg gaccagagtg tggactttga tgtgctgcca     2760

gcctttgacg ccctaggcca gctggtctct ggctccaggc ccagctctca agtctacgtc     2820

gacctcatcc acagctacag caatgcgggc gagtactcca cctgcttcac agagctacaa     2880

cgggacttca tcatctctcg ccctaccaag ctgaagagcc tgatccggct ggtgaagcac     2940

tggtaccagc agtgtaccaa gatctccaag gggagaggct ccctaccccc acagcacggg     3000

ctggaactcc tgactgtgta tgcctgggag cagggcggga aggactccca gttcaacatg     3060

gctgagggct tccgcacggt cctggagctg gtcacccagt accgccagct ctgtatctac     3120

tggaccatca actacaacgc caaggacaag actgttggag acttcctgaa acagcagctt     3180

cagaagccca ggcctatcat cctggatccg gctgacccga caggcaacct gggccacaat     3240

gcccgctggg acctgctggc caaggaagct gcagcctgca catctgccct gtgctgcatg     3300

ggacggaatg gcatccccat ccagccatgg ccagtgaagg ctgctgtgtg aagttgagaa     3360

aatcagcggt cctactggat gaagagaaga tggacaccag ccctcagcat gaggaaattc     3420

agggtcccct accagatgag agagattgtg tacatgtgtg tgtgagcaca tgtgtgcatg     3480

tgtgtgcaca cgtgtgcatg tgtgtgtttt agtgaatctg ctctcccagc tcacacactc     3540

ccctgcctcc catggcttac acactaggat ccagactcca tggtttgaca ccagcctgcg     3600

tttgcagctt ctctgtcact tccatgactc tatcctcata ccaccactgc tgcttcccac     3660

ccagctgaga atgccccctc ctccctgact cctctctgcc catgcaaatt agctcacatc     3720

tttcctcctg ctgcaatcca tcccttcctc ccattggcct ctccttgcca aatctaaata     3780

gtttatatag ggatggcaga gagttcccat ctcatctgtc agccacagtc atttggtact     3840

ggctacctgg agccttatct tctgaagggt tttaaagaat ggccaattag ctgagaagaa     3900

ttatctaatc aattagtgat gtctgccatg gatgcagtag aggaaagtgg tggtacaagt     3960

gccatgattg attagcaatg tctgcactgg atacggaaaa aagaaggtgc ttgcaggttt     4020

acagtgtata tgtgggctat tgaagagccc tctgagctcg gttgctagca ggagagcatg     4080

cccatattgg cttactttgt ctgccacaga cacagacaga gggagttggg acatgcatgc     4140

tatggggacc ctcttgttgg acacctaatt ggatgcctct tcatgagagg cctccttttc     4200

ttcacctttt atgctgcact cctcccctag tttacacatc ttgatgctgt ggctcagttt     4260

gccttcctga atttttattg ggtccctgtt ttctctccta acatgctgag attctgcatc     4320

cccacagcct aaactgagcc agtggccaaa caaccgtgct cagcctgttt ctctctgccc     4380

tctagagcaa ggcccaccag gtccatccag gaggctctcc tgacctcaag tccaacaaca     4440

gtgtccacac tagtcaaggt tcagcccaga aaacagaaag cactctagga atcttaggca     4500

gaaagggatt ttatctaaat cactggaaag gctggaggag cagaaggcag aggccaccac     4560

tggactattg gtttcaatat tagaccactg tagccgaatc agaggccaga gagcagccac     4620

tgctactgct aatgccacca ctacccctgc catcactgcc ccacatggac aaaactggag     4680

tcgagaccta ggttagattc ctgcaaccac aaacatccat cagggatggc cagctgccag     4740

agctgcggga agacggatcc cacctccctt tcttagcaga atctaaatta cagccagacc     4800

tctggctgca gaggagtctg agacatgtat gattgaatgg gtgccaagtg ccagggggcg     4860

gagtccccag cagatgcatc ctggccatct gttgcgtgga tgagggagtg ggtctatctc     4920

agaggaagga acaggaaaca aagaaaggaa gccactgaac atcccttctc tgctccacag     4980

gagtgcctta gacagcctga ctctccacaa accactgtta aaacttacct gctaggaatg     5040

ctagattgaa tgggatggga agagccttcc ctcattattg tcattcttgg agagaggtga     5100

gcaaccaagg gaagctcctc tgattcacct agaacctgtt ctctgccgtc tttggctcag     5160

cctacagaga ctagagtagg tgaagggaca gaggacaggg cttctaatac ctgtgccata     5220

ttgacagcct ccatccctgt cccccatctt ggtgctgaac caacgctaag ggcaccttct     5280

tagactcacc tcatcgatac tgcctggtaa tccaaagcta gaactctcag gaccccaaac     5340

tccacctctt ggattggccc tggctgctgc cacacacata tccaagagct cagggccagt     5400

tctggtgggc agcagagacc tgctctgcca agttgtccag cagcagagtg gccctggcct     5460

gggcatcaca agccagtgat gctcctggga agaccaggtg gcaggtcgca gttgggtacc     5520

ttccattccc accacacaga ctctgggcct ccccgcaaaa tggctccaga attagagtaa     5580

ttatgagatg gtgggaacca gagcaactca ggtgcatgat acaaggagag gttgtcatct     5640

gggtagggca gagaggaggg cttgctcatc tgaacagggg tgtatttcat tccaggccct     5700

cagtctttgg caatggccac cctggtgttg gcatattggc cccactgtaa cttttggggg     5760

cttcccggtc tagccacacc ctcggatgga aagacttgac tgcataaaga tgtcagttct     5820

ccctgagttg attgataggc ttaatggtca ccctaaaaac acccacatat gcttttcgat     5880

ggaaccaggt aagttgacgc taaagttctt atggaaaaat acacacgcaa tagctaggaa     5940

aacacaggga aagaagagtt ctgagcaggg cctagtctta gccaatatta aaacatacta     6000

tgaagcctct gatacttaaa cagcatggcg ctggtacgta aatagaccaa tgcagttagg     6060

tggctctttc caagactctg gggaaaaaag tagtaaaaag ctaaatgcaa tcaatcagca     6120

attgaaagct aagtgagaga gccagagggc ctccttggtg gtaaaagagg gttgcatttc     6180

ttgcagccag aaggcagaga aagtgaagac caagtccaga actgaatcct aagaaatgca     6240

ggactgcaaa gaaattggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tttaattttt     6300

aaaaagtttt tattgagata caagtcaata ccataaagct ctcacccttc taaagtgtac     6360

aattcagtgg tgtgagtata ttcataagat ttatacttgg tgtctattca taagacttat     6420

atccagcata ttcataacta gagccatatc acagatgcat tcatcataat aattccagac     6480

attttcatca ccctaaaagg aaaccctgaa acccattagc agtcattccc cattcctcca     6540

acccattctc tccctaatcc ctagaaacca ccaatctgct gtgtatttca tctattgcca     6600

acatttcata taaatggcat catacaaaaa aaaaaaaaaa aaaaaa                    6646


<210>  26
<211>  1087
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Asp Leu Tyr Ser Thr Pro Ala Ala Ala Leu Asp Arg Phe Val Ala 
1               5                   10                  15      


Arg Arg Leu Gln Pro Arg Lys Glu Phe Val Glu Lys Ala Arg Arg Ala 
            20                  25                  30          


Leu Gly Ala Leu Ala Ala Ala Leu Arg Glu Arg Gly Gly Arg Leu Gly 
        35                  40                  45              


Ala Ala Ala Pro Arg Val Leu Lys Thr Val Lys Gly Gly Ser Ser Gly 
    50                  55                  60                  


Arg Gly Thr Ala Leu Lys Gly Gly Cys Asp Ser Glu Leu Val Ile Phe 
65                  70                  75                  80  


Leu Asp Cys Phe Lys Ser Tyr Val Asp Gln Arg Ala Arg Arg Ala Glu 
                85                  90                  95      


Ile Leu Ser Glu Met Arg Ala Ser Leu Glu Ser Trp Trp Gln Asn Pro 
            100                 105                 110         


Val Pro Gly Leu Arg Leu Thr Phe Pro Glu Gln Ser Val Pro Gly Ala 
        115                 120                 125             


Leu Gln Phe Arg Leu Thr Ser Val Asp Leu Glu Asp Trp Met Asp Val 
    130                 135                 140                 


Ser Leu Val Pro Ala Phe Asn Val Leu Gly Gln Ala Gly Ser Gly Val 
145                 150                 155                 160 


Lys Pro Lys Pro Gln Val Tyr Ser Thr Leu Leu Asn Ser Gly Cys Gln 
                165                 170                 175     


Gly Gly Glu His Ala Ala Cys Phe Thr Glu Leu Arg Arg Asn Phe Val 
            180                 185                 190         


Asn Ile Arg Pro Ala Lys Leu Lys Asn Leu Ile Leu Leu Val Lys His 
        195                 200                 205             


Trp Tyr His Gln Val Cys Leu Gln Gly Leu Trp Lys Glu Thr Leu Pro 
    210                 215                 220                 


Pro Val Tyr Ala Leu Glu Leu Leu Thr Ile Phe Ala Trp Glu Gln Gly 
225                 230                 235                 240 


Cys Lys Lys Asp Ala Phe Ser Leu Ala Glu Gly Leu Arg Thr Val Leu 
                245                 250                 255     


Gly Leu Ile Gln Gln His Gln His Leu Cys Val Phe Trp Thr Val Asn 
            260                 265                 270         


Tyr Gly Phe Glu Asp Pro Ala Val Gly Gln Phe Leu Gln Arg Gln Leu 
        275                 280                 285             


Lys Arg Pro Arg Pro Val Ile Leu Asp Pro Ala Asp Pro Thr Trp Asp 
    290                 295                 300                 


Leu Gly Asn Gly Ala Ala Trp His Trp Asp Leu Leu Ala Gln Glu Ala 
305                 310                 315                 320 


Ala Ser Cys Tyr Asp His Pro Cys Phe Leu Arg Gly Met Gly Asp Pro 
                325                 330                 335     


Val Gln Ser Trp Lys Gly Pro Gly Leu Pro Arg Ala Gly Cys Ser Gly 
            340                 345                 350         


Leu Gly His Pro Ile Gln Leu Asp Pro Asn Gln Lys Thr Pro Glu Asn 
        355                 360                 365             


Ser Lys Ser Leu Asn Ala Val Tyr Pro Arg Ala Gly Ser Lys Pro Pro 
    370                 375                 380                 


Ser Cys Pro Ala Pro Gly Pro Thr Gly Ala Ala Ser Ile Val Pro Ser 
385                 390                 395                 400 


Val Pro Gly Met Ala Leu Asp Leu Ser Gln Ile Pro Thr Lys Glu Leu 
                405                 410                 415     


Asp Arg Phe Ile Gln Asp His Leu Lys Pro Ser Pro Gln Phe Gln Glu 
            420                 425                 430         


Gln Val Lys Lys Ala Ile Asp Ile Ile Leu Arg Cys Leu His Glu Asn 
        435                 440                 445             


Cys Val His Lys Ala Ser Arg Val Ser Lys Gly Gly Ser Phe Gly Arg 
    450                 455                 460                 


Gly Thr Asp Leu Arg Asp Gly Cys Asp Val Glu Leu Ile Ile Phe Leu 
465                 470                 475                 480 


Asn Cys Phe Thr Asp Tyr Lys Asp Gln Gly Pro Arg Arg Ala Glu Ile 
                485                 490                 495     


Leu Asp Glu Met Arg Ala Gln Leu Glu Ser Trp Trp Gln Asp Gln Val 
            500                 505                 510         


Pro Ser Leu Ser Leu Gln Phe Pro Glu Gln Asn Val Pro Glu Ala Leu 
        515                 520                 525             


Gln Phe Gln Leu Val Ser Thr Ala Leu Lys Ser Trp Thr Asp Val Ser 
    530                 535                 540                 


Leu Leu Pro Ala Phe Asp Ala Val Gly Gln Leu Ser Ser Gly Thr Lys 
545                 550                 555                 560 


Pro Asn Pro Gln Val Tyr Ser Arg Leu Leu Thr Ser Gly Cys Gln Glu 
                565                 570                 575     


Gly Glu His Lys Ala Cys Phe Ala Glu Leu Arg Arg Asn Phe Met Asn 
            580                 585                 590         


Ile Arg Pro Val Lys Leu Lys Asn Leu Ile Leu Leu Val Lys His Trp 
        595                 600                 605             


Tyr Arg Gln Val Ala Ala Gln Asn Lys Gly Lys Gly Pro Ala Pro Ala 
    610                 615                 620                 


Ser Leu Pro Pro Ala Tyr Ala Leu Glu Leu Leu Thr Ile Phe Ala Trp 
625                 630                 635                 640 


Glu Gln Gly Cys Arg Gln Asp Cys Phe Asn Met Ala Gln Gly Phe Arg 
                645                 650                 655     


Thr Val Leu Gly Leu Val Gln Gln His Gln Gln Leu Cys Val Tyr Trp 
            660                 665                 670         


Thr Val Asn Tyr Ser Thr Glu Asp Pro Ala Met Arg Met His Leu Leu 
        675                 680                 685             


Gly Gln Leu Arg Lys Pro Arg Pro Leu Val Leu Asp Pro Ala Asp Pro 
    690                 695                 700                 


Thr Trp Asn Val Gly His Gly Ser Trp Glu Leu Leu Ala Gln Glu Ala 
705                 710                 715                 720 


Ala Ala Leu Gly Met Gln Ala Cys Phe Leu Ser Arg Asp Gly Thr Ser 
                725                 730                 735     


Val Gln Pro Trp Asp Val Met Pro Ala Leu Leu Tyr Gln Thr Pro Ala 
            740                 745                 750         


Gly Asp Leu Asp Lys Phe Ile Ser Glu Phe Leu Gln Pro Asn Arg Gln 
        755                 760                 765             


Phe Leu Ala Gln Val Asn Lys Ala Val Asp Thr Ile Cys Ser Phe Leu 
    770                 775                 780                 


Lys Glu Asn Cys Phe Arg Asn Ser Pro Ile Lys Val Ile Lys Val Val 
785                 790                 795                 800 


Lys Gly Gly Ser Ser Ala Lys Gly Thr Ala Leu Arg Gly Arg Ser Asp 
                805                 810                 815     


Ala Asp Leu Val Val Phe Leu Ser Cys Phe Ser Gln Phe Thr Glu Gln 
            820                 825                 830         


Gly Asn Lys Arg Ala Glu Ile Ile Ser Glu Ile Arg Ala Gln Leu Glu 
        835                 840                 845             


Ala Cys Gln Gln Glu Arg Gln Phe Glu Val Lys Phe Glu Val Ser Lys 
    850                 855                 860                 


Trp Glu Asn Pro Arg Val Leu Ser Phe Ser Leu Thr Ser Gln Thr Met 
865                 870                 875                 880 


Leu Asp Gln Ser Val Asp Phe Asp Val Leu Pro Ala Phe Asp Ala Leu 
                885                 890                 895     


Gly Gln Leu Val Ser Gly Ser Arg Pro Ser Ser Gln Val Tyr Val Asp 
            900                 905                 910         


Leu Ile His Ser Tyr Ser Asn Ala Gly Glu Tyr Ser Thr Cys Phe Thr 
        915                 920                 925             


Glu Leu Gln Arg Asp Phe Ile Ile Ser Arg Pro Thr Lys Leu Lys Ser 
    930                 935                 940                 


Leu Ile Arg Leu Val Lys His Trp Tyr Gln Gln Cys Thr Lys Ile Ser 
945                 950                 955                 960 


Lys Gly Arg Gly Ser Leu Pro Pro Gln His Gly Leu Glu Leu Leu Thr 
                965                 970                 975     


Val Tyr Ala Trp Glu Gln Gly Gly Lys Asp Ser Gln Phe Asn Met Ala 
            980                 985                 990         


Glu Gly Phe Arg Thr Val Leu Glu  Leu Val Thr Gln Tyr  Arg Gln Leu 
        995                 1000                 1005             


Cys Ile  Tyr Trp Thr Ile Asn  Tyr Asn Ala Lys Asp  Lys Thr Val 
    1010                 1015                 1020             


Gly Asp  Phe Leu Lys Gln Gln  Leu Gln Lys Pro Arg  Pro Ile Ile 
    1025                 1030                 1035             


Leu Asp  Pro Ala Asp Pro Thr  Gly Asn Leu Gly His  Asn Ala Arg 
    1040                 1045                 1050             


Trp Asp  Leu Leu Ala Lys Glu  Ala Ala Ala Cys Thr  Ser Ala Leu 
    1055                 1060                 1065             


Cys Cys  Met Gly Arg Asn Gly  Ile Pro Ile Gln Pro  Trp Pro Val 
    1070                 1075                 1080             


Lys Ala  Ala Val 
    1085         


<210>  27
<211>  2103
<212>  DNA
<213>  Homo sapiens

<400>  27
tgactagacg gccagcctgt taaggtggcc ccagatattc cagcctcagc ccagagtcct       60

cctgtgcccc tactgcagca agggtgtctc caagaagggg gacctggagt cagcccgtca      120

cacctggttt cctctctgct agggtccctc ctcccacaga gcactggagg gcagctgagg      180

aggagctacc ttaaaaaagg aggtgtgtgc cagggagctg ggtaggagcc tggctatata      240

tctgcccagc agcggtactc tcgggacaga gatggcactg atgcaggaac tgtatagcac      300

accagcctcc aggctggact ccttcgtggc tcagtggctg cagccccacc gggagtggaa      360

ggaagaggtg ctagacgctg tgcggaccgt ggaggagttt ctgaggcagg agcatttcca      420

ggggaagcgt gggctggacc aggatgtgcg ggtgctgaag gtagtcaagg tgggctcctt      480

cgggaatggc acggttctca ggagcaccag agaggtggag ctggtggcgt ttctgagctg      540

tttccacagc ttccaggagg cagccaagca tcacaaagat gttctgaggc tgatatggaa      600

aaccatgtgg caaagccagg acctgctgga cctcgggctc gaggacctga ggatggagca      660

gagagtcccc gatgctctcg tcttcaccat ccagaccagg gggactgcgg agcccatcac      720

ggtcaccatt gtgcctgcct acagagccct ggggccttct cttcccaact cccagccacc      780

ccctgaggtc tatgtgagcc tgatcaaggc ctgcggtggt cctggaaatt tctgcccatc      840

cttcagcgag ctgcagagaa atttcgtgaa acatcggcca actaagctga agagcctcct      900

gcgcctggtg aaacactggt accagcagta tgtgaaagcc aggtccccca gagccaatct      960

gccccctctc tatgctcttg aacttctaac catctatgcc tgggaaatgg gtactgaaga     1020

agacgagaat ttcatgttgg acgaaggctt caccactgtg atggacctgc tcctggagta     1080

tgaagtcatc tgtatctact ggaccaagta ctacacactc cacaatgcaa tcattgagga     1140

ttgtgtcaga aaacagctca aaaaagagag gcccatcatc ctggatccgg ccgaccccac     1200

cctcaacgtg gcagaagggt acagatggga catcgttgct cagagggcct cccagtgcct     1260

gaaacaggac tgttgctatg acaacaggga gaaccccatc tccagctgga acgtgaagag     1320

ggcacgagac atccacttga cagtggagca gaggggttac ccagatttca acctcatcgt     1380

gaacccttat gagcccataa ggaaggttaa agagaaaatc cggaggacca ggggctactc     1440

tggcctgcag cgtctgtcct tccaggttcc tggcagtgag aggcagcttc tcagcagcag     1500

gtgctcctta gccaaatatg ggatcttctc ccacactcac atctatctgc tggagaccat     1560

cccctccgag atccaggtct tcgtgaagaa tcctgatggt gggagctacg cctatgccat     1620

caaccccaac agcttcatcc tgggtctgaa gcagcagatt gaagaccagc aggggcttcc     1680

taaaaagcag cagcagctgg aattccaagg ccaagtcctg caggactggt tgggtctggg     1740

gatctatggc atccaagaca gtgacactct catcctctcg aagaagaaag gagaggctct     1800

gtttccagcc agttagtttt ctctgggaga cttctctgta catttctgcc atgtactcca     1860

gaactcatcc tgtcaatcac tctgtcccat tgtctactgg gaaggtccca ggtcttcacc     1920

agttttacaa tgagttatcc caggccagac gtggtagctc acacctgtaa tcccagaact     1980

ttgggaggcc gaggtgggag gagcgcttga gccgaggagt tcaagaccag cctgggtatc     2040

acagggagac cccgtctcta caaaataaaa aaataattca ctgggaaaaa aaaaaaaaaa     2100

aaa                                                                   2103


<210>  28
<211>  514
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Leu Met Gln Glu Leu Tyr Ser Thr Pro Ala Ser Arg Leu Asp 
1               5                   10                  15      


Ser Phe Val Ala Gln Trp Leu Gln Pro His Arg Glu Trp Lys Glu Glu 
            20                  25                  30          


Val Leu Asp Ala Val Arg Thr Val Glu Glu Phe Leu Arg Gln Glu His 
        35                  40                  45              


Phe Gln Gly Lys Arg Gly Leu Asp Gln Asp Val Arg Val Leu Lys Val 
    50                  55                  60                  


Val Lys Val Gly Ser Phe Gly Asn Gly Thr Val Leu Arg Ser Thr Arg 
65                  70                  75                  80  


Glu Val Glu Leu Val Ala Phe Leu Ser Cys Phe His Ser Phe Gln Glu 
                85                  90                  95      


Ala Ala Lys His His Lys Asp Val Leu Arg Leu Ile Trp Lys Thr Met 
            100                 105                 110         


Trp Gln Ser Gln Asp Leu Leu Asp Leu Gly Leu Glu Asp Leu Arg Met 
        115                 120                 125             


Glu Gln Arg Val Pro Asp Ala Leu Val Phe Thr Ile Gln Thr Arg Gly 
    130                 135                 140                 


Thr Ala Glu Pro Ile Thr Val Thr Ile Val Pro Ala Tyr Arg Ala Leu 
145                 150                 155                 160 


Gly Pro Ser Leu Pro Asn Ser Gln Pro Pro Pro Glu Val Tyr Val Ser 
                165                 170                 175     


Leu Ile Lys Ala Cys Gly Gly Pro Gly Asn Phe Cys Pro Ser Phe Ser 
            180                 185                 190         


Glu Leu Gln Arg Asn Phe Val Lys His Arg Pro Thr Lys Leu Lys Ser 
        195                 200                 205             


Leu Leu Arg Leu Val Lys His Trp Tyr Gln Gln Tyr Val Lys Ala Arg 
    210                 215                 220                 


Ser Pro Arg Ala Asn Leu Pro Pro Leu Tyr Ala Leu Glu Leu Leu Thr 
225                 230                 235                 240 


Ile Tyr Ala Trp Glu Met Gly Thr Glu Glu Asp Glu Asn Phe Met Leu 
                245                 250                 255     


Asp Glu Gly Phe Thr Thr Val Met Asp Leu Leu Leu Glu Tyr Glu Val 
            260                 265                 270         


Ile Cys Ile Tyr Trp Thr Lys Tyr Tyr Thr Leu His Asn Ala Ile Ile 
        275                 280                 285             


Glu Asp Cys Val Arg Lys Gln Leu Lys Lys Glu Arg Pro Ile Ile Leu 
    290                 295                 300                 


Asp Pro Ala Asp Pro Thr Leu Asn Val Ala Glu Gly Tyr Arg Trp Asp 
305                 310                 315                 320 


Ile Val Ala Gln Arg Ala Ser Gln Cys Leu Lys Gln Asp Cys Cys Tyr 
                325                 330                 335     


Asp Asn Arg Glu Asn Pro Ile Ser Ser Trp Asn Val Lys Arg Ala Arg 
            340                 345                 350         


Asp Ile His Leu Thr Val Glu Gln Arg Gly Tyr Pro Asp Phe Asn Leu 
        355                 360                 365             


Ile Val Asn Pro Tyr Glu Pro Ile Arg Lys Val Lys Glu Lys Ile Arg 
    370                 375                 380                 


Arg Thr Arg Gly Tyr Ser Gly Leu Gln Arg Leu Ser Phe Gln Val Pro 
385                 390                 395                 400 


Gly Ser Glu Arg Gln Leu Leu Ser Ser Arg Cys Ser Leu Ala Lys Tyr 
                405                 410                 415     


Gly Ile Phe Ser His Thr His Ile Tyr Leu Leu Glu Thr Ile Pro Ser 
            420                 425                 430         


Glu Ile Gln Val Phe Val Lys Asn Pro Asp Gly Gly Ser Tyr Ala Tyr 
        435                 440                 445             


Ala Ile Asn Pro Asn Ser Phe Ile Leu Gly Leu Lys Gln Gln Ile Glu 
    450                 455                 460                 


Asp Gln Gln Gly Leu Pro Lys Lys Gln Gln Gln Leu Glu Phe Gln Gly 
465                 470                 475                 480 


Gln Val Leu Gln Asp Trp Leu Gly Leu Gly Ile Tyr Gly Ile Gln Asp 
                485                 490                 495     


Ser Asp Thr Leu Ile Leu Ser Lys Lys Lys Gly Glu Ala Leu Phe Pro 
            500                 505                 510         


Ala Ser 
        


<210>  29
<211>  1861
<212>  DNA
<213>  Homo sapiens

<400>  29
tgactagacg gccagcctgt taaggtggcc ccagatattc cagcctcagc ccagagtcct       60

cctgtgcccc tactgcagca agggtgtctc caagaagggg gacctggagt cagcccgtca      120

cacctggttt cctctctgct agggtccctc ctcccacaga gcactggagg gcagctgagg      180

aggagctacc ttaaaaaagg aggtgtgtgc cagggagctg ggtaggagcc tggctatata      240

tctgcccagc agcggtactc tcgggacaga gatggcactg atgcaggaac tgtatagcac      300

accagcctcc aggctggact ccttcgtggc tcagtggctg cagccccacc gggagtggaa      360

ggaagaggtg ctagacgctg tgcggaccgt ggaggagttt ctgaggcagg agcatttcca      420

ggggaagcgt gggctggacc aggatgtgcg ggtgctgaag gtagtcaagg tgggctcctt      480

cgggaatggc acggttctca ggagcaccag agaggtggag ctggtggcgt ttctgagctg      540

tttccacagc ttccaggagg cagccaagca tcacaaagat gttctgaggc tgatatggaa      600

aaccatgtgg caaagccagg acctgctgga cctcgggctc gaggacctga ggatggagca      660

gagagtcccc gatgctctcg tcttcaccat ccagaccagg gggactgcgg agcccatcac      720

ggtcaccatt gtgcctgcct acagagccct ggggccttct cttcccaact cccagccacc      780

ccctgaggtc tatgtgagcc tgatcaaggc ctgcggtggt cctggaaatt tctgcccatc      840

cttcagcgag ctgcagagaa atttcgtgaa acatcggcca actaagctga agagcctcct      900

gcgcctggtg aaacactggt accagcaggc ccatcatcct ggatccggcc gaccccaccc      960

tcaacgtggc agaagggtac agatgggaca tcgttgctca gagggcctcc cagtgcctga     1020

aacaggactg ttgctatgac aacagggaga accccatctc cagctggaac gtgaagaggg     1080

cacgagacat ccacttgaca gtggagcaga ggggttaccc agatttcaac ctcatcgtga     1140

acccttatga gcccataagg aaggttaaag agaaaatccg gaggaccagg ggctactctg     1200

gcctgcagcg tctgtccttc caggttcctg gcagtgagag gcagcttctc agcagcaggt     1260

gctccttagc caaatatggg atcttctccc acactcacat ctatctgctg gagaccatcc     1320

cctccgagat ccaggtcttc gtgaagaatc ctgatggtgg gagctacgcc tatgccatca     1380

accccaacag cttcatcctg ggtctgaagc agcagattga agaccagcag gggcttccta     1440

aaaagcagca gcagctggaa ttccaaggcc aagtcctgca ggactggttg ggtctgggga     1500

tctatggcat ccaagacagt gacactctca tcctctcgaa gaagaaagga gaggctctgt     1560

ttccagccag ttagttttct ctgggagact tctctgtaca tttctgccat gtactccaga     1620

actcatcctg tcaatcactc tgtcccattg tctactggga aggtcccagg tcttcaccag     1680

ttttacaatg agttatccca ggccagacgt ggtagctcac acctgtaatc ccagaacttt     1740

gggaggccga ggtgggagga gcgcttgagc cgaggagttc aagaccagcc tgggtatcac     1800

agggagaccc cgtctctaca aaataaaaaa ataattcact gggaaaaaaa aaaaaaaaaa     1860

a                                                                     1861


<210>  30
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Leu Met Gln Glu Leu Tyr Ser Thr Pro Ala Ser Arg Leu Asp 
1               5                   10                  15      


Ser Phe Val Ala Gln Trp Leu Gln Pro His Arg Glu Trp Lys Glu Glu 
            20                  25                  30          


Val Leu Asp Ala Val Arg Thr Val Glu Glu Phe Leu Arg Gln Glu His 
        35                  40                  45              


Phe Gln Gly Lys Arg Gly Leu Asp Gln Asp Val Arg Val Leu Lys Val 
    50                  55                  60                  


Val Lys Val Gly Ser Phe Gly Asn Gly Thr Val Leu Arg Ser Thr Arg 
65                  70                  75                  80  


Glu Val Glu Leu Val Ala Phe Leu Ser Cys Phe His Ser Phe Gln Glu 
                85                  90                  95      


Ala Ala Lys His His Lys Asp Val Leu Arg Leu Ile Trp Lys Thr Met 
            100                 105                 110         


Trp Gln Ser Gln Asp Leu Leu Asp Leu Gly Leu Glu Asp Leu Arg Met 
        115                 120                 125             


Glu Gln Arg Val Pro Asp Ala Leu Val Phe Thr Ile Gln Thr Arg Gly 
    130                 135                 140                 


Thr Ala Glu Pro Ile Thr Val Thr Ile Val Pro Ala Tyr Arg Ala Leu 
145                 150                 155                 160 


Gly Pro Ser Leu Pro Asn Ser Gln Pro Pro Pro Glu Val Tyr Val Ser 
                165                 170                 175     


Leu Ile Lys Ala Cys Gly Gly Pro Gly Asn Phe Cys Pro Ser Phe Ser 
            180                 185                 190         


Glu Leu Gln Arg Asn Phe Val Lys His Arg Pro Thr Lys Leu Lys Ser 
        195                 200                 205             


Leu Leu Arg Leu Val Lys His Trp Tyr Gln Gln Ala His His Pro Gly 
    210                 215                 220                 


Ser Gly Arg Pro His Pro Gln Arg Gly Arg Arg Val Gln Met Gly His 
225                 230                 235                 240 


Arg Cys Ser Glu Gly Leu Pro Val Pro Glu Thr Gly Leu Leu Leu 
                245                 250                 255 


<210>  31
<211>  1240
<212>  DNA
<213>  Homo sapiens

<400>  31
ttatgggttt catttagtgg agaaattggg tatgacctcg gaggagtcaa gaaagagttc       60

ttctactgtc tgtttgcaga gatgatccag ccggaatatg ggatgttcat gtatcctgaa      120

ggggcttcct gcatgtggtt tcctgtcaag cctaaatttg agaagaaaag atacttcttt      180

tttggggttc tatgtggact ttccctgttc aattgcaatg ttgccaacct tcctttccca      240

ctggcactgt ttaagaaact tttggaccaa atgccatcat tggaagactt gaaagaactc      300

agtcctgatt tgggaaagaa tttgcaaaca cttctggatg atgaaggtga taactttgag      360

gaagtatttt acatccattt taatgtgcac tgggacagaa acgacacaaa cttaattcct      420

aatggaagta gcataactgt caaccagact aacaagagag actatgtttc taagtatatc      480

aattacattt tcaacgactc tgtaaaggcg gtttatgaag aatttcggag aggattttat      540

aaaatgtgcg acgaagacat tatcaaatta ttccaccccg aagaactgaa ggatgtgatt      600

gttggaaata cagattatga ttggaaaaca tttgaaaaga atgcacgtta tgaaccagga      660

tataacagtt cacatcccac catagtgatg ttttggaagg ctttccacaa attgactctg      720

gaagaaaaga aaaaattcct tgtatttctt acaggaactg acagactaca aatgaaagat      780

ttaaataata tgaaaataac attttgctgt cctgaaagtt ggaatgaaag agaccctata      840

agagcactga catgtttcag tgtcctcttc ctccctaaat attctacaat ggaaacagtt      900

gaagaagcgc ttcaagaagc catcaacaac aacagaggat ttggctgacc agcttgcttg      960

tccaacagcc ttattttgtt gttgttatcg ttgttgttgt tgttgttgtt gttgtttctc     1020

tactttgttt tgttttaggc ttttagcagc ctgaagccat ggtttttcat ttctgtctct     1080

agtgataagc aggaaagagg gatgaagaag agggtttact ggccggttag aacccgtgac     1140

tgtattctct cccttggata cccctatgcc tacatcatat tccttacctc ttttgggaaa     1200

tatttttcaa aaataaaata accgaaaaat taacataaaa                           1240


<210>  32
<211>  1024
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Glu Arg Arg Ser Arg Arg Lys Ser Arg Arg Asn Gly Arg Ser Thr 
1               5                   10                  15      


Ala Gly Lys Ala Ala Ala Thr Gln Pro Ala Lys Ser Pro Gly Ala Gln 
            20                  25                  30          


Leu Trp Leu Phe Pro Ser Ala Ala Gly Leu His Arg Ala Leu Leu Arg 
        35                  40                  45              


Arg Val Glu Val Thr Arg Gln Leu Cys Cys Ser Pro Gly Arg Leu Ala 
    50                  55                  60                  


Val Leu Glu Arg Gly Gly Ala Gly Val Gln Val His Gln Leu Leu Ala 
65                  70                  75                  80  


Gly Ser Gly Gly Ala Arg Thr Pro Lys Cys Ile Lys Leu Gly Lys Asn 
                85                  90                  95      


Met Lys Ile His Ser Val Asp Gln Gly Ala Glu His Met Leu Ile Leu 
            100                 105                 110         


Ser Ser Asp Gly Lys Pro Phe Glu Tyr Asp Asn Tyr Ser Met Lys His 
        115                 120                 125             


Leu Arg Phe Glu Ser Ile Leu Gln Glu Lys Lys Ile Ile Gln Ile Thr 
    130                 135                 140                 


Cys Gly Asp Tyr His Ser Leu Ala Leu Ser Lys Gly Gly Glu Leu Phe 
145                 150                 155                 160 


Ala Trp Gly Gln Asn Leu His Gly Gln Leu Gly Val Gly Arg Lys Phe 
                165                 170                 175     


Pro Ser Thr Thr Thr Pro Gln Ile Val Glu His Leu Ala Gly Val Pro 
            180                 185                 190         


Leu Ala Gln Ile Ser Ala Gly Glu Ala His Ser Met Ala Leu Ser Met 
        195                 200                 205             


Ser Gly Asn Ile Tyr Ser Trp Gly Lys Asn Glu Cys Gly Gln Leu Gly 
    210                 215                 220                 


Leu Gly His Thr Glu Ser Lys Asp Asp Pro Ser Leu Ile Glu Gly Leu 
225                 230                 235                 240 


Asp Asn Gln Lys Val Glu Phe Val Ala Cys Gly Gly Ser His Ser Ala 
                245                 250                 255     


Leu Leu Thr Gln Asp Gly Leu Leu Phe Thr Phe Gly Ala Gly Lys His 
            260                 265                 270         


Gly Gln Leu Gly His Asn Ser Thr Gln Asn Glu Leu Arg Pro Cys Leu 
        275                 280                 285             


Val Ala Glu Leu Val Gly Tyr Arg Val Thr Gln Ile Ala Cys Gly Arg 
    290                 295                 300                 


Trp His Thr Leu Ala Tyr Val Ser Asp Leu Gly Lys Val Phe Ser Phe 
305                 310                 315                 320 


Gly Ser Gly Lys Asp Gly Gln Leu Gly Asn Gly Gly Thr Arg Asp Gln 
                325                 330                 335     


Leu Met Pro Leu Pro Val Lys Val Ser Ser Ser Glu Glu Leu Lys Leu 
            340                 345                 350         


Glu Ser His Thr Ser Glu Lys Glu Leu Ile Met Ile Ala Gly Gly Asn 
        355                 360                 365             


Gln Ser Ile Leu Leu Trp Ile Lys Lys Glu Asn Ser Tyr Val Asn Leu 
    370                 375                 380                 


Lys Arg Thr Ile Pro Thr Leu Asn Glu Gly Thr Val Lys Arg Trp Ile 
385                 390                 395                 400 


Ala Asp Val Glu Thr Lys Arg Trp Gln Ser Thr Lys Arg Glu Ile Gln 
                405                 410                 415     


Glu Ile Phe Ser Ser Pro Ala Cys Leu Thr Gly Ser Phe Leu Arg Lys 
            420                 425                 430         


Arg Arg Thr Thr Glu Met Met Pro Val Tyr Leu Asp Leu Asn Lys Ala 
        435                 440                 445             


Arg Asn Ile Phe Lys Glu Leu Thr Gln Lys Asp Trp Ile Thr Asn Met 
    450                 455                 460                 


Ile Thr Thr Cys Leu Lys Asp Asn Leu Leu Lys Arg Leu Pro Phe His 
465                 470                 475                 480 


Ser Pro Pro Gln Glu Ala Leu Glu Ile Phe Phe Leu Leu Pro Glu Cys 
                485                 490                 495     


Pro Met Met His Ile Ser Asn Asn Trp Glu Ser Leu Val Val Pro Phe 
            500                 505                 510         


Ala Lys Val Val Cys Lys Met Ser Asp Gln Ser Ser Leu Val Leu Glu 
        515                 520                 525             


Glu Tyr Trp Ala Thr Leu Gln Glu Ser Thr Phe Ser Lys Leu Val Gln 
    530                 535                 540                 


Met Phe Lys Thr Ala Val Ile Cys Gln Leu Asp Tyr Trp Asp Glu Ser 
545                 550                 555                 560 


Ala Glu Glu Asn Gly Asn Val Gln Ala Leu Leu Glu Met Leu Lys Lys 
                565                 570                 575     


Leu His Arg Val Asn Gln Val Lys Cys Gln Leu Pro Glu Ser Ile Phe 
            580                 585                 590         


Gln Val Asp Glu Leu Leu His Arg Leu Asn Phe Phe Val Glu Val Cys 
        595                 600                 605             


Arg Arg Tyr Leu Trp Lys Met Thr Val Asp Ala Ser Glu Asn Val Gln 
    610                 615                 620                 


Cys Cys Val Ile Phe Ser His Phe Pro Phe Ile Phe Asn Asn Leu Ser 
625                 630                 635                 640 


Lys Ile Lys Leu Leu His Thr Asp Thr Leu Leu Lys Ile Glu Ser Lys 
                645                 650                 655     


Lys His Lys Ala Tyr Leu Arg Ser Ala Ala Ile Glu Glu Glu Arg Glu 
            660                 665                 670         


Ser Glu Phe Ala Leu Arg Pro Thr Phe Asp Leu Thr Val Arg Arg Asn 
        675                 680                 685             


His Leu Ile Glu Asp Val Leu Asn Gln Leu Ser Gln Phe Glu Asn Glu 
    690                 695                 700                 


Asp Leu Arg Lys Glu Leu Trp Val Ser Phe Ser Gly Glu Ile Gly Tyr 
705                 710                 715                 720 


Asp Leu Gly Gly Val Lys Lys Glu Phe Phe Tyr Cys Leu Phe Ala Glu 
                725                 730                 735     


Met Ile Gln Pro Glu Tyr Gly Met Phe Met Tyr Pro Glu Gly Ala Ser 
            740                 745                 750         


Cys Met Trp Phe Pro Val Lys Pro Lys Phe Glu Lys Lys Arg Tyr Phe 
        755                 760                 765             


Phe Phe Gly Val Leu Cys Gly Leu Ser Leu Phe Asn Cys Asn Val Ala 
    770                 775                 780                 


Asn Leu Pro Phe Pro Leu Ala Leu Phe Lys Lys Leu Leu Asp Gln Met 
785                 790                 795                 800 


Pro Ser Leu Glu Asp Leu Lys Glu Leu Ser Pro Asp Leu Gly Lys Asn 
                805                 810                 815     


Leu Gln Thr Leu Leu Asp Asp Glu Gly Asp Asn Phe Glu Glu Val Phe 
            820                 825                 830         


Tyr Ile His Phe Asn Val His Trp Asp Arg Asn Asp Thr Asn Leu Ile 
        835                 840                 845             


Pro Asn Gly Ser Ser Ile Thr Val Asn Gln Thr Asn Lys Arg Asp Tyr 
    850                 855                 860                 


Val Ser Lys Tyr Ile Asn Tyr Ile Phe Asn Asp Ser Val Lys Ala Val 
865                 870                 875                 880 


Tyr Glu Glu Phe Arg Arg Gly Phe Tyr Lys Met Cys Asp Glu Asp Ile 
                885                 890                 895     


Ile Lys Leu Phe His Pro Glu Glu Leu Lys Asp Val Ile Val Gly Asn 
            900                 905                 910         


Thr Asp Tyr Asp Trp Lys Thr Phe Glu Lys Asn Ala Arg Tyr Glu Pro 
        915                 920                 925             


Gly Tyr Asn Ser Ser His Pro Thr Ile Val Met Phe Trp Lys Ala Phe 
    930                 935                 940                 


His Lys Leu Thr Leu Glu Glu Lys Lys Lys Phe Leu Val Phe Leu Thr 
945                 950                 955                 960 


Gly Thr Asp Arg Leu Gln Met Lys Asp Leu Asn Asn Met Lys Ile Thr 
                965                 970                 975     


Phe Cys Cys Pro Glu Ser Trp Asn Glu Arg Asp Pro Ile Arg Ala Leu 
            980                 985                 990         


Thr Cys Phe Ser Val Leu Phe Leu  Pro Lys Tyr Ser Thr  Met Glu Thr 
        995                 1000                 1005             


Val Glu  Glu Ala Leu Gln Glu  Ala Ile Asn Asn Asn  Arg Gly Phe 
    1010                 1015                 1020             


Gly 
    


<210>  33
<211>  2037
<212>  DNA
<213>  Homo sapiens

<400>  33
gggaagctcg ggccggcagg gtttccccgc acgctggcgc ccagctcccg gcgcggaggc       60

cgctgtaagt ttcgctttcc attcagtgga aaacgaaagc tgggcggggt gccacgagcg      120

cggggccaga ccaaggcggg cccggagcgg aacttcggtc ccagctcggt ccccggctca      180

gtcccgacgt ggaactcagc agcggaggct ggacgcttgc atggcgcttg agagattcca      240

tcgtgcctgg ctcacataag cgcttcctgg aagtgaagtc gtgctgtcct gaacgcgggc      300

caggcagctg cggcctgggg gttttggagt gatcacgaat gagcaaggcg tttgggctcc      360

tgaggcaaat ctgtcagtcc atcctggctg agtcctcgca gtccccggca gatcttgaag      420

aaaagaagga agaagacagc aacatgaaga gagagcagcc cagagagcgt cccagggcct      480

gggactaccc tcatggcctg gttggtttac acaacattgg acagacctgc tgccttaact      540

ccttgattca ggtgttcgta atgaatgtgg acttcaccag gatattgaag aggatcacgg      600

tgcccagggg agctgacgag cagaggagaa gcgtcccttt ccagatgctt ctgctgctgg      660

agaagatgca ggacagccgg cagaaagcag tgcggcccct ggagctggcc tactgcctgc      720

agaagtgcaa cgtgcccttg tttgtccaac atgatgctgc ccaactgtac ctcaaactct      780

ggaacctgat taaggaccag atcactgatg tgcacttggt ggagagactg caggccctgt      840

atacgatccg ggtgaaggac tccttgattt gcgttgactg tgccatggag agtagcagaa      900

acagcagcat gctcaccctc ccactttctc tttttgatgt ggactcaaag cccctgaaga      960

cactggagga cgccctgcac tgcttcttcc agcccaggga gttatcaagc aaaagcaagt     1020

gcttctgtga gaactgtggg aagaagaccc gtgggaaaca ggtcttgaag ctgacccatt     1080

tgccccagac cctgacaatc cacctcatgc gattctccat caggaattca cagacgagaa     1140

agatctgcca ctccctgtac ttcccccaga gcttggattt cagccagatc cttccaatga     1200

agcgagagtc ttgtgatgct gaggagcagt ctggagggca gtatgagctt tttgctgtga     1260

ttgcgcacgt gggaatggca gactccggtc attactgtgt ctacatccgg aatgctgtgg     1320

atggaaaatg gttctgcttc aatgactcca atatttgctt ggtgtcctgg gaagacatcc     1380

agtgtaccta cggaaatcct aactaccact ggcaggaaac tgcatatctt ctggtttaca     1440

tgaagatgga gtgctaatgg aaatgcccaa aaccttcaga gattgacacg ctgtcatttt     1500

ccatttccgt tcctggatct acggagtctt ctaagagatt ttgcaatgag gagaagcatt     1560

gttttcaaac tatataactg agccttattt ataattaggg atattatcaa aatatgtaac     1620

catgaggccc ctcaggtcct gatcagtcag aatggatgct ttcaccagca gacccggcca     1680

tgtggctgct cggtcctggg tgctcgctgc tgtgcaagac attagccctt tagttatgag     1740

cctgtgggaa cttcaggggt tcccagtggg gagagcagtg gcagtgggag gcatctgggg     1800

gccaaaggtc agtggcaggg ggtatttcag tattatacaa ctgctgtgac cagacttgta     1860

tactggctga atatcagtgc tgtttgtaat ttttcacttt gagaaccaac attaattcca     1920

tatgaatcaa gtgttttgta actgctattc atttattcag caaatattta ttgatcatct     1980

cttctccata agatagtgtg ataaacacag tcatgaataa agttattttc cacaaaa        2037


<210>  34
<211>  372
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ser Lys Ala Phe Gly Leu Leu Arg Gln Ile Cys Gln Ser Ile Leu 
1               5                   10                  15      


Ala Glu Ser Ser Gln Ser Pro Ala Asp Leu Glu Glu Lys Lys Glu Glu 
            20                  25                  30          


Asp Ser Asn Met Lys Arg Glu Gln Pro Arg Glu Arg Pro Arg Ala Trp 
        35                  40                  45              


Asp Tyr Pro His Gly Leu Val Gly Leu His Asn Ile Gly Gln Thr Cys 
    50                  55                  60                  


Cys Leu Asn Ser Leu Ile Gln Val Phe Val Met Asn Val Asp Phe Thr 
65                  70                  75                  80  


Arg Ile Leu Lys Arg Ile Thr Val Pro Arg Gly Ala Asp Glu Gln Arg 
                85                  90                  95      


Arg Ser Val Pro Phe Gln Met Leu Leu Leu Leu Glu Lys Met Gln Asp 
            100                 105                 110         


Ser Arg Gln Lys Ala Val Arg Pro Leu Glu Leu Ala Tyr Cys Leu Gln 
        115                 120                 125             


Lys Cys Asn Val Pro Leu Phe Val Gln His Asp Ala Ala Gln Leu Tyr 
    130                 135                 140                 


Leu Lys Leu Trp Asn Leu Ile Lys Asp Gln Ile Thr Asp Val His Leu 
145                 150                 155                 160 


Val Glu Arg Leu Gln Ala Leu Tyr Thr Ile Arg Val Lys Asp Ser Leu 
                165                 170                 175     


Ile Cys Val Asp Cys Ala Met Glu Ser Ser Arg Asn Ser Ser Met Leu 
            180                 185                 190         


Thr Leu Pro Leu Ser Leu Phe Asp Val Asp Ser Lys Pro Leu Lys Thr 
        195                 200                 205             


Leu Glu Asp Ala Leu His Cys Phe Phe Gln Pro Arg Glu Leu Ser Ser 
    210                 215                 220                 


Lys Ser Lys Cys Phe Cys Glu Asn Cys Gly Lys Lys Thr Arg Gly Lys 
225                 230                 235                 240 


Gln Val Leu Lys Leu Thr His Leu Pro Gln Thr Leu Thr Ile His Leu 
                245                 250                 255     


Met Arg Phe Ser Ile Arg Asn Ser Gln Thr Arg Lys Ile Cys His Ser 
            260                 265                 270         


Leu Tyr Phe Pro Gln Ser Leu Asp Phe Ser Gln Ile Leu Pro Met Lys 
        275                 280                 285             


Arg Glu Ser Cys Asp Ala Glu Glu Gln Ser Gly Gly Gln Tyr Glu Leu 
    290                 295                 300                 


Phe Ala Val Ile Ala His Val Gly Met Ala Asp Ser Gly His Tyr Cys 
305                 310                 315                 320 


Val Tyr Ile Arg Asn Ala Val Asp Gly Lys Trp Phe Cys Phe Asn Asp 
                325                 330                 335     


Ser Asn Ile Cys Leu Val Ser Trp Glu Asp Ile Gln Cys Thr Tyr Gly 
            340                 345                 350         


Asn Pro Asn Tyr His Trp Gln Glu Thr Ala Tyr Leu Leu Val Tyr Met 
        355                 360                 365             


Lys Met Glu Cys 
    370         


<210>  35
<211>  3512
<212>  DNA
<213>  Homo sapiens

<400>  35
aactcagctg agtgttagtc aaagaaggtg tgtcctgctc cccaatgaca ggttgctcag       60

agactgctga tttccatccc tatataaaga gagtccctgg catacagaga ctgctctgct      120

ccaggcatct gccacaatgt gggtgcttac acctgctgct tttgctggga agctcttgag      180

tgtgttcagg caacctctga gctctctgtg gaggagcctg gtcccgctgt tctgctggct      240

gagggcaacc ttctggctgc tagctaccaa gaggagaaag cagcagctgg tcctgagagg      300

gccagatgag accaaagagg aggaagagga ccctcctctg cccaccaccc caaccagcgt      360

caactatcac ttcactcgcc agtgcaacta caaatgcggc ttctgtttcc acacagccaa      420

aacatccttt gtgctgcccc ttgaggaagc aaagagagga ttgcttttgc ttaaggaagc      480

tggtatggag aagatcaact tttcaggtgg agagccattt cttcaagacc ggggagaata      540

cctgggcaag ttggtgaggt tctgcaaagt agagttgcgg ctgcccagcg tgagcatcgt      600

gagcaatgga agcctgatcc gggagaggtg gttccagaat tatggtgagt atttggacat      660

tctcgctatc tcctgtgaca gctttgacga ggaagtcaat gtccttattg gccgtggcca      720

aggaaagaag aaccatgtgg aaaaccttca aaagctgagg aggtggtgta gggattatag      780

agtcgctttc aagataaatt ctgtcattaa tcgtttcaac gtggaagagg acatgacgga      840

acagatcaaa gcactaaacc ctgtccgctg gaaagtgttc cagtgcctct taattgaggg      900

tgagaattgt ggagaagatg ctctaagaga agcagaaaga tttgttattg gtgatgaaga      960

atttgaaaga ttcttggagc gccacaaaga agtgtcctgc ttggtgcctg aatctaacca     1020

gaagatgaaa gactcctacc ttattctgga tgaatatatg cgctttctga actgtagaaa     1080

gggacggaag gacccttcca agtccatcct ggatgttggt gtagaagaag ctataaaatt     1140

cagtggattt gatgaaaaga tgtttctgaa gcgaggagga aaatacatat ggagtaaggc     1200

tgatctgaag ctggattggt agagcggaaa gtggaacgag acttcaacac accagtggga     1260

aaactcctag agtaactgcc attgtctgca atactatccc gttggtattt cccagtggct     1320

gaaaacctga ttttctgctg cacgtggcat ctgattacct gtggtcactg aacacacgaa     1380

taacttggat agcaaatcct gagacaatgg aaaaccatta actttacttc attggcttat     1440

aaccttgttg ttattgaaac agcacttctg tttttgagtt tgttttagct aaaaagaagg     1500

aatacacaca ggaataatga ccccaaaaat gcttagataa ggcccctata cacaggacct     1560

gacatttagc tcaatgatgc gtttgtaaga aataagctct agtgatatct gtgggggcaa     1620

aatttaattt ggatttgatt ttttaaaaca atgtttactg cgatttctat atttccattt     1680

tgaaactatt tcttgttcca ggtttgttca tttgacagag tcagtatttt ttgccaaata     1740

tccagataac cagttttcac atctgagaca ttacaaagta tctgcctcaa ttatttctgc     1800

tggttataat gctttttttt ttttgccttt atgccattgc agtcttgtac tttttactgt     1860

gatgtacaga aatagtcaac agatgtttcc aagaacatat gatatgataa tcctaccaat     1920

tttcaagaag tctctagaaa gagataacac atggaaagac ggtgtggtgc agcccagccc     1980

acggtggctg ttccatgaat gctggctacc tatgtgtgtg gtacctgttg tgtccctttc     2040

tcttcaaaga tcctgagcaa aacaaagata cgctttccat ttgatgatgg agttgacatg     2100

gaggcagtgc ttgcattgct ttgttcgcct atcatctggc cacatgaggc tgtcaagcaa     2160

aagaatagga gtgtagttga gtagctggtt ggccctacat ctctgagaag tgacggcaca     2220

ctgggttggc ataagatatc ctaaaatcac gctggaacct tgggcaagga agaatgtgag     2280

caagagtaga gagagtgcct ggatttcatg tcagtgaagc caagtcacca tatcatattt     2340

ttgaatgaac tctgagtcag ttgaaatagg gtaccatcta ggtcagttta agaagagtca     2400

gctcagagaa agcaagcata agggaaaatg tcacgtaaac tagatcaggg aacaaaatcc     2460

tctccttgtg gaaatatccc atgcagtttg ttgatacaac ttagtatctt attgcctaaa     2520

aaaaaatttc ttatcattgt ttcaaaaaag caaaatcatg gaaaattttt gttgtccagg     2580

caaataaaag gtcattttaa tttagctgca atttcagtgt tcctcactag gtggcattta     2640

aatgtcgcct gatgtcatta agcaccatcc aaaaagtctg cttcataatc tattttcaag     2700

acttggtgat tctgaaagtt ttggtttttg tgactttgtt tctcaggaaa aaaaatattc     2760

ctacttaaat tttaagtcta taattcaatt taaatatgtg tgtgtctcat ccaggatagg     2820

ataggttgtc ttctattttc cattttacct atttactttt tttgtaagaa aagagaaaaa     2880

tgaattctaa agatgttccc catgggtttt gattgtgtct aagctatgat gaccttcata     2940

taatcagcat aaacataaaa caaatttttt acttaacatg agtgcacttt actaatcctc     3000

atggcacagt ggctcacgcc tgtaatccca gcacttggga ggacaatgtg ggtggatcac     3060

gaggtcagga gttcgagaac agcctggcca acatggtgaa accccgtctc cactaaaaat     3120

acaaaaatta gccaggcatg gtggcgtaca cttgtaattc cagctactca agaggctgag     3180

gcaggaggat tgcttgaacc ctgaaggcag aggttacaga gccaagatag cgccactgca     3240

ctccagcctg gatgacagag caagactccg tctcaaaaaa aaaaaaaaaa aaaagcaaga     3300

gagttcaact aagaaaggtc acatatgtga aagcccaagg acactgtttg atatacagca     3360

ggtattcaat cagtgttatt tgaaaccaaa tctgaatttg aagtttgaat cttctgagtt     3420

ggaatgaatt tttttctagc tgagggaaac tgtatttttc tttccccaaa gaggaatgta     3480

atgtaaagtg aaataaaact ataagctatg tt                                   3512


<210>  36
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Trp Val Leu Thr Pro Ala Ala Phe Ala Gly Lys Leu Leu Ser Val 
1               5                   10                  15      


Phe Arg Gln Pro Leu Ser Ser Leu Trp Arg Ser Leu Val Pro Leu Phe 
            20                  25                  30          


Cys Trp Leu Arg Ala Thr Phe Trp Leu Leu Ala Thr Lys Arg Arg Lys 
        35                  40                  45              


Gln Gln Leu Val Leu Arg Gly Pro Asp Glu Thr Lys Glu Glu Glu Glu 
    50                  55                  60                  


Asp Pro Pro Leu Pro Thr Thr Pro Thr Ser Val Asn Tyr His Phe Thr 
65                  70                  75                  80  


Arg Gln Cys Asn Tyr Lys Cys Gly Phe Cys Phe His Thr Ala Lys Thr 
                85                  90                  95      


Ser Phe Val Leu Pro Leu Glu Glu Ala Lys Arg Gly Leu Leu Leu Leu 
            100                 105                 110         


Lys Glu Ala Gly Met Glu Lys Ile Asn Phe Ser Gly Gly Glu Pro Phe 
        115                 120                 125             


Leu Gln Asp Arg Gly Glu Tyr Leu Gly Lys Leu Val Arg Phe Cys Lys 
    130                 135                 140                 


Val Glu Leu Arg Leu Pro Ser Val Ser Ile Val Ser Asn Gly Ser Leu 
145                 150                 155                 160 


Ile Arg Glu Arg Trp Phe Gln Asn Tyr Gly Glu Tyr Leu Asp Ile Leu 
                165                 170                 175     


Ala Ile Ser Cys Asp Ser Phe Asp Glu Glu Val Asn Val Leu Ile Gly 
            180                 185                 190         


Arg Gly Gln Gly Lys Lys Asn His Val Glu Asn Leu Gln Lys Leu Arg 
        195                 200                 205             


Arg Trp Cys Arg Asp Tyr Arg Val Ala Phe Lys Ile Asn Ser Val Ile 
    210                 215                 220                 


Asn Arg Phe Asn Val Glu Glu Asp Met Thr Glu Gln Ile Lys Ala Leu 
225                 230                 235                 240 


Asn Pro Val Arg Trp Lys Val Phe Gln Cys Leu Leu Ile Glu Gly Glu 
                245                 250                 255     


Asn Cys Gly Glu Asp Ala Leu Arg Glu Ala Glu Arg Phe Val Ile Gly 
            260                 265                 270         


Asp Glu Glu Phe Glu Arg Phe Leu Glu Arg His Lys Glu Val Ser Cys 
        275                 280                 285             


Leu Val Pro Glu Ser Asn Gln Lys Met Lys Asp Ser Tyr Leu Ile Leu 
    290                 295                 300                 


Asp Glu Tyr Met Arg Phe Leu Asn Cys Arg Lys Gly Arg Lys Asp Pro 
305                 310                 315                 320 


Ser Lys Ser Ile Leu Asp Val Gly Val Glu Glu Ala Ile Lys Phe Ser 
                325                 330                 335     


Gly Phe Asp Glu Lys Met Phe Leu Lys Arg Gly Gly Lys Tyr Ile Trp 
            340                 345                 350         


Ser Lys Ala Asp Leu Lys Leu Asp Trp 
        355                 360     


<210>  37
<211>  2983
<212>  DNA
<213>  Homo sapiens

<400>  37
gttcgggccc gagaacctgc gtctcccgcg agttcccgcg aggcaagtgc tgcaggtgcg       60

gggccaggag ctaggtttcg tttctgcgcc cggagccgcc ctcagcacag ggtctgtgag      120

tttcatttct tcgcggcgcg gggcggggct gggcgcgggg tgaaagaggc gaagcgagag      180

cggaggccgc actccagcac tgcgcaggga ccgccttgga ccgcagttgc cggccaggaa      240

tcccagtgtc acggtggaca cgcctccctc gcgcccttgc cgcccacctg ctcacccagc      300

tcaggggctt tggaattctg tggccacact gcgaggagat cggttctggg tcggaggcta      360

caggaagact cccactccct gaaatctgga gtgaagaacg ccgccatcca gccaccattc      420

caaggaggtg caggagaaca gctctgtgat accatttaac ttgttgacat tacttttatt      480

tgaaggaacg tatattagag cttactttgc aaagaaggaa gatggttgtt tccgaagtgg      540

acatcgcaaa agctgatcca gctgctgcat cccaccctct attactgaat ggagatgcta      600

ctgtggccca gaaaaatcca ggctcggtgg ctgagaacaa cctgtgcagc cagtatgagg      660

agaaggtgcg cccctgcatc gacctcattg actccctgcg ggctctaggt gtggagcagg      720

acctggccct gccagccatc gccgtcatcg gggaccagag ctcgggcaag agctccgtgt      780

tggaggcact gtcaggagtt gcccttccca gaggcagcgg gatcgtgacc agatgcccgc      840

tggtgctgaa actgaagaaa cttgtgaacg aagataagtg gagaggcaag gtcagttacc      900

aggactacga gattgagatt tcggatgctt cagaggtaga aaaggaaatt aataaagccc      960

agaatgccat cgccggggaa ggaatgggaa tcagtcatga gctaatcacc ctggagatca     1020

gctcccgaga tgtcccggat ctgactctaa tagaccttcc tggcataacc agagtggctg     1080

tgggcaatca gcctgctgac attgggtata agatcaagac actcatcaag aagtacatcc     1140

agaggcagga gacaatcagc ctggtggtgg tccccagtaa tgtggacatc gccaccacag     1200

aggctctcag catggcccag gaggtggacc ccgagggaga caggaccatc ggaatcttga     1260

cgaagcctga tctggtggac aaaggaactg aagacaaggt tgtggacgtg gtgcggaacc     1320

tcgtgttcca cctgaagaag ggttacatga ttgtcaagtg ccggggccag caggagatcc     1380

aggaccagct gagcctgtcc gaagccctgc agagagagaa gatcttcttt gagaaccacc     1440

catatttcag ggatctgctg gaggaaggaa aggccacggt tccctgcctg gcagaaaaac     1500

ttaccagcga gctcatcaca catatctgta aatctctgcc cctgttagaa aatcaaatca     1560

aggagactca ccagagaata acagaggagc tacaaaagta tggtgtcgac ataccggaag     1620

acgaaaatga aaaaatgttc ttcctgatag ataaagttaa tgcctttaat caggacatca     1680

ctgctctcat gcaaggagag gaaactgtag gggaggaaga cattcggctg tttaccagac     1740

tccgacacga gttccacaaa tggagtacaa taattgaaaa caattttcaa gaaggccata     1800

aaattttgag tagaaaaatc cagaaatttg aaaatcagta tcgtggtaga gagctgccag     1860

gctttgtgaa ttacaggaca tttgagacaa tcgtgaaaca gcaaatcaag gcactggaag     1920

agccggctgt ggatatgcta cacaccgtga cggatatggt ccggcttgct ttcacagatg     1980

tttcgataaa aaattttgaa gagtttttta acctccacag aaccgccaag tccaaaattg     2040

aagacattag agcagaacaa gagagagaag gtgagaagct gatccgcctc cacttccaga     2100

tggaacagat tgtctactgc caggaccagg tatacagggg tgcattgcag aaggtcagag     2160

agaaggagct ggaagaagaa aagaagaaga aatcctggga ttttggggct ttccagtcca     2220

gctcggcaac agactcttcc atggaggaga tctttcagca cctgatggcc tatcaccagg     2280

aggccagcaa gcgcatctcc agccacatcc ctttgatcat ccagttcttc atgctccaga     2340

cgtacggcca gcagcttcag aaggccatgc tgcagctcct gcaggacaag gacacctaca     2400

gctggctcct gaaggagcgg agcgacacca gcgacaagcg gaagttcctg aaggagcggc     2460

ttgcacggct gacgcaggct cggcgccggc ttgcccagtt ccccggttaa ccacactctg     2520

tccagccccg tagacgtgca cgcacactgt ctgcccccgt tcccgggtag ccactggact     2580

gacgacttga gtgctcagta gtcagactgg atagtccgtc tctgcttatc cgttagccgt     2640

ggtgatttag caggaagctg tgagagcagt ttggtttcta gcatgaagac agagccccac     2700

cctcagatgc acatgagctg gcgggattga aggatgctgt cttcgtactg ggaaagggat     2760

tttcagccct cagaatcgct ccaccttgca gctctcccct tctctgtatt cctagaaact     2820

gacacatgct gaacatcaca gcttatttcc tcatttttat aatgtccctt cacaaaccca     2880

gtgttttagg agcatgagtg ccgtgtgtgt gcgtcctgtc ggagccctgt ctcctctctc     2940

tgtaataaac tcatttctag cagacaaaaa aaaaaaaaaa aaa                       2983


<210>  38
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Val Val Ser Glu Val Asp Ile Ala Lys Ala Asp Pro Ala Ala Ala 
1               5                   10                  15      


Ser His Pro Leu Leu Leu Asn Gly Asp Ala Thr Val Ala Gln Lys Asn 
            20                  25                  30          


Pro Gly Ser Val Ala Glu Asn Asn Leu Cys Ser Gln Tyr Glu Glu Lys 
        35                  40                  45              


Val Arg Pro Cys Ile Asp Leu Ile Asp Ser Leu Arg Ala Leu Gly Val 
    50                  55                  60                  


Glu Gln Asp Leu Ala Leu Pro Ala Ile Ala Val Ile Gly Asp Gln Ser 
65                  70                  75                  80  


Ser Gly Lys Ser Ser Val Leu Glu Ala Leu Ser Gly Val Ala Leu Pro 
                85                  90                  95      


Arg Gly Ser Gly Ile Val Thr Arg Cys Pro Leu Val Leu Lys Leu Lys 
            100                 105                 110         


Lys Leu Val Asn Glu Asp Lys Trp Arg Gly Lys Val Ser Tyr Gln Asp 
        115                 120                 125             


Tyr Glu Ile Glu Ile Ser Asp Ala Ser Glu Val Glu Lys Glu Ile Asn 
    130                 135                 140                 


Lys Ala Gln Asn Ala Ile Ala Gly Glu Gly Met Gly Ile Ser His Glu 
145                 150                 155                 160 


Leu Ile Thr Leu Glu Ile Ser Ser Arg Asp Val Pro Asp Leu Thr Leu 
                165                 170                 175     


Ile Asp Leu Pro Gly Ile Thr Arg Val Ala Val Gly Asn Gln Pro Ala 
            180                 185                 190         


Asp Ile Gly Tyr Lys Ile Lys Thr Leu Ile Lys Lys Tyr Ile Gln Arg 
        195                 200                 205             


Gln Glu Thr Ile Ser Leu Val Val Val Pro Ser Asn Val Asp Ile Ala 
    210                 215                 220                 


Thr Thr Glu Ala Leu Ser Met Ala Gln Glu Val Asp Pro Glu Gly Asp 
225                 230                 235                 240 


Arg Thr Ile Gly Ile Leu Thr Lys Pro Asp Leu Val Asp Lys Gly Thr 
                245                 250                 255     


Glu Asp Lys Val Val Asp Val Val Arg Asn Leu Val Phe His Leu Lys 
            260                 265                 270         


Lys Gly Tyr Met Ile Val Lys Cys Arg Gly Gln Gln Glu Ile Gln Asp 
        275                 280                 285             


Gln Leu Ser Leu Ser Glu Ala Leu Gln Arg Glu Lys Ile Phe Phe Glu 
    290                 295                 300                 


Asn His Pro Tyr Phe Arg Asp Leu Leu Glu Glu Gly Lys Ala Thr Val 
305                 310                 315                 320 


Pro Cys Leu Ala Glu Lys Leu Thr Ser Glu Leu Ile Thr His Ile Cys 
                325                 330                 335     


Lys Ser Leu Pro Leu Leu Glu Asn Gln Ile Lys Glu Thr His Gln Arg 
            340                 345                 350         


Ile Thr Glu Glu Leu Gln Lys Tyr Gly Val Asp Ile Pro Glu Asp Glu 
        355                 360                 365             


Asn Glu Lys Met Phe Phe Leu Ile Asp Lys Val Asn Ala Phe Asn Gln 
    370                 375                 380                 


Asp Ile Thr Ala Leu Met Gln Gly Glu Glu Thr Val Gly Glu Glu Asp 
385                 390                 395                 400 


Ile Arg Leu Phe Thr Arg Leu Arg His Glu Phe His Lys Trp Ser Thr 
                405                 410                 415     


Ile Ile Glu Asn Asn Phe Gln Glu Gly His Lys Ile Leu Ser Arg Lys 
            420                 425                 430         


Ile Gln Lys Phe Glu Asn Gln Tyr Arg Gly Arg Glu Leu Pro Gly Phe 
        435                 440                 445             


Val Asn Tyr Arg Thr Phe Glu Thr Ile Val Lys Gln Gln Ile Lys Ala 
    450                 455                 460                 


Leu Glu Glu Pro Ala Val Asp Met Leu His Thr Val Thr Asp Met Val 
465                 470                 475                 480 


Arg Leu Ala Phe Thr Asp Val Ser Ile Lys Asn Phe Glu Glu Phe Phe 
                485                 490                 495     


Asn Leu His Arg Thr Ala Lys Ser Lys Ile Glu Asp Ile Arg Ala Glu 
            500                 505                 510         


Gln Glu Arg Glu Gly Glu Lys Leu Ile Arg Leu His Phe Gln Met Glu 
        515                 520                 525             


Gln Ile Val Tyr Cys Gln Asp Gln Val Tyr Arg Gly Ala Leu Gln Lys 
    530                 535                 540                 


Val Arg Glu Lys Glu Leu Glu Glu Glu Lys Lys Lys Lys Ser Trp Asp 
545                 550                 555                 560 


Phe Gly Ala Phe Gln Ser Ser Ser Ala Thr Asp Ser Ser Met Glu Glu 
                565                 570                 575     


Ile Phe Gln His Leu Met Ala Tyr His Gln Glu Ala Ser Lys Arg Ile 
            580                 585                 590         


Ser Ser His Ile Pro Leu Ile Ile Gln Phe Phe Met Leu Gln Thr Tyr 
        595                 600                 605             


Gly Gln Gln Leu Gln Lys Ala Met Leu Gln Leu Leu Gln Asp Lys Asp 
    610                 615                 620                 


Thr Tyr Ser Trp Leu Leu Lys Glu Arg Ser Asp Thr Ser Asp Lys Arg 
625                 630                 635                 640 


Lys Phe Leu Lys Glu Arg Leu Ala Arg Leu Thr Gln Ala Arg Arg Arg 
                645                 650                 655     


Leu Ala Gln Phe Pro Gly 
            660         


<210>  39
<211>  2683
<212>  DNA
<213>  Homo sapiens

<400>  39
tttcttcgcg gcgcggggcg gggctgggcg cggggtgaaa gaggcgaagc gagagcggag       60

gccgcactcc agcactgcgc agggaccgga attctgtggc cacactgcga ggagatcggt      120

tctgggtcgg aggctacagg aagactccca ctccctgaaa tctggagtga agaacgccgc      180

catccagcca ccattccaag cttactttgc aaagaaggaa gatggttgtt tccgaagtgg      240

acatcgcaaa agctgatcca gctgctgcat cccaccctct attactgaat ggagatgcta      300

ctgtggccca gaaaaatcca ggctcggtgg ctgagaacaa cctgtgcagc cagtatgagg      360

agaaggtgcg cccctgcatc gacctcattg actccctgcg ggctctaggt gtggagcagg      420

acctggccct gccagccatc gccgtcatcg gggaccagag ctcgggcaag agctccgtgt      480

tggaggcact gtcaggagtt gcccttccca gaggcagcgg gatcgtgacc agatgcccgc      540

tggtgctgaa actgaagaaa cttgtgaacg aagataagtg gagaggcaag gtcagttacc      600

aggactacga gattgagatt tcggatgctt cagaggtaga aaaggaaatt aataaagccc      660

agaatgccat cgccggggaa ggaatgggaa tcagtcatga gctaatcacc ctggagatca      720

gctcccgaga tgtcccggat ctgactctaa tagaccttcc tggcataacc agagtggctg      780

tgggcaatca gcctgctgac attgggtata agatcaagac actcatcaag aagtacatcc      840

agaggcagga gacaatcagc ctggtggtgg tccccagtaa tgtggacatc gccaccacag      900

aggctctcag catggcccag gaggtggacc ccgagggaga caggaccatc ggaatcttga      960

cgaagcctga tctggtggac aaaggaactg aagacaaggt tgtggacgtg gtgcggaacc     1020

tcgtgttcca cctgaagaag ggttacatga ttgtcaagtg ccggggccag caggagatcc     1080

aggaccagct gagcctgtcc gaagccctgc agagagagaa gatcttcttt gagaaccacc     1140

catatttcag ggatctgctg gaggaaggaa aggccacggt tccctgcctg gcagaaaaac     1200

ttaccagcga gctcatcaca catatctgta aatctctgcc cctgttagaa aatcaaatca     1260

aggagactca ccagagaata acagaggagc tacaaaagta tggtgtcgac ataccggaag     1320

acgaaaatga aaaaatgttc ttcctgatag ataaagttaa tgcctttaat caggacatca     1380

ctgctctcat gcaaggagag gaaactgtag gggaggaaga cattcggctg tttaccagac     1440

tccgacacga gttccacaaa tggagtacaa taattgaaaa caattttcaa gaaggccata     1500

aaattttgag tagaaaaatc cagaaatttg aaaatcagta tcgtggtaga gagctgccag     1560

gctttgtgaa ttacaggaca tttgagacaa tcgtgaaaca gcaaatcaag gcactggaag     1620

agccggctgt ggatatgcta cacaccgtga cggatatggt ccggcttgct ttcacagatg     1680

tttcgataaa aaattttgaa gagtttttta acctccacag aaccgccaag tccaaaattg     1740

aagacattag agcagaacaa gagagagaag gtgagaagct gatccgcctc cacttccaga     1800

tggaacagat tgtctactgc caggaccagg tatacagggg tgcattgcag aaggtcagag     1860

agaaggagct ggaagaagaa aagaagaaga aatcctggga ttttggggct ttccagtcca     1920

gctcggcaac agactcttcc atggaggaga tctttcagca cctgatggcc tatcaccagg     1980

aggccagcaa gcgcatctcc agccacatcc ctttgatcat ccagttcttc atgctccaga     2040

cgtacggcca gcagcttcag aaggccatgc tgcagctcct gcaggacaag gacacctaca     2100

gctggctcct gaaggagcgg agcgacacca gcgacaagcg gaagttcctg aaggagcggc     2160

ttgcacggct gacgcaggct cggcgccggc ttgcccagtt ccccggttaa ccacactctg     2220

tccagccccg tagacgtgca cgcacactgt ctgcccccgt tcccgggtag ccactggact     2280

gacgacttga gtgctcagta gtcagactgg atagtccgtc tctgcttatc cgttagccgt     2340

ggtgatttag caggaagctg tgagagcagt ttggtttcta gcatgaagac agagccccac     2400

cctcagatgc acatgagctg gcgggattga aggatgctgt cttcgtactg ggaaagggat     2460

tttcagccct cagaatcgct ccaccttgca gctctcccct tctctgtatt cctagaaact     2520

gacacatgct gaacatcaca gcttatttcc tcatttttat aatgtccctt cacaaaccca     2580

gtgttttagg agcatgagtg ccgtgtgtgt gcgtcctgtc ggagccctgt ctcctctctc     2640

tgtaataaac tcatttctag cagacaaaaa aaaaaaaaaa aaa                       2683


<210>  40
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Val Val Ser Glu Val Asp Ile Ala Lys Ala Asp Pro Ala Ala Ala 
1               5                   10                  15      


Ser His Pro Leu Leu Leu Asn Gly Asp Ala Thr Val Ala Gln Lys Asn 
            20                  25                  30          


Pro Gly Ser Val Ala Glu Asn Asn Leu Cys Ser Gln Tyr Glu Glu Lys 
        35                  40                  45              


Val Arg Pro Cys Ile Asp Leu Ile Asp Ser Leu Arg Ala Leu Gly Val 
    50                  55                  60                  


Glu Gln Asp Leu Ala Leu Pro Ala Ile Ala Val Ile Gly Asp Gln Ser 
65                  70                  75                  80  


Ser Gly Lys Ser Ser Val Leu Glu Ala Leu Ser Gly Val Ala Leu Pro 
                85                  90                  95      


Arg Gly Ser Gly Ile Val Thr Arg Cys Pro Leu Val Leu Lys Leu Lys 
            100                 105                 110         


Lys Leu Val Asn Glu Asp Lys Trp Arg Gly Lys Val Ser Tyr Gln Asp 
        115                 120                 125             


Tyr Glu Ile Glu Ile Ser Asp Ala Ser Glu Val Glu Lys Glu Ile Asn 
    130                 135                 140                 


Lys Ala Gln Asn Ala Ile Ala Gly Glu Gly Met Gly Ile Ser His Glu 
145                 150                 155                 160 


Leu Ile Thr Leu Glu Ile Ser Ser Arg Asp Val Pro Asp Leu Thr Leu 
                165                 170                 175     


Ile Asp Leu Pro Gly Ile Thr Arg Val Ala Val Gly Asn Gln Pro Ala 
            180                 185                 190         


Asp Ile Gly Tyr Lys Ile Lys Thr Leu Ile Lys Lys Tyr Ile Gln Arg 
        195                 200                 205             


Gln Glu Thr Ile Ser Leu Val Val Val Pro Ser Asn Val Asp Ile Ala 
    210                 215                 220                 


Thr Thr Glu Ala Leu Ser Met Ala Gln Glu Val Asp Pro Glu Gly Asp 
225                 230                 235                 240 


Arg Thr Ile Gly Ile Leu Thr Lys Pro Asp Leu Val Asp Lys Gly Thr 
                245                 250                 255     


Glu Asp Lys Val Val Asp Val Val Arg Asn Leu Val Phe His Leu Lys 
            260                 265                 270         


Lys Gly Tyr Met Ile Val Lys Cys Arg Gly Gln Gln Glu Ile Gln Asp 
        275                 280                 285             


Gln Leu Ser Leu Ser Glu Ala Leu Gln Arg Glu Lys Ile Phe Phe Glu 
    290                 295                 300                 


Asn His Pro Tyr Phe Arg Asp Leu Leu Glu Glu Gly Lys Ala Thr Val 
305                 310                 315                 320 


Pro Cys Leu Ala Glu Lys Leu Thr Ser Glu Leu Ile Thr His Ile Cys 
                325                 330                 335     


Lys Ser Leu Pro Leu Leu Glu Asn Gln Ile Lys Glu Thr His Gln Arg 
            340                 345                 350         


Ile Thr Glu Glu Leu Gln Lys Tyr Gly Val Asp Ile Pro Glu Asp Glu 
        355                 360                 365             


Asn Glu Lys Met Phe Phe Leu Ile Asp Lys Val Asn Ala Phe Asn Gln 
    370                 375                 380                 


Asp Ile Thr Ala Leu Met Gln Gly Glu Glu Thr Val Gly Glu Glu Asp 
385                 390                 395                 400 


Ile Arg Leu Phe Thr Arg Leu Arg His Glu Phe His Lys Trp Ser Thr 
                405                 410                 415     


Ile Ile Glu Asn Asn Phe Gln Glu Gly His Lys Ile Leu Ser Arg Lys 
            420                 425                 430         


Ile Gln Lys Phe Glu Asn Gln Tyr Arg Gly Arg Glu Leu Pro Gly Phe 
        435                 440                 445             


Val Asn Tyr Arg Thr Phe Glu Thr Ile Val Lys Gln Gln Ile Lys Ala 
    450                 455                 460                 


Leu Glu Glu Pro Ala Val Asp Met Leu His Thr Val Thr Asp Met Val 
465                 470                 475                 480 


Arg Leu Ala Phe Thr Asp Val Ser Ile Lys Asn Phe Glu Glu Phe Phe 
                485                 490                 495     


Asn Leu His Arg Thr Ala Lys Ser Lys Ile Glu Asp Ile Arg Ala Glu 
            500                 505                 510         


Gln Glu Arg Glu Gly Glu Lys Leu Ile Arg Leu His Phe Gln Met Glu 
        515                 520                 525             


Gln Ile Val Tyr Cys Gln Asp Gln Val Tyr Arg Gly Ala Leu Gln Lys 
    530                 535                 540                 


Val Arg Glu Lys Glu Leu Glu Glu Glu Lys Lys Lys Lys Ser Trp Asp 
545                 550                 555                 560 


Phe Gly Ala Phe Gln Ser Ser Ser Ala Thr Asp Ser Ser Met Glu Glu 
                565                 570                 575     


Ile Phe Gln His Leu Met Ala Tyr His Gln Glu Ala Ser Lys Arg Ile 
            580                 585                 590         


Ser Ser His Ile Pro Leu Ile Ile Gln Phe Phe Met Leu Gln Thr Tyr 
        595                 600                 605             


Gly Gln Gln Leu Gln Lys Ala Met Leu Gln Leu Leu Gln Asp Lys Asp 
    610                 615                 620                 


Thr Tyr Ser Trp Leu Leu Lys Glu Arg Ser Asp Thr Ser Asp Lys Arg 
625                 630                 635                 640 


Lys Phe Leu Lys Glu Arg Leu Ala Arg Leu Thr Gln Ala Arg Arg Arg 
                645                 650                 655     


Leu Ala Gln Phe Pro Gly 
            660         


<210>  41
<211>  3409
<212>  DNA
<213>  Homo sapiens

<400>  41
aaattcgcgg tgggggcgga gagcgcaggg agaagtaagc ccagtgcagg atcctgaggc       60

ccgtgtttgc aggaccaggg ccggccttcc gattccccat tcattccaga agcaccgaac      120

cacgctgtgc ccggatccca agtgcagcgg cacccagcgt gggcctgggg ttgccggttg      180

acccggtcct cagcctggta gcagaggcca ggccagtgcc acaaggcacc taagtccacc      240

tgggcctgga gcaggacagg ttgcaaaaga aaatatctcg ggacccccaa actccttatg      300

ctaagggaaa catcgagcct gggaactgag ccatcaacgc tgccattctt tttcccaaac      360

agaaccctgt tgtcagaggt acacccagag caactccaca ccgggtgcat gccacagcaa      420

ctccatctta aataggagct ggtaaaacga ggctgatacc tactgggctg cattcccaga      480

cggcatagcg aggaggtgct gaagagcgca ggtttggaga atgatcacct ggattggaac      540

catagctcta ccaatatgga acccagctcc ttaggcctcg gtcttctcat ggagaacatg      600

gtgtgataat cctactcctc tgggagggtg gctgttaagc cttggaccgc agttgccggc      660

caggaatccc agtgtcacgg tggacacgcc tccctcgcgc ccttgccgcc cacctgctca      720

cccagctcag gggctttgga attctgtggc cacactgcga ggagatcggt tctgggtcgg      780

aggctacagg aagactccca ctccctgaaa tctggagtga agaacgccgc catccagcca      840

ccattccaag gaggtgcagg agaacagctc tgtgatacca tttaacttgt tgacattact      900

tttatttgaa ggaacgtata ttagagctta ctttgcaaag aaggaagatg gttgtttccg      960

aagtggacat cgcaaaagct gatccagctg ctgcatccca ccctctatta ctgaatggag     1020

atgctactgt ggcccagaaa aatccaggct cggtggctga gaacaacctg tgcagccagt     1080

atgaggagaa ggtgcgcccc tgcatcgacc tcattgactc cctgcgggct ctaggtgtgg     1140

agcaggacct ggccctgcca gccatcgccg tcatcgggga ccagagctcg ggcaagagct     1200

ccgtgttgga ggcactgtca ggagttgccc ttcccagagg cagcgggatc gtgaccagat     1260

gcccgctggt gctgaaactg aagaaacttg tgaacgaaga taagtggaga ggcaaggtca     1320

gttaccagga ctacgagatt gagatttcgg atgcttcaga ggtagaaaag gaaattaata     1380

aagcccagaa tgccatcgcc ggggaaggaa tgggaatcag tcatgagcta atcaccctgg     1440

agatcagctc ccgagatgtc ccggatctga ctctaataga ccttcctggc ataaccagag     1500

tggctgtggg caatcagcct gctgacattg ggtataagat caagacactc atcaagaagt     1560

acatccagag gcaggagaca atcagcctgg tggtggtccc cagtaatgtg gacatcgcca     1620

ccacagaggc tctcagcatg gcccaggagg tggaccccga gggagacagg accatcggaa     1680

tcttgacgaa gcctgatctg gtggacaaag gaactgaaga caaggttgtg gacgtggtgc     1740

ggaacctcgt gttccacctg aagaagggtt acatgattgt caagtgccgg ggccagcagg     1800

agatccagga ccagctgagc ctgtccgaag ccctgcagag agagaagatc ttctttgaga     1860

accacccata tttcagggat ctgctggagg aaggaaaggc cacggttccc tgcctggcag     1920

aaaaacttac cagcgagctc atcacacata tctgtaaatc tctgcccctg ttagaaaatc     1980

aaatcaagga gactcaccag agaataacag aggagctaca aaagtatggt gtcgacatac     2040

cggaagacga aaatgaaaaa atgttcttcc tgatagataa agttaatgcc tttaatcagg     2100

acatcactgc tctcatgcaa ggagaggaaa ctgtagggga ggaagacatt cggctgttta     2160

ccagactccg acacgagttc cacaaatgga gtacaataat tgaaaacaat tttcaagaag     2220

gccataaaat tttgagtaga aaaatccaga aatttgaaaa tcagtatcgt ggtagagagc     2280

tgccaggctt tgtgaattac aggacatttg agacaatcgt gaaacagcaa atcaaggcac     2340

tggaagagcc ggctgtggat atgctacaca ccgtgacgga tatggtccgg cttgctttca     2400

cagatgtttc gataaaaaat tttgaagagt tttttaacct ccacagaacc gccaagtcca     2460

aaattgaaga cattagagca gaacaagaga gagaaggtga gaagctgatc cgcctccact     2520

tccagatgga acagattgtc tactgccagg accaggtata caggggtgca ttgcagaagg     2580

tcagagagaa ggagctggaa gaagaaaaga agaagaaatc ctgggatttt ggggctttcc     2640

agtccagctc ggcaacagac tcttccatgg aggagatctt tcagcacctg atggcctatc     2700

accaggaggc cagcaagcgc atctccagcc acatcccttt gatcatccag ttcttcatgc     2760

tccagacgta cggccagcag cttcagaagg ccatgctgca gctcctgcag gacaaggaca     2820

cctacagctg gctcctgaag gagcggagcg acaccagcga caagcggaag ttcctgaagg     2880

agcggcttgc acggctgacg caggctcggc gccggcttgc ccagttcccc ggttaaccac     2940

actctgtcca gccccgtaga cgtgcacgca cactgtctgc ccccgttccc gggtagccac     3000

tggactgacg acttgagtgc tcagtagtca gactggatag tccgtctctg cttatccgtt     3060

agccgtggtg atttagcagg aagctgtgag agcagtttgg tttctagcat gaagacagag     3120

ccccaccctc agatgcacat gagctggcgg gattgaagga tgctgtcttc gtactgggaa     3180

agggattttc agccctcaga atcgctccac cttgcagctc tccccttctc tgtattccta     3240

gaaactgaca catgctgaac atcacagctt atttcctcat ttttataatg tcccttcaca     3300

aacccagtgt tttaggagca tgagtgccgt gtgtgtgcgt cctgtcggag ccctgtctcc     3360

tctctctgta ataaactcat ttctagcaga caaaaaaaaa aaaaaaaaa                 3409


<210>  42
<211>  662
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Val Val Ser Glu Val Asp Ile Ala Lys Ala Asp Pro Ala Ala Ala 
1               5                   10                  15      


Ser His Pro Leu Leu Leu Asn Gly Asp Ala Thr Val Ala Gln Lys Asn 
            20                  25                  30          


Pro Gly Ser Val Ala Glu Asn Asn Leu Cys Ser Gln Tyr Glu Glu Lys 
        35                  40                  45              


Val Arg Pro Cys Ile Asp Leu Ile Asp Ser Leu Arg Ala Leu Gly Val 
    50                  55                  60                  


Glu Gln Asp Leu Ala Leu Pro Ala Ile Ala Val Ile Gly Asp Gln Ser 
65                  70                  75                  80  


Ser Gly Lys Ser Ser Val Leu Glu Ala Leu Ser Gly Val Ala Leu Pro 
                85                  90                  95      


Arg Gly Ser Gly Ile Val Thr Arg Cys Pro Leu Val Leu Lys Leu Lys 
            100                 105                 110         


Lys Leu Val Asn Glu Asp Lys Trp Arg Gly Lys Val Ser Tyr Gln Asp 
        115                 120                 125             


Tyr Glu Ile Glu Ile Ser Asp Ala Ser Glu Val Glu Lys Glu Ile Asn 
    130                 135                 140                 


Lys Ala Gln Asn Ala Ile Ala Gly Glu Gly Met Gly Ile Ser His Glu 
145                 150                 155                 160 


Leu Ile Thr Leu Glu Ile Ser Ser Arg Asp Val Pro Asp Leu Thr Leu 
                165                 170                 175     


Ile Asp Leu Pro Gly Ile Thr Arg Val Ala Val Gly Asn Gln Pro Ala 
            180                 185                 190         


Asp Ile Gly Tyr Lys Ile Lys Thr Leu Ile Lys Lys Tyr Ile Gln Arg 
        195                 200                 205             


Gln Glu Thr Ile Ser Leu Val Val Val Pro Ser Asn Val Asp Ile Ala 
    210                 215                 220                 


Thr Thr Glu Ala Leu Ser Met Ala Gln Glu Val Asp Pro Glu Gly Asp 
225                 230                 235                 240 


Arg Thr Ile Gly Ile Leu Thr Lys Pro Asp Leu Val Asp Lys Gly Thr 
                245                 250                 255     


Glu Asp Lys Val Val Asp Val Val Arg Asn Leu Val Phe His Leu Lys 
            260                 265                 270         


Lys Gly Tyr Met Ile Val Lys Cys Arg Gly Gln Gln Glu Ile Gln Asp 
        275                 280                 285             


Gln Leu Ser Leu Ser Glu Ala Leu Gln Arg Glu Lys Ile Phe Phe Glu 
    290                 295                 300                 


Asn His Pro Tyr Phe Arg Asp Leu Leu Glu Glu Gly Lys Ala Thr Val 
305                 310                 315                 320 


Pro Cys Leu Ala Glu Lys Leu Thr Ser Glu Leu Ile Thr His Ile Cys 
                325                 330                 335     


Lys Ser Leu Pro Leu Leu Glu Asn Gln Ile Lys Glu Thr His Gln Arg 
            340                 345                 350         


Ile Thr Glu Glu Leu Gln Lys Tyr Gly Val Asp Ile Pro Glu Asp Glu 
        355                 360                 365             


Asn Glu Lys Met Phe Phe Leu Ile Asp Lys Val Asn Ala Phe Asn Gln 
    370                 375                 380                 


Asp Ile Thr Ala Leu Met Gln Gly Glu Glu Thr Val Gly Glu Glu Asp 
385                 390                 395                 400 


Ile Arg Leu Phe Thr Arg Leu Arg His Glu Phe His Lys Trp Ser Thr 
                405                 410                 415     


Ile Ile Glu Asn Asn Phe Gln Glu Gly His Lys Ile Leu Ser Arg Lys 
            420                 425                 430         


Ile Gln Lys Phe Glu Asn Gln Tyr Arg Gly Arg Glu Leu Pro Gly Phe 
        435                 440                 445             


Val Asn Tyr Arg Thr Phe Glu Thr Ile Val Lys Gln Gln Ile Lys Ala 
    450                 455                 460                 


Leu Glu Glu Pro Ala Val Asp Met Leu His Thr Val Thr Asp Met Val 
465                 470                 475                 480 


Arg Leu Ala Phe Thr Asp Val Ser Ile Lys Asn Phe Glu Glu Phe Phe 
                485                 490                 495     


Asn Leu His Arg Thr Ala Lys Ser Lys Ile Glu Asp Ile Arg Ala Glu 
            500                 505                 510         


Gln Glu Arg Glu Gly Glu Lys Leu Ile Arg Leu His Phe Gln Met Glu 
        515                 520                 525             


Gln Ile Val Tyr Cys Gln Asp Gln Val Tyr Arg Gly Ala Leu Gln Lys 
    530                 535                 540                 


Val Arg Glu Lys Glu Leu Glu Glu Glu Lys Lys Lys Lys Ser Trp Asp 
545                 550                 555                 560 


Phe Gly Ala Phe Gln Ser Ser Ser Ala Thr Asp Ser Ser Met Glu Glu 
                565                 570                 575     


Ile Phe Gln His Leu Met Ala Tyr His Gln Glu Ala Ser Lys Arg Ile 
            580                 585                 590         


Ser Ser His Ile Pro Leu Ile Ile Gln Phe Phe Met Leu Gln Thr Tyr 
        595                 600                 605             


Gly Gln Gln Leu Gln Lys Ala Met Leu Gln Leu Leu Gln Asp Lys Asp 
    610                 615                 620                 


Thr Tyr Ser Trp Leu Leu Lys Glu Arg Ser Asp Thr Ser Asp Lys Arg 
625                 630                 635                 640 


Lys Phe Leu Lys Glu Arg Leu Ala Arg Leu Thr Gln Ala Arg Arg Arg 
                645                 650                 655     


Leu Ala Gln Phe Pro Gly 
            660         


<210>  43
<211>  5889
<212>  DNA
<213>  Homo sapiens

<400>  43
gctgccagct gagttttttt gctgctttga gtctcagttt tctttctttc ctagagtctc       60

tgaagccaca gatctcttaa gaactttctg tctccaaacc gtggctgctc gataaatcag      120

acagaacagt taatcctcaa tttaagcctg atctaacccc tagaaacaga tatagaacaa      180

tggaagtgac aacaagattg acatggaatg atgaaaatca tctgcgcaag ctgcttggaa      240

atgtttcttt gagtcttctc tataagtcta gtgttcatgg aggtagcatt gaagatatgg      300

ttgaaagatg cagccgtcag ggatgtacta taacaatggc ttacattgat tacaatatga      360

ttgtagcctt tatgcttgga aattatatta atttacatga aagttctaca gagccaaatg      420

attccctatg gttttcactt caaaagaaaa atgacaccac tgaaatagaa actttactct      480

taaatacagc accaaaaatt attgatgagc aactggtgtg tcgtttatcg aaaacggata      540

ttttcattat atgtcgagat aataaaattt atctagataa aatgataaca agaaacttga      600

aactaaggtt ttatggccac cgtcagtatt tggaatgtga agtttttcga gttgaaggaa      660

ttaaggataa cctagacgac ataaagagga taattaaagc cagagagcac agaaataggc      720

ttctagcaga catcagagac tataggccct atgcagactt ggtttcagaa attcgtattc      780

ttttggtggg tccagttggg tctggaaagt ccagtttttt caattcagtc aagtctattt      840

ttcatggcca tgtgactggc caagccgtag tggggtctga tatcaccagc ataaccgagc      900

ggtataggat atattctgtt aaagatggaa aaaatggaaa atctctgcca tttatgttgt      960

gtgacactat ggggctagat ggggcagaag gagcaggact gtgcatggat gacattcccc     1020

acatcttaaa aggttgtatg ccagacagat atcagtttaa ttcccgtaaa ccaattacac     1080

ctgagcattc tacttttatc acctctccat ctctgaagga caggattcac tgtgtggctt     1140

atgtcttaga catcaactct attgacaatc tctactctaa aatgttggca aaagtgaagc     1200

aagttcacaa agaagtatta aactgtggta tagcatatgt ggccttgctt actaaagtgg     1260

atgattgcag tgaggttctt caagacaact ttttaaacat gagtagatct atgacttctc     1320

aaagccgggt catgaatgtc cataaaatgc taggcattcc tatttccaat attttgatgg     1380

ttggaaacta tgcttcagat ttggaactgg accccatgaa ggatattctc atcctctctg     1440

cactgaggca gatgctgcgg gctgcagatg attttttaga agatttgcct cttgaggaaa     1500

ctggtgcaat tgagagagcg ttacagccct gcatttgaga taagttgcct tgattctgac     1560

atttggccca gcctgtactg gtgtgccgca atgagagtca atctctattg acagcctgct     1620

tcagattttg cttttgttcg ttttgccttc tgtccttgga acagtcatat ctcaagttca     1680

aaggccaaaa cctgagaagc ggtgggctaa gataggtcct actgcaaacc acccctccat     1740

atttccgtac catttacaat tcagtttctg tgacatcttt ttaaaccact ggaggaaaaa     1800

tgagatattc tctaatttat tcttctataa cactctatat agagctatgt gagtactaat     1860

cacattgaat aatagttata aaattattgt atagacatct gcttcttaaa cagattgtga     1920

gttctttgag aaacagcgtg gattttactt atctgtgtat tcacagagct tagcacagtg     1980

cctggtaatg agcaagcata cttgccatta cttttccttc ccactctctc caacatcaca     2040

ttcactttaa atttttctgt atatagaaag gaaaactagc ctgggcaaca tgatgaaacc     2100

ccatctccac tgcaaaaaaa aaaaaaaaaa ataagaaaga acaaaacaaa ccccacaaaa     2160

attagctggg tatgatggca cgtgcctgta gtcccagtta ctcaggatga ttgattgagc     2220

cttggaggtg gaggctacag tgagctgaga ttgtgccact gtactctagc cagggagaaa     2280

gagtgagatc ctggctcaaa aaaaccaaat aaaacaaaac aaacaaacga aaaacagaaa     2340

ggaagactga aagagaatga aaagctgggg agaggaaata aaaataaaga aggaagagtg     2400

tttcatttat atctgaatga aaatatgaat gactctaagt aattgaatta attaaaatga     2460

gccaactttt ttttaacaat ttacatttta tttctatggg aaaaaataaa tattcctctt     2520

ctaacaaacc catgcttgat tttcattaat tgaattccaa atcatcctag ccatgtgtcc     2580

ttccatttag gttactgggg caaatcagta agaaagttct tatatttatg ctccaaataa     2640

ttctgaagtc ctcttactag ctgtgaaagc tagtactatt aagaaagaaa acaaaattcc     2700

caaaagatag ctttcacttt tttttttcct taaagacttc ctaattctct tctccaaatt     2760

cttagtcttc ttcaaaataa tatgctttgg ttcaatagtt atccacattc tgacagtcta     2820

atttagtttt aatcagaatt atactcatct tttgggtagt catagatatt aagaaagcaa     2880

gagtttctta tgtccagtta tggaatattt cctaaagcaa ggctgcaggt gaagttgtgc     2940

tcaagtgaat gttcaggaga cacaattcag tggaagaaat taagtcttta aaaaagacct     3000

aggaatagga gaaccatgga aattgaggag gtaggcctac aagtagatat tgggaacaaa     3060

attagagagg caaccagaaa aagttatttt aggctcacca gagttgttct tattgcacag     3120

taacacacca atataccaaa acagcaggta ttgcagtaga gaaagagttt aataattgaa     3180

tggcagaaaa atgaggaagg ttgaggaaac ctcaaatcta cctccctgct gagtctaagt     3240

ttaggatttt taagagaaag gcaggtaagg tgctgaaggt ctggagctgc tgatttgttg     3300

gggtataggg aatgaaatga aacatacaga gatgaaaact ggaagttttt ttttgtttgt     3360

tttgtttttt ttttgttgtt gttttttttt ttttttgttt ttttgctgag tcaattcctt     3420

ggagggggtc ttcagactga ctggtgtcag cagacccatg ggattccaag atctggaaaa     3480

ctttttagat agaaacttga tgtttcttaa cgttacatat attatcttat agaaataact     3540

aagggaagtt agtgccttgt gaccacatct atgtgacttt taggcagtaa gaaactataa     3600

ggaaaggagc taacagtcat gctgtaagta gctacaggga attggcttaa agggcaagtt     3660

ggttagtact tagctgtgtt tttattcaaa gtctacattt tatgtagtgg ttaatgtttg     3720

ctgttcatta ggatggtttc acagttacca tacaaatgta gaagcaacag gtccaaaaag     3780

tagggcatga ttttctccat gtaatccagg gagaaaacaa gccatgacca ttgttggttg     3840

ggagactgaa ggtgattgaa ggttcaccat catcctcacc aacttttggg ccataattca     3900

cccaaccctt tggtggagcc tgaaaaaaat ctgggcagaa tgtaggactt ctttattttg     3960

tttaaagggg taacacagag tgcccttatg aaggagttgg agatcctgca aggaagagaa     4020

ggagtgaagg agagatcaag agagagaaac aatgaggaac atttcatttg acccaacatc     4080

ctttaggagc ataaatgttg acactaagtt atcccttttg tgctaaaatg gacagtattg     4140

gcaaaatgat accacaactt cttattctct ggctctatat tgctttggaa acacttaaac     4200

atcaaatgga gttaaataca tatttgaaat ttaggttagg aaatattggt gaggaggcct     4260

caaaaagggg gaaacatctt ttgtctggga ggatattttc cattttgtgg atttccctga     4320

tctttttcta ccaccctgag gggtggtggg aattatcatt ttgctacatt ttagaggtca     4380

tccaggattt ttgaaacttt acattcttta cggttaagca agatgtacag ctcagtcaaa     4440

gacactaaat tcttcttaga aaaatagtgc taaggagtat agcagatgac ctatatgtgt     4500

gttggctggg agaatatcat cttaaagtga gagtgatgtt gtggagacag ttgaaatgtc     4560

aatgctagag cctctgtggt gtgaatgggc acgttaggtt gttgcattag aaagtgactg     4620

tttctgacag aaatttgtag ctttgtgcaa actcacccac catctacctc aataaaatat     4680

agagaaaaga aaaatagagc agtttgagtt ctatgaggta tgcaggccca gagagacata     4740

agtatgttcc tttagtcttg cttcctgtgt gccacactgc ccctccacaa ccatagctgg     4800

gggcaattgt ttaaagtcat tttgttcccg actagctgcc ttgcacatta tcttcatttt     4860

cctggaattt gatacagaga gcaatttata gccaattgat agcttatgct gtttcaatgt     4920

aaattcgtgg taaataactt aggaactgcc tcttcttttt ctttgaaaac ctacttataa     4980

ctgttgctaa taagaatgtg tattgttcag gacaacttgt ctccatacag ttgggttgta     5040

accctcatgc ttggcccaaa taaactctct acttatatca gtttttccta cacttcttcc     5100

ttttaggtca acaataccaa gaggggttac tgtgctgggt aatgtgtaaa cttgtgtctt     5160

gtttagaaag ataaatttaa agactatcac attgcttttt cataaaacaa gacaggtcta     5220

caattaattt attttgacgc aaattgatag gggggccaag taagccccat atgcttaatg     5280

atcagctgat gaataatcat ctcctagcaa cataactcaa tctaatgcta aggtacccac     5340

aagatggcaa ggctgatcaa agtcgtcatg gaatcctgca accaaaagcc atgggaattt     5400

ggaagccctc aaatcccatt cctaatctga tgagtctatg gaccaatttg tggaggacag     5460

tagattaaat agatctgatt tttgccatca atgtaaggag gataaaaact tgcataccaa     5520

ttgtacaccc ttgcaaaatc tttctctgat gttggagaaa atgggccagt gagatcatgg     5580

atatagaagt acagtcaatg ttcagctgta ccctcccaca atcccacttc cttcctcaac     5640

acaattcaaa caaatagact cagactgttt caggctccag gacaggaagt gcagtgtagg     5700

caaaattgca aaaattgagg gcacaggggt ggaggtgggg gggttgaata acaagctgtg     5760

ctaaataatt acgtgtaaat atattttttc atttttaaaa attgatttct tttgcacatt     5820

ccatgacaat atatgtcaca tttttaaaat aaatgcaaag aagcatacat ccaaaaaaaa     5880

aaaaaaaaa                                                             5889


<210>  44
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Glu Val Thr Thr Arg Leu Thr Trp Asn Asp Glu Asn His Leu Arg 
1               5                   10                  15      


Lys Leu Leu Gly Asn Val Ser Leu Ser Leu Leu Tyr Lys Ser Ser Val 
            20                  25                  30          


His Gly Gly Ser Ile Glu Asp Met Val Glu Arg Cys Ser Arg Gln Gly 
        35                  40                  45              


Cys Thr Ile Thr Met Ala Tyr Ile Asp Tyr Asn Met Ile Val Ala Phe 
    50                  55                  60                  


Met Leu Gly Asn Tyr Ile Asn Leu His Glu Ser Ser Thr Glu Pro Asn 
65                  70                  75                  80  


Asp Ser Leu Trp Phe Ser Leu Gln Lys Lys Asn Asp Thr Thr Glu Ile 
                85                  90                  95      


Glu Thr Leu Leu Leu Asn Thr Ala Pro Lys Ile Ile Asp Glu Gln Leu 
            100                 105                 110         


Val Cys Arg Leu Ser Lys Thr Asp Ile Phe Ile Ile Cys Arg Asp Asn 
        115                 120                 125             


Lys Ile Tyr Leu Asp Lys Met Ile Thr Arg Asn Leu Lys Leu Arg Phe 
    130                 135                 140                 


Tyr Gly His Arg Gln Tyr Leu Glu Cys Glu Val Phe Arg Val Glu Gly 
145                 150                 155                 160 


Ile Lys Asp Asn Leu Asp Asp Ile Lys Arg Ile Ile Lys Ala Arg Glu 
                165                 170                 175     


His Arg Asn Arg Leu Leu Ala Asp Ile Arg Asp Tyr Arg Pro Tyr Ala 
            180                 185                 190         


Asp Leu Val Ser Glu Ile Arg Ile Leu Leu Val Gly Pro Val Gly Ser 
        195                 200                 205             


Gly Lys Ser Ser Phe Phe Asn Ser Val Lys Ser Ile Phe His Gly His 
    210                 215                 220                 


Val Thr Gly Gln Ala Val Val Gly Ser Asp Ile Thr Ser Ile Thr Glu 
225                 230                 235                 240 


Arg Tyr Arg Ile Tyr Ser Val Lys Asp Gly Lys Asn Gly Lys Ser Leu 
                245                 250                 255     


Pro Phe Met Leu Cys Asp Thr Met Gly Leu Asp Gly Ala Glu Gly Ala 
            260                 265                 270         


Gly Leu Cys Met Asp Asp Ile Pro His Ile Leu Lys Gly Cys Met Pro 
        275                 280                 285             


Asp Arg Tyr Gln Phe Asn Ser Arg Lys Pro Ile Thr Pro Glu His Ser 
    290                 295                 300                 


Thr Phe Ile Thr Ser Pro Ser Leu Lys Asp Arg Ile His Cys Val Ala 
305                 310                 315                 320 


Tyr Val Leu Asp Ile Asn Ser Ile Asp Asn Leu Tyr Ser Lys Met Leu 
                325                 330                 335     


Ala Lys Val Lys Gln Val His Lys Glu Val Leu Asn Cys Gly Ile Ala 
            340                 345                 350         


Tyr Val Ala Leu Leu Thr Lys Val Asp Asp Cys Ser Glu Val Leu Gln 
        355                 360                 365             


Asp Asn Phe Leu Asn Met Ser Arg Ser Met Thr Ser Gln Ser Arg Val 
    370                 375                 380                 


Met Asn Val His Lys Met Leu Gly Ile Pro Ile Ser Asn Ile Leu Met 
385                 390                 395                 400 


Val Gly Asn Tyr Ala Ser Asp Leu Glu Leu Asp Pro Met Lys Asp Ile 
                405                 410                 415     


Leu Ile Leu Ser Ala Leu Arg Gln Met Leu Arg Ala Ala Asp Asp Phe 
            420                 425                 430         


Leu Glu Asp Leu Pro Leu Glu Glu Thr Gly Ala Ile Glu Arg Ala Leu 
        435                 440                 445             


Gln Pro Cys Ile 
    450         


<210>  45
<211>  4759
<212>  DNA
<213>  Homo sapiens

<400>  45
tagttattaa agttcctatg cagctccgcc tcgcgtccgg cctcatttcc tcggaaaatc       60

cctgctttcc ccgctcgcca cgccctcctc ctacccggct ttaaagctag tgaggcacag      120

cctgcgggga acgtagctag ctgcaagcag aggccggcat gaccaccgag cagcgacgca      180

gcctgcaagc cttccaggat tatatccgga agaccctgga ccctacctac atcctgagct      240

acatggcccc ctggtttagg gaggaagagg tgcagtatat tcaggctgag aaaaacaaca      300

agggcccaat ggaggctgcc acactttttc tcaagttcct gttggagctc caggaggaag      360

gctggttccg tggctttttg gatgccctag accatgcagg ttattctgga ctttatgaag      420

ccattgaaag ttgggatttc aaaaaaattg aaaagttgga ggagtataga ttacttttaa      480

aacgtttaca accagaattt aaaaccagaa ttatcccaac cgatatcatt tctgatctgt      540

ctgaatgttt aattaatcag gaatgtgaag aaattctaca gatttgctct actaagggga      600

tgatggcagg tgcagagaaa ttggtggaat gccttctcag atcagacaag gaaaactggc      660

ccaaaacttt gaaacttgct ttggagaaag aaaggaacaa gttcagtgaa ctgtggattg      720

tagagaaagg tataaaagat gttgaaacag aagatcttga ggataagatg gaaacttctg      780

acatacagat tttctaccaa gaagatccag aatgccagaa tcttagtgag aattcatgtc      840

caccttcaga agtgtctgat acaaacttgt acagcccatt taaaccaaga aattaccaat      900

tagagcttgc tttgcctgct atgaaaggaa aaaacacaat aatatgtgct cctacaggtt      960

gtggaaaaac ctttgtttca ctgcttatat gtgaacatca tcttaaaaaa ttcccacaag     1020

gacaaaaggg gaaagttgtc ttttttgcga atcagatccc agtgtatgaa cagcagaaat     1080

ctgtattctc aaaatacttt gaaagacatg ggtatagagt tacaggcatt tctggagcaa     1140

cagctgagaa tgtcccagtg gaacagattg ttgagaacaa tgacatcatc attttaactc     1200

cacagattct tgtgaacaac cttaaaaagg gaacgattcc atcactatcc atctttactt     1260

tgatgatatt tgatgaatgc cacaacacta gtaaacaaca cccgtacaat atgatcatgt     1320

ttaattatct agatcagaaa cttggaggat cttcaggccc actgccccag gtcattgggc     1380

tgactgcctc ggttggtgtt ggggatgcca aaaacacaga tgaagccttg gattatatct     1440

gcaagctgtg tgcttctctt gatgcgtcag tgatagcaac agtcaaacac aatctggagg     1500

aactggagca agttgtttat aagccccaga agtttttcag gaaagtggaa tcacggatta     1560

gcgacaaatt taaatacatc atagctcagc tgatgaggga cacagagagt ctggcaaaga     1620

gaatctgcaa agacctcgaa aacttatctc aaattcaaaa tagggaattt ggaacacaga     1680

aatatgaaca atggattgtt acagttcaga aagcatgcat ggtgttccag atgccagaca     1740

aagatgaaga gagcaggatt tgtaaagccc tgtttttata cacttcacat ttgcggaaat     1800

ataatgatgc cctcattatc agtgagcatg cacgaatgaa agatgctctg gattacttga     1860

aagacttctt cagcaatgtc cgagcagcag gattcgatga gattgagcaa gatcttactc     1920

agagatttga agaaaagctg caggaactag aaagtgtttc cagggatccc agcaatgaga     1980

atcctaaact tgaagacctc tgcttcatct tacaagaaga gtaccactta aacccagaga     2040

caataacaat tctctttgtg aaaaccagag cacttgtgga cgctttaaaa aattggattg     2100

aaggaaatcc taaactcagt tttctaaaac ctggcatatt gactggacgt ggcaaaacaa     2160

atcagaacac aggaatgacc ctcccggcac agaagtgtat attggatgca ttcaaagcca     2220

gtggagatca caatattctg attgccacct cagttgctga tgaaggcatt gacattgcac     2280

agtgcaatct tgtcatcctt tatgagtatg tgggcaatgt catcaaaatg atccaaacca     2340

gaggcagagg aagagcaaga ggtagcaagt gcttccttct gactagtaat gctggtgtaa     2400

ttgaaaaaga acaaataaac atgtacaaag aaaaaatgat gaatgactct attttacgcc     2460

ttcagacatg ggacgaagca gtatttaggg aaaagattct gcatatacag actcatgaaa     2520

aattcatcag agatagtcaa gaaaaaccaa aacctgtacc tgataaggaa aataaaaaac     2580

tgctctgcag aaagtgcaaa gccttggcat gttacacagc tgacgtaaga gtgatagagg     2640

aatgccatta cactgtgctt ggagatgctt ttaaggaatg ctttgtgagt agaccacatc     2700

ccaagccaaa gcagttttca agttttgaaa aaagagcaaa gatattctgt gcccgacaga     2760

actgcagcca tgactgggga atccatgtga agtacaagac atttgagatt ccagttataa     2820

aaattgaaag ttttgtggtg gaggatattg caactggagt tcagacactg tactcgaagt     2880

ggaaggactt tcattttgag aagataccat ttgatccagc agaaatgtcc aaatgatatc     2940

aggtcctcaa tcttcagcta cagggaatga gtaactttga gtggagaaga aacaaacata     3000

gtgggtataa tcatggatcg cttgtacccc tgtgaaaata tattttttaa aaatatcttt     3060

agcagtttgt actatattat atatgcaaag cacaaatgag tgaatcacag cactgagtat     3120

tttgtaggcc aacagagctc atagtacttg ggaaaaatta aaaagcctca tttctagcct     3180

tctttttaga gtcaactgcc aacaaacaca cagtaatcac tctgtacaca ctgggataga     3240

tgaatgaatg gaatgttggg aatttttatc tccctttgtc tccttaacct actgtaaact     3300

ggcttttgcc cttaacaatc tactgaaatt gttcttttga aggttaccag tgactctggt     3360

tgccaaatcc actgggcact tcttaacctt ctatttgacc tctgcgcatt tggccctgtt     3420

gagcactctt cttgaagctc tccctgggct tctctctctt ctagttctat tctagtcttt     3480

ttttattgag tcctcctctt tgctgatccc ttccaagggt tcaatatata tacatgtata     3540

tactgtacat atgtatatgt aactaatata catacataca ggtatgtata tgtaatggtt     3600

atatgtactc atgttcctgg tgtagcaacg tgtggtatgg ctacacagag aacatgagaa     3660

cataaagcca tttttatgct tactactaaa agctgtccac tgtagagttg ctgtatgtag     3720

caatgtgtat ccactctaca gtggtcagct tttagtagag agcataaaaa tgataaaata     3780

cttcttgaaa acttagttta ctatacatct tgccctatta atatgttctc ttaacgtgtg     3840

ccattgttct ctttgaccat tttcctataa tgatgttgat gttcaacacc tggactgaat     3900

gtctgttctc agatcccttg gatgttacag atgaggcagt ctgactgtcc tttctacttg     3960

aaagattaga atatgtatcc aaatggcatt cacgtgtcac ttagcaaggt ttgctgatgc     4020

ttcaaagagc ttagtttgcg gtttcctgga cgtggaaaca agtatctgag ttccctggag     4080

atcaacggga tgaggtgtta cagctgcctc cctcttcatg caatctggtg agcagtggtg     4140

caggcgggga gccagagaaa cttgccagtt atataacttc tctttggctt ttcttcatct     4200

gtaaaacaag gataatactg aactgtaagg gttagtggag agtttttaat taaaagaatg     4260

tgtgaaaagt acatgacaca gtagttgctt gataatagtt actagtagta gtattcttac     4320

taagacccaa tacaaatgga ttatttaaac caagtttatg agttggtttt ttttcatttt     4380

ctatttgtat tttattaaga gtgtcttttc ttatgtgatt ttttttaatt gctatttgat     4440

atggtttggc tatatgtccc cacccaaatc tcatcttgaa ttataatccc catgtgtcaa     4500

gggagggacc tgacgggagg tgattggatc acgggggcag ttgtccccat gctgttcttg     4560

ggatagtgag ttagttctca tgagatctga tggttttata agtgtttgac aattcctcct     4620

ttacacacac tctctctctc atctgctgcc atgtaagact tgcctgcttc cccttctgcc     4680

atgattgtaa gtttcctgag gcctcctcag ccatgtggaa ctgtgaatct attaagcctc     4740

ttttctttat aaatgaaaa                                                  4759


<210>  46
<211>  925
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Thr Thr Glu Gln Arg Arg Ser Leu Gln Ala Phe Gln Asp Tyr Ile 
1               5                   10                  15      


Arg Lys Thr Leu Asp Pro Thr Tyr Ile Leu Ser Tyr Met Ala Pro Trp 
            20                  25                  30          


Phe Arg Glu Glu Glu Val Gln Tyr Ile Gln Ala Glu Lys Asn Asn Lys 
        35                  40                  45              


Gly Pro Met Glu Ala Ala Thr Leu Phe Leu Lys Phe Leu Leu Glu Leu 
    50                  55                  60                  


Gln Glu Glu Gly Trp Phe Arg Gly Phe Leu Asp Ala Leu Asp His Ala 
65                  70                  75                  80  


Gly Tyr Ser Gly Leu Tyr Glu Ala Ile Glu Ser Trp Asp Phe Lys Lys 
                85                  90                  95      


Ile Glu Lys Leu Glu Glu Tyr Arg Leu Leu Leu Lys Arg Leu Gln Pro 
            100                 105                 110         


Glu Phe Lys Thr Arg Ile Ile Pro Thr Asp Ile Ile Ser Asp Leu Ser 
        115                 120                 125             


Glu Cys Leu Ile Asn Gln Glu Cys Glu Glu Ile Leu Gln Ile Cys Ser 
    130                 135                 140                 


Thr Lys Gly Met Met Ala Gly Ala Glu Lys Leu Val Glu Cys Leu Leu 
145                 150                 155                 160 


Arg Ser Asp Lys Glu Asn Trp Pro Lys Thr Leu Lys Leu Ala Leu Glu 
                165                 170                 175     


Lys Glu Arg Asn Lys Phe Ser Glu Leu Trp Ile Val Glu Lys Gly Ile 
            180                 185                 190         


Lys Asp Val Glu Thr Glu Asp Leu Glu Asp Lys Met Glu Thr Ser Asp 
        195                 200                 205             


Ile Gln Ile Phe Tyr Gln Glu Asp Pro Glu Cys Gln Asn Leu Ser Glu 
    210                 215                 220                 


Asn Ser Cys Pro Pro Ser Glu Val Ser Asp Thr Asn Leu Tyr Ser Pro 
225                 230                 235                 240 


Phe Lys Pro Arg Asn Tyr Gln Leu Glu Leu Ala Leu Pro Ala Met Lys 
                245                 250                 255     


Gly Lys Asn Thr Ile Ile Cys Ala Pro Thr Gly Cys Gly Lys Thr Phe 
            260                 265                 270         


Val Ser Leu Leu Ile Cys Glu His His Leu Lys Lys Phe Pro Gln Gly 
        275                 280                 285             


Gln Lys Gly Lys Val Val Phe Phe Ala Asn Gln Ile Pro Val Tyr Glu 
    290                 295                 300                 


Gln Gln Lys Ser Val Phe Ser Lys Tyr Phe Glu Arg His Gly Tyr Arg 
305                 310                 315                 320 


Val Thr Gly Ile Ser Gly Ala Thr Ala Glu Asn Val Pro Val Glu Gln 
                325                 330                 335     


Ile Val Glu Asn Asn Asp Ile Ile Ile Leu Thr Pro Gln Ile Leu Val 
            340                 345                 350         


Asn Asn Leu Lys Lys Gly Thr Ile Pro Ser Leu Ser Ile Phe Thr Leu 
        355                 360                 365             


Met Ile Phe Asp Glu Cys His Asn Thr Ser Lys Gln His Pro Tyr Asn 
    370                 375                 380                 


Met Ile Met Phe Asn Tyr Leu Asp Gln Lys Leu Gly Gly Ser Ser Gly 
385                 390                 395                 400 


Pro Leu Pro Gln Val Ile Gly Leu Thr Ala Ser Val Gly Val Gly Asp 
                405                 410                 415     


Ala Lys Asn Thr Asp Glu Ala Leu Asp Tyr Ile Cys Lys Leu Cys Ala 
            420                 425                 430         


Ser Leu Asp Ala Ser Val Ile Ala Thr Val Lys His Asn Leu Glu Glu 
        435                 440                 445             


Leu Glu Gln Val Val Tyr Lys Pro Gln Lys Phe Phe Arg Lys Val Glu 
    450                 455                 460                 


Ser Arg Ile Ser Asp Lys Phe Lys Tyr Ile Ile Ala Gln Leu Met Arg 
465                 470                 475                 480 


Asp Thr Glu Ser Leu Ala Lys Arg Ile Cys Lys Asp Leu Glu Asn Leu 
                485                 490                 495     


Ser Gln Ile Gln Asn Arg Glu Phe Gly Thr Gln Lys Tyr Glu Gln Trp 
            500                 505                 510         


Ile Val Thr Val Gln Lys Ala Cys Met Val Phe Gln Met Pro Asp Lys 
        515                 520                 525             


Asp Glu Glu Ser Arg Ile Cys Lys Ala Leu Phe Leu Tyr Thr Ser His 
    530                 535                 540                 


Leu Arg Lys Tyr Asn Asp Ala Leu Ile Ile Ser Glu His Ala Arg Met 
545                 550                 555                 560 


Lys Asp Ala Leu Asp Tyr Leu Lys Asp Phe Phe Ser Asn Val Arg Ala 
                565                 570                 575     


Ala Gly Phe Asp Glu Ile Glu Gln Asp Leu Thr Gln Arg Phe Glu Glu 
            580                 585                 590         


Lys Leu Gln Glu Leu Glu Ser Val Ser Arg Asp Pro Ser Asn Glu Asn 
        595                 600                 605             


Pro Lys Leu Glu Asp Leu Cys Phe Ile Leu Gln Glu Glu Tyr His Leu 
    610                 615                 620                 


Asn Pro Glu Thr Ile Thr Ile Leu Phe Val Lys Thr Arg Ala Leu Val 
625                 630                 635                 640 


Asp Ala Leu Lys Asn Trp Ile Glu Gly Asn Pro Lys Leu Ser Phe Leu 
                645                 650                 655     


Lys Pro Gly Ile Leu Thr Gly Arg Gly Lys Thr Asn Gln Asn Thr Gly 
            660                 665                 670         


Met Thr Leu Pro Ala Gln Lys Cys Ile Leu Asp Ala Phe Lys Ala Ser 
        675                 680                 685             


Gly Asp His Asn Ile Leu Ile Ala Thr Ser Val Ala Asp Glu Gly Ile 
    690                 695                 700                 


Asp Ile Ala Gln Cys Asn Leu Val Ile Leu Tyr Glu Tyr Val Gly Asn 
705                 710                 715                 720 


Val Ile Lys Met Ile Gln Thr Arg Gly Arg Gly Arg Ala Arg Gly Ser 
                725                 730                 735     


Lys Cys Phe Leu Leu Thr Ser Asn Ala Gly Val Ile Glu Lys Glu Gln 
            740                 745                 750         


Ile Asn Met Tyr Lys Glu Lys Met Met Asn Asp Ser Ile Leu Arg Leu 
        755                 760                 765             


Gln Thr Trp Asp Glu Ala Val Phe Arg Glu Lys Ile Leu His Ile Gln 
    770                 775                 780                 


Thr His Glu Lys Phe Ile Arg Asp Ser Gln Glu Lys Pro Lys Pro Val 
785                 790                 795                 800 


Pro Asp Lys Glu Asn Lys Lys Leu Leu Cys Arg Lys Cys Lys Ala Leu 
                805                 810                 815     


Ala Cys Tyr Thr Ala Asp Val Arg Val Ile Glu Glu Cys His Tyr Thr 
            820                 825                 830         


Val Leu Gly Asp Ala Phe Lys Glu Cys Phe Val Ser Arg Pro His Pro 
        835                 840                 845             


Lys Pro Lys Gln Phe Ser Ser Phe Glu Lys Arg Ala Lys Ile Phe Cys 
    850                 855                 860                 


Ala Arg Gln Asn Cys Ser His Asp Trp Gly Ile His Val Lys Tyr Lys 
865                 870                 875                 880 


Thr Phe Glu Ile Pro Val Ile Lys Ile Glu Ser Phe Val Val Glu Asp 
                885                 890                 895     


Ile Ala Thr Gly Val Gln Thr Leu Tyr Ser Lys Trp Lys Asp Phe His 
            900                 905                 910         


Phe Glu Lys Ile Pro Phe Asp Pro Ala Glu Met Ser Lys 
        915                 920                 925 


<210>  47
<211>  863
<212>  DNA
<213>  Homo sapiens

<400>  47
caaggttcag agtcacccat ctcagcaagc ccagaagtat ctgcaatatc tacgatggcc       60

tcgccctttg ctttactgat ggtcctggtg gtgctcagct gcaagtcaag ctgctctctg      120

ggctgtgatc tccctgagac ccacagcctg gataacagga ggaccttgat gctcctggca      180

caaatgagca gaatctctcc ttcctcctgt ctgatggaca gacatgactt tggatttccc      240

caggaggagt ttgatggcaa ccagttccag aaggctccag ccatctctgt cctccatgag      300

ctgatccagc agatcttcaa cctctttacc acaaaagatt catctgctgc ttgggatgag      360

gacctcctag acaaattctg caccgaactc taccagcagc tgaatgactt ggaagcctgt      420

gtgatgcagg aggagagggt gggagaaact cccctgatga atgcggactc catcttggct      480

gtgaagaaat acttccgaag aatcactctc tatctgacag agaagaaata cagcccttgt      540

gcctgggagg ttgtcagagc agaaatcatg agatccctct ctttatcaac aaacttgcaa      600

gaaagattaa ggaggaagga ataacatctg gtccaacatg aaaacaattc ttattgactc      660

atacaccagg tcacgctttc atgaattctg tcatttcaaa gactctcacc cctgctataa      720

ctatgaccat gctgataaac tgatttatct atttaaatat ttatttaact attcataaga      780

tttaaattat ttttgttcat ataacgtcat gtgcaccttt acactgtggt tagtgtaata      840

aaacatgttc cttatattta ctc                                              863


<210>  48
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ala Ser Pro Phe Ala Leu Leu Met Val Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser Leu 
            20                  25                  30          


Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile Ser 
        35                  40                  45              


Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu Arg 
        115                 120                 125             


Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  49
<211>  1143
<212>  DNA
<213>  Homo sapiens

<400>  49
gagaacctgg agcctaaggt ttaggctcac ccatttcaac cagtctagca gcatctgcaa       60

catctacaat ggccttgacc tttgctttac tggtggccct cctggtgctc agctgcaagt      120

caagctgctc tgtgggctgt gatctgcctc aaacccacag cctgggtagc aggaggacct      180

tgatgctcct ggcacagatg aggagaatct ctcttttctc ctgcttgaag gacagacatg      240

actttggatt tccccaggag gagtttggca accagttcca aaaggctgaa accatccctg      300

tcctccatga gatgatccag cagatcttca atctcttcag cacaaaggac tcatctgctg      360

cttgggatga gaccctccta gacaaattct acactgaact ctaccagcag ctgaatgacc      420

tggaagcctg tgtgatacag ggggtggggg tgacagagac tcccctgatg aaggaggact      480

ccattctggc tgtgaggaaa tacttccaaa gaatcactct ctatctgaaa gagaagaaat      540

acagcccttg tgcctgggag gttgtcagag cagaaatcat gagatctttt tctttgtcaa      600

caaacttgca agaaagttta agaagtaagg aatgaaaact ggttcaacat ggaaatgatt      660

ttcattgatt cgtatgccag ctcacctttt tatgatctgc catttcaaag actcatgttt      720

ctgctatgac catgacacga tttaaatctt ttcaaatgtt tttaggagta ttaatcaaca      780

ttgtattcag ctcttaaggc actagtccct tacagaggac catgctgact gatccattat      840

ctatttaaat atttttaaaa tattatttat ttaactattt ataaaacaac ttatttttgt      900

tcatattatg tcatgtgcac ctttgcacag tggttaatgt aataaaatat gttctttgta      960

tttggtaaat ttattttgtg ttgttcattg aacttttgct atggaaactt ttgtacttgt     1020

ttattcttta aaatgaaatt ccaagcctaa ttgtgcaacc tgattacaga ataactggta     1080

cacttcattt atccatcaat attatattca agatataagt aaaaataaac tttctgtaaa     1140

cca                                                                   1143


<210>  50
<211>  188
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val Leu His 
65                  70                  75                  80  


Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser 
                85                  90                  95      


Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr 
            100                 105                 110         


Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val Gly Val 
        115                 120                 125             


Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val Arg Lys 
    130                 135                 140                 


Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro 
145                 150                 155                 160 


Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu 
                165                 170                 175     


Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu 
            180                 185             


<210>  51
<211>  982
<212>  DNA
<213>  Homo sapiens

<400>  51
agaaaaccta gaggccgaag ttcaaggtta tccatctcaa gtagcctagc aatatttgca       60

acatcccaat ggccctgtcc ttttctttac tgatggccgt gctggtgctc agctacaaat      120

ccatctgttc tctgggctgt gatctgcctc agacccacag cctgggtaat aggagggcct      180

tgatactcct ggcacaaatg ggaagaatct ctcatttctc ctgcctgaag gacagacatg      240

atttcggatt ccccgaggag gagtttgatg gccaccagtt ccagaaggct caagccatct      300

ctgtcctcca tgagatgatc cagcagacct tcaatctctt cagcacagag gactcatctg      360

ctgcttggga acagagcctc ctagaaaaat tttccactga actttaccag caactgaatg      420

acctggaagc atgtgtgata caggaggttg gggtggaaga gactcccctg atgaatgagg      480

actccatcct ggctgtgagg aaatacttcc aaagaatcac tctttatcta acagagaaga      540

aatacagccc ttgtgcctgg gaggttgtca gagcagaaat catgagatcc ctctcgtttt      600

caacaaactt gcaaaaaaga ttaaggagga aggattgaaa cctggttcaa catggaaatg      660

atcctgattg actaatacat tatctcacac tttcatgagt tcttccattt caaagactca      720

cttctataac caccacgagt tgaatcaaaa ttttcaaatg ttttcagcag tgtgaagaag      780

cttggtgtat acctgtgcag gcactagtcc tttacagatg acaatgctga tgtctctgtt      840

catctattta tttaaatatt tatttatttt taaaatttaa attatttttt atgtgatatc      900

atgagtacct ttacattgtg gtgaatgtaa caatatatgt tcttcatatt tagccaatat      960

attaatttcc tttttcatta aa                                               982


<210>  52
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


His Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Glu Glu 
    50                  55                  60                  


Glu Phe Asp Gly His Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  53
<211>  700
<212>  DNA
<213>  Homo sapiens

<400>  53
gcccaaggtt cagggtcact caatctcaac agcccagaag catctgcaac ctccccaatg       60

gccttgccct ttgttttact gatggccctg gtggtgctca actgcaagtc aatctgttct      120

ctgggctgtg atctgcctca gacccacagc ctgagtaaca ggaggacttt gatgataatg      180

gcacaaatgg gaagaatctc tcctttctcc tgcctgaagg acagacatga ctttggattt      240

cctcaggagg agtttgatgg caaccagttc cagaaggctc aagccatctc tgtcctccat      300

gagatgatcc agcagacctt caatctcttc agcacaaagg actcatctgc tacttgggat      360

gagacacttc tagacaaatt ctacactgaa ctttaccagc agctgaatga cctggaagcc      420

tgtatgatgc aggaggttgg agtggaagac actcctctga tgaatgtgga ctctatcctg      480

actgtgagaa aatactttca aagaatcacc ctctatctga cagagaagaa atacagccct      540

tgtgcatggg aggttgtcag agcagaaatc atgagatcct tctctttatc agcaaacttg      600

caagaaagat taaggaggaa ggaatgaaaa ctggttcaac atcgaaatga ttctcattga      660

ctagtacacc atttcacact tcttgagttc tgccgtttca                            700


<210>  54
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Leu Pro Phe Val Leu Leu Met Ala Leu Val Val Leu Asn Cys 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Ser Asn Arg Arg Thr Leu Met Ile Met Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Thr Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Met Met Gln Glu Val Gly 
        115                 120                 125             


Val Glu Asp Thr Pro Leu Met Asn Val Asp Ser Ile Leu Thr Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Ala Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  55
<211>  570
<212>  DNA
<213>  Homo sapiens

<400>  55
atggctttgc cttttgcttt actgatggcc ctggtggtgc tcagctgcaa gtcaagctgc       60

tctctggact gtgatctgcc tcagacccac agcctgggtc acaggaggac catgatgctc      120

ctggcacaaa tgaggagaat ctctcttttc tcctgtctga aggacagaca tgacttcaga      180

tttccccagg aggagtttga tggcaaccag ttccagaagg ctgaagccat ctctgtcctc      240

catgaggtga ttcagcagac cttcaacctc ttcagcacaa aggactcatc tgttgcttgg      300

gatgagaggc ttctagacaa actctatact gaactttacc agcagctgaa tgacctggaa      360

gcctgtgtga tgcaggaggt gtgggtggga gggactcccc tgatgaatga ggactccatc      420

ctggctgtga gaaaatactt ccaaagaatc actctctacc tgacagagaa aaagtacagc      480

ccttgtgcct gggaggttgt cagagcagaa atcatgagat ccttctcttc atcaagaaac      540

ttgcaagaaa ggttaaggag gaaggaataa                                       570


<210>  56
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Ala Leu Pro Phe Ala Leu Leu Met Ala Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Asp Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly His Arg Arg Thr Met Met Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Arg Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Glu Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Val Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Val Ala Trp Asp Glu Arg Leu Leu Asp Lys Leu Tyr Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Val Trp 
        115                 120                 125             


Val Gly Gly Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Ser Ser Arg Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  57
<211>  736
<212>  DNA
<213>  Homo sapiens

<400>  57
tacccacctc aggtagccta gtgatatttg caaaatccca atggcccggt ccttttcttt       60

actgatggtc gtgctggtac tcagctacaa atccatctgc tctctgggct gtgatctgcc      120

tcagacccac agcctgcgta ataggagggc cttgatactc ctggcacaaa tgggaagaat      180

ctctcctttc tcctgcttga aggacagaca tgaattcaga ttcccagagg aggagtttga      240

tggccaccag ttccagaaga ctcaagccat ctctgtcctc catgagatga tccagcagac      300

cttcaatctc ttcagcacag aggactcatc tgctgcttgg gaacagagcc tcctagaaaa      360

attttccact gaactttacc agcaactgaa tgacctggaa gcatgtgtga tacaggaggt      420

tggggtggaa gagactcccc tgatgaatga ggacttcatc ctggctgtga ggaaatactt      480

ccaaagaatc actctttatc taatggagaa gaaatacagc ccttgtgcct gggaggttgt      540

cagagcagaa atcatgagat ccttctcttt ttcaacaaac ttgaaaaaag gattaaggag      600

gaaggattga aaactggttc atcatggaaa tgattctcat tgactaatgc atcatctcac      660

actttcatga gttcttccat ttcaaagact cacttctata accaccacaa gttaatcaaa      720

atttccaaat gttttc                                                      736


<210>  58
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Arg Ser Phe Ser Leu Leu Met Val Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Arg Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Glu Phe Arg Phe Pro Glu Glu 
    50                  55                  60                  


Glu Phe Asp Gly His Gln Phe Gln Lys Thr Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Phe Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Lys Lys Gly Leu Arg Arg Lys Asp 
            180                 185                 


<210>  59
<211>  1039
<212>  DNA
<213>  Homo sapiens

<400>  59
accagctcag cagcatccac aacatctaca atggccttga ctttttattt actggtggcc       60

ctagtggtgc tcagctacaa gtcattcagc tctctgggct gtgatctgcc tcagactcac      120

agcctgggta acaggagggc cttgatactc ctggcacaaa tgcgaagaat ctctcctttc      180

tcctgcctga aggacagaca tgactttgaa ttcccccagg aggagtttga tgataaacag      240

ttccagaagg ctcaagccat ctctgtcctc catgagatga tccagcagac cttcaacctc      300

ttcagcacaa aggactcatc tgctgctttg gatgagaccc ttctagatga attctacatc      360

gaacttgacc agcagctgaa tgacctggag tcctgtgtga tgcaggaagt gggggtgata      420

gagtctcccc tgatgtacga ggactccatc ctggctgtga ggaaatactt ccaaagaatc      480

actctatatc tgacagagaa gaaatacagc tcttgtgcct gggaggttgt cagagcagaa      540

atcatgagat ccttctcttt atcaatcaac ttgcaaaaaa gattgaagag taaggaatga      600

gacctggtac aacacggaaa tgattcttat agactaatac agcagctcac acttcgacaa      660

gttgtgctct ttcaaagacc cttgtttctg ccaaaaccat gctatgaatt gaatcaaatg      720

tgtcaagtgt tttcaggagt gttaagcaac atcctgttca gctgtatggg cactagtccc      780

ttacagatga ccatgctgat ggatctattc atctatttat ttaaatcttt atttagttaa      840

ctatctatag ggcttaaatt agttttgttc atattatatt atgtgaactt ttacattgtg      900

aattgtgtaa caaaaacatg ttctttatat ttattatttt gccttgttta ttaaattttt      960

actatagaaa aattctttat ttattcttta aaattgaact ccaaccctga ttgtgcaaac     1020

tgattaaaga atggatggt                                                  1039


<210>  60
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ala Leu Thr Phe Tyr Leu Leu Val Ala Leu Val Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Phe Ser Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Glu Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Asp Lys Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Leu Asp Glu Thr Leu Leu Asp Glu Phe Tyr Ile Glu Leu 
            100                 105                 110         


Asp Gln Gln Leu Asn Asp Leu Glu Ser Cys Val Met Gln Glu Val Gly 
        115                 120                 125             


Val Ile Glu Ser Pro Leu Met Tyr Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Ser Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Ile Asn Leu Gln Lys Arg Leu Lys Ser Lys Glu 
            180                 185                 


<210>  61
<211>  963
<212>  DNA
<213>  Homo sapiens

<400>  61
caaggttatc catctcaagt agcctagcaa tatttgcaac atcccaatgg ccctgtcctt       60

ttctttactt atggccgtgc tggtgctcag ctacaaatcc atctgttctc tgggctgtga      120

tctgcctcag acccacagcc tcggtaatag gagggccttg atactcctgg gacaaatggg      180

aagaatctct cctttctcct gcctgaagga cagacatgat ttccgaatcc cccaggagga      240

gtttgatggc aaccagttcc agaaggctca agccatctct gtcctccatg agatgatcca      300

gcagaccttc aatctcttca gcacagagga ctcatctgct gcttgggaac agagcctcct      360

agaaaaattt tccactgaac tttaccagca actgaatgac ctggaagcat gtgtgataca      420

ggaggttggg gtggaagaga ctcccctgat gaatgaggac tccatcctgg ctgtgaggaa      480

atacttccaa agaatcactc tttatctaat agagaggaaa tacagccctt gtgcctggga      540

ggttgtcaga gcagaaatca tgagatccct ctcgttttca acaaacttgc aaaaaagatt      600

aaggaggaag gattgaaaac tggttcaaca tggcaatgat cctgattgac taatacatta      660

tctcacactt tcatgagttc ttccatttca aagactcact tctataacca cgacgcgttg      720

aatcaaaatt ttcaaatgtt ttcagcagtg taaagaagtg tcgtgtatac ctgtgcaggc      780

actagtcctt tacagatgac cattctgatg tctctgttca tcttttgttt aaatatttat      840

ttaattattt ttaaaattta tgtaatatca tgagtcgctt tacattgtgg ttaatgtaac      900

aatatatgtt cttcatattt agccaatata ttaatttcct ttttcattaa atttttacta      960

tac                                                                    963


<210>  62
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Gly Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Arg Ile Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Ile Glu Arg Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  63
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  63
agagaaccta gagcccaagg ttcagagtca cccatctcag caagcccaga agcatctgca       60

atatctatga tggcctcgcc ctttgcttta ctgatggccc tggtggtgct cagctgcaag      120

tcaagctgct ctctgggctg tgatctccct gagacccaca gcctggataa caggaggacc      180

ttgatgctcc tggcacaaat gagcagaatc tctccttcct cctgtctgat ggacagacat      240

gactttggat ttccccagga ggagtttgat ggcaaccagt tccagaaggc tccagccatc      300

tctgtcctcc atgagctgat ccagcagatc ttcaacctct ttaccacaaa agattcatct      360

gctgcttggg atgaggacct cctagacaaa ttctgcaccg aactctacca gcagctgaat      420

gacttggaag cctgtgtgat gcaggaggag agggtgggag aaactcccct gatgaatgcg      480

gactccatct tggctgtgaa gaaatacttc cgaagaatca ctctctatct gacagagaag      540

aaatacagcc cttgtgcctg ggaggttgtc agagcagaaa tcatgagatc cctctcttta      600

tcaacaaact tgcaagaaag attaaggagg aaggaataac acctggtcca acatgaaaca      660

attcttattg actcatatac caggtcacgc tttcatgaat tctgc                      705


<210>  64
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Met Ala Ser Pro Phe Ala Leu Leu Met Ala Leu Val Val Leu Ser 
1               5                   10                  15      


Cys Lys Ser Ser Cys Ser Leu Gly Cys Asp Leu Pro Glu Thr His Ser 
            20                  25                  30          


Leu Asp Asn Arg Arg Thr Leu Met Leu Leu Ala Gln Met Ser Arg Ile 
        35                  40                  45              


Ser Pro Ser Ser Cys Leu Met Asp Arg His Asp Phe Gly Phe Pro Gln 
    50                  55                  60                  


Glu Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Pro Ala Ile Ser Val 
65                  70                  75                  80  


Leu His Glu Leu Ile Gln Gln Ile Phe Asn Leu Phe Thr Thr Lys Asp 
                85                  90                  95      


Ser Ser Ala Ala Trp Asp Glu Asp Leu Leu Asp Lys Phe Cys Thr Glu 
            100                 105                 110         


Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Met Gln Glu Glu 
        115                 120                 125             


Arg Val Gly Glu Thr Pro Leu Met Asn Ala Asp Ser Ile Leu Ala Val 
    130                 135                 140                 


Lys Lys Tyr Phe Arg Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr 
145                 150                 155                 160 


Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu 
                165                 170                 175     


Ser Leu Ser Thr Asn Leu Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 190 


<210>  65
<211>  778
<212>  DNA
<213>  Homo sapiens

<400>  65
gttacccctc atcaaccagc ccagcagcat cttcgggatt cccaatggca ttgccctttg       60

ctttaatgat ggccctggtg gtgctcagct gcaagtcaag ctgctctctg ggctgtaatc      120

tgtctcaaac ccacagcctg aataacagga ggactttgat gctcatggca caaatgagga      180

gaatctctcc tttctcctgc ctgaaggaca gacatgactt tgaatttccc caggaggaat      240

ttgatggcaa ccagttccag aaagctcaag ccatctctgt cctccatgag atgatgcagc      300

agaccttcaa tctcttcagc acaaagaact catctgctgc ttgggatgag accctcctag      360

aaaaattcta cattgaactt ttccagcaaa tgaatgacct ggaagcctgt gtgatacagg      420

aggttggggt ggaagagact cccctgatga atgaggactc catcctggct gtgaagaaat      480

acttccaaag aatcactctt tatctgatgg agaagaaata cagcccttgt gcctgggagg      540

ttgtcagagc agaaatcatg agatccctct ctttttcaac aaacttgcaa aaaagattaa      600

ggaggaagga ttgaaaactg gttcatcatg gaaatgattc tcattgacta atacatcatc      660

tcacactttc atgagttctt ccatttcaaa gactcacttc tcctataacc accacaagtt      720

gaatcaaaat tttcaaatgt tttcaggagt gtaaagaagc atcatgtata cctgtgca        778


<210>  66
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Ala Leu Pro Phe Ala Leu Met Met Ala Leu Val Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Leu Gly Cys Asn Leu Ser Gln Thr His Ser Leu 
            20                  25                  30          


Asn Asn Arg Arg Thr Leu Met Leu Met Ala Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Glu Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Met Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asn Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Thr Leu Leu Glu Lys Phe Tyr Ile Glu Leu 
            100                 105                 110         


Phe Gln Gln Met Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Arg Leu Arg Arg Lys Asp 
            180                 185                 


<210>  67
<211>  939
<212>  DNA
<213>  Homo sapiens

<400>  67
atcccaatgg ccctgtcctt ttctttactg atggccgtgc tggtgctcag ctacaaatcc       60

atctgttctc tgggctgtga tctgcctcag actcacagcc tgggtaatag gagggccttg      120

atactcctgg cacaaatggg aagaatctct catttctcct gcctgaagga cagatatgat      180

ttcggattcc cccaggaggt gtttgatggc aaccagttcc agaaggctca agccatctct      240

gccttccatg agatgatcca gcagaccttc aatctcttca gcacaaagga ttcatctgct      300

gcttgggatg agaccctcct agacaaattc tacattgaac ttttccagca actgaatgac      360

ctagaagcct gtgtgacaca ggaggttggg gtggaagaga ttgccctgat gaatgaggac      420

tccatcctgg ctgtgaggaa atactttcaa agaatcactc tttatctgat ggggaagaaa      480

tacagccctt gtgcctggga ggttgtcaga gcagaaatca tgagatcctt ctctttttca      540

acaaacttgc aaaaaggatt aagaaggaag gattgaaaac tcattcaaca tggaaatgat      600

cctcattgat taatacatca tctcacactt tcatgagttc ttccatttca aagactcact      660

tctataacca ccacaagttg aatcaaaatt tcaaaatgtt ttcaggagtg taaagaagca      720

tcgtgtttac ctgtgcaggc actagtcctt tacagatgac catgctgatg tctctattca      780

tctatttatt taaatattta tttatttaac tatttttaag gtttaaatca tgttttatgt      840

aatatcatgt gtacctttac attttgctta atgtaacaat atatgttctt catatttagt      900

taatatatta acttcctttt cattaaattt ttactatac                             939


<210>  68
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


His Phe Ser Cys Leu Lys Asp Arg Tyr Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Val Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Ala Phe 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Ile Glu Leu 
            100                 105                 110         


Phe Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Thr Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Ile Ala Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Met Gly Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Gly Leu Arg Arg Lys Asp 
            180                 185                 


<210>  69
<211>  980
<212>  DNA
<213>  Homo sapiens

<400>  69
gttcaaggtt acccatctca agtagcctag caacatttgc aacatcccaa tggccctgtc       60

cttttcttta ctgatggccg tgctggtgct cagctacaaa tccatctgtt ctctaggctg      120

tgatctgcct cagacccaca gcctgggtaa taggagggcc ttgatactcc tggcacaaat      180

gggaagaatc tctcctttct cctgcctgaa ggacagacat gactttggac ttccccagga      240

ggagtttgat ggcaaccagt tccagaagac tcaagccatc tctgtcctcc atgagatgat      300

ccagcagacc ttcaatctct tcagcacaga ggactcatct gctgcttggg aacagagcct      360

cctagaaaaa ttttccactg aactttacca gcaactgaat aacctggaag catgtgtgat      420

acaggaggtt gggatggaag agactcccct gatgaatgag gactccatcc tggctgtgag      480

gaaatacttc caaagaatca ctctttatct aacagagaag aaatacagcc cttgtgcctg      540

ggaggttgtc agagcagaaa tcatgagatc tctctctttt tcaacaaact tgcaaaaaat      600

attaaggagg aaggattgaa aactggttca acatggcaat gatcctgatt gactaataca      660

ttatctcaca ctttcatgag ttcctccatt tcaaagactc acttctataa ccaccacgag      720

ttgaatcaaa attttcaaat gttttcagca gtgtaaagaa gcgtcgtgta tacctgtgca      780

ggcactagta ctttacagat gaccatgctg atgtctctgt tcatctattt atttaaatat      840

ttatttaatt atttttaaga tttaaattat ttttttatgt aatatcatgt gtacctttac      900

attgtggtga atgtaacaat atatgttctt catatttagc caatatatta atttcctttt      960

tcattaaatt tttactatac                                                  980


<210>  70
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Leu Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Thr Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Glu Asp Ser 
                85                  90                  95      


Ser Ala Ala Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Tyr Gln Gln Leu Asn Asn Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Met Glu Glu Thr Pro Leu Met Asn Glu Asp Ser Ile Leu Ala Val Arg 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Leu Ser 
                165                 170                 175     


Phe Ser Thr Asn Leu Gln Lys Ile Leu Arg Arg Lys Asp 
            180                 185                 


<210>  71
<211>  1024
<212>  DNA
<213>  Homo sapiens

<400>  71
ttcaaggtta cccatctcaa gtagcctagc aatattggca acatcccaat ggccctgtcc       60

ttttctttac tgatggccgt gctggtgctc agctacaaat ccatctgttc tctgggctgt      120

gatctgcctc agacccacag cctgggtaat aggagggcct tgatactcct ggcacaaatg      180

ggaagaatct ctcctttctc ctgcctgaag gacagacatg actttggatt cccccaggag      240

gagtttgatg gcaaccagtt ccagaaggct caagccatct ctgtcctcca tgagatgatc      300

cagcagacct tcaatctctt cagcacaaag gactcatctg ctacttggga acagagcctc      360

ctagaaaaat tttccactga acttaaccag cagctgaatg acctggaagc ctgcgtgata      420

caggaggttg gggtggaaga gactcccctg atgaatgtgg actccatcct ggctgtgaag      480

aaatacttcc aaagaatcac tctttatctg acagagaaga aatacagccc ttgtgcctgg      540

gaggttgtca gagcagaaat catgagatcc ttctctttat caaaaatttt tcaagaaaga      600

ttaaggagga aggaatgaaa cctgtttcaa catggaaatg atctgtattg actaatacac      660

cagtccacac ttctatgact tctgccattt caaagactca tttctcctat aaccaccgca      720

tgagttgaat caaaattttc agatcttttc aggagtgtaa ggaaacatca tgtttacctg      780

tgcaggcact agtcctttac agatgaccat gctgatagat ctaattatct atctattgaa      840

atatttattt atttattaga tttaaattat ttttgtccat gtaatattat gtgtactttt      900

acattgtgtt atatcaaaat atgttattta tatttagtca atatattatt ttctttttat      960

taatttttac tattaaaact tcttatatta tttgtttatt ctttaataaa gaaataccaa     1020

gccc                                                                  1024


<210>  72
<211>  189
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Ala Leu Ser Phe Ser Leu Leu Met Ala Val Leu Val Leu Ser Tyr 
1               5                   10                  15      


Lys Ser Ile Cys Ser Leu Gly Cys Asp Leu Pro Gln Thr His Ser Leu 
            20                  25                  30          


Gly Asn Arg Arg Ala Leu Ile Leu Leu Ala Gln Met Gly Arg Ile Ser 
        35                  40                  45              


Pro Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro Gln Glu 
    50                  55                  60                  


Glu Phe Asp Gly Asn Gln Phe Gln Lys Ala Gln Ala Ile Ser Val Leu 
65                  70                  75                  80  


His Glu Met Ile Gln Gln Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser 
                85                  90                  95      


Ser Ala Thr Trp Glu Gln Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu 
            100                 105                 110         


Asn Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Glu Val Gly 
        115                 120                 125             


Val Glu Glu Thr Pro Leu Met Asn Val Asp Ser Ile Leu Ala Val Lys 
    130                 135                 140                 


Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe Ser 
                165                 170                 175     


Leu Ser Lys Ile Phe Gln Glu Arg Leu Arg Arg Lys Glu 
            180                 185                 


<210>  73
<211>  840
<212>  DNA
<213>  Homo sapiens

<400>  73
acattctaac tgcaaccttt cgaagccttt gctctggcac aacaggtagt aggcgacact       60

gttcgtgttg tcaacatgac caacaagtgt ctcctccaaa ttgctctcct gttgtgcttc      120

tccactacag ctctttccat gagctacaac ttgcttggat tcctacaaag aagcagcaat      180

tttcagtgtc agaagctcct gtggcaattg aatgggaggc ttgaatactg cctcaaggac      240

aggatgaact ttgacatccc tgaggagatt aagcagctgc agcagttcca gaaggaggac      300

gccgcattga ccatctatga gatgctccag aacatctttg ctattttcag acaagattca      360

tctagcactg gctggaatga gactattgtt gagaacctcc tggctaatgt ctatcatcag      420

ataaaccatc tgaagacagt cctggaagaa aaactggaga aagaagattt caccagggga      480

aaactcatga gcagtctgca cctgaaaaga tattatggga ggattctgca ttacctgaag      540

gccaaggagt acagtcactg tgcctggacc atagtcagag tggaaatcct aaggaacttt      600

tacttcatta acagacttac aggttacctc cgaaactgaa gatctcctag cctgtgcctc      660

tgggactgga caattgcttc aagcattctt caaccagcag atgctgttta agtgactgat      720

ggctaatgta ctgcatatga aaggacacta gaagattttg aaatttttat taaattatga      780

gttattttta tttatttaaa ttttattttg gaaaataaat tatttttggt gcaaaagtca      840


<210>  74
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Thr Asn Lys Cys Leu Leu Gln Ile Ala Leu Leu Leu Cys Phe Ser 
1               5                   10                  15      


Thr Thr Ala Leu Ser Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg 
            20                  25                  30          


Ser Ser Asn Phe Gln Cys Gln Lys Leu Leu Trp Gln Leu Asn Gly Arg 
        35                  40                  45              


Leu Glu Tyr Cys Leu Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu 
    50                  55                  60                  


Ile Lys Gln Leu Gln Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile 
65                  70                  75                  80  


Tyr Glu Met Leu Gln Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser 
                85                  90                  95      


Ser Thr Gly Trp Asn Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val 
            100                 105                 110         


Tyr His Gln Ile Asn His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu 
        115                 120                 125             


Lys Glu Asp Phe Thr Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys 
    130                 135                 140                 


Arg Tyr Tyr Gly Arg Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser 
145                 150                 155                 160 


His Cys Ala Trp Thr Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr 
                165                 170                 175     


Phe Ile Asn Arg Leu Thr Gly Tyr Leu Arg Asn 
            180                 185         


<210>  75
<211>  1514
<212>  DNA
<213>  Homo sapiens

<400>  75
gatctggtaa acctgaagca aatatagaaa cctatagggc ctgacttcct acataaagta       60

aggagggtaa aaatggaggc tagaataagg gttaaaattt tgcttctaga acagagaaaa      120

tgattttttt catatatata tgaatatata ttatatatac acatatatac atatattcac      180

tatagtgtgt atacataaat atataatata tatattgtta gtgtagtgtg tgtctgatta      240

tttacatgca tatagtatat acacttatga ctttagtacc cagacgtttt tcatttgatt      300

aagcattcat ttgtattgac acagctgaag tttactggag tttagctgaa gtctaatgca      360

aaattaatag attgttgtca tcctcttaag gtcataggga gaacacacaa atgaaaacag      420

taaaagaaac tgaaagtaca gagaaatgtt cagaaaatga aaaccatgtg tttcctatta      480

aaagccatgc atacaagcaa tgtcttcaga aaacctaggg tccaaggtta agccatatcc      540

cagctcagta aagccaggag catcctcatt tcccaatggc cctcctgttc cctctactgg      600

cagccctagt gatgaccagc tatagccctg ttggatctct gggctgtgat ctgcctcaga      660

accatggcct acttagcagg aacaccttgg tgcttctgca ccaaatgagg agaatctccc      720

ctttcttgtg tctcaaggac agaagagact tcaggttccc ccaggagatg gtaaaaggga      780

gccagttgca gaaggcccat gtcatgtctg tcctccatga gatgctgcag cagatcttca      840

gcctcttcca cacagagcgc tcctctgctg cctggaacat gaccctccta gaccaactcc      900

acactggact tcatcagcaa ctgcaacacc tggagacctg cttgctgcag gtagtgggag      960

aaggagaatc tgctggggca attagcagcc ctgcactgac cttgaggagg tacttccagg     1020

gaatccgtgt ctacctgaaa gagaagaaat acagcgactg tgcctgggaa gttgtcagaa     1080

tggaaatcat gaaatccttg ttcttatcaa caaacatgca agaaagactg agaagtaaag     1140

atagagacct gggctcatct tgaaatgatt ctcattgatt aatttgccat ataacacttg     1200

cacatgtgac tctggtcaat tcaaaagact cttatttcgg ctttaatcac agaattgact     1260

gaattagttc tgcaaatact ttgtcggtat attaagccag tatatgttaa aaagacttag     1320

gttcaggggc atcagtccct aagatgttat ttatttttac tcatttattt attcttacat     1380

tttatcatat ttatactatt tatattctta tataacaaat gtttgccttt acattgtatt     1440

aagataacaa aacatgttca gctttccatt tggttaaata ttgtattttg ttatttatta     1500

aattattttc aaac                                                       1514


<210>  76
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ala Leu Leu Phe Pro Leu Leu Ala Ala Leu Val Met Thr Ser Tyr 
1               5                   10                  15      


Ser Pro Val Gly Ser Leu Gly Cys Asp Leu Pro Gln Asn His Gly Leu 
            20                  25                  30          


Leu Ser Arg Asn Thr Leu Val Leu Leu His Gln Met Arg Arg Ile Ser 
        35                  40                  45              


Pro Phe Leu Cys Leu Lys Asp Arg Arg Asp Phe Arg Phe Pro Gln Glu 
    50                  55                  60                  


Met Val Lys Gly Ser Gln Leu Gln Lys Ala His Val Met Ser Val Leu 
65                  70                  75                  80  


His Glu Met Leu Gln Gln Ile Phe Ser Leu Phe His Thr Glu Arg Ser 
                85                  90                  95      


Ser Ala Ala Trp Asn Met Thr Leu Leu Asp Gln Leu His Thr Gly Leu 
            100                 105                 110         


His Gln Gln Leu Gln His Leu Glu Thr Cys Leu Leu Gln Val Val Gly 
        115                 120                 125             


Glu Gly Glu Ser Ala Gly Ala Ile Ser Ser Pro Ala Leu Thr Leu Arg 
    130                 135                 140                 


Arg Tyr Phe Gln Gly Ile Arg Val Tyr Leu Lys Glu Lys Lys Tyr Ser 
145                 150                 155                 160 


Asp Cys Ala Trp Glu Val Val Arg Met Glu Ile Met Lys Ser Leu Phe 
                165                 170                 175     


Leu Ser Thr Asn Met Gln Glu Arg Leu Arg Ser Lys Asp Arg Asp Leu 
            180                 185                 190         


Gly Ser Ser 
        195 


<210>  77
<211>  1240
<212>  DNA
<213>  Homo sapiens

<400>  77
cacattgttc tgatcatctg aagatcagct attagaagag aaagatcagt taagtccttt       60

ggacctgatc agcttgatac aagaactact gatttcaact tctttggctt aattctctcg      120

gaaacgatga aatatacaag ttatatcttg gcttttcagc tctgcatcgt tttgggttct      180

cttggctgtt actgccagga cccatatgta aaagaagcag aaaaccttaa gaaatatttt      240

aatgcaggtc attcagatgt agcggataat ggaactcttt tcttaggcat tttgaagaat      300

tggaaagagg agagtgacag aaaaataatg cagagccaaa ttgtctcctt ttacttcaaa      360

ctttttaaaa actttaaaga tgaccagagc atccaaaaga gtgtggagac catcaaggaa      420

gacatgaatg tcaagttttt caatagcaac aaaaagaaac gagatgactt cgaaaagctg      480

actaattatt cggtaactga cttgaatgtc caacgcaaag caatacatga actcatccaa      540

gtgatggctg aactgtcgcc agcagctaaa acagggaagc gaaaaaggag tcagatgctg      600

tttcgaggtc gaagagcatc ccagtaatgg ttgtcctgcc tgcaatattt gaattttaaa      660

tctaaatcta tttattaata tttaacatta tttatatggg gaatatattt ttagactcat      720

caatcaaata agtatttata atagcaactt ttgtgtaatg aaaatgaata tctattaata      780

tatgtattat ttataattcc tatatcctgt gactgtctca cttaatcctt tgttttctga      840

ctaattaggc aaggctatgt gattacaagg ctttatctca ggggccaact aggcagccaa      900

cctaagcaag atcccatggg ttgtgtgttt atttcacttg atgatacaat gaacacttat      960

aagtgaagtg atactatcca gttactgccg gtttgaaaat atgcctgcaa tctgagccag     1020

tgctttaatg gcatgtcaga cagaacttga atgtgtcagg tgaccctgat gaaaacatag     1080

catctcagga gatttcatgc ctggtgcttc caaatattgt tgacaactgt gactgtaccc     1140

aaatggaaag taactcattt gttaaaatta tcaatatcta atatatatga ataaagtgta     1200

agttcacaac aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                           1240


<210>  78
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Lys Tyr Thr Ser Tyr Ile Leu Ala Phe Gln Leu Cys Ile Val Leu 
1               5                   10                  15      


Gly Ser Leu Gly Cys Tyr Cys Gln Asp Pro Tyr Val Lys Glu Ala Glu 
            20                  25                  30          


Asn Leu Lys Lys Tyr Phe Asn Ala Gly His Ser Asp Val Ala Asp Asn 
        35                  40                  45              


Gly Thr Leu Phe Leu Gly Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp 
    50                  55                  60                  


Arg Lys Ile Met Gln Ser Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe 
65                  70                  75                  80  


Lys Asn Phe Lys Asp Asp Gln Ser Ile Gln Lys Ser Val Glu Thr Ile 
                85                  90                  95      


Lys Glu Asp Met Asn Val Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg 
            100                 105                 110         


Asp Asp Phe Glu Lys Leu Thr Asn Tyr Ser Val Thr Asp Leu Asn Val 
        115                 120                 125             


Gln Arg Lys Ala Ile His Glu Leu Ile Gln Val Met Ala Glu Leu Ser 
    130                 135                 140                 


Pro Ala Ala Lys Thr Gly Lys Arg Lys Arg Ser Gln Met Leu Phe Arg 
145                 150                 155                 160 


Gly Arg Arg Ala Ser Gln 
                165     


<210>  79
<211>  12979
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (5427)..(5427)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (5460)..(5461)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (12190)..(12190)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (12192)..(12192)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (12237)..(12240)
<223>  n is a, c, g, or t

<400>  79
gaattccttg agcccaggaa gctgcagtga gccacgtttg taccattgca ctccagcttg       60

ggagatagag tgagaccctg tctcaaaaaa aaaaaaaaaa aaaaaaagaa aaatttattt      120

ggcttacaga tgtctgggct gtacaagaag tgtggcagca gcatctgctt ccagtgaagg      180

cattaggctc cttctactca gcagaagaca acatgcagct ggcatgtgca gagaccacat      240

ggtaagagaa gaagccaatg ggggaatgca atggggggac ggggagacac acactttttt      300

tttttttttt gagatggagt ctcgctctgt cacccaggct ggagtgcagt ggcgcgatct      360

cggctcactg caagctctgc ctcccgggtt cacgccattc tcctgcctca gccgcccgag      420

tagctgggac tacaggtgcc caccaccacg ccccgctgat tttttgtatt tttagtagag      480

atggggtttc accatgttag ccaggatggt ctcgatctcc tgacctcgtg atctgcctgc      540

cttggcttcc caaagtgctg ggattacagg catgagccac catgcctgtc cctttttttt      600

tttttttttt tgagacaggg gctgtcaccc aggctggagt gcactggcgt ggtcatggct      660

cattgcacct ttcacctcag gctcaagaga ccctcctacc tcagcctcct cagtagctgg      720

gactaaggaa gtacaccacc atgcccagct aattattttt tttaagatgc aatctcactc      780

tgttgcccag gctgcactgc agtggtacaa tctcagctca ctgcaacctc cgcctcctgg      840

gttcaagcga ttctcttgct tcagcctcct gagtagctgg gattacagat gcctgccacc      900

aggcccggct aatttttgta tttttagtag atacagggtt tcgccatgtt ggccaggctg      960

gtctcgaact cctaacctaa ggtgatccgc ccatctcggc ctcccaaagt gctgggatta     1020

caggcatgag ccaccgtgcc tggcccatgc ccagctaagt taaaaaaatt tttggctggg     1080

caaggtgatt catacctgta attccaacaa tttgggaagc taaggcaggc agatcccatt     1140

tgagctcagg aattggagac catcttggac aatatggcga aatcctgtct ctacaaaata     1200

tacaaaaatt agctgggtgt ggtggcgctg tgcctgtagt cccagctact ccagaggctg     1260

aggtgggagg atggcttgag cccgggaggc agaggttgca gtgagccaaa atggtgacat     1320

tgcactccag cctgggcaac agagccagac cctgtctcaa aaaaaaaaaa aaaaagctct     1380

aaaaatagat agtggtgata gttagttaca caacattgtg aatgtactta aatgtcactg     1440

aattatacac ttaaatgttt aaatggtaaa ttctatctta tgtatatttt accacaattt     1500

aaaaatttta tctatttcta ttttaatgag agttttaaaa agcaggaatg gatattgaat     1560

ttccttaaat actctttgga gtctattaaa gatagcattt tacttcaaaa tccagccctg     1620

gtttctgtac ctagtacttc tgtcacacca gtaaatgtta ttgaatgaaa acaaacaaaa     1680

gaccataaag acatacctct tcacgttcac taggattggt gtcatttttt taaaaaaagg     1740

aaagaaaaat aaccagtatt ggcaacagtg tggatatata gaaatttttg tatattgctg     1800

gtaggaatat aaaataggga aaacggtttg gtggttcctc aaaaagttca acataaaccc     1860

aggcgcggtg gctcatgcct gtaatcctag cactttggga ggctgaggtg ggagaactgt     1920

ttgatcccag gagtttgaga ccagcctagg caatatggtg agacctcatc tctacaaaaa     1980

attagctagg catggtggcg catgcctgta gtcccagcta cctgggaggc taagacagaa     2040

agatcacttg agcctggaag ggagtttgag gctgcagtga gcccagattg cgccactgca     2100

ctccagcctg ggtgacagag tgatatcctg tctcaaaata aataaataaa taataaacaa     2160

acacagaatt accatatgac ccagcaactc tactcctgtg tatatgccca aaaaagctga     2220

aagcccaggc actgtggctt acacctgtaa tcccagcact ttaggaggcc gaggcacttg     2280

accccaggat tttgagacca gcctgggcaa catagtactt gttcaagaat caggctgggc     2340

atggtggctc acacctgtaa tcccagcact ttgggagggc aaggtgggag gatcacttga     2400

ggccaggcat tcgagaccag cctgggcaag atagcaatac ccacccccaa tctctacaaa     2460

agcaagtaat taattaggaa attagccaaa gccaggtgcg gtggctcacg cctgtagtcc     2520

cagcactttg ggaggctgag gtgggcagat tgcttgagtc cagagattcg agaccagcct     2580

aggcaacata tcaaaacccc gtctctacta aaagtaaaaa aagaaaaatt gcactttggg     2640

aggccaaggc ggggggatca cctgatgtca ggagttcaag accagcctgg ccaacatggt     2700

gaaaccccat ctctacaaaa atacaaaagt tagccgggca tgatggcagt gtctgtaatc     2760

ccagctactc aggaggctgg gtcggaagaa tcatttgaat ccaggaggcg gaggttgcag     2820

tgaaccaaga ttgtgccatt gcattccagc ctgggtgaca gagcaagcct ccgtctcaaa     2880

aaaaaaaaaa aaaagaaaaa ttagccagat gtggtggtgc atgcctgtgg tcccagctac     2940

tcaggaggct gtggtgggag gattgcttga gcccaagaca ctgaggctgc agtgagccat     3000

gatcacacca ctgcactcca gcctaggcaa ccagagtgag accctgtctc aaaaacaaac     3060

aaacaaacaa aaaccacttt aacagggtat ggtggtgcac acctctagtc ccagctactt     3120

gggaggttga ggcagccgga tcacttgacc ccaggagatc gaggctgcag tccagcctgg     3180

gcaaccgagt gagactgtct caaaaagaaa aaaaaaaaaa aaaggacata gcagcactat     3240

tcacaaatcc aaaagttaga aataactcag atgtccatca acagatgaat ggataaacga     3300

attgtggtat atacatataa tggactatta ttcagccatt aaaaggaatg aaatattgat     3360

acaggctata aactctatga acattgaaaa cattctaagt gaaaggaaat agacataaga     3420

ggtcacattt tgcaattctt tttttttttt tttttttttt tgagactgag tctcactctg     3480

ttgcccaggc tggagcgcag tggctcgatc tcagctcact gcaacctcca tctcccgaat     3540

tcaagcaatt cttctgcctc agcctcccga gtagctggga ttacatgtag gcatgcacca     3600

ccatgcctgg ctaatttttg tacttttagt agagatgggg tttcaccatg ttggtcaggc     3660

tggtcttgaa ctccagacct caggtggtcc acccgccttg gcctcccaaa gtgctaggat     3720

tacaggtgtg agccaccatg cccggccaca tgtatggtaa ttattgaatg tgtttggtat     3780

gttcgttgtg ggtgatgaaa tattttggaa ctagatagac gtgatggttg aacaacactg     3840

tggatgcact aaatgccact gaattgtaca ctttaaaatt gttaacttta tgttacatga     3900

atttcaccta aattaacaac aacaacaaaa aagaacttaa gacagcactt ggtttggcta     3960

ttacgtagtt tcgtgacaaa cagtggtcca tctcccagag aactggcccc aggttcctaa     4020

gaaggcaaaa ggagacacag gacctctctg cactattttt tttgcaactt cttatgagtc     4080

tataattatt tcaaaataaa agtctaaaag gaaaataaga acatgtgtga atgtggctgc     4140

cccatgcctc ccaccctcag gtctgacact cagagactga tcacctcttg agagtcctgg     4200

aactcatccc aggttttaga ccctgaatgg cctgtctggg gctggcgtct ggaggcagga     4260

tcaggagcca gctcagagca tagtttaact ttcacttttc ttttctccag aggagccagg     4320

aagagagctg tgaccagcag cgtcccttat tcgcttggcc ttggttcctg tttgcactgg     4380

ctacagcagg gcactggccc ctactgtcac cgccacctac acaaagaccc tatctctgag     4440

cgctgcagcc tactgttcag ccccaggttt gaggatggat gccctggacg cttcgaagct     4500

actggatgag gagctgtatt caagacagct gtgaggcccg aggtgggggg tggagagtgg     4560

gatggtcttc agaccttgat ctacaactgc ttgccttctg cttcccatcc acaggtatgt     4620

gctgggctca cctgccatgc agaggattca gggagccagg gtcctggtgt caggcctgca     4680

gggcctgggg gccgaggtgg ccaagaactt ggttctgatg ggtgtgggca gcctcactct     4740

gcatgatccc caccccacct gctggtccga cctggctgcc caggtaagtg tcctggggct     4800

atgggctgcc agaccaagtg gggcacggcc caagaggagt gtctttgctc aggctgcact     4860

ggctctctcc ctagtttctc ctctcagagc aggacttgga aaggagcaga gccgaggcct     4920

ctcaagagct cttggctcag ctcaacagag ctgtccaggt cgtcgtgcac acgggtgaca     4980

tcactgagga cctgctgttg gacttccagg tcagctcagg cctgcagccc tcaagagcag     5040

gaagggctgg gcaatggttt tggccctgct gatcactgtg tccacccagg tggtggtgct     5100

gactgctgca aagctggagg agcagctgaa ggtgggcacc ttgtgtcata agcatggagt     5160

ttgctttctg gcggctgaca cccggggcct cgtggggtga gtaagactgc ctgcccagcc     5220

taccatatta cagccagcaa ctggcctcat gctgtcctca gctccaggct tgctccagtg     5280

cccctccaac cagcctcagg tctatcccag catgcctttc tgattctggt ccccagtcct     5340

gccctctggt tcctccaacc tagcctccag acctgctcca gtaaccctct caaattctag     5400

ttcccaagcc tctccttgca ttccttnccc aattctggcc ctctggccct gccctagtan     5460

nccctatcct taagtacaat ctgtaagcca cctcagtgac ccctaccacc ccatctcagg     5520

cagttgttct gtgactttgg tgaggacttc actgtgcagg accccacaga ggcagaaccc     5580

ctgacagctg ccatccagca catctcccag gtgggtgctg agctgtaggc attcacccgc     5640

tgaccaagga gaggctgcca gggcctgtgg aaggcaggtc caggcaaccc tgagccaagc     5700

ctcctcctac ccagggctcc cctggcattc tcactctgag gaaaggggcc aatacccact     5760

acttccgtga tggagacttg gtgactttct cgggaattga gggaatggtt gagctcaacg     5820

actgtgatcc ccggtctatc cacgtgcggg gtaagccaat cccattccaa ttccaggtgc     5880

agggcccaag cctccactgg aagtgagcac agcctggccc ttgggatggg tttttctccc     5940

tccaccttct acaaggtgca gcaaggtttg ggacacagat gcaagatagg atggggtgtg     6000

ggaactactc aggctcaagg atcattactg actagactgg aactccctca gaggatgggt     6060

ccctggagat tggagacaca acaactttct ctcggtactt gcgtggtggg gctatcactg     6120

aagtcaagag acccaagact gtgagacatg tgagtgcaag tccatctgag gtaggggagc     6180

ttggtcgcct tgaggggccc atagcattct ggactagacc ctgagccagg tgcccttgca     6240

gaagtccctg gacacagccc tgctccagcc ccatgtggtg gcccagagct cccaggaagt     6300

tcaccatgcc cactgcctgc atcaggcctt ctgtgcactg cacaagttcc agcacctcca     6360

tggccggcca ccccagccct gggatcctgt gagtagtcct gttgctccca cccccagcct     6420

ctgtcattta ttggggtccc acctgccaga ggcaacaatg accattcaca aatccaagtc     6480

tgatctccca acactgcagc ctttagagta gagactggtt ccatggaagt gccaggcaca     6540

catcctgggg actcctgcta caccccgacc cctcagatct gtgctggaag ctgcactcag     6600

attagtgaag cctcctggac tgctgtctgg tactgggcat cctctggtgg tgctgtgcag     6660

gctggcagca gggccaggcc ttcccaccca ggcttctgct tcctcttctg tggaacaggg     6720

tggatggagg gtggctggaa ggatttgagt caggagtaga gctcaggctg gggctactat     6780

gcccacagag tcctaccaac aggttgatgc agagactgtg gtgggcctgg cccgggacct     6840

ggaaccactg aagcggacag aggaagagcc actggaagag ccactggatg aggccctagt     6900

gcggacagtc gccctaagca gtgcaaggtg tcttgagcct atggtggcat gctgggtcag     6960

tagctgccca ggaagtgctg aaggtgggca gaggcatagg tgtggggggt actgggaaga     7020

tgtggagatc agtgtgtgtg tcagagggca cccagcgcta gagagcagcc ctggagcctt     7080

caccaacctg ggtgaagcct ccagccagga tctgaggggg gtcaggaggt ggcaggagtg     7140

cccagcctga agtgctgccc ctaggcaatc tccagaagtt catgcctctg gaccagtggc     7200

tttactttga tgccctcgat tgtcttccgg aagatgggga gctccttccc agtcctgagg     7260

actgtgccct gagaggcagc cgctatgatg ggcaaattgc agtgtttggg gctggttttc     7320

aggagaaact gagacgccag cactacctcc tggtgagctg tggggtgaga ctgggggtgc     7380

ctttgggaga gccagcccag cccctctggc taaggctgtt cctgccaaca ggtgggcgct     7440

ggtgccattg gttgtgagct gctcaaagtc tttgccctag tgggactggg ggccgggaac     7500

agcgggggct tgactgttgt tgacatggac cacatagagc gctccaatct cagccgtcag     7560

ttcctcttca ggtcccagga cgttggtgtg agtgctgacc cctctccaca ctcctgcatc     7620

ccagaccgtc ctcccataca gcttcccacc caacatcttc ctgccttctt cccagagacc     7680

caaggcagag gtggctgcag cagctgcccg gggcctgaac ccagacttac aggtgatccc     7740

gctcacctac ccactggatc ccaccacaga gcacatctat ggggataact ttttctcccg     7800

tgtggatggt gtggctgctg ccctggacag tttccaggcc cgtgagtgct tgacttcgga     7860

ggtcagtccc ttgcccacag ctgtgccagt cccacttctg acccactgct cccctgccag     7920

ggcgctatgt ggctgctcgt tgcacccact atctgaagcc actgctggag gcaggcacat     7980

cgggcacctg gggcagtgct acagtattca tgccacatgt gactgaggcc tacagagccc     8040

ctgcctcagc tgcagcttct gaggatgccc cctaccctgt ctgtaccgtg cggtacttcc     8100

ctagcacagc cgagcacacc ctgcaggtag gaagcaccct ggagactccc accccaccca     8160

gctcagccct cagctgcaga cctgttctcc acctgatacc tcattcttcc tccctcctcc     8220

acagtgggcc cggcatgagt ttgaagaact cttccgactg tctgcagaga ccatcaacca     8280

ccaccaacag taaggccacc aacagaggca gatgggagtc cagggctcca agcatgagtc     8340

tgcaggactc agtctcacac ttcctcctct ctctgcaggg cacacacctc cctggcagac     8400

atggatgagc cacagacact caccttactg aagccagtgc ttggggtcct gagagtgcgt     8460

ccacagaact ggcaagactg tgtggcgtgg gctcttggcc actggaaact ctgctttcat     8520

tatggcatca aacagctgct gaggcacttc ccacctaata aagtgtgtgg ctaggggttg     8580

ggacgctggg ggctcagggg gaccagactg agcccagcag cttctactta cctacctagg     8640

tgcttgagga tggaactccc ttctggtcag gtcccaaaca gtgtccccag cccttggagt     8700

ttgacaccaa ccaagtgagt gggattctgt agggagctcc aagatagaga tgtggcccct     8760

cagagcagag gtaggcattt ctgcattctg cagagatgca cagatgccca gagagagcca     8820

tgcttgtgca tatatgggtg tctacatgtg aggcaaaggc aggcactcaa acagatccac     8880

aaatggacag tgaccccacc catgcaccat gcctctctgt tctgctctct gctcttggtc     8940

tggctgcagg acacacacct cctctacgta ctggcagctg ccaacctgta tgcccagatg     9000

catgggctgc ctggctcaca ggactggact gcactcaggg agctgctgaa gctgctgcca     9060

cagcctgacc cccaacagat ggcccccatc tttgctagta atctagagct ggcttcggct     9120

tctgctgagt ttggtgaggc tcctggccct ggcccctcat gctgtctttc aaaggcctga     9180

acctgtcctg tcctcagcct gtgctgcaga aggaagatag ggcctagggg atctacagcc     9240

aatttgctac ctctcaggcc tcctaacctc actcctccat agtttcaggc ttatcctctg     9300

gtccctcagt aggtcttctc cctgctgcct accccacatc ccagttcttg tggcagattc     9360

ttggcaaaat aaataagtaa ataaataaag tccattggtt cctggggagt gtctagctat     9420

ggcctgcagg tgaggacagg gtcacagagg tcatgagcac acatgggtga agactggggc     9480

ttctagaggg gagattgtag cattaattaa gggggcttct tgatttgatc agggaatagt     9540

aagtgacagg cttggcaaag accaagaata ggcacagggc tccaagaaga gtgcaggaga     9600

caggggctaa ggactgcctc aacatcccct tccctgacag gccctgagca gcagaaggaa     9660

ctgaacaaag ccctggaagt ctggagtgtg ggccctcccc tgaagcctct gatgtttgag     9720

aaggtgggtg cccaagtggc agtgaggagt ggggctgggg agtttgtgga gaaaggtcag     9780

gagctaataa ggtagttttg gagccccttg gcctgaattc cacagctgca gtgttaacac     9840

tactttgact tgggccttac aggatgatga cagcaacttc catgtggact ttgtggtagc     9900

ggcagctagc ctgagatgtc agaactacgg gattccaccg gtcaaccgtg cccaggtaac     9960

cccacccctt gaggcttggg cctggaggtg gagggcaaac cctggcccta cgccttgggc    10020

ccagaccaaa tctcttgtcc ttggcagagc aagcgaattg tgggccagat tatcccagcc    10080

attgccacca ctacagcagc tgtggcaggc ctgttgggcc tggagctgta taaggtggtg    10140

agtgggccac ggcctcgtag tgcctttcgc cacagctacc tacatctggc tgaaaactac    10200

ctcatccgct atatgccttt tgccccagcc atccagacgg ttgagcccat gataccccac    10260

ccttagccct actaggcctg ggtttcccct gcacctgccc atacaggccc caatctagct    10320

gccggctctc actgaaactc agactgtgca gaagtcctga agactccctc cagccctctt    10380

cctgctatga agccaggctg ggacctgtca gacacaggaa gcagccgtca gccatcccca    10440

cccccaatcc tccaaagccc aggatctggg ggagctgcag ctttaactca ttagtggagc    10500

cagacatccc ccacagtccc ctccttcctt ggagtacccc tgagggtagg tagtggggag    10560

gggaccaggg catcagccca gaaagagtct agcttccccc tgcatggtac gggggccctg    10620

gcctacctcc tacaagctga gttaaaaggt aataggcttg ccactagagg tgtggggtct    10680

gcagccctga gtgtatttgt gtcacagttg tgagtgcaac tggggtctgg gcatccccgg    10740

agtgtgggta tggaaggagc aagtttgcac atctgtgcat cagatgggag tgcagggctc    10800

ccatcttcct gtgtcctcaa tgtgggcatg catggagatg catgtgggca cacatgtgtg    10860

tgtttcctgg gcttgtgggc atttgtgttc ctgtgactgc agcgctgtga atgcctccag    10920

ccttgtgccc aggctctgca gttggcattt ccttggggca aggatgaggg tagaaggaat    10980

gccctcatga ggggagaggg cagaggtcat gggccagcac tgggtttctg ctgagcagcc    11040

tggggtccct ctggactagc acacagagcc cctttgtgag gcaccctgcc tctaaccagc    11100

atacaggctg cctttgtcca cagagtgaag caggtgaagg agaagccccc atctcacctc    11160

tagcctagtc tcagcttgac cccagtgtgt tttctcaggg gctgataagc accccctgtc    11220

ctggtctcta gatacctgcc agccatcctt ctgtccttag ctctaggtcc cagaacccca    11280

agactcttgg aaggaaggaa gggacaggag gaggaagcct ctatgcattg tatccctgct    11340

ggggtctctg ggacagtggg gccctggtgg tcactgtgcc ctttgcccct gtgtcccaat    11400

gagtagccca aggcactggc agtacataca agattggggg acaggatgtg ccccccagct    11460

cccagccttg tctttgagga acaagcagct ttatcagagg ctgcaggggc cctgctctgg    11520

gtttcctcag gaagcaccac cgccgcatcc cccactctca caactggccc atgtgatgga    11580

tcgtctgttt ccctgtgcgg gccccatagc cccatttcct gtgctggccc cggcctggac    11640

ggggaggggg ctgagactct gggcccagat cccacctccc ccccaccccc caccccctgg    11700

ctcctgtttc ctgctagtcc agctcttccc ctaggaaagg ctgctggtaa ctgggatggg    11760

ggttgggggg aggtaagaag tctctgactc ctcctctacc tcatcccagt tccatcacct    11820

gaagtggacc tcttgggacc gtctgaaggt accagctggg cagcctgaga ggaccctgga    11880

gtcgctgctg gctcatcttc aggagcagca cgggttgagg gtgaggatcc tgctgcacgg    11940

ctcagccctg ctctatgcgg ccggatggtc acctgaaaag caggcccagc acctgcccct    12000

caggtgagcc cacttgggct ttagacaggc cccaccagtc cctggaggct ggggctaggg    12060

accacactgc cttttgtctt cccagcccca ttctgggccc ctcacacctt cccaagcatt    12120

ctttccccaa atggagccag caaacaggct ggaggtgggg tgagggccga gagctgagga    12180

ggagtcttcn anggagctcg tatttggcca gcccatggct cccacatgct gcacagnnnn    12240

ttcacagcca ctcctaagga cccatagctt cctgcctcct gcttggcctc atcagctgct    12300

cctaaaatag tttcagatgt ttcctgtctt gagcagctcc tgctcctggc ttgggctcct    12360

gacggcctgc cagcaccctc tctagtccat gccaggctgc cttctgcttg ccatggctca    12420

cctctccaat ctcccctaaa cccaccccta ccagggtgac agaactggtt cagcagctga    12480

caggccaggc acctgctcct gggcagcggg tgttggtgct agagctgagc tgtgagggtg    12540

acgacgagga cactgccttc ccacctctgc actatgagct gtgacaaggc agccaccctg    12600

tcacctagct caatggagcc ccggatccca agccctgcat tgtaagccca cagtaggcac    12660

tcaataattg cttgttaaag gaaggcattg cagagaggac ggacgataga aaacagtgca    12720

ctaatgcaca cgggtgtgac atgggcatga cagggacctt cacacagaga aaaaaagctc    12780

ttcagaagat ttgtctccct gggcagtgct cacagggctg gggctgcctc ttagtgcctc    12840

aggggtatgg agccaggaca gtctagaaaa aaggctttta ttgtcccagg ctggagggca    12900

gggtcagagg tagctgacat cattgcagat gatgggctgg cggctacgac agctcatgag    12960

agctgcaaag ctgagacat                                                 12979


<210>  80
<211>  1011
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Asp Ala Leu Asp Ala Ser Lys Leu Leu Asp Glu Glu Leu Tyr Ser 
1               5                   10                  15      


Arg Gln Leu Tyr Val Leu Gly Ser Pro Ala Met Gln Arg Ile Gln Gly 
            20                  25                  30          


Ala Arg Val Leu Val Ser Gly Leu Gln Gly Leu Gly Ala Glu Val Ala 
        35                  40                  45              


Lys Asn Leu Val Leu Met Gly Val Gly Ser Leu Thr Leu His Asp Pro 
    50                  55                  60                  


His Pro Thr Cys Trp Ser Asp Leu Ala Ala Gln Phe Leu Leu Ser Glu 
65                  70                  75                  80  


Gln Asp Leu Glu Arg Ser Arg Ala Glu Ala Ser Gln Glu Leu Leu Ala 
                85                  90                  95      


Gln Leu Asn Arg Ala Val Gln Val Val Val His Thr Gly Asp Ile Thr 
            100                 105                 110         


Glu Asp Leu Leu Leu Asp Phe Gln Val Val Val Leu Thr Ala Ala Lys 
        115                 120                 125             


Leu Glu Glu Gln Leu Lys Val Gly Thr Leu Cys His Lys His Gly Val 
    130                 135                 140                 


Cys Phe Leu Ala Ala Asp Thr Arg Gly Leu Val Gly Gln Leu Phe Cys 
145                 150                 155                 160 


Asp Phe Gly Glu Asp Phe Thr Val Gln Asp Pro Thr Glu Ala Glu Pro 
                165                 170                 175     


Leu Thr Ala Ala Ile Gln His Ile Ser Gln Gly Ser Pro Gly Ile Leu 
            180                 185                 190         


Thr Leu Arg Lys Gly Ala Asn Thr His Tyr Phe Arg Asp Gly Asp Leu 
        195                 200                 205             


Val Thr Phe Ser Gly Ile Glu Gly Met Val Glu Leu Asn Asp Cys Asp 
    210                 215                 220                 


Pro Arg Ser Ile His Val Arg Glu Asp Gly Ser Leu Glu Ile Gly Asp 
225                 230                 235                 240 


Thr Thr Thr Phe Ser Arg Tyr Leu Arg Gly Gly Ala Ile Thr Glu Val 
                245                 250                 255     


Lys Arg Pro Lys Thr Val Arg His Lys Ser Leu Asp Thr Ala Leu Leu 
            260                 265                 270         


Gln Pro His Val Val Ala Gln Ser Ser Gln Glu Val His His Ala His 
        275                 280                 285             


Cys Leu His Gln Ala Phe Cys Ala Leu His Lys Phe Gln His Leu His 
    290                 295                 300                 


Gly Arg Pro Pro Gln Pro Trp Asp Pro Val Asp Ala Glu Thr Val Val 
305                 310                 315                 320 


Gly Leu Ala Arg Asp Leu Glu Pro Leu Lys Arg Thr Glu Glu Glu Pro 
                325                 330                 335     


Leu Glu Glu Pro Leu Asp Glu Ala Leu Val Arg Thr Val Ala Leu Ser 
            340                 345                 350         


Ser Ala Arg Cys Leu Glu Pro Met Val Ala Cys Trp Val Ser Ser Cys 
        355                 360                 365             


Pro Gly Ser Ala Glu Gly Asn Leu Gln Lys Phe Met Pro Leu Asp Gln 
    370                 375                 380                 


Trp Leu Tyr Phe Asp Ala Leu Asp Cys Leu Pro Glu Asp Gly Glu Leu 
385                 390                 395                 400 


Leu Pro Ser Pro Glu Asp Cys Ala Leu Arg Gly Ser Arg Tyr Asp Gly 
                405                 410                 415     


Gln Ile Ala Val Phe Gly Ala Gly Phe Gln Glu Lys Leu Arg Arg Gln 
            420                 425                 430         


His Tyr Leu Leu Val Gly Ala Gly Ala Ile Gly Cys Glu Leu Leu Lys 
        435                 440                 445             


Val Phe Ala Leu Val Gly Leu Gly Ala Gly Asn Ser Gly Gly Leu Thr 
    450                 455                 460                 


Val Val Asp Met Asp His Ile Glu Arg Ser Asn Leu Ser Arg Gln Phe 
465                 470                 475                 480 


Leu Phe Arg Ser Gln Asp Val Gly Arg Pro Lys Ala Glu Val Ala Ala 
                485                 490                 495     


Ala Ala Ala Arg Gly Leu Asn Pro Asp Leu Gln Val Ile Pro Leu Thr 
            500                 505                 510         


Tyr Pro Leu Asp Pro Thr Thr Glu His Ile Tyr Gly Asp Asn Phe Phe 
        515                 520                 525             


Ser Arg Val Asp Gly Val Ala Ala Ala Leu Asp Ser Phe Gln Ala Arg 
    530                 535                 540                 


Arg Tyr Val Ala Ala Arg Cys Thr His Tyr Leu Lys Pro Leu Leu Glu 
545                 550                 555                 560 


Ala Gly Thr Ser Gly Thr Trp Gly Ser Ala Thr Val Phe Met Pro His 
                565                 570                 575     


Val Thr Glu Ala Tyr Arg Ala Pro Ala Ser Ala Ala Ala Ser Glu Asp 
            580                 585                 590         


Ala Pro Tyr Pro Val Cys Thr Val Arg Tyr Phe Pro Ser Thr Ala Glu 
        595                 600                 605             


His Thr Leu Gln Trp Ala Arg His Glu Phe Glu Glu Leu Phe Arg Leu 
    610                 615                 620                 


Ser Ala Glu Thr Ile Asn His His Gln Gln Ala His Thr Ser Leu Ala 
625                 630                 635                 640 


Asp Met Asp Glu Pro Gln Thr Leu Thr Leu Leu Lys Pro Val Leu Gly 
                645                 650                 655     


Val Leu Arg Val Arg Pro Gln Asn Trp Gln Asp Cys Val Ala Trp Ala 
            660                 665                 670         


Leu Gly His Trp Lys Leu Cys Phe His Tyr Gly Ile Lys Gln Leu Leu 
        675                 680                 685             


Arg His Phe Pro Pro Asn Lys Val Leu Glu Asp Gly Thr Pro Phe Trp 
    690                 695                 700                 


Ser Gly Pro Lys Gln Cys Pro Gln Pro Leu Glu Phe Asp Thr Asn Gln 
705                 710                 715                 720 


Asp Thr His Leu Leu Tyr Val Leu Ala Ala Ala Asn Leu Tyr Ala Gln 
                725                 730                 735     


Met His Gly Leu Pro Gly Ser Gln Asp Trp Thr Ala Leu Arg Glu Leu 
            740                 745                 750         


Leu Lys Leu Leu Pro Gln Pro Asp Pro Gln Gln Met Ala Pro Ile Phe 
        755                 760                 765             


Ala Ser Asn Leu Glu Leu Ala Ser Ala Ser Ala Glu Phe Gly Pro Glu 
    770                 775                 780                 


Gln Gln Lys Glu Leu Asn Lys Ala Leu Glu Val Trp Ser Val Gly Pro 
785                 790                 795                 800 


Pro Leu Lys Pro Leu Met Phe Glu Lys Asp Asp Asp Ser Asn Phe His 
                805                 810                 815     


Val Asp Phe Val Val Ala Ala Ala Ser Leu Arg Cys Gln Asn Tyr Gly 
            820                 825                 830         


Ile Pro Pro Val Asn Arg Ala Gln Ser Lys Arg Ile Val Gly Gln Ile 
        835                 840                 845             


Ile Pro Ala Ile Ala Thr Thr Thr Ala Ala Val Ala Gly Leu Leu Gly 
    850                 855                 860                 


Leu Glu Leu Tyr Lys Val Val Ser Gly Pro Arg Pro Arg Ser Ala Phe 
865                 870                 875                 880 


Arg His Ser Tyr Leu His Leu Ala Glu Asn Tyr Leu Ile Arg Tyr Met 
                885                 890                 895     


Pro Phe Ala Pro Ala Ile Gln Thr Phe His His Leu Lys Trp Thr Ser 
            900                 905                 910         


Trp Asp Arg Leu Lys Val Pro Ala Gly Gln Pro Glu Arg Thr Leu Glu 
        915                 920                 925             


Ser Leu Leu Ala His Leu Gln Glu Gln His Gly Leu Arg Val Arg Ile 
    930                 935                 940                 


Leu Leu His Gly Ser Ala Leu Leu Tyr Ala Ala Gly Trp Ser Pro Glu 
945                 950                 955                 960 


Lys Gln Ala Gln His Leu Pro Leu Arg Val Thr Glu Leu Val Gln Gln 
                965                 970                 975     


Leu Thr Gly Gln Ala Pro Ala Pro Gly Gln Arg Val Leu Val Leu Glu 
            980                 985                 990         


Leu Ser Cys Glu Gly Asp Asp Glu  Asp Thr Ala Phe Pro  Pro Leu His 
        995                 1000                 1005             


Tyr Glu  Leu 
    1010     


<210>  81
<211>  1642
<212>  DNA
<213>  Homo sapiens

<400>  81
aagccacggg gagaaacgtt gcagcccgcg ccgaacgccg ggcagcacaa aggatccccg       60

actgccgggg agcggtgctc ggagggcaca ggtctacgcc atcccccacg cagtttcgga      120

gatggagcgc tgggcccatg gagggaaggc ggcaggctcg gcggctccgg cagcttgctg      180

gggcaggggc tcaaggcggc agtccgatag tggaggccgc tgagaactgt cacggagctg      240

cgtctgtaca gcgagcatcc cttatttatt cagggcgagt gtgtatttgg ggcggcgtgc      300

agggggctga caaagaccgg agagctcccg gtgcggccgc cggcggagcg aagactggaa      360

cccgtatgag cgccccccag cgcccctgag cgctcgccgc cggtgcacgg cgcaccccgc      420

gggaggcagg gatcagcaaa gccgtgcgcc ccgaggcccg cccccgtctc cgcacaaaga      480

ccgagctgga ggatcttcag aagaagcctc ccccatacct gcggaacctg tccagcgatg      540

atgccaatgt cctggtgtgg cacgctctcc tcctacccga ccaacctccc taccacctga      600

aagccttcaa cctgcgcatc agcttcccgc cggagtatcc gttcaagcct cccatgatca      660

aattcacaac caagatctac caccccaacg tggacgagaa cggacagatt tgcctgccca      720

tcatcagcag tgagaactgg aagccttgca ccaagacttg ccaagtcctg gaggccctca      780

atgtgctggt gaatagaccg aatatcaggg agcccctgcg gatggacctc gctgacctgc      840

tgacacagaa tccggagctg ttcagaaaga atgccgaaga gttcaccctc cgattcggag      900

tggaccggcc ctcctaactc atgttctgac cctctgtgca ctggatcctc ggcatagcgg      960

acggacacac ctcatggact gaggccagag ccccctgtgg cccattcccc attcattttt     1020

cccttcttag gttgttagtc attagtttgt gtgtgtgtgt ggtggaggga agggagctat     1080

gagtgtgtgt gttgtgtatg gactcactcc caggttcacc tggccacagg tgcacccttc     1140

ccacaccctt tacattcccc agagccaagg gagtttaagt ttgcagttac aggccagttc     1200

tccagctctc catcttagag agacaggtca ccttgcaggc ctgcttgcag gaaatgaatc     1260

cagcagccaa ctcgaatccc cctagggctc aggcactgag ggcctgggga cagtggagca     1320

tatgggtggg agacagatgg agggtaccct atttacaact gagtcagcca agccactgat     1380

gggaatatac agatttaggt gctaaaccat ttattttcca cggatgagtc acaatctgaa     1440

gaatcaaact tccatcctga aaatctatat gtttcaaaac cacttgccat cctgttagat     1500

tgccagttcc tgggaccagg cctcagactg tgaagtatat atcctccagc attcagtcca     1560

gggggagcca cggaaaccat gttcttgctt aagccattaa agtcagagat gaattctgga     1620

aaaaaaaaaa aaaaaaaaaa aa                                              1642


<210>  82
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Ile Lys Phe Thr Thr Lys Ile Tyr His Pro Asn Val Asp Glu Asn 
1               5                   10                  15      


Gly Gln Ile Cys Leu Pro Ile Ile Ser Ser Glu Asn Trp Lys Pro Cys 
            20                  25                  30          


Thr Lys Thr Cys Gln Val Leu Glu Ala Leu Asn Val Leu Val Asn Arg 
        35                  40                  45              


Pro Asn Ile Arg Glu Pro Leu Arg Met Asp Leu Ala Asp Leu Leu Thr 
    50                  55                  60                  


Gln Asn Pro Glu Leu Phe Arg Lys Asn Ala Glu Glu Phe Thr Leu Arg 
65                  70                  75                  80  


Phe Gly Val Asp Arg Pro Ser 
                85          


<210>  83
<211>  1283
<212>  DNA
<213>  Homo sapiens

<400>  83
gggggtgggg tccccggggc ggggcggggc gcgctgtgtc gcgggtcgga gctcggtcct       60

gctggaggcc acgggtgcca cacactcggt cccgacatga tggcgagcat gcgagtggtg      120

aaggagctgg aggatcttca gaagaagcct cccccatacc tgcggaacct gtccagcgat      180

gatgccaatg tcctggtgtg gcacgctctc ctcctacccg accaacctcc ctaccacctg      240

aaagccttca acctgcgcat cagcttcccg ccggagtatc cgttcaagcc tcccatgatc      300

aaattcacaa ccaagatcta ccaccccaac gtggacgaga acggacagat ttgcctgccc      360

atcatcagca gtgagaactg gaagccttgc accaagactt gccaagtcct ggaggccctc      420

aatgtgctgg tgaatagacc gaatatcagg gagcccctgc ggatggacct cgctgacctg      480

ctgacacaga atccggagct gttcagaaag aatgccgaag agttcaccct ccgattcgga      540

gtggaccggc cctcctaact catgttctga ccctctgtgc actggatcct cggcatagcg      600

gacggacaca cctcatggac tgaggccaga gccccctgtg gcccattccc cattcatttt      660

tcccttctta ggttgttagt cattagtttg tgtgtgtgtg tggtggaggg aagggagcta      720

tgagtgtgtg tgttgtgtat ggactcactc ccaggttcac ctggccacag gtgcaccctt      780

cccacaccct ttacattccc cagagccaag ggagtttaag tttgcagtta caggccagtt      840

ctccagctct ccatcttaga gagacaggtc accttgcagg cctgcttgca ggaaatgaat      900

ccagcagcca actcgaatcc ccctagggct caggcactga gggcctgggg acagtggagc      960

atatgggtgg gagacagatg gagggtaccc tatttacaac tgagtcagcc aagccactga     1020

tgggaatata cagatttagg tgctaaacca tttattttcc acggatgagt cacaatctga     1080

agaatcaaac ttccatcctg aaaatctata tgtttcaaaa ccacttgcca tcctgttaga     1140

ttgccagttc ctgggaccag gcctcagact gtgaagtata tatcctccag cattcagtcc     1200

agggggagcc acggaaacca tgttcttgct taagccatta aagtcagaga tgaattctgg     1260

aaaaaaaaaa aaaaaaaaaa aaa                                             1283


<210>  84
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Met Ala Ser Met Arg Val Val Lys Glu Leu Glu Asp Leu Gln Lys 
1               5                   10                  15      


Lys Pro Pro Pro Tyr Leu Arg Asn Leu Ser Ser Asp Asp Ala Asn Val 
            20                  25                  30          


Leu Val Trp His Ala Leu Leu Leu Pro Asp Gln Pro Pro Tyr His Leu 
        35                  40                  45              


Lys Ala Phe Asn Leu Arg Ile Ser Phe Pro Pro Glu Tyr Pro Phe Lys 
    50                  55                  60                  


Pro Pro Met Ile Lys Phe Thr Thr Lys Ile Tyr His Pro Asn Val Asp 
65                  70                  75                  80  


Glu Asn Gly Gln Ile Cys Leu Pro Ile Ile Ser Ser Glu Asn Trp Lys 
                85                  90                  95      


Pro Cys Thr Lys Thr Cys Gln Val Leu Glu Ala Leu Asn Val Leu Val 
            100                 105                 110         


Asn Arg Pro Asn Ile Arg Glu Pro Leu Arg Met Asp Leu Ala Asp Leu 
        115                 120                 125             


Leu Thr Gln Asn Pro Glu Leu Phe Arg Lys Asn Ala Glu Glu Phe Thr 
    130                 135                 140                 


Leu Arg Phe Gly Val Asp Arg Pro Ser 
145                 150             


<210>  85
<211>  665
<212>  DNA
<213>  Homo sapiens

<400>  85
gggaacacat ccaagcttaa gacggtgagg tcagcttcac attctcagga actctccttc       60

tttgggtctg gctgaagttg aggatctctt actctctagg ccacggaatt aacccgagca      120

ggcatggagg cctctgctct cacctcatca gcagtgacca gtgtggccaa agtggtcagg      180

gtggcctctg gctctgccgt agttttgccc ctggccagga ttgctacagt tgtgattgga      240

ggagttgtgg ccatggcggc tgtgcccatg gtgctcagtg ccatgggctt cactgcggcg      300

ggaatcgcct cgtcctccat agcagccaag atgatgtccg cggcggccat tgccaatggg      360

ggtggagttg cctcgggcag ccttgtggct actctgcagt cactgggagc aactggactc      420

tccggattga ccaagttcat cctgggctcc attgggtctg ccattgcggc tgtcattgcg      480

aggttctact agctccctgc ccctcgccct gcagagaaga gaaccatgcc aggggagaag      540

gcacccagcc atcctgaccc agcgaggagc caactatccc aaatatacct ggggtgaaat      600

ataccaaatt ctgcatctcc agaggaaaat aagaaataaa gatgaattgt tgcaactctt      660

caaaa                                                                  665


<210>  86
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Glu Ala Ser Ala Leu Thr Ser Ser Ala Val Thr Ser Val Ala Lys 
1               5                   10                  15      


Val Val Arg Val Ala Ser Gly Ser Ala Val Val Leu Pro Leu Ala Arg 
            20                  25                  30          


Ile Ala Thr Val Val Ile Gly Gly Val Val Ala Met Ala Ala Val Pro 
        35                  40                  45              


Met Val Leu Ser Ala Met Gly Phe Thr Ala Ala Gly Ile Ala Ser Ser 
    50                  55                  60                  


Ser Ile Ala Ala Lys Met Met Ser Ala Ala Ala Ile Ala Asn Gly Gly 
65                  70                  75                  80  


Gly Val Ala Ser Gly Ser Leu Val Ala Thr Leu Gln Ser Leu Gly Ala 
                85                  90                  95      


Thr Gly Leu Ser Gly Leu Thr Lys Phe Ile Leu Gly Ser Ile Gly Ser 
            100                 105                 110         


Ala Ile Ala Ala Val Ile Ala Arg Phe Tyr 
        115                 120         


<210>  87
<211>  656
<212>  DNA
<213>  Homo sapiens

<400>  87
gggaacacat ccaagcttaa gacggtgagg tcagcttcac attctcagga actctccttc       60

tttgggtctg gctgaagttg aggatctctt actctctagg ccacggaatt aacccgagca      120

ggcatggagg cctctgctct cacctcatca gcagtgacca gtgtggccaa agtggtcagg      180

gtggcctctg gctctgccgt agttttgccc ctggccagga ttgctacagt tgtgattgga      240

ggagttgtgg ctgtgcccat ggtgctcagt gccatgggct tcactgcggc gggaatcgcc      300

tcgtcctcca tagcagccaa gatgatgtcc gcggcggcca ttgccaatgg gggtggagtt      360

gcctcgggca gccttgtggc tactctgcag tcactgggag caactggact ctccggattg      420

accaagttca tcctgggctc cattgggtct gccattgcgg ctgtcattgc gaggttctac      480

tagctccctg cccctcgccc tgcagagaag agaaccatgc caggggagaa ggcacccagc      540

catcctgacc cagcgaggag ccaactatcc caaatatacc tggggtgaaa tataccaaat      600

tctgcatctc cagaggaaaa taagaaataa agatgaattg ttgcaactct tcaaaa          656


<210>  88
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Glu Ala Ser Ala Leu Thr Ser Ser Ala Val Thr Ser Val Ala Lys 
1               5                   10                  15      


Val Val Arg Val Ala Ser Gly Ser Ala Val Val Leu Pro Leu Ala Arg 
            20                  25                  30          


Ile Ala Thr Val Val Ile Gly Gly Val Val Ala Val Pro Met Val Leu 
        35                  40                  45              


Ser Ala Met Gly Phe Thr Ala Ala Gly Ile Ala Ser Ser Ser Ile Ala 
    50                  55                  60                  


Ala Lys Met Met Ser Ala Ala Ala Ile Ala Asn Gly Gly Gly Val Ala 
65                  70                  75                  80  


Ser Gly Ser Leu Val Ala Thr Leu Gln Ser Leu Gly Ala Thr Gly Leu 
                85                  90                  95      


Ser Gly Leu Thr Lys Phe Ile Leu Gly Ser Ile Gly Ser Ala Ile Ala 
            100                 105                 110         


Ala Val Ile Ala Arg Phe Tyr 
        115                 


<210>  89
<211>  3617
<212>  DNA
<213>  Homo sapiens

<400>  89
atcgaaacag aaaccaaagt caggcaaact ctgtaagaac tgcctgacag aaagctggac       60

tcaaagctcc tacccgagtg tgcagcagga tcgccccggt ccgggacccc aggcgcacac      120

cgcagagtcc aaagtgccgc gcctgccggc cgcacctgcc tgccgcggcc ccgcgcgccg      180

ccccgctgcc cacctgcccg cctgcccacc tgcccaggtg cgagtgcagc cccgcgcgcc      240

ggcctgagag ccctgtggac aacctcgtca ttgtcaggca cagagcggta gaccctgctt      300

ctctaagtgg gcagcggaca gcggcacgca catttcacct gtcccgcaga caacagcacc      360

atctgcttgg gagaaccctc tcccttctct gagaaagaaa gatgtcgaat gggtattcca      420

cagacgagaa tttccgctat ctcatctcgt gcttcagggc cagggtgaaa atgtacatcc      480

aggtggagcc tgtgctggac tacctgacct ttctgcctgc agaggtgaag gagcagattc      540

agaggacagt cgccacctcc gggaacatgc aggcagttga actgctgctg agcaccttgg      600

agaagggagt ctggcacctt ggttggactc gggaattcgt ggaggccctc cggagaaccg      660

gcagccctct ggccgcccgc tacatgaacc ctgagctcac ggacttgccc tctccatcgt      720

ttgagaacgc tcatgatgaa tatctccaac tgctgaacct ccttcagccc actctggtgg      780

acaagcttct agttagagac gtcttggata agtgcatgga ggaggaactg ttgacaattg      840

aagacagaaa ccggattgct gctgcagaaa acaatggaaa tgaatcaggt gtaagagagc      900

tactaaaaag gattgtgcag aaagaaaact ggttctctgc atttctgaat gttcttcgtc      960

aaacaggaaa caatgaactt gtccaagagt taacaggctc tgattgctca gaaagcaatg     1020

cagagattga gaatttatca caagttgatg gtcctcaagt ggaagagcaa cttctttcaa     1080

ccacagttca gccaaatctg gagaaggagg tctggggcat ggagaataac tcatcagaat     1140

catcttttgc agattcttct gtagtttcag aatcagacac aagtttggca gaaggaagtg     1200

tcagctgctt agatgaaagt cttggacata acagcaacat gggcagtgat tcaggcacca     1260

tgggaagtga ttcagatgaa gagaatgtgg cagcaagagc atccccggag ccagaactcc     1320

agctcaggcc ttaccaaatg gaagttgccc agccagcctt ggaagggaag aatatcatca     1380

tctgcctccc tacagggagt ggaaaaacca gagtggctgt ttacattgcc aaggatcact     1440

tagacaagaa gaaaaaagca tctgagcctg gaaaagttat agttcttgtc aataaggtac     1500

tgctagttga acagctcttc cgcaaggagt tccaaccatt tttgaagaaa tggtatcgtg     1560

ttattggatt aagtggtgat acccaactga aaatatcatt tccagaagtt gtcaagtcct     1620

gtgatattat tatcagtaca gctcaaatcc ttgaaaactc cctcttaaac ttggaaaatg     1680

gagaagatgc tggtgttcaa ttgtcagact tttccctcat tatcattgat gaatgtcatc     1740

acaccaacaa agaagcagtg tataataaca tcatgaggca ttatttgatg cagaagttga     1800

aaaacaatag actcaagaaa gaaaacaaac cagtgattcc ccttcctcag atactgggac     1860

taacagcttc acctggtgtt ggaggggcca cgaagcaagc caaagctgaa gaacacattt     1920

taaaactatg tgccaatctt gatgcattta ctattaaaac tgttaaagaa aaccttgatc     1980

aactgaaaaa ccaaatacag gagccatgca agaagtttgc cattgcagat gcaaccagag     2040

aagatccatt taaagagaaa cttctagaaa taatgacaag gattcaaact tattgtcaaa     2100

tgagtccaat gtcagatttt ggaactcaac cctatgaaca atgggccatt caaatggaaa     2160

aaaaagctgc aaaagaagga aatcgcaaag aacgtgtttg tgcagaacat ttgaggaagt     2220

acaatgaggc cctacaaatt aatgacacaa ttcgaatgat agatgcgtat actcatcttg     2280

aaactttcta taatgaagag aaagataaga agtttgcagt catagaagat gatagtgatg     2340

agggtggtga tgatgagtat tgtgatggtg atgaagatga ggatgattta aagaaacctt     2400

tgaaactgga tgaaacagat agatttctca tgactttatt ttttgaaaac aataaaatgt     2460

tgaaaaggct ggctgaaaac ccagaatatg aaaatgaaaa gctgaccaaa ttaagaaata     2520

ccataatgga gcaatatact aggactgagg aatcagcacg aggaataatc tttacaaaaa     2580

cacgacagag tgcatatgcg ctttcccagt ggattactga aaatgaaaaa tttgctgaag     2640

taggagtcaa agcccaccat ctgattggag ctggacacag cagtgagttc aaacccatga     2700

cacagaatga acaaaaagaa gtcattagta aatttcgcac tggaaaaata aatctgctta     2760

tcgctaccac agtggcagaa gaaggtctgg atattaaaga atgtaacatt gttatccgtt     2820

atggtctcgt caccaatgaa atagccatgg tccaggcccg tggtcgagcc agagctgatg     2880

agagcaccta cgtcctggtt gctcacagtg gttcaggagt tatcgaacat gagacagtta     2940

atgatttccg agagaagatg atgtataaag ctatacattg tgttcaaaat atgaaaccag     3000

aggagtatgc tcataagatt ttggaattac agatgcaaag tataatggaa aagaaaatga     3060

aaaccaagag aaatattgcc aagcattaca agaataaccc atcactaata actttccttt     3120

gcaaaaactg cagtgtgcta gcctgttctg gggaagatat ccatgtaatt gagaaaatgc     3180

atcacgtcaa tatgacccca gaattcaagg aactttacat tgtaagagaa aacaaagcac     3240

tgcaaaagaa gtgtgccgac tatcaaataa atggtgaaat catctgcaaa tgtggccagg     3300

cttggggaac aatgatggtg cacaaaggct tagatttgcc ttgtctcaaa ataaggaatt     3360

ttgtagtggt tttcaaaaat aattcaacaa agaaacaata caaaaagtgg gtagaattac     3420

ctatcacatt tcccaatctt gactattcag aatgctgttt atttagtgat gaggattagc     3480

acttgattga agattctttt aaaatactat cagttaaaca tttaatatga ttatgattaa     3540

tgtattcatt atgctacaga actgacataa gaatcaataa aatgattgtt ttactctgca     3600

aaaaaaaaaa aaaaaaa                                                    3617


<210>  90
<211>  1025
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ser Asn Gly Tyr Ser Thr Asp Glu Asn Phe Arg Tyr Leu Ile Ser 
1               5                   10                  15      


Cys Phe Arg Ala Arg Val Lys Met Tyr Ile Gln Val Glu Pro Val Leu 
            20                  25                  30          


Asp Tyr Leu Thr Phe Leu Pro Ala Glu Val Lys Glu Gln Ile Gln Arg 
        35                  40                  45              


Thr Val Ala Thr Ser Gly Asn Met Gln Ala Val Glu Leu Leu Leu Ser 
    50                  55                  60                  


Thr Leu Glu Lys Gly Val Trp His Leu Gly Trp Thr Arg Glu Phe Val 
65                  70                  75                  80  


Glu Ala Leu Arg Arg Thr Gly Ser Pro Leu Ala Ala Arg Tyr Met Asn 
                85                  90                  95      


Pro Glu Leu Thr Asp Leu Pro Ser Pro Ser Phe Glu Asn Ala His Asp 
            100                 105                 110         


Glu Tyr Leu Gln Leu Leu Asn Leu Leu Gln Pro Thr Leu Val Asp Lys 
        115                 120                 125             


Leu Leu Val Arg Asp Val Leu Asp Lys Cys Met Glu Glu Glu Leu Leu 
    130                 135                 140                 


Thr Ile Glu Asp Arg Asn Arg Ile Ala Ala Ala Glu Asn Asn Gly Asn 
145                 150                 155                 160 


Glu Ser Gly Val Arg Glu Leu Leu Lys Arg Ile Val Gln Lys Glu Asn 
                165                 170                 175     


Trp Phe Ser Ala Phe Leu Asn Val Leu Arg Gln Thr Gly Asn Asn Glu 
            180                 185                 190         


Leu Val Gln Glu Leu Thr Gly Ser Asp Cys Ser Glu Ser Asn Ala Glu 
        195                 200                 205             


Ile Glu Asn Leu Ser Gln Val Asp Gly Pro Gln Val Glu Glu Gln Leu 
    210                 215                 220                 


Leu Ser Thr Thr Val Gln Pro Asn Leu Glu Lys Glu Val Trp Gly Met 
225                 230                 235                 240 


Glu Asn Asn Ser Ser Glu Ser Ser Phe Ala Asp Ser Ser Val Val Ser 
                245                 250                 255     


Glu Ser Asp Thr Ser Leu Ala Glu Gly Ser Val Ser Cys Leu Asp Glu 
            260                 265                 270         


Ser Leu Gly His Asn Ser Asn Met Gly Ser Asp Ser Gly Thr Met Gly 
        275                 280                 285             


Ser Asp Ser Asp Glu Glu Asn Val Ala Ala Arg Ala Ser Pro Glu Pro 
    290                 295                 300                 


Glu Leu Gln Leu Arg Pro Tyr Gln Met Glu Val Ala Gln Pro Ala Leu 
305                 310                 315                 320 


Glu Gly Lys Asn Ile Ile Ile Cys Leu Pro Thr Gly Ser Gly Lys Thr 
                325                 330                 335     


Arg Val Ala Val Tyr Ile Ala Lys Asp His Leu Asp Lys Lys Lys Lys 
            340                 345                 350         


Ala Ser Glu Pro Gly Lys Val Ile Val Leu Val Asn Lys Val Leu Leu 
        355                 360                 365             


Val Glu Gln Leu Phe Arg Lys Glu Phe Gln Pro Phe Leu Lys Lys Trp 
    370                 375                 380                 


Tyr Arg Val Ile Gly Leu Ser Gly Asp Thr Gln Leu Lys Ile Ser Phe 
385                 390                 395                 400 


Pro Glu Val Val Lys Ser Cys Asp Ile Ile Ile Ser Thr Ala Gln Ile 
                405                 410                 415     


Leu Glu Asn Ser Leu Leu Asn Leu Glu Asn Gly Glu Asp Ala Gly Val 
            420                 425                 430         


Gln Leu Ser Asp Phe Ser Leu Ile Ile Ile Asp Glu Cys His His Thr 
        435                 440                 445             


Asn Lys Glu Ala Val Tyr Asn Asn Ile Met Arg His Tyr Leu Met Gln 
    450                 455                 460                 


Lys Leu Lys Asn Asn Arg Leu Lys Lys Glu Asn Lys Pro Val Ile Pro 
465                 470                 475                 480 


Leu Pro Gln Ile Leu Gly Leu Thr Ala Ser Pro Gly Val Gly Gly Ala 
                485                 490                 495     


Thr Lys Gln Ala Lys Ala Glu Glu His Ile Leu Lys Leu Cys Ala Asn 
            500                 505                 510         


Leu Asp Ala Phe Thr Ile Lys Thr Val Lys Glu Asn Leu Asp Gln Leu 
        515                 520                 525             


Lys Asn Gln Ile Gln Glu Pro Cys Lys Lys Phe Ala Ile Ala Asp Ala 
    530                 535                 540                 


Thr Arg Glu Asp Pro Phe Lys Glu Lys Leu Leu Glu Ile Met Thr Arg 
545                 550                 555                 560 


Ile Gln Thr Tyr Cys Gln Met Ser Pro Met Ser Asp Phe Gly Thr Gln 
                565                 570                 575     


Pro Tyr Glu Gln Trp Ala Ile Gln Met Glu Lys Lys Ala Ala Lys Glu 
            580                 585                 590         


Gly Asn Arg Lys Glu Arg Val Cys Ala Glu His Leu Arg Lys Tyr Asn 
        595                 600                 605             


Glu Ala Leu Gln Ile Asn Asp Thr Ile Arg Met Ile Asp Ala Tyr Thr 
    610                 615                 620                 


His Leu Glu Thr Phe Tyr Asn Glu Glu Lys Asp Lys Lys Phe Ala Val 
625                 630                 635                 640 


Ile Glu Asp Asp Ser Asp Glu Gly Gly Asp Asp Glu Tyr Cys Asp Gly 
                645                 650                 655     


Asp Glu Asp Glu Asp Asp Leu Lys Lys Pro Leu Lys Leu Asp Glu Thr 
            660                 665                 670         


Asp Arg Phe Leu Met Thr Leu Phe Phe Glu Asn Asn Lys Met Leu Lys 
        675                 680                 685             


Arg Leu Ala Glu Asn Pro Glu Tyr Glu Asn Glu Lys Leu Thr Lys Leu 
    690                 695                 700                 


Arg Asn Thr Ile Met Glu Gln Tyr Thr Arg Thr Glu Glu Ser Ala Arg 
705                 710                 715                 720 


Gly Ile Ile Phe Thr Lys Thr Arg Gln Ser Ala Tyr Ala Leu Ser Gln 
                725                 730                 735     


Trp Ile Thr Glu Asn Glu Lys Phe Ala Glu Val Gly Val Lys Ala His 
            740                 745                 750         


His Leu Ile Gly Ala Gly His Ser Ser Glu Phe Lys Pro Met Thr Gln 
        755                 760                 765             


Asn Glu Gln Lys Glu Val Ile Ser Lys Phe Arg Thr Gly Lys Ile Asn 
    770                 775                 780                 


Leu Leu Ile Ala Thr Thr Val Ala Glu Glu Gly Leu Asp Ile Lys Glu 
785                 790                 795                 800 


Cys Asn Ile Val Ile Arg Tyr Gly Leu Val Thr Asn Glu Ile Ala Met 
                805                 810                 815     


Val Gln Ala Arg Gly Arg Ala Arg Ala Asp Glu Ser Thr Tyr Val Leu 
            820                 825                 830         


Val Ala His Ser Gly Ser Gly Val Ile Glu His Glu Thr Val Asn Asp 
        835                 840                 845             


Phe Arg Glu Lys Met Met Tyr Lys Ala Ile His Cys Val Gln Asn Met 
    850                 855                 860                 


Lys Pro Glu Glu Tyr Ala His Lys Ile Leu Glu Leu Gln Met Gln Ser 
865                 870                 875                 880 


Ile Met Glu Lys Lys Met Lys Thr Lys Arg Asn Ile Ala Lys His Tyr 
                885                 890                 895     


Lys Asn Asn Pro Ser Leu Ile Thr Phe Leu Cys Lys Asn Cys Ser Val 
            900                 905                 910         


Leu Ala Cys Ser Gly Glu Asp Ile His Val Ile Glu Lys Met His His 
        915                 920                 925             


Val Asn Met Thr Pro Glu Phe Lys Glu Leu Tyr Ile Val Arg Glu Asn 
    930                 935                 940                 


Lys Ala Leu Gln Lys Lys Cys Ala Asp Tyr Gln Ile Asn Gly Glu Ile 
945                 950                 955                 960 


Ile Cys Lys Cys Gly Gln Ala Trp Gly Thr Met Met Val His Lys Gly 
                965                 970                 975     


Leu Asp Leu Pro Cys Leu Lys Ile Arg Asn Phe Val Val Val Phe Lys 
            980                 985                 990         


Asn Asn Ser Thr Lys Lys Gln Tyr  Lys Lys Trp Val Glu  Leu Pro Ile 
        995                 1000                 1005             


Thr Phe  Pro Asn Leu Asp Tyr  Ser Glu Cys Cys Leu  Phe Ser Asp 
    1010                 1015                 1020             


Glu Asp  
    1025 


<210>  91
<211>  4992
<212>  DNA
<213>  Homo sapiens

<400>  91
gaagactcca gatataggat cactccatgc catcaagaaa gttgatgcta ttgggcccat       60

ctcaagctga tcttggcacc tctcatgctc tgctctcttc aaccagacct ctacattcca      120

ttttggaaga agactaaaaa tggtgtttcc aatgtggaca ctgaagagac aaattcttat      180

cctttttaac ataatcctaa tttccaaact ccttggggct agatggtttc ctaaaactct      240

gccctgtgat gtcactctgg atgttccaaa gaaccatgtg atcgtggact gcacagacaa      300

gcatttgaca gaaattcctg gaggtattcc cacgaacacc acgaacctca ccctcaccat      360

taaccacata ccagacatct ccccagcgtc ctttcacaga ctggaccatc tggtagagat      420

cgatttcaga tgcaactgtg tacctattcc actggggtca aaaaacaaca tgtgcatcaa      480

gaggctgcag attaaaccca gaagctttag tggactcact tatttaaaat ccctttacct      540

ggatggaaac cagctactag agataccgca gggcctcccg cctagcttac agcttctcag      600

ccttgaggcc aacaacatct tttccatcag aaaagagaat ctaacagaac tggccaacat      660

agaaatactc tacctgggcc aaaactgtta ttatcgaaat ccttgttatg tttcatattc      720

aatagagaaa gatgccttcc taaacttgac aaagttaaaa gtgctctccc tgaaagataa      780

caatgtcaca gccgtcccta ctgttttgcc atctacttta acagaactat atctctacaa      840

caacatgatt gcaaaaatcc aagaagatga ttttaataac ctcaaccaat tacaaattct      900

tgacctaagt ggaaattgcc ctcgttgtta taatgcccca tttccttgtg cgccgtgtaa      960

aaataattct cccctacaga tccctgtaaa tgcttttgat gcgctgacag aattaaaagt     1020

tttacgtcta cacagtaact ctcttcagca tgtgccccca agatggttta agaacatcaa     1080

caaactccag gaactggatc tgtcccaaaa cttcttggcc aaagaaattg gggatgctaa     1140

atttctgcat tttctcccca gcctcatcca attggatctg tctttcaatt ttgaacttca     1200

ggtctatcgt gcatctatga atctatcaca agcattttct tcactgaaaa gcctgaaaat     1260

tctgcggatc agaggatatg tctttaaaga gttgaaaagc tttaacctct cgccattaca     1320

taatcttcaa aatcttgaag ttcttgatct tggcactaac tttataaaaa ttgctaacct     1380

cagcatgttt aaacaattta aaagactgaa agtcatagat ctttcagtga ataaaatatc     1440

accttcagga gattcaagtg aagttggctt ctgctcaaat gccagaactt ctgtagaaag     1500

ttatgaaccc caggtcctgg aacaattaca ttatttcaga tatgataagt atgcaaggag     1560

ttgcagattc aaaaacaaag aggcttcttt catgtctgtt aatgaaagct gctacaagta     1620

tgggcagacc ttggatctaa gtaaaaatag tatatttttt gtcaagtcct ctgattttca     1680

gcatctttct ttcctcaaat gcctgaatct gtcaggaaat ctcattagcc aaactcttaa     1740

tggcagtgaa ttccaacctt tagcagagct gagatatttg gacttctcca acaaccggct     1800

tgatttactc cattcaacag catttgaaga gcttcacaaa ctggaagttc tggatataag     1860

cagtaatagc cattattttc aatcagaagg aattactcat atgctaaact ttaccaagaa     1920

cctaaaggtt ctgcagaaac tgatgatgaa cgacaatgac atctcttcct ccaccagcag     1980

gaccatggag agtgagtctc ttagaactct ggaattcaga ggaaatcact tagatgtttt     2040

atggagagaa ggtgataaca gatacttaca attattcaag aatctgctaa aattagagga     2100

attagacatc tctaaaaatt ccctaagttt cttgccttct ggagtttttg atggtatgcc     2160

tccaaatcta aagaatctct ctttggccaa aaatgggctc aaatctttca gttggaagaa     2220

actccagtgt ctaaagaacc tggaaacttt ggacctcagc cacaaccaac tgaccactgt     2280

ccctgagaga ttatccaact gttccagaag cctcaagaat ctgattctta agaataatca     2340

aatcaggagt ctgacgaagt attttctaca agatgccttc cagttgcgat atctggatct     2400

cagctcaaat aaaatccaga tgatccaaaa gaccagcttc ccagaaaatg tcctcaacaa     2460

tctgaagatg ttgcttttgc atcataatcg gtttctgtgc acctgtgatg ctgtgtggtt     2520

tgtctggtgg gttaaccata cggaggtgac tattccttac ctggccacag atgtgacttg     2580

tgtggggcca ggagcacaca agggccaaag tgtgatctcc ctggatctgt acacctgtga     2640

gttagatctg actaacctga ttctgttctc actttccata tctgtatctc tctttctcat     2700

ggtgatgatg acagcaagtc acctctattt ctgggatgtg tggtatattt accatttctg     2760

taaggccaag ataaaggggt atcagcgtct aatatcacca gactgttgct atgatgcttt     2820

tattgtgtat gacactaaag acccagctgt gaccgagtgg gttttggctg agctggtggc     2880

caaactggaa gacccaagag agaaacattt taatttatgt ctcgaggaaa gggactggtt     2940

accagggcag ccagttctgg aaaacctttc ccagagcata cagcttagca aaaagacagt     3000

gtttgtgatg acagacaagt atgcaaagac tgaaaatttt aagatagcat tttacttgtc     3060

ccatcagagg ctcatggatg aaaaagttga tgtgattatc ttgatatttc ttgagaagcc     3120

ctttcagaag tccaagttcc tccagctccg gaaaaggctc tgtgggagtt ctgtccttga     3180

gtggccaaca aacccgcaag ctcacccata cttctggcag tgtctaaaga acgccctggc     3240

cacagacaat catgtggcct atagtcaggt gttcaaggaa acggtctagc ccttctttgc     3300

aaaacacaac tgcctagttt accaaggaga ggcctggctg tttaaattgt tttcatatat     3360

atcacaccaa aagcgtgttt tgaaattctt caagaaatga gattgcccat atttcagggg     3420

agccaccaac gtctgtcaca ggagttggaa agatggggtt tatataatgc atcaagtctt     3480

ctttcttatc tctctgtgtc tctatttgca cttgagtctc tcacctcagc tcctgtaaaa     3540

gagtggcaag taaaaaacat ggggctctga ttctcctgta attgtgataa ttaaatatac     3600

acacaatcat gacattgaga agaactgcat ttctaccctt aaaaagtact ggtatataca     3660

gaaatagggt taaaaaaaac tcaagctctc tctatatgag accaaaatgt actagagtta     3720

gtttagtgaa ataaaaaacc agtcagctgg ccgggcatgg tggctcatgc ttgtaatccc     3780

agcactttgg gaggccgagg caggtggatc acgaggtcag gagtttgaga ccagtctggc     3840

caacatggtg aaaccccgtc tgtactaaaa atacaaaaat tagctgggcg tggtggtggg     3900

tgcctgtaat cccagctact tgggaggctg aggcaggaga atcgcttgaa cccgggaggt     3960

ggaggtggca gtgagccgag atcacgccac tgcaatgcag cccgggcaac agagctagac     4020

tgtctcaaaa gaacaaaaaa aaaaaaacac aaaaaaactc agtcagcttc ttaaccaatt     4080

gcttccgtgt catccagggc cccattctgt gcagattgag tgtgggcacc acacaggtgg     4140

ttgctgcttc agtgcttcct gctctttttc cttgggcctg cttctgggtt ccatagggaa     4200

acagtaagaa agaaagacac atccttacca taaatgcata tggtccacct acaaatagaa     4260

aaatatttaa atgatctgcc tttatacaaa gtgatattct ctacctttga taatttacct     4320

gcttaaatgt ttttatctgc actgcaaagt actgtatcca aagtaaaatt tcctcatcca     4380

atatctttca aactgttttg ttaactaatg ccatatattt gtaagtatct gcacacttga     4440

tacagcaacg ttagatggtt ttgatggtaa accctaaagg aggactccaa gagtgtgtat     4500

ttatttatag ttttatcaga gatgacaatt atttgaatgc caattatatg gattcctttc     4560

attttttgct ggaggatggg agaagaaacc aaagtttata gaccttcaca ttgagaaagc     4620

ttcagttttg aacttcagct atcagattca aaaacaacag aaagaaccaa gacattctta     4680

agatgcctgt actttcagct gggtataaat tcatgagttc aaagattgaa acctgaccaa     4740

tttgctttat ttcatggaag aagtgatcta caaaggtgtt tgtgccattt ggaaaacagc     4800

gtgcatgtgt tcaagcctta gattggcgat gtcgtatttt cctcacgtgt ggcaatgcca     4860

aaggctttac tttacctgtg agtacacact atatgaatta tttccaacgt acatttaatc     4920

aataagggtc acaaattccc aaatcaatct ctggaataaa tagagaggta attaaattgc     4980

tggagccaac ta                                                         4992


<210>  92
<211>  1049
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe 
1               5                   10                  15      


Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Ala Arg Trp Phe Pro Lys 
            20                  25                  30          


Thr Leu Pro Cys Asp Val Thr Leu Asp Val Pro Lys Asn His Val Ile 
        35                  40                  45              


Val Asp Cys Thr Asp Lys His Leu Thr Glu Ile Pro Gly Gly Ile Pro 
    50                  55                  60                  


Thr Asn Thr Thr Asn Leu Thr Leu Thr Ile Asn His Ile Pro Asp Ile 
65                  70                  75                  80  


Ser Pro Ala Ser Phe His Arg Leu Asp His Leu Val Glu Ile Asp Phe 
                85                  90                  95      


Arg Cys Asn Cys Val Pro Ile Pro Leu Gly Ser Lys Asn Asn Met Cys 
            100                 105                 110         


Ile Lys Arg Leu Gln Ile Lys Pro Arg Ser Phe Ser Gly Leu Thr Tyr 
        115                 120                 125             


Leu Lys Ser Leu Tyr Leu Asp Gly Asn Gln Leu Leu Glu Ile Pro Gln 
    130                 135                 140                 


Gly Leu Pro Pro Ser Leu Gln Leu Leu Ser Leu Glu Ala Asn Asn Ile 
145                 150                 155                 160 


Phe Ser Ile Arg Lys Glu Asn Leu Thr Glu Leu Ala Asn Ile Glu Ile 
                165                 170                 175     


Leu Tyr Leu Gly Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Tyr Val Ser 
            180                 185                 190         


Tyr Ser Ile Glu Lys Asp Ala Phe Leu Asn Leu Thr Lys Leu Lys Val 
        195                 200                 205             


Leu Ser Leu Lys Asp Asn Asn Val Thr Ala Val Pro Thr Val Leu Pro 
    210                 215                 220                 


Ser Thr Leu Thr Glu Leu Tyr Leu Tyr Asn Asn Met Ile Ala Lys Ile 
225                 230                 235                 240 


Gln Glu Asp Asp Phe Asn Asn Leu Asn Gln Leu Gln Ile Leu Asp Leu 
                245                 250                 255     


Ser Gly Asn Cys Pro Arg Cys Tyr Asn Ala Pro Phe Pro Cys Ala Pro 
            260                 265                 270         


Cys Lys Asn Asn Ser Pro Leu Gln Ile Pro Val Asn Ala Phe Asp Ala 
        275                 280                 285             


Leu Thr Glu Leu Lys Val Leu Arg Leu His Ser Asn Ser Leu Gln His 
    290                 295                 300                 


Val Pro Pro Arg Trp Phe Lys Asn Ile Asn Lys Leu Gln Glu Leu Asp 
305                 310                 315                 320 


Leu Ser Gln Asn Phe Leu Ala Lys Glu Ile Gly Asp Ala Lys Phe Leu 
                325                 330                 335     


His Phe Leu Pro Ser Leu Ile Gln Leu Asp Leu Ser Phe Asn Phe Glu 
            340                 345                 350         


Leu Gln Val Tyr Arg Ala Ser Met Asn Leu Ser Gln Ala Phe Ser Ser 
        355                 360                 365             


Leu Lys Ser Leu Lys Ile Leu Arg Ile Arg Gly Tyr Val Phe Lys Glu 
    370                 375                 380                 


Leu Lys Ser Phe Asn Leu Ser Pro Leu His Asn Leu Gln Asn Leu Glu 
385                 390                 395                 400 


Val Leu Asp Leu Gly Thr Asn Phe Ile Lys Ile Ala Asn Leu Ser Met 
                405                 410                 415     


Phe Lys Gln Phe Lys Arg Leu Lys Val Ile Asp Leu Ser Val Asn Lys 
            420                 425                 430         


Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gly Phe Cys Ser Asn Ala 
        435                 440                 445             


Arg Thr Ser Val Glu Ser Tyr Glu Pro Gln Val Leu Glu Gln Leu His 
    450                 455                 460                 


Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys 
465                 470                 475                 480 


Glu Ala Ser Phe Met Ser Val Asn Glu Ser Cys Tyr Lys Tyr Gly Gln 
                485                 490                 495     


Thr Leu Asp Leu Ser Lys Asn Ser Ile Phe Phe Val Lys Ser Ser Asp 
            500                 505                 510         


Phe Gln His Leu Ser Phe Leu Lys Cys Leu Asn Leu Ser Gly Asn Leu 
        515                 520                 525             


Ile Ser Gln Thr Leu Asn Gly Ser Glu Phe Gln Pro Leu Ala Glu Leu 
    530                 535                 540                 


Arg Tyr Leu Asp Phe Ser Asn Asn Arg Leu Asp Leu Leu His Ser Thr 
545                 550                 555                 560 


Ala Phe Glu Glu Leu His Lys Leu Glu Val Leu Asp Ile Ser Ser Asn 
                565                 570                 575     


Ser His Tyr Phe Gln Ser Glu Gly Ile Thr His Met Leu Asn Phe Thr 
            580                 585                 590         


Lys Asn Leu Lys Val Leu Gln Lys Leu Met Met Asn Asp Asn Asp Ile 
        595                 600                 605             


Ser Ser Ser Thr Ser Arg Thr Met Glu Ser Glu Ser Leu Arg Thr Leu 
    610                 615                 620                 


Glu Phe Arg Gly Asn His Leu Asp Val Leu Trp Arg Glu Gly Asp Asn 
625                 630                 635                 640 


Arg Tyr Leu Gln Leu Phe Lys Asn Leu Leu Lys Leu Glu Glu Leu Asp 
                645                 650                 655     


Ile Ser Lys Asn Ser Leu Ser Phe Leu Pro Ser Gly Val Phe Asp Gly 
            660                 665                 670         


Met Pro Pro Asn Leu Lys Asn Leu Ser Leu Ala Lys Asn Gly Leu Lys 
        675                 680                 685             


Ser Phe Ser Trp Lys Lys Leu Gln Cys Leu Lys Asn Leu Glu Thr Leu 
    690                 695                 700                 


Asp Leu Ser His Asn Gln Leu Thr Thr Val Pro Glu Arg Leu Ser Asn 
705                 710                 715                 720 


Cys Ser Arg Ser Leu Lys Asn Leu Ile Leu Lys Asn Asn Gln Ile Arg 
                725                 730                 735     


Ser Leu Thr Lys Tyr Phe Leu Gln Asp Ala Phe Gln Leu Arg Tyr Leu 
            740                 745                 750         


Asp Leu Ser Ser Asn Lys Ile Gln Met Ile Gln Lys Thr Ser Phe Pro 
        755                 760                 765             


Glu Asn Val Leu Asn Asn Leu Lys Met Leu Leu Leu His His Asn Arg 
    770                 775                 780                 


Phe Leu Cys Thr Cys Asp Ala Val Trp Phe Val Trp Trp Val Asn His 
785                 790                 795                 800 


Thr Glu Val Thr Ile Pro Tyr Leu Ala Thr Asp Val Thr Cys Val Gly 
                805                 810                 815     


Pro Gly Ala His Lys Gly Gln Ser Val Ile Ser Leu Asp Leu Tyr Thr 
            820                 825                 830         


Cys Glu Leu Asp Leu Thr Asn Leu Ile Leu Phe Ser Leu Ser Ile Ser 
        835                 840                 845             


Val Ser Leu Phe Leu Met Val Met Met Thr Ala Ser His Leu Tyr Phe 
    850                 855                 860                 


Trp Asp Val Trp Tyr Ile Tyr His Phe Cys Lys Ala Lys Ile Lys Gly 
865                 870                 875                 880 


Tyr Gln Arg Leu Ile Ser Pro Asp Cys Cys Tyr Asp Ala Phe Ile Val 
                885                 890                 895     


Tyr Asp Thr Lys Asp Pro Ala Val Thr Glu Trp Val Leu Ala Glu Leu 
            900                 905                 910         


Val Ala Lys Leu Glu Asp Pro Arg Glu Lys His Phe Asn Leu Cys Leu 
        915                 920                 925             


Glu Glu Arg Asp Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu Ser 
    930                 935                 940                 


Gln Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Asp Lys 
945                 950                 955                 960 


Tyr Ala Lys Thr Glu Asn Phe Lys Ile Ala Phe Tyr Leu Ser His Gln 
                965                 970                 975     


Arg Leu Met Asp Glu Lys Val Asp Val Ile Ile Leu Ile Phe Leu Glu 
            980                 985                 990         


Lys Pro Phe Gln Lys Ser Lys Phe  Leu Gln Leu Arg Lys  Arg Leu Cys 
        995                 1000                 1005             


Gly Ser  Ser Val Leu Glu Trp  Pro Thr Asn Pro Gln  Ala His Pro 
    1010                 1015                 1020             


Tyr Phe  Trp Gln Cys Leu Lys  Asn Ala Leu Ala Thr  Asp Asn His 
    1025                 1030                 1035             


Val Ala  Tyr Ser Gln Val Phe  Lys Glu Thr Val 
    1040                 1045                 


<210>  93
<211>  1972
<212>  DNA
<213>  Homo sapiens

<400>  93
gaaactcccg cctggccacc ataaaagcgc cggccctccg cttccccgcg agacgaaact       60

tcccgtcccg gcggctctgg cacccagggt ccggcctgcg ccttcccgcc aggcctggac      120

actggttcaa cacctgtgac ttcatgtgtg cgcgccggcc acacctgcag tcacacctgt      180

agccccctct gccaagagat ccataccgag gcagcgtcgg tggctacaag ccctcagtcc      240

acacctgtgg acacctgtga cacctggcca cacgacctgt ggccgcggcc tggcgtctgc      300

tgcgacagga gcccttacct cccctgttat aacacctgac cgccacctaa ctgcccctgc      360

agaaggagca atggccttgg ctcctgagag ggcagcccca cgcgtgctgt tcggagagtg      420

gctccttgga gagatcagca gcggctgcta tgaggggctg cagtggctgg acgaggcccg      480

cacctgtttc cgcgtgccct ggaagcactt cgcgcgcaag gacctgagcg aggccgacgc      540

gcgcatcttc aaggcctggg ctgtggcccg cggcaggtgg ccgcctagca gcaggggagg      600

tggcccgccc cccgaggctg agactgcgga gcgcgccggc tggaaaacca acttccgctg      660

cgcactgcgc agcacgcgtc gcttcgtgat gctgcgggat aactcggggg acccggccga      720

cccgcacaag gtgtacgcgc tcagccggga gctgtgctgg cgagaaggcc caggcacgga      780

ccagactgag gcagaggccc ccgcagctgt cccaccacca cagggtgggc ccccagggcc      840

attcctggca cacacacatg ctggactcca agccccaggc cccctccctg ccccagctgg      900

tgacaagggg gacctcctgc tccaggcagt gcaacagagc tgcctggcag accatctgct      960

gacagcgtca tggggggcag atccagtccc aaccaaggct cctggagagg gacaagaagg     1020

gcttcccctg actggggcct gtgctggagg cccagggctc cctgctgggg agctgtacgg     1080

gtgggcagta gagacgaccc ccagccccgg gccccagccc gcggcactaa cgacaggcga     1140

ggccgcggcc ccagagtccc cgcaccaggc agagccgtac ctgtcaccct ccccaagcgc     1200

ctgcaccgcg gtgcaagagc ccagcccagg ggcgctggac gtgaccatca tgtacaaggg     1260

ccgcacggtg ctgcagaagg tggtgggaca cccgagctgc acgttcctat acggcccccc     1320

agacccagct gtccgggcca cagaccccca gcaggtagca ttccccagcc ctgccgagct     1380

cccggaccag aagcagctgc gctacacgga ggaactgctg cggcacgtgg cccctgggtt     1440

gcacctggag cttcgggggc cacagctgtg ggcccggcgc atgggcaagt gcaaggtgta     1500

ctgggaggtg ggcggacccc caggctccgc cagcccctcc accccagcct gcctgctgcc     1560

tcggaactgt gacaccccca tcttcgactt cagagtcttc ttccaagagc tggtggaatt     1620

ccgggcacgg cagcgccgtg gctccccacg ctataccatc tacctgggct tcgggcagga     1680

cctgtcagct gggaggccca aggagaagag cctggtcctg gtgaagctgg aaccctggct     1740

gtgccgagtg cacctagagg gcacgcagcg tgagggtgtg tcttccctgg atagcagcag     1800

cctcagcctc tgcctgtcca gcgccaacag cctctatgac gacatcgagt gcttccttat     1860

ggagctggag cagcccgcct agaacccagt ctaatgagaa ctccagaaag ctggagcagc     1920

ccacctagag ctggccgcgg ccgcccagtc taataaaaag aactccagaa ca             1972


<210>  94
<211>  503
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ala Leu Ala Pro Glu Arg Ala Ala Pro Arg Val Leu Phe Gly Glu 
1               5                   10                  15      


Trp Leu Leu Gly Glu Ile Ser Ser Gly Cys Tyr Glu Gly Leu Gln Trp 
            20                  25                  30          


Leu Asp Glu Ala Arg Thr Cys Phe Arg Val Pro Trp Lys His Phe Ala 
        35                  40                  45              


Arg Lys Asp Leu Ser Glu Ala Asp Ala Arg Ile Phe Lys Ala Trp Ala 
    50                  55                  60                  


Val Ala Arg Gly Arg Trp Pro Pro Ser Ser Arg Gly Gly Gly Pro Pro 
65                  70                  75                  80  


Pro Glu Ala Glu Thr Ala Glu Arg Ala Gly Trp Lys Thr Asn Phe Arg 
                85                  90                  95      


Cys Ala Leu Arg Ser Thr Arg Arg Phe Val Met Leu Arg Asp Asn Ser 
            100                 105                 110         


Gly Asp Pro Ala Asp Pro His Lys Val Tyr Ala Leu Ser Arg Glu Leu 
        115                 120                 125             


Cys Trp Arg Glu Gly Pro Gly Thr Asp Gln Thr Glu Ala Glu Ala Pro 
    130                 135                 140                 


Ala Ala Val Pro Pro Pro Gln Gly Gly Pro Pro Gly Pro Phe Leu Ala 
145                 150                 155                 160 


His Thr His Ala Gly Leu Gln Ala Pro Gly Pro Leu Pro Ala Pro Ala 
                165                 170                 175     


Gly Asp Lys Gly Asp Leu Leu Leu Gln Ala Val Gln Gln Ser Cys Leu 
            180                 185                 190         


Ala Asp His Leu Leu Thr Ala Ser Trp Gly Ala Asp Pro Val Pro Thr 
        195                 200                 205             


Lys Ala Pro Gly Glu Gly Gln Glu Gly Leu Pro Leu Thr Gly Ala Cys 
    210                 215                 220                 


Ala Gly Gly Pro Gly Leu Pro Ala Gly Glu Leu Tyr Gly Trp Ala Val 
225                 230                 235                 240 


Glu Thr Thr Pro Ser Pro Gly Pro Gln Pro Ala Ala Leu Thr Thr Gly 
                245                 250                 255     


Glu Ala Ala Ala Pro Glu Ser Pro His Gln Ala Glu Pro Tyr Leu Ser 
            260                 265                 270         


Pro Ser Pro Ser Ala Cys Thr Ala Val Gln Glu Pro Ser Pro Gly Ala 
        275                 280                 285             


Leu Asp Val Thr Ile Met Tyr Lys Gly Arg Thr Val Leu Gln Lys Val 
    290                 295                 300                 


Val Gly His Pro Ser Cys Thr Phe Leu Tyr Gly Pro Pro Asp Pro Ala 
305                 310                 315                 320 


Val Arg Ala Thr Asp Pro Gln Gln Val Ala Phe Pro Ser Pro Ala Glu 
                325                 330                 335     


Leu Pro Asp Gln Lys Gln Leu Arg Tyr Thr Glu Glu Leu Leu Arg His 
            340                 345                 350         


Val Ala Pro Gly Leu His Leu Glu Leu Arg Gly Pro Gln Leu Trp Ala 
        355                 360                 365             


Arg Arg Met Gly Lys Cys Lys Val Tyr Trp Glu Val Gly Gly Pro Pro 
    370                 375                 380                 


Gly Ser Ala Ser Pro Ser Thr Pro Ala Cys Leu Leu Pro Arg Asn Cys 
385                 390                 395                 400 


Asp Thr Pro Ile Phe Asp Phe Arg Val Phe Phe Gln Glu Leu Val Glu 
                405                 410                 415     


Phe Arg Ala Arg Gln Arg Arg Gly Ser Pro Arg Tyr Thr Ile Tyr Leu 
            420                 425                 430         


Gly Phe Gly Gln Asp Leu Ser Ala Gly Arg Pro Lys Glu Lys Ser Leu 
        435                 440                 445             


Val Leu Val Lys Leu Glu Pro Trp Leu Cys Arg Val His Leu Glu Gly 
    450                 455                 460                 


Thr Gln Arg Glu Gly Val Ser Ser Leu Asp Ser Ser Ser Leu Ser Leu 
465                 470                 475                 480 


Cys Leu Ser Ser Ala Asn Ser Leu Tyr Asp Asp Ile Glu Cys Phe Leu 
                485                 490                 495     


Met Glu Leu Glu Gln Pro Ala 
            500             


<210>  95
<211>  1885
<212>  DNA
<213>  Homo sapiens

<400>  95
gaaactcccg cctggccacc ataaaagcgc cggccctccg cttccccgcg agacgaaact       60

tcccgtcccg gcggctctgg cacccagggt ccggcctgcg ccttcccgcc aggcctggac      120

actggttcaa cacctgtgac ttcatgtgtg cgcgccggcc acacctgcag tcacacctgt      180

agccccctct gccaagagat ccataccgag gcagcgtcgg tggctacaag ccctcagtcc      240

acacctgtgg acacctgtga cacctggcca cacgacctgt ggccgcggcc tggcgtctgc      300

tgcgacagga gcccttacct cccctgttat aacacctgac cgccacctaa ctgcccctgc      360

agaaggagca atggccttgg ctcctgagag ggcagcccca cgcgtgctgt tcggagagtg      420

gctccttgga gagatcagca gcggctgcta tgaggggctg cagtggctgg acgaggcccg      480

cacctgtttc cgcgtgccct ggaagcactt cgcgcgcaag gacctgagcg aggccgacgc      540

gcgcatcttc aaggcctggg ctgtggcccg cggcaggtgg ccgcctagca gcaggggagg      600

tggcccgccc cccgaggctg agactgcgga gcgcgccggc tggaaaacca acttccgctg      660

cgcactgcgc agcacgcgtc gcttcgtgat gctgcgggat aactcggggg acccggccga      720

cccgcacaag gtgtacgcgc tcagccggga gctgtgctgg cgagaaggcc caggcacgga      780

ccagactgag gcagaggccc ccgcagctgt cccaccacca cagggtgggc ccccagggcc      840

attcctggca cacacacatg ctggactcca agccccaggc cccctccctg ccccagctgg      900

tgacaagggg gacctcctgc tccaggcagt gcaacagagc tgcctggcag accatctgct      960

gacagcgtca tggggggcag atccagtccc aaccaaggct cctggagagg gacaagaagg     1020

gcttcccctg actggggcct gtgctggagg cgaggccgcg gccccagagt ccccgcacca     1080

ggcagagccg tacctgtcac cctccccaag cgcctgcacc gcggtgcaag agcccagccc     1140

aggggcgctg gacgtgacca tcatgtacaa gggccgcacg gtgctgcaga aggtggtggg     1200

acacccgagc tgcacgttcc tatacggccc cccagaccca gctgtccggg ccacagaccc     1260

ccagcaggta gcattcccca gccctgccga gctcccggac cagaagcagc tgcgctacac     1320

ggaggaactg ctgcggcacg tggcccctgg gttgcacctg gagcttcggg ggccacagct     1380

gtgggcccgg cgcatgggca agtgcaaggt gtactgggag gtgggcggac ccccaggctc     1440

cgccagcccc tccaccccag cctgcctgct gcctcggaac tgtgacaccc ccatcttcga     1500

cttcagagtc ttcttccaag agctggtgga attccgggca cggcagcgcc gtggctcccc     1560

acgctatacc atctacctgg gcttcgggca ggacctgtca gctgggaggc ccaaggagaa     1620

gagcctggtc ctggtgaagc tggaaccctg gctgtgccga gtgcacctag agggcacgca     1680

gcgtgagggt gtgtcttccc tggatagcag cagcctcagc ctctgcctgt ccagcgccaa     1740

cagcctctat gacgacatcg agtgcttcct tatggagctg gagcagcccg cctagaaccc     1800

agtctaatga gaactccaga aagctggagc agcccaccta gagctggccg cggccgccca     1860

gtctaataaa aagaactcca gaaca                                           1885


<210>  96
<211>  474
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Leu Ala Pro Glu Arg Ala Ala Pro Arg Val Leu Phe Gly Glu 
1               5                   10                  15      


Trp Leu Leu Gly Glu Ile Ser Ser Gly Cys Tyr Glu Gly Leu Gln Trp 
            20                  25                  30          


Leu Asp Glu Ala Arg Thr Cys Phe Arg Val Pro Trp Lys His Phe Ala 
        35                  40                  45              


Arg Lys Asp Leu Ser Glu Ala Asp Ala Arg Ile Phe Lys Ala Trp Ala 
    50                  55                  60                  


Val Ala Arg Gly Arg Trp Pro Pro Ser Ser Arg Gly Gly Gly Pro Pro 
65                  70                  75                  80  


Pro Glu Ala Glu Thr Ala Glu Arg Ala Gly Trp Lys Thr Asn Phe Arg 
                85                  90                  95      


Cys Ala Leu Arg Ser Thr Arg Arg Phe Val Met Leu Arg Asp Asn Ser 
            100                 105                 110         


Gly Asp Pro Ala Asp Pro His Lys Val Tyr Ala Leu Ser Arg Glu Leu 
        115                 120                 125             


Cys Trp Arg Glu Gly Pro Gly Thr Asp Gln Thr Glu Ala Glu Ala Pro 
    130                 135                 140                 


Ala Ala Val Pro Pro Pro Gln Gly Gly Pro Pro Gly Pro Phe Leu Ala 
145                 150                 155                 160 


His Thr His Ala Gly Leu Gln Ala Pro Gly Pro Leu Pro Ala Pro Ala 
                165                 170                 175     


Gly Asp Lys Gly Asp Leu Leu Leu Gln Ala Val Gln Gln Ser Cys Leu 
            180                 185                 190         


Ala Asp His Leu Leu Thr Ala Ser Trp Gly Ala Asp Pro Val Pro Thr 
        195                 200                 205             


Lys Ala Pro Gly Glu Gly Gln Glu Gly Leu Pro Leu Thr Gly Ala Cys 
    210                 215                 220                 


Ala Gly Gly Glu Ala Ala Ala Pro Glu Ser Pro His Gln Ala Glu Pro 
225                 230                 235                 240 


Tyr Leu Ser Pro Ser Pro Ser Ala Cys Thr Ala Val Gln Glu Pro Ser 
                245                 250                 255     


Pro Gly Ala Leu Asp Val Thr Ile Met Tyr Lys Gly Arg Thr Val Leu 
            260                 265                 270         


Gln Lys Val Val Gly His Pro Ser Cys Thr Phe Leu Tyr Gly Pro Pro 
        275                 280                 285             


Asp Pro Ala Val Arg Ala Thr Asp Pro Gln Gln Val Ala Phe Pro Ser 
    290                 295                 300                 


Pro Ala Glu Leu Pro Asp Gln Lys Gln Leu Arg Tyr Thr Glu Glu Leu 
305                 310                 315                 320 


Leu Arg His Val Ala Pro Gly Leu His Leu Glu Leu Arg Gly Pro Gln 
                325                 330                 335     


Leu Trp Ala Arg Arg Met Gly Lys Cys Lys Val Tyr Trp Glu Val Gly 
            340                 345                 350         


Gly Pro Pro Gly Ser Ala Ser Pro Ser Thr Pro Ala Cys Leu Leu Pro 
        355                 360                 365             


Arg Asn Cys Asp Thr Pro Ile Phe Asp Phe Arg Val Phe Phe Gln Glu 
    370                 375                 380                 


Leu Val Glu Phe Arg Ala Arg Gln Arg Arg Gly Ser Pro Arg Tyr Thr 
385                 390                 395                 400 


Ile Tyr Leu Gly Phe Gly Gln Asp Leu Ser Ala Gly Arg Pro Lys Glu 
                405                 410                 415     


Lys Ser Leu Val Leu Val Lys Leu Glu Pro Trp Leu Cys Arg Val His 
            420                 425                 430         


Leu Glu Gly Thr Gln Arg Glu Gly Val Ser Ser Leu Asp Ser Ser Ser 
        435                 440                 445             


Leu Ser Leu Cys Leu Ser Ser Ala Asn Ser Leu Tyr Asp Asp Ile Glu 
    450                 455                 460                 


Cys Phe Leu Met Glu Leu Glu Gln Pro Ala 
465                 470                 


<210>  97
<211>  860
<212>  DNA
<213>  Homo sapiens

<400>  97
ccagccttca gccggagaac cgtttactcg ctgctgtgcc catctatcag caggctccgg       60

gctgaagatt gcttctcttc tctcctccaa ggtctagtga cggagcccgc gcgcggcgcc      120

accatgcggc agaaggcggt atcgcttttc ttgtgctacc tgctgctctt cacttgcagt      180

ggggtggagg caggtgagaa tgcgggtaag gatgcaggta agaaaaagtg ctcggagagc      240

tcggacagcg gctccgggtt ctggaaggcc ctgaccttca tggccgtcgg aggaggactc      300

gcagtcgccg ggctgcccgc gctgggcttc accggcgccg gcatcgcggc caactcggtg      360

gctgcctcgc tgatgagctg gtctgcgatc ctgaatgggg gcggcgtgcc cgccgggggg      420

ctagtggcca cgctgcagag cctcggggct ggtggcagca gcgtcgtcat aggtaatatt      480

ggtgccctga tgggctacgc cacccacaag tatctcgata gtgaggagga tgaggagtag      540

ccagcagctc ccagaacctc ttcttccttc ttggcctaac tcttccagtt aggatctaga      600

actttgcctt tttttttttt tttttttttt tgagatgggt tctcactata ttgtccaggc      660

tagagtgcag tggctattca cagatgcgaa catagtacac tgcagcctcc aactcctagc      720

ctcaagtgat cctcctgtct caacctccca agtaggatta caagcatgcg ccgacgatgc      780

ccagaatcca gaactttgtc tatcactctc cccaacaacc tagatgtgaa aacagaataa      840

acttcaccca gaaaacactt                                                  860


<210>  98
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Arg Gln Lys Ala Val Ser Leu Phe Leu Cys Tyr Leu Leu Leu Phe 
1               5                   10                  15      


Thr Cys Ser Gly Val Glu Ala Gly Glu Asn Ala Gly Lys Asp Ala Gly 
            20                  25                  30          


Lys Lys Lys Cys Ser Glu Ser Ser Asp Ser Gly Ser Gly Phe Trp Lys 
        35                  40                  45              


Ala Leu Thr Phe Met Ala Val Gly Gly Gly Leu Ala Val Ala Gly Leu 
    50                  55                  60                  


Pro Ala Leu Gly Phe Thr Gly Ala Gly Ile Ala Ala Asn Ser Val Ala 
65                  70                  75                  80  


Ala Ser Leu Met Ser Trp Ser Ala Ile Leu Asn Gly Gly Gly Val Pro 
                85                  90                  95      


Ala Gly Gly Leu Val Ala Thr Leu Gln Ser Leu Gly Ala Gly Gly Ser 
            100                 105                 110         


Ser Val Val Ile Gly Asn Ile Gly Ala Leu Met Gly Tyr Ala Thr His 
        115                 120                 125             


Lys Tyr Leu Asp Ser Glu Glu Asp Glu Glu 
    130                 135             


<210>  99
<211>  848
<212>  DNA
<213>  Homo sapiens

<400>  99
ccagccttca gccggagaac cgtttactcg ctgctgtgcc catctatcag caggctccgg       60

gctgaagatt gcttctcttc tctcctccaa ggtctagtga cggagcccgc gcgcggcgcc      120

accatgcggc agaaggcggt atcgcttttc ttgtgctacc tgctgctctt cacttgcagt      180

ggggtggagg caggtgagaa tgcgggtaag aaaaagtgct cggagagctc ggacagcggc      240

tccgggttct ggaaggccct gaccttcatg gccgtcggag gaggactcgc agtcgccggg      300

ctgcccgcgc tgggcttcac cggcgccggc atcgcggcca actcggtggc tgcctcgctg      360

atgagctggt ctgcgatcct gaatgggggc ggcgtgcccg ccggggggct agtggccacg      420

ctgcagagcc tcggggctgg tggcagcagc gtcgtcatag gtaatattgg tgccctgatg      480

ggctacgcca cccacaagta tctcgatagt gaggaggatg aggagtagcc agcagctccc      540

agaacctctt cttccttctt ggcctaactc ttccagttag gatctagaac tttgcctttt      600

tttttttttt tttttttttg agatgggttc tcactatatt gtccaggcta gagtgcagtg      660

gctattcaca gatgcgaaca tagtacactg cagcctccaa ctcctagcct caagtgatcc      720

tcctgtctca acctcccaag taggattaca agcatgcgcc gacgatgccc agaatccaga      780

actttgtcta tcactctccc caacaaccta gatgtgaaaa cagaataaac ttcacccaga      840

aaacactt                                                               848


<210>  100
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Arg Gln Lys Ala Val Ser Leu Phe Leu Cys Tyr Leu Leu Leu Phe 
1               5                   10                  15      


Thr Cys Ser Gly Val Glu Ala Gly Glu Asn Ala Gly Lys Lys Lys Cys 
            20                  25                  30          


Ser Glu Ser Ser Asp Ser Gly Ser Gly Phe Trp Lys Ala Leu Thr Phe 
        35                  40                  45              


Met Ala Val Gly Gly Gly Leu Ala Val Ala Gly Leu Pro Ala Leu Gly 
    50                  55                  60                  


Phe Thr Gly Ala Gly Ile Ala Ala Asn Ser Val Ala Ala Ser Leu Met 
65                  70                  75                  80  


Ser Trp Ser Ala Ile Leu Asn Gly Gly Gly Val Pro Ala Gly Gly Leu 
                85                  90                  95      


Val Ala Thr Leu Gln Ser Leu Gly Ala Gly Gly Ser Ser Val Val Ile 
            100                 105                 110         


Gly Asn Ile Gly Ala Leu Met Gly Tyr Ala Thr His Lys Tyr Leu Asp 
        115                 120                 125             


Ser Glu Glu Asp Glu Glu 
    130                 


<210>  101
<211>  836
<212>  DNA
<213>  Homo sapiens

<400>  101
ccagccttca gccggagaac cgtttactcg ctgctgtgcc catctatcag caggctccgg       60

gctgaagatt gcttctcttc tctcctccaa ggtctagtga cggagcccgc gcgcggcgcc      120

accatgcggc agaaggcggt atcgcttttc ttgtgctacc tgctgctctt cacttgcagt      180

ggggtggagg caggtaagaa aaagtgctcg gagagctcgg acagcggctc cgggttctgg      240

aaggccctga ccttcatggc cgtcggagga ggactcgcag tcgccgggct gcccgcgctg      300

ggcttcaccg gcgccggcat cgcggccaac tcggtggctg cctcgctgat gagctggtct      360

gcgatcctga atgggggcgg cgtgcccgcc ggggggctag tggccacgct gcagagcctc      420

ggggctggtg gcagcagcgt cgtcataggt aatattggtg ccctgatggg ctacgccacc      480

cacaagtatc tcgatagtga ggaggatgag gagtagccag cagctcccag aacctcttct      540

tccttcttgg cctaactctt ccagttagga tctagaactt tgcctttttt tttttttttt      600

tttttttgag atgggttctc actatattgt ccaggctaga gtgcagtggc tattcacaga      660

tgcgaacata gtacactgca gcctccaact cctagcctca agtgatcctc ctgtctcaac      720

ctcccaagta ggattacaag catgcgccga cgatgcccag aatccagaac tttgtctatc      780

actctcccca acaacctaga tgtgaaaaca gaataaactt cacccagaaa acactt          836


<210>  102
<211>  130
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Arg Gln Lys Ala Val Ser Leu Phe Leu Cys Tyr Leu Leu Leu Phe 
1               5                   10                  15      


Thr Cys Ser Gly Val Glu Ala Gly Lys Lys Lys Cys Ser Glu Ser Ser 
            20                  25                  30          


Asp Ser Gly Ser Gly Phe Trp Lys Ala Leu Thr Phe Met Ala Val Gly 
        35                  40                  45              


Gly Gly Leu Ala Val Ala Gly Leu Pro Ala Leu Gly Phe Thr Gly Ala 
    50                  55                  60                  


Gly Ile Ala Ala Asn Ser Val Ala Ala Ser Leu Met Ser Trp Ser Ala 
65                  70                  75                  80  


Ile Leu Asn Gly Gly Gly Val Pro Ala Gly Gly Leu Val Ala Thr Leu 
                85                  90                  95      


Gln Ser Leu Gly Ala Gly Gly Ser Ser Val Val Ile Gly Asn Ile Gly 
            100                 105                 110         


Ala Leu Met Gly Tyr Ala Thr His Lys Tyr Leu Asp Ser Glu Glu Asp 
        115                 120                 125             


Glu Glu 
    130 


<210>  103
<211>  4326
<212>  DNA
<213>  Homo sapiens

<400>  103
gctgagcgcg gagccgcccg gtgattggtg ggggcggaag ggggccgggc gccagcgctg       60

ccttttctcc tgccgggtag tttcgctttc ctgcgcagag tctgcggagg ggctcggctg      120

caccgggggg atcgcgcctg gcagacccca gaccgagcag aggcgaccca gcgcgctcgg      180

gagaggctgc accgccgcgc ccccgcctag cccttccgga tcctgcgcgc agaaaagttt      240

catttgctgt atgccatcct cgagagctgt ctaggttaac gttcgcactc tgtgtatata      300

acctcgacag tcttggcacc taacgtgctg tgcgtagctg ctcctttggt tgaatcccca      360

ggcccttgtt ggggcacaag gtggcaggat gtctcagtgg tacgaacttc agcagcttga      420

ctcaaaattc ctggagcagg ttcaccagct ttatgatgac agttttccca tggaaatcag      480

acagtacctg gcacagtggt tagaaaagca agactgggag cacgctgcca atgatgtttc      540

atttgccacc atccgttttc atgacctcct gtcacagctg gatgatcaat atagtcgctt      600

ttctttggag aataacttct tgctacagca taacataagg aaaagcaagc gtaatcttca      660

ggataatttt caggaagacc caatccagat gtctatgatc atttacagct gtctgaagga      720

agaaaggaaa attctggaaa acgcccagag atttaatcag gctcagtcgg ggaatattca      780

gagcacagtg atgttagaca aacagaaaga gcttgacagt aaagtcagaa atgtgaagga      840

caaggttatg tgtatagagc atgaaatcaa gagcctggaa gatttacaag atgaatatga      900

cttcaaatgc aaaaccttgc agaacagaga acacgagacc aatggtgtgg caaagagtga      960

tcagaaacaa gaacagctgt tactcaagaa gatgtattta atgcttgaca ataagagaaa     1020

ggaagtagtt cacaaaataa tagagttgct gaatgtcact gaacttaccc agaatgccct     1080

gattaatgat gaactagtgg agtggaagcg gagacagcag agcgcctgta ttggggggcc     1140

gcccaatgct tgcttggatc agctgcagaa ctggttcact atagttgcgg agagtctgca     1200

gcaagttcgg cagcagctta aaaagttgga ggaattggaa cagaaataca cctacgaaca     1260

tgaccctatc acaaaaaaca aacaagtgtt atgggaccgc accttcagtc ttttccagca     1320

gctcattcag agctcgtttg tggtggaaag acagccctgc atgccaacgc accctcagag     1380

gccgctggtc ttgaagacag gggtccagtt cactgtgaag ttgagactgt tggtgaaatt     1440

gcaagagctg aattataatt tgaaagtcaa agtcttattt gataaagatg tgaatgagag     1500

aaatacagta aaaggattta ggaagttcaa cattttgggc acgcacacaa aagtgatgaa     1560

catggaggag tccaccaatg gcagtctggc ggctgaattt cggcacctgc aattgaaaga     1620

acagaaaaat gctggcacca gaacgaatga gggtcctctc atcgttactg aagagcttca     1680

ctcccttagt tttgaaaccc aattgtgcca gcctggtttg gtaattgacc tcgagacgac     1740

ctctctgccc gttgtggtga tctccaacgt cagccagctc ccgagcggtt gggcctccat     1800

cctttggtac aacatgctgg tggcggaacc caggaatctg tccttcttcc tgactccacc     1860

atgtgcacga tgggctcagc tttcagaagt gctgagttgg cagttttctt ctgtcaccaa     1920

aagaggtctc aatgtggacc agctgaacat gttgggagag aagcttcttg gtcctaacgc     1980

cagccccgat ggtctcattc cgtggacgag gttttgtaag gaaaatataa atgataaaaa     2040

ttttcccttc tggctttgga ttgaaagcat cctagaactc attaaaaaac acctgctccc     2100

tctctggaat gatgggtgca tcatgggctt catcagcaag gagcgagagc gtgccctgtt     2160

gaaggaccag cagccgggga ccttcctgct gcggttcagt gagagctccc gggaaggggc     2220

catcacattc acatgggtgg agcggtccca gaacggaggc gaacctgact tccatgcggt     2280

tgaaccctac acgaagaaag aactttctgc tgttactttc cctgacatca ttcgcaatta     2340

caaagtcatg gctgctgaga atattcctga gaatcccctg aagtatctgt atccaaatat     2400

tgacaaagac catgcctttg gaaagtatta ctccaggcca aaggaagcac cagagccaat     2460

ggaacttgat ggccctaaag gaactggata tatcaagact gagttgattt ctgtgtctga     2520

agttcaccct tctagacttc agaccacaga caacctgctc cccatgtctc ctgaggagtt     2580

tgacgaggtg tctcggatag tgggctctgt agaattcgac agtatgatga acacagtata     2640

gagcatgaat ttttttcatc ttctctggcg acagttttcc ttctcatctg tgattccctc     2700

ctgctactct gttccttcac atcctgtgtt tctagggaaa tgaaagaaag gccagcaaat     2760

tcgctgcaac ctgttgatag caagtgaatt tttctctaac tcagaaacat cagttactct     2820

gaagggcatc atgcatctta ctgaaggtaa aattgaaagg cattctctga agagtgggtt     2880

tcacaagtga aaaacatcca gatacaccca aagtatcagg acgagaatga gggtcctttg     2940

ggaaaggaga agttaagcaa catctagcaa atgttatgca taaagtcagt gcccaactgt     3000

tataggttgt tggataaatc agtggttatt tagggaactg cttgacgtag gaacggtaaa     3060

tttctgtggg agaattctta catgttttct ttgctttaag tgtaactggc agttttccat     3120

tggtttacct gtgaaatagt tcaaagccaa gtttatatac aattatatca gtcctctttc     3180

aaaggtagcc atcatggatc tggtaggggg aaaatgtgta ttttattaca tctttcacat     3240

tggctattta aagacaaaga caaattctgt ttcttgagaa gagaatatta gctttactgt     3300

ttgttatggc ttaatgacac tagctaatat caatagaagg atgtacattt ccaaattcac     3360

aagttgtgtt tgatatccaa agctgaatac attctgcttt catcttggtc acatacaatt     3420

atttttacag ttctcccaag ggagttaggc tattcacaac cactcattca aaagttgaaa     3480

ttaaccatag atgtagataa actcagaaat ttaattcatg tttcttaaat gggctacttt     3540

gtcctttttg ttattagggt ggtatttagt ctattagcca caaaattggg aaaggagtag     3600

aaaaagcagt aactgacaac ttgaataata caccagagat aatatgagaa tcagatcatt     3660

tcaaaactca tttcctatgt aactgcattg agaactgcat atgtttcgct gatatatgtg     3720

tttttcacat ttgcgaatgg ttccattctc tctcctgtac tttttccaga cacttttttg     3780

agtggatgat gtttcgtgaa gtatactgta tttttacctt tttccttcct tatcactgac     3840

acaaaaagta gattaagaga tgggtttgac aaggttcttc ccttttacat actgctgtct     3900

atgtggctgt atcttgtttt tccactactg ctaccacaac tatattatca tgcaaatgct     3960

gtattcttct ttggtggaga taaagatttc ttgagttttg ttttaaaatt aaagctaaag     4020

tatctgtatt gcattaaata taatatgcac acagtgcttt ccgtggcact gcatacaatc     4080

tgaggcctcc tctctcagtt tttatataga tggcgagaac ctaagtttca gttgatttta     4140

caattgaaat gactaaaaaa caaagaagac aacattaaaa caatattgtt tctaattgct     4200

gaggtttagc tgtcagttct ttttgccctt tgggaattcg gcatggtttc attttactgc     4260

actagccaag agactttact tttaagaagt attaaaattc taaaattcaa aaaaaaaaaa     4320

aaaaaa                                                                4326


<210>  104
<211>  2798
<212>  DNA
<213>  Homo sapiens

<400>  104
gctgagcgcg gagccgcccg gtgattggtg ggggcggaag ggggccgggc gccagcgctg       60

ccttttctcc tgccgggtag tttcgctttc ctgcgcagag tctgcggagg ggctcggctg      120

caccgggggg atcgcgcctg gcagacccca gaccgagcag aggcgaccca gcgcgctcgg      180

gagaggctgc accgccgcgc ccccgcctag cccttccgga tcctgcgcgc agaaaagttt      240

catttgctgt atgccatcct cgagagctgt ctaggttaac gttcgcactc tgtgtatata      300

acctcgacag tcttggcacc taacgtgctg tgcgtagctg ctcctttggt tgaatcccca      360

ggcccttgtt ggggcacaag gtggcaggat gtctcagtgg tacgaacttc agcagcttga      420

ctcaaaattc ctggagcagg ttcaccagct ttatgatgac agttttccca tggaaatcag      480

acagtacctg gcacagtggt tagaaaagca agactgggag cacgctgcca atgatgtttc      540

atttgccacc atccgttttc atgacctcct gtcacagctg gatgatcaat atagtcgctt      600

ttctttggag aataacttct tgctacagca taacataagg aaaagcaagc gtaatcttca      660

ggataatttt caggaagacc caatccagat gtctatgatc atttacagct gtctgaagga      720

agaaaggaaa attctggaaa acgcccagag atttaatcag gctcagtcgg ggaatattca      780

gagcacagtg atgttagaca aacagaaaga gcttgacagt aaagtcagaa atgtgaagga      840

caaggttatg tgtatagagc atgaaatcaa gagcctggaa gatttacaag atgaatatga      900

cttcaaatgc aaaaccttgc agaacagaga acacgagacc aatggtgtgg caaagagtga      960

tcagaaacaa gaacagctgt tactcaagaa gatgtattta atgcttgaca ataagagaaa     1020

ggaagtagtt cacaaaataa tagagttgct gaatgtcact gaacttaccc agaatgccct     1080

gattaatgat gaactagtgg agtggaagcg gagacagcag agcgcctgta ttggggggcc     1140

gcccaatgct tgcttggatc agctgcagaa ctggttcact atagttgcgg agagtctgca     1200

gcaagttcgg cagcagctta aaaagttgga ggaattggaa cagaaataca cctacgaaca     1260

tgaccctatc acaaaaaaca aacaagtgtt atgggaccgc accttcagtc ttttccagca     1320

gctcattcag agctcgtttg tggtggaaag acagccctgc atgccaacgc accctcagag     1380

gccgctggtc ttgaagacag gggtccagtt cactgtgaag ttgagactgt tggtgaaatt     1440

gcaagagctg aattataatt tgaaagtcaa agtcttattt gataaagatg tgaatgagag     1500

aaatacagta aaaggattta ggaagttcaa cattttgggc acgcacacaa aagtgatgaa     1560

catggaggag tccaccaatg gcagtctggc ggctgaattt cggcacctgc aattgaaaga     1620

acagaaaaat gctggcacca gaacgaatga gggtcctctc atcgttactg aagagcttca     1680

ctcccttagt tttgaaaccc aattgtgcca gcctggtttg gtaattgacc tcgagacgac     1740

ctctctgccc gttgtggtga tctccaacgt cagccagctc ccgagcggtt gggcctccat     1800

cctttggtac aacatgctgg tggcggaacc caggaatctg tccttcttcc tgactccacc     1860

atgtgcacga tgggctcagc tttcagaagt gctgagttgg cagttttctt ctgtcaccaa     1920

aagaggtctc aatgtggacc agctgaacat gttgggagag aagcttcttg gtcctaacgc     1980

cagccccgat ggtctcattc cgtggacgag gttttgtaag gaaaatataa atgataaaaa     2040

ttttcccttc tggctttgga ttgaaagcat cctagaactc attaaaaaac acctgctccc     2100

tctctggaat gatgggtgca tcatgggctt catcagcaag gagcgagagc gtgccctgtt     2160

gaaggaccag cagccgggga ccttcctgct gcggttcagt gagagctccc gggaaggggc     2220

catcacattc acatgggtgg agcggtccca gaacggaggc gaacctgact tccatgcggt     2280

tgaaccctac acgaagaaag aactttctgc tgttactttc cctgacatca ttcgcaatta     2340

caaagtcatg gctgctgaga atattcctga gaatcccctg aagtatctgt atccaaatat     2400

tgacaaagac catgcctttg gaaagtatta ctccaggcca aaggaagcac cagagccaat     2460

ggaacttgat ggccctaaag gaactggata tatcaagact gagttgattt ctgtgtctga     2520

agtgtaagtg aacacagaag agtgacatgt ttacaaacct caagccagcc ttgctcctgg     2580

ctggggcctg ttgaagatgc ttgtatttta cttttccatt gtaattgcta tcgccatcac     2640

agctgaactt gttgagatcc ccgtgttact gcctatcagc attttactac tttaaaaaaa     2700

aaaaaaaagc caaaaaccaa atttgtattt aaggtatata aattttccca aaactgatac     2760

cctttgaaaa agtataaata aaatgagcaa aagttgat                             2798


<210>  105
<211>  750
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val His Pro Ser Arg Leu Gln Thr Thr 
705                 710                 715                 720 


Asp Asn Leu Leu Pro Met Ser Pro Glu Glu Phe Asp Glu Val Ser Arg 
                725                 730                 735     


Ile Val Gly Ser Val Glu Phe Asp Ser Met Met Asn Thr Val 
            740                 745                 750 


<210>  106
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Ser Gln Trp Tyr Glu Leu Gln Gln Leu Asp Ser Lys Phe Leu Glu 
1               5                   10                  15      


Gln Val His Gln Leu Tyr Asp Asp Ser Phe Pro Met Glu Ile Arg Gln 
            20                  25                  30          


Tyr Leu Ala Gln Trp Leu Glu Lys Gln Asp Trp Glu His Ala Ala Asn 
        35                  40                  45              


Asp Val Ser Phe Ala Thr Ile Arg Phe His Asp Leu Leu Ser Gln Leu 
    50                  55                  60                  


Asp Asp Gln Tyr Ser Arg Phe Ser Leu Glu Asn Asn Phe Leu Leu Gln 
65                  70                  75                  80  


His Asn Ile Arg Lys Ser Lys Arg Asn Leu Gln Asp Asn Phe Gln Glu 
                85                  90                  95      


Asp Pro Ile Gln Met Ser Met Ile Ile Tyr Ser Cys Leu Lys Glu Glu 
            100                 105                 110         


Arg Lys Ile Leu Glu Asn Ala Gln Arg Phe Asn Gln Ala Gln Ser Gly 
        115                 120                 125             


Asn Ile Gln Ser Thr Val Met Leu Asp Lys Gln Lys Glu Leu Asp Ser 
    130                 135                 140                 


Lys Val Arg Asn Val Lys Asp Lys Val Met Cys Ile Glu His Glu Ile 
145                 150                 155                 160 


Lys Ser Leu Glu Asp Leu Gln Asp Glu Tyr Asp Phe Lys Cys Lys Thr 
                165                 170                 175     


Leu Gln Asn Arg Glu His Glu Thr Asn Gly Val Ala Lys Ser Asp Gln 
            180                 185                 190         


Lys Gln Glu Gln Leu Leu Leu Lys Lys Met Tyr Leu Met Leu Asp Asn 
        195                 200                 205             


Lys Arg Lys Glu Val Val His Lys Ile Ile Glu Leu Leu Asn Val Thr 
    210                 215                 220                 


Glu Leu Thr Gln Asn Ala Leu Ile Asn Asp Glu Leu Val Glu Trp Lys 
225                 230                 235                 240 


Arg Arg Gln Gln Ser Ala Cys Ile Gly Gly Pro Pro Asn Ala Cys Leu 
                245                 250                 255     


Asp Gln Leu Gln Asn Trp Phe Thr Ile Val Ala Glu Ser Leu Gln Gln 
            260                 265                 270         


Val Arg Gln Gln Leu Lys Lys Leu Glu Glu Leu Glu Gln Lys Tyr Thr 
        275                 280                 285             


Tyr Glu His Asp Pro Ile Thr Lys Asn Lys Gln Val Leu Trp Asp Arg 
    290                 295                 300                 


Thr Phe Ser Leu Phe Gln Gln Leu Ile Gln Ser Ser Phe Val Val Glu 
305                 310                 315                 320 


Arg Gln Pro Cys Met Pro Thr His Pro Gln Arg Pro Leu Val Leu Lys 
                325                 330                 335     


Thr Gly Val Gln Phe Thr Val Lys Leu Arg Leu Leu Val Lys Leu Gln 
            340                 345                 350         


Glu Leu Asn Tyr Asn Leu Lys Val Lys Val Leu Phe Asp Lys Asp Val 
        355                 360                 365             


Asn Glu Arg Asn Thr Val Lys Gly Phe Arg Lys Phe Asn Ile Leu Gly 
    370                 375                 380                 


Thr His Thr Lys Val Met Asn Met Glu Glu Ser Thr Asn Gly Ser Leu 
385                 390                 395                 400 


Ala Ala Glu Phe Arg His Leu Gln Leu Lys Glu Gln Lys Asn Ala Gly 
                405                 410                 415     


Thr Arg Thr Asn Glu Gly Pro Leu Ile Val Thr Glu Glu Leu His Ser 
            420                 425                 430         


Leu Ser Phe Glu Thr Gln Leu Cys Gln Pro Gly Leu Val Ile Asp Leu 
        435                 440                 445             


Glu Thr Thr Ser Leu Pro Val Val Val Ile Ser Asn Val Ser Gln Leu 
    450                 455                 460                 


Pro Ser Gly Trp Ala Ser Ile Leu Trp Tyr Asn Met Leu Val Ala Glu 
465                 470                 475                 480 


Pro Arg Asn Leu Ser Phe Phe Leu Thr Pro Pro Cys Ala Arg Trp Ala 
                485                 490                 495     


Gln Leu Ser Glu Val Leu Ser Trp Gln Phe Ser Ser Val Thr Lys Arg 
            500                 505                 510         


Gly Leu Asn Val Asp Gln Leu Asn Met Leu Gly Glu Lys Leu Leu Gly 
        515                 520                 525             


Pro Asn Ala Ser Pro Asp Gly Leu Ile Pro Trp Thr Arg Phe Cys Lys 
    530                 535                 540                 


Glu Asn Ile Asn Asp Lys Asn Phe Pro Phe Trp Leu Trp Ile Glu Ser 
545                 550                 555                 560 


Ile Leu Glu Leu Ile Lys Lys His Leu Leu Pro Leu Trp Asn Asp Gly 
                565                 570                 575     


Cys Ile Met Gly Phe Ile Ser Lys Glu Arg Glu Arg Ala Leu Leu Lys 
            580                 585                 590         


Asp Gln Gln Pro Gly Thr Phe Leu Leu Arg Phe Ser Glu Ser Ser Arg 
        595                 600                 605             


Glu Gly Ala Ile Thr Phe Thr Trp Val Glu Arg Ser Gln Asn Gly Gly 
    610                 615                 620                 


Glu Pro Asp Phe His Ala Val Glu Pro Tyr Thr Lys Lys Glu Leu Ser 
625                 630                 635                 640 


Ala Val Thr Phe Pro Asp Ile Ile Arg Asn Tyr Lys Val Met Ala Ala 
                645                 650                 655     


Glu Asn Ile Pro Glu Asn Pro Leu Lys Tyr Leu Tyr Pro Asn Ile Asp 
            660                 665                 670         


Lys Asp His Ala Phe Gly Lys Tyr Tyr Ser Arg Pro Lys Glu Ala Pro 
        675                 680                 685             


Glu Pro Met Glu Leu Asp Gly Pro Lys Gly Thr Gly Tyr Ile Lys Thr 
    690                 695                 700                 


Glu Leu Ile Ser Val Ser Glu Val 
705                 710         


<210>  107
<211>  1742
<212>  DNA
<213>  Homo sapiens

<400>  107
tctttgaagc ttcaaggctg ctgaataatt tccttctccc attttgtgcc tgcctagcta       60

tccagacaga gcagctaccc tcagctctag ctgatactac agacagtaca acagatcaag      120

aagtatggca gtgacaactc gtttgacatg gttgcacgaa aagatcctgc aaaatcattt      180

tggagggaag cggcttagcc ttctctataa gggtagtgtc catggattcc gtaatggagt      240

tttgcttgac agatgttgta atcaagggcc tactctaaca gtgatttata gtgaagatca      300

tattattgga gcatatgcag aagagagtta ccaggaagga aagtatgctt ccatcatcct      360

ttttgcactt caagatacta aaatttcaga atggaaacta ggactatgta caccagaaac      420

actgttttgt tgtgatgtta caaaatataa ctccccaact aatttccaga tagatggaag      480

aaatagaaaa gtgattatgg acttaaagac aatggaaaat cttggacttg ctcaaaattg      540

tactatctct attcaggatt atgaagtttt tcgatgcgaa gattcactgg atgaaagaaa      600

gataaaaggg gtcattgagc tcaggaagag cttactgtct gccttgagaa cttatgaacc      660

atatggatcc ctggttcaac aaatacgaat tctgctgctg ggtccaattg gagctgggaa      720

gtccagcttt ttcaactcag tgaggtctgt tttccaaggg catgtaacgc atcaggcttt      780

ggtgggcact aatacaactg ggatatctga gaagtatagg acatactcta ttagagacgg      840

gaaagatggc aaatacctgc cgtttattct gtgtgactca ctggggctga gtgagaaaga      900

aggcggcctg tgcagggatg acatattcta tatcttgaac ggtaacattc gtgatagata      960

ccagtttaat cccatggaat caatcaaatt aaatcatcat gactacattg attccccatc     1020

gctgaaggac agaattcatt gtgtggcatt tgtatttgat gccagctcta ttcaatactt     1080

ctcctctcag atgatagtaa agatcaaaag aattcgaagg gagttggtaa acgctggtgt     1140

ggtacatgtg gctttgctca ctcatgtgga tagcatggat ttgattacaa aaggtgacct     1200

tatagaaata gagagatgtg agcctgtgag gtccaagcta gaggaagtcc aaagaaaact     1260

tggatttgct ctttctgaca tctcggtggt tagcaattat tcctctgagt gggagctgga     1320

ccctgtaaag gatgttctaa ttctttctgc tctgagacga atgctatggg ctgcagatga     1380

cttcttagag gatttgcctt ttgagcaaat agggaatcta agggaggaaa ttatcaactg     1440

tgcacaagga aaaaaataga tatgtgaaag gttcacgtaa atttcctcac atcacagaag     1500

attaaaattc agaaaggaga aaacacagac caaagagaag tatctaagac caaagggatg     1560

tgttttatta atgtctagga tgaagaaatg catagaacat tgtagtactt gtaaataact     1620

agaaataaca tgatttagtc ataattgtga aaaataataa taatttttct tggatttatg     1680

ttctgtatct gtgaaaaaat aaatttctta taaaactcgg gtctaaaaaa aaaaaaaaaa     1740

aa                                                                    1742


<210>  108
<211>  444
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ala Val Thr Thr Arg Leu Thr Trp Leu His Glu Lys Ile Leu Gln 
1               5                   10                  15      


Asn His Phe Gly Gly Lys Arg Leu Ser Leu Leu Tyr Lys Gly Ser Val 
            20                  25                  30          


His Gly Phe Arg Asn Gly Val Leu Leu Asp Arg Cys Cys Asn Gln Gly 
        35                  40                  45              


Pro Thr Leu Thr Val Ile Tyr Ser Glu Asp His Ile Ile Gly Ala Tyr 
    50                  55                  60                  


Ala Glu Glu Ser Tyr Gln Glu Gly Lys Tyr Ala Ser Ile Ile Leu Phe 
65                  70                  75                  80  


Ala Leu Gln Asp Thr Lys Ile Ser Glu Trp Lys Leu Gly Leu Cys Thr 
                85                  90                  95      


Pro Glu Thr Leu Phe Cys Cys Asp Val Thr Lys Tyr Asn Ser Pro Thr 
            100                 105                 110         


Asn Phe Gln Ile Asp Gly Arg Asn Arg Lys Val Ile Met Asp Leu Lys 
        115                 120                 125             


Thr Met Glu Asn Leu Gly Leu Ala Gln Asn Cys Thr Ile Ser Ile Gln 
    130                 135                 140                 


Asp Tyr Glu Val Phe Arg Cys Glu Asp Ser Leu Asp Glu Arg Lys Ile 
145                 150                 155                 160 


Lys Gly Val Ile Glu Leu Arg Lys Ser Leu Leu Ser Ala Leu Arg Thr 
                165                 170                 175     


Tyr Glu Pro Tyr Gly Ser Leu Val Gln Gln Ile Arg Ile Leu Leu Leu 
            180                 185                 190         


Gly Pro Ile Gly Ala Gly Lys Ser Ser Phe Phe Asn Ser Val Arg Ser 
        195                 200                 205             


Val Phe Gln Gly His Val Thr His Gln Ala Leu Val Gly Thr Asn Thr 
    210                 215                 220                 


Thr Gly Ile Ser Glu Lys Tyr Arg Thr Tyr Ser Ile Arg Asp Gly Lys 
225                 230                 235                 240 


Asp Gly Lys Tyr Leu Pro Phe Ile Leu Cys Asp Ser Leu Gly Leu Ser 
                245                 250                 255     


Glu Lys Glu Gly Gly Leu Cys Arg Asp Asp Ile Phe Tyr Ile Leu Asn 
            260                 265                 270         


Gly Asn Ile Arg Asp Arg Tyr Gln Phe Asn Pro Met Glu Ser Ile Lys 
        275                 280                 285             


Leu Asn His His Asp Tyr Ile Asp Ser Pro Ser Leu Lys Asp Arg Ile 
    290                 295                 300                 


His Cys Val Ala Phe Val Phe Asp Ala Ser Ser Ile Gln Tyr Phe Ser 
305                 310                 315                 320 


Ser Gln Met Ile Val Lys Ile Lys Arg Ile Arg Arg Glu Leu Val Asn 
                325                 330                 335     


Ala Gly Val Val His Val Ala Leu Leu Thr His Val Asp Ser Met Asp 
            340                 345                 350         


Leu Ile Thr Lys Gly Asp Leu Ile Glu Ile Glu Arg Cys Glu Pro Val 
        355                 360                 365             


Arg Ser Lys Leu Glu Glu Val Gln Arg Lys Leu Gly Phe Ala Leu Ser 
    370                 375                 380                 


Asp Ile Ser Val Val Ser Asn Tyr Ser Ser Glu Trp Glu Leu Asp Pro 
385                 390                 395                 400 


Val Lys Asp Val Leu Ile Leu Ser Ala Leu Arg Arg Met Leu Trp Ala 
                405                 410                 415     


Ala Asp Asp Phe Leu Glu Asp Leu Pro Phe Glu Gln Ile Gly Asn Leu 
            420                 425                 430         


Arg Glu Glu Ile Ile Asn Cys Ala Gln Gly Lys Lys 
        435                 440                 


<210>  109
<211>  2808
<212>  DNA
<213>  Homo sapiens

<400>  109
gcggcggcgg cggcgcagtt tgctcatact ttgtgacttg cggtcacagt ggcattcagc       60

tccacacttg gtagaaccac aggcacgaca agcatagaaa catcctaaac aatcttcatc      120

gaggcatcga ggtccatccc aataaaaatc aggagaccct ggctatcata gaccttagtc      180

ttcgctggta tactcgctgt ctgtcaacca gcggttgact ttttttaagc cttctttttt      240

ctcttttacc agtttctgga gcaaattcag tttgccttcc tggatttgta aattgtaatg      300

acctcaaaac tttagcagtt cttccatctg actcaggttt gcttctctgg cggtcttcag      360

aatcaacatc cacacttccg tgattatctg cgtgcatttt ggacaaagct tccaaccagg      420

atacgggaag aagaaatggc tggtgatctt tcagcaggtt tcttcatgga ggaacttaat      480

acataccgtc agaagcaggg agtagtactt aaatatcaag aactgcctaa ttcaggacct      540

ccacatgata ggaggtttac atttcaagtt ataatagatg gaagagaatt tccagaaggt      600

gaaggtagat caaagaagga agcaaaaaat gccgcagcca aattagctgt tgagatactt      660

aataaggaaa agaaggcagt tagtccttta ttattgacaa caacgaattc ttcagaagga      720

ttatccatgg ggaattacat aggccttatc aatagaattg cccagaagaa aagactaact      780

gtaaattatg aacagtgtgc atcgggggtg catgggccag aaggatttca ttataaatgc      840

aaaatgggac agaaagaata tagtattggt acaggttcta ctaaacagga agcaaaacaa      900

ttggccgcta aacttgcata tcttcagata ttatcagaag aaacctcagt gaaatctgac      960

tacctgtcct ctggttcttt tgctactacg tgtgagtccc aaagcaactc tttagtgacc     1020

agcacactcg cttctgaatc atcatctgaa ggtgacttct cagcagatac atcagagata     1080

aattctaaca gtgacagttt aaacagttct tcgttgctta tgaatggtct cagaaataat     1140

caaaggaagg caaaaagatc tttggcaccc agatttgacc ttcctgacat gaaagaaaca     1200

aagtatactg tggacaagag gtttggcatg gattttaaag aaatagaatt aattggctca     1260

ggtggatttg gccaagtttt caaagcaaaa cacagaattg acggaaagac ttacgttatt     1320

aaacgtgtta aatataataa cgagaaggcg gagcgtgaag taaaagcatt ggcaaaactt     1380

gatcatgtaa atattgttca ctacaatggc tgttgggatg gatttgatta tgatcctgag     1440

accagtgatg attctcttga gagcagtgat tatgatcctg agaacagcaa aaatagttca     1500

aggtcaaaga ctaagtgcct tttcatccaa atggaattct gtgataaagg gaccttggaa     1560

caatggattg aaaaaagaag aggcgagaaa ctagacaaag ttttggcttt ggaactcttt     1620

gaacaaataa caaaaggggt ggattatata cattcaaaaa aattaattca tagagatctt     1680

aagccaagta atatattctt agtagataca aaacaagtaa agattggaga ctttggactt     1740

gtaacatctc tgaaaaatga tggaaagcga acaaggagta agggaacttt gcgatacatg     1800

agcccagaac agatttcttc gcaagactat ggaaaggaag tggacctcta cgctttgggg     1860

ctaattcttg ctgaacttct tcatgtatgt gacactgctt ttgaaacatc aaagtttttc     1920

acagacctac gggatggcat catctcagat atatttgata aaaaagaaaa aactcttcta     1980

cagaaattac tctcaaagaa acctgaggat cgacctaaca catctgaaat actaaggacc     2040

ttgactgtgt ggaagaaaag cccagagaaa aatgaacgac acacatgtta gagcccttct     2100

gaaaaagtat cctgcttctg atatgcagtt ttccttaaat tatctaaaat ctgctaggga     2160

atatcaatag atatttacct tttattttaa tgtttccttt aattttttac tatttttact     2220

aatctttctg cagaaacaga aaggttttct tctttttgct tcaaaaacat tcttacattt     2280

tactttttcc tggctcatct ctttattctt tttttttttt ttaaagacag agtctcgctc     2340

tgttgcccag gctggagtgc aatgacacag tcttggctca ctgcaacttc tgcctcttgg     2400

gttcaagtga ttctcctgcc tcagcctcct gagtagctgg attacaggca tgtgccaccc     2460

acccaactaa tttttgtgtt tttaataaag acagggtttc accatgttgg ccaggctggt     2520

ctcaaactcc tgacctcaag taatccacct gcctcggcct cccaaagtgc tgggattaca     2580

gggatgagcc accgcgccca gcctcatctc tttgttctaa agatggaaaa accaccccca     2640

aattttcttt ttatactatt aatgaatcaa tcaattcata tctatttatt aaatttctac     2700

cgcttttagg ccaaaaaaat gtaagatcgt tctctgcctc acatagctta caagccagct     2760

ggagaaatat ggtactcatt aaaaaaaaaa aaaaagtgat gtacaacc                  2808


<210>  110
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Ala Gly Asp Leu Ser Ala Gly Phe Phe Met Glu Glu Leu Asn Thr 
1               5                   10                  15      


Tyr Arg Gln Lys Gln Gly Val Val Leu Lys Tyr Gln Glu Leu Pro Asn 
            20                  25                  30          


Ser Gly Pro Pro His Asp Arg Arg Phe Thr Phe Gln Val Ile Ile Asp 
        35                  40                  45              


Gly Arg Glu Phe Pro Glu Gly Glu Gly Arg Ser Lys Lys Glu Ala Lys 
    50                  55                  60                  


Asn Ala Ala Ala Lys Leu Ala Val Glu Ile Leu Asn Lys Glu Lys Lys 
65                  70                  75                  80  


Ala Val Ser Pro Leu Leu Leu Thr Thr Thr Asn Ser Ser Glu Gly Leu 
                85                  90                  95      


Ser Met Gly Asn Tyr Ile Gly Leu Ile Asn Arg Ile Ala Gln Lys Lys 
            100                 105                 110         


Arg Leu Thr Val Asn Tyr Glu Gln Cys Ala Ser Gly Val His Gly Pro 
        115                 120                 125             


Glu Gly Phe His Tyr Lys Cys Lys Met Gly Gln Lys Glu Tyr Ser Ile 
    130                 135                 140                 


Gly Thr Gly Ser Thr Lys Gln Glu Ala Lys Gln Leu Ala Ala Lys Leu 
145                 150                 155                 160 


Ala Tyr Leu Gln Ile Leu Ser Glu Glu Thr Ser Val Lys Ser Asp Tyr 
                165                 170                 175     


Leu Ser Ser Gly Ser Phe Ala Thr Thr Cys Glu Ser Gln Ser Asn Ser 
            180                 185                 190         


Leu Val Thr Ser Thr Leu Ala Ser Glu Ser Ser Ser Glu Gly Asp Phe 
        195                 200                 205             


Ser Ala Asp Thr Ser Glu Ile Asn Ser Asn Ser Asp Ser Leu Asn Ser 
    210                 215                 220                 


Ser Ser Leu Leu Met Asn Gly Leu Arg Asn Asn Gln Arg Lys Ala Lys 
225                 230                 235                 240 


Arg Ser Leu Ala Pro Arg Phe Asp Leu Pro Asp Met Lys Glu Thr Lys 
                245                 250                 255     


Tyr Thr Val Asp Lys Arg Phe Gly Met Asp Phe Lys Glu Ile Glu Leu 
            260                 265                 270         


Ile Gly Ser Gly Gly Phe Gly Gln Val Phe Lys Ala Lys His Arg Ile 
        275                 280                 285             


Asp Gly Lys Thr Tyr Val Ile Lys Arg Val Lys Tyr Asn Asn Glu Lys 
    290                 295                 300                 


Ala Glu Arg Glu Val Lys Ala Leu Ala Lys Leu Asp His Val Asn Ile 
305                 310                 315                 320 


Val His Tyr Asn Gly Cys Trp Asp Gly Phe Asp Tyr Asp Pro Glu Thr 
                325                 330                 335     


Ser Asp Asp Ser Leu Glu Ser Ser Asp Tyr Asp Pro Glu Asn Ser Lys 
            340                 345                 350         


Asn Ser Ser Arg Ser Lys Thr Lys Cys Leu Phe Ile Gln Met Glu Phe 
        355                 360                 365             


Cys Asp Lys Gly Thr Leu Glu Gln Trp Ile Glu Lys Arg Arg Gly Glu 
    370                 375                 380                 


Lys Leu Asp Lys Val Leu Ala Leu Glu Leu Phe Glu Gln Ile Thr Lys 
385                 390                 395                 400 


Gly Val Asp Tyr Ile His Ser Lys Lys Leu Ile His Arg Asp Leu Lys 
                405                 410                 415     


Pro Ser Asn Ile Phe Leu Val Asp Thr Lys Gln Val Lys Ile Gly Asp 
            420                 425                 430         


Phe Gly Leu Val Thr Ser Leu Lys Asn Asp Gly Lys Arg Thr Arg Ser 
        435                 440                 445             


Lys Gly Thr Leu Arg Tyr Met Ser Pro Glu Gln Ile Ser Ser Gln Asp 
    450                 455                 460                 


Tyr Gly Lys Glu Val Asp Leu Tyr Ala Leu Gly Leu Ile Leu Ala Glu 
465                 470                 475                 480 


Leu Leu His Val Cys Asp Thr Ala Phe Glu Thr Ser Lys Phe Phe Thr 
                485                 490                 495     


Asp Leu Arg Asp Gly Ile Ile Ser Asp Ile Phe Asp Lys Lys Glu Lys 
            500                 505                 510         


Thr Leu Leu Gln Lys Leu Leu Ser Lys Lys Pro Glu Asp Arg Pro Asn 
        515                 520                 525             


Thr Ser Glu Ile Leu Arg Thr Leu Thr Val Trp Lys Lys Ser Pro Glu 
    530                 535                 540                 


Lys Asn Glu Arg His Thr Cys 
545                 550     


<210>  111
<211>  2613
<212>  DNA
<213>  Homo sapiens

<400>  111
agtttcagtt tccatttctg atttctgctc tctgcgctga gcacagcggc accaggctga       60

gctaagcagg gccgccttgg gcaggcctac gtggtggtgc aggcgagacc caggctgggc      120

aaggcgcagt ttcagtttcc atcttgggtc tctgagctga gcagagtggc accaggctga      180

gttaagtggg actgccctgg gcagacctac ctactagagc agaatggagc ttcggtccta      240

ccaatgggag gtgatcatgc ctgccctgga gggcaagaat atcatcatct ggctgcccac      300

gggtgccggg aagacccggg cggctgctta tgtggccaag cggcacctag agactgtgga      360

tggagccaag gtggttgtat tggtcaacag ggtgcacctg gtgacccagc atggtgaaga      420

gttcaggcgc atgctggatg gacgctggac cgtgacaacc ctgagtgggg acatgggacc      480

acgtgctggc tttggccacc tggcccggtg ccatgacctg ctcatctgca cagcagagct      540

tctgcagatg gcactgacca gccccgagga ggaggagcac gtggagctca ctgtcttctc      600

cctgatcgtg gtggatgagt gccaccacac gcacaaggac accgtctaca acgtcatcat      660

gagccagtac ctagaactta aactccagag ggcacagccg ctaccccagg tgctgggtct      720

cacagcctcc ccaggcactg gcggggcctc caaactcgat ggggccatca accacgtcct      780

gcagctctgt gccaacttgg acacgtggtg catcatgtca ccccagaact gctgccccca      840

gctgcaggag cacagccaac agccttgcaa acagtacaac ctctgccaca ggcgcagcca      900

ggatccgttt ggggacttgc tgaagaagct catggaccaa atccatgacc acctggagat      960

gcctgagttg agccggaaat ttgggacgca aatgtatgag cagcaggtgg tgaagctgag     1020

tgaggctgcg gctttggctg ggcttcagga gcaacgggtg tatgcgcttc acctgaggcg     1080

ctacaatgac gcgctgctca tccatgacac cgtccgcgcc gtggatgcct tggctgcgct     1140

gcaggatttc tatcacaggg agcacgtcac taaaacccag atcctgtgtg ccgagcgccg     1200

gctgctggcc ctgttcgatg accgcaagaa tgagctggcc cacttggcaa ctcatggccc     1260

agagaatcca aaactggaga tgctggaaaa gatcctgcaa aggcagttca gtagctctaa     1320

cagccctcgg ggtatcatct tcacccgcac ccgccaaagc gcacactccc tcctgctctg     1380

gctccagcag caacagggcc tgcagactgt ggacatccgg gcccagctac tgattggggc     1440

tgggaacagc agccagagca cccacatgac ccagagggac cagcaagaag tgatccagaa     1500

gttccaagat ggaaccctga accttctggt ggccacgagt gtggcggagg aggggctgga     1560

catcccacat tgcaatgtgg tggtgcgtta tgggctcttg accaatgaaa tctccatggt     1620

ccaggccagg ggccgtgcct gggccgatca gagtgtatac gcgtttgtag caactgaagg     1680

tagccgggag ctgaagcggg agctgatcaa cgaggcgctg gagacgctaa tggagcaggc     1740

agtggctgct gtgcagaaaa tggaccaggc cgagtaccag gccaagatcc gggatctgca     1800

gcaggcagcc ttgaccaagc gggcggccca ggcagcccag cgggagaacc agcggcagca     1860

gttcccagtg gagcacgtgc agctactctg catcaactgc atggtggctg tgggccatgg     1920

cagcgacctg cggaaggtgg agggcaccca ccatgtcaat gtgaacccca acttctcgaa     1980

ctactataat gtctccaggg atcctgtggt catcaacaaa gtcttcaagg actggaagcc     2040

tgggggtgtc atcagctgca ggaactgtgg ggaggtctgg ggtctgcaga tgatctacaa     2100

gtcagtgaag ctgccagtgc tcaaagtccg cagcatgctg ctggagaccc ctcaggggcg     2160

gatccaggcc aaaaagtggt cccgcgtgcc cttctccgtg cctgactttg acttcctgca     2220

gcattgtgcc gagaacttgt cggacctctc cctggactga ccacctcatt gctgcagtgc     2280

ccggtttggg ctgtaggggg cgggagagtc tgcagcagac tccaggcccc tccttcctga     2340

atcatcagct gtgggcatca ggcccaccag ccacacagga gtcctgggca ccctggctta     2400

ggctcccgca atgggaaaac aaccggaggg ccagagctta gtccagacct accttgtacg     2460

cacatagaca ttttcatatg cactggatgg agttagggaa actgaggcaa aagaatttgc     2520

catactgtac tcagaatcac gacattcctt ccctaccaag gccacttcta ttttttgagg     2580

ctcctcataa aaataaatga aaaaatggga tag                                  2613


<210>  112
<211>  678
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Glu Leu Arg Ser Tyr Gln Trp Glu Val Ile Met Pro Ala Leu Glu 
1               5                   10                  15      


Gly Lys Asn Ile Ile Ile Trp Leu Pro Thr Gly Ala Gly Lys Thr Arg 
            20                  25                  30          


Ala Ala Ala Tyr Val Ala Lys Arg His Leu Glu Thr Val Asp Gly Ala 
        35                  40                  45              


Lys Val Val Val Leu Val Asn Arg Val His Leu Val Thr Gln His Gly 
    50                  55                  60                  


Glu Glu Phe Arg Arg Met Leu Asp Gly Arg Trp Thr Val Thr Thr Leu 
65                  70                  75                  80  


Ser Gly Asp Met Gly Pro Arg Ala Gly Phe Gly His Leu Ala Arg Cys 
                85                  90                  95      


His Asp Leu Leu Ile Cys Thr Ala Glu Leu Leu Gln Met Ala Leu Thr 
            100                 105                 110         


Ser Pro Glu Glu Glu Glu His Val Glu Leu Thr Val Phe Ser Leu Ile 
        115                 120                 125             


Val Val Asp Glu Cys His His Thr His Lys Asp Thr Val Tyr Asn Val 
    130                 135                 140                 


Ile Met Ser Gln Tyr Leu Glu Leu Lys Leu Gln Arg Ala Gln Pro Leu 
145                 150                 155                 160 


Pro Gln Val Leu Gly Leu Thr Ala Ser Pro Gly Thr Gly Gly Ala Ser 
                165                 170                 175     


Lys Leu Asp Gly Ala Ile Asn His Val Leu Gln Leu Cys Ala Asn Leu 
            180                 185                 190         


Asp Thr Trp Cys Ile Met Ser Pro Gln Asn Cys Cys Pro Gln Leu Gln 
        195                 200                 205             


Glu His Ser Gln Gln Pro Cys Lys Gln Tyr Asn Leu Cys His Arg Arg 
    210                 215                 220                 


Ser Gln Asp Pro Phe Gly Asp Leu Leu Lys Lys Leu Met Asp Gln Ile 
225                 230                 235                 240 


His Asp His Leu Glu Met Pro Glu Leu Ser Arg Lys Phe Gly Thr Gln 
                245                 250                 255     


Met Tyr Glu Gln Gln Val Val Lys Leu Ser Glu Ala Ala Ala Leu Ala 
            260                 265                 270         


Gly Leu Gln Glu Gln Arg Val Tyr Ala Leu His Leu Arg Arg Tyr Asn 
        275                 280                 285             


Asp Ala Leu Leu Ile His Asp Thr Val Arg Ala Val Asp Ala Leu Ala 
    290                 295                 300                 


Ala Leu Gln Asp Phe Tyr His Arg Glu His Val Thr Lys Thr Gln Ile 
305                 310                 315                 320 


Leu Cys Ala Glu Arg Arg Leu Leu Ala Leu Phe Asp Asp Arg Lys Asn 
                325                 330                 335     


Glu Leu Ala His Leu Ala Thr His Gly Pro Glu Asn Pro Lys Leu Glu 
            340                 345                 350         


Met Leu Glu Lys Ile Leu Gln Arg Gln Phe Ser Ser Ser Asn Ser Pro 
        355                 360                 365             


Arg Gly Ile Ile Phe Thr Arg Thr Arg Gln Ser Ala His Ser Leu Leu 
    370                 375                 380                 


Leu Trp Leu Gln Gln Gln Gln Gly Leu Gln Thr Val Asp Ile Arg Ala 
385                 390                 395                 400 


Gln Leu Leu Ile Gly Ala Gly Asn Ser Ser Gln Ser Thr His Met Thr 
                405                 410                 415     


Gln Arg Asp Gln Gln Glu Val Ile Gln Lys Phe Gln Asp Gly Thr Leu 
            420                 425                 430         


Asn Leu Leu Val Ala Thr Ser Val Ala Glu Glu Gly Leu Asp Ile Pro 
        435                 440                 445             


His Cys Asn Val Val Val Arg Tyr Gly Leu Leu Thr Asn Glu Ile Ser 
    450                 455                 460                 


Met Val Gln Ala Arg Gly Arg Ala Arg Ala Asp Gln Ser Val Tyr Ala 
465                 470                 475                 480 


Phe Val Ala Thr Glu Gly Ser Arg Glu Leu Lys Arg Glu Leu Ile Asn 
                485                 490                 495     


Glu Ala Leu Glu Thr Leu Met Glu Gln Ala Val Ala Ala Val Gln Lys 
            500                 505                 510         


Met Asp Gln Ala Glu Tyr Gln Ala Lys Ile Arg Asp Leu Gln Gln Ala 
        515                 520                 525             


Ala Leu Thr Lys Arg Ala Ala Gln Ala Ala Gln Arg Glu Asn Gln Arg 
    530                 535                 540                 


Gln Gln Phe Pro Val Glu His Val Gln Leu Leu Cys Ile Asn Cys Met 
545                 550                 555                 560 


Val Ala Val Gly His Gly Ser Asp Leu Arg Lys Val Glu Gly Thr His 
                565                 570                 575     


His Val Asn Val Asn Pro Asn Phe Ser Asn Tyr Tyr Asn Val Ser Arg 
            580                 585                 590         


Asp Pro Val Val Ile Asn Lys Val Phe Lys Asp Trp Lys Pro Gly Gly 
        595                 600                 605             


Val Ile Ser Cys Arg Asn Cys Gly Glu Val Trp Gly Leu Gln Met Ile 
    610                 615                 620                 


Tyr Lys Ser Val Lys Leu Pro Val Leu Lys Val Arg Ser Met Leu Leu 
625                 630                 635                 640 


Glu Thr Pro Gln Gly Arg Ile Gln Ala Lys Lys Trp Ser Arg Val Pro 
                645                 650                 655     


Phe Ser Val Pro Asp Phe Asp Phe Leu Gln His Cys Ala Glu Asn Leu 
            660                 665                 670         


Ser Asp Leu Ser Leu Asp 
        675             


