                               SEQUENCE LISTING

<110> NOVARTIS AG
 
<120> METHODS OF SELECTIVELY TREATING ASTHMA USING IL-13 ANTAGONISTS

<130> PAT056217-WO-PCT

<140>
<141>

<150> 61/978,604
<151> 2014-04-11

<160> 67    

<170> PatentIn version 3.5

<210> 1
<211> 146
<212> PRT
<213> Homo sapiens

<400> 1
Met His Pro Leu Leu Asn Pro Leu Leu Leu Ala Leu Gly Leu Met Ala 
1               5                   10                  15      


Leu Leu Leu Thr Thr Val Ile Ala Leu Thr Cys Leu Gly Gly Phe Ala 
            20                  25                  30          


Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
        35                  40                  45              


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
    50                  55                  60                  


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
65                  70                  75                  80  


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
                85                  90                  95      


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
            100                 105                 110         


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
        115                 120                 125             


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Arg 
    130                 135                 140                 


Phe Asn 
145     


<210> 2
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 2
Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210> 3
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 3
Ile Trp Tyr Asp Gly Ser Asn 
1               5           


<210> 4
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 4
Ala Arg Leu Trp Phe Gly Asp Leu Asp 
1               5                   


<210> 5
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 5
Ser Tyr Gly Met His 
1               5   


<210> 6
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 6
Ile Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 7
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 7
Leu Trp Phe Gly Asp Leu Asp Ala Phe Asp Ile 
1               5                   10      


<210> 8
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 8
Gln Ser Val Ser Ser Tyr 
1               5       


<210> 9
<211> 2
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Asp Ala 
1       


<210> 10
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 10
Gln Gln Arg Ser Ser Trp Pro Pro Val 
1               5                   


<210> 11
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Arg Ala Gly Gln Ser Val Ser Ser Tyr Leu Val 
1               5                   10      


<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 12
Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210> 13
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 13
Gln Gln Arg Ser Ser Trp Pro Pro Val Tyr Thr 
1               5                   10      


<210> 14
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ile Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Trp Phe Gly Asp Leu Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr 
        115         


<210> 15
<211> 351
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> CDS
<222> (1)..(351)

<400> 15
gaa gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag cct ggg agg         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg           
1               5                   10                  15                

tcc ctg aga ctc tcc tgt gca gcg tct gga ttc acc ttc agt agc tat         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr           
            20                  25                  30                    

ggc atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg gag tgg gtg        144
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

gca att ata tgg tat gat gga agt aat aaa tac tat gcg gac tcc gtg        192
Ala Ile Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val           
    50                  55                  60                            

aag ggc cga ttc acc atc tcc aga gac aat tcc aag aac acg ctg tat        240
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr           
65                  70                  75                  80            

ctg caa atg aac agc ctg aga gcc gag gac acg gct gtg tat tac tgt        288
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gcg agg cta tgg ttc ggg gac tta gat gct ttt gat atc tgg ggc caa        336
Ala Arg Leu Trp Phe Gly Asp Leu Asp Ala Phe Asp Ile Trp Gly Gln           
            100                 105                 110                   

ggg aca atg gtc acc                                                    351
Gly Thr Met Val Thr                                                       
        115                                                               


<210> 16
<211> 104
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 16
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Ile Leu Ser Cys Arg Ala Gly Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Trp Pro Pro 
                85                  90                  95      


Val Tyr Thr Phe Gly Gln Gly Thr 
            100                 


<210> 17
<211> 312
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> CDS
<222> (1)..(312)

<400> 17
gaa att gtg ttg acg cag tct cca gcc acc ctg tct ttg tct cca ggg         48
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly           
1               5                   10                  15                

gaa aga gcc atc ctc tcc tgc agg gcc ggt cag agt gtt agc agt tac         96
Glu Arg Ala Ile Leu Ser Cys Arg Ala Gly Gln Ser Val Ser Ser Tyr           
            20                  25                  30                    

tta gtc tgg tac caa cag aaa cct ggc cag gct ccc agg ctc ctc atc        144
Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile           
        35                  40                  45                        

tat gat gca tcc aac agg gcc act ggc atc cca gcc agg ttc agt ggc        192
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly           
    50                  55                  60                            

agt ggg tct ggg aca gac ttc act ctc acc atc agc agc cta gag cct        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro           
65                  70                  75                  80            

gaa gat ttt gca gtt tat tac tgt cag cag cgc agc agc tgg cct ccg        288
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Ser Trp Pro Pro           
                85                  90                  95                

gtg tac act ttt ggc cag ggg acc                                        312
Val Tyr Thr Phe Gly Gln Gly Thr                                           
            100                                                           


<210> 18
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 18
Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr 
1               5                   10                  15      


Gly Thr Arg Cys Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser 
            20                  25                  30          


Leu Ser Pro Gly Glu Arg Ala Ile Leu Ser Cys Arg Ala Gly Gln Ser 
        35                  40                  45              


Val Ser Ser Tyr Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
    50                  55                  60                  


Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser 
            100                 105                 110         


Ser Trp Pro Pro Val Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210> 19
<211> 711
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> CDS
<222> (1)..(711)

<400> 19
atg agt gtg ctc act cag gtc ctg gcg ttg ctg ctg ctg tgg ctt aca         48
Met Ser Val Leu Thr Gln Val Leu Ala Leu Leu Leu Leu Trp Leu Thr           
1               5                   10                  15                

ggt acg cgt tgt gaa att gtg ttg acg cag tct cca gcc acc ctg tct         96
Gly Thr Arg Cys Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser           
            20                  25                  30                    

ttg tct cca ggg gaa aga gcc atc ctc tcc tgc agg gcc ggt cag agt        144
Leu Ser Pro Gly Glu Arg Ala Ile Leu Ser Cys Arg Ala Gly Gln Ser           
        35                  40                  45                        

gtt agc agt tac tta gtc tgg tac caa cag aaa cct ggc cag gct ccc        192
Val Ser Ser Tyr Leu Val Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro           
    50                  55                  60                            

agg ctc ctc atc tat gat gca tcc aac agg gcc act ggc atc cca gcc        240
Arg Leu Leu Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala           
65                  70                  75                  80            

agg ttc agt ggc agt ggg tct ggg aca gac ttc act ctc acc atc agc        288
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser           
                85                  90                  95                

agc cta gag cct gaa gat ttt gca gtt tat tac tgt cag cag cgc agc        336
Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser           
            100                 105                 110                   

agc tgg cct ccg gtg tac act ttt ggc cag ggg acc aag ctt gaa atc        384
Ser Trp Pro Pro Val Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile           
        115                 120                 125                       

aaa cga act gtg gct gca cca tct gtc ttc atc ttc ccg cca tct gat        432
Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp           
    130                 135                 140                           

gag cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg aat aac        480
Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn           
145                 150                 155                 160           

ttc tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac gcc ctc        528
Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu           
                165                 170                 175               

caa tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc aag gac        576
Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp           
            180                 185                 190                   

agc acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca gac tac        624
Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr           
        195                 200                 205                       

gag aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc ctg agc        672
Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser           
    210                 215                 220                           

tcg ccc gtc aca aag agc ttc aac agg gga gag tgt tag                    711
Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                           
225                 230                 235                               


<210> 20
<211> 469
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 20
Met Ala Trp Val Trp Thr Leu Pro Phe Leu Met Ala Ala Ala Gln Ser 
1               5                   10                  15      


Val Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln 
            20                  25                  30          


Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Ile Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Leu Trp Phe Gly Asp Leu Asp Ala Phe Asp Ile 
        115                 120                 125             


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210> 21
<211> 1410
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> CDS
<222> (1)..(1410)

<400> 21
atg gct tgg gtg tgg acc ttg cca ttc ctg atg gca gct gcc caa agt         48
Met Ala Trp Val Trp Thr Leu Pro Phe Leu Met Ala Ala Ala Gln Ser           
1               5                   10                  15                

gtc cag gca gaa gtg cag ctg gtg gag tct ggg gga ggc gtg gtc cag         96
Val Gln Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln           
            20                  25                  30                    

cct ggg agg tcc ctg aga ctc tcc tgt gca gcg tct gga ttc acc ttc        144
Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe           
        35                  40                  45                        

agt agc tat ggc atg cac tgg gtc cgc cag gct cca ggc aag ggg ctg        192
Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu           
    50                  55                  60                            

gag tgg gtg gca att ata tgg tat gat gga agt aat aaa tac tat gcg        240
Glu Trp Val Ala Ile Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala           
65                  70                  75                  80            

gac tcc gtg aag ggc cga ttc acc atc tcc aga gac aat tcc aag aac        288
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn           
                85                  90                  95                

acg ctg tat ctg caa atg aac agc ctg aga gcc gag gac acg gct gtg        336
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val           
            100                 105                 110                   

tat tac tgt gcg agg cta tgg ttc ggg gac tta gat gct ttt gat atc        384
Tyr Tyr Cys Ala Arg Leu Trp Phe Gly Asp Leu Asp Ala Phe Asp Ile           
        115                 120                 125                       

tgg ggc caa ggg aca atg gtc acc gtc tcc tca gcc tcc acc aag ggc        432
Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly           
    130                 135                 140                           

cca tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg ggc        480
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly           
145                 150                 155                 160           

aca gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg        528
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val           
                165                 170                 175               

acg gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc ttc        576
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe           
            180                 185                 190                   

ccg gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtc gtg        624
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val           
        195                 200                 205                       

acc gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac gtg        672
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val           
    210                 215                 220                           

aat cac aag ccc agc aac acc aag gtg gac aag aga gtt gag ccc aaa        720
Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys           
225                 230                 235                 240           

tct tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa ctc        768
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu           
                245                 250                 255               

ctg ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc        816
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr           
            260                 265                 270                   

ctc atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg        864
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val           
        275                 280                 285                       

agc cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg        912
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val           
    290                 295                 300                           

gag gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc        960
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser           
305                 310                 315                 320           

acg tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg       1008
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu           
                325                 330                 335               

aat ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc       1056
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala           
            340                 345                 350                   

ccc atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca       1104
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro           
        355                 360                 365                       

cag gtg tac acc ctg ccc cca tcc cgg gag gag atg acc aag aac cag       1152
Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln           
    370                 375                 380                           

gtc agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc       1200
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala           
385                 390                 395                 400           

gtg gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg       1248
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr           
                405                 410                 415               

cct ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tat agc aag ctc       1296
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu           
            420                 425                 430                   

acc gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc       1344
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser           
        435                 440                 445                       

gtg atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc       1392
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser           
    450                 455                 460                           

ctg tcc ccg ggt aaa tga                                               1410
Leu Ser Pro Gly Lys                                                       
465                                                                       


<210> 22
<211> 51
<212> DNA
<213> Homo sapiens

<400> 22
gaaggttggc aggccaggga caacaycgtc tgccaagcca tggcagtaga c                51


<210> 23
<211> 51
<212> DNA
<213> Homo sapiens

<400> 23
taaggtattt ttgttatagc agcctrtatg gactaagctg acttgtaacg t                51


<210> 24
<211> 51
<212> DNA
<213> Homo sapiens

<400> 24
ctgtgtctgc agagcccaca cgtgtrtccc tgagaacaac ggaggcgcgg g                51


<210> 25
<211> 51
<212> DNA
<213> Homo sapiens

<400> 25
accccaggtc ccatatgtcc agagaktgtc cctccaatgg gaatgtgagg a                51


<210> 26
<211> 51
<212> DNA
<213> Homo sapiens

<400> 26
agggatgact tccaggaggg aagggmgggc attgtggccc ggctaacaga g                51


<210> 27
<211> 51
<212> DNA
<213> Homo sapiens

<400> 27
gtctcggccc ccaccagtgg ctatcrggag tttgtacatg cggtggagca g                51


<210> 28
<211> 51
<212> DNA
<213> Homo sapiens

<400> 28
gcaacagagg acatgaaaaa ttgctrtgac taaagcaggg acaatttgct g                51


<210> 29
<211> 51
<212> DNA
<213> Homo sapiens

<400> 29
cttgtatggg gaacccaaac ccagayggca agtttcttaa cctcttgcat c                51


<210> 30
<211> 51
<212> DNA
<213> Homo sapiens

<400> 30
gcttatgtca tcctgacacc tacgcrgatg tcggctcgaa tccactttgc c                51


<210> 31
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala 
1               5                   10                  15  


<210> 32
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe 
1               5                   10                  15  


<210> 33
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 33
Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala 
1               5                   10          


<210> 34
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 34
Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu 
1               5                   10                  15      


Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly 
            20                  25                  30          


Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
        35                  40                  45              


Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr 
    50                  55                  60                  


Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln 
65                  70                  75                  80  


Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
                85                  90                  95      


Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Arg 
            100                 105                 110         


Phe Asn 
        


<210> 35
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Ser Pro Gly Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile 
1               5                   10                  15  


<210> 36
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Pro Val Pro Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu Glu Leu 
1               5                   10                  15  


<210> 37
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Pro Ser Thr Ala Leu Arg Glu Leu Ile Glu Glu Leu Val Asn Ile 
1               5                   10                  15  


<210> 38
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 38
Ala Leu Arg Glu Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn 
1               5                   10                  15  


<210> 39
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Glu Leu Ile Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala 
1               5                   10                  15  


<210> 40
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Glu Glu Leu Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys 
1               5                   10                  15  


<210> 41
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
Val Asn Ile Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser 
1               5                   10                  15  


<210> 42
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Thr Gln Asn Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp 
1               5                   10                  15  


<210> 43
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Gln Lys Ala Pro Leu Cys Asn Gly Ser Met Val Trp Ser Ile Asn 
1               5                   10                  15  


<210> 44
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Pro Leu Cys Asn Gly Ser Met Val Trp Ser Ile Asn Leu Thr Ala 
1               5                   10                  15  


<210> 45
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 45
Asn Gly Ser Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr 
1               5                   10                  15  


<210> 46
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Met Val Trp Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala 
1               5                   10                  15  


<210> 47
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 47
Ser Ile Asn Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu Glu Ser 
1               5                   10                  15  


<210> 48
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 48
Leu Thr Ala Gly Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn 
1               5                   10                  15  


<210> 49
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Gly Met Tyr Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly 
1               5                   10                  15  


<210> 50
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 50
Cys Ala Ala Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala 
1               5                   10                  15  


<210> 51
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 51
Leu Glu Ser Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys 
1               5                   10                  15  


<210> 52
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Leu Ile Asn Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln Arg 
1               5                   10                  15  


<210> 53
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 53
Val Ser Gly Cys Ser Ala Ile Glu Lys Thr Gln Arg Met Leu Ser 
1               5                   10                  15  


<210> 54
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 54
Cys Ser Ala Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys 
1               5                   10                  15  


<210> 55
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 55
Ile Glu Lys Thr Gln Arg Met Leu Ser Gly Phe Cys Pro His Lys 
1               5                   10                  15  


<210> 56
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 56
Gly Phe Cys Pro His Lys Val Ser Ala Gly Gln Phe Ser Ser Leu 
1               5                   10                  15  


<210> 57
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 57
Pro His Lys Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg 
1               5                   10                  15  


<210> 58
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 58
Val Ser Ala Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys 
1               5                   10                  15  


<210> 59
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 59
Gly Gln Phe Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val 
1               5                   10                  15  


<210> 60
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 60
Ser Ser Leu His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe 
1               5                   10                  15  


<210> 61
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 61
His Val Arg Asp Thr Lys Ile Glu Val Ala Gln Phe Val Lys Asp 
1               5                   10                  15  


<210> 62
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 62
Asp Thr Lys Ile Glu Val Ala Gln Phe Val Lys Asp Leu Leu Leu 
1               5                   10                  15  


<210> 63
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 63
Ile Glu Val Ala Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys 
1               5                   10                  15  


<210> 64
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 64
Ala Gln Phe Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe 
1               5                   10                  15  


<210> 65
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 65
Val Lys Asp Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly 
1               5                   10                  15  


<210> 66
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 66
Leu Leu Leu His Leu Lys Lys Leu Phe Arg Glu Gly Arg Phe Asn 
1               5                   10                  15  


<210> 67
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 67
Phe Cys Pro His Lys Val 
1               5  



