               SEQUENCE LISTING

<110> TRANSGENE S.A.

<120> Poxviral oncolytic vectors

<130> Y1411 PCT S3

<150> US14/249,713
<151> 2014-04-10

<160> 18

<170> BiSSAP 1.2

<210> 1
<211> 373
<212> PRT
<213> Artificial Sequence

<220> 
<223> derived from Saccharomyces cerevisiae

<400> 1
Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      
Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          
Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              
Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  
Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  
Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      
Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         
Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             
Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 
Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu Ala Ser 
145                 150                 155                 160 
Glu Pro Phe Lys Asn Val Tyr Leu Leu Pro Gln Thr Asn Gln Leu Leu 
                165                 170                 175     
Gly Leu Tyr Thr Ile Ile Arg Asn Lys Asn Thr Thr Arg Pro Asp Phe 
            180                 185                 190         
Ile Phe Tyr Ser Asp Arg Ile Ile Arg Leu Leu Val Glu Glu Gly Leu 
        195                 200                 205             
Asn His Leu Pro Val Gln Lys Gln Ile Val Glu Thr Asp Thr Asn Glu 
    210                 215                 220                 
Asn Phe Glu Gly Val Ser Phe Met Gly Lys Ile Cys Gly Val Ser Ile 
225                 230                 235                 240 
Val Arg Ala Gly Glu Ser Met Glu Gln Gly Leu Arg Asp Cys Cys Arg 
                245                 250                 255     
Ser Val Arg Ile Gly Lys Ile Leu Ile Gln Arg Asp Glu Glu Thr Ala 
            260                 265                 270         
Leu Pro Lys Leu Phe Tyr Glu Lys Leu Pro Glu Asp Ile Ser Glu Arg 
        275                 280                 285             
Tyr Val Phe Leu Leu Asp Pro Met Leu Ala Thr Gly Gly Ser Ala Ile 
    290                 295                 300                 
Met Ala Thr Glu Val Leu Ile Lys Arg Gly Val Lys Pro Glu Arg Ile 
305                 310                 315                 320 
Tyr Phe Leu Asn Leu Ile Cys Ser Lys Glu Gly Ile Glu Lys Tyr His 
                325                 330                 335     
Ala Ala Phe Pro Glu Val Arg Ile Val Thr Gly Ala Leu Asp Arg Gly 
            340                 345                 350         
Leu Asp Glu Asn Lys Tyr Leu Val Pro Gly Leu Gly Asp Phe Gly Asp 
        355                 360                 365             
Arg Tyr Tyr Cys Val 
    370             

<210> 2
<211> 373
<212> PRT
<213> Artificial Sequence

<220> 
<223> derived from Saccharomyces cerevisiae

<400> 2
Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      
Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          
Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              
Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  
Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  
Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      
Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         
Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             
Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 
Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu Ala Ser 
145                 150                 155                 160 
Glu Pro Phe Lys Asn Val Tyr Leu Leu Pro Gln Thr Asn Gln Leu Leu 
                165                 170                 175     
Gly Leu Tyr Thr Ile Ile Ser Asn Lys Asn Thr Thr Arg Pro Asp Phe 
            180                 185                 190         
Ile Phe Tyr Ser Asp Arg Ile Ile Arg Leu Leu Val Glu Glu Gly Leu 
        195                 200                 205             
Asn His Leu Pro Val Gln Lys Gln Ile Val Glu Thr Asp Thr Asn Glu 
    210                 215                 220                 
Asn Phe Glu Gly Val Ser Phe Met Gly Lys Ile Cys Gly Val Ser Ile 
225                 230                 235                 240 
Val Arg Ala Gly Glu Ser Met Glu Gln Gly Leu Arg Asp Cys Cys Arg 
                245                 250                 255     
Ser Val Arg Ile Gly Lys Ile Leu Ile Gln Arg Asp Glu Glu Thr Ala 
            260                 265                 270         
Leu Pro Lys Leu Phe Tyr Glu Lys Leu Pro Glu Asp Ile Ser Glu Arg 
        275                 280                 285             
Tyr Val Phe Leu Leu Asp Pro Met Leu Ala Thr Gly Gly Ser Ala Ile 
    290                 295                 300                 
Met Ala Thr Glu Val Leu Ile Lys Arg Gly Val Lys Pro Glu Arg Ile 
305                 310                 315                 320 
Tyr Phe Leu Asn Leu Ile Cys Ser Lys Glu Gly Ile Glu Lys Tyr His 
                325                 330                 335     
Ala Ala Phe Pro Glu Val Arg Ile Val Thr Gly Ala Leu Asp Arg Gly 
            340                 345                 350         
Leu Asp Glu Asn Lys Tyr Leu Val Pro Gly Leu Gly Asp Phe Gly Asp 
        355                 360                 365             
Arg Tyr Tyr Cys Val 
    370             

<210> 3
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> derived from Escherichia Coli

<400> 3
Met Val Ser Asn Asn Ala Leu Glu Thr Ile Ile Asn Ala Arg Leu Pro 
1               5                   10                  15      
Gly Glu Glu Gly Leu Trp Gln Ile His Leu Gln Asp Gly Lys Ile Ser 
            20                  25                  30          
Ala Ile Asp Ala Gln Ser Gly Val Met Pro Ile Thr Glu Asn Ser Leu 
        35                  40                  45              
Asp Ala Glu Gln Gly Leu Val Ile Pro Pro Phe Val Glu Pro His Ile 
    50                  55                  60                  
His Leu Asp Thr Thr Gln Thr Ala Gly Gln Pro Asn Trp Asn Gln Ser 
65                  70                  75                  80  
Gly Thr Leu Phe Glu Gly Ile Glu Arg Trp Ala Glu Arg Lys Ala Leu 
                85                  90                  95      
Leu Thr His Asp Asp Val Lys Gln Arg Ala Trp Gln Thr Leu Lys Trp 
            100                 105                 110         
Gln Ile Ala Asn Gly Ile Gln His Val Arg Thr His Val Asp Val Ser 
        115                 120                 125             
Asp Ala Thr Leu Thr Ala Leu Lys Ala Met Leu Glu Val Lys Gln Glu 
    130                 135                 140                 
Val Ala Pro Trp Ile Asp Leu Gln Ile Val Ala Phe Pro Gln Glu Gly 
145                 150                 155                 160 
Ile Leu Ser Tyr Pro Asn Gly Glu Ala Leu Leu Glu Glu Ala Leu Arg 
                165                 170                 175     
Leu Gly Ala Asp Val Val Gly Ala Ile Pro His Phe Glu Phe Thr Arg 
            180                 185                 190         
Glu Tyr Gly Val Glu Ser Leu His Lys Thr Phe Ala Leu Ala Gln Lys 
        195                 200                 205             
Tyr Asp Arg Leu Ile Asp Val His Cys Asp Glu Ile Asp Asp Glu Gln 
    210                 215                 220                 
Ser Arg Phe Val Glu Thr Val Ala Ala Leu Ala His His Glu Gly Met 
225                 230                 235                 240 
Gly Ala Arg Val Thr Ala Ser His Thr Thr Ala Met His Ser Tyr Asn 
                245                 250                 255     
Gly Ala Tyr Thr Ser Arg Leu Phe Arg Leu Leu Lys Met Ser Gly Ile 
            260                 265                 270         
Asn Phe Val Ala Asn Pro Leu Val Asn Ile His Leu Gln Gly Arg Phe 
        275                 280                 285             
Asp Thr Tyr Pro Lys Arg Arg Gly Ile Thr Arg Val Lys Glu Met Leu 
    290                 295                 300                 
Glu Ser Gly Ile Asn Val Cys Phe Gly His Asp Asp Val Phe Asp Pro 
305                 310                 315                 320 
Trp Tyr Pro Leu Gly Thr Ala Asn Met Leu Gln Val Leu His Met Gly 
                325                 330                 335     
Leu His Val Cys Gln Leu Met Gly Tyr Gly Gln Ile Asn Asp Gly Leu 
            340                 345                 350         
Asn Leu Ile Thr His His Ser Ala Arg Thr Leu Asn Leu Gln Asp Tyr 
        355                 360                 365             
Gly Ile Ala Ala Gly Asn Ser Ala Asn Leu Ile Ile Leu Pro Ala Glu 
    370                 375                 380                 
Asn Gly Phe Asp Ala Leu Arg Arg Gln Val Pro Val Arg Tyr Ser Val 
385                 390                 395                 400 
Arg Gly Gly Lys Val Ile Ala Ser Thr Gln Pro Ala Gln Thr Thr Val 
                405                 410                 415     
Tyr Leu Glu Gln Pro Glu Ala Ile Asp Tyr Lys Arg Ile Ser Gly Ala 
            420                 425                 430         
Asn Gly Val Met Ala Lys Ile Val Glu Val Lys His Pro Leu Val Lys 
        435                 440                 445             
His Lys Leu Gly Leu Met Arg Glu Gln Asp Ile Ser Thr Lys Arg Phe 
    450                 455                 460                 
Arg Glu Leu Ala Ser Glu Val Gly Ser Leu Leu Thr Tyr Glu Ala Thr 
465                 470                 475                 480 
Ala Asp Leu Glu Thr Glu Lys Val Thr Ile Glu Gly Trp Asn Gly Pro 
                485                 490                 495     
Val Glu Ile Asp Gln Ile Lys Gly Lys Lys Ile Thr Val Val Pro Ile 
            500                 505                 510         
Leu Arg Ala Gly Leu Gly Met Met Asp Gly Val Leu Glu Asn Val Pro 
        515                 520                 525             
Ser Ala Arg Ile Ser Val Val Gly Met Tyr Arg Asn Glu Glu Thr Leu 
    530                 535                 540                 
Glu Pro Val Pro Tyr Phe Gln Lys Leu Val Ser Asn Ile Asp Glu Arg 
545                 550                 555                 560 
Met Ala Leu Ile Val Asp Pro Met Leu Ala Thr Gly Gly Ser Val Ile 
                565                 570                 575     
Ala Thr Ile Asp Leu Leu Lys Lys Ala Gly Cys Ser Ser Ile Lys Val 
            580                 585                 590         
Leu Val Leu Val Ala Ala Pro Glu Gly Ile Ala Ala Leu Glu Lys Ala 
        595                 600                 605             
His Pro Asp Val Glu Leu Tyr Thr Ala Ser Ile Asp Gln Gly Leu Asn 
    610                 615                 620                 
Glu His Gly Tyr Ile Ile Pro Gly Leu Gly Asp Ala Gly Asp Lys Ile 
625                 630                 635                 640 
Phe Gly Thr Lys 
                

<210> 4
<211> 158
<212> PRT
<213> Saccharomyces cerevisiae


<400> 4
Met Val Thr Gly Gly Met Ala Ser Lys Trp Asp Gln Lys Gly Met Asp 
1               5                   10                  15      
Ile Ala Tyr Glu Glu Ala Ala Leu Gly Tyr Lys Glu Gly Gly Val Pro 
            20                  25                  30          
Ile Gly Gly Cys Leu Ile Asn Asn Lys Asp Gly Ser Val Leu Gly Arg 
        35                  40                  45              
Gly His Asn Met Arg Phe Gln Lys Gly Ser Ala Thr Leu His Gly Glu 
    50                  55                  60                  
Ile Ser Thr Leu Glu Asn Cys Gly Arg Leu Glu Gly Lys Val Tyr Lys 
65                  70                  75                  80  
Asp Thr Thr Leu Tyr Thr Thr Leu Ser Pro Cys Asp Met Cys Thr Gly 
                85                  90                  95      
Ala Ile Ile Met Tyr Gly Ile Pro Arg Cys Val Val Gly Glu Asn Val 
            100                 105                 110         
Asn Phe Lys Ser Lys Gly Glu Lys Tyr Leu Gln Thr Arg Gly His Glu 
        115                 120                 125             
Val Val Val Val Asp Asp Glu Arg Cys Lys Lys Ile Met Lys Gln Phe 
    130                 135                 140                 
Ile Asp Glu Arg Pro Gln Asp Trp Phe Glu Asp Ile Gly Glu 
145                 150                 155             

<210> 5
<211> 150
<212> PRT
<213> Candida albicans


<400> 5
Met Ala Phe Asp Asp Lys Lys Gly Leu Gln Val Ala Leu Asp Gln Ala 
1               5                   10                  15      
Lys Lys Ser Tyr Ser Glu Gly Gly Ile Pro Ile Gly Ser Cys Ile Ile 
            20                  25                  30          
Ser Ser Asp Asp Thr Val Leu Gly Gln Gly His Asn Glu Arg Ile Gln 
        35                  40                  45              
Lys His Ser Ala Ile Leu His Gly Glu Met Ser Ala Leu Glu Asn Ala 
    50                  55                  60                  
Gly Arg Leu Pro Gly Lys Thr Tyr Lys Asp Cys Thr Ile Tyr Thr Thr 
65                  70                  75                  80  
Leu Ser Pro Cys Ser Met Cys Thr Gly Ala Ile Leu Leu Tyr Gly Phe 
                85                  90                  95      
Lys Arg Val Val Met Gly Glu Asn Val Asn Phe Leu Gly Asn Glu Lys 
            100                 105                 110         
Leu Leu Ile Glu Asn Gly Val Glu Val Val Asn Leu Asn Asp Gln Glu 
        115                 120                 125             
Cys Ile Asp Leu Met Ala Lys Phe Ile Lys Glu Lys Pro Gln Asp Trp 
    130                 135                 140                 
Asn Glu Asp Ile Gly Glu 
145                 150 

<210> 6
<211> 432
<212> PRT
<213> Escherichia coli


<400> 6
Met Trp Arg Leu Thr Val Ser Asn Asn Ala Leu Gln Thr Ile Ile Asn 
1               5                   10                  15      
Ala Gln Leu Pro Gly Lys Glu Gly Leu Trp Gln Ile His Leu His Asp 
            20                  25                  30          
Gly Lys Ile Ser Ala Ile Asp Ala Gln Ser Gly Val Met Pro Val Thr 
        35                  40                  45              
Glu Asn Ser Leu Asp Ala Glu Gln Gly Leu Val Leu Pro Pro Phe Val 
    50                  55                  60                  
Glu Pro His Ile His Leu Asp Thr Thr Gln Thr Ala Gly Gln Pro Asn 
65                  70                  75                  80  
Trp Asn Gln Ser Gly Thr Leu Phe Glu Gly Ile Glu Arg Trp Ala Glu 
                85                  90                  95      
Arg Lys Ala Leu Leu Thr His Asp Asp Val Lys Gln Arg Ala Trp Gln 
            100                 105                 110         
Thr Leu Lys Trp Gln Ile Ala Asn Gly Ile Gln His Val Arg Thr His 
        115                 120                 125             
Val Asp Val Ser Asp Ala Thr Leu Thr Ala Leu Lys Ala Met Leu Glu 
    130                 135                 140                 
Val Lys Gln Glu Val Ala Pro Trp Ile Asp Leu Gln Ile Val Ala Phe 
145                 150                 155                 160 
Pro Gln Glu Gly Ile Leu Ser Tyr Pro Asn Gly Glu Ala Leu Leu Glu 
                165                 170                 175     
Glu Ala Leu Arg Leu Gly Ala Asp Val Val Gly Ala Ile Pro His Phe 
            180                 185                 190         
Glu Phe Thr Arg Glu Tyr Gly Val Glu Ser Leu His Lys Thr Phe Ala 
        195                 200                 205             
Leu Ala Gln Lys Tyr Asp Arg Leu Ile Asp Val His Cys Asp Glu Ile 
    210                 215                 220                 
Asp Asp Glu Gln Ser Arg Phe Val Glu Thr Val Ala Ala Leu Ala His 
225                 230                 235                 240 
Arg Glu Gly Met Gly Ala Arg Val Thr Ala Ser His Thr Thr Ala Met 
                245                 250                 255     
His Ser Tyr Asn Gly Ala Tyr Thr Ser Arg Leu Phe Arg Leu Leu Lys 
            260                 265                 270         
Met Ser Gly Ile Asn Phe Val Ala Asn Pro Leu Val Asn Ile His Leu 
        275                 280                 285             
Gln Gly Arg Phe Asp Thr Tyr Pro Lys Arg Arg Gly Ile Thr Arg Val 
    290                 295                 300                 
Lys Glu Met Leu Glu Ser Gly Ile Asn Val Cys Phe Gly His Asp Asp 
305                 310                 315                 320 
Val Phe Asp Pro Trp Tyr Pro Leu Gly Thr Ala Asn Met Leu Gln Val 
                325                 330                 335     
Leu His Met Gly Leu His Val Cys Gln Leu Met Gly Tyr Gly Gln Ile 
            340                 345                 350         
Asn Asp Gly Leu Asn Leu Ile Thr His His Ser Ala Arg Thr Leu Asn 
        355                 360                 365             
Leu Gln Asp Tyr Gly Ile Ala Ala Gly Asn Ser Ala Asn Leu Ile Ile 
    370                 375                 380                 
Leu Pro Ala Glu Asn Gly Phe Asp Ala Leu Arg Arg Gln Val Pro Val 
385                 390                 395                 400 
Arg Tyr Ser Val Arg Gly Gly Lys Val Ile Ala Ser Thr Gln Pro Ala 
                405                 410                 415     
Gln Thr Thr Val Tyr Leu Glu Gln Pro Glu Ala Ile Asp Tyr Lys Arg 
            420                 425                 430         



<210> 7
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="oligonucleotide"
      /organism="Artificial Sequence"

<400> 7
tcccccgggt taaccactgc atgatgtaca                                     30


<210> 8
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="oligonucleotides"
      /organism="Artificial Sequence"

<400> 8
gccgagctcg aggtagccgt ttgtaattct                                     30


<210> 9
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..24
<223> /mol_type="unassigned DNA"
      /note="oligonucleotides"
      /organism="Artificial Sequence"

<400> 9
gcctggccat aactccaggc cgtt                                           24


<210> 10
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="oligonucleotides"
      /organism="Artificial Sequence"

<400> 10
gcccagctga tcgagccgta acgattttca                                     30


<210> 11
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="oligonucleotides"
      /organism="Artificial Sequence"

<400> 11
gccgcatgca tccttgaaca ccaataccga                                     30


<210> 12
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="oligonucleotide"
      /organism="Artificial Sequence"

<400> 12
gctctagaga ggtagccgtt tgtaatctg                                      29


<210> 13
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="oligonucleotide"
      /organism="Artificial Sequence"

<400> 13
cgcggatcct ttggtacagt ctagtatcca                                     30


<210> 14
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="oligonucleotide"
      /organism="Artificial Sequence"

<400> 14
tcccccgggt tataacagat gcagtatcca                                     30


<210> 15
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="oligonucleotide"
      /organism="Artificial Sequence"

<400> 15
gcccagctgt tcaatggcca tctgaaatcc                                     30


<210> 16
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..29
<223> /mol_type="unassigned DNA"
      /note="oligonucleotide"
      /organism="Artificial Sequence"

<400> 16
gaagatctag tatcgcatct aaaagatgg                                      29


<210> 17
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="oligonucleotide"
      /organism="Artificial Sequence"

<400> 17
gccgagctca cccacacgtt tttcgaaaaa                                     30


<210> 18
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..30
<223> /mol_type="unassigned DNA"
      /note="oligonucleotide"
      /organism="Artificial Sequence"

<400> 18
gccgcatgct tataacagat gcagtatcaa                                     30


