                         SEQUENCE LISTING

<110>  Sanofi
 
<120>  Exendin-4 Derivatives as peptidic dual GLP-1/Glucagon Receptor Agonists 

<130>  DE2014/029

<150>  EP14305501.0
<151>  2014-04-07

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  39
<212>  PRT
<213>  Heloderma suspectum


<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  1

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  2
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Amidated C-terminus

<400>  2

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  3
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  3

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  4
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Lys is functionalized at the amino side chain group as 
       Lys((S)-4-carboxy-4-hexadecanoylamino-butyryl)

<400>  4

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  5
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  5

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  6
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 

       Lys((S)-4-carboxy-4-octadecanoylamino-butyryl)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  6

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Ala Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  7
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 

       Lys((S)-4-carboxy-4-((S)-4-carboxy-4-hexadecanoylamino-butyrylami
       no)-butyryl)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  7

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Ala Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  8
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 

       Lys((S)-4-Carboxy-4-((S)-4-carboxy-4-hexadecanoylamino-butyrylami
       no)-butyryl)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  8

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  9
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 

       Lys((S)-4-Carboxy-4-octadecanoylamino-butyryl)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  9

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  10
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 

       Lys((S)-4-carboxy-4-hexadecanoylamino-butyryl)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  10

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  11
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 

       Lys((S)-4-carboxy-4-hexadecanoylamino-butyryl)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  11

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Ala Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  12
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 

       Lys((S)-4-Carboxy-4-((S)-4-carboxy-4-hexadecanoylamino-butyrylami
       no)-butyryl)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  12

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Ser Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  13
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 

       Lys((S)-4-Carboxy-4-((S)-4-carboxy-4-hexadecanoylamino-butyrylami
       no)-butyryl)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  13

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Ser Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  14
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 

       Lys((S)-4-Carboxy-4-((S)-4-carboxy-4-hexadecanoylamino-butyrylami
       no)-butyryl)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  14

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Lys Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  15
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 

       Lys((S)-4-carboxy-4-((S)-4-carboxy-4-hexadecanoylamino-butyrylami
       no)-butyryl)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  15

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  16
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 

       Lys((2-{2-[2-(2-{2-[(4S)-4-Carboxy-4-hexadecanoylamino-butyrylami
       no]-ethoxy}-ethoxy)-acetylamino]-ethoxy}-ethoxy)-acetyl)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  16

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  17
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 

       Lys((2-{2-[2-(2-{2-[(4S)-4-Carboxy-4-octadecanoylamino-butyrylami
       no]-ethoxy}-ethoxy)-acetylamino]-ethoxy}-ethoxy)-acetyl)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  17

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  18
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 

       Lys([2-(2-{2-[2-(2-{2-[2-(2-Octadecanoylamino-ethoxy)-ethoxy]-ace
       tylamino}-ethoxy)-ethoxy]-acetylamino}-ethoxy)-ethoxy]-acetyl)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  18

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  19
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 

       Lys((2-{2-[2-(2-{2-[(4S)-4-Carboxy-4-(17-carboxy-heptadecanoyl)am
       ino-butyrylamino]-ethoxy}-ethoxy)-acetylamino]-ethoxy}-ethoxy)-ac
       etyl)

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  19

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  20
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  20

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Ala Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  21
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 

       Lys((S)-4-Carboxy-4-((S)-4-carboxy-4-hexadecanoylamino-butyrylami
       no)-butyryl)

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  21

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  22
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  Lys is functionalized at the amino side chain group as 

       Lys((S)-4-Carboxy-4-((S)-4-carboxy-4-hexadecanoylamino-butyrylami
       no)-butyryl)

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  22

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Lys Ala Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  23
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  23

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Lys Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  24
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  24

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  25
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  Amidated C-terminus

<400>  25

His Xaa Gln Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Leu Asp Glu 
1               5                   10                  15      


Gln Arg Ala Lys Leu Phe Ile Glu Trp Leu Lys Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


