                         SEQUENCE LISTING

<110>  CSL Ltd
 
<120>  Half-life Extended Factor FVIIa Protein for Prevention and 
       Treatment of Bleeding and Dosing Regimens Therefor

<130>  516721

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  1022
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein: N-terminal human FVII followed by flexible linker
       followed by human serum albumin

<400>  1

Ala Asn Ala Phe Leu Glu Glu Leu Arg Pro Gly Ser Leu Glu Arg Glu 
1               5                   10                  15      


Cys Lys Glu Glu Gln Cys Ser Phe Glu Glu Ala Arg Glu Ile Phe Lys 
            20                  25                  30          


Asp Ala Glu Arg Thr Lys Leu Phe Trp Ile Ser Tyr Ser Asp Gly Asp 
        35                  40                  45              


Gln Cys Ala Ser Ser Pro Cys Gln Asn Gly Gly Ser Cys Lys Asp Gln 
    50                  55                  60                  


Leu Gln Ser Tyr Ile Cys Phe Cys Leu Pro Ala Phe Glu Gly Arg Asn 
65                  70                  75                  80  


Cys Glu Thr His Lys Asp Asp Gln Leu Ile Cys Val Asn Glu Asn Gly 
                85                  90                  95      


Gly Cys Glu Gln Tyr Cys Ser Asp His Thr Gly Thr Lys Arg Ser Cys 
            100                 105                 110         


Arg Cys His Glu Gly Tyr Ser Leu Leu Ala Asp Gly Val Ser Cys Thr 
        115                 120                 125             


Pro Thr Val Glu Tyr Pro Cys Gly Lys Ile Pro Ile Leu Glu Lys Arg 
    130                 135                 140                 


Asn Ala Ser Lys Pro Gln Gly Arg Ile Val Gly Gly Lys Val Cys Pro 
145                 150                 155                 160 


Lys Gly Glu Cys Pro Trp Gln Val Leu Leu Leu Val Asn Gly Ala Gln 
                165                 170                 175     


Leu Cys Gly Gly Thr Leu Ile Asn Thr Ile Trp Val Val Ser Ala Ala 
            180                 185                 190         


His Cys Phe Asp Lys Ile Lys Asn Trp Arg Asn Leu Ile Ala Val Leu 
        195                 200                 205             


Gly Glu His Asp Leu Ser Glu His Asp Gly Asp Glu Gln Ser Arg Arg 
    210                 215                 220                 


Val Ala Gln Val Ile Ile Pro Ser Thr Tyr Val Pro Gly Thr Thr Asn 
225                 230                 235                 240 


His Asp Ile Ala Leu Leu Arg Leu His Gln Pro Val Val Leu Thr Asp 
                245                 250                 255     


His Val Val Pro Leu Cys Leu Pro Glu Arg Thr Phe Ser Glu Arg Thr 
            260                 265                 270         


Leu Ala Phe Val Arg Phe Ser Leu Val Ser Gly Trp Gly Gln Leu Leu 
        275                 280                 285             


Asp Arg Gly Ala Thr Ala Leu Glu Leu Met Val Leu Asn Val Pro Arg 
    290                 295                 300                 


Leu Met Thr Gln Asp Cys Leu Gln Gln Ser Arg Lys Val Gly Asp Ser 
305                 310                 315                 320 


Pro Asn Ile Thr Glu Tyr Met Phe Cys Ala Gly Tyr Ser Asp Gly Ser 
                325                 330                 335     


Lys Asp Ser Cys Lys Gly Asp Ser Gly Gly Pro His Ala Thr His Tyr 
            340                 345                 350         


Arg Gly Thr Trp Tyr Leu Thr Gly Ile Val Ser Trp Gly Gln Gly Cys 
        355                 360                 365             


Ala Thr Val Gly His Phe Gly Val Tyr Thr Arg Val Ser Gln Tyr Ile 
    370                 375                 380                 


Glu Trp Leu Gln Lys Leu Met Arg Ser Glu Pro Arg Pro Gly Val Leu 
385                 390                 395                 400 


Leu Arg Ala Pro Phe Pro Ser Ser Gly Gly Ser Gly Gly Ser Gly Gly 
                405                 410                 415     


Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            420                 425                 430         


Gly Gly Ser Gly Ser Asp Ala His Lys Ser Glu Val Ala His Arg Phe 
        435                 440                 445             


Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe 
    450                 455                 460                 


Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu Val 
465                 470                 475                 480 


Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala 
                485                 490                 495     


Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys 
            500                 505                 510         


Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys 
        515                 520                 525             


Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp 
    530                 535                 540                 


Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met 
545                 550                 555                 560 


Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu 
                565                 570                 575     


Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu 
            580                 585                 590         


Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala 
        595                 600                 605             


Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp 
    610                 615                 620                 


Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu 
625                 630                 635                 640 


Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu 
                645                 650                 655     


Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val 
            660                 665                 670         


Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu 
        675                 680                 685             


Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn 
    690                 695                 700                 


Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu 
705                 710                 715                 720 


Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro 
                725                 730                 735     


Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val 
            740                 745                 750         


Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu 
        755                 760                 765             


Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu 
    770                 775                 780                 


Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala 
785                 790                 795                 800 


Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro 
                805                 810                 815     


Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe 
            820                 825                 830         


Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr 
        835                 840                 845             


Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser 
    850                 855                 860                 


Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala 
865                 870                 875                 880 


Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln 
                885                 890                 895     


Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys 
            900                 905                 910         


Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu 
        915                 920                 925             


Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe 
    930                 935                 940                 


Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile 
945                 950                 955                 960 


Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala 
                965                 970                 975     


Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val 
            980                 985                 990         


Glu Lys Cys Cys Lys Ala Asp Asp  Lys Glu Thr Cys Phe  Ala Glu Glu 
        995                 1000                 1005             


Gly Lys  Lys Leu Val Ala Ala  Ser Gln Ala Ala Leu  Gly Leu 
    1010                 1015                 1020         


<210>  2
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Ser Ser Ser Lys Ala Pro Pro Pro Ser Leu Pro Ser Pro Ser Arg 
1               5                   10                  15      


Leu Pro Gly Pro Ser Asp Thr Pro Ile Leu Pro Gln 
            20                  25              


