                         SEQUENCE LISTING

<110>  Park, Chulho
       Lee, Cynthia
 
<120>  METHODS, DEVICES, AND REAGENTS FOR MONITORING PACLITAXEL 
       CONCENTRATION IN PLASMA FOR PHARMACOKINETIC-GUIDED DOSING OF 
       PACLITAXEL

<130>  ATLC-1-53634

<150>  US 62/051757
<151>  2014-07-17

<150>  US 61/975386
<151>  2014-04-04

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
gacattgtga tgacccagtc tcaaaaattc atgtccataa cactaggaga gagggtcagc       60

atcacctgca agcccagtca gaatgtgggt tctgctgtaa cctggtggca acagaaacca      120

ggacaatctc ctaaactact gatttactca gcttccaatc ggtatactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagtaa tgtgcagtct      240

gaagacctgg cagattattt ctgtcaacaa tatagcagct atccgtacac gttcggaggg      300

gggaccaagc tggaaataaa acg                                              323


<210>  2
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Ile Thr Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Ile Thr Cys Lys Pro Ser Gln Asn Val Gly Ser Ala 
            20                  25                  30          


Val Thr Trp Trp Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  3
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  CDS
<222>  (1)..(333)

<400>  3
gag gtc cag ctg caa caa tct gga cct gaa ctg gtg aag cct ggg gct         48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag att tcc tgt aag gct tct gga tac acg ttc act gac tcc         96
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Ser           
            20                  25                  30                    

acc atg aac tgg gtg aag cag agc cat gga aag agc ctt gag tgg att        144
Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile           
        35                  40                  45                        

gga gag att gat cct aac aat ggt ggt act aac tac aat cag aag ttc        192
Gly Glu Ile Asp Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe           
    50                  55                  60                            

aag ggc aag gcc aca ttg act gta gac aag tcc tcc agc aca gcc tat        240
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr           
65                  70                  75                  80            

atg gag ctc cgc agc ctg aca tct gag gac tct gca gtc tat tac tgt        288
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aga ggg gtc tgg ggc caa ggc acc act ctc aca gtc tcc tca            333
Ala Arg Gly Val Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser               
            100                 105                 110                   


<210>  4
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Ser 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Val Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110     


<210>  5
<211>  337
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  CDS
<222>  (1)..(336)

<400>  5
gat gtt gtg atg acc caa act cca ctc tcc ctg cct gtc agt ctg gga         48
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly           
1               5                   10                  15                

gat caa gcc tcc atc tct tgc aga tct cgt cag agc ctt gta cac agt         96
Asp Gln Ala Ser Ile Ser Cys Arg Ser Arg Gln Ser Leu Val His Ser           
            20                  25                  30                    

aat gga aac acc tat tta cat tgg tac ctg cag aag cca ggc cag tct        144
Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser           
        35                  40                  45                        

cca aag ctc ctg atc tac aaa gtt tcc aac cga ttt tct ggg gtc cca        192
Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro           
    50                  55                  60                            

gac agg ttc agt ggt agt gga tca ggg aca gaa ttc aca ctc gag atc        240
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Glu Ile           
65                  70                  75                  80            

agc aga gtg gag gct gag gat ctg gga gtt tat ttc tgc tct caa agt        288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser           
                85                  90                  95                

aca cat gtt cct ccg acg ttc ggt gga ggc acc aag ctg gaa atc aaa c      337
Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys           
            100                 105                 110                   


<210>  6
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Arg Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Glu Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  7
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  CDS
<222>  (1)..(339)

<400>  7
gag gtg cag ctt cag gag tcg gga cct agt ctc gtg aaa cct tct cag         48
Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln           
1               5                   10                  15                

act ctg tcc ctc acc tgt tct gtc act ggc gac tcc atc acc agt ggt         96
Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly           
            20                  25                  30                    

tac tgg aac tgg atc cgg aaa ttc cca ggg aat aga ctt gag tac atg        144
Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Arg Leu Glu Tyr Met           
        35                  40                  45                        

ggg tac ata agc tac agt ggt agc act tac tac aat ccg tct ctc aaa        192
Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys           
    50                  55                  60                            

agt cga atc tcc atc act cga gac aca tcc aag aac cag tac tac cta        240
Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu           
65                  70                  75                  80            

cat ttg act tct gtg act act gag gac aca gcc aca tat tac tgt gcc        288
His Leu Thr Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala           
                85                  90                  95                

caa ggg gat ggc gcc tac tgg ggc caa ggc acc act ctc aca gtc tcc        336
Gln Gly Asp Gly Ala Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser           
            100                 105                 110                   

tca                                                                    339
Ser                                                                       
                                                                          


<210>  8
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Arg Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


His Leu Thr Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Gln Gly Asp Gly Ala Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
            100                 105                 110         


Ser 
    


