                         SEQUENCE LISTING

<110>  BiondVax Pharmaceuticals Ltd.
 
<120>  COMPOSITIONS OF MULTIMERIC-MULTIEPITOPE INFLUENZA POLYPEPTIDES 
       AND THEIR PRODUCTION

<130>  BNDVX/008/PCT

<160>  89    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  1

Glu Val Glu Thr 
1               


<210>  2
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  2

Met Ser Leu Leu Thr Glu Val Glu Thr His Thr Arg Asn Gly Trp 
1               5                   10                  15  


<210>  3
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  3

Pro Ile Arg Asn Glu Trp Gly Cys Arg 
1               5                   


<210>  4
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  4

Glu Thr Pro Ile Arg Asn Glu Trp Gly Cys 
1               5                   10  


<210>  5
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  5

Pro Ile Arg Asn Glu Trp Gly Cys Arg Cys Asn 
1               5                   10      


<210>  6
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  6

Leu Leu Thr Glu Val Glu Thr Pro Ile 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  7

Ser Leu Leu Thr Glu Val Glu Thr Pro 
1               5                   


<210>  8
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  8

Ser Leu Leu Thr Glu Val Glu Thr Pro Ile 
1               5                   10  


<210>  9
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  9

Leu Thr Glu Val Glu Thr Pro Leu Thr 
1               5                   


<210>  10
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  10

Met Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp 
1               5                   10                  15  


<210>  11
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  11

Met Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly 
1               5                   10                  15      


Cys Arg 
        


<210>  12
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  12

Met Ser Leu Leu Thr Glu Val Glu Thr Leu Thr Lys Asn Gly Trp 
1               5                   10                  15  


<210>  13
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  13

Met Ser Leu Leu Thr Glu Val Glu Thr Leu Thr Arg Asn Gly Trp 
1               5                   10                  15  


<210>  14
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  14

Leu Thr Glu Val Glu Thr Pro Ile Arg 
1               5                   


<210>  15
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  15

Leu Thr Glu Val Glu Thr Pro Ile Arg Asn 
1               5                   10  


<210>  16
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  16

Glu Val Glu Thr Pro Ile Arg Asn Glu 
1               5                   


<210>  17
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  17

Glu Val Glu Thr Pro Ile Arg Asn Glu Trp 
1               5                   10  


<210>  18
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  18

Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu 
1               5                   10      


<210>  19
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  19

Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly Cys Arg 
1               5                   10                  15  


<210>  20
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  20

Glu Val Glu Thr Pro Ile Arg Asn 
1               5               


<210>  21
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  21

Met Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Arg Asn Glu Trp Glu 
1               5                   10                  15      


Cys Arg 
        


<210>  22
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  22

Ser Leu Leu Thr Glu Val Glu Thr Pro Thr Arg Asn Glu Trp Glu Cys 
1               5                   10                  15      


Arg Cys Ser Asp Ser Ser Asp 
            20              


<210>  23
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  23

Ser Leu Leu Thr Glu Val Glu Thr Pro Ile Arg Asn Glu Trp Gly Cys 
1               5                   10                  15      


Arg Cys Asn Asp Ser Ser Asp 
            20              


<210>  24
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  24

Val Glu Thr Pro Ile Arg Asn Glu Trp 
1               5                   


<210>  25
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  25

Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu 
1               5                   10      


<210>  26
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  26

Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Pro 
1               5                   10      


<210>  27
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  27

Leu Leu Thr Glu Val Glu Thr Tyr Val 
1               5                   


<210>  28
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  28

Ser Ile Val Pro Ser Gly Pro Leu 
1               5               


<210>  29
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  29

Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu Asp Val 
1               5                   10                  15  


<210>  30
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  30

Gly Pro Leu Lys Ala Glu Ile Ala Gln Arg Leu Glu 
1               5                   10          


<210>  31
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  31

Arg Leu Glu Asp Val Phe Ala Gly Lys 
1               5                   


<210>  32
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  32

Ala Leu Met Glu Trp Leu Lys Thr Arg Pro Ile 
1               5                   10      


<210>  33
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  33

Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile 
1               5                   10  


<210>  34
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  34

Ile Leu Ser Pro Leu Thr Lys Gly Ile 
1               5                   


<210>  35
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  35

Leu Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val Pro Ser 
1               5                   10                  15      


Glu Arg Gly 
            


<210>  36
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  36

Thr Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
1               5                   10              


<210>  37
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  37

Lys Gly Ile Leu Gly Phe Val Phe Thr Leu Thr Val 
1               5                   10          


<210>  38
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  38

Gly Ile Leu Gly Phe Val Phe Thr Leu 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  39

Leu Gly Phe Val Phe Thr Leu Thr Val 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  40

Ile Leu Gly Phe Val Phe Thr Leu Thr 
1               5                   


<210>  41
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  41

Ala Ser Cys Met Gly Leu Ile Tyr 
1               5               


<210>  42
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  42

Arg Met Gly Ala Val Thr Thr Glu Val 
1               5                   


<210>  43
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  43

Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala 
1               5                   10      


<210>  44
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  44

Gln Met Val Ala Thr Thr Asn Pro Leu 
1               5                   


<210>  45
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  45

Gln Met Val Ala Thr Thr Asn Pro Leu Ile 
1               5                   10  


<210>  46
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  46

Arg Met Val Leu Ala Ser Thr Thr Ala Lys 
1               5                   10  


<210>  47
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  47

Asp Leu Leu Glu Asn Leu Gln Thr Tyr 
1               5                   


<210>  48
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  48

Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   10                  15      


Ser Leu 
        


<210>  49
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  49

Ser Lys Ala Phe Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   10                  15      


Ser Leu 
        


<210>  50
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  50

Ser Thr Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
1               5                   10                  15      


Ser Leu 
        


<210>  51
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  51

Trp Thr Gly Val Thr Gln Asn 
1               5           


<210>  52
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  52

Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro 
1               5                   10  


<210>  53
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  53

Trp Leu Thr Glu Lys Glu Gly Ser Tyr Pro 
1               5                   10  


<210>  54
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  54

Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met Arg 
1               5                   10                  15      


Asn Val Pro 
            


<210>  55
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  55

Gly Val Lys Leu Glu Ser Met Gly Ile Tyr Gln 
1               5                   10      


<210>  56
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  56

Glu Ile Ser Gly Val Lys Leu Glu Ser Met Gly 
1               5                   10      


<210>  57
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  57

Asn Val Lys Asn Leu Tyr Glu Lys Val Lys 
1               5                   10  


<210>  58
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  58

Lys Val Lys Ile Leu Pro Lys Asp Arg Trp Thr Gln His Thr Thr Thr 
1               5                   10                  15      


Gly Gly 
        


<210>  59
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  59

Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 
1               5                   10              


<210>  60
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  60

Lys Thr Gly Gly Pro Ile Tyr Arg Arg 
1               5                   


<210>  61
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  61

Cys Thr Glu Leu Lys Leu Ser Asp Tyr 
1               5                   


<210>  62
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  62

His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly Pro 
1               5                   10                  


<210>  63
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  63

His Pro Ser Ala Gly Lys Asp Pro Lys Lys Thr Gly Gly 
1               5                   10              


<210>  64
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  64

Phe Trp Arg Gly Glu Asn Gly Arg Lys Thr Arg Ser Ala Tyr Glu Arg 
1               5                   10                  15      


Met Cys Asn Ile Leu Lys Gly Lys 
            20                  


<210>  65
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  65

Ile Leu Arg Gly Ser Val Ala His Lys 
1               5                   


<210>  66
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  66

Lys Leu Leu Gln Asn Ser Gln Val Tyr 
1               5                   


<210>  67
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  67

Ser Ala Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Arg Gly 
1               5                   10                  15  


<210>  68
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  68

Ser Ala Ala Phe Glu Asp Leu Arg Val Ser Ser Phe Ile Arg Gly Thr 
1               5                   10                  15      


<210>  69
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  69

Ser Ala Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Arg Gly Tyr 
1               5                   10                  15      


<210>  70
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  70

Glu Leu Arg Ser Arg Tyr Trp Ala Ile Arg Thr Arg Ser Gly 
1               5                   10                  


<210>  71
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  71

Glu Leu Arg Ser Arg Tyr Trp Ala Ile 
1               5                   


<210>  72
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  72

Ser Arg Tyr Trp Ala Ile Arg Thr Arg 
1               5                   


<210>  73
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  73

Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly 
1               5                   10  


<210>  74
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  74

Ser Arg Tyr Trp Ala Ile Arg Thr Arg 
1               5                   


<210>  75
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  75

Leu Pro Phe Asp Lys Pro Thr Ile Met 
1               5                   


<210>  76
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  76

Val Ser Asp Gly Gly Pro Asn Leu Tyr 
1               5                   


<210>  77
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  77

Arg Arg Ser Phe Glu Leu Lys Lys Leu 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  78

Arg Arg Ala Thr Ala Ile Leu Arg Lys 
1               5                   


<210>  79
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  79

Arg Pro Ile Ile Arg Pro Ala Thr Leu 
1               5                   


<210>  80
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  80

Ala Asp Arg Gly Leu Leu Arg Asp Ile 
1               5                   


<210>  81
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  81

Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn 
1               5                   10              


<210>  82
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  82

Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly 
1               5                   10                  15      


Phe Leu Glu 
            


<210>  83
<211>  2199
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  83
atgcatatga gatctccagc taaacttctg aaagaacgtg gatttttcgg tgcaatcgct       60

ggttttctgg aggggtcgaa agcctacagt aactgttacc cctacgatgt gcccgattat      120

gccagcctgg gtagcctcct tacagaagtt gaaacttatg tgctcggctg gctgacaggg      180

aaaaacggcc tttatcctgt gtggaccggc gtgacgcaga acggattctg gcgtggcgaa      240

aatggacgta aaactcgcag tgcgtatgag cgcatgtgta acatcctcaa aggtaaaggc      300

ccgaaatatg tgaaacagaa tacattaaaa ttagccaccg gcgcgagcgc tgcctttgaa      360

gacctccgtg tgctcagttt tatccgcggt tatggggaac tgcgttctcg ctattgggcg      420

atccgtaccc ggtcaggggg tccaccggcg aagctgctga aagaacgtgg gttcttcggt      480

gcgattgccg gtttcttgga aggatcaaaa gcgtattcga actgctaccc gtatgatgtg      540

ccagattacg ccagcctggg ctccctcttg acagaggtcg aaacctatgt actgggttgg      600

ctgaccggta agaacggtct gtatccggtt tggactggtg tgacacaaaa cggcttttgg      660

cggggggaaa acggccggaa aacccgcagc gcttacgagc gcatgtgcaa cattctgaaa      720

ggcaaaggcc cgaaatacgt gaagcagaat acgctcaaac ttgccacggg cgcaagcgca      780

gcctttgaag acctgcgggt cttgagcttt atccgcggtt acggggagct gcggtcgcgc      840

tactgggcga ttcgtacgcg tagtggtgga cctcccgcga aacttctgaa agagcggggc      900

ttctttggag cgattgcggg cttcttggag ggaagcaaag cctactctaa ttgttaccca      960

tacgatgtgc ctgattatgc gagcctcggt agcttgctga cagaagtgga aacctacgtt     1020

ctcggctggc tgacgggcaa aaatggtctc tacccagtgt ggaccggagt tacccagaat     1080

gggttctggc gcggtgagaa cggccgtaaa acacgttcag cgtacgagcg gatgtgcaac     1140

atcttaaaag gcaaaggacc gaaatacgtc aagcagaata ctctgaagtt agccactggg     1200

gcctcagccg cctttgaaga ccttcgcgtc ttgagtttta tccggggtta tggggaactg     1260

cggagccgct actgggctat tcgtacgcgg tcgggtggcc cactcgagcc ggccaaattg     1320

ctcaaagaac gtggtttctt cggagcgatc gcaggttttc ttgaaggctc taaagcgtac     1380

agcaactgtt atccatacga tgtgccggat tacgccagtc tgggttccct cctgaccgag     1440

gtggaaacgt atgtactagg atggctcacg ggtaaaaatg gtctctatcc tgtgtggacg     1500

ggcgtaaccc agaacggctt ttggcggggc gaaaacggcc gcaaaacccg tagcgcatac     1560

gagcgtatgt gtaacatcct taaaggcaaa ggtccaaaat acgttaagca gaataccctg     1620

aaactggcta cgggcgccag tgcggccttc gaagatttac gggtgctgtc cttcatccgc     1680

ggctatggtg aactgcgctc tcgttactgg gcaatccgta cccgcagtgg cggacctccg     1740

gctaaactgt tgaaagaacg cggcttcttt ggtgctatcg caggttttct ggaaggaagt     1800

aaagcatatt cgaattgtta tccctacgac gtgccggatt atgcgtcgct cggttcgctg     1860

ctgaccgagg tggaaaccta cgttctaggc tggttgacag gtaagaacgg gctttacccg     1920

gtatggaccg gcgttaccca gaacggtttt tggcgcggtg aaaatggccg taaaactcgg     1980

tcagcatacg aacggatgtg caatatcttg aaaggtaaag gaccgaaata cgttaaacag     2040

aacacgctga aactggcaac aggcgccagc gcggcgtttg aggatttacg cgtcctgtca     2100

tttattcggg gctacggcga attacgtagt cgttattggg cgattcgtac ccgcagcgga     2160

gggctcgagt aataaaagct ttctagacat atgatgcat                            2199


<210>  84
<211>  723
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  84

Met His Met Arg Ser Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe 
1               5                   10                  15      


Gly Ala Ile Ala Gly Phe Leu Glu Gly Ser Lys Ala Tyr Ser Asn Cys 
            20                  25                  30          


Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Gly Ser Leu Leu Thr 
        35                  40                  45              


Glu Val Glu Thr Tyr Val Leu Gly Trp Leu Thr Gly Lys Asn Gly Leu 
    50                  55                  60                  


Tyr Pro Val Trp Thr Gly Val Thr Gln Asn Gly Phe Trp Arg Gly Glu 
65                  70                  75                  80  


Asn Gly Arg Lys Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn Ile Leu 
                85                  90                  95      


Lys Gly Lys Gly Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala 
            100                 105                 110         


Thr Gly Ala Ser Ala Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile 
        115                 120                 125             


Arg Gly Tyr Gly Glu Leu Arg Ser Arg Tyr Trp Ala Ile Arg Thr Arg 
    130                 135                 140                 


Ser Gly Gly Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly 
145                 150                 155                 160 


Ala Ile Ala Gly Phe Leu Glu Gly Ser Lys Ala Tyr Ser Asn Cys Tyr 
                165                 170                 175     


Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Gly Ser Leu Leu Thr Glu 
            180                 185                 190         


Val Glu Thr Tyr Val Leu Gly Trp Leu Thr Gly Lys Asn Gly Leu Tyr 
        195                 200                 205             


Pro Val Trp Thr Gly Val Thr Gln Asn Gly Phe Trp Arg Gly Glu Asn 
    210                 215                 220                 


Gly Arg Lys Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn Ile Leu Lys 
225                 230                 235                 240 


Gly Lys Gly Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 
                245                 250                 255     


Gly Ala Ser Ala Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Arg 
            260                 265                 270         


Gly Tyr Gly Glu Leu Arg Ser Arg Tyr Trp Ala Ile Arg Thr Arg Ser 
        275                 280                 285             


Gly Gly Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala 
    290                 295                 300                 


Ile Ala Gly Phe Leu Glu Gly Ser Lys Ala Tyr Ser Asn Cys Tyr Pro 
305                 310                 315                 320 


Tyr Asp Val Pro Asp Tyr Ala Ser Leu Gly Ser Leu Leu Thr Glu Val 
                325                 330                 335     


Glu Thr Tyr Val Leu Gly Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro 
            340                 345                 350         


Val Trp Thr Gly Val Thr Gln Asn Gly Phe Trp Arg Gly Glu Asn Gly 
        355                 360                 365             


Arg Lys Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn Ile Leu Lys Gly 
    370                 375                 380                 


Lys Gly Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly 
385                 390                 395                 400 


Ala Ser Ala Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Arg Gly 
                405                 410                 415     


Tyr Gly Glu Leu Arg Ser Arg Tyr Trp Ala Ile Arg Thr Arg Ser Gly 
            420                 425                 430         


Gly Pro Leu Glu Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly 
        435                 440                 445             


Ala Ile Ala Gly Phe Leu Glu Gly Ser Lys Ala Tyr Ser Asn Cys Tyr 
    450                 455                 460                 


Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Gly Ser Leu Leu Thr Glu 
465                 470                 475                 480 


Val Glu Thr Tyr Val Leu Gly Trp Leu Thr Gly Lys Asn Gly Leu Tyr 
                485                 490                 495     


Pro Val Trp Thr Gly Val Thr Gln Asn Gly Phe Trp Arg Gly Glu Asn 
            500                 505                 510         


Gly Arg Lys Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn Ile Leu Lys 
        515                 520                 525             


Gly Lys Gly Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 
    530                 535                 540                 


Gly Ala Ser Ala Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Arg 
545                 550                 555                 560 


Gly Tyr Gly Glu Leu Arg Ser Arg Tyr Trp Ala Ile Arg Thr Arg Ser 
                565                 570                 575     


Gly Gly Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala 
            580                 585                 590         


Ile Ala Gly Phe Leu Glu Gly Ser Lys Ala Tyr Ser Asn Cys Tyr Pro 
        595                 600                 605             


Tyr Asp Val Pro Asp Tyr Ala Ser Leu Gly Ser Leu Leu Thr Glu Val 
    610                 615                 620                 


Glu Thr Tyr Val Leu Gly Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro 
625                 630                 635                 640 


Val Trp Thr Gly Val Thr Gln Asn Gly Phe Trp Arg Gly Glu Asn Gly 
                645                 650                 655     


Arg Lys Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn Ile Leu Lys Gly 
            660                 665                 670         


Lys Gly Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly 
        675                 680                 685             


Ala Ser Ala Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Arg Gly 
    690                 695                 700                 


Tyr Gly Glu Leu Arg Ser Arg Tyr Trp Ala Ile Arg Thr Arg Ser Gly 
705                 710                 715                 720 


Gly Leu Glu 
            


<210>  85
<211>  1299
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  85
atgcatatga gatctccagc taaacttctg aaagaacgtg gatttttcgg tgcaatcgct       60

ggttttctgg agccaccggc gaagctgctg aaagaacgtg ggttcttcgg tgcgattgcc      120

ggtttcttgg aacctcccgc gaaacttctg aaagagcggg gcttctttgg agcgattgcg      180

ggcttcttgg agccatcgaa agcctacagt aactgttacc cctacgatgt gcccgattat      240

gccagcctgc cttcaaaagc gtattcgaac tgctacccgt atgatgtgcc agattacgcc      300

agcctgccaa gcaaagccta ctctaattgt tacccatacg atgtgcctga ttatgcgagc      360

ctccctagcc tccttacaga agttgaaact tatgtgctca gcttgctgac agaagtggaa      420

acctacgttc tcagcttgct gacagaagtg gaaacctacg ttctctggct gacagggaaa      480

aacggccttt atccttggct gaccggtaag aacggtctgt atccgtggct gacgggcaaa      540

aatggtctct acccatggac cggcgtgacg cagaaccctt ggactggtgt gacacaaaac      600

ccatggaccg gagttaccca gaatcctttc tggcgtggcg aaaatggacg taaaactcgc      660

agtgcgtatg agcgcatgtg taacatcctc aaaggtaaac ccttttggcg gggggaaaac      720

ggccggaaaa cccgcagcgc ttacgagcgc atgtgcaaca ttctgaaagg caaaccattc      780

tggcgcggtg agaacggccg taaaacacgt tcagcgtacg agcggatgtg caacatctta      840

aaaggcaaac ctccgaaata cgtgaagcag aatacgctca aacttgccac gccaccgaaa      900

tacgtcaagc agaatactct gaagttagcc actccgccga aatacgtcaa gcagaatact      960

ctgaagttag ccactccttc agccgccttt gaagaccttc gcgtcttgag ttttatccgg     1020

ggttatccaa gcgcagcctt tgaagacctg cgggtcttga gctttatccg cggttaccct     1080

tcagccgcct ttgaagacct tcgcgtcttg agttttatcc ggggttatcc agaactgcgt     1140

tctcgctatt gggcgatccg tacccggtca gggccggagc tgcggtcgcg ctactgggcg     1200

attcgtacgc gtagtggtcc agaactgcgg agccgctact gggctattcg tacgcggtcg     1260

ggttaataac tcgagaggct ttctagacat atgatgcat                            1299


<210>  86
<211>  421
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  86

Met His Met Arg Ser Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe 
1               5                   10                  15      


Gly Ala Ile Ala Gly Phe Leu Glu Pro Pro Ala Lys Leu Leu Lys Glu 
            20                  25                  30          


Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu Pro Pro Ala Lys 
        35                  40                  45              


Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala Gly Phe Leu Glu 
    50                  55                  60                  


Pro Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr 
65                  70                  75                  80  


Ala Ser Leu Pro Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val 
                85                  90                  95      


Pro Asp Tyr Ala Ser Leu Pro Ser Lys Ala Tyr Ser Asn Cys Tyr Pro 
            100                 105                 110         


Tyr Asp Val Pro Asp Tyr Ala Ser Leu Pro Ser Leu Leu Thr Glu Val 
        115                 120                 125             


Glu Thr Tyr Val Leu Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu 
    130                 135                 140                 


Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Trp Leu Thr Gly Lys 
145                 150                 155                 160 


Asn Gly Leu Tyr Pro Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Trp 
                165                 170                 175     


Leu Thr Gly Lys Asn Gly Leu Tyr Pro Trp Thr Gly Val Thr Gln Asn 
            180                 185                 190         


Pro Trp Thr Gly Val Thr Gln Asn Pro Trp Thr Gly Val Thr Gln Asn 
        195                 200                 205             


Pro Phe Trp Arg Gly Glu Asn Gly Arg Lys Thr Arg Ser Ala Tyr Glu 
    210                 215                 220                 


Arg Met Cys Asn Ile Leu Lys Gly Lys Pro Phe Trp Arg Gly Glu Asn 
225                 230                 235                 240 


Gly Arg Lys Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn Ile Leu Lys 
                245                 250                 255     


Gly Lys Pro Phe Trp Arg Gly Glu Asn Gly Arg Lys Thr Arg Ser Ala 
            260                 265                 270         


Tyr Glu Arg Met Cys Asn Ile Leu Lys Gly Lys Pro Pro Lys Tyr Val 
        275                 280                 285             


Lys Gln Asn Thr Leu Lys Leu Ala Thr Pro Pro Lys Tyr Val Lys Gln 
    290                 295                 300                 


Asn Thr Leu Lys Leu Ala Thr Pro Pro Lys Tyr Val Lys Gln Asn Thr 
305                 310                 315                 320 


Leu Lys Leu Ala Thr Pro Ser Ala Ala Phe Glu Asp Leu Arg Val Leu 
                325                 330                 335     


Ser Phe Ile Arg Gly Tyr Pro Ser Ala Ala Phe Glu Asp Leu Arg Val 
            340                 345                 350         


Leu Ser Phe Ile Arg Gly Tyr Pro Ser Ala Ala Phe Glu Asp Leu Arg 
        355                 360                 365             


Val Leu Ser Phe Ile Arg Gly Tyr Pro Glu Leu Arg Ser Arg Tyr Trp 
    370                 375                 380                 


Ala Ile Arg Thr Arg Ser Gly Pro Glu Leu Arg Ser Arg Tyr Trp Ala 
385                 390                 395                 400 


Ile Arg Thr Arg Ser Gly Pro Glu Leu Arg Ser Arg Tyr Trp Ala Ile 
                405                 410                 415     


Arg Thr Arg Ser Gly 
            420     


<210>  87
<211>  1335
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic polynucleotide

<400>  87
atgagatctc cggcgaaact gctgaaagaa cgtggctttt ttggcgcgat tgcgggcttt       60

ctggaaggca gcaaagcgta tagcaactgc tatccgtatg atgtgccgga ttacgcgagt      120

ctgggctctc tgctgaccga agtggaaacc tatgtgctgg gctggctgac cggcaaaaac      180

ggcctgtatc cggtgtggac cggcgtgacc cagaacggct tttggcgtgg cgaaaacggc      240

cgtaaaaccc gtagcgcgta tgaacgtatg tgcaacatcc tgaaaggcaa aggcccgaaa      300

tatgtgaaac agaacaccct gaaactggcc accggtgcga gcgcggcgtt tgaggacctg      360

cgtgttctga gctttattcg tggctatggc gaactgcgta gccgttattg ggcgattcgt      420

acccgtagcg gtggtccgcc ggccaaactg ctgaaagaac gcggtttctt cggtgcgatc      480

gccggttttc tggaaggtag caaagcctac tctaattgtt acccgtacga tgttccggat      540

tacgccagcc tgggtagcct gctgaccgaa gttgaaacct acgttctggg ttggctgacc      600

ggtaaaaatg gtctgtaccc ggtttggacc ggtgttaccc agaatggttt ctggcgcggt      660

gaaaatggtc gcaaaacccg cagcgcctac gaacgcatgt gtaatattct gaaaggtaaa      720

ggtccgaaat acgttaaaca gaataccctg aaactggcca ccggcgccag cgccgccttc      780

gaggacctgc gcgttctgag cttcatccgc ggttacggtg aactgcgcag ccgctactgg      840

gccatccgca cccgcagcgg tggtccgccg gcgaaactgc tgaaagaacg cggttttttt      900

ggtgccattg cgggttttct ggaaggtagc aaagcctatt ctaactgcta tccgtacgat      960

gttccggatt atgcgagcct gggtagcctg ctgaccgaag tggaaaccta tgttctgggt     1020

tggctgaccg gcaaaaacgg tctgtatccg gtttggaccg gtgtgaccca gaacggtttt     1080

tggcgcggtg aaaacggccg taaaacccgc agcgcctatg aacgcatgtg caacattctg     1140

aaaggcaaag gtccgaaata cgtgaaacag aacaccctga aactggccac cggcgcgagc     1200

gcggcctttg aggacctgcg cgttctgagc tttattcgcg gctatggtga actgcgcagc     1260

cgctattggg cgattcgtac ccgcagcggc ggctaataac tcgagaagct ttctagacat     1320

atgatgcatg agctc                                                      1335


<210>  88
<211>  431
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic polypeptide

<400>  88

Met Arg Ser Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala 
1               5                   10                  15      


Ile Ala Gly Phe Leu Glu Gly Ser Lys Ala Tyr Ser Asn Cys Tyr Pro 
            20                  25                  30          


Tyr Asp Val Pro Asp Tyr Ala Ser Leu Gly Ser Leu Leu Thr Glu Val 
        35                  40                  45              


Glu Thr Tyr Val Leu Gly Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro 
    50                  55                  60                  


Val Trp Thr Gly Val Thr Gln Asn Gly Phe Trp Arg Gly Glu Asn Gly 
65                  70                  75                  80  


Arg Lys Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn Ile Leu Lys Gly 
                85                  90                  95      


Lys Gly Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly 
            100                 105                 110         


Ala Ser Ala Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Arg Gly 
        115                 120                 125             


Tyr Gly Glu Leu Arg Ser Arg Tyr Trp Ala Ile Arg Thr Arg Ser Gly 
    130                 135                 140                 


Gly Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile 
145                 150                 155                 160 


Ala Gly Phe Leu Glu Gly Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr 
                165                 170                 175     


Asp Val Pro Asp Tyr Ala Ser Leu Gly Ser Leu Leu Thr Glu Val Glu 
            180                 185                 190         


Thr Tyr Val Leu Gly Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Val 
        195                 200                 205             


Trp Thr Gly Val Thr Gln Asn Gly Phe Trp Arg Gly Glu Asn Gly Arg 
    210                 215                 220                 


Lys Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn Ile Leu Lys Gly Lys 
225                 230                 235                 240 


Gly Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Ala 
                245                 250                 255     


Ser Ala Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Arg Gly Tyr 
            260                 265                 270         


Gly Glu Leu Arg Ser Arg Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly 
        275                 280                 285             


Pro Pro Ala Lys Leu Leu Lys Glu Arg Gly Phe Phe Gly Ala Ile Ala 
    290                 295                 300                 


Gly Phe Leu Glu Gly Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp 
305                 310                 315                 320 


Val Pro Asp Tyr Ala Ser Leu Gly Ser Leu Leu Thr Glu Val Glu Thr 
                325                 330                 335     


Tyr Val Leu Gly Trp Leu Thr Gly Lys Asn Gly Leu Tyr Pro Val Trp 
            340                 345                 350         


Thr Gly Val Thr Gln Asn Gly Phe Trp Arg Gly Glu Asn Gly Arg Lys 
        355                 360                 365             


Thr Arg Ser Ala Tyr Glu Arg Met Cys Asn Ile Leu Lys Gly Lys Gly 
    370                 375                 380                 


Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Ala Ser 
385                 390                 395                 400 


Ala Ala Phe Glu Asp Leu Arg Val Leu Ser Phe Ile Arg Gly Tyr Gly 
                405                 410                 415     


Glu Leu Arg Ser Arg Tyr Trp Ala Ile Arg Thr Arg Ser Gly Gly 
            420                 425                 430     


<210>  89
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  89

Pro Arg Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 
1               5                   10              


