                         SEQUENCE LISTING

<110>  Swedish Orphan Biovitrum
 
<120>  Modified sulfamidase and production thereof

<130>  21068924

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  482
<212>  PRT
<213>  Homo sapiens

<400>  1

Arg Pro Arg Asn Ala Leu Leu Leu Leu Ala Asp Asp Gly Gly Phe Glu 
1               5                   10                  15      


Ser Gly Ala Tyr Asn Asn Ser Ala Ile Ala Thr Pro His Leu Asp Ala 
            20                  25                  30          


Leu Ala Arg Arg Ser Leu Leu Phe Arg Asn Ala Phe Thr Ser Val Ser 
        35                  40                  45              


Ser Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly Leu Pro Gln His 
    50                  55                  60                  


Gln Asn Gly Met Tyr Gly Leu His Gln Asp Val His His Phe Asn Ser 
65                  70                  75                  80  


Phe Asp Lys Val Arg Ser Leu Pro Leu Leu Leu Ser Gln Ala Gly Val 
                85                  90                  95      


Arg Thr Gly Ile Ile Gly Lys Lys His Val Gly Pro Glu Thr Val Tyr 
            100                 105                 110         


Pro Phe Asp Phe Ala Tyr Thr Glu Glu Asn Gly Ser Val Leu Gln Val 
        115                 120                 125             


Gly Arg Asn Ile Thr Arg Ile Lys Leu Leu Val Arg Lys Phe Leu Gln 
    130                 135                 140                 


Thr Gln Asp Asp Arg Pro Phe Phe Leu Tyr Val Ala Phe His Asp Pro 
145                 150                 155                 160 


His Arg Cys Gly His Ser Gln Pro Gln Tyr Gly Thr Phe Cys Glu Lys 
                165                 170                 175     


Phe Gly Asn Gly Glu Ser Gly Met Gly Arg Ile Pro Asp Trp Thr Pro 
            180                 185                 190         


Gln Ala Tyr Asp Pro Leu Asp Val Leu Val Pro Tyr Phe Val Pro Asn 
        195                 200                 205             


Thr Pro Ala Ala Arg Ala Asp Leu Ala Ala Gln Tyr Thr Thr Val Gly 
    210                 215                 220                 


Arg Met Asp Gln Gly Val Gly Leu Val Leu Gln Glu Leu Arg Asp Ala 
225                 230                 235                 240 


Gly Val Leu Asn Asp Thr Leu Val Ile Phe Thr Ser Asp Asn Gly Ile 
                245                 250                 255     


Pro Phe Pro Ser Gly Arg Thr Asn Leu Tyr Trp Pro Gly Thr Ala Glu 
            260                 265                 270         


Pro Leu Leu Val Ser Ser Pro Glu His Pro Lys Arg Trp Gly Gln Val 
        275                 280                 285             


Ser Glu Ala Tyr Val Ser Leu Leu Asp Leu Thr Pro Thr Ile Leu Asp 
    290                 295                 300                 


Trp Phe Ser Ile Pro Tyr Pro Ser Tyr Ala Ile Phe Gly Ser Lys Thr 
305                 310                 315                 320 


Ile His Leu Thr Gly Arg Ser Leu Leu Pro Ala Leu Glu Ala Glu Pro 
                325                 330                 335     


Leu Trp Ala Thr Val Phe Gly Ser Gln Ser His His Glu Val Thr Met 
            340                 345                 350         


Ser Tyr Pro Met Arg Ser Val Gln His Arg His Phe Arg Leu Val His 
        355                 360                 365             


Asn Leu Asn Phe Lys Met Pro Phe Pro Ile Asp Gln Asp Phe Tyr Val 
    370                 375                 380                 


Ser Pro Thr Phe Gln Asp Leu Leu Asn Arg Thr Thr Ala Gly Gln Pro 
385                 390                 395                 400 


Thr Gly Trp Tyr Lys Asp Leu Arg His Tyr Tyr Tyr Arg Ala Arg Trp 
                405                 410                 415     


Glu Leu Tyr Asp Arg Ser Arg Asp Pro His Glu Thr Gln Asn Leu Ala 
            420                 425                 430         


Thr Asp Pro Arg Phe Ala Gln Leu Leu Glu Met Leu Arg Asp Gln Leu 
        435                 440                 445             


Ala Lys Trp Gln Trp Glu Thr His Asp Pro Trp Val Cys Ala Pro Asp 
    450                 455                 460                 


Gly Val Leu Glu Glu Lys Leu Ser Pro Gln Cys Gln Pro Leu His Asn 
465                 470                 475                 480 


Glu Leu 
        


<210>  2
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Ser Arg Pro Arg Asn Ala Leu Leu Leu Leu Ala Asp Asp Gly Gly 
1               5                   10                  15      


Phe Glu Ser Gly Ala Tyr Asn Asn Ser Ala Ile Ala Thr Pro His Leu 
            20                  25                  30          


Asp Ala Leu Ala Arg Arg Ser Leu Leu Phe Arg Asn Ala Phe Thr Ser 
        35                  40                  45              


Val Ser Ser Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly Leu Pro 
    50                  55                  60                  


Gln His Gln Asn Gly Met Tyr Gly Leu His Gln Asp Val His His Phe 
65                  70                  75                  80  


Asn Ser Phe Asp Lys Val Arg Ser Leu Pro Leu Leu Leu Ser Gln Ala 
                85                  90                  95      


Gly Val Arg Thr Gly Ile Ile Gly Lys Lys His Val Gly Pro Glu Thr 
            100                 105                 110         


Val Tyr Pro Phe Asp Phe Ala Tyr Thr Glu Glu Asn Gly Ser Val Leu 
        115                 120                 125             


Gln Val Gly Arg Asn Ile Thr Arg Ile Lys Leu Leu Val Arg Lys Phe 
    130                 135                 140                 


Leu Gln Thr Gln Asp Asp Arg Pro Phe Phe Leu Tyr Val Ala Phe His 
145                 150                 155                 160 


Asp Pro His Arg Cys Gly His Ser Gln Pro Gln Tyr Gly Thr Phe Cys 
                165                 170                 175     


Glu Lys Phe Gly Asn Gly Glu Ser Gly Met Gly Arg Ile Pro Asp Trp 
            180                 185                 190         


Thr Pro Gln Ala Tyr Asp Pro Leu Asp Val Leu Val Pro Tyr Phe Val 
        195                 200                 205             


Pro Asn Thr Pro Ala Ala Arg Ala Asp Leu Ala Ala Gln Tyr Thr Thr 
    210                 215                 220                 


Val Gly Arg Met Asp Gln Gly Val Gly Leu Val Leu Gln Glu Leu Arg 
225                 230                 235                 240 


Asp Ala Gly Val Leu Asn Asp Thr Leu Val Ile Phe Thr Ser Asp Asn 
                245                 250                 255     


Gly Ile Pro Phe Pro Ser Gly Arg Thr Asn Leu Tyr Trp Pro Gly Thr 
            260                 265                 270         


Ala Glu Pro Leu Leu Val Ser Ser Pro Glu His Pro Lys Arg Trp Gly 
        275                 280                 285             


Gln Val Ser Glu Ala Tyr Val Ser Leu Leu Asp Leu Thr Pro Thr Ile 
    290                 295                 300                 


Leu Asp Trp Phe Ser Ile Pro Tyr Pro Ser Tyr Ala Ile Phe Gly Ser 
305                 310                 315                 320 


Lys Thr Ile His Leu Thr Gly Arg Ser Leu Leu Pro Ala Leu Glu Ala 
                325                 330                 335     


Glu Pro Leu Trp Ala Thr Val Phe Gly Ser Gln Ser His His Glu Val 
            340                 345                 350         


Thr Met Ser Tyr Pro Met Arg Ser Val Gln His Arg His Phe Arg Leu 
        355                 360                 365             


Val His Asn Leu Asn Phe Lys Met Pro Phe Pro Ile Asp Gln Asp Phe 
    370                 375                 380                 


Tyr Val Ser Pro Thr Phe Gln Asp Leu Leu Asn Arg Thr Thr Ala Gly 
385                 390                 395                 400 


Gln Pro Thr Gly Trp Tyr Lys Asp Leu Arg His Tyr Tyr Tyr Arg Ala 
                405                 410                 415     


Arg Trp Glu Leu Tyr Asp Arg Ser Arg Asp Pro His Glu Thr Gln Asn 
            420                 425                 430         


Leu Ala Thr Asp Pro Arg Phe Ala Gln Leu Leu Glu Met Leu Arg Asp 
        435                 440                 445             


Gln Leu Ala Lys Trp Gln Trp Glu Thr His Asp Pro Trp Val Cys Ala 
    450                 455                 460                 


Pro Asp Gly Val Leu Glu Glu Lys Leu Ser Pro Gln Cys Gln Pro Leu 
465                 470                 475                 480 


His Asn Glu Leu 
                


<210>  3
<211>  484
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg Pro Arg Asn Ala Leu Leu Leu Leu Ala Asp Asp Gly Gly Phe Glu 
1               5                   10                  15      


Ser Gly Ala Tyr Asn Asn Ser Ala Ile Ala Thr Pro His Leu Asp Ala 
            20                  25                  30          


Leu Ala Arg Arg Ser Leu Leu Phe Arg Asn Ala Phe Thr Ser Val Ser 
        35                  40                  45              


Ser Cys Ser Pro Ser Arg Ala Ser Leu Leu Thr Gly Leu Pro Gln His 
    50                  55                  60                  


Gln Asn Gly Met Tyr Gly Leu His Gln Asp Val His His Phe Asn Ser 
65                  70                  75                  80  


Phe Asp Lys Val Arg Ser Leu Pro Leu Leu Leu Ser Gln Ala Gly Val 
                85                  90                  95      


Arg Thr Gly Ile Ile Gly Lys Lys His Val Gly Pro Glu Thr Val Tyr 
            100                 105                 110         


Pro Phe Asp Phe Ala Tyr Thr Glu Glu Asn Gly Ser Val Leu Gln Val 
        115                 120                 125             


Gly Arg Asn Ile Thr Arg Ile Lys Leu Leu Val Arg Lys Phe Leu Gln 
    130                 135                 140                 


Thr Gln Asp Asp Arg Pro Phe Phe Leu Tyr Val Ala Phe His Asp Pro 
145                 150                 155                 160 


His Arg Cys Gly His Ser Gln Pro Gln Tyr Gly Thr Phe Cys Glu Lys 
                165                 170                 175     


Phe Gly Asn Gly Glu Ser Gly Met Gly Arg Ile Pro Asp Trp Thr Pro 
            180                 185                 190         


Gln Ala Tyr Asp Pro Leu Asp Val Leu Val Pro Tyr Phe Val Pro Asn 
        195                 200                 205             


Thr Pro Ala Ala Arg Ala Asp Leu Ala Ala Gln Tyr Thr Thr Val Gly 
    210                 215                 220                 


Arg Met Asp Gln Gly Val Gly Leu Val Leu Gln Glu Leu Arg Asp Ala 
225                 230                 235                 240 


Gly Val Leu Asn Asp Thr Leu Val Ile Phe Thr Ser Asp Asn Gly Ile 
                245                 250                 255     


Pro Phe Pro Ser Gly Arg Thr Asn Leu Tyr Trp Pro Gly Thr Ala Glu 
            260                 265                 270         


Pro Leu Leu Val Ser Ser Pro Glu His Pro Lys Arg Trp Gly Gln Val 
        275                 280                 285             


Ser Glu Ala Tyr Val Ser Leu Leu Asp Leu Thr Pro Thr Ile Leu Asp 
    290                 295                 300                 


Trp Phe Ser Ile Pro Tyr Pro Ser Tyr Ala Ile Phe Gly Ser Lys Thr 
305                 310                 315                 320 


Ile His Leu Thr Gly Arg Ser Leu Leu Pro Ala Leu Glu Ala Glu Pro 
                325                 330                 335     


Leu Trp Ala Thr Val Phe Gly Ser Gln Ser His His Glu Val Thr Met 
            340                 345                 350         


Ser Tyr Pro Met Arg Ser Val Gln His Arg His Phe Arg Leu Val His 
        355                 360                 365             


Asn Leu Asn Phe Lys Met Pro Phe Pro Ile Asp Gln Asp Phe Tyr Val 
    370                 375                 380                 


Ser Pro Thr Phe Gln Asp Leu Leu Asn Arg Thr Thr Ala Gly Gln Pro 
385                 390                 395                 400 


Thr Gly Trp Tyr Lys Asp Leu Arg His Tyr Tyr Tyr Arg Ala Arg Trp 
                405                 410                 415     


Glu Leu Tyr Asp Arg Ser Arg Asp Pro His Glu Thr Gln Asn Leu Ala 
            420                 425                 430         


Thr Asp Pro Arg Phe Ala Gln Leu Leu Glu Met Leu Arg Asp Gln Leu 
        435                 440                 445             


Ala Lys Trp Gln Trp Glu Thr His Asp Pro Trp Val Cys Ala Pro Asp 
    450                 455                 460                 


Gly Val Leu Glu Glu Lys Leu Ser Pro Gln Cys Gln Pro Leu His Asn 
465                 470                 475                 480 


Glu Leu Gly Ser 
                


