                         SEQUENCE LISTING

<110>  Boehringer Ingelheim Vetmedica GmbH
 
<120>  Improved Modular Antigen Transportation Molecules and Uses therof

<130>  P01-3045 PCT+FF

<150>  EP14162575.6
<151>  2014-03-31

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  synthetic peptide

<400>  1

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  2
<211>  208
<212>  PRT
<213>  equus caballus

<400>  2

Met Glu Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Val Pro Ile 
1               5                   10                  15      


Leu Gly Gln Arg Pro Ala Ala Pro Glu Arg Lys Cys Ser Arg Gly Ala 
            20                  25                  30          


Leu Tyr Thr Gly Phe Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln 
        35                  40                  45              


Ala Thr Thr Ala Tyr Phe Leu Phe Gln Gln Gln Gly Arg Leu Asp Lys 
    50                  55                  60                  


Leu Thr Val Thr Ala Gln Asn Leu Gln Leu Glu Lys Leu Arg Met Lys 
65                  70                  75                  80  


Leu Pro Lys Ser Ala Lys Pro Val Ser Lys Ile Arg Val Ala Thr Pro 
                85                  90                  95      


Met Leu Met Gln Ala Leu Pro Met Glu Gly Leu Ser His Gly Pro Met 
            100                 105                 110         


Gln Asn Ala Thr Lys Tyr Gly Asn Thr Thr Gln Asp His Val Met His 
        115                 120                 125             


Leu Leu Leu Arg Ala Asp Pro Leu Lys Val Tyr Pro Gln Leu Lys Gly 
    130                 135                 140                 


Ser Phe Gln Glu Asn Leu Lys His Leu Lys Ser Thr Met Asp Gly Leu 
145                 150                 155                 160 


Asp Trp Lys Val Phe Glu Asn Trp Met His Gln Trp Leu Leu Phe Glu 
                165                 170                 175     


Met Ser Arg Asn Ser Leu Glu Glu Lys Pro Thr Gln Gly Pro Thr Lys 
            180                 185                 190         


Glu Pro Leu Glu Ile Glu Asp Leu Ser Ser Gly Val Gly Met Ala Lys 
        195                 200                 205             


<210>  3
<211>  152
<212>  PRT
<213>  Culicoides spec.

<400>  3

Met Lys Phe Pro Thr Phe Leu Ile Leu Ala Phe Phe Leu Ser Leu Tyr 
1               5                   10                  15      


Ile Ser Ser Thr Ala Ser Arg Arg Lys His Phe Arg His Leu Lys Arg 
            20                  25                  30          


Ile Glu Ala Ala Asn Asp Cys Pro Ala Lys Asn Ser Gly Thr Tyr Gln 
        35                  40                  45              


Lys Val Cys Lys Gln Leu Gln Lys Tyr Tyr Val Leu Thr Pro Asp Asp 
    50                  55                  60                  


Lys Leu Gly Ser Tyr Leu Lys Gly Gly Leu Gln Glu Ala Ala Asn Arg 
65                  70                  75                  80  


Val Leu Thr Pro Val Ser Lys Ser Asp Lys Ile Thr Phe Asp Ile Val 
                85                  90                  95      


Gln Asn Cys Leu Lys Asn Phe Gln Val Met Val Asn Lys His Asn Lys 
            100                 105                 110         


Glu Ala Leu Arg Lys Tyr Arg Glu Cys Lys Lys Glu Cys Phe Thr Glu 
        115                 120                 125             


Val Gly Lys Glu Phe Ser Ser Ala Leu Asp Lys Thr Gly Val Gln Ile 
    130                 135                 140                 


Ala Glu Cys Leu Asn Glu Ser Leu 
145                 150         


<210>  4
<211>  205
<212>  PRT
<213>  Culicoides spec.

<400>  4

Met Arg Phe Ala Thr Ile Phe Leu Leu Ser Ala Ser Ile Ile Leu Leu 
1               5                   10                  15      


Ser Thr Gly Glu Ala Leu Ala Lys Lys Lys Lys Lys Ile Asp Lys Ser 
            20                  25                  30          


Met Pro Pro Glu Cys Leu Pro Leu Pro Pro Lys Lys Arg Ala Ser Glu 
        35                  40                  45              


Cys Thr Asn Gln Ser Gly Phe Lys Tyr Tyr Pro Lys Thr Asn Gln Cys 
    50                  55                  60                  


Gly Pro Val Arg Asn Gln Leu Cys Gln Gly His Gly Gly Phe Thr Thr 
65                  70                  75                  80  


Leu Asp Glu Cys Val Tyr Lys Cys Tyr Asp Tyr Arg Lys Met Ser Thr 
                85                  90                  95      


Thr Lys Asn Val Asp Gly Cys Asn Lys Ser Ile Lys Glu Glu Glu Met 
            100                 105                 110         


Thr Glu Ala Ile Arg Val Val Ser Arg Gly Asp Ser Pro Asp Leu Ile 
        115                 120                 125             


Lys Asp Asn Arg Cys Arg Glu Pro Asn Glu Leu Ser Leu Lys Asn Gly 
    130                 135                 140                 


Ser Ala Arg Val Lys Pro Ala Tyr Lys Phe Asn Lys Asp Thr Asn Glu 
145                 150                 155                 160 


Cys Val Ala Met Met Asp Lys Val Cys Leu Gly Arg Asn Arg Phe Lys 
                165                 170                 175     


Thr Lys Glu Glu Cys Val His Val Cys Asn Trp Asn Leu Ser Ser Gly 
            180                 185                 190         


Arg His Arg His Ile Val Arg Glu Ser Asn Ala Lys Gln 
        195                 200                 205 


<210>  5
<211>  388
<212>  PRT
<213>  Culicoides spec.

<400>  5

Met Trp Ser Ser Val Val Asn Ile Ser His Ile Met Ala Val Val Thr 
1               5                   10                  15      


Thr Ala His Leu Ile Ser Ala Gln His Leu Ile Gln Ala Glu Leu Pro 
            20                  25                  30          


Asp Ser Pro Leu Asn Ile Val Lys Glu Phe Asp Asp Asp Gly Arg Asn 
        35                  40                  45              


Asn Asn Asn Gln Asn Asp Phe Asn Phe Tyr Trp Asn Ile Pro Ser Phe 
    50                  55                  60                  


Met Cys Ala Gln His Asn Ile Thr Phe Thr Asp Met Thr Ser Ser Tyr 
65                  70                  75                  80  


Asn Ile Val Gln Asn Lys Asp Asp Lys Trp Arg Gly Asp Lys Ile Val 
                85                  90                  95      


Ile Leu Tyr Asp Pro Gly Lys Phe Pro Ala Leu Leu Glu His Gln Gly 
            100                 105                 110         


Gln Leu Tyr Arg Arg Asn Gly Gly Val Pro Gln Glu Gly Asn Leu Gln 
        115                 120                 125             


Glu His Ile Asp Ile Leu Ala Glu His Ile Asn Lys Leu Ile Pro Asp 
    130                 135                 140                 


Thr Gln Phe Ser Gly Ile Gly Val Ile Asp Phe Glu Ser Trp Arg Pro 
145                 150                 155                 160 


Ile Phe Arg Gln Asn Ser Gly Val Leu Gln Pro Tyr Lys Asp Leu Ser 
                165                 170                 175     


Tyr Lys Leu Val His Arg Asp His Lys Leu Trp Asn Arg Lys Arg Val 
            180                 185                 190         


Glu Ile Glu Ala Ala Arg Leu Phe Glu Ala Ala Gly Arg Thr Phe Val 
        195                 200                 205             


Glu Glu Thr Ile Asn Val Ala Lys Ile Leu Arg Pro Lys Ala Lys Trp 
    210                 215                 220                 


Gly Tyr Tyr Gly Phe Pro Tyr Cys Phe Asn Met Asn Gly Gly Ala Asn 
225                 230                 235                 240 


Met Asn Glu Asp Cys Pro Ala Asn Val Lys Glu Glu Asn Asp Gln Ile 
                245                 250                 255     


Lys Trp Leu Trp Asp Ile Val Asp Val Val Leu Pro Ser Val Tyr Leu 
            260                 265                 270         


Asn Asn Lys Ile Thr Ser Ala Gln Arg Val Gln Phe Val Arg Gly Arg 
        275                 280                 285             


Met Arg Glu Gly Tyr Arg Val Ala Lys Met Ser Lys Lys Ser Pro Lys 
    290                 295                 300                 


Pro Pro Val Leu Ala Tyr Leu Arg Tyr Val Tyr Thr Asp Thr Leu Lys 
305                 310                 315                 320 


Phe Leu Ser Asn Glu Asp Leu Lys Gln Ala Ile Lys Val Ser Lys Glu 
                325                 330                 335     


Gln Lys Ser Lys Gly Met Ile Phe Trp Gly Ser Ser Tyr Asp Val Lys 
            340                 345                 350         


Thr Lys Glu Gln Cys Ile Asp Phe Arg Lys Tyr Val Asp Asn Asn Leu 
        355                 360                 365             


Gly Pro Ile Val Leu Leu Ala Asn Asn Lys Ser Pro Lys Val Leu Thr 
    370                 375                 380                 


Pro Asn Leu Ala 
385             


<210>  6
<211>  261
<212>  PRT
<213>  Culicoides spec.

<400>  6

Met Phe Arg Ile Cys Leu Phe Thr Val Leu Cys Val Asn Phe Val Val 
1               5                   10                  15      


Ala Thr Asp Phe Cys Asp Arg Lys Leu Cys Arg Arg Gln Ile Glu Pro 
            20                  25                  30          


Asn Val Tyr Gln Asn Ile Pro His Ile Gly Cys Asn His Asp Gly Arg 
        35                  40                  45              


Asn Ser Pro Ala Cys Pro Ser Asp Ala Lys Ile Leu Pro Met Ser Thr 
    50                  55                  60                  


Lys Arg Lys Asn Leu Ile Leu Arg Val His Asn Arg Leu Arg Asn Lys 
65                  70                  75                  80  


Val Ala Leu Gly Gln Leu Pro Gly Tyr Pro Lys Ala Val Arg Met Pro 
                85                  90                  95      


Ile Leu Arg Trp Asp Asp Glu Leu Ala Tyr Leu Ala Glu Leu Asn Val 
            100                 105                 110         


Lys Gln Cys Glu Met Lys His Asp Gln Cys Arg Asn Thr Asp Lys Phe 
        115                 120                 125             


Arg Tyr Ala Gly Gln Asn Leu Ala Tyr Ile Gly Gly Gly Lys Glu Pro 
    130                 135                 140                 


Asn Ala Val Arg Ile Lys Thr Leu Val Arg Ala Trp Phe Asp Glu Tyr 
145                 150                 155                 160 


Lys Asp Ala Asn Ser Ser Phe Ile Asp Lys Tyr Arg Ser His Pro Asn 
                165                 170                 175     


Gly Lys Ala Ile Gly His Phe Thr Ala Met Val Gln Asp Arg Thr Asp 
            180                 185                 190         


Thr Val Gly Cys Ala Ile Leu Arg His Thr Lys Asn Thr Tyr Phe Phe 
        195                 200                 205             


Leu Ala Cys Asn Tyr Ser Phe Thr Asn Met Val Lys Asp Lys Val Tyr 
    210                 215                 220                 


Thr Arg Gly Ala Lys Ser Cys Ser Lys Cys Arg Thr Gly Cys Ser Pro 
225                 230                 235                 240 


Val Tyr Lys Gly Leu Cys Lys Pro His Glu Tyr Val Asn Pro Asp Pro 
                245                 250                 255     


Asp Glu Asp Leu Asp 
            260     


<210>  7
<211>  258
<212>  PRT
<213>  synthetic peptide

<400>  7

Met His His His His His His Tyr Gly Arg Lys Lys Arg Arg Gln Arg 
1               5                   10                  15      


Arg Arg Met Glu Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Val 
            20                  25                  30          


Pro Ile Leu Gly Gln Arg Pro Ala Ala Pro Glu Arg Lys Ser Ser Arg 
        35                  40                  45              


Gly Ala Leu Tyr Thr Gly Phe Ser Val Leu Val Ala Leu Leu Leu Ala 
    50                  55                  60                  


Gly Gln Ala Thr Thr Ala Tyr Phe Leu Phe Gln Gln Gln Gly Arg Leu 
65                  70                  75                  80  


Asp Lys Leu Thr Val Thr Ala Gln Asn Leu Gln Leu Glu Lys Leu Arg 
                85                  90                  95      


Met Lys Leu Pro Lys Ser Ala Lys Pro Val Ser Lys Ile Arg Val Ala 
            100                 105                 110         


Thr Pro Met Leu Met Gln Ala Leu Pro Met Glu Gly Leu Ser His Gly 
        115                 120                 125             


Arg Arg Lys His Phe Arg His Leu Lys Arg Ile Glu Ala Ala Asn Asp 
    130                 135                 140                 


Ser Pro Ala Lys Asn Ser Gly Thr Tyr Gln Lys Val Ser Lys Gln Leu 
145                 150                 155                 160 


Gln Lys Tyr Tyr Val Leu Thr Pro Asp Asp Lys Leu Gly Ser Tyr Leu 
                165                 170                 175     


Lys Gly Gly Leu Gln Glu Ala Ala Asn Arg Val Leu Thr Pro Val Ser 
            180                 185                 190         


Lys Ser Asp Lys Ile Thr Phe Asp Ile Val Gln Asn Ser Leu Lys Asn 
        195                 200                 205             


Phe Gln Val Met Val Asn Lys His Asn Lys Glu Ala Leu Arg Lys Tyr 
    210                 215                 220                 


Arg Glu Ser Lys Lys Glu Ser Phe Thr Glu Val Gly Lys Glu Phe Ser 
225                 230                 235                 240 


Ser Ala Leu Asp Lys Thr Gly Val Gln Ile Ala Glu Ser Leu Asn Glu 
                245                 250                 255     


Ser Leu 
        


<210>  8
<211>  258
<212>  PRT
<213>  synthetic peptide

<400>  8

Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Met Glu Asp Gln 
1               5                   10                  15      


Arg Asp Leu Ile Ser Asn His Glu Gln Val Pro Ile Leu Gly Gln Arg 
            20                  25                  30          


Pro Ala Ala Pro Glu Arg Lys Ser Ser Arg Gly Ala Leu Tyr Thr Gly 
        35                  40                  45              


Phe Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln Ala Thr Thr Ala 
    50                  55                  60                  


Tyr Phe Leu Phe Gln Gln Gln Gly Arg Leu Asp Lys Leu Thr Val Thr 
65                  70                  75                  80  


Ala Gln Asn Leu Gln Leu Glu Lys Leu Arg Met Lys Leu Pro Lys Ser 
                85                  90                  95      


Ala Lys Pro Val Ser Lys Ile Arg Val Ala Thr Pro Met Leu Met Gln 
            100                 105                 110         


Ala Leu Pro Met Glu Gly Leu Ser His Gly Arg Arg Lys His Phe Arg 
        115                 120                 125             


His Leu Lys Arg Ile Glu Ala Ala Asn Asp Ser Pro Ala Lys Asn Ser 
    130                 135                 140                 


Gly Thr Tyr Gln Lys Val Ser Lys Gln Leu Gln Lys Tyr Tyr Val Leu 
145                 150                 155                 160 


Thr Pro Asp Asp Lys Leu Gly Ser Tyr Leu Lys Gly Gly Leu Gln Glu 
                165                 170                 175     


Ala Ala Asn Arg Val Leu Thr Pro Val Ser Lys Ser Asp Lys Ile Thr 
            180                 185                 190         


Phe Asp Ile Val Gln Asn Ser Leu Lys Asn Phe Gln Val Met Val Asn 
        195                 200                 205             


Lys His Asn Lys Glu Ala Leu Arg Lys Tyr Arg Glu Ser Lys Lys Glu 
    210                 215                 220                 


Ser Phe Thr Glu Val Gly Lys Glu Phe Ser Ser Ala Leu Asp Lys Thr 
225                 230                 235                 240 


Gly Val Gln Ile Ala Glu Ser Leu Asn Glu Ser Leu His His His His 
                245                 250                 255     


His His 
        


<210>  9
<211>  310
<212>  PRT
<213>  synthetic peptide

<400>  9

Met His His His His His His Tyr Gly Arg Lys Lys Arg Arg Gln Arg 
1               5                   10                  15      


Arg Arg Met Glu Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Val 
            20                  25                  30          


Pro Ile Leu Gly Gln Arg Pro Ala Ala Pro Glu Arg Lys Ser Ser Arg 
        35                  40                  45              


Gly Ala Leu Tyr Thr Gly Phe Ser Val Leu Val Ala Leu Leu Leu Ala 
    50                  55                  60                  


Gly Gln Ala Thr Thr Ala Tyr Phe Leu Phe Gln Gln Gln Gly Arg Leu 
65                  70                  75                  80  


Asp Lys Leu Thr Val Thr Ala Gln Asn Leu Gln Leu Glu Lys Leu Arg 
                85                  90                  95      


Met Lys Leu Pro Lys Ser Ala Lys Pro Val Ser Lys Ile Arg Val Ala 
            100                 105                 110         


Thr Pro Met Leu Met Gln Ala Leu Pro Met Glu Gly Leu Ser His Gly 
        115                 120                 125             


Lys Lys Lys Lys Lys Ile Asp Lys Ser Met Pro Pro Glu Ser Leu Pro 
    130                 135                 140                 


Leu Pro Pro Lys Lys Arg Ala Ser Glu Ser Thr Asn Gln Ser Gly Phe 
145                 150                 155                 160 


Lys Tyr Tyr Pro Lys Thr Asn Gln Ser Gly Pro Val Arg Asn Gln Leu 
                165                 170                 175     


Ser Gln Gly His Gly Gly Phe Thr Thr Leu Asp Glu Ser Val Tyr Lys 
            180                 185                 190         


Ser Tyr Asp Tyr Arg Lys Met Ser Thr Thr Lys Asn Val Asp Gly Ser 
        195                 200                 205             


Asn Lys Ser Ile Lys Glu Glu Glu Met Thr Glu Ala Ile Arg Val Val 
    210                 215                 220                 


Ser Arg Gly Asp Ser Pro Asp Leu Ile Lys Asp Asn Arg Ser Arg Glu 
225                 230                 235                 240 


Pro Asn Glu Leu Ser Leu Lys Asn Gly Ser Ala Arg Val Lys Pro Ala 
                245                 250                 255     


Tyr Lys Phe Asn Lys Asp Thr Asn Glu Ser Val Ala Met Met Asp Lys 
            260                 265                 270         


Val Ser Leu Gly Arg Asn Arg Phe Lys Thr Lys Glu Glu Ser Val His 
        275                 280                 285             


Val Ser Asn Trp Asn Leu Ser Ser Gly Arg His Arg His Ile Val Arg 
    290                 295                 300                 


Glu Ser Asn Ala Lys Gln 
305                 310 


<210>  10
<211>  310
<212>  PRT
<213>  synthetic peptide

<400>  10

Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Met Glu Asp Gln 
1               5                   10                  15      


Arg Asp Leu Ile Ser Asn His Glu Gln Val Pro Ile Leu Gly Gln Arg 
            20                  25                  30          


Pro Ala Ala Pro Glu Arg Lys Ser Ser Arg Gly Ala Leu Tyr Thr Gly 
        35                  40                  45              


Phe Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln Ala Thr Thr Ala 
    50                  55                  60                  


Tyr Phe Leu Phe Gln Gln Gln Gly Arg Leu Asp Lys Leu Thr Val Thr 
65                  70                  75                  80  


Ala Gln Asn Leu Gln Leu Glu Lys Leu Arg Met Lys Leu Pro Lys Ser 
                85                  90                  95      


Ala Lys Pro Val Ser Lys Ile Arg Val Ala Thr Pro Met Leu Met Gln 
            100                 105                 110         


Ala Leu Pro Met Glu Gly Leu Ser His Gly Lys Lys Lys Lys Lys Ile 
        115                 120                 125             


Asp Lys Ser Met Pro Pro Glu Ser Leu Pro Leu Pro Pro Lys Lys Arg 
    130                 135                 140                 


Ala Ser Glu Ser Thr Asn Gln Ser Gly Phe Lys Tyr Tyr Pro Lys Thr 
145                 150                 155                 160 


Asn Gln Ser Gly Pro Val Arg Asn Gln Leu Ser Gln Gly His Gly Gly 
                165                 170                 175     


Phe Thr Thr Leu Asp Glu Ser Val Tyr Lys Ser Tyr Asp Tyr Arg Lys 
            180                 185                 190         


Met Ser Thr Thr Lys Asn Val Asp Gly Ser Asn Lys Ser Ile Lys Glu 
        195                 200                 205             


Glu Glu Met Thr Glu Ala Ile Arg Val Val Ser Arg Gly Asp Ser Pro 
    210                 215                 220                 


Asp Leu Ile Lys Asp Asn Arg Ser Arg Glu Pro Asn Glu Leu Ser Leu 
225                 230                 235                 240 


Lys Asn Gly Ser Ala Arg Val Lys Pro Ala Tyr Lys Phe Asn Lys Asp 
                245                 250                 255     


Thr Asn Glu Ser Val Ala Met Met Asp Lys Val Ser Leu Gly Arg Asn 
            260                 265                 270         


Arg Phe Lys Thr Lys Glu Glu Ser Val His Val Ser Asn Trp Asn Leu 
        275                 280                 285             


Ser Ser Gly Arg His Arg His Ile Val Arg Glu Ser Asn Ala Lys Gln 
    290                 295                 300                 


His His His His His His 
305                 310 


<210>  11
<211>  493
<212>  PRT
<213>  synthetic peptide

<400>  11

Met His His His His His His Tyr Gly Arg Lys Lys Arg Arg Gln Arg 
1               5                   10                  15      


Arg Arg Met Glu Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Val 
            20                  25                  30          


Pro Ile Leu Gly Gln Arg Pro Ala Ala Pro Glu Arg Lys Ser Ser Arg 
        35                  40                  45              


Gly Ala Leu Tyr Thr Gly Phe Ser Val Leu Val Ala Leu Leu Leu Ala 
    50                  55                  60                  


Gly Gln Ala Thr Thr Ala Tyr Phe Leu Phe Gln Gln Gln Gly Arg Leu 
65                  70                  75                  80  


Asp Lys Leu Thr Val Thr Ala Gln Asn Leu Gln Leu Glu Lys Leu Arg 
                85                  90                  95      


Met Lys Leu Pro Lys Ser Ala Lys Pro Val Ser Lys Ile Arg Val Ala 
            100                 105                 110         


Thr Pro Met Leu Met Gln Ala Leu Pro Met Glu Gly Leu Ser His Gly 
        115                 120                 125             


Gln His Leu Ile Gln Ala Glu Leu Pro Asp Ser Pro Leu Asn Ile Val 
    130                 135                 140                 


Lys Glu Phe Asp Asp Asp Gly Arg Asn Asn Asn Asn Gln Asn Asp Phe 
145                 150                 155                 160 


Asn Phe Tyr Trp Asn Ile Pro Ser Phe Met Ser Ala Gln His Asn Ile 
                165                 170                 175     


Thr Phe Thr Asp Met Thr Ser Ser Tyr Asn Ile Val Gln Asn Lys Asp 
            180                 185                 190         


Asp Lys Trp Arg Gly Asp Lys Ile Val Ile Leu Tyr Asp Pro Gly Lys 
        195                 200                 205             


Phe Pro Ala Leu Leu Glu His Gln Gly Gln Leu Tyr Arg Arg Asn Gly 
    210                 215                 220                 


Gly Val Pro Gln Glu Gly Asn Leu Gln Glu His Ile Asp Ile Leu Ala 
225                 230                 235                 240 


Glu His Ile Asn Lys Leu Ile Pro Asp Thr Gln Phe Ser Gly Ile Gly 
                245                 250                 255     


Val Ile Asp Phe Glu Ser Trp Arg Pro Ile Phe Arg Gln Asn Ser Gly 
            260                 265                 270         


Val Leu Gln Pro Tyr Lys Asp Leu Ser Tyr Lys Leu Val His Arg Asp 
        275                 280                 285             


His Lys Leu Trp Asn Arg Lys Arg Val Glu Ile Glu Ala Ala Arg Leu 
    290                 295                 300                 


Phe Glu Ala Ala Gly Arg Thr Phe Val Glu Glu Thr Ile Asn Val Ala 
305                 310                 315                 320 


Lys Ile Leu Arg Pro Lys Ala Lys Trp Gly Tyr Tyr Gly Phe Pro Tyr 
                325                 330                 335     


Ser Phe Asn Met Asn Gly Gly Ala Asn Met Asn Glu Asp Ser Pro Ala 
            340                 345                 350         


Asn Val Lys Glu Glu Asn Asp Gln Ile Lys Trp Leu Trp Asp Ile Val 
        355                 360                 365             


Asp Val Val Leu Pro Ser Val Tyr Leu Asn Asn Lys Ile Thr Ser Ala 
    370                 375                 380                 


Gln Arg Val Gln Phe Val Arg Gly Arg Met Arg Glu Gly Tyr Arg Val 
385                 390                 395                 400 


Ala Lys Met Ser Lys Lys Ser Pro Lys Pro Pro Val Leu Ala Tyr Leu 
                405                 410                 415     


Arg Tyr Val Tyr Thr Asp Thr Leu Lys Phe Leu Ser Asn Glu Asp Leu 
            420                 425                 430         


Lys Gln Ala Ile Lys Val Ser Lys Glu Gln Lys Ser Lys Gly Met Ile 
        435                 440                 445             


Phe Trp Gly Ser Ser Tyr Asp Val Lys Thr Lys Glu Gln Ser Ile Asp 
    450                 455                 460                 


Phe Arg Lys Tyr Val Asp Asn Asn Leu Gly Pro Ile Val Leu Leu Ala 
465                 470                 475                 480 


Asn Asn Lys Ser Pro Lys Val Leu Thr Pro Asn Leu Ala 
                485                 490             


<210>  12
<211>  493
<212>  PRT
<213>  synthetic peptide

<400>  12

Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Met Glu Asp Gln 
1               5                   10                  15      


Arg Asp Leu Ile Ser Asn His Glu Gln Val Pro Ile Leu Gly Gln Arg 
            20                  25                  30          


Pro Ala Ala Pro Glu Arg Lys Ser Ser Arg Gly Ala Leu Tyr Thr Gly 
        35                  40                  45              


Phe Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln Ala Thr Thr Ala 
    50                  55                  60                  


Tyr Phe Leu Phe Gln Gln Gln Gly Arg Leu Asp Lys Leu Thr Val Thr 
65                  70                  75                  80  


Ala Gln Asn Leu Gln Leu Glu Lys Leu Arg Met Lys Leu Pro Lys Ser 
                85                  90                  95      


Ala Lys Pro Val Ser Lys Ile Arg Val Ala Thr Pro Met Leu Met Gln 
            100                 105                 110         


Ala Leu Pro Met Glu Gly Leu Ser His Gly Gln His Leu Ile Gln Ala 
        115                 120                 125             


Glu Leu Pro Asp Ser Pro Leu Asn Ile Val Lys Glu Phe Asp Asp Asp 
    130                 135                 140                 


Gly Arg Asn Asn Asn Asn Gln Asn Asp Phe Asn Phe Tyr Trp Asn Ile 
145                 150                 155                 160 


Pro Ser Phe Met Ser Ala Gln His Asn Ile Thr Phe Thr Asp Met Thr 
                165                 170                 175     


Ser Ser Tyr Asn Ile Val Gln Asn Lys Asp Asp Lys Trp Arg Gly Asp 
            180                 185                 190         


Lys Ile Val Ile Leu Tyr Asp Pro Gly Lys Phe Pro Ala Leu Leu Glu 
        195                 200                 205             


His Gln Gly Gln Leu Tyr Arg Arg Asn Gly Gly Val Pro Gln Glu Gly 
    210                 215                 220                 


Asn Leu Gln Glu His Ile Asp Ile Leu Ala Glu His Ile Asn Lys Leu 
225                 230                 235                 240 


Ile Pro Asp Thr Gln Phe Ser Gly Ile Gly Val Ile Asp Phe Glu Ser 
                245                 250                 255     


Trp Arg Pro Ile Phe Arg Gln Asn Ser Gly Val Leu Gln Pro Tyr Lys 
            260                 265                 270         


Asp Leu Ser Tyr Lys Leu Val His Arg Asp His Lys Leu Trp Asn Arg 
        275                 280                 285             


Lys Arg Val Glu Ile Glu Ala Ala Arg Leu Phe Glu Ala Ala Gly Arg 
    290                 295                 300                 


Thr Phe Val Glu Glu Thr Ile Asn Val Ala Lys Ile Leu Arg Pro Lys 
305                 310                 315                 320 


Ala Lys Trp Gly Tyr Tyr Gly Phe Pro Tyr Ser Phe Asn Met Asn Gly 
                325                 330                 335     


Gly Ala Asn Met Asn Glu Asp Ser Pro Ala Asn Val Lys Glu Glu Asn 
            340                 345                 350         


Asp Gln Ile Lys Trp Leu Trp Asp Ile Val Asp Val Val Leu Pro Ser 
        355                 360                 365             


Val Tyr Leu Asn Asn Lys Ile Thr Ser Ala Gln Arg Val Gln Phe Val 
    370                 375                 380                 


Arg Gly Arg Met Arg Glu Gly Tyr Arg Val Ala Lys Met Ser Lys Lys 
385                 390                 395                 400 


Ser Pro Lys Pro Pro Val Leu Ala Tyr Leu Arg Tyr Val Tyr Thr Asp 
                405                 410                 415     


Thr Leu Lys Phe Leu Ser Asn Glu Asp Leu Lys Gln Ala Ile Lys Val 
            420                 425                 430         


Ser Lys Glu Gln Lys Ser Lys Gly Met Ile Phe Trp Gly Ser Ser Tyr 
        435                 440                 445             


Asp Val Lys Thr Lys Glu Gln Ser Ile Asp Phe Arg Lys Tyr Val Asp 
    450                 455                 460                 


Asn Asn Leu Gly Pro Ile Val Leu Leu Ala Asn Asn Lys Ser Pro Lys 
465                 470                 475                 480 


Val Leu Thr Pro Asn Leu Ala His His His His His His 
                485                 490             


<210>  13
<211>  372
<212>  PRT
<213>  synthetic peptide

<400>  13

Met His His His His His His Tyr Gly Arg Lys Lys Arg Arg Gln Arg 
1               5                   10                  15      


Arg Arg Met Glu Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Val 
            20                  25                  30          


Pro Ile Leu Gly Gln Arg Pro Ala Ala Pro Glu Arg Lys Ser Ser Arg 
        35                  40                  45              


Gly Ala Leu Tyr Thr Gly Phe Ser Val Leu Val Ala Leu Leu Leu Ala 
    50                  55                  60                  


Gly Gln Ala Thr Thr Ala Tyr Phe Leu Phe Gln Gln Gln Gly Arg Leu 
65                  70                  75                  80  


Asp Lys Leu Thr Val Thr Ala Gln Asn Leu Gln Leu Glu Lys Leu Arg 
                85                  90                  95      


Met Lys Leu Pro Lys Ser Ala Lys Pro Val Ser Lys Ile Arg Val Ala 
            100                 105                 110         


Thr Pro Met Leu Met Gln Ala Leu Pro Met Glu Gly Leu Ser His Gly 
        115                 120                 125             


Thr Asp Phe Ser Asp Arg Lys Leu Ser Arg Arg Gln Ile Glu Pro Asn 
    130                 135                 140                 


Val Tyr Gln Asn Ile Pro His Ile Gly Ser Asn His Asp Gly Arg Asn 
145                 150                 155                 160 


Ser Pro Ala Ser Pro Ser Asp Ala Lys Ile Leu Pro Met Ser Thr Lys 
                165                 170                 175     


Arg Lys Asn Leu Ile Leu Arg Val His Asn Arg Leu Arg Asn Lys Val 
            180                 185                 190         


Ala Leu Gly Gln Leu Pro Gly Tyr Pro Lys Ala Val Arg Met Pro Ile 
        195                 200                 205             


Leu Arg Trp Asp Asp Glu Leu Ala Tyr Leu Ala Glu Leu Asn Val Lys 
    210                 215                 220                 


Gln Ser Glu Met Lys His Asp Gln Ser Arg Asn Thr Asp Lys Phe Arg 
225                 230                 235                 240 


Tyr Ala Gly Gln Asn Leu Ala Tyr Ile Gly Gly Gly Lys Glu Pro Asn 
                245                 250                 255     


Ala Val Arg Ile Lys Thr Leu Val Arg Ala Trp Phe Asp Glu Tyr Lys 
            260                 265                 270         


Asp Ala Asn Ser Ser Phe Ile Asp Lys Tyr Arg Ser His Pro Asn Gly 
        275                 280                 285             


Lys Ala Ile Gly His Phe Thr Ala Met Val Gln Asp Arg Thr Asp Thr 
    290                 295                 300                 


Val Gly Ile Ala Ile Leu Arg His Thr Lys Asn Thr Tyr Phe Phe Leu 
305                 310                 315                 320 


Ala Ile Asn Tyr Ser Phe Thr Asn Met Val Lys Asp Lys Val Tyr Thr 
                325                 330                 335     


Arg Gly Ala Lys Ser Ser Ser Lys Ser Arg Thr Gly Ser Ser Pro Val 
            340                 345                 350         


Tyr Lys Gly Leu Ser Lys Pro His Glu Tyr Val Asn Pro Asp Pro Asp 
        355                 360                 365             


Glu Asp Leu Asp 
    370         


<210>  14
<211>  372
<212>  PRT
<213>  synthetic peptide

<400>  14

Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Met Glu Asp Gln 
1               5                   10                  15      


Arg Asp Leu Ile Ser Asn His Glu Gln Val Pro Ile Leu Gly Gln Arg 
            20                  25                  30          


Pro Ala Ala Pro Glu Arg Lys Ser Ser Arg Gly Ala Leu Tyr Thr Gly 
        35                  40                  45              


Phe Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln Ala Thr Thr Ala 
    50                  55                  60                  


Tyr Phe Leu Phe Gln Gln Gln Gly Arg Leu Asp Lys Leu Thr Val Thr 
65                  70                  75                  80  


Ala Gln Asn Leu Gln Leu Glu Lys Leu Arg Met Lys Leu Pro Lys Ser 
                85                  90                  95      


Ala Lys Pro Val Ser Lys Ile Arg Val Ala Thr Pro Met Leu Met Gln 
            100                 105                 110         


Ala Leu Pro Met Glu Gly Leu Ser His Gly Thr Asp Phe Ser Asp Arg 
        115                 120                 125             


Lys Leu Ser Arg Arg Gln Ile Glu Pro Asn Val Tyr Gln Asn Ile Pro 
    130                 135                 140                 


His Ile Gly Ser Asn His Asp Gly Arg Asn Ser Pro Ala Ser Pro Ser 
145                 150                 155                 160 


Asp Ala Lys Ile Leu Pro Met Ser Thr Lys Arg Lys Asn Leu Ile Leu 
                165                 170                 175     


Arg Val His Asn Arg Leu Arg Asn Lys Val Ala Leu Gly Gln Leu Pro 
            180                 185                 190         


Gly Tyr Pro Lys Ala Val Arg Met Pro Ile Leu Arg Trp Asp Asp Glu 
        195                 200                 205             


Leu Ala Tyr Leu Ala Glu Leu Asn Val Lys Gln Ser Glu Met Lys His 
    210                 215                 220                 


Asp Gln Ser Arg Asn Thr Asp Lys Phe Arg Tyr Ala Gly Gln Asn Leu 
225                 230                 235                 240 


Ala Tyr Ile Gly Gly Gly Lys Glu Pro Asn Ala Val Arg Ile Lys Thr 
                245                 250                 255     


Leu Val Arg Ala Trp Phe Asp Glu Tyr Lys Asp Ala Asn Ser Ser Phe 
            260                 265                 270         


Ile Asp Lys Tyr Arg Ser His Pro Asn Gly Lys Ala Ile Gly His Phe 
        275                 280                 285             


Thr Ala Met Val Gln Asp Arg Thr Asp Thr Val Gly Ile Ala Ile Leu 
    290                 295                 300                 


Arg His Thr Lys Asn Thr Tyr Phe Phe Leu Ala Ile Asn Tyr Ser Phe 
305                 310                 315                 320 


Thr Asn Met Val Lys Asp Lys Val Tyr Thr Arg Gly Ala Lys Ser Ser 
                325                 330                 335     


Ser Lys Ser Arg Thr Gly Ser Ser Pro Val Tyr Lys Gly Leu Ser Lys 
            340                 345                 350         


Pro His Glu Tyr Val Asn Pro Asp Pro Asp Glu Asp Leu Asp His His 
        355                 360                 365             


His His His His 
    370         


<210>  15
<211>  110
<212>  PRT
<213>  equus caballus

<400>  15

Met Glu Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Val Pro Ile 
1               5                   10                  15      


Leu Gly Gln Arg Pro Ala Ala Pro Glu Arg Lys Cys Ser Arg Gly Ala 
            20                  25                  30          


Leu Tyr Thr Gly Phe Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln 
        35                  40                  45              


Ala Thr Thr Ala Tyr Phe Leu Phe Gln Gln Gln Gly Arg Leu Asp Lys 
    50                  55                  60                  


Leu Thr Val Thr Ala Gln Asn Leu Gln Leu Glu Lys Leu Arg Met Lys 
65                  70                  75                  80  


Leu Pro Lys Ser Ala Lys Pro Val Ser Lys Ile Arg Val Ala Thr Pro 
                85                  90                  95      


Met Leu Met Gln Ala Leu Pro Met Glu Gly Leu Ser His Gly 
            100                 105                 110 


<210>  16
<211>  110
<212>  PRT
<213>  synthetic peptide

<400>  16

Met Glu Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Val Pro Ile 
1               5                   10                  15      


Leu Gly Gln Arg Pro Ala Ala Pro Glu Arg Lys Ser Ser Arg Gly Ala 
            20                  25                  30          


Leu Tyr Thr Gly Phe Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln 
        35                  40                  45              


Ala Thr Thr Ala Tyr Phe Leu Phe Gln Gln Gln Gly Arg Leu Asp Lys 
    50                  55                  60                  


Leu Thr Val Thr Ala Gln Asn Leu Gln Leu Glu Lys Leu Arg Met Lys 
65                  70                  75                  80  


Leu Pro Lys Ser Ala Lys Pro Val Ser Lys Ile Arg Val Ala Thr Pro 
                85                  90                  95      


Met Leu Met Gln Ala Leu Pro Met Glu Gly Leu Ser His Gly 
            100                 105                 110 


<210>  17
<211>  333
<212>  PRT
<213>  synthetic peptide

<400>  17

Met His His His His His His Tyr Gly Arg Lys Lys Arg Arg Gln Arg 
1               5                   10                  15      


Arg Arg Met Glu Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Val 
            20                  25                  30          


Pro Ile Leu Gly Gln Arg Pro Ala Ala Pro Glu Arg Lys Ser Ser Arg 
        35                  40                  45              


Gly Ala Leu Tyr Thr Gly Phe Ser Val Leu Val Ala Leu Leu Leu Ala 
    50                  55                  60                  


Gly Gln Ala Thr Thr Ala Tyr Phe Leu Phe Gln Gln Gln Gly Arg Leu 
65                  70                  75                  80  


Asp Lys Leu Thr Val Thr Ala Gln Asn Leu Gln Leu Glu Lys Leu Arg 
                85                  90                  95      


Met Lys Leu Pro Lys Ser Ala Lys Pro Val Ser Lys Ile Arg Val Ala 
            100                 105                 110         


Thr Pro Met Leu Met Gln Ala Leu Pro Met Glu Gly Leu Ser His Gly 
        115                 120                 125             


Ala Arg Val Lys Lys Asn Asp Pro Leu Pro Gly Ala Thr Val Gly Gly 
    130                 135                 140                 


Tyr Ser Gly Gly Asp Leu Val Ser Glu Arg Ala Ser Val Ser Val Lys 
145                 150                 155                 160 


Lys Gly Gly Tyr Lys Tyr Asn Ala Gln Ala Asn Arg Ser Val Tyr Asp 
                165                 170                 175     


Ser Arg Asn Phe Asp Pro Gly Lys Glu Phe Leu Lys Leu Val Leu Tyr 
            180                 185                 190         


Phe Lys Ser Lys Asp Phe Lys Asn Arg Lys Trp Asp Glu Arg Glu Lys 
        195                 200                 205             


Asn Asn Lys Asn Met Asp Pro Val Lys Asn Gln Ala Gln Ser Gly Ser 
    210                 215                 220                 


Ser Trp Ala Phe Ala Pro Val Pro Ser Arg Ser Tyr Thr Leu Ala Glu 
225                 230                 235                 240 


Gln Glu Leu Val Asp Ser Glu Thr Thr Ser Ile Lys Gly Leu Lys Met 
                245                 250                 255     


Ser Ala Arg Arg Ser Leu Asn Pro Arg Leu Gly Phe Arg Gly Gly Trp 
            260                 265                 270         


Ser Thr Thr Gly Asn Thr Leu Ser Asn Val Ser Leu Gly Arg Asn Arg 
        275                 280                 285             


Phe Ser Ser Gln Asp Glu Leu Ile His Val Ile Val Trp Asn Lys Gly 
    290                 295                 300                 


Ser Gly Arg Val Arg His Val Ala Arg Ala Glu Asn Ala Ala Glu Asn 
305                 310                 315                 320 


Lys Ile Lys Ala Ala Gly Gly Ala Ser Val Leu Arg Ala 
                325                 330             


<210>  18
<211>  273
<212>  PRT
<213>  Culicoides spec.

<400>  18

Met Asn Ile Lys Ser Thr Ile Ile Val Ile Ala Ile Ile Ser Ala Val 
1               5                   10                  15      


Tyr Ala Ala Asp His Gln Ser Gln Lys Ala Val Ala Val Pro Ser Tyr 
            20                  25                  30          


Thr Tyr Arg Arg Pro Ser Thr Lys Ile Ile Gly Gly Ala Pro Ala Phe 
        35                  40                  45              


Ser His Gln Phe Pro Trp Gln Ala Ser Ile Thr Val Thr Ala Cys Ser 
    50                  55                  60                  


Gly Asp Trp Cys Ser Leu Cys Gly Gly Ser Leu Ile Ser Arg Lys His 
65                  70                  75                  80  


Val Leu Thr Ala Ala His Cys Thr Lys Gly Leu Ser Ser Phe Thr Ile 
                85                  90                  95      


Gly Leu Gly Ser Asn Thr Arg Asn Arg Pro Ala Val Thr Val Val Ala 
            100                 105                 110         


Lys Ser Lys Thr Glu His Pro Lys Tyr Asn Pro Glu Ser Leu Ala Asn 
        115                 120                 125             


Asp Val Ser Ile Ile Thr Leu Ser Leu Asn Val Asn Leu Asn Asn Asn 
    130                 135                 140                 


Ile Lys Val Ile Ser Leu Ala Asn Ser Gly Ile Gly Thr Leu Val Asn 
145                 150                 155                 160 


Arg Asn Ala Phe Val Ser Gly Tyr Gly Lys Thr Ser Ser Ser Ser Glu 
                165                 170                 175     


Gly Ser Asn Thr Leu Asn Tyr Leu Ser Met Arg Leu Ile Ser Asn Ser 
            180                 185                 190         


Asp Cys Tyr Lys Val Phe Gly Pro Gln Ile Tyr Ser Thr Thr Leu Cys 
        195                 200                 205             


Ala Val Ala Arg Ser Ser Val His Lys Asn Val Cys Ser Gly Asp Ser 
    210                 215                 220                 


Gly Gly Pro Leu Val Ile Lys Arg Asn Gly Asn Tyr Val Gln Val Gly 
225                 230                 235                 240 


Ile Val Ser Phe Val Ala Lys Val Gly Cys Asp Ala Gly Phe Pro Ser 
                245                 250                 255     


Gly Tyr Ala Arg Val Ser Ser Phe Arg Asn Trp Ile Thr Gln Asn Met 
            260                 265                 270         


Asn 
    


<210>  19
<211>  159
<212>  PRT
<213>  Culicoides spec.

<400>  19

Met Lys Phe Ser Val Ser Lys Leu Ser Leu Leu Leu Cys Ile Thr Ile 
1               5                   10                  15      


Leu Cys Ile Cys Phe Ala Thr Ala Ala Pro Gln Trp Gln Ile Ser Glu 
            20                  25                  30          


Leu Ser Glu Gln Ser Asn Val Ile Lys Cys Ser Asn Glu Asn Asn Phe 
        35                  40                  45              


Gly Ile Tyr Lys Glu Leu Cys Gln Phe Leu Lys Lys Ile Tyr Ile Lys 
    50                  55                  60                  


Ala Pro Asp Glu Asp Leu Gly Ser Tyr Leu Arg Gly Gly Leu Gln Ser 
65                  70                  75                  80  


Ala Ala Asn Arg Leu Leu Asp Pro Thr Val Thr Leu Pro Lys Asn Thr 
                85                  90                  95      


Leu Lys Asn Val Glu Asp Cys Met Lys Asn Phe Gln Ala Val Ile Asn 
            100                 105                 110         


Glu Tyr Asn Val Val Ala Leu Lys Lys Tyr Gln Glu Cys Asp Gly Gln 
        115                 120                 125             


Cys Ala Lys Gln Ala Gly Gln Leu Phe Glu Asn Asp Ala Ser Lys Thr 
    130                 135                 140                 


Ala Gly Arg Met Gly Asp Cys Ile Val Ser Leu Ala Ala Leu His 
145                 150                 155                 


<210>  20
<211>  383
<212>  PRT
<213>  synthetic peptide

<400>  20

Met His His His His His His Tyr Gly Arg Lys Lys Arg Arg Gln Arg 
1               5                   10                  15      


Arg Arg Met Glu Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Val 
            20                  25                  30          


Pro Ile Leu Gly Gln Arg Pro Ala Ala Pro Glu Arg Lys Ser Ser Arg 
        35                  40                  45              


Gly Ala Leu Tyr Thr Gly Phe Ser Val Leu Val Ala Leu Leu Leu Ala 
    50                  55                  60                  


Gly Gln Ala Thr Thr Ala Tyr Phe Leu Phe Gln Gln Gln Gly Arg Leu 
65                  70                  75                  80  


Asp Lys Leu Thr Val Thr Ala Gln Asn Leu Gln Leu Glu Lys Leu Arg 
                85                  90                  95      


Met Lys Leu Pro Lys Ser Ala Lys Pro Val Ser Lys Ile Arg Val Ala 
            100                 105                 110         


Thr Pro Met Leu Met Gln Ala Leu Pro Met Glu Gly Leu Ser His Gly 
        115                 120                 125             


Ala Asp His Gln Ser Gln Lys Ala Val Ala Val Pro Ser Tyr Thr Tyr 
    130                 135                 140                 


Arg Arg Pro Ser Thr Lys Ile Ile Gly Gly Ala Pro Ala Phe Ser His 
145                 150                 155                 160 


Gln Phe Pro Trp Gln Ala Ser Ile Thr Val Thr Ala Ser Ser Gly Asp 
                165                 170                 175     


Trp Ser Ser Leu Ser Gly Gly Ser Leu Ile Ser Arg Lys His Val Leu 
            180                 185                 190         


Thr Ala Ala His Ser Thr Lys Gly Leu Ser Ser Phe Thr Ile Gly Leu 
        195                 200                 205             


Gly Ser Asn Thr Arg Asn Arg Pro Ala Val Thr Val Val Ala Lys Ser 
    210                 215                 220                 


Lys Thr Glu His Pro Lys Tyr Asn Pro Glu Ser Leu Ala Asn Asp Val 
225                 230                 235                 240 


Ser Ile Ile Thr Leu Ser Leu Asn Val Asn Leu Asn Asn Asn Ile Lys 
                245                 250                 255     


Val Ile Ser Leu Ala Asn Ser Gly Ile Gly Thr Leu Val Asn Arg Asn 
            260                 265                 270         


Ala Phe Val Ser Gly Tyr Gly Lys Thr Ser Ser Ser Ser Glu Gly Ser 
        275                 280                 285             


Asn Thr Leu Asn Tyr Leu Ser Met Arg Leu Ile Ser Asn Ser Asp Ser 
    290                 295                 300                 


Tyr Lys Val Phe Gly Pro Gln Ile Tyr Ser Thr Thr Leu Ser Ala Val 
305                 310                 315                 320 


Ala Arg Ser Ser Val His Lys Asn Val Ser Ser Gly Asp Ser Gly Gly 
                325                 330                 335     


Pro Leu Val Ile Lys Arg Asn Gly Asn Tyr Val Gln Val Gly Ile Val 
            340                 345                 350         


Ser Phe Val Ala Lys Val Gly Ser Asp Ala Gly Phe Pro Ser Gly Tyr 
        355                 360                 365             


Ala Arg Val Ser Ser Phe Arg Asn Trp Ile Thr Gln Asn Met Asn 
    370                 375                 380             


<210>  21
<211>  383
<212>  PRT
<213>  synthetic peptide

<400>  21

Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Met Glu Asp Gln 
1               5                   10                  15      


Arg Asp Leu Ile Ser Asn His Glu Gln Val Pro Ile Leu Gly Gln Arg 
            20                  25                  30          


Pro Ala Ala Pro Glu Arg Lys Ser Ser Arg Gly Ala Leu Tyr Thr Gly 
        35                  40                  45              


Phe Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln Ala Thr Thr Ala 
    50                  55                  60                  


Tyr Phe Leu Phe Gln Gln Gln Gly Arg Leu Asp Lys Leu Thr Val Thr 
65                  70                  75                  80  


Ala Gln Asn Leu Gln Leu Glu Lys Leu Arg Met Lys Leu Pro Lys Ser 
                85                  90                  95      


Ala Lys Pro Val Ser Lys Ile Arg Val Ala Thr Pro Met Leu Met Gln 
            100                 105                 110         


Ala Leu Pro Met Glu Gly Leu Ser His Gly Ala Asp His Gln Ser Gln 
        115                 120                 125             


Lys Ala Val Ala Val Pro Ser Tyr Thr Tyr Arg Arg Pro Ser Thr Lys 
    130                 135                 140                 


Ile Ile Gly Gly Ala Pro Ala Phe Ser His Gln Phe Pro Trp Gln Ala 
145                 150                 155                 160 


Ser Ile Thr Val Thr Ala Ser Ser Gly Asp Trp Ser Ser Leu Ser Gly 
                165                 170                 175     


Gly Ser Leu Ile Ser Arg Lys His Val Leu Thr Ala Ala His Ser Thr 
            180                 185                 190         


Lys Gly Leu Ser Ser Phe Thr Ile Gly Leu Gly Ser Asn Thr Arg Asn 
        195                 200                 205             


Arg Pro Ala Val Thr Val Val Ala Lys Ser Lys Thr Glu His Pro Lys 
    210                 215                 220                 


Tyr Asn Pro Glu Ser Leu Ala Asn Asp Val Ser Ile Ile Thr Leu Ser 
225                 230                 235                 240 


Leu Asn Val Asn Leu Asn Asn Asn Ile Lys Val Ile Ser Leu Ala Asn 
                245                 250                 255     


Ser Gly Ile Gly Thr Leu Val Asn Arg Asn Ala Phe Val Ser Gly Tyr 
            260                 265                 270         


Gly Lys Thr Ser Ser Ser Ser Glu Gly Ser Asn Thr Leu Asn Tyr Leu 
        275                 280                 285             


Ser Met Arg Leu Ile Ser Asn Ser Asp Ser Tyr Lys Val Phe Gly Pro 
    290                 295                 300                 


Gln Ile Tyr Ser Thr Thr Leu Ser Ala Val Ala Arg Ser Ser Val His 
305                 310                 315                 320 


Lys Asn Val Ser Ser Gly Asp Ser Gly Gly Pro Leu Val Ile Lys Arg 
                325                 330                 335     


Asn Gly Asn Tyr Val Gln Val Gly Ile Val Ser Phe Val Ala Lys Val 
            340                 345                 350         


Gly Ser Asp Ala Gly Phe Pro Ser Gly Tyr Ala Arg Val Ser Ser Phe 
        355                 360                 365             


Arg Asn Trp Ile Thr Gln Asn Met Asn His His His His His His 
    370                 375                 380             


<210>  22
<211>  263
<212>  PRT
<213>  synthetic peptide

<400>  22

Met His His His His His His Tyr Gly Arg Lys Lys Arg Arg Gln Arg 
1               5                   10                  15      


Arg Arg Met Glu Asp Gln Arg Asp Leu Ile Ser Asn His Glu Gln Val 
            20                  25                  30          


Pro Ile Leu Gly Gln Arg Pro Ala Ala Pro Glu Arg Lys Ser Ser Arg 
        35                  40                  45              


Gly Ala Leu Tyr Thr Gly Phe Ser Val Leu Val Ala Leu Leu Leu Ala 
    50                  55                  60                  


Gly Gln Ala Thr Thr Ala Tyr Phe Leu Phe Gln Gln Gln Gly Arg Leu 
65                  70                  75                  80  


Asp Lys Leu Thr Val Thr Ala Gln Asn Leu Gln Leu Glu Lys Leu Arg 
                85                  90                  95      


Met Lys Leu Pro Lys Ser Ala Lys Pro Val Ser Lys Ile Arg Val Ala 
            100                 105                 110         


Thr Pro Met Leu Met Gln Ala Leu Pro Met Glu Gly Leu Ser His Gly 
        115                 120                 125             


Ala Pro Gln Trp Gln Ile Ser Glu Leu Ser Glu Gln Ser Asn Val Ile 
    130                 135                 140                 


Lys Ser Ser Asn Glu Asn Asn Phe Gly Ile Tyr Lys Glu Leu Ser Gln 
145                 150                 155                 160 


Phe Leu Lys Lys Ile Tyr Ile Lys Ala Pro Asp Glu Asp Leu Gly Ser 
                165                 170                 175     


Tyr Leu Arg Gly Gly Leu Gln Ser Ala Ala Asn Arg Leu Leu Asp Pro 
            180                 185                 190         


Thr Val Thr Leu Pro Lys Asn Thr Leu Lys Asn Val Glu Asp Ser Met 
        195                 200                 205             


Lys Asn Phe Gln Ala Val Ile Asn Glu Tyr Asn Val Val Ala Leu Lys 
    210                 215                 220                 


Lys Tyr Gln Glu Ser Asp Gly Gln Ser Ala Lys Gln Ala Gly Gln Leu 
225                 230                 235                 240 


Phe Glu Asn Asp Ala Ser Lys Thr Ala Gly Arg Met Gly Asp Ser Ile 
                245                 250                 255     


Val Ser Leu Ala Ala Leu His 
            260             


<210>  23
<211>  263
<212>  PRT
<213>  synthetic peptide

<400>  23

Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Met Glu Asp Gln 
1               5                   10                  15      


Arg Asp Leu Ile Ser Asn His Glu Gln Val Pro Ile Leu Gly Gln Arg 
            20                  25                  30          


Pro Ala Ala Pro Glu Arg Lys Ser Ser Arg Gly Ala Leu Tyr Thr Gly 
        35                  40                  45              


Phe Ser Val Leu Val Ala Leu Leu Leu Ala Gly Gln Ala Thr Thr Ala 
    50                  55                  60                  


Tyr Phe Leu Phe Gln Gln Gln Gly Arg Leu Asp Lys Leu Thr Val Thr 
65                  70                  75                  80  


Ala Gln Asn Leu Gln Leu Glu Lys Leu Arg Met Lys Leu Pro Lys Ser 
                85                  90                  95      


Ala Lys Pro Val Ser Lys Ile Arg Val Ala Thr Pro Met Leu Met Gln 
            100                 105                 110         


Ala Leu Pro Met Glu Gly Leu Ser His Gly Ala Pro Gln Trp Gln Ile 
        115                 120                 125             


Ser Glu Leu Ser Glu Gln Ser Asn Val Ile Lys Ser Ser Asn Glu Asn 
    130                 135                 140                 


Asn Phe Gly Ile Tyr Lys Glu Leu Ser Gln Phe Leu Lys Lys Ile Tyr 
145                 150                 155                 160 


Ile Lys Ala Pro Asp Glu Asp Leu Gly Ser Tyr Leu Arg Gly Gly Leu 
                165                 170                 175     


Gln Ser Ala Ala Asn Arg Leu Leu Asp Pro Thr Val Thr Leu Pro Lys 
            180                 185                 190         


Asn Thr Leu Lys Asn Val Glu Asp Ser Met Lys Asn Phe Gln Ala Val 
        195                 200                 205             


Ile Asn Glu Tyr Asn Val Val Ala Leu Lys Lys Tyr Gln Glu Ser Asp 
    210                 215                 220                 


Gly Gln Ser Ala Lys Gln Ala Gly Gln Leu Phe Glu Asn Asp Ala Ser 
225                 230                 235                 240 


Lys Thr Ala Gly Arg Met Gly Asp Ser Ile Val Ser Leu Ala Ala Leu 
                245                 250                 255     


His His His His His His His 
            260             


