                         SEQUENCE LISTING

<110>  IMMCO
 
<120>  IMPROVED ANTI-NUCLEAR ANTIBODY DETECTION AND DIAGNOSTICS FOR 
       SYSTEMIC AND NON-SYSTEMIC AUTOIMMUNE DISORDERS

<130>  019657.00056

<150>  61/969,771
<151>  2014-03-24

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  530
<212>  PRT
<213>  Homo sapien

<400>  1

Met Thr Arg Asp Phe Lys Pro Gly Asp Leu Ile Phe Ala Lys Met Lys 
1               5                   10                  15      


Gly Tyr Pro His Trp Pro Ala Arg Val Asp Glu Val Pro Asp Gly Ala 
            20                  25                  30          


Val Lys Pro Pro Thr Asn Lys Leu Pro Ile Phe Phe Phe Gly Thr His 
        35                  40                  45              


Glu Thr Ala Phe Leu Gly Pro Lys Asp Ile Phe Pro Tyr Ser Glu Asn 
    50                  55                  60                  


Lys Glu Lys Tyr Gly Lys Pro Asn Lys Arg Lys Gly Phe Asn Glu Gly 
65                  70                  75                  80  


Leu Trp Glu Ile Asp Asn Asn Pro Lys Val Lys Phe Ser Ser Gln Gln 
                85                  90                  95      


Ala Ala Thr Lys Gln Ser Asn Ala Ser Ser Asp Val Glu Val Glu Glu 
            100                 105                 110         


Lys Glu Thr Ser Val Ser Lys Glu Asp Thr Asp His Glu Glu Lys Ala 
        115                 120                 125             


Ser Asn Glu Asp Val Thr Lys Ala Val Asp Ile Thr Thr Pro Lys Ala 
    130                 135                 140                 


Ala Arg Arg Gly Arg Lys Arg Lys Ala Glu Lys Gln Val Glu Thr Glu 
145                 150                 155                 160 


Glu Ala Gly Val Val Thr Thr Ala Thr Ala Ser Val Asn Leu Lys Val 
                165                 170                 175     


Ser Pro Lys Arg Gly Arg Pro Ala Ala Thr Glu Val Lys Ile Pro Lys 
            180                 185                 190         


Pro Arg Gly Arg Pro Lys Met Val Lys Gln Pro Cys Pro Ser Glu Ser 
        195                 200                 205             


Asp Ile Ile Thr Glu Glu Asp Lys Ser Lys Lys Lys Gly Gln Glu Glu 
    210                 215                 220                 


Lys Gln Pro Lys Lys Gln Pro Lys Lys Asp Glu Glu Gly Gln Lys Glu 
225                 230                 235                 240 


Glu Asp Lys Pro Arg Lys Glu Pro Asp Lys Lys Glu Gly Lys Lys Glu 
                245                 250                 255     


Val Glu Ser Lys Arg Lys Asn Leu Ala Lys Thr Gly Val Thr Ser Thr 
            260                 265                 270         


Ser Asp Ser Glu Glu Glu Gly Asp Asp Gln Glu Gly Glu Lys Lys Arg 
        275                 280                 285             


Lys Gly Gly Arg Asn Phe Gln Thr Ala His Arg Arg Asn Met Leu Lys 
    290                 295                 300                 


Gly Gln His Glu Lys Glu Ala Ala Asp Arg Lys Arg Lys Gln Glu Glu 
305                 310                 315                 320 


Gln Met Glu Thr Glu Gln Gln Asn Lys Asp Glu Gly Lys Lys Pro Glu 
                325                 330                 335     


Val Lys Lys Val Glu Lys Lys Arg Glu Thr Ser Met Asp Ser Arg Leu 
            340                 345                 350         


Gln Arg Ile His Ala Glu Ile Lys Asn Ser Leu Lys Ile Asp Asn Leu 
        355                 360                 365             


Asp Val Asn Arg Cys Ile Glu Ala Leu Asp Glu Leu Ala Ser Leu Gln 
    370                 375                 380                 


Val Thr Met Gln Gln Ala Gln Lys His Thr Glu Met Ile Thr Thr Leu 
385                 390                 395                 400 


Lys Lys Ile Arg Arg Phe Lys Val Ser Gln Val Ile Met Glu Lys Ser 
                405                 410                 415     


Thr Met Leu Tyr Asn Lys Phe Lys Asn Met Phe Leu Val Gly Glu Gly 
            420                 425                 430         


Asp Ser Val Ile Thr Gln Val Leu Asn Lys Ser Leu Ala Glu Gln Arg 
        435                 440                 445             


Gln His Glu Glu Ala Asn Lys Thr Lys Asp Gln Gly Lys Lys Gly Pro 
    450                 455                 460                 


Asn Lys Lys Leu Glu Lys Glu Gln Thr Gly Ser Lys Thr Leu Asn Gly 
465                 470                 475                 480 


Gly Ser Asp Ala Gln Asp Gly Asn Gln Pro Gln His Asn Gly Glu Ser 
                485                 490                 495     


Asn Glu Asp Ser Lys Asp Asn His Glu Ala Ser Thr Lys Lys Lys Pro 
            500                 505                 510         


Ser Ser Glu Glu Arg Glu Thr Glu Ile Ser Leu Lys Asp Ser Thr Leu 
        515                 520                 525             


Asp Asn 
    530 


<210>  2
<211>  107
<212>  PRT
<213>  Homo sapien

<400>  2

Asp Ser Arg Leu Gln Arg Ile His Ala Glu Ile Lys Asn Ser Leu Lys 
1               5                   10                  15      


Ile Asp Asn Leu Asp Val Asn Arg Cys Ile Glu Ala Leu Asp Glu Leu 
            20                  25                  30          


Ala Ser Leu Gln Val Thr Met Gln Gln Ala Gln Lys His Thr Glu Met 
        35                  40                  45              


Ile Thr Thr Leu Lys Lys Ile Arg Arg Phe Lys Val Ser Gln Val Ile 
    50                  55                  60                  


Met Glu Lys Ser Thr Met Leu Tyr Asn Lys Phe Lys Asn Met Phe Leu 
65                  70                  75                  80  


Val Gly Glu Gly Asp Ser Val Ile Thr Gln Val Leu Asn Lys Ser Leu 
                85                  90                  95      


Ala Glu Gln Arg Gln His Glu Glu Ala Asn Lys 
            100                 105         


<210>  3
<211>  1593
<212>  DNA
<213>  Homo sapien

<400>  3
atgactcgcg atttcaaacc tggagacctc atcttcgcca agatgaaagg ttatccccat       60

tggccagctc gagtagacga agttcctgat ggagctgtaa agccacccac aaacaaacta      120

cccattttct tttttggaac tcatgagact gcttttttag gaccaaagga tatatttcct      180

tactcagaaa ataaggaaaa gtatggcaaa ccaaataaaa gaaaaggttt taatgaaggt      240

ttatgggaga tagataacaa tccaaaagtg aaattttcaa gtcaacaggc agcaactaaa      300

caatcaaatg catcatctga tgttgaagtt gaagaaaagg aaactagtgt ttcaaaggaa      360

gataccgacc atgaagaaaa agccagcaat gaggatgtga ctaaagcagt tgacataact      420

actccaaaag ctgccagaag ggggagaaag agaaaggcag aaaaacaagt agaaactgag      480

gaggcaggag tagtgacaac agcaacagca tctgttaatc taaaagtgag tcctaaaaga      540

ggacgacctg cagctacaga agtcaagatt ccaaaaccaa gaggcagacc caaaatggta      600

aaacagccct gtccttcaga gagtgacatc attactgaag aggacaaaag taagaaaaag      660

gggcaagagg aaaaacaacc taaaaagcag cctaagaagg atgaagaggg ccagaaggaa      720

gaagataagc caagaaaaga gccggataaa aaagagggga agaaagaagt tgaatcaaaa      780

aggaaaaatt tagctaaaac aggggttact tcaacctccg attctgaaga agaaggagat      840

gatcaagaag gtgaaaagaa gagaaaaggt gggaggaact ttcagactgc tcacagaagg      900

aatatgctga aaggccaaca tgagaaagaa gcagcagatc gaaaacgcaa gcaagaggaa      960

caaatggaaa ctgagcagca gaataaagat gaaggaaaga agccagaagt taagaaagtg     1020

gagaagaagc gagaaacatc aatggattct cgacttcaaa ggatacatgc tgagattaaa     1080

aattcactca aaattgataa tcttgatgtg aacagatgca ttgaggcctt ggatgaactt     1140

gcttcacttc aggtcacaat gcaacaagct cagaaacaca cagagatgat tactacactg     1200

aaaaaaatac ggcgattcaa agttagtcag gtaatcatgg aaaagtctac aatgttgtat     1260

aacaagttta agaacatgtt cttggttggt gaaggagatt ccgtgatcac ccaagtgctg     1320

aataaatctc ttgctgaaca aagacagcat gaggaagcga ataaaaccaa agatcaaggg     1380

aagaaagggc caaacaaaaa gctagagaag gaacaaacag ggtcaaagac tctaaatgga     1440

ggatctgatg ctcaagatgg taatcagcca caacataacg gggagagcaa tgaagacagc     1500

aaagacaacc atgaagccag cacgaagaaa aagccatcca gtgaagagag agagactgaa     1560

atatctctga aggattctac actagataac tag                                  1593


<210>  4
<211>  19
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA equivalent of shRNA sequences

<400>  4
agacagcatg aggaagcga                                                    19


<210>  5
<211>  47
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA equivalent of shRNA sequences

<400>  5
agacagcatg aggaagcgat tcaagagatc gcttcctcat gctgtct                     47


<210>  6
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA equivalent of shRNA sequences

<400>  6
agttcctgat ggagctgtaa a                                                 21


<210>  7
<211>  46
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA equivalent of shRNA sequences

<400>  7
agttcctgat ggagctgtaa acgagtttac agctccatca ggaact                      46


<210>  8
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA equivalent of shRNA sequences

<400>  8
gcaatgaaga cagcaaagac a                                                 21


<210>  9
<211>  46
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA equivalent of shRNA sequences

<400>  9
gcaatgaaga cagcaaagac acgagtgtct ttgctgtctt cattgc                      46


<210>  10
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA equivalent of shRNA sequences

<400>  10
gtctccacgc gcagtacatt t                                                 21


<210>  11
<211>  46
<212>  DNA
<213>  artificial sequence

<220>
<223>  DNA equivalent of shRNA sequences

<400>  11
gtctccacgc gcagtacatt tcgagaaatg tactgcgcgt ggagac                      46


<210>  12
<211>  454
<212>  DNA
<213>  Homo sapien

<400>  12
gtacaaaaaa gcaggcttta aaggaaccaa ttcagtcgac tggatccggt accaaggtcg       60

ggcaggaaga gggcctattt cccatgattc cttcatattt gcatatacga tacaaggctg      120

ttagagagat aattagaatt aatttgactg taaacacaaa gatattagta caaaatacgt      180

gacgtagaaa gtaataattt cttgggtagt ttgcagtttt aaaattatgt tttaaaatgg      240

actatcatat gcttaccgta acttgaaagt atttcgattt cttggcttta tatatcttgt      300

ggaaaggacg aaacaccgta atcagccaca acataacgtt ttagagctag aaatagcaag      360

ttaaaataag gctagtccgt tatcaacttg aaaaagtggc accgagtcgg tgcttttttt      420

ctagacccag ctttcttgta caaagttggc atta                                  454


<210>  13
<211>  455
<212>  DNA
<213>  Homo sapien

<400>  13
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccga cgcctctgcg gcagctgggt tttagagcta gaaatagcaa      360

gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg gtgctttttt      420

tctagaccca gctttcttgt acaaagttgg catta                                 455


<210>  14
<211>  455
<212>  DNA
<213>  Homo sapien

<400>  14
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccga ggtagacgaa gttcctgagt tttagagcta gaaatagcaa      360

gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg gtgctttttt      420

tctagaccca gctttcttgt acaaagttgg catta                                 455


<210>  15
<211>  455
<212>  DNA
<213>  Homo sapien

<400>  15
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccga actacccatt ttctttttgt tttagagcta gaaatagcaa      360

gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg gtgctttttt      420

tctagaccca gctttcttgt acaaagttgg catta                                 455


<210>  16
<211>  455
<212>  DNA
<213>  Homo sapien

<400>  16
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacaccga gtgctttttt aggaccaagt tttagagcta gaaatagcaa      360

gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg gtgctttttt      420

tctagaccca gctttcttgt acaaagttgg catta                                 455


