                               SEQUENCE LISTING

<110> SHIRE HUMAN GENETIC THERAPIES, INC.
 
<120> MRNA THERAPY FOR TREATMENT OF OCULAR DISEASES

<130> 2006685-0854

<140>
<141>

<150> 61/969,483
<151> 2014-03-24

<160> 8     

<170> PatentIn version 3.5

<210> 1
<211> 1899
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (1794)..(1794)
<223> May or may not be present

<220>
<221> modified_base
<222> (1896)..(1896)
<223> May or may not be present

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 1
ggacagaucg ccuggagacg ccauccacgc uguuuugacc uccauagaag acaccgggac       60

cgauccagcc uccgcggccg ggaacggugc auuggaacgc ggauuccccg ugccaagagu      120

gacucaccgu ccuugacacg auggaagaug ccaaaaacau uaagaagggc ccagcgccau      180

ucuacccacu cgaagacggg accgccggcg agcagcugca caaagccaug aagcgcuacg      240

cccuggugcc cggcaccauc gccuuuaccg acgcacauau cgagguggac auuaccuacg      300

ccgaguacuu cgagaugagc guucggcugg cagaagcuau gaagcgcuau gggcugaaua      360

caaaccaucg gaucguggug ugcagcgaga auagcuugca guucuucaug cccguguugg      420

gugcccuguu caucggugug gcuguggccc cagcuaacga caucuacaac gagcgcgagc      480

ugcugaacag caugggcauc agccagccca ccgucguauu cgugagcaag aaagggcugc      540

aaaagauccu caacgugcaa aagaagcuac cgaucauaca aaagaucauc aucauggaua      600

gcaagaccga cuaccagggc uuccaaagca uguacaccuu cgugacuucc cauuugccac      660

ccggcuucaa cgaguacgac uucgugcccg agagcuucga ccgggacaaa accaucgccc      720

ugaucaugaa caguaguggc aguaccggau ugcccaaggg cguagcccua ccgcaccgca      780

ccgcuugugu ccgauucagu caugcccgcg accccaucuu cggcaaccag aucauccccg      840

acaccgcuau ccucagcgug gugccauuuc accacggcuu cggcauguuc accacgcugg      900

gcuacuugau cugcggcuuu cgggucgugc ucauguaccg cuucgaggag gagcuauucu      960

ugcgcagcuu gcaagacuau aagauucaau cugcccugcu ggugcccaca cuauuuagcu     1020

ucuucgcuaa gagcacucuc aucgacaagu acgaccuaag caacuugcac gagaucgcca     1080

gcggcggggc gccgcucagc aaggagguag gugaggccgu ggccaaacgc uuccaccuac     1140

caggcauccg ccagggcuac ggccugacag aaacaaccag cgccauucug aucacccccg     1200

aaggggacga caagccuggc gcaguaggca agguggugcc cuucuucgag gcuaaggugg     1260

uggacuugga caccgguaag acacugggug ugaaccagcg cggcgagcug ugcguccgug     1320

gccccaugau caugagcggc uacguuaaca accccgaggc uacaaacgcu cucaucgaca     1380

aggacggcug gcugcacagc ggcgacaucg ccuacuggga cgaggacgag cacuucuuca     1440

ucguggaccg gcugaagagc cugaucaaau acaagggcua ccagguagcc ccagccgaac     1500

uggagagcau ccugcugcaa caccccaaca ucuucgacgc cggggucgcc ggccugcccg     1560

acgacgaugc cggcgagcug cccgccgcag ucgucgugcu ggaacacggu aaaaccauga     1620

ccgagaagga gaucguggac uauguggcca gccagguuac aaccgccaag aagcugcgcg     1680

gugguguugu guucguggac gaggugccua aaggacugac cggcaaguug gacgcccgca     1740

agauccgcga gauucucauu aaggccaaga agggcggcaa gaucgccgug uaacgggugg     1800

caucccugug accccucccc agugccucuc cuggcccugg aaguugccac uccagugccc     1860

accagccuug uccuaauaaa auuaaguugc aucaaagcu                            1899


<210> 2
<211> 1485
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (1380)..(1380)
<223> May or may not be present

<220>
<221> modified_base
<222> (1482)..(1482)
<223> May or may not be present

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 2
ggacagaucg ccuggagacg ccauccacgc uguuuugacc uccauagaag acaccgggac       60

cgauccagcc uccgcggccg ggaacggugc auuggaacgc ggauuccccg ugccaagagu      120

gacucaccgu ccuugacacg augagcagca agggcagcgu ggugcuggcc uacagcggcg      180

gccuggacac cagcugcauc cugguguggc ugaaggagca gggcuacgac gugaucgccu      240

accuggccaa caucggccag aaggaggacu ucgaggaggc ccgcaagaag gcccugaagc      300

ugggcgccaa gaagguguuc aucgaggacg ugagccgcga guucguggag gaguucaucu      360

ggcccgccau ccagagcagc gcccuguacg aggaccgcua ccugcugggc accagccugg      420

cccgccccug caucgcccgc aagcaggugg agaucgccca gcgcgagggc gccaaguacg      480

ugagccacgg cgccaccggc aagggcaacg accaggugcg cuucgagcug agcugcuaca      540

gccuggcccc ccagaucaag gugaucgccc ccuggcgcau gcccgaguuc uacaaccgcu      600

ucaagggccg caacgaccug auggaguacg ccaagcagca cggcaucccc auccccguga      660

cccccaagaa ccccuggagc auggacgaga accugaugca caucagcuac gaggccggca      720

uccuggagaa ccccaagaac caggcccccc ccggccugua caccaagacc caggaccccg      780

ccaaggcccc caacaccccc gacauccugg agaucgaguu caagaagggc gugcccguga      840

aggugaccaa cgugaaggac ggcaccaccc accagaccag ccuggagcug uucauguacc      900

ugaacgaggu ggccggcaag cacggcgugg gccgcaucga caucguggag aaccgcuuca      960

ucggcaugaa gagccgcggc aucuacgaga cccccgccgg caccauccug uaccacgccc     1020

accuggacau cgaggccuuc accauggacc gcgaggugcg caagaucaag cagggccugg     1080

gccugaaguu cgccgagcug guguacaccg gcuucuggca cagccccgag ugcgaguucg     1140

ugcgccacug caucgccaag agccaggagc gcguggaggg caaggugcag gugagcgugc     1200

ugaagggcca gguguacauc cugggccgcg agagcccccu gagccuguac aacgaggagc     1260

uggugagcau gaacgugcag ggcgacuacg agcccaccga cgccaccggc uucaucaaca     1320

ucaacagccu gcgccugaag gaguaccacc gccugcagag caaggugacc gccaagugac     1380

ggguggcauc ccugugaccc cuccccagug ccucuccugg cccuggaagu ugccacucca     1440

gugcccacca gccuuguccu aauaaaauua aguugcauca aagcu                     1485


<210> 3
<211> 140
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
ggacagaucg ccuggagacg ccauccacgc uguuuugacc uccauagaag acaccgggac       60

cgauccagcc uccgcggccg ggaacggugc auuggaacgc ggauuccccg ugccaagagu      120

gacucaccgu ccuugacacg                                                  140


<210> 4
<211> 105
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
cggguggcau cccugugacc ccuccccagu gccucuccug gcccuggaag uugccacucc       60

agugcccacc agccuugucc uaauaaaauu aaguugcauc aagcu                      105


<210> 5
<211> 105
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
ggguggcauc ccugugaccc cuccccagug ccucuccugg cccuggaagu ugccacucca       60

gugcccacca gccuuguccu aauaaaauua aguugcauca aagcu                      105


<210> 6
<211> 500
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220> 
<221> misc_feature
<222> (1)..(500)
<223> This sequence may encompass 10-500 nucleotides

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 6
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      240

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      300

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      360

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      420

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      480

aaaaaaaaaa aaaaaaaaaa                                                  500


<210> 7
<211> 200
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220> 
<221> misc_feature
<222> (1)..(200)
<223> This sequence may encompass 10-200 nucleotides

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 7
cccccccccc cccccccccc cccccccccc cccccccccc cccccccccc cccccccccc       60

cccccccccc cccccccccc cccccccccc cccccccccc cccccccccc cccccccccc      120

cccccccccc cccccccccc cccccccccc cccccccccc cccccccccc cccccccccc      180

cccccccccc cccccccccc                                                  200


<210> 8
<211> 250
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      240

aaaaaaaaaa                                                             250


