                         SEQUENCE LISTING

<110>  Fountain Biopharma Inc.
 
<120>  METHOD OF PRODUCING RECOMBINANT PROTEINS WITH CONTROLLED GLYCAN 
       FORM

<130>  F0720.70001WO00

<150>  US 61/954,337
<151>  2014-03-17

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Gln Pro Pro Arg Arg Tyr Thr Pro Asp Trp Pro Ser 
            20                  25                  30          


Leu Asp Ser Arg Pro Leu Pro Ala Trp Phe Asp Glu Ala Lys Phe Gly 
        35                  40                  45              


Val Phe Ile His Trp Gly Val Phe Ser Val Pro Ala Trp Gly Ser Glu 
    50                  55                  60                  


Trp Phe Trp Trp His Trp Gln Gly Glu Gly Arg Pro Gln Tyr Gln Arg 
65                  70                  75                  80  


Phe Met Arg Asp Asn Tyr Pro Pro Gly Phe Ser Tyr Ala Asp Phe Gly 
                85                  90                  95      


Pro Gln Phe Thr Ala Arg Phe Phe His Pro Glu Glu Trp Ala Asp Leu 
            100                 105                 110         


Phe Gln Ala Ala Gly Ala Lys Tyr Val Val Leu Thr Thr Lys His His 
        115                 120                 125             


Glu Gly Phe Thr Asn Trp Pro Ser Pro Val Ser Trp Asn Trp Asn Ser 
    130                 135                 140                 


Lys Asp Val Gly Pro His Arg Asp Leu Val Gly Glu Leu Gly Thr Ala 
145                 150                 155                 160 


Leu Arg Lys Arg Asn Ile Arg Tyr Gly Leu Tyr His Ser Leu Leu Glu 
                165                 170                 175     


Trp Phe His Pro Leu Tyr Leu Leu Asp Lys Lys Asn Gly Phe Lys Thr 
            180                 185                 190         


Gln His Phe Val Ser Ala Lys Thr Met Pro Glu Leu Tyr Asp Leu Val 
        195                 200                 205             


Asn Ser Tyr Lys Pro Asp Leu Ile Trp Ser Asp Gly Glu Trp Glu Cys 
    210                 215                 220                 


Pro Asp Thr Tyr Trp Asn Ser Thr Asn Phe Leu Ser Trp Leu Tyr Asn 
225                 230                 235                 240 


Asp Ser Pro Val Lys Asp Glu Val Val Val Asn Asp Arg Trp Gly Gln 
                245                 250                 255     


Asn Cys Ser Cys His His Gly Gly Tyr Tyr Asn Cys Glu Asp Lys Phe 
            260                 265                 270         


Lys Pro Gln Ser Leu Pro Asp His Lys Trp Glu Met Cys Thr Ser Ile 
        275                 280                 285             


Asp Lys Phe Ser Trp Gly Tyr Arg Arg Asp Met Ala Leu Ser Asp Val 
    290                 295                 300                 


Thr Glu Glu Ser Glu Ile Ile Ser Glu Leu Val Gln Thr Val Ser Leu 
305                 310                 315                 320 


Gly Gly Asn Tyr Leu Leu Asn Ile Gly Pro Thr Lys Asp Gly Leu Ile 
                325                 330                 335     


Val Pro Ile Phe Gln Glu Arg Leu Leu Ala Val Gly Lys Trp Leu Ser 
            340                 345                 350         


Ile Asn Gly Glu Ala Ile Tyr Ala Ser Lys Pro Trp Arg Val Gln Trp 
        355                 360                 365             


Glu Lys Asn Thr Thr Ser Val Trp Tyr Thr Ser Lys Gly Ser Ala Val 
    370                 375                 380                 


Tyr Ala Ile Phe Leu His Trp Pro Glu Asn Gly Val Leu Asn Leu Glu 
385                 390                 395                 400 


Ser Pro Ile Thr Thr Ser Thr Thr Lys Ile Thr Met Leu Gly Ile Gln 
                405                 410                 415     


Gly Asp Leu Lys Trp Ser Thr Asp Pro Asp Lys Gly Leu Phe Ile Ser 
            420                 425                 430         


Leu Pro Gln Leu Pro Pro Ser Ala Val Pro Ala Glu Phe Ala Trp Thr 
        435                 440                 445             


Ile Lys Leu Thr Gly Val Lys His His His His His His 
    450                 455                 460     


<210>  2
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  2
atgagagtgc ctgctcagct gctgggactg ctgctgctgt ggctgcctgg tgctagatgc       60

cagccccctc ggagatacac ccctgactgg ccttccctgg actccagacc tctgcccgct      120

tggtttgacg aggccaagtt cggcgtgttc atccactggg gcgtgttctc cgtgcctgcc      180

tggggctctg agtggttctg gtggcattgg cagggcgagg gcagacctca gtaccagcgg      240

ttcatgcggg acaactaccc ccctggcttc tcctacgccg acttcggccc tcagttcacc      300

gcccggttct tccaccctga ggaatgggcc gatctgttcc aggccgctgg cgccaaatac      360

gtggtgctga ccaccaagca ccacgagggc ttcaccaact ggccctcccc cgtgtcctgg      420

aactggaact ctaaggacgt gggcccccac cgggatctcg tgggagaact gggaaccgcc      480

ctgcggaagc ggaacatcag atacggcctg taccactccc tgctggaatg gttccacccc      540

ctgtacctgc tggacaagaa gaacggcttc aagacccagc acttcgtgtc cgccaagacc      600

atgcccgagc tgtacgacct cgtgaactcc tacaagcccg acctgatttg gagcgacggc      660

gagtgggagt gccccgacac ctattggaac tccaccaact ttctgtcctg gctgtacaac      720

gactcccctg tgaaggacga ggtggtcgtg aacgacagat ggggccagaa ctgctcctgt      780

caccacggcg gctactacaa ctgcgaggac aagttcaagc cccagtccct gcccgaccac      840

aagtgggaga tgtgcacctc tatcgacaag ttctcctggg gctaccggcg ggacatggcc      900

ctgtctgatg tgaccgagga atccgagatc atctccgagc tggtgcagac cgtgtccctg      960

ggcggcaact acctgctgaa catcggccct accaaggacg gcctgatcgt gcccatcttc     1020

caggaacggc tgctggccgt gggcaagtgg ctgtctatca acggcgaggc catctacgcc     1080

tccaagcctt ggcgagtgca gtgggagaag aacaccacct ccgtgtggta cacctccaag     1140

ggctctgccg tgtacgccat cttcctgcac tggcccgaga acggcgtgct gaacctggaa     1200

tcccccatca ccacctctac caccaagatc accatgctgg gcatccaggg cgacctgaag     1260

tggtccaccg accctgacaa gggcctgttc atctccctgc cccagctgcc tccttccgct     1320

gtgcctgctg agttcgcctg gaccatcaag ctgaccggcg tgaagcacca ccaccatcac     1380

cattga                                                                1386


<210>  3
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys His Ser Ala Thr Arg Phe Asp Pro Thr Trp Glu Ser 
            20                  25                  30          


Leu Asp Ala Arg Gln Leu Pro Ala Trp Phe Asp Gln Ala Lys Phe Gly 
        35                  40                  45              


Ile Phe Ile His Trp Gly Val Phe Ser Val Pro Ser Phe Gly Ser Glu 
    50                  55                  60                  


Trp Phe Trp Trp Tyr Trp Gln Lys Glu Lys Ile Pro Lys Tyr Val Glu 
65                  70                  75                  80  


Phe Met Lys Asp Asn Tyr Pro Pro Ser Phe Lys Tyr Glu Asp Phe Gly 
                85                  90                  95      


Pro Leu Phe Thr Ala Lys Phe Phe Asn Ala Asn Gln Trp Ala Asp Ile 
            100                 105                 110         


Phe Gln Ala Ser Gly Ala Lys Tyr Ile Val Leu Thr Ser Lys His His 
        115                 120                 125             


Glu Gly Phe Thr Leu Trp Gly Ser Glu Tyr Ser Trp Asn Trp Asn Ala 
    130                 135                 140                 


Ile Asp Glu Gly Pro Lys Arg Asp Ile Val Lys Glu Leu Glu Val Ala 
145                 150                 155                 160 


Ile Arg Asn Arg Thr Asp Leu Arg Phe Gly Leu Tyr Tyr Ser Leu Phe 
                165                 170                 175     


Glu Trp Phe His Pro Leu Phe Leu Glu Asp Glu Ser Ser Ser Phe His 
            180                 185                 190         


Lys Arg Gln Phe Pro Val Ser Lys Thr Leu Pro Glu Leu Tyr Glu Leu 
        195                 200                 205             


Val Asn Asn Tyr Gln Pro Glu Val Leu Trp Ser Asp Gly Asp Gly Gly 
    210                 215                 220                 


Ala Pro Asp Gln Tyr Trp Asn Ser Thr Gly Phe Leu Ala Trp Leu Tyr 
225                 230                 235                 240 


Asn Glu Ser Pro Val Arg Gly Thr Val Val Thr Asn Asp Arg Trp Gly 
                245                 250                 255     


Ala Gly Ser Ile Cys Lys His Gly Gly Phe Tyr Thr Cys Ser Asp Arg 
            260                 265                 270         


Tyr Asn Pro Gly His Leu Leu Pro His Lys Trp Glu Asn Cys Met Thr 
        275                 280                 285             


Ile Asp Lys Leu Ser Trp Gly Tyr Arg Arg Glu Ala Gly Ile Ser Asp 
    290                 295                 300                 


Tyr Leu Thr Ile Glu Glu Leu Val Lys Gln Leu Val Glu Thr Val Ser 
305                 310                 315                 320 


Cys Gly Gly Asn Leu Leu Met Asn Ile Gly Pro Thr Leu Asp Gly Thr 
                325                 330                 335     


Ile Ser Val Val Phe Glu Glu Arg Leu Arg Gln Met Gly Ser Trp Leu 
            340                 345                 350         


Lys Val Asn Gly Glu Ala Ile Tyr Glu Thr His Thr Trp Arg Ser Gln 
        355                 360                 365             


Asn Asp Thr Val Thr Pro Asp Val Trp Tyr Thr Ser Lys Pro Lys Glu 
    370                 375                 380                 


Lys Leu Val Tyr Ala Ile Phe Leu Lys Trp Pro Thr Ser Gly Gln Leu 
385                 390                 395                 400 


Phe Leu Gly His Pro Lys Ala Ile Leu Gly Ala Thr Glu Val Lys Leu 
                405                 410                 415     


Leu Gly His Gly Gln Pro Leu Asn Trp Ile Ser Leu Glu Gln Asn Gly 
            420                 425                 430         


Ile Met Val Glu Leu Pro Gln Leu Thr Ile His Gln Met Pro Cys Lys 
        435                 440                 445             


Trp Gly Trp Ala Leu Ala Leu Thr Asn Val Ile His His His His His 
    450                 455                 460                 


His 
465 


<210>  4
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  4
atgagagtgc ctgctcagct gctgggactg ctgctgctgt ggctgcctgg cgctagatgc       60

cactccgcca ccagattcga ccccacctgg gagtctctgg acgccagaca gctgcccgct      120

tggtttgacc aggccaagtt cggcatcttc atccactggg gcgtgttctc cgtgcccagc      180

ttcggctctg agtggttctg gtggtactgg cagaaagaga agatccccaa atacgtggag      240

ttcatgaagg acaactaccc ccccagcttt aagtacgagg acttcggccc cctgttcacc      300

gccaagttct tcaacgccaa ccagtgggcc gacatcttcc aggcctctgg cgccaagtac      360

atcgtgctga cctccaagca ccacgagggc ttcaccctgt ggggctccga gtactcctgg      420

aactggaacg ccatcgacga gggccccaag cgggacatcg tgaaagaact ggaagtggcc      480

atccggaacc ggaccgacct gagattcggc ctgtactact ccctgttcga gtggttccac      540

cccctgtttc tggaagatga gtcctccagc ttccacaagc ggcagttccc cgtgtccaag      600

accctgcccg agctgtacga gctcgtgaac aactaccagc ccgaggtgct gtggagtgac      660

ggggatggtg gtgcccccga tcagtactgg aactctaccg gcttcctggc ctggctgtac      720

aacgagtctc ctgtgcgggg caccgtcgtg accaacgata gatggggcgc tggctccatc      780

tgcaagcacg gcggcttcta cacctgttcc gaccggtaca accccggcca tctgctgcct      840

cacaagtggg agaactgcat gaccatcgac aagctgtcct ggggctacag aagagaggcc      900

ggcatctccg actacctgac aatcgaggaa ctcgtgaagc agctggtgga aaccgtgtcc      960

tgcggcggca acctgctgat gaacatcggc cctaccctgg acggcaccat ctccgtggtg     1020

ttcgaggaac ggctgcggca gatgggctcc tggctgaaag tgaacggcga ggccatctac     1080

gagacacaca cctggcggtc ccagaacgac accgtgaccc ctgacgtgtg gtacaccagc     1140

aagcccaaag aaaagctggt gtatgccatc ttcctgaagt ggcctacctc cggccagctg     1200

ttcctgggcc accctaaggc tatcctgggc gccaccgaag tgaaactgct gggccatgga     1260

cagcccctga actggatctc cctggaacag aacggcatca tggtggaact gccccagctg     1320

accatccatc agatgccctg caaatggggc tgggccctgg ccctgaccaa cgtgatccac     1380

catcaccacc accactga                                                   1398


<210>  5
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Lys Ser Ser Arg Arg Tyr Asp Pro Thr Trp Glu Ser 
            20                  25                  30          


Leu Asp Arg Arg Pro Leu Pro Ser Trp Phe Asp Gln Ala Lys Phe Gly 
        35                  40                  45              


Ile Phe Ile His Trp Gly Val Phe Ser Val Pro Ser Phe Gly Ser Glu 
    50                  55                  60                  


Trp Phe Trp Trp Tyr Trp Gln Lys Glu Lys Arg Pro Lys Phe Val Asp 
65                  70                  75                  80  


Phe Met Asn Asn Asn Tyr Pro Pro Gly Phe Lys Tyr Glu Asp Phe Gly 
                85                  90                  95      


Val Leu Phe Thr Ala Lys Phe Phe Asn Ala Ser Gln Trp Ala Asp Ile 
            100                 105                 110         


Leu Gln Ala Ser Gly Ala Lys Tyr Leu Val Leu Thr Ser Lys His His 
        115                 120                 125             


Glu Gly Phe Thr Leu Trp Gly Ser Glu Tyr Ser Trp Asn Trp Asn Ala 
    130                 135                 140                 


Val Asp Glu Gly Pro Lys Arg Asp Ile Val Lys Glu Leu Lys Val Ala 
145                 150                 155                 160 


Ile Thr Lys Asn Thr Asp Leu Arg Phe Gly Leu Tyr Tyr Ser Leu Phe 
                165                 170                 175     


Glu Trp Phe His Pro Leu Phe Leu Glu Asp Lys Leu Ser Ser Phe Gln 
            180                 185                 190         


Lys Arg Gln Phe Pro Ile Ser Lys Met Leu Pro Glu Leu Tyr Glu Leu 
        195                 200                 205             


Val Asn Lys Tyr Gln Pro Asp Ile Leu Trp Thr Asp Gly Asp Gly Gly 
    210                 215                 220                 


Ala Pro Asp Arg Tyr Trp Asn Ser Thr Gly Phe Leu Ala Trp Leu Tyr 
225                 230                 235                 240 


Asn Glu Ser Pro Val Arg Asn Thr Val Val Thr Asn Asp Arg Trp Gly 
                245                 250                 255     


Ala Gly Ser Ile Cys Lys His Gly Gly Tyr Tyr Thr Cys Ser Asp Arg 
            260                 265                 270         


Tyr Asn Pro Gly His Leu Leu Pro His Lys Trp Glu Asn Cys Met Thr 
        275                 280                 285             


Ile Asp Gln Phe Ser Trp Gly Tyr Arg Arg Glu Ala Val Ile Ser Asp 
    290                 295                 300                 


Tyr Leu Thr Ile Glu Glu Leu Val Lys Gln Leu Val Glu Thr Val Ala 
305                 310                 315                 320 


Cys Gly Gly Asn Leu Leu Met Asn Ile Gly Pro Thr Leu Asp Gly Ile 
                325                 330                 335     


Ile Pro Val Ile Phe Glu Glu Arg Leu Arg Gln Met Gly Met Trp Leu 
            340                 345                 350         


Lys Val Asn Gly Glu Ala Ile Tyr Glu Thr Gln Pro Trp Arg Ser Gln 
        355                 360                 365             


Asn Asp Thr Ala Thr Pro Asp Val Trp Tyr Thr Tyr Lys Pro Glu Glu 
    370                 375                 380                 


Lys Ile Val Tyr Ala Ile Phe Leu Lys Trp Pro Val Ser Arg Glu Leu 
385                 390                 395                 400 


Phe Leu Glu Gln Pro Ile Gly Ser Leu Gly Glu Thr Glu Val Ala Leu 
                405                 410                 415     


Leu Gly Glu Gly Lys Pro Leu Thr Trp Thr Ser Leu Lys Pro Asn Gly 
            420                 425                 430         


Ile Ile Val Glu Leu Pro Gln Leu Thr Leu His Gln Met Pro Cys Lys 
        435                 440                 445             


Trp Gly Trp Thr Leu Ala Leu Thr Asn Val Thr His His His His His 
    450                 455                 460                 


His 
465 


<210>  6
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  6
atgagagtgc ctgctcagct gctgggactg ctgctgctgt ggctgcctgg cgctagatgc       60

aagtcctctc ggagatacga ccccacctgg gagtccctgg acagaaggcc tctgcccagt      120

tggttcgacc aggccaagtt cggcatcttc atccactggg gcgtgttctc cgtgcccagc      180

ttcggctctg agtggttctg gtggtactgg cagaaagaga agcggcccaa gttcgtggac      240

ttcatgaaca acaactaccc ccctggcttt aagtacgagg acttcggcgt gctgttcacc      300

gccaagttct tcaacgcctc ccagtgggcc gacatcctgc aggcttccgg cgctaagtac      360

ctggtgctga cctccaagca ccacgagggc tttaccctgt ggggctccga gtactcctgg      420

aactggaacg ccgtggacga gggccctaag cgggacatcg tgaaagaact gaaggtggcc      480

atcaccaaga acaccgacct gagattcggc ctgtactact ccctgttcga gtggttccac      540

cccctgtttc tggaagataa gctgtccagc ttccagaagc ggcagttccc catctccaag      600

atgctgcccg agctgtacga gctcgtgaac aagtaccagc ctgacatcct gtggaccgac      660

ggggatggtg gcgcccctga cagatactgg aactctaccg gcttcctggc ctggctgtac      720

aacgagtccc ctgtgcggaa caccgtcgtg accaacgaca gatggggcgc tggctccatc      780

tgcaagcacg gcggctacta cacctgttcc gaccggtaca accccggcca tctgctgcct      840

cacaagtggg agaactgcat gacaatcgac cagttctcct ggggctaccg gcgcgaggcc      900

gtgatctctg actacctgac catcgaggaa ctcgtgaagc agctggtgga aaccgtggcc      960

tgtggcggca acctgctgat gaacatcggc cctaccctgg acggcatcat ccccgtgatc     1020

ttcgaggaac ggctgcggca gatgggcatg tggctgaaag tgaacggcga ggccatctac     1080

gagacacagc cttggcggtc ccagaacgac accgccacac ctgacgtgtg gtacacctac     1140

aagcccgaag agaagatcgt gtacgccatc ttcctgaagt ggcccgtgtc cagagagctg     1200

tttctggaac agcccatcgg ctccctgggc gagacagaag tggctctgct gggcgagggc     1260

aagcctctga cctggacctc cctgaagccc aatggcatca tcgtggaact gccccagctg     1320

accctgcacc agatgccctg taaatggggc tggaccctgg ccctgaccaa cgtgacccac     1380

caccaccatc accactga                                                   1398


<210>  7
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys His Asn Val Ser Glu Gly Tyr Glu Lys Pro Ala Asp 
            20                  25                  30          


Pro Leu Val Val Gln Asn Leu Glu Gln Trp Gln Asp Leu Lys Phe Gly 
        35                  40                  45              


Leu Phe Met His Trp Gly Thr Tyr Ser Gln Trp Gly Ile Val Glu Ser 
    50                  55                  60                  


Trp Ser Leu Cys Pro Glu Asp Glu Ser Trp Thr Gln Arg Lys Pro Glu 
65                  70                  75                  80  


His Gly Lys Ser Tyr Asn Glu Tyr Val Lys Asn Tyr Glu Asn Leu Gln 
                85                  90                  95      


Thr Thr Phe Asn Pro Val Gln Phe Asn Pro Gln Lys Trp Ala Asp Ala 
            100                 105                 110         


Thr Lys Lys Ala Gly Met Lys Tyr Val Val Phe Thr Thr Lys His His 
        115                 120                 125             


Asp Gly Phe Ala Met Phe Asp Thr Lys Gln Ser Asp Tyr Lys Ile Thr 
    130                 135                 140                 


Ser Ser Lys Thr Pro Phe Ser Lys Asn Pro Lys Ala Asp Val Ala Lys 
145                 150                 155                 160 


Glu Ile Phe Asn Thr Phe Arg Asp Asn Gly Phe Arg Ile Gly Ala Tyr 
                165                 170                 175     


Phe Ser Lys Pro Asp Trp His Ser Asp Asp Tyr Trp Trp Ser Tyr Phe 
            180                 185                 190         


Pro Pro Lys Asp Arg Asn Val Asn Tyr Asp Pro Gln Lys Tyr Pro Ala 
        195                 200                 205             


Arg Trp Glu Asn Phe Lys Lys Phe Thr Phe Asn Gln Leu Asn Glu Ile 
    210                 215                 220                 


Thr Ser Asn Tyr Gly Lys Ile Asp Ile Leu Trp Leu Asp Gly Gly Trp 
225                 230                 235                 240 


Val Arg Pro Phe His Thr Ile Asp Pro Asn Ile Glu Trp Gln Arg Thr 
                245                 250                 255     


Ile Lys Val Glu Gln Asp Ile Asp Met Asp Lys Ile Gly Thr Met Ala 
            260                 265                 270         


Arg Lys Asn Gln Pro Gly Ile Ile Ile Val Asp Arg Thr Val Pro Gly 
        275                 280                 285             


Lys Trp Glu Asn Tyr Val Thr Pro Glu Gln Ala Val Pro Glu His Ala 
    290                 295                 300                 


Leu Ser Ile Pro Trp Glu Ser Cys Ile Thr Met Gly Asp Ser Phe Ser 
305                 310                 315                 320 


Tyr Val Pro Asn Asp Asn Tyr Lys Ser Ser Gln Lys Ile Ile Glu Thr 
                325                 330                 335     


Leu Ile Arg Ile Ile Ser Arg Gly Gly Asn Tyr Leu Met Asn Ile Ala 
            340                 345                 350         


Pro Gly Pro Asn Gly Asp Tyr Asp Ala Val Val Tyr Glu Arg Leu Lys 
        355                 360                 365             


Glu Ile Ser Gly Trp Met Asp Lys Asn Gln Ser Ala Val Phe Thr Thr 
    370                 375                 380                 


Arg Ala Leu Ala Pro Tyr His Glu Ser Asp Phe Tyr Tyr Thr Gln Ser 
385                 390                 395                 400 


Lys Asp Gly Lys Ile Val Asn Val Phe His Ile Ser Glu Lys Ser Asn 
                405                 410                 415     


Tyr Gln Ala Pro Ser Glu Leu Ser Phe Ser Ile Pro Glu Asn Ile Asn 
            420                 425                 430         


Pro Lys Thr Val Lys Val Leu Gly Ile Ser Ser Gln Ile Lys Trp Lys 
        435                 440                 445             


Lys Lys Gly Asn Lys Ile His Val Gln Leu Pro Glu Glu Arg Thr Lys 
    450                 455                 460                 


Leu Asn Tyr Ser Thr Val Ile Gln Ile Thr Gln His His His His His 
465                 470                 475                 480 


His 
    


<210>  8
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  8
atgagagtgc ctgctcagct gctgggactg ctgctgctgt ggctgcctgg cgctagatgc       60

cacaatgtgt ccgagggcta cgagaagccc gccgaccctc tggtggtgca gaacctggaa      120

cagtggcagg acctgaagtt cggcctgttc atgcactggg gcacctactc ccagtggggc      180

atcgtggaat cctggtccct gtgccctgag gacgagtctt ggacccagcg gaagcctgag      240

cacggcaagt cctacaacga gtacgtgaag aactacgaga acctgcagac caccttcaac      300

cccgtgcagt tcaaccccca gaagtgggcc gacgccacca agaaagccgg catgaaatac      360

gtggtgttca ccaccaagca ccacgacggc ttcgccatgt tcgacaccaa gcagtccgac      420

tacaagatca cctcctccaa gacccccttc agcaagaacc ccaaggccga cgtggccaaa      480

gagattttca acaccttccg ggacaacggc ttccggatcg gcgcctactt ctccaagcct      540

gactggcact ccgacgacta ctggtggtcc tacttcccac ccaaggaccg gaacgtgaac      600

tacgaccctc agaaataccc cgccagatgg gagaacttca agaagttcac cttcaatcag      660

ctgaacgaga tcaccagcaa ctacggcaag atcgacatcc tgtggctgga cggcggatgg      720

gtgcgaccct tccacaccat cgaccccaac atcgagtggc agcggaccat caaggtggaa      780

caggacatcg acatggacaa gatcggcacc atggcccgga agaaccagcc cggcatcatc      840

atcgtggacc ggaccgtgcc tggcaagtgg gagaattacg tgacccccga gcaggccgtg      900

cctgagcatg ccctgtctat cccttgggag tcctgtatca caatgggcga cagcttctcc      960

tacgtgccca acgacaacta caagtcctcc cagaagatca tcgagacact gatcaggatc     1020

atctccagag gcggcaacta cctgatgaat atcgcccctg gccccaacgg cgactacgac     1080

gctgtggtgt acgagcggct gaaagaaatc tccggctgga tggataagaa ccagtccgcc     1140

gtgtttacca cccgggctct ggccccttac cacgagtccg acttctacta cacccagtcc     1200

aaggacggaa agatcgtgaa cgtgttccac atctccgaga agtccaacta ccaggccccc     1260

tccgagctgt ccttcagcat ccccgagaac atcaacccca agaccgtgaa ggtgctgggc     1320

atctccagcc agatcaagtg gaagaagaag ggcaacaaga tccacgtgca gctgcccgag     1380

gaacggacca agctgaacta ctccaccgtg atccagatca cccagcacca ccaccatcac     1440

cactga                                                                1446


<210>  9
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  9

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Gln Gln Lys Tyr Gln Pro Thr Glu Ala Asn Leu Lys 
            20                  25                  30          


Ala Arg Ser Glu Phe Gln Asp Asn Lys Phe Gly Ile Phe Leu His Trp 
        35                  40                  45              


Gly Leu Tyr Ala Met Leu Ala Thr Gly Glu Trp Thr Met Thr Asn Asn 
    50                  55                  60                  


Asn Leu Asn Tyr Lys Glu Tyr Ala Lys Leu Ala Gly Gly Phe Tyr Pro 
65                  70                  75                  80  


Ser Lys Phe Asp Ala Asp Lys Trp Val Ala Ala Ile Lys Ala Ser Gly 
                85                  90                  95      


Ala Lys Tyr Ile Cys Phe Thr Thr Arg His His Glu Gly Phe Ser Met 
            100                 105                 110         


Phe Asp Thr Lys Tyr Ser Asp Tyr Asn Ile Val Lys Ala Thr Pro Phe 
        115                 120                 125             


Lys Arg Asp Val Val Lys Glu Leu Ala Asp Ala Cys Ala Lys His Gly 
    130                 135                 140                 


Ile Lys Leu His Phe Tyr Tyr Ser His Ile Asp Trp Tyr Arg Glu Asp 
145                 150                 155                 160 


Ala Pro Gln Gly Arg Thr Gly Arg Arg Thr Gly Arg Pro Asn Pro Lys 
                165                 170                 175     


Gly Asp Trp Lys Ser Tyr Tyr Gln Phe Met Asn Asn Gln Leu Thr Glu 
            180                 185                 190         


Leu Leu Thr Asn Tyr Gly Pro Ile Gly Ala Ile Trp Phe Asp Gly Trp 
        195                 200                 205             


Trp Asp Gln Asp Ile Asn Pro Asp Phe Asp Trp Glu Leu Pro Glu Gln 
    210                 215                 220                 


Tyr Ala Leu Ile His Arg Leu Gln Pro Ala Cys Leu Val Gly Asn Asn 
225                 230                 235                 240 


His His Gln Thr Pro Phe Ala Gly Glu Asp Ile Gln Ile Phe Glu Arg 
                245                 250                 255     


Asp Leu Pro Gly Glu Asn Thr Ala Gly Leu Ser Gly Gln Ser Val Ser 
            260                 265                 270         


His Leu Pro Leu Glu Thr Cys Glu Thr Met Asn Gly Met Trp Gly Tyr 
        275                 280                 285             


Lys Ile Thr Asp Gln Asn Tyr Lys Ser Thr Lys Thr Leu Ile His Tyr 
    290                 295                 300                 


Leu Val Lys Ala Ala Gly Lys Asp Ala Asn Leu Leu Met Asn Ile Gly 
305                 310                 315                 320 


Pro Gln Pro Asp Gly Glu Leu Pro Glu Val Ala Val Gln Arg Leu Lys 
                325                 330                 335     


Glu Val Gly Glu Trp Met Ser Lys Tyr Gly Glu Thr Ile Tyr Gly Thr 
            340                 345                 350         


Arg Gly Gly Leu Val Ala Pro His Asp Trp Gly Val Thr Thr Gln Lys 
        355                 360                 365             


Gly Asn Lys Leu Tyr Val His Ile Leu Asn Leu Gln Asp Lys Ala Leu 
    370                 375                 380                 


Phe Leu Pro Ile Val Asp Lys Lys Val Lys Lys Ala Val Val Phe Ala 
385                 390                 395                 400 


Asp Lys Thr Pro Val Arg Phe Thr Lys Asn Lys Glu Gly Ile Val Leu 
                405                 410                 415     


Glu Leu Ala Lys Val Pro Thr Asp Val Asp Tyr Val Val Glu Leu Thr 
            420                 425                 430         


Ile Asp His His His His His His 
        435                 440 


<210>  10
<211>  1323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  10
atgagagtgc ctgctcagct gctgggactg ctgctgctgt ggctgcctgg tgctagatgc       60

cagcagaagt accagcccac cgaggccaac ctgaaggcca gatccgagtt ccaggacaac      120

aagttcggca tcttcctgca ctggggcctg tacgccatgc tggctactgg cgagtggacc      180

atgaccaaca acaacctgaa ctacaaagag tacgctaagc tggctggcgg cttctacccc      240

tccaagttcg acgccgacaa atgggtggcc gccatcaagg cctctggcgc caagtacatc      300

tgcttcacca cccggcacca cgagggcttc tccatgttcg acaccaagta ctccgactac      360

aacatcgtga aggccacccc cttcaagcgg gacgtcgtga aagagctggc cgacgcctgc      420

gctaagcacg gcatcaagct gcacttctac tactcccaca tcgactggta cagagaggac      480

gccccccagg gcagaaccgg cagaagaaca ggcagaccca accccaaggg cgactggaag      540

tcctactacc agtttatgaa caaccagctg accgagctgc tgaccaacta cggccccatc      600

ggcgccattt ggttcgacgg gtggtgggac caggacatca accccgactt cgactgggag      660

ctgcccgagc agtacgccct gatccacaga ctgcagcccg cctgtctcgt gggcaacaac      720

caccaccaga ccccctttgc cggcgaggac atccagattt tcgagcggga tctgcccggc      780

gagaacaccg ctggactgtc tggccagtcc gtgtcccatc tgcccctgga aacctgcgag      840

acaatgaacg gcatgtgggg ctacaagatc accgaccaga actacaagtc caccaagaca      900

ctgatccact acctcgtgaa agccgctggc aaggacgcca acctgctgat gaacatcggc      960

ccccagcctg acggcgagct gcctgaagtg gctgtgcagc ggctgaaaga agtgggagag     1020

tggatgtcta agtacggcga gactatctac ggcaccagag gcggcctggt ggcccctcat     1080

gattggggcg tgaccaccca gaagggcaac aagctgtacg tgcacatcct gaacctgcag     1140

gacaaggccc tgttcctgcc catcgtggac aagaaagtga agaaagccgt ggtgttcgcc     1200

gacaagaccc ccgtgcggtt caccaagaac aaagagggca tcgtgctgga actggccaag     1260

gtgcccaccg acgtggacta cgtggtggaa ctgaccatcg accaccatca tcaccaccac     1320

tga                                                                   1323


<210>  11
<211>  920
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  11

Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Gly Ala Arg Cys Ala Gln His Asp Ser Leu Ile Arg Val Lys Ala Glu 
            20                  25                  30          


Asp Lys Val Val Gln Thr Ser Pro Ser Val Ser Ala Ile Asp Asp Leu 
        35                  40                  45              


His Tyr Leu Ser Glu Asn Ser Lys Lys Glu Phe Lys Glu Gly Leu Ser 
    50                  55                  60                  


Lys Ala Gly Glu Val Pro Glu Lys Leu Lys Asp Ile Leu Ser Lys Ala 
65                  70                  75                  80  


Gln Gln Ala Asp Lys Gln Ala Lys Val Leu Ala Glu Met Lys Val Pro 
                85                  90                  95      


Glu Lys Ile Ala Met Lys Pro Leu Lys Gly Pro Leu Tyr Gly Gly Tyr 
            100                 105                 110         


Phe Arg Thr Trp His Asp Lys Thr Ser Asp Pro Ala Glu Lys Asp Lys 
        115                 120                 125             


Val Asn Ser Met Gly Glu Leu Pro Lys Glu Val Asp Leu Ala Phe Val 
    130                 135                 140                 


Phe His Asp Trp Thr Lys Asp Tyr Ser Leu Phe Trp Gln Glu Leu Ala 
145                 150                 155                 160 


Thr Lys His Val Pro Thr Leu Asn Lys Gln Gly Thr Arg Val Ile Arg 
                165                 170                 175     


Thr Ile Pro Trp Arg Phe Leu Ala Gly Gly Asp His Ser Gly Ile Ala 
            180                 185                 190         


Glu Asp Thr Gln Lys Tyr Pro Asn Thr Pro Glu Gly Asn Lys Ala Leu 
        195                 200                 205             


Ala Lys Ala Ile Val Asp Glu Tyr Val Tyr Lys Tyr Asn Leu Asp Gly 
    210                 215                 220                 


Leu Asp Val Asp Ile Glu Arg Asp Ser Ile Pro Lys Val Asn Gly Lys 
225                 230                 235                 240 


Glu Ser Asn Glu Asn Ile Gln Arg Ser Ile Ala Val Phe Glu Glu Ile 
                245                 250                 255     


Gly Lys Leu Ile Gly Pro Lys Gly Ala Asp Lys Ser Arg Leu Phe Ile 
            260                 265                 270         


Met Asp Ser Thr Tyr Met Ala Asp Lys Asn Pro Leu Ile Glu Arg Gly 
        275                 280                 285             


Ala Pro Tyr Ile Asp Leu Leu Leu Val Gln Val Tyr Gly Ile Gln Gly 
    290                 295                 300                 


Glu Lys Gly Asp Trp Asp Pro Val Ala Arg Lys Pro Glu Lys Thr Met 
305                 310                 315                 320 


Glu Glu Arg Trp Glu Ser Tyr Ser Lys Tyr Ile Arg Pro Glu Gln Tyr 
                325                 330                 335     


Met Val Gly Phe Ser Phe Tyr Glu Glu Asn Ala Gly Ser Gly Asn Leu 
            340                 345                 350         


Trp Tyr Asp Ile Asn Glu Arg Lys Asp Asp His Asn Pro Leu Asn Ser 
        355                 360                 365             


Glu Ile Ala Gly Thr Arg Ala Glu Arg Tyr Ala Lys Trp Gln Pro Lys 
    370                 375                 380                 


Thr Gly Gly Val Lys Gly Gly Ile Phe Ser Tyr Ala Ile Asp Arg Asp 
385                 390                 395                 400 


Gly Val Ala His Gln Pro Lys Lys Val Ser Asp Asp Glu Lys Arg Thr 
                405                 410                 415     


Asn Lys Ala Ile Lys Asp Ile Thr Asp Gly Ile Val Lys Ser Asp Tyr 
            420                 425                 430         


Lys Val Ser Lys Ala Leu Lys Lys Val Met Glu Asn Asp Lys Ser Tyr 
        435                 440                 445             


Glu Leu Ile Asp Gln Lys Asp Phe Pro Asp Lys Ala Leu Arg Glu Ala 
    450                 455                 460                 


Val Ile Ala Gln Val Gly Ser Arg Arg Gly Asp Leu Glu Arg Phe Asn 
465                 470                 475                 480 


Gly Thr Leu Arg Leu Asp Asn Pro Asp Ile Lys Ser Leu Glu Gly Leu 
                485                 490                 495     


Asn Lys Leu Lys Lys Leu Ala Lys Leu Glu Leu Ile Gly Leu Ser Gln 
            500                 505                 510         


Ile Thr Lys Leu Asp Ser Ser Val Leu Pro Glu Asn Ile Lys Pro Thr 
        515                 520                 525             


Lys Asp Thr Leu Val Ser Val Leu Glu Thr Tyr Lys Asn Asp Asp Arg 
    530                 535                 540                 


Lys Glu Glu Ala Lys Ala Ile Pro Gln Val Ala Leu Thr Ile Ser Gly 
545                 550                 555                 560 


Leu Thr Gly Leu Lys Glu Leu Asn Leu Ala Gly Phe Asp Arg Asp Ser 
                565                 570                 575     


Leu Ala Gly Ile Asp Ala Ala Ser Leu Thr Ser Leu Glu Lys Val Asp 
            580                 585                 590         


Leu Ser Lys Asn Lys Leu Asp Leu Ala Ala Gly Thr Glu Asn Arg Gln 
        595                 600                 605             


Ile Phe Asp Val Met Leu Ser Thr Val Ser Asn Arg Val Gly Ser Asn 
    610                 615                 620                 


Glu Gln Thr Val Thr Phe Asp His Gln Lys Pro Thr Gly His Tyr Pro 
625                 630                 635                 640 


Asn Thr Tyr Gly Thr Thr Ser Leu Arg Leu Pro Val Gly Glu Gly Lys 
                645                 650                 655     


Ile Asp Leu Gln Ser Gln Leu Leu Phe Gly Thr Val Thr Asn Gln Gly 
            660                 665                 670         


Thr Leu Ile Asn Ser Glu Ala Asp Tyr Lys Ala Tyr Gln Glu Gln Leu 
        675                 680                 685             


Ile Ala Gly Arg Arg Phe Val Asp Pro Gly Tyr Ala Tyr Lys Asn Phe 
    690                 695                 700                 


Ala Val Thr Tyr Asp Ala Tyr Lys Val Arg Val Thr Asp Ser Thr Leu 
705                 710                 715                 720 


Gly Val Thr Asp Glu Lys Lys Leu Ser Thr Ser Lys Glu Glu Thr Tyr 
                725                 730                 735     


Lys Val Glu Phe Phe Ser Pro Thr Asn Gly Thr Lys Pro Val His Glu 
            740                 745                 750         


Ala Lys Val Val Val Gly Ala Glu Lys Thr Met Met Val Asn Leu Ala 
        755                 760                 765             


Ala Gly Ala Thr Val Ile Lys Ser Asp Ser His Glu Asn Ala Lys Lys 
    770                 775                 780                 


Val Phe Asp Gly Ala Ile Glu Tyr Asn Pro Leu Ser Phe Ser Ser Lys 
785                 790                 795                 800 


Thr Ser Ile Thr Phe Glu Phe Lys Glu Pro Gly Leu Val Lys Tyr Trp 
                805                 810                 815     


Arg Phe Phe Asn Asp Ile Thr Arg Lys Asp Asp Tyr Ile Lys Glu Ala 
            820                 825                 830         


Lys Leu Glu Ala Phe Val Gly His Leu Glu Asp Asp Ser Lys Val Lys 
        835                 840                 845             


Asp Ser Leu Glu Lys Ser Thr Glu Trp Val Thr Val Ser Asp Tyr Ser 
    850                 855                 860                 


Gly Glu Ala Gln Glu Phe Ser Gln Pro Leu Asp Asn Ile Ser Ala Lys 
865                 870                 875                 880 


Tyr Trp Arg Val Thr Val Asp Thr Lys Gly Gly Arg Tyr Ser Ser Pro 
                885                 890                 895     


Ser Leu Pro Glu Leu Gln Ile Leu Gly Tyr Arg Leu Pro Leu Thr His 
            900                 905                 910         


Asp Tyr Lys Asp Asp Asp Asp Lys 
        915                 920 


<210>  12
<211>  2763
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  12
atgagagtgc ctgctcagct gctgggcctg ctgctgctgt ggctgcctgg tgctagatgc       60

gcccagcacg actccctgat cagagtgaag gccgaggaca aggtggtgca gacctcccct      120

tccgtgtccg ccatcgacga cctgcactac ctgtccgaga actccaagaa agagttcaaa      180

gagggcctgt ccaaggccgg cgaggtgccc gaaaagctga aggacatcct gagcaaggct      240

cagcaggccg acaagcaggc caaggtgctg gccgagatga aggtgccaga gaagatcgcc      300

atgaagcccc tgaagggccc tctgtacggc ggctacttca gaacctggca cgacaagacc      360

tccgaccccg ccgagaagga caaagtgaac tccatgggcg agctgcccaa agaggtggac      420

ctggccttcg tgttccacga ctggaccaag gactactccc tgttctggca ggaactggcc      480

accaagcacg tgcccaccct gaacaagcag ggcaccagag tgatccggac aatcccctgg      540

cggtttctgg ctggcggcga ccactctgga atcgccgagg atacccagaa gtaccccaac      600

acccccgagg gcaacaaggc cctggctaag gccatcgtgg acgagtacgt gtacaagtac      660

aacctggacg gcctggacgt ggacatcgag cgggactcca tccctaaagt gaacggcaaa      720

gagtccaacg agaacatcca gcggtctatc gccgtgttcg aggaaatcgg caagctgatc      780

ggccccaagg gcgccgacaa gtcccggctg ttcatcatgg actccaccta catggccgat      840

aagaaccccc tgatcgagag aggcgcccct tacatcgatc tgctgctggt gcaggtgtac      900

ggcatccagg gcgagaaggg cgattgggac cctgtggccc ggaagcctga aaagaccatg      960

gaagagagat gggagtccta ctccaagtac atccggcccg agcagtatat ggtgggattc     1020

agcttctacg aggaaaacgc cggctccggc aacctgtggt acgacatcaa cgagcggaag     1080

gacgaccaca accctctgaa ctccgagatc gccggcaccc gggctgagag atacgctaag     1140

tggcagccca agaccggcgg agtgaagggc ggcatcttct cctacgccat cgatagggat     1200

ggcgtggccc accagcctaa gaaggtgtcc gacgacgaga agcggaccaa caaggctatc     1260

aaggacatca ccgacggcat cgtgaagtcc gactacaagg tgtccaaagc cctgaagaaa     1320

gtgatggaaa acgacaagag ctacgagctg atcgaccaga aggacttccc cgataaggcc     1380

ctgcgcgagg ccgtgattgc tcaagtgggc tccagacggg gcgacctgga aagattcaac     1440

ggcaccctgc ggctggacaa ccccgacatc aagtccctgg aaggcctgaa caaactgaag     1500

aagctggcca agctggaact gatcggactg tcccagatca caaagctgga ctcctccgtg     1560

ctgcctgaga acatcaagcc caccaaggac accctggtgt ccgtgctgga aacctacaag     1620

aacgacgacc ggaaagagga agccaaggcc atccctcagg tggccctgac catctctggc     1680

ctgaccggcc tgaaagagct gaatctggcc ggcttcgacc gggattccct ggctggaatc     1740

gatgccgcct ctctgacctc cctggaaaaa gtggacctgt ctaagaacaa gctggatctg     1800

gctgccggca ccgagaaccg gcagatcttc gacgtgatgc tgtccaccgt gtccaacaga     1860

gtgggcagca acgagcagac cgtgaccttc gaccaccaga agcccaccgg ccactaccct     1920

aacacctacg gcaccacctc cctgagactg cctgtgggcg agggcaagat cgacctgcag     1980

tcccagctgc tgttcggcac cgtgaccaac cagggcacac tgatcaactc cgaggccgat     2040

tacaaggcct accaggaaca gctgatcgct gggcggagat tcgtggaccc tggctacgct     2100

tacaagaact tcgccgtgac ctacgatgcc tacaaagtgc gcgtgaccga ctccaccctg     2160

ggcgtgacag acgaaaagaa gctgagcacc tccaaagaag agacatacaa ggtggaattc     2220

ttctccccca ccaatggcac caagcctgtg catgaggcta aggtggtcgt gggcgccgag     2280

aaaaccatga tggtcaacct ggccgctggc gccaccgtga tcaagtctga ctctcacgag     2340

aatgccaaaa aggtgttcga cggcgccatc gagtacaatc ctctgagctt ctccagcaag     2400

accagcatca ccttcgagtt taaagaaccc ggcctcgtga aatactggcg gttcttcaac     2460

gatatcaccc gcaaggacga ctacatcaaa gaggctaagc tggaagcctt cgtgggccat     2520

ctggaagatg actccaaagt gaaggactct ctggaaaagt ccaccgagtg ggtcaccgtg     2580

tctgactact ctggcgaggc ccaggaattc tcccagcccc tggacaacat ctccgccaag     2640

tattggagag tgaccgtgga caccaagggc ggacggtaca gctctcctag cctgcccgag     2700

ctgcagatcc tgggctacag actgcctctg acccacgact ataaggacga cgacgacaaa     2760

tga                                                                   2763


