                         SEQUENCE LISTING

<110>  Delenex Therapeutics AG
 
<120>  Binding members to TNF alpha

<130>  DD 40424

<150>  EP14001123.0
<151>  2014-03-26

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL sequence

<400>  1

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Thr Ser Asn 
                85                  90                  95      


Asn Ser Asp Gly Phe Trp Ala Phe Gly Gln Gly Thr Lys Leu Thr Val 
            100                 105                 110         


Leu Gly 
        


<210>  2
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Ile Asp Phe Ser Asn Ser 
            20                  25                  30          


Gly Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Gly Phe Gly Ile Arg Asn Tyr Ala Asn Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Pro Ile Tyr Ala Ser Ser Ser Gly Tyr Ala Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  3
<211>  11
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  3

Gln Ala Ser Gln Ser Ile Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  4
<211>  7
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  4

Trp Ala Ser Thr Leu Ala Ser 
1               5           


<210>  5
<211>  15
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  5

Gln Ser Tyr Tyr Tyr Thr Ser Asn Asn Ser Asp Gly Phe Trp Ala 
1               5                   10                  15  


<210>  6
<211>  9
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  6

Ile Asp Phe Ser Asn Ser Gly Ile Thr 
1               5                   


<210>  7
<211>  17
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  7

Tyr Ile Tyr Pro Gly Phe Gly Ile Arg Asn Tyr Ala Asn Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  13
<212>  PRT
<213>  Oryctolagus cuniculus

<400>  8

Asp Pro Ile Tyr Ala Ser Ser Ser Gly Tyr Ala Asp Ile 
1               5                   10              


<210>  9
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv1

<400>  9

Glu Ile Val Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ile Ile Thr Cys Gln Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Ser Tyr Tyr Tyr Thr Ser Asn 
                85                  90                  95      


Asn Ser Asp Gly Phe Trp Ala Phe Gly Gln Gly Thr Lys Leu Thr Val 
            100                 105                 110         


Leu Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
    130                 135                 140                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly 
145                 150                 155                 160 


Ile Asp Phe Ser Asn Ser Gly Ile Thr Trp Val Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Gly Leu Glu Trp Val Gly Tyr Ile Tyr Pro Gly Phe Gly Ile Arg 
            180                 185                 190         


Asn Tyr Ala Asn Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Thr 
        195                 200                 205             


Ser Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Ile Tyr Ala Ser Ser Ser 
225                 230                 235                 240 


Gly Tyr Ala Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 255     


<210>  10
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  10

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  11
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DLX105

<400>  11

Met Ala Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Leu Thr Cys Thr Ala Ser Gln Ser Val Ser 
            20                  25                  30          


Asn Asp Val Val Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Ala Phe Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Arg Gly Tyr Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Asn Ser 
                85                  90                  95      


Pro Arg Thr Phe Gly Gln Gly Thr Lys Leu Glu Val Lys Arg Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly 
        115                 120                 125             


Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
    130                 135                 140                 


Gly Ala Ser Val Lys Val Ser Cys Thr Ala Ser Gly Tyr Thr Phe Thr 
145                 150                 155                 160 


His Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Met Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Asp 
            180                 185                 190         


Lys Phe Lys Asp Arg Phe Thr Phe Ser Leu Glu Thr Ser Ala Ser Thr 
        195                 200                 205             


Val Tyr Met Glu Leu Thr Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Ala Arg Glu Arg Gly Asp Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


