                         SEQUENCE LISTING

<110>  Ruprecht-Karls-Universitt Heidelberg
 
<120>  Host dependency factors as targets for antiviral therapy

<130>  U30547WO

<150>  EP 14 161 494.1
<151>  2014-03-25

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  2265
<212>  DNA
<213>  Homo sapiens

<400>  1
acagccagag ggacgagcta gcccgacgat ggcccagggg acattgatcc gtgtgacccc       60

agagcagccc acccatgccg tgtgtgtgct gggcaccttg actcagcttg acatctgcag      120

ctctgcccct gaggactgca cgtccttcag catcaacgcc tccccagggg tggtcgtgga      180

tattgcccac ggccctccag ccaagaagaa atccacaggt tcctccacat ggcccctgga      240

ccctggggta gaggtgaccc tgacgatgaa agtggccagt ggtagcacag gcgaccagaa      300

ggttcagatt tcatactacg gacccaagac tccaccagtc aaagctctac tctacctcac      360

cggggtggaa atctccttgt gcgcagacat cacccgcacc ggcaaagtga agccaaccag      420

agctgtgaaa gatcagagga cctggacctg gggcccttgt ggacagggtg ccatcctgct      480

ggtgaactgt gacagagaca atctcgaatc ttctgccatg gactgcgagg atgatgaagt      540

gcttgacagc gaagacctgc aggacatgtc gctgatgacc ctgagcacga agacccccaa      600

ggacttcttc acaaaccata cactggtgct ccacgtggcc aggtctgaga tggacaaagt      660

gagggtgttt caggccacac ggggcaaact gtcctccaag tgcagcgtag tcttgggtcc      720

caagtggccc tctcactacc tgatggtccc cggtggaaag cacaacatgg acttctacgt      780

ggaggccctc gctttcccgg acaccgactt cccggggctc attaccctca ccatctccct      840

gctggacacg tccaacctgg agctccccga ggctgtggtg ttccaagaca gcgtggtctt      900

ccgcgtggcg ccctggatca tgacccccaa cacccagccc ccgcaggagg tgtacgcgtg      960

cagtattttt gaaaatgagg acttcctgaa gtcagtgact actctggcca tgaaagccaa     1020

gtgcaagctg accatctgcc ctgaggagga gaacatggat gaccagtgga tgcaggatga     1080

aatggagatc ggctacatcc aagccccaca caaaacgctg cccgtggtct tcgactctcc     1140

aaggaacaga ggcctgaagg agtttcccat caaacgcgtg atgggtccag attttggcta     1200

tgtaactcga gggccccaaa cagggggtat cagtggactg gactcctttg ggaacctgga     1260

agtgagcccc ccagtcacag tcaggggcaa ggaatacccg ctgggcagga ttctcttcgg     1320

ggacagctgt tatcccagca atgacagccg gcagatgcac caggccctgc aggacttcct     1380

cagtgcccag caggtgcagg cccctgtgaa gctctattct gactggctgt ccgtgggcca     1440

cgtggacgag ttcctgagct ttgtgccagc acccgacagg aagggcttcc ggctgctcct     1500

ggccagcccc aggtcctgct acaaactgtt ccaggagcag cagaatgagg gccacgggga     1560

ggccctgctg ttcgaaggga tcaagaaaaa aaaacagcag aaaataaaga acattctgtc     1620

aaacaagaca ttgagagaac ataattcatt tgtggagaga tgcatcgact ggaaccgcga     1680

gctgctgaag cgggagctgg gcctggccga gagtgacatc attgacatcc cgcagctctt     1740

caagctcaaa gagttctcta aggcggaagc ttttttcccc aacatggtga acatgctggt     1800

gctagggaag cacctgggca tccccaagcc cttcgggccc gtcatcaacg gccgctgctg     1860

cctggaggag aaggtgtgtt ccctgctgga gccactgggc ctccagtgca ccttcatcaa     1920

cgacttcttc acctaccaca tcaggcatgg ggaggtgcac tgcggcacca acgtgcgcag     1980

aaagcccttc tccttcaagt ggtggaacat ggtgccctga gcccatcttc cctggcgtcc     2040

tctccctcct ggccagatgt cgctgggtcc tctgcagtgt ggcaagcaag agctcttgtg     2100

aatattgtgg ctccctgggg gcggccagcc ctcccagcag tggcttgctt tcttctcctg     2160

tgatgtccca gtttcccact ctgaagatcc caacatggtc ctagcactgc acactcagtt     2220

ctgctctaag aagctgcaat aaagtttttt taagtcactt tgtac                     2265


<210>  2
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Gln Gly Thr Leu Ile Arg Val Thr Pro Glu Gln Pro Thr His 
1               5                   10                  15      


Ala Val Cys Val Leu Gly Thr Leu Thr Gln Leu Asp Ile Cys Ser Ser 
            20                  25                  30          


Ala Pro Glu Asp Cys Thr Ser Phe Ser Ile Asn Ala Ser Pro Gly Val 
        35                  40                  45              


Val Val Asp Ile Ala His Gly Pro Pro Ala Lys Lys Lys Ser Thr Gly 
    50                  55                  60                  


Ser Ser Thr Trp Pro Leu Asp Pro Gly Val Glu Val Thr Leu Thr Met 
65                  70                  75                  80  


Lys Val Ala Ser Gly Ser Thr Gly Asp Gln Lys Val Gln Ile Ser Tyr 
                85                  90                  95      


Tyr Gly Pro Lys Thr Pro Pro Val Lys Ala Leu Leu Tyr Leu Thr Gly 
            100                 105                 110         


Val Glu Ile Ser Leu Cys Ala Asp Ile Thr Arg Thr Gly Lys Val Lys 
        115                 120                 125             


Pro Thr Arg Ala Val Lys Asp Gln Arg Thr Trp Thr Trp Gly Pro Cys 
    130                 135                 140                 


Gly Gln Gly Ala Ile Leu Leu Val Asn Cys Asp Arg Asp Asn Leu Glu 
145                 150                 155                 160 


Ser Ser Ala Met Asp Cys Glu Asp Asp Glu Val Leu Asp Ser Glu Asp 
                165                 170                 175     


Leu Gln Asp Met Ser Leu Met Thr Leu Ser Thr Lys Thr Pro Lys Asp 
            180                 185                 190         


Phe Phe Thr Asn His Thr Leu Val Leu His Val Ala Arg Ser Glu Met 
        195                 200                 205             


Asp Lys Val Arg Val Phe Gln Ala Thr Arg Gly Lys Leu Ser Ser Lys 
    210                 215                 220                 


Cys Ser Val Val Leu Gly Pro Lys Trp Pro Ser His Tyr Leu Met Val 
225                 230                 235                 240 


Pro Gly Gly Lys His Asn Met Asp Phe Tyr Val Glu Ala Leu Ala Phe 
                245                 250                 255     


Pro Asp Thr Asp Phe Pro Gly Leu Ile Thr Leu Thr Ile Ser Leu Leu 
            260                 265                 270         


Asp Thr Ser Asn Leu Glu Leu Pro Glu Ala Val Val Phe Gln Asp Ser 
        275                 280                 285             


Val Val Phe Arg Val Ala Pro Trp Ile Met Thr Pro Asn Thr Gln Pro 
    290                 295                 300                 


Pro Gln Glu Val Tyr Ala Cys Ser Ile Phe Glu Asn Glu Asp Phe Leu 
305                 310                 315                 320 


Lys Ser Val Thr Thr Leu Ala Met Lys Ala Lys Cys Lys Leu Thr Ile 
                325                 330                 335     


Cys Pro Glu Glu Glu Asn Met Asp Asp Gln Trp Met Gln Asp Glu Met 
            340                 345                 350         


Glu Ile Gly Tyr Ile Gln Ala Pro His Lys Thr Leu Pro Val Val Phe 
        355                 360                 365             


Asp Ser Pro Arg Asn Arg Gly Leu Lys Glu Phe Pro Ile Lys Arg Val 
    370                 375                 380                 


Met Gly Pro Asp Phe Gly Tyr Val Thr Arg Gly Pro Gln Thr Gly Gly 
385                 390                 395                 400 


Ile Ser Gly Leu Asp Ser Phe Gly Asn Leu Glu Val Ser Pro Pro Val 
                405                 410                 415     


Thr Val Arg Gly Lys Glu Tyr Pro Leu Gly Arg Ile Leu Phe Gly Asp 
            420                 425                 430         


Ser Cys Tyr Pro Ser Asn Asp Ser Arg Gln Met His Gln Ala Leu Gln 
        435                 440                 445             


Asp Phe Leu Ser Ala Gln Gln Val Gln Ala Pro Val Lys Leu Tyr Ser 
    450                 455                 460                 


Asp Trp Leu Ser Val Gly His Val Asp Glu Phe Leu Ser Phe Val Pro 
465                 470                 475                 480 


Ala Pro Asp Arg Lys Gly Phe Arg Leu Leu Leu Ala Ser Pro Arg Ser 
                485                 490                 495     


Cys Tyr Lys Leu Phe Gln Glu Gln Gln Asn Glu Gly His Gly Glu Ala 
            500                 505                 510         


Leu Leu Phe Glu Gly Ile Lys Lys Lys Lys Gln Gln Lys Ile Lys Asn 
        515                 520                 525             


Ile Leu Ser Asn Lys Thr Leu Arg Glu His Asn Ser Phe Val Glu Arg 
    530                 535                 540                 


Cys Ile Asp Trp Asn Arg Glu Leu Leu Lys Arg Glu Leu Gly Leu Ala 
545                 550                 555                 560 


Glu Ser Asp Ile Ile Asp Ile Pro Gln Leu Phe Lys Leu Lys Glu Phe 
                565                 570                 575     


Ser Lys Ala Glu Ala Phe Phe Pro Asn Met Val Asn Met Leu Val Leu 
            580                 585                 590         


Gly Lys His Leu Gly Ile Pro Lys Pro Phe Gly Pro Val Ile Asn Gly 
        595                 600                 605             


Arg Cys Cys Leu Glu Glu Lys Val Cys Ser Leu Leu Glu Pro Leu Gly 
    610                 615                 620                 


Leu Gln Cys Thr Phe Ile Asn Asp Phe Phe Thr Tyr His Ile Arg His 
625                 630                 635                 640 


Gly Glu Val His Cys Gly Thr Asn Val Arg Arg Lys Pro Phe Ser Phe 
                645                 650                 655     


Lys Trp Trp Asn Met Val Pro 
            660             


<210>  3
<211>  3749
<212>  DNA
<213>  Homo sapiens

<400>  3
gcggagcgtg tgacgctgcg gccgccgcgg acctggggat taatgggaaa agttttggca       60

ggagcgggag aattctgcgg agcctgcggg acggcggcgg tggcgccgta ggcagccggg      120

acagtgttgt acagtgtttt gggcatgcac gtgatactca cacagtggct tctgctcacc      180

aacagatgaa gacagatgca ccaacgaggc tgatgggaac caccctgtag aggtccatct      240

gcgttcagac ccagacgatg ccagagctat gactgggcct gcaggtgtgg cgccgagggg      300

agatcagcca tggagcagcc acaggaggaa gcccctgagg tccgggaaga ggaggagaaa      360

gaggaagtgg cagaggcaga aggagcccca gagctcaatg ggggaccaca gcatgcactt      420

ccttccagca gctacacaga cctctcccgg agctcctcgc caccctcact gctggaccaa      480

ctgcagatgg gctgtgacgg ggcctcatgc ggcagcctca acatggagtg ccgggtgtgc      540

ggggacaagg catcgggctt ccactacggt gttcatgcat gtgaggggtg caagggcttc      600

ttccgtcgta cgatccgcat gaagctggag tacgagaagt gtgagcgcag ctgcaagatt      660

cagaagaaga accgcaacaa gtgccagtac tgccgcttcc agaagtgcct ggcactgggc      720

atgtcacaca acgctatccg ttttggtcgg atgccggagg ctgagaagag gaagctggtg      780

gcagggctga ctgcaaacga ggggagccag tacaacccac aggtggccga cctgaaggcc      840

ttctccaagc acatctacaa tgcctacctg aaaaacttca acatgaccaa aaagaaggcc      900

cgcagcatcc tcaccggcaa agccagccac acggcgccct ttgtgatcca cgacatcgag      960

acattgtggc aggcagagaa ggggctggtg tggaagcagt tggtgaatgg cctgcctccc     1020

tacaaggaga tcagcgtgca cgtcttctac cgctgccagt gcaccacagt ggagaccgtg     1080

cgggagctca ctgagttcgc caagagcatc cccagcttca gcagcctctt cctcaacgac     1140

caggttaccc ttctcaagta tggcgtgcac gaggccatct tcgccatgct ggcctctatc     1200

gtcaacaagg acgggctgct ggtagccaac ggcagtggct ttgtcacccg tgagttcctg     1260

cgcagcctcc gcaaaccctt cagtgatatc attgagccta agtttgaatt tgctgtcaag     1320

ttcaacgccc tggaacttga tgacagtgac ctggccctat tcattgcggc catcattctg     1380

tgtggagacc ggccaggcct catgaacgtt ccacgggtgg aggctatcca ggacaccatc     1440

ctgcgtgccc tcgaattcca cctgcaggcc aaccaccctg atgcccagta cctcttcccc     1500

aagctgctgc agaagatggc tgacctgcgg caactggtca ccgagcacgc ccagatgatg     1560

cagcggatca agaagaccga aaccgagacc tcgctgcacc ctctgctcca ggagatctac     1620

aaggacatgt actaacggcg gcacccaggc ctccctgcag actccaatgg ggccagcact     1680

ggaggggccc acccacatga cttttccatt gaccagccct tgagcacccg gcctggagca     1740

gcagagtccc acgatcgccc tcagacacat gacacccacg gcctctggct ccctgtgccc     1800

tctctcccgc ttcctccagc cagctctctt cctgtctttg ttgtctccct ctttctcagt     1860

tcctctttct tttctaattc ctgttgctct gtttcttcct ttctgtaggt ttctctcttc     1920

ccttctccct tgccctccct ttctctctcc accccccacg tctgtcctcc tttcttattc     1980

tgtgagatgt tttgtattat ttcaccagca gcatagaaca ggacctctgc ttttgcacac     2040

cttttcccca ggagcagaag agagtggggc ctgccctctg ccccatcatt gcacctgcag     2100

gcttaggtcc tcacttctgt ctcctgtctt cagagcaaaa gacttgagcc atccaaagaa     2160

acactaagct ctctgggcct gggttccagg gaaggctaag catggcctgg actgactgca     2220

gccccctata gtcatggggt ccctgctgca aaggacagtg ggcaggaggc cccaggctga     2280

gagccagatg cctccccaag actgtcattg cccctccgat gctgaggcca cccactgacc     2340

caactgatcc tgctccagca gcacacctca gccccactga cacccagtgt ccttccatct     2400

tcacactggt ttgccaggcc aatgttgctg atggccccct gcactggccg ctggacggca     2460

ctctcccagc ttggaagtag gcagggttcc ctccaggtgg gcccccacct cactgaagag     2520

gagcaagtct caagagaagg aggggggatt ggtggttgga ggaagcagca cacccaattc     2580

tgcccctagg actcggggtc tgagtcctgg ggtcaggcca gggagagctc ggggcaggcc     2640

ttccgccagc actcccactg cccccctgcc cagtagcagc cgcccacatt gtgtcagcat     2700

ccagggccag ggcctggcct cacatccccc tgctcctttc tctagctggc tccacgggag     2760

ttcaggcccc actccccctg aagctgcccc tccagcacac acacataagc actgaaatca     2820

ctttacctgc aggctccatg cacctccctt ccctccctga ggcaggtgag aacccagaga     2880

gaggggcctg caggtgagca ggcagggctg ggccaggtct ccggggaggc aggggtcctg     2940

caggtcctgg tgggtcagcc cagcacctgc tcccagtggg agcttcccgg gataaactga     3000

gcctgttcat tctgatgtcc atttgtccca atagctctac tgccctcccc ttccccttta     3060

ctcagcccag ctggccacct agaagtctcc ctgcacagcc tctagtgtcc ggggaccttg     3120

tgggaccagt cccacaccgc tggtccctgc cctcccctgc tcccaggttg aggtgcgctc     3180

acctcagagc agggccaaag cacagctggg catgccatgt ctgagcggcg cagagccctc     3240

caggcctgca ggggcaaggg gctggctgga gtctcagagc acagaggtag gagaactggg     3300

gttcaagccc aggcttcctg ggtcctgcct ggtcctccct cccaaggagc cattctgtgt     3360

gtgactctgg gtggaagtgc ccagcccctg cccctacggg cgctgcagcc tcccttccat     3420

gccccaggat cactctctgc tggcaggatt cttcccgctc cccacctacc cagctgatgg     3480

gggttggggt gcttcctttc aggccaaggc tatgaaggga cagctgctgg gacccacctc     3540

cccctccccg gccacatgcc gcgtccctgc cccgacccgg gtctggtgct gaggatacag     3600

ctcttctcag tgtctgaaca atctccaaaa ttgaaatgta tatttttgct aggagcccca     3660

gcttcctgtg tttttaatat aaatagtgta cacagactga cgaaacttta aataaatggg     3720

aattaaatat ttaagagctg actggaaaa                                       3749


<210>  4
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Gln Pro Gln Glu Glu Ala Pro Glu Val Arg Glu Glu Glu Glu 
1               5                   10                  15      


Lys Glu Glu Val Ala Glu Ala Glu Gly Ala Pro Glu Leu Asn Gly Gly 
            20                  25                  30          


Pro Gln His Ala Leu Pro Ser Ser Ser Tyr Thr Asp Leu Ser Arg Ser 
        35                  40                  45              


Ser Ser Pro Pro Ser Leu Leu Asp Gln Leu Gln Met Gly Cys Asp Gly 
    50                  55                  60                  


Ala Ser Cys Gly Ser Leu Asn Met Glu Cys Arg Val Cys Gly Asp Lys 
65                  70                  75                  80  


Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly 
                85                  90                  95      


Phe Phe Arg Arg Thr Ile Arg Met Lys Leu Glu Tyr Glu Lys Cys Glu 
            100                 105                 110         


Arg Ser Cys Lys Ile Gln Lys Lys Asn Arg Asn Lys Cys Gln Tyr Cys 
        115                 120                 125             


Arg Phe Gln Lys Cys Leu Ala Leu Gly Met Ser His Asn Ala Ile Arg 
    130                 135                 140                 


Phe Gly Arg Met Pro Glu Ala Glu Lys Arg Lys Leu Val Ala Gly Leu 
145                 150                 155                 160 


Thr Ala Asn Glu Gly Ser Gln Tyr Asn Pro Gln Val Ala Asp Leu Lys 
                165                 170                 175     


Ala Phe Ser Lys His Ile Tyr Asn Ala Tyr Leu Lys Asn Phe Asn Met 
            180                 185                 190         


Thr Lys Lys Lys Ala Arg Ser Ile Leu Thr Gly Lys Ala Ser His Thr 
        195                 200                 205             


Ala Pro Phe Val Ile His Asp Ile Glu Thr Leu Trp Gln Ala Glu Lys 
    210                 215                 220                 


Gly Leu Val Trp Lys Gln Leu Val Asn Gly Leu Pro Pro Tyr Lys Glu 
225                 230                 235                 240 


Ile Ser Val His Val Phe Tyr Arg Cys Gln Cys Thr Thr Val Glu Thr 
                245                 250                 255     


Val Arg Glu Leu Thr Glu Phe Ala Lys Ser Ile Pro Ser Phe Ser Ser 
            260                 265                 270         


Leu Phe Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu 
        275                 280                 285             


Ala Ile Phe Ala Met Leu Ala Ser Ile Val Asn Lys Asp Gly Leu Leu 
    290                 295                 300                 


Val Ala Asn Gly Ser Gly Phe Val Thr Arg Glu Phe Leu Arg Ser Leu 
305                 310                 315                 320 


Arg Lys Pro Phe Ser Asp Ile Ile Glu Pro Lys Phe Glu Phe Ala Val 
                325                 330                 335     


Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Leu Phe Ile 
            340                 345                 350         


Ala Ala Ile Ile Leu Cys Gly Asp Arg Pro Gly Leu Met Asn Val Pro 
        355                 360                 365             


Arg Val Glu Ala Ile Gln Asp Thr Ile Leu Arg Ala Leu Glu Phe His 
    370                 375                 380                 


Leu Gln Ala Asn His Pro Asp Ala Gln Tyr Leu Phe Pro Lys Leu Leu 
385                 390                 395                 400 


Gln Lys Met Ala Asp Leu Arg Gln Leu Val Thr Glu His Ala Gln Met 
                405                 410                 415     


Met Gln Arg Ile Lys Lys Thr Glu Thr Glu Thr Ser Leu His Pro Leu 
            420                 425                 430         


Leu Gln Glu Ile Tyr Lys Asp Met Tyr 
        435                 440     


<210>  5
<211>  2028
<212>  DNA
<213>  Homo sapiens

<400>  5
gcggagcgtg tgacgctgcg gccgccgcgg acctggggat taatgggaaa agttttggca       60

ggagcgggag aattctgcgg agcctgcggg acggcggcgg tggcgccgta ggcagccggg      120

acagtgttgt acagtgtttt gggcatgcac gtgatactca cacagtggct tctgctcacc      180

aacagatgaa gacagatgca ccaacgaggc tgatgggaac caccctgtag aggtccatct      240

gcgttcagac ccagacgatg ccagagctat gactgggcct gcaggtgtgg cgccgagggg      300

agatcagcca tggagcagcc acaggaggaa gcccctgagg tccgggaaga ggaggagaaa      360

gaggaagtgg cagaggcaga aggagcccca gagctcaatg ggggaccaca gcatgcactt      420

ccttccagca gctacacaga cctctcccgg agctcctcgc caccctcact gctggaccaa      480

ctgcagatgg gctgtgacgg ggcctcatgc ggcagcctca acatggagtg ccgggtgtgc      540

ggggacaagg catcgggctt ccactacggt gttcatgcat gtgaggggtg caagggcttc      600

ttccgtcgta cgatccgcat gaagctggag tacgagaagt gtgagcgcag ctgcaagatt      660

cagaagaaga accgcaacaa gtgccagtac tgccgcttcc agaagtgcct ggcactgggc      720

atgtcacaca acgctatccg ttttggtcgg atgccggagg ctgagaagag gaagctggtg      780

gcagggctga ctgcaaacga ggggagccag tacaacccac aggtggccga cctgaaggcc      840

ttctccaagc acatctacaa tgcctacctg aaaaacttca acatgaccaa aaagaaggcc      900

cgcagcatcc tcaccggcaa agccagccac acggcgccct ttgtgatcca cgacatcgag      960

acattgtggc aggcagagaa ggggctggtg tggaagcagt tggtgaatgg cctgcctccc     1020

tacaaggaga tcagcgtgca cgtcttctac cgctgccagt gcaccacagt ggagaccgtg     1080

cgggagctca ctgagttcgc caagagcatc cccagcttca gcagcctctt cctcaacgac     1140

caggttaccc ttctcaagta tggcgtgcac gaggccatct tcgccatgct ggcctctatc     1200

gtcaacaagg acgggctgct ggtagccaac ggcagtggct ttgtcacccg tgagttcctg     1260

cgcagcctcc gcaaaccctt cagtgatatc attgagccta agtttgaatt tgctgtcaag     1320

ttcaacgccc tggaacttga tgacagtgac ctggccctat tcattgcggc catcattctg     1380

tgtggaggtg agtgagagtg gggcaggtgg gctggcctgg cacacccagt cgtcctgggg     1440

gttggccctc actgcagggc actgtgcctg agctctgaca gtgtggggaa gtgtccctgt     1500

gatcttggca gtggaacatg caaggcactg actgagcatg caggatcagc tccatctcat     1560

tatgtacgta gatagaggtg gagacaggaa aaagactaag ccagacgtgg tggctcacac     1620

ctgtaatccc agcactttgg caggccgagg cgggtggatc acttgaggtc aggagttcga     1680

aaccagcctg gccaacatgg tgaaaccccg tctctactaa aaatacaaaa aattagccag     1740

atgtggtggc acgcgcctgt aatcccagct acttgggagg ctgagccagg agaatcgctt     1800

gaacccgaga ggtggaggtt gcagtgagcc aaaatcccac cactgcactc cagcctgggt     1860

gacagagtga gaccctgtct caaaaaaaag gaaaaggact aacaggcagt atgctgtcat     1920

gttaatgtgg ggtggaaaaa ttgtctgcat tttttctgca tttttaaaat tccaacacaa     1980

taaatacaat aataactatg ctaaaaaaaa aaaaaaaaaa aaaaaaaa                  2028


<210>  6
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Gln Pro Gln Glu Glu Ala Pro Glu Val Arg Glu Glu Glu Glu 
1               5                   10                  15      


Lys Glu Glu Val Ala Glu Ala Glu Gly Ala Pro Glu Leu Asn Gly Gly 
            20                  25                  30          


Pro Gln His Ala Leu Pro Ser Ser Ser Tyr Thr Asp Leu Ser Arg Ser 
        35                  40                  45              


Ser Ser Pro Pro Ser Leu Leu Asp Gln Leu Gln Met Gly Cys Asp Gly 
    50                  55                  60                  


Ala Ser Cys Gly Ser Leu Asn Met Glu Cys Arg Val Cys Gly Asp Lys 
65                  70                  75                  80  


Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly 
                85                  90                  95      


Phe Phe Arg Arg Thr Ile Arg Met Lys Leu Glu Tyr Glu Lys Cys Glu 
            100                 105                 110         


Arg Ser Cys Lys Ile Gln Lys Lys Asn Arg Asn Lys Cys Gln Tyr Cys 
        115                 120                 125             


Arg Phe Gln Lys Cys Leu Ala Leu Gly Met Ser His Asn Ala Ile Arg 
    130                 135                 140                 


Phe Gly Arg Met Pro Glu Ala Glu Lys Arg Lys Leu Val Ala Gly Leu 
145                 150                 155                 160 


Thr Ala Asn Glu Gly Ser Gln Tyr Asn Pro Gln Val Ala Asp Leu Lys 
                165                 170                 175     


Ala Phe Ser Lys His Ile Tyr Asn Ala Tyr Leu Lys Asn Phe Asn Met 
            180                 185                 190         


Thr Lys Lys Lys Ala Arg Ser Ile Leu Thr Gly Lys Ala Ser His Thr 
        195                 200                 205             


Ala Pro Phe Val Ile His Asp Ile Glu Thr Leu Trp Gln Ala Glu Lys 
    210                 215                 220                 


Gly Leu Val Trp Lys Gln Leu Val Asn Gly Leu Pro Pro Tyr Lys Glu 
225                 230                 235                 240 


Ile Ser Val His Val Phe Tyr Arg Cys Gln Cys Thr Thr Val Glu Thr 
                245                 250                 255     


Val Arg Glu Leu Thr Glu Phe Ala Lys Ser Ile Pro Ser Phe Ser Ser 
            260                 265                 270         


Leu Phe Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu 
        275                 280                 285             


Ala Ile Phe Ala Met Leu Ala Ser Ile Val Asn Lys Asp Gly Leu Leu 
    290                 295                 300                 


Val Ala Asn Gly Ser Gly Phe Val Thr Arg Glu Phe Leu Arg Ser Leu 
305                 310                 315                 320 


Arg Lys Pro Phe Ser Asp Ile Ile Glu Pro Lys Phe Glu Phe Ala Val 
                325                 330                 335     


Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Leu Phe Ile 
            340                 345                 350         


Ala Ala Ile Ile Leu Cys Gly Gly Glu 
        355                 360     


<210>  7
<211>  3518
<212>  DNA
<213>  Homo sapiens

<400>  7
gcggagcgtg tgacgctgcg gccgccgcgg acctggggat taatgggaaa agttttggca       60

ggagcgggag aattctgcgg agcctgcggg acggcggcgg tggcgccgta ggcagccggg      120

acagtgttgt acagtgtttt gggcatgcac gtgatactca cacagtggct tctgctcacc      180

aacagatgaa gacagatgca ccaacgagac ctctcccgga gctcctcgcc accctcactg      240

ctggaccaac tgcagatggg ctgtgacggg gcctcatgcg gcagcctcaa catggagtgc      300

cgggtgtgcg gggacaaggc atcgggcttc cactacggtg ttcatgcatg tgaggggtgc      360

aagggcttct tccgtcgtac gatccgcatg aagctggagt acgagaagtg tgagcgcagc      420

tgcaagattc agaagaagaa ccgcaacaag tgccagtact gccgcttcca gaagtgcctg      480

gcactgggca tgtcacacaa cgctatccgt tttggtcgga tgccggaggc tgagaagagg      540

aagctggtgg cagggctgac tgcaaacgag gggagccagt acaacccaca ggtggccgac      600

ctgaaggcct tctccaagca catctacaat gcctacctga aaaacttcaa catgaccaaa      660

aagaaggccc gcagcatcct caccggcaaa gccagccaca cggcgccctt tgtgatccac      720

gacatcgaga cattgtggca ggcagagaag gggctggtgt ggaagcagtt ggtgaatggc      780

ctgcctccct acaaggagat cagcgtgcac gtcttctacc gctgccagtg caccacagtg      840

gagaccgtgc gggagctcac tgagttcgcc aagagcatcc ccagcttcag cagcctcttc      900

ctcaacgacc aggttaccct tctcaagtat ggcgtgcacg aggccatctt cgccatgctg      960

gcctctatcg tcaacaagga cgggctgctg gtagccaacg gcagtggctt tgtcacccgt     1020

gagttcctgc gcagcctccg caaacccttc agtgatatca ttgagcctaa gtttgaattt     1080

gctgtcaagt tcaacgccct ggaacttgat gacagtgacc tggccctatt cattgcggcc     1140

atcattctgt gtggagaccg gccaggcctc atgaacgttc cacgggtgga ggctatccag     1200

gacaccatcc tgcgtgccct cgaattccac ctgcaggcca accaccctga tgcccagtac     1260

ctcttcccca agctgctgca gaagatggct gacctgcggc aactggtcac cgagcacgcc     1320

cagatgatgc agcggatcaa gaagaccgaa accgagacct cgctgcaccc tctgctccag     1380

gagatctaca aggacatgta ctaacggcgg cacccaggcc tccctgcaga ctccaatggg     1440

gccagcactg gaggggccca cccacatgac ttttccattg accagccctt gagcacccgg     1500

cctggagcag cagagtccca cgatcgccct cagacacatg acacccacgg cctctggctc     1560

cctgtgccct ctctcccgct tcctccagcc agctctcttc ctgtctttgt tgtctccctc     1620

tttctcagtt cctctttctt ttctaattcc tgttgctctg tttcttcctt tctgtaggtt     1680

tctctcttcc cttctccctt gccctccctt tctctctcca ccccccacgt ctgtcctcct     1740

ttcttattct gtgagatgtt ttgtattatt tcaccagcag catagaacag gacctctgct     1800

tttgcacacc ttttccccag gagcagaaga gagtggggcc tgccctctgc cccatcattg     1860

cacctgcagg cttaggtcct cacttctgtc tcctgtcttc agagcaaaag acttgagcca     1920

tccaaagaaa cactaagctc tctgggcctg ggttccaggg aaggctaagc atggcctgga     1980

ctgactgcag ccccctatag tcatggggtc cctgctgcaa aggacagtgg gcaggaggcc     2040

ccaggctgag agccagatgc ctccccaaga ctgtcattgc ccctccgatg ctgaggccac     2100

ccactgaccc aactgatcct gctccagcag cacacctcag ccccactgac acccagtgtc     2160

cttccatctt cacactggtt tgccaggcca atgttgctga tggccccctg cactggccgc     2220

tggacggcac tctcccagct tggaagtagg cagggttccc tccaggtggg cccccacctc     2280

actgaagagg agcaagtctc aagagaagga ggggggattg gtggttggag gaagcagcac     2340

acccaattct gcccctagga ctcggggtct gagtcctggg gtcaggccag ggagagctcg     2400

gggcaggcct tccgccagca ctcccactgc ccccctgccc agtagcagcc gcccacattg     2460

tgtcagcatc cagggccagg gcctggcctc acatccccct gctcctttct ctagctggct     2520

ccacgggagt tcaggcccca ctccccctga agctgcccct ccagcacaca cacataagca     2580

ctgaaatcac tttacctgca ggctccatgc acctcccttc cctccctgag gcaggtgaga     2640

acccagagag aggggcctgc aggtgagcag gcagggctgg gccaggtctc cggggaggca     2700

ggggtcctgc aggtcctggt gggtcagccc agcacctgct cccagtggga gcttcccggg     2760

ataaactgag cctgttcatt ctgatgtcca tttgtcccaa tagctctact gccctcccct     2820

tcccctttac tcagcccagc tggccaccta gaagtctccc tgcacagcct ctagtgtccg     2880

gggaccttgt gggaccagtc ccacaccgct ggtccctgcc ctcccctgct cccaggttga     2940

ggtgcgctca cctcagagca gggccaaagc acagctgggc atgccatgtc tgagcggcgc     3000

agagccctcc aggcctgcag gggcaagggg ctggctggag tctcagagca cagaggtagg     3060

agaactgggg ttcaagccca ggcttcctgg gtcctgcctg gtcctccctc ccaaggagcc     3120

attctgtgtg tgactctggg tggaagtgcc cagcccctgc ccctacgggc gctgcagcct     3180

cccttccatg ccccaggatc actctctgct ggcaggattc ttcccgctcc ccacctaccc     3240

agctgatggg ggttggggtg cttcctttca ggccaaggct atgaagggac agctgctggg     3300

acccacctcc ccctccccgg ccacatgccg cgtccctgcc ccgacccggg tctggtgctg     3360

aggatacagc tcttctcagt gtctgaacaa tctccaaaat tgaaatgtat atttttgcta     3420

ggagccccag cttcctgtgt ttttaatata aatagtgtac acagactgac gaaactttaa     3480

ataaatggga attaaatatt taagagctga ctggaaaa                             3518


<210>  8
<211>  402
<212>  PRT
<213>  Homo sapiens

<400>  8

Met His Gln Arg Asp Leu Ser Arg Ser Ser Ser Pro Pro Ser Leu Leu 
1               5                   10                  15      


Asp Gln Leu Gln Met Gly Cys Asp Gly Ala Ser Cys Gly Ser Leu Asn 
            20                  25                  30          


Met Glu Cys Arg Val Cys Gly Asp Lys Ala Ser Gly Phe His Tyr Gly 
        35                  40                  45              


Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Thr Ile Arg 
    50                  55                  60                  


Met Lys Leu Glu Tyr Glu Lys Cys Glu Arg Ser Cys Lys Ile Gln Lys 
65                  70                  75                  80  


Lys Asn Arg Asn Lys Cys Gln Tyr Cys Arg Phe Gln Lys Cys Leu Ala 
                85                  90                  95      


Leu Gly Met Ser His Asn Ala Ile Arg Phe Gly Arg Met Pro Glu Ala 
            100                 105                 110         


Glu Lys Arg Lys Leu Val Ala Gly Leu Thr Ala Asn Glu Gly Ser Gln 
        115                 120                 125             


Tyr Asn Pro Gln Val Ala Asp Leu Lys Ala Phe Ser Lys His Ile Tyr 
    130                 135                 140                 


Asn Ala Tyr Leu Lys Asn Phe Asn Met Thr Lys Lys Lys Ala Arg Ser 
145                 150                 155                 160 


Ile Leu Thr Gly Lys Ala Ser His Thr Ala Pro Phe Val Ile His Asp 
                165                 170                 175     


Ile Glu Thr Leu Trp Gln Ala Glu Lys Gly Leu Val Trp Lys Gln Leu 
            180                 185                 190         


Val Asn Gly Leu Pro Pro Tyr Lys Glu Ile Ser Val His Val Phe Tyr 
        195                 200                 205             


Arg Cys Gln Cys Thr Thr Val Glu Thr Val Arg Glu Leu Thr Glu Phe 
    210                 215                 220                 


Ala Lys Ser Ile Pro Ser Phe Ser Ser Leu Phe Leu Asn Asp Gln Val 
225                 230                 235                 240 


Thr Leu Leu Lys Tyr Gly Val His Glu Ala Ile Phe Ala Met Leu Ala 
                245                 250                 255     


Ser Ile Val Asn Lys Asp Gly Leu Leu Val Ala Asn Gly Ser Gly Phe 
            260                 265                 270         


Val Thr Arg Glu Phe Leu Arg Ser Leu Arg Lys Pro Phe Ser Asp Ile 
        275                 280                 285             


Ile Glu Pro Lys Phe Glu Phe Ala Val Lys Phe Asn Ala Leu Glu Leu 
    290                 295                 300                 


Asp Asp Ser Asp Leu Ala Leu Phe Ile Ala Ala Ile Ile Leu Cys Gly 
305                 310                 315                 320 


Asp Arg Pro Gly Leu Met Asn Val Pro Arg Val Glu Ala Ile Gln Asp 
                325                 330                 335     


Thr Ile Leu Arg Ala Leu Glu Phe His Leu Gln Ala Asn His Pro Asp 
            340                 345                 350         


Ala Gln Tyr Leu Phe Pro Lys Leu Leu Gln Lys Met Ala Asp Leu Arg 
        355                 360                 365             


Gln Leu Val Thr Glu His Ala Gln Met Met Gln Arg Ile Lys Lys Thr 
    370                 375                 380                 


Glu Thr Glu Thr Ser Leu His Pro Leu Leu Gln Glu Ile Tyr Lys Asp 
385                 390                 395                 400 


Met Tyr 
        


<210>  9
<211>  3455
<212>  DNA
<213>  Homo sapiens

<400>  9
gcggagcgtg tgacgctgcg gccgccgcgg acctggggat taatgggaaa agttttggca       60

ggagcgggag aattctgcgg agcctgcggg acggcggcgg tggcgccgta ggcagccggg      120

acagtgttgt acagtgtttt gggcatgcac gtgatactca cacagtggct tctgctcacc      180

aacagatgaa gacagatgca ccaacgaggc tgatgggaac caccctgtag aggtccatct      240

gcgttcagac ccagacgatg ccagagctat gactgggcct gcaggtgtgg cgccgagggg      300

agatcagcca tggagcagcc acaggaggaa gcccctgagg tccgggaaga ggaggagaaa      360

gaggaagtgg cagaggcaga aggagcccca gagctcaatg ggggaccaca gcatgcactt      420

ccttccagca gctacacagc tatccgtttt ggtcggatgc cggaggctga gaagaggaag      480

ctggtggcag ggctgactgc aaacgagggg agccagtaca acccacaggt ggccgacctg      540

aaggccttct ccaagcacat ctacaatgcc tacctgaaaa acttcaacat gaccaaaaag      600

aaggcccgca gcatcctcac cggcaaagcc agccacacgg cgccctttgt gatccacgac      660

atcgagacat tgtggcaggc agagaagggg ctggtgtgga agcagttggt gaatggcctg      720

cctccctaca aggagatcag cgtgcacgtc ttctaccgct gccagtgcac cacagtggag      780

accgtgcggg agctcactga gttcgccaag agcatcccca gcttcagcag cctcttcctc      840

aacgaccagg ttacccttct caagtatggc gtgcacgagg ccatcttcgc catgctggcc      900

tctatcgtca acaaggacgg gctgctggta gccaacggca gtggctttgt cacccgtgag      960

ttcctgcgca gcctccgcaa acccttcagt gatatcattg agcctaagtt tgaatttgct     1020

gtcaagttca acgccctgga acttgatgac agtgacctgg ccctattcat tgcggccatc     1080

attctgtgtg gagaccggcc aggcctcatg aacgttccac gggtggaggc tatccaggac     1140

accatcctgc gtgccctcga attccacctg caggccaacc accctgatgc ccagtacctc     1200

ttccccaagc tgctgcagaa gatggctgac ctgcggcaac tggtcaccga gcacgcccag     1260

atgatgcagc ggatcaagaa gaccgaaacc gagacctcgc tgcaccctct gctccaggag     1320

atctacaagg acatgtacta acggcggcac ccaggcctcc ctgcagactc caatggggcc     1380

agcactggag gggcccaccc acatgacttt tccattgacc agcccttgag cacccggcct     1440

ggagcagcag agtcccacga tcgccctcag acacatgaca cccacggcct ctggctccct     1500

gtgccctctc tcccgcttcc tccagccagc tctcttcctg tctttgttgt ctccctcttt     1560

ctcagttcct ctttcttttc taattcctgt tgctctgttt cttcctttct gtaggtttct     1620

ctcttccctt ctcccttgcc ctccctttct ctctccaccc cccacgtctg tcctcctttc     1680

ttattctgtg agatgttttg tattatttca ccagcagcat agaacaggac ctctgctttt     1740

gcacaccttt tccccaggag cagaagagag tggggcctgc cctctgcccc atcattgcac     1800

ctgcaggctt aggtcctcac ttctgtctcc tgtcttcaga gcaaaagact tgagccatcc     1860

aaagaaacac taagctctct gggcctgggt tccagggaag gctaagcatg gcctggactg     1920

actgcagccc cctatagtca tggggtccct gctgcaaagg acagtgggca ggaggcccca     1980

ggctgagagc cagatgcctc cccaagactg tcattgcccc tccgatgctg aggccaccca     2040

ctgacccaac tgatcctgct ccagcagcac acctcagccc cactgacacc cagtgtcctt     2100

ccatcttcac actggtttgc caggccaatg ttgctgatgg ccccctgcac tggccgctgg     2160

acggcactct cccagcttgg aagtaggcag ggttccctcc aggtgggccc ccacctcact     2220

gaagaggagc aagtctcaag agaaggaggg gggattggtg gttggaggaa gcagcacacc     2280

caattctgcc cctaggactc ggggtctgag tcctggggtc aggccaggga gagctcgggg     2340

caggccttcc gccagcactc ccactgcccc cctgcccagt agcagccgcc cacattgtgt     2400

cagcatccag ggccagggcc tggcctcaca tccccctgct cctttctcta gctggctcca     2460

cgggagttca ggccccactc cccctgaagc tgcccctcca gcacacacac ataagcactg     2520

aaatcacttt acctgcaggc tccatgcacc tcccttccct ccctgaggca ggtgagaacc     2580

cagagagagg ggcctgcagg tgagcaggca gggctgggcc aggtctccgg ggaggcaggg     2640

gtcctgcagg tcctggtggg tcagcccagc acctgctccc agtgggagct tcccgggata     2700

aactgagcct gttcattctg atgtccattt gtcccaatag ctctactgcc ctccccttcc     2760

cctttactca gcccagctgg ccacctagaa gtctccctgc acagcctcta gtgtccgggg     2820

accttgtggg accagtccca caccgctggt ccctgccctc ccctgctccc aggttgaggt     2880

gcgctcacct cagagcaggg ccaaagcaca gctgggcatg ccatgtctga gcggcgcaga     2940

gccctccagg cctgcagggg caaggggctg gctggagtct cagagcacag aggtaggaga     3000

actggggttc aagcccaggc ttcctgggtc ctgcctggtc ctccctccca aggagccatt     3060

ctgtgtgtga ctctgggtgg aagtgcccag cccctgcccc tacgggcgct gcagcctccc     3120

ttccatgccc caggatcact ctctgctggc aggattcttc ccgctcccca cctacccagc     3180

tgatgggggt tggggtgctt cctttcaggc caaggctatg aagggacagc tgctgggacc     3240

cacctccccc tccccggcca catgccgcgt ccctgccccg acccgggtct ggtgctgagg     3300

atacagctct tctcagtgtc tgaacaatct ccaaaattga aatgtatatt tttgctagga     3360

gccccagctt cctgtgtttt taatataaat agtgtacaca gactgacgaa actttaaata     3420

aatgggaatt aaatatttaa gagctgactg gaaaa                                3455


<210>  10
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Gln Pro Gln Glu Glu Ala Pro Glu Val Arg Glu Glu Glu Glu 
1               5                   10                  15      


Lys Glu Glu Val Ala Glu Ala Glu Gly Ala Pro Glu Leu Asn Gly Gly 
            20                  25                  30          


Pro Gln His Ala Leu Pro Ser Ser Ser Tyr Thr Ala Ile Arg Phe Gly 
        35                  40                  45              


Arg Met Pro Glu Ala Glu Lys Arg Lys Leu Val Ala Gly Leu Thr Ala 
    50                  55                  60                  


Asn Glu Gly Ser Gln Tyr Asn Pro Gln Val Ala Asp Leu Lys Ala Phe 
65                  70                  75                  80  


Ser Lys His Ile Tyr Asn Ala Tyr Leu Lys Asn Phe Asn Met Thr Lys 
                85                  90                  95      


Lys Lys Ala Arg Ser Ile Leu Thr Gly Lys Ala Ser His Thr Ala Pro 
            100                 105                 110         


Phe Val Ile His Asp Ile Glu Thr Leu Trp Gln Ala Glu Lys Gly Leu 
        115                 120                 125             


Val Trp Lys Gln Leu Val Asn Gly Leu Pro Pro Tyr Lys Glu Ile Ser 
    130                 135                 140                 


Val His Val Phe Tyr Arg Cys Gln Cys Thr Thr Val Glu Thr Val Arg 
145                 150                 155                 160 


Glu Leu Thr Glu Phe Ala Lys Ser Ile Pro Ser Phe Ser Ser Leu Phe 
                165                 170                 175     


Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu Ala Ile 
            180                 185                 190         


Phe Ala Met Leu Ala Ser Ile Val Asn Lys Asp Gly Leu Leu Val Ala 
        195                 200                 205             


Asn Gly Ser Gly Phe Val Thr Arg Glu Phe Leu Arg Ser Leu Arg Lys 
    210                 215                 220                 


Pro Phe Ser Asp Ile Ile Glu Pro Lys Phe Glu Phe Ala Val Lys Phe 
225                 230                 235                 240 


Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Leu Phe Ile Ala Ala 
                245                 250                 255     


Ile Ile Leu Cys Gly Asp Arg Pro Gly Leu Met Asn Val Pro Arg Val 
            260                 265                 270         


Glu Ala Ile Gln Asp Thr Ile Leu Arg Ala Leu Glu Phe His Leu Gln 
        275                 280                 285             


Ala Asn His Pro Asp Ala Gln Tyr Leu Phe Pro Lys Leu Leu Gln Lys 
    290                 295                 300                 


Met Ala Asp Leu Arg Gln Leu Val Thr Glu His Ala Gln Met Met Gln 
305                 310                 315                 320 


Arg Ile Lys Lys Thr Glu Thr Glu Thr Ser Leu His Pro Leu Leu Gln 
                325                 330                 335     


Glu Ile Tyr Lys Asp Met Tyr 
            340             


<210>  11
<211>  2197
<212>  DNA
<213>  Homo sapiens

<400>  11
attgtgacca gaggggtttg tgtggctgaa gaggcaggag gaacagtgta tccacagcgt       60

gggaccatgc caggcacaaa acggtttcaa catgtcattg agaccccgga gcctggcaag      120

tgggagttgt ctgggtacga ggcagctgtg ccaatcacgg agaagtcaaa cccactgacc      180

caggatctag acaaagcaga tgctgagaac attgttcgac tgctagggca atgtgatgct      240

gagatcttcc aggaggaggg gcaagccctg tccacatacc agagactcta cagcgaatcc      300

attctgacca ccatggtaca ggtggctggg aaagttcagg aagtgctgaa ggagccagat      360

ggggggctgg ttgtgctgag tggagggggc acctctggcc ggatggcatt cctcatgtcg      420

gtgtccttta atcagctgat gaaaggtctg ggacagaaac ctctttacac ctacctcatt      480

gcaggtggtg acaggtctgt ggtggcctct agggagggga cagaagatag tgccttgcac      540

gggattgagg aactgaagaa ggtggctgcc gggaagaaga gagtgattgt cattggcatt      600

tctgtgggac tctctgctcc ctttgtggca ggccagatgg actgctgcat gaacaacaca      660

gctgtcttct tgccagtcct ggttggcttc aatccagtga gcatggccag aaatgacccc      720

attgaagact ggagttcaac attccgacaa gtagcagagc ggatgcagaa aatgcaggag      780

aaacagaaag cttttgtgct caatcctgcc atcgggcccg agggtctcag cggctcctcc      840

cggatgaaag gtggaagtgc caccaagatt ctgctggaaa ccctgttatt agcagcccat      900

aagactgtgg accagggcat tgcagcatct caaagatgcc tcctggaaat cttgcggaca      960

tttgagcgag ctcatcaggt gacctacagc caaagcccca agattgccac cctgatgaag     1020

agtgtcagca ccagtctgga gaagaaaggc cacgtgtacc tggttggctg gcagaccctg     1080

ggcatcattg ccatcatgga tggagtagag tgcatccaca cctttggtgc tgatttccga     1140

gatgtccgtg gctttctcat tggtgatcac agtgacatgt ttaaccagaa ggctgagctc     1200

accaaccagg gtccccagtt caccttctcc caggaggact tcctgacttc catccttccc     1260

tctctcacgg aaatcgatac tgtggtcttc attttcaccc tggatgacaa cctcacggag     1320

gtgcagacta tagtggagca ggtgaaagag aagaccaacc acatccaggc cctggcacac     1380

agcaccgtgg gtcagacctt gctgatccct ctgaagaagc tctttccctc catcatcagc     1440

atcacatggc cactgctttt ctttgaatat gaagggaact tcatccagaa gttccagcgt     1500

gagctaagca ccaaatgggt gctgaataca gtgagtacag gtgctcatgt gcttcttggt     1560

aagatcctac aaaaccacat gttggacctt cggattagca actccaagct cttctggcgg     1620

gcgctggcca tgctgcagcg gttctctgga cagtccaagg ctcgatgcat cgagagcctc     1680

ctccgagcga tccactttcc ccagccactg tcagatgata ttcgggctgc tcccatctcc     1740

tgccatgtcc aggttgcaca tgagaaggaa caggtgatac ccatcgcctt gctgagcctc     1800

ctattccggt gctcgatcac tgaggctcag gcacacctgg ctgcagctcc ttctgtctgt     1860

gaggctgtca ggagtgctct tgctgggcca ggtcagaagc gcactgcgga ccccctcgag     1920

atcctagagc ctgacgttca gtgaacccat gtttctgggt gggtgaaagg ggcccaaccc     1980

tgcccacttc agcccagccc gcccaagggg acttgtgcca gcagaacatg tgggaggaag     2040

aagccccgtt tccagggcat ccgcagccca gggtagggag aaatattctc tccactttgg     2100

gggagagttc ttgctctcga cctagtggtt tctactctca ccgacttatt ctgatttcag     2160

aaataaaatg aaatgtctta ttttggaaaa aaaaaaa                              2197


<210>  12
<211>  625
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Pro Gly Thr Lys Arg Phe Gln His Val Ile Glu Thr Pro Glu Pro 
1               5                   10                  15      


Gly Lys Trp Glu Leu Ser Gly Tyr Glu Ala Ala Val Pro Ile Thr Glu 
            20                  25                  30          


Lys Ser Asn Pro Leu Thr Gln Asp Leu Asp Lys Ala Asp Ala Glu Asn 
        35                  40                  45              


Ile Val Arg Leu Leu Gly Gln Cys Asp Ala Glu Ile Phe Gln Glu Glu 
    50                  55                  60                  


Gly Gln Ala Leu Ser Thr Tyr Gln Arg Leu Tyr Ser Glu Ser Ile Leu 
65                  70                  75                  80  


Thr Thr Met Val Gln Val Ala Gly Lys Val Gln Glu Val Leu Lys Glu 
                85                  90                  95      


Pro Asp Gly Gly Leu Val Val Leu Ser Gly Gly Gly Thr Ser Gly Arg 
            100                 105                 110         


Met Ala Phe Leu Met Ser Val Ser Phe Asn Gln Leu Met Lys Gly Leu 
        115                 120                 125             


Gly Gln Lys Pro Leu Tyr Thr Tyr Leu Ile Ala Gly Gly Asp Arg Ser 
    130                 135                 140                 


Val Val Ala Ser Arg Glu Gly Thr Glu Asp Ser Ala Leu His Gly Ile 
145                 150                 155                 160 


Glu Glu Leu Lys Lys Val Ala Ala Gly Lys Lys Arg Val Ile Val Ile 
                165                 170                 175     


Gly Ile Ser Val Gly Leu Ser Ala Pro Phe Val Ala Gly Gln Met Asp 
            180                 185                 190         


Cys Cys Met Asn Asn Thr Ala Val Phe Leu Pro Val Leu Val Gly Phe 
        195                 200                 205             


Asn Pro Val Ser Met Ala Arg Asn Asp Pro Ile Glu Asp Trp Ser Ser 
    210                 215                 220                 


Thr Phe Arg Gln Val Ala Glu Arg Met Gln Lys Met Gln Glu Lys Gln 
225                 230                 235                 240 


Lys Ala Phe Val Leu Asn Pro Ala Ile Gly Pro Glu Gly Leu Ser Gly 
                245                 250                 255     


Ser Ser Arg Met Lys Gly Gly Ser Ala Thr Lys Ile Leu Leu Glu Thr 
            260                 265                 270         


Leu Leu Leu Ala Ala His Lys Thr Val Asp Gln Gly Ile Ala Ala Ser 
        275                 280                 285             


Gln Arg Cys Leu Leu Glu Ile Leu Arg Thr Phe Glu Arg Ala His Gln 
    290                 295                 300                 


Val Thr Tyr Ser Gln Ser Pro Lys Ile Ala Thr Leu Met Lys Ser Val 
305                 310                 315                 320 


Ser Thr Ser Leu Glu Lys Lys Gly His Val Tyr Leu Val Gly Trp Gln 
                325                 330                 335     


Thr Leu Gly Ile Ile Ala Ile Met Asp Gly Val Glu Cys Ile His Thr 
            340                 345                 350         


Phe Gly Ala Asp Phe Arg Asp Val Arg Gly Phe Leu Ile Gly Asp His 
        355                 360                 365             


Ser Asp Met Phe Asn Gln Lys Ala Glu Leu Thr Asn Gln Gly Pro Gln 
    370                 375                 380                 


Phe Thr Phe Ser Gln Glu Asp Phe Leu Thr Ser Ile Leu Pro Ser Leu 
385                 390                 395                 400 


Thr Glu Ile Asp Thr Val Val Phe Ile Phe Thr Leu Asp Asp Asn Leu 
                405                 410                 415     


Thr Glu Val Gln Thr Ile Val Glu Gln Val Lys Glu Lys Thr Asn His 
            420                 425                 430         


Ile Gln Ala Leu Ala His Ser Thr Val Gly Gln Thr Leu Leu Ile Pro 
        435                 440                 445             


Leu Lys Lys Leu Phe Pro Ser Ile Ile Ser Ile Thr Trp Pro Leu Leu 
    450                 455                 460                 


Phe Phe Glu Tyr Glu Gly Asn Phe Ile Gln Lys Phe Gln Arg Glu Leu 
465                 470                 475                 480 


Ser Thr Lys Trp Val Leu Asn Thr Val Ser Thr Gly Ala His Val Leu 
                485                 490                 495     


Leu Gly Lys Ile Leu Gln Asn His Met Leu Asp Leu Arg Ile Ser Asn 
            500                 505                 510         


Ser Lys Leu Phe Trp Arg Ala Leu Ala Met Leu Gln Arg Phe Ser Gly 
        515                 520                 525             


Gln Ser Lys Ala Arg Cys Ile Glu Ser Leu Leu Arg Ala Ile His Phe 
    530                 535                 540                 


Pro Gln Pro Leu Ser Asp Asp Ile Arg Ala Ala Pro Ile Ser Cys His 
545                 550                 555                 560 


Val Gln Val Ala His Glu Lys Glu Gln Val Ile Pro Ile Ala Leu Leu 
                565                 570                 575     


Ser Leu Leu Phe Arg Cys Ser Ile Thr Glu Ala Gln Ala His Leu Ala 
            580                 585                 590         


Ala Ala Pro Ser Val Cys Glu Ala Val Arg Ser Ala Leu Ala Gly Pro 
        595                 600                 605             


Gly Gln Lys Arg Thr Ala Asp Pro Leu Glu Ile Leu Glu Pro Asp Val 
    610                 615                 620                 


Gln 
625 


<210>  13
<211>  2091
<212>  DNA
<213>  Homo sapiens

<400>  13
aagtgctggg atgacaggtg tgagccaccg cccccggccc ctcgcccgcc ttttgaagga       60

gcctttcgtc ctcaagggcg aggccactcc ccccccgcga gttccatgcc ccctagaggg      120

tcatcgttcc cgacggggag gtggcgccct cccccgggcc ccgggccccg accgcccgtg      180

ctgcctcctt ccgggccctc ctccgcgatg acggcgccgc cagcaggcca ggcggactgg      240

gcggggctcc gagcggggac tgggacccag accgactagg ggactgggag cgggcggcgc      300

ggccatggcg ggctgctgcg ccgcgctggc ggccttcctg ttcgagtacg acacgccgcg      360

catcgtgctc atccgcagcc gcaaagtggg gctcatgaac cgcgccgtgc aactgctcat      420

cctggcctac gtcatcgggt gctaccatcc ccatttggca gaagtggaaa tggagtcccc      480

tagaaggtgg gtgtttgtgt gggaaaaggg ctaccaggaa actgactccg tggtcagctc      540

cgttacgacc aaggtcaagg gcgtggctgt gaccaacact tctaaacttg gattccggat      600

ctgggatgtg gcggattatg tgataccagc tcaggaggaa aactccctct tcgtcatgac      660

caacgtgatc ctcaccatga accagacaca gggcctgtgc cccgagattc cagatgcgac      720

cactgtgtgt aaatcagatg ccagctgtac tgccggctct gccggcaccc acagcaacgg      780

agtctcaaca ggcaggtgcg tagctttcaa cgggtctgtc aagacgtgtg aggtggcggc      840

ctggtgcccg gtggaggatg acacacacgt gccacaacct gcttttttaa aggctgcaga      900

aaacttcact cttttggtta agaacaacat ctggtatccc aaatttaatt tcagcaagag      960

gaatatcctt cccaacatca ccactactta cctcaagtcg tgcatttatg atgctaaaac     1020

agatcccttc tgccccatat tccgtcttgg caaaatagtg gagaacgcag gacacagttt     1080

ccaggacatg gccgtggagg gaggcatcat gggcatccag gtcaactggg actgcaacct     1140

ggacagagcc gcctccctct gcttgcccag gtactccttc cgccgcctcg atacacggga     1200

cgttgagcac aacgtatctc ctggctacaa tttcaggttt gccaagtact acagagacct     1260

ggctggcaac gagcagcgca cgctcatcaa ggcctatggc atccgcttcg acatcattgt     1320

gtttgggaag gcagggaaat ttgacatcat ccccactatg atcaacatcg gctctggcct     1380

ggcactgcta ggcatggcga ccgtgctgtg tgacatcata gtcctctact gcatgaagaa     1440

aagactctac tatcgggaga agaaatataa atatgtggaa gattacgagc agggtcttgc     1500

tagtgagctg gaccagtgag gcctacccca cacctgggct ctccacagcc ccatcaaaga     1560

acagagagga ggaggaggga gaaatggcca ccacatcacc ccagagaaat ttctggaatc     1620

tgattgagtc tccactccac aagcactcag ggttccccag cagctcctgt gtgttgtgtg     1680

caggatctgt ttgcccactc ggcccaggag gtcagcagtc tgttcttggc tgggtcaact     1740

ctgcttttcc cgcaacctgg ggttgtcggg ggagcgctgg cccgacgcag tggcactgct     1800

gtggctttca gggctggagc tggctttgct cagaagcctc ctgtctccag ctctctccag     1860

gacaggccca gtcctctgag gcacggcggc tctgttcaag cactttatgc ggcaggggag     1920

gccgcctggc tgcagtcact agacttgtag caggcctggg ctgcaggctt ccccccgacc     1980

attccctgca gccatgcggc agagctggca tttctcctca gagaagcgct gtgctaaggt     2040

gatcgaggac cagacattaa agcgtgattt tcttaaaaaa aaaaaaaaaa a              2091


<210>  14
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Gly Cys Cys Ala Ala Leu Ala Ala Phe Leu Phe Glu Tyr Asp 
1               5                   10                  15      


Thr Pro Arg Ile Val Leu Ile Arg Ser Arg Lys Val Gly Leu Met Asn 
            20                  25                  30          


Arg Ala Val Gln Leu Leu Ile Leu Ala Tyr Val Ile Gly Cys Tyr His 
        35                  40                  45              


Pro His Leu Ala Glu Val Glu Met Glu Ser Pro Arg Arg Trp Val Phe 
    50                  55                  60                  


Val Trp Glu Lys Gly Tyr Gln Glu Thr Asp Ser Val Val Ser Ser Val 
65                  70                  75                  80  


Thr Thr Lys Val Lys Gly Val Ala Val Thr Asn Thr Ser Lys Leu Gly 
                85                  90                  95      


Phe Arg Ile Trp Asp Val Ala Asp Tyr Val Ile Pro Ala Gln Glu Glu 
            100                 105                 110         


Asn Ser Leu Phe Val Met Thr Asn Val Ile Leu Thr Met Asn Gln Thr 
        115                 120                 125             


Gln Gly Leu Cys Pro Glu Ile Pro Asp Ala Thr Thr Val Cys Lys Ser 
    130                 135                 140                 


Asp Ala Ser Cys Thr Ala Gly Ser Ala Gly Thr His Ser Asn Gly Val 
145                 150                 155                 160 


Ser Thr Gly Arg Cys Val Ala Phe Asn Gly Ser Val Lys Thr Cys Glu 
                165                 170                 175     


Val Ala Ala Trp Cys Pro Val Glu Asp Asp Thr His Val Pro Gln Pro 
            180                 185                 190         


Ala Phe Leu Lys Ala Ala Glu Asn Phe Thr Leu Leu Val Lys Asn Asn 
        195                 200                 205             


Ile Trp Tyr Pro Lys Phe Asn Phe Ser Lys Arg Asn Ile Leu Pro Asn 
    210                 215                 220                 


Ile Thr Thr Thr Tyr Leu Lys Ser Cys Ile Tyr Asp Ala Lys Thr Asp 
225                 230                 235                 240 


Pro Phe Cys Pro Ile Phe Arg Leu Gly Lys Ile Val Glu Asn Ala Gly 
                245                 250                 255     


His Ser Phe Gln Asp Met Ala Val Glu Gly Gly Ile Met Gly Ile Gln 
            260                 265                 270         


Val Asn Trp Asp Cys Asn Leu Asp Arg Ala Ala Ser Leu Cys Leu Pro 
        275                 280                 285             


Arg Tyr Ser Phe Arg Arg Leu Asp Thr Arg Asp Val Glu His Asn Val 
    290                 295                 300                 


Ser Pro Gly Tyr Asn Phe Arg Phe Ala Lys Tyr Tyr Arg Asp Leu Ala 
305                 310                 315                 320 


Gly Asn Glu Gln Arg Thr Leu Ile Lys Ala Tyr Gly Ile Arg Phe Asp 
                325                 330                 335     


Ile Ile Val Phe Gly Lys Ala Gly Lys Phe Asp Ile Ile Pro Thr Met 
            340                 345                 350         


Ile Asn Ile Gly Ser Gly Leu Ala Leu Leu Gly Met Ala Thr Val Leu 
        355                 360                 365             


Cys Asp Ile Ile Val Leu Tyr Cys Met Lys Lys Arg Leu Tyr Tyr Arg 
    370                 375                 380                 


Glu Lys Lys Tyr Lys Tyr Val Glu Asp Tyr Glu Gln Gly Leu Ala Ser 
385                 390                 395                 400 


Glu Leu Asp Gln 
                


<210>  15
<211>  2043
<212>  DNA
<213>  Homo sapiens

<400>  15
aagtgctggg atgacaggtg tgagccaccg cccccggccc ctcgcccgcc ttttgaagga       60

gcctttcgtc ctcaagggcg aggccactcc ccccccgcga gttccatgcc ccctagaggg      120

tcatcgttcc cgacggggag gtggcgccct cccccgggcc ccgggccccg accgcccgtg      180

ctgcctcctt ccgggccctc ctccgcgatg acggcgccgc cagcaggcca ggcggactgg      240

gcggggctcc gagcggggac tgggacccag accgactagg ggactgggag cgggcggcgc      300

ggccatggcg ggctgctgcg ccgcgctggc ggccttcctg ttcgagtacg acacgccgcg      360

catcgtgctc atccgcagcc gcaaagtggg gctcatgaac cgcgccgtgc aactgctcat      420

cctggcctac gtcatcgggt gggtgtttgt gtgggaaaag ggctaccagg aaactgactc      480

cgtggtcagc tccgttacga ccaaggtcaa gggcgtggct gtgaccaaca cttctaaact      540

tggattccgg atctgggatg tggcggatta tgtgatacca gctcaggagg aaaactccct      600

cttcgtcatg accaacgtga tcctcaccat gaaccagaca cagggcctgt gccccgagat      660

tccagatgcg accactgtgt gtaaatcaga tgccagctgt actgccggct ctgccggcac      720

ccacagcaac ggagtctcaa caggcaggtg cgtagctttc aacgggtctg tcaagacgtg      780

tgaggtggcg gcctggtgcc cggtggagga tgacacacac gtgccacaac ctgctttttt      840

aaaggctgca gaaaacttca ctcttttggt taagaacaac atctggtatc ccaaatttaa      900

tttcagcaag aggaatatcc ttcccaacat caccactact tacctcaagt cgtgcattta      960

tgatgctaaa acagatccct tctgccccat attccgtctt ggcaaaatag tggagaacgc     1020

aggacacagt ttccaggaca tggccgtgga gggaggcatc atgggcatcc aggtcaactg     1080

ggactgcaac ctggacagag ccgcctccct ctgcttgccc aggtactcct tccgccgcct     1140

cgatacacgg gacgttgagc acaacgtatc tcctggctac aatttcaggt ttgccaagta     1200

ctacagagac ctggctggca acgagcagcg cacgctcatc aaggcctatg gcatccgctt     1260

cgacatcatt gtgtttggga aggcagggaa atttgacatc atccccacta tgatcaacat     1320

cggctctggc ctggcactgc taggcatggc gaccgtgctg tgtgacatca tagtcctcta     1380

ctgcatgaag aaaagactct actatcggga gaagaaatat aaatatgtgg aagattacga     1440

gcagggtctt gctagtgagc tggaccagtg aggcctaccc cacacctggg ctctccacag     1500

ccccatcaaa gaacagagag gaggaggagg gagaaatggc caccacatca ccccagagaa     1560

atttctggaa tctgattgag tctccactcc acaagcactc agggttcccc agcagctcct     1620

gtgtgttgtg tgcaggatct gtttgcccac tcggcccagg aggtcagcag tctgttcttg     1680

gctgggtcaa ctctgctttt cccgcaacct ggggttgtcg ggggagcgct ggcccgacgc     1740

agtggcactg ctgtggcttt cagggctgga gctggctttg ctcagaagcc tcctgtctcc     1800

agctctctcc aggacaggcc cagtcctctg aggcacggcg gctctgttca agcactttat     1860

gcggcagggg aggccgcctg gctgcagtca ctagacttgt agcaggcctg ggctgcaggc     1920

ttccccccga ccattccctg cagccatgcg gcagagctgg catttctcct cagagaagcg     1980

ctgtgctaag gtgatcgagg accagacatt aaagcgtgat tttcttaaaa aaaaaaaaaa     2040

aaa                                                                   2043


<210>  16
<211>  388
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ala Gly Cys Cys Ala Ala Leu Ala Ala Phe Leu Phe Glu Tyr Asp 
1               5                   10                  15      


Thr Pro Arg Ile Val Leu Ile Arg Ser Arg Lys Val Gly Leu Met Asn 
            20                  25                  30          


Arg Ala Val Gln Leu Leu Ile Leu Ala Tyr Val Ile Gly Trp Val Phe 
        35                  40                  45              


Val Trp Glu Lys Gly Tyr Gln Glu Thr Asp Ser Val Val Ser Ser Val 
    50                  55                  60                  


Thr Thr Lys Val Lys Gly Val Ala Val Thr Asn Thr Ser Lys Leu Gly 
65                  70                  75                  80  


Phe Arg Ile Trp Asp Val Ala Asp Tyr Val Ile Pro Ala Gln Glu Glu 
                85                  90                  95      


Asn Ser Leu Phe Val Met Thr Asn Val Ile Leu Thr Met Asn Gln Thr 
            100                 105                 110         


Gln Gly Leu Cys Pro Glu Ile Pro Asp Ala Thr Thr Val Cys Lys Ser 
        115                 120                 125             


Asp Ala Ser Cys Thr Ala Gly Ser Ala Gly Thr His Ser Asn Gly Val 
    130                 135                 140                 


Ser Thr Gly Arg Cys Val Ala Phe Asn Gly Ser Val Lys Thr Cys Glu 
145                 150                 155                 160 


Val Ala Ala Trp Cys Pro Val Glu Asp Asp Thr His Val Pro Gln Pro 
                165                 170                 175     


Ala Phe Leu Lys Ala Ala Glu Asn Phe Thr Leu Leu Val Lys Asn Asn 
            180                 185                 190         


Ile Trp Tyr Pro Lys Phe Asn Phe Ser Lys Arg Asn Ile Leu Pro Asn 
        195                 200                 205             


Ile Thr Thr Thr Tyr Leu Lys Ser Cys Ile Tyr Asp Ala Lys Thr Asp 
    210                 215                 220                 


Pro Phe Cys Pro Ile Phe Arg Leu Gly Lys Ile Val Glu Asn Ala Gly 
225                 230                 235                 240 


His Ser Phe Gln Asp Met Ala Val Glu Gly Gly Ile Met Gly Ile Gln 
                245                 250                 255     


Val Asn Trp Asp Cys Asn Leu Asp Arg Ala Ala Ser Leu Cys Leu Pro 
            260                 265                 270         


Arg Tyr Ser Phe Arg Arg Leu Asp Thr Arg Asp Val Glu His Asn Val 
        275                 280                 285             


Ser Pro Gly Tyr Asn Phe Arg Phe Ala Lys Tyr Tyr Arg Asp Leu Ala 
    290                 295                 300                 


Gly Asn Glu Gln Arg Thr Leu Ile Lys Ala Tyr Gly Ile Arg Phe Asp 
305                 310                 315                 320 


Ile Ile Val Phe Gly Lys Ala Gly Lys Phe Asp Ile Ile Pro Thr Met 
                325                 330                 335     


Ile Asn Ile Gly Ser Gly Leu Ala Leu Leu Gly Met Ala Thr Val Leu 
            340                 345                 350         


Cys Asp Ile Ile Val Leu Tyr Cys Met Lys Lys Arg Leu Tyr Tyr Arg 
        355                 360                 365             


Glu Lys Lys Tyr Lys Tyr Val Glu Asp Tyr Glu Gln Gly Leu Ala Ser 
    370                 375                 380                 


Glu Leu Asp Gln 
385             


<210>  17
<211>  2023
<212>  DNA
<213>  Homo sapiens

<400>  17
aagtgctggg atgacaggtg tgagccaccg cccccggccc ctcgcccgcc ttttgaagga       60

gcctttcgtc ctcaagggcg aggccactcc ccccccgcga gttccatgcc ccctagaggg      120

tcatcgttcc cgacggggag gtggcgccct cccccgggcc ccgggccccg accgcccgtg      180

ctgcctcctt ccgggccctc ctccgcgatg acggcgccgc cagcaggcca ggcggactgg      240

gcggggctcc gagcggggac tgggacccag accgactagg ggactgggag cgggcggcgc      300

ggccatggcg ggctgctgcg ccgcgctggc ggccttcctg ttcgagtacg acacgccgcg      360

catcgtgctc atccgcagcc gcaaagtggg gctcatgaac cgcgccgtgc aactgctcat      420

cctggcctac gtcatcgggt gggtgtttgt gtgggaaaag ggctaccagg aaactgactc      480

cgtggtcagc tccgttacga ccaaggtcaa gggcgtggct gtgaccaaca cttctaaact      540

tggattccgg atctgggatg tggcggatta tgtgatacca gctcaggagg aaaactccct      600

cttcgtcatg accaacgtga tcctcaccat gaaccagaca cagggcctgt gccccgagat      660

tccagatgcg accactgtgt gtaaatcaga tgccagctgt actgccggct ctgccggcac      720

ccacagcaac ggagtctcaa caggcagacc tgctttttta aaggctgcag aaaacttcac      780

tcttttggtt aagaacaaca tctggtatcc caaatttaat ttcagcaaga ggaatatcct      840

tcccaacatc accactactt acctcaagtc gtgcatttat gatgctaaaa cagatccctt      900

ctgccccata ttccgtcttg gcaaaatagt ggagaacgca ggacacagtt tccaggacat      960

ggccgtggag ggaggcatca tgggcatcca ggtcaactgg gactgcaacc tggacagagc     1020

cgcctccctc tgcttgccca ggtactcctt ccgccgcctc gatacacggg acgttgagca     1080

caacgtatct cctggctaca atttcaggtt tgccaagtac tacagagacc tggctggcaa     1140

cgagcagcgc acgctcatca aggcctatgg catccgcttc gacatcattg tgtttgggaa     1200

ggcagggaaa tttgacatca tccccactat gatcaacatc ggctctggcc tggcactgct     1260

aggcatggcg accgtgctgt gtgacatcat agtcctctac tgcatgaaga aaagactcta     1320

ctatcgggag aagaaatata aatatgtgga agattacgag cagggtcttg ctagtgagct     1380

ggaccagtga ggcctacccc acacctgggc tctccacagc cccatcaaag aacagagagg     1440

aggaggaggg agaaatggcc accacatcac cccagagaaa tttctggaat ctgattgagt     1500

ctccactcca caagcactca gggttcccca gcagctcctg tgtgttgtgt gcaggatctg     1560

tttgcccact cggcccagga ggtcagcagt ctgttcttgg ctgggtcaac tctgcttttc     1620

ccgcaacctg gggttgtcgg gggagcgctg gcccgacgca gtggcactgc tgtggctttc     1680

agggctggag ctggctttgc tcagaagcct cctgtctcca gctctctcca ggacaggccc     1740

agtcctctga ggcacggcgg ctctgttcaa gcactttatg cggcagggga ggccgcctgg     1800

ctgcagtcac tagacttgta gcaggcctgg gctgcaggct tccccccgac cattccctgc     1860

agccatgcgg cagagctggc atttctcctc agagaagcgc tgtgctaagg tgatcgagga     1920

ccagacatta aagcgtgatt ttcttaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1980

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa                       2023


<210>  18
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Gly Cys Cys Ala Ala Leu Ala Ala Phe Leu Phe Glu Tyr Asp 
1               5                   10                  15      


Thr Pro Arg Ile Val Leu Ile Arg Ser Arg Lys Val Gly Leu Met Asn 
            20                  25                  30          


Arg Ala Val Gln Leu Leu Ile Leu Ala Tyr Val Ile Gly Trp Val Phe 
        35                  40                  45              


Val Trp Glu Lys Gly Tyr Gln Glu Thr Asp Ser Val Val Ser Ser Val 
    50                  55                  60                  


Thr Thr Lys Val Lys Gly Val Ala Val Thr Asn Thr Ser Lys Leu Gly 
65                  70                  75                  80  


Phe Arg Ile Trp Asp Val Ala Asp Tyr Val Ile Pro Ala Gln Glu Glu 
                85                  90                  95      


Asn Ser Leu Phe Val Met Thr Asn Val Ile Leu Thr Met Asn Gln Thr 
            100                 105                 110         


Gln Gly Leu Cys Pro Glu Ile Pro Asp Ala Thr Thr Val Cys Lys Ser 
        115                 120                 125             


Asp Ala Ser Cys Thr Ala Gly Ser Ala Gly Thr His Ser Asn Gly Val 
    130                 135                 140                 


Ser Thr Gly Arg Pro Ala Phe Leu Lys Ala Ala Glu Asn Phe Thr Leu 
145                 150                 155                 160 


Leu Val Lys Asn Asn Ile Trp Tyr Pro Lys Phe Asn Phe Ser Lys Arg 
                165                 170                 175     


Asn Ile Leu Pro Asn Ile Thr Thr Thr Tyr Leu Lys Ser Cys Ile Tyr 
            180                 185                 190         


Asp Ala Lys Thr Asp Pro Phe Cys Pro Ile Phe Arg Leu Gly Lys Ile 
        195                 200                 205             


Val Glu Asn Ala Gly His Ser Phe Gln Asp Met Ala Val Glu Gly Gly 
    210                 215                 220                 


Ile Met Gly Ile Gln Val Asn Trp Asp Cys Asn Leu Asp Arg Ala Ala 
225                 230                 235                 240 


Ser Leu Cys Leu Pro Arg Tyr Ser Phe Arg Arg Leu Asp Thr Arg Asp 
                245                 250                 255     


Val Glu His Asn Val Ser Pro Gly Tyr Asn Phe Arg Phe Ala Lys Tyr 
            260                 265                 270         


Tyr Arg Asp Leu Ala Gly Asn Glu Gln Arg Thr Leu Ile Lys Ala Tyr 
        275                 280                 285             


Gly Ile Arg Phe Asp Ile Ile Val Phe Gly Lys Ala Gly Lys Phe Asp 
    290                 295                 300                 


Ile Ile Pro Thr Met Ile Asn Ile Gly Ser Gly Leu Ala Leu Leu Gly 
305                 310                 315                 320 


Met Ala Thr Val Leu Cys Asp Ile Ile Val Leu Tyr Cys Met Lys Lys 
                325                 330                 335     


Arg Leu Tyr Tyr Arg Glu Lys Lys Tyr Lys Tyr Val Glu Asp Tyr Glu 
            340                 345                 350         


Gln Gly Leu Ala Ser Glu Leu Asp Gln 
        355                 360     


<210>  19
<211>  1796
<212>  DNA
<213>  Homo sapiens

<400>  19
aagtgctggg atgacaggtg tgagccaccg cccccggccc ctcgcccgcc ttttgaagga       60

gcctttcgtc ctcaagggcg aggccactcc ccccccgcga gttccatgcc ccctagaggg      120

tcatcgttcc cgacggggag gtggcgccct cccccgggcc ccgggccccg accgcccgtg      180

ctgcctcctt ccgggccctc ctccgcgatg acggcgccgc cagcaggcca ggcggactgg      240

gcggggctcc gagcggggac tgggacccag accgactagg ggactgggag cgggcggcgc      300

ggccatggcg ggctgctgcg ccgcgctggc ggccttcctg ttcgagtacg acacgccgcg      360

catcgtgctc atccgcagcc gcaaagtggg gctcatgaac cgcgccgtgc aactgctcat      420

cctggcctac gtcatcgggt gggtgtttgt gtgggaaaag ggctaccagg aaactgactc      480

cgtggtcagc tccgttacga ccaaggtcaa gggcgtggct gtgaccaaca cttctaaact      540

tggattccgg atctgggatg tggcggatta tgtgatacca gctcaggagg aaaactccct      600

cttcgtcatg accaacgtga tcctcaccat gaaccagaca cagggcctgt gccccgagat      660

tccagatgcg accactgtgt gtaaatcaga tgccagctgt actgccggct ctgccggcac      720

ccacagcaac ggagtctcaa caggcaggtg cgtagctttc aacgggtctg tcaagacgtg      780

tgaggtggcg gcctggtgcc cggtggagga tgacacacac gtgccacaac ctgctttttt      840

aaaggctgca gaaaacttca ctcttttggt taagaacaac atctggtatc ccaaatttaa      900

tttcagcaag aggaatatcc ttcccaacat caccactact tacctcaagt cgtgcattta      960

tgatgctaaa acagatccct tctgccccat attccgtctt ggcaaaatag tggagaacgc     1020

aggacacagt ttccaggaca tggccgtgga gggaggcatc atgggcatcc aggtcaactg     1080

ggactgcaac ctggacagag ccgcctccct ctgcttgccc aggtactcct tccgccgcct     1140

cgatacacgg gacgttgagc acaacgtatc tcctggctac aatttcaggt ttgccaagta     1200

ctacagagac ctggctggca acgagcagcg cacgctcatc aaggcctatg gcatccgctt     1260

cgacatcatt gtgtttggga aggcagggaa atttgacatc accccagaga aatttctgga     1320

atctgattga gtctccactc cacaagcact cagggttccc cagcagctcc tgtgtgttgt     1380

gtgcaggatc tgtttgccca ctcggcccag gaggtcagca gtctgttctt ggctgggtca     1440

actctgcttt tcccgcaacc tggggttgtc gggggagcgc tggcccgacg cagtggcact     1500

gctgtggctt tcagggctgg agctggcttt gctcagaagc ctcctgtctc cagctctctc     1560

caggacaggc ccagtcctct gaggcacggc ggctctgttc aagcacttta tgcggcaggg     1620

gaggccgcct ggctgcagtc actagacttg tagcaggcct gggctgcagg cttccccccg     1680

accattccct gcagccatgc ggcagagctg gcatttctcc tcagagaagc gctgtgctaa     1740

ggtgatcgag gaccagacat taaagcgtga ttttcttaaa aaaaaaaaaa aaaaaa         1796


<210>  20
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Gly Cys Cys Ala Ala Leu Ala Ala Phe Leu Phe Glu Tyr Asp 
1               5                   10                  15      


Thr Pro Arg Ile Val Leu Ile Arg Ser Arg Lys Val Gly Leu Met Asn 
            20                  25                  30          


Arg Ala Val Gln Leu Leu Ile Leu Ala Tyr Val Ile Gly Trp Val Phe 
        35                  40                  45              


Val Trp Glu Lys Gly Tyr Gln Glu Thr Asp Ser Val Val Ser Ser Val 
    50                  55                  60                  


Thr Thr Lys Val Lys Gly Val Ala Val Thr Asn Thr Ser Lys Leu Gly 
65                  70                  75                  80  


Phe Arg Ile Trp Asp Val Ala Asp Tyr Val Ile Pro Ala Gln Glu Glu 
                85                  90                  95      


Asn Ser Leu Phe Val Met Thr Asn Val Ile Leu Thr Met Asn Gln Thr 
            100                 105                 110         


Gln Gly Leu Cys Pro Glu Ile Pro Asp Ala Thr Thr Val Cys Lys Ser 
        115                 120                 125             


Asp Ala Ser Cys Thr Ala Gly Ser Ala Gly Thr His Ser Asn Gly Val 
    130                 135                 140                 


Ser Thr Gly Arg Cys Val Ala Phe Asn Gly Ser Val Lys Thr Cys Glu 
145                 150                 155                 160 


Val Ala Ala Trp Cys Pro Val Glu Asp Asp Thr His Val Pro Gln Pro 
                165                 170                 175     


Ala Phe Leu Lys Ala Ala Glu Asn Phe Thr Leu Leu Val Lys Asn Asn 
            180                 185                 190         


Ile Trp Tyr Pro Lys Phe Asn Phe Ser Lys Arg Asn Ile Leu Pro Asn 
        195                 200                 205             


Ile Thr Thr Thr Tyr Leu Lys Ser Cys Ile Tyr Asp Ala Lys Thr Asp 
    210                 215                 220                 


Pro Phe Cys Pro Ile Phe Arg Leu Gly Lys Ile Val Glu Asn Ala Gly 
225                 230                 235                 240 


His Ser Phe Gln Asp Met Ala Val Glu Gly Gly Ile Met Gly Ile Gln 
                245                 250                 255     


Val Asn Trp Asp Cys Asn Leu Asp Arg Ala Ala Ser Leu Cys Leu Pro 
            260                 265                 270         


Arg Tyr Ser Phe Arg Arg Leu Asp Thr Arg Asp Val Glu His Asn Val 
        275                 280                 285             


Ser Pro Gly Tyr Asn Phe Arg Phe Ala Lys Tyr Tyr Arg Asp Leu Ala 
    290                 295                 300                 


Gly Asn Glu Gln Arg Thr Leu Ile Lys Ala Tyr Gly Ile Arg Phe Asp 
305                 310                 315                 320 


Ile Ile Val Phe Gly Lys Ala Gly Lys Phe Asp Ile Thr Pro Glu Lys 
                325                 330                 335     


Phe Leu Glu Ser Asp 
            340     


<210>  21
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  control shRNA shNT#1

<400>  21
ccggcaacaa gatgaagagc accaactcga gttggtgctc ttcatcttgt tgttttt          57


<210>  22
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  control shRNA shNT#2

<400>  22
ccggcaacaa gatgaagagc accaactcga gttggtgctc ttcatcttgt tgttttt          57


<210>  23
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA shPADI4#1

<400>  23
ccggctgaag gagtttccca tcaaactcga gtttgatggg aaactccttc agtttttg         58


<210>  24
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA shPADI4#2

<400>  24
ccggagacat tgagagaaca taattctcga gaattatgtt ctctcaatgt ctttttttg        59


<210>  25
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA shPADI4#3

<400>  25
ccggtgacta ctctggccat gaaagctcga gctttcatgg ccagagtagt cattttttg        59


<210>  26
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA shPADI4#4

<400>  26
ccggccaggt ctgagatgga caaagctcga gctttgtcca tctcagacct ggttttttg        59


<210>  27
<211>  59
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  shRNA shPADI4#5

<400>  27
ccggagcaag agctcttgtg aatatctcga gatattcaca agagctcttg ctttttttg        59


