                         SEQUENCE LISTING

<110>  MEDICAGO INC.
 
<120>  Modified CPMV Enhancer Elements

<130>  V86817WO

<150>  US 61/971,274
<151>  2014-03-27

<150>  PCT/CA04/050326
<151>  2014-03-28

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression enhancer comprising CPMV HT+

<400>  1
tattaaaatc ttaataggtt ttgataaaag cgaacgtggg gaaacccgaa ccaaaccttc       60

ttctaaactc tctctcatct ctcttaaagc aaacttctct cttgtctttc ttgcgtgagc      120

gatcttcaac gttgtcagat cgtgcttcgg caccagtaca acgttttctt tcactgaagc      180

gaaatcaaag atctctttgt ggacacgtag tgcggcgcca ttaaataacg tgtacttgtc      240

ctattcttgt cggtgtggtc ttgggaaaag aaagcttgct ggaggctgct gttcagcccc      300

atacattact tgttacgatt ctgctgactt tcggcgggtg caatatctct acttctgctt      360

gacgaggtat tgttgcctgt acttctttct tcttcttctt gctgattggt tctataagaa      420

atctagtatt ttctttgaaa cagagttttc ccgtggtttt cgaacttgga gaaagattgt      480

taagcttctg tatattctgc ccaaatttgt tcgggcccaa taccgcggag aaaa            534


<210>  2
<211>  517
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression enhancer CPMV HT

<400>  2
tattaaaatc ttaataggtt ttgataaaag cgaacgtggg gaaacccgaa ccaaaccttc       60

ttctaaactc tctctcatct ctcttaaagc aaacttctct cttgtctttc ttgcgtgagc      120

gatcttcaac gttgtcagat cgtgcttcgg caccagtaca acgttttctt tcactgaagc      180

gaaatcaaag atctctttgt ggacacgtag tgcggcgcca ttaaataacg tgtacttgtc      240

ctattcttgt cggtgtggtc ttgggaaaag aaagcttgct ggaggctgct gttcagcccc      300

atacattact tgttacgatt ctgctgactt tcggcgggtg caatatctct acttctgctt      360

gacgaggtat tgttgcctgt acttctttct tcttcttctt gctgattggt tctataagaa      420

atctagtatt ttctttgaaa cagagttttc ccgtggtttt cgaacttgga gaaagattgt      480

taagcttctg tatattctgc ccaaatttgt cgggccc                               517


<210>  3
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CPMV HT+[WT115]

<400>  3
tattaaaatc ttaataggtt ttgataaaag cgaacgtggg gaaacccgaa ccaaaccttc       60

ttctaaactc tctctcatct ctcttaaagc aaacttctct cttgtctttc ttgcatgagc      120

gatcttcaac gttgtcagat cgtgcttcgg caccagtaca acgttttctt tcactgaagc      180

gaaatcaaag atctctttgt ggacacgtag tgcggcgcca ttaaataacg tgtacttgtc      240

ctattcttgt cggtgtggtc ttgggaaaag aaagcttgct ggaggctgct gttcagcccc      300

atacattact tgttacgatt ctgctgactt tcggcgggtg caatatctct acttctgctt      360

gacgaggtat tgttgcctgt acttctttct tcttcttctt gctgattggt tctataagaa      420

atctagtatt ttctttgaaa cagagttttc ccgtggtttt cgaacttgga gaaagattgt      480

taagcttctg tatattctgc ccaaatttgt tcgggcccaa taccgcggag aaaa            534


<210>  4
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CPMV HT+ (plant kozak consensus sequence)


<220>
<221>  misc_feature
<222>  (529)..(529)

<220>
<221>  misc_feature
<222>  (529)..(529)
<223>  a may be present or absent

<400>  4
tattaaaatc ttaataggtt ttgataaaag cgaacgtggg gaaacccgaa ccaaaccttc       60

ttctaaactc tctctcatct ctcttaaagc aaacttctct cttgtctttc ttgcgtgagc      120

gatcttcaac gttgtcagat cgtgcttcgg caccagtaca acgttttctt tcactgaagc      180

gaaatcaaag atctctttgt ggacacgtag tgcggcgcca ttaaataacg tgtacttgtc      240

ctattcttgt cggtgtggtc ttgggaaaag aaagcttgct ggaggctgct gttcagcccc      300

atacattact tgttacgatt ctgctgactt tcggcgggtg caatatctct acttctgctt      360

gacgaggtat tgttgcctgt acttctttct tcttcttctt gctgattggt tctataagaa      420

atctagtatt ttctttgaaa cagagttttc ccgtggtttt cgaacttgga gaaagattgt      480

taagcttctg tatattctgc ccaaatttgt tcgggcccaa taccgcggna rrma            534


<210>  5

<400>  5
000

<210>  6

<400>  6
000

<210>  7

<400>  7
000

<210>  8

<400>  8
000

<210>  9

<400>  9
000

<210>  10

<400>  10
000

<210>  11

<400>  11
000

<210>  12

<400>  12
000

<210>  13

<400>  13
000

<210>  14

<400>  14
000

<210>  15

<400>  15
000

<210>  16

<400>  16
000

<210>  17

<400>  17
000

<210>  18
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF-PDI.S1+3c

<400>  18
aaatttgtcg ggcccatggc gaaaaacgtt gcgattttcg gcttattg                    48


<210>  19
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF-H3V36111.s1-4r

<400>  19
actaaagaaa ataggccttc aaatgcaaat gttgcaccta atgttgccct t                51


<210>  20
<211>  1725
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of PDISP/H3 Victoria

<400>  20
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cccaaaaact tcctggaaat gacaacagca cggcaacgct gtgccttggg      120

caccatgcag taccaaacgg aacgatagtg aaaacaatca cgaatgacca aattgaagtt      180

actaatgcta ctgagctggt tcagaattcc tcaataggtg aaatatgcga cagtcctcat      240

cagatccttg atggagaaaa ctgcacacta atagatgctc tattgggaga ccctcagtgt      300

gatggcttcc aaaataagaa atgggacctt tttgttgaac gaagcaaagc ctacagcaac      360

tgttaccctt atgatgtgcc ggattatgcc tcccttaggt cactagttgc ctcatccggc      420

acactggagt ttaacaatga aagcttcaat tggactggag tcactcaaaa cggaacaagt      480

tctgcttgca taaggagatc taataatagt ttctttagta gattaaattg gttgacccac      540

ttaaacttca aatacccagc attgaacgtg actatgccaa acaatgaaca atttgacaaa      600

ttgtacattt ggggggttca ccacccgggt acggacaagg accaaatctt cctgtatgct      660

caatcatcag gaagaatcac agtatctacc aaaagaagcc aacaagctgt aatcccgaat      720

atcggatcta gacccagaat aaggaatatc cctagcagaa taagcatcta ttggacaata      780

gtaaaaccgg gagacatact tttgattaac agcacaggga atctaattgc tcctaggggt      840

tacttcaaaa tacgaagtgg gaaaagctca ataatgagat cagatgcacc cattggcaaa      900

tgcaattctg aatgcatcac tccaaatgga agcattccca atgacaaacc attccaaaat      960

gtaaacagga tcacatacgg ggcctgtccc agatatgtta agcaaagcac tctgaaattg     1020

gcaacaggaa tgcgaaatgt accagagaaa caaactagag gcatatttgg cgcaatagcg     1080

ggtttcatag aaaatggttg ggagggaatg gtggatggtt ggtacggttt caggcatcaa     1140

aattctgagg gaagaggaca agcagcagat ctcaaaagca ctcaagcagc aatcgatcaa     1200

atcaatggga agctgaatcg attgatcggg aaaaccaacg agaaattcca tcagattgaa     1260

aaagaattct cagaagtcga agggagaatt caggaccttg agaaatatgt tgaggacact     1320

aaaatagatc tctggtcata caacgcggag cttcttgttg ccctggagaa ccaacataca     1380

attgatctaa ctgactcaga aatgaacaaa ctgtttgaaa aaacaaagaa gcaactaagg     1440

gaaaatgctg aggatatggg caatggttgt ttcaaaatat accacaaatg tgacaatgcc     1500

tgcataggat caatcagaaa tggaacttat gaccacgatg tatacagaga tgaagcatta     1560

aacaaccggt tccagatcaa gggagttgag ctgaagtcag ggtacaaaga ttggatccta     1620

tggatttcct ttgccatatc atgttttttg ctttgtgttg ctttgttggg gttcatcatg     1680

tgggcctgcc aaaagggcaa cattaggtgc aacatttgca tttga                     1725


<210>  21
<211>  4903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of construct 1191

<400>  21
tggcaggata tattgtggtg taaacaaatt gacgcttaga caacttaata acacattgcg       60

gacgttttta atgtactgaa ttaacgccga atcccgggct ggtatattta tatgttgtca      120

aataactcaa aaaccataaa agtttaagtt agcaagtgtg tacattttta cttgaacaaa      180

aatattcacc tactactgtt ataaatcatt attaaacatt agagtaaaga aatatggatg      240

ataagaacaa gagtagtgat attttgacaa caattttgtt gcaacatttg agaaaatttt      300

gttgttctct cttttcattg gtcaaaaaca atagagagag aaaaaggaag agggagaata      360

aaaacataat gtgagtatga gagagaaagt tgtacaaaag ttgtaccaaa atagttgtac      420

aaatatcatt gaggaatttg acaaaagcta cacaaataag ggttaattgc tgtaaataaa      480

taaggatgac gcattagaga gatgtaccat tagagaattt ttggcaagtc attaaaaaga      540

aagaataaat tatttttaaa attaaaagtt gagtcatttg attaaacatg tgattattta      600

atgaattgat gaaagagttg gattaaagtt gtattagtaa ttagaatttg gtgtcaaatt      660

taatttgaca tttgatcttt tcctatatat tgccccatag agtcagttaa ctcattttta      720

tatttcatag atcaaataag agaaataacg gtatattaat ccctccaaaa aaaaaaaacg      780

gtatatttac taaaaaatct aagccacgta ggaggataac aggatccccg taggaggata      840

acatccaatc caaccaatca caacaatcct gatgagataa cccactttaa gcccacgcat      900

ctgtggcaca tctacattat ctaaatcaca cattcttcca cacatctgag ccacacaaaa      960

accaatccac atctttatca cccattctat aaaaaatcac actttgtgag tctacacttt     1020

gattcccttc aaacacatac aaagagaaga gactaattaa ttaattaatc atcttgagag     1080

aaaatggaac gagctataca aggaaacgac gctagggaac aagctaacag tgaacgttgg     1140

gatggaggat caggaggtac cacttctccc ttcaaacttc ctgacgaaag tccgagttgg     1200

actgagtggc ggctacataa cgatgagacg aattcgaatc aagataatcc ccttggtttc     1260

aaggaaagct ggggtttcgg gaaagttgta tttaagagat atctcagata cgacaggacg     1320

gaagcttcac tgcacagagt ccttggatct tggacgggag attcggttaa ctatgcagca     1380

tctcgatttt tcggtttcga ccagatcgga tgtacctata gtattcggtt tcgaggagtt     1440

agtatcaccg tttctggagg gtcgcgaact cttcagcatc tctgtgagat ggcaattcgg     1500

tctaagcaag aactgctaca gcttgcccca atcgaagtgg aaagtaatgt atcaagagga     1560

tgccctgaag gtactcaaac cttcgaaaaa gaaagcgagt aagttaaaat gcttcttcgt     1620

ctcctattta taatatggtt tgttattgtt aattttgttc ttgtagaaga gcttaattaa     1680

tcgttgttgt tatgaaatac tatttgtatg agatgaactg gtgtaatgta attcatttac     1740

ataagtggag tcagaatcag aatgtttcct ccataactaa ctagacatga agacctgccg     1800

cgtacaattg tcttatattt gaacaactaa aattgaacat cttttgccac aactttataa     1860

gtggttaata tagctcaaat atatggtcaa gttcaataga ttaataatgg aaatatcagt     1920

tatcgaaatt cattaacaat caacttaacg ttattaacta ctaattttat atcatcccct     1980

ttgataaatg atagtacacc aattaggaag gagcatgctc gcctaggaga ttgtcgtttc     2040

ccgccttcag tttgcaagct gctctagccg tgtagccaat acgcaaaccg cctctccccg     2100

cgcgttggga attactagcg cgtgtcgaca agcttgcatg ccggtcaaca tggtggagca     2160

cgacacactt gtctactcca aaaatatcaa agatacagtc tcagaagacc aaagggcaat     2220

tgagactttt caacaaaggg taatatccgg aaacctcctc ggattccatt gcccagctat     2280

ctgtcacttt attgtgaaga tagtggaaaa ggaaggtggc tcctacaaat gccatcattg     2340

cgataaagga aaggccatcg ttgaagatgc ctctgccgac agtggtccca aagatggacc     2400

cccacccacg aggagcatcg tggaaaaaga agacgttcca accacgtctt caaagcaagt     2460

ggattgatgt gataacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga     2520

tacagtctca gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa     2580

cctcctcgga ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga     2640

aggtggctcc tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc     2700

tgccgacagt ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga     2760

cgttccaacc acgtcttcaa agcaagtgga ttgatgtgat atctccactg acgtaaggga     2820

tgacgcacaa tcccactatc cttcgcaaga cccttcctct atataaggaa gttcatttca     2880

tttggagagg tattaaaatc ttaataggtt ttgataaaag cgaacgtggg gaaacccgaa     2940

ccaaaccttc ttctaaactc tctctcatct ctcttaaagc aaacttctct cttgtctttc     3000

ttgcgtgagc gatcttcaac gttgtcagat cgtgcttcgg caccagtaca acgttttctt     3060

tcactgaagc gaaatcaaag atctctttgt ggacacgtag tgcggcgcca ttaaataacg     3120

tgtacttgtc ctattcttgt cggtgtggtc ttgggaaaag aaagcttgct ggaggctgct     3180

gttcagcccc atacattact tgttacgatt ctgctgactt tcggcgggtg caatatctct     3240

acttctgctt gacgaggtat tgttgcctgt acttctttct tcttcttctt gctgattggt     3300

tctataagaa atctagtatt ttctttgaaa cagagttttc ccgtggtttt cgaacttgga     3360

gaaagattgt taagcttctg tatattctgc ccaaatttgt cgggcccgcg gatggcgaaa     3420

aacgttgcga ttttcggctt attgttttct cttcttgtgt tggttccttc tcagatcttc     3480

gcctgcaggc tcctcagcca aaacgacacc cccatctgtc tatccactgg cccctggatc     3540

tgctgcccaa actaactcca tggtgaccct gggatgcctg gtcaagggct atttccctga     3600

gccagtgaca gtgacctgga actctggatc cctgtccagc ggtgtgcaca ccttcccagc     3660

tgtcctgcag tctgacctct acactctgag cagctcagtg actgtcccct ccagcacctg     3720

gcccagcgag accgtcacct gcaacgttgc ccacccggcc agcagcacca aggtggacaa     3780

gaaaattgtg cccagggatt gtggttgtaa gccttgcata tgtacagtcc cagaagtatc     3840

atctgtcttc atcttccccc caaagcccaa ggatgtgctc accattactc tgactcctaa     3900

ggtcacgtgt gttgtggtag acatcagcaa ggatgatccc gaggtccagt tcagctggtt     3960

tgtagatgat gtggaggtgc acacagctca gacgcaaccc cgggaggagc agttcaacag     4020

cactttccgc tcagtcagtg aacttcccat catgcaccag gactggctca atggcaagga     4080

gcgatcgctc accatcacca tcaccatcac catcaccatt aaaggcctat tttctttagt     4140

ttgaatttac tgttattcgg tgtgcatttc tatgtttggt gagcggtttt ctgtgctcag     4200

agtgtgttta ttttatgtaa tttaatttct ttgtgagctc ctgtttagca ggtcgtccct     4260

tcagcaagga cacaaaaaga ttttaatttt attaaaaaaa aaaaaaaaaa agaccgggaa     4320

ttcgatatca agcttatcga cctgcagatc gttcaaacat ttggcaataa agtttcttaa     4380

gattgaatcc tgttgccggt cttgcgatga ttatcatata atttctgttg aattacgtta     4440

agcatgtaat aattaacatg taatgcatga cgttatttat gagatgggtt tttatgatta     4500

gagtcccgca attatacatt taatacgcga tagaaaacaa aatatagcgc gcaaactagg     4560

ataaattatc gcgcgcggtg tcatctatgt tactagatct ctagagtctc aagcttggcg     4620

cgcccacgtg actagtggca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg     4680

gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg     4740

aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgctaga     4800

gcagcttgag cttggatcag attgtcgttt cccgccttca gtttaaacta tcagtgtttg     4860

acaggatata ttggcgggta aacctaagag aaaagagcgt tta                       4903


<210>  22
<211>  3465
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of expression cassette 1391

<400>  22
gtcaacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga tacagtctca       60

gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa cctcctcgga      120

ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga cgttccaacc      300

acgtcttcaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac acttgtctac      360

tccaaaaata tcaaagatac agtctcagaa gaccaaaggg caattgagac ttttcaacaa      420

agggtaatat ccggaaacct cctcggattc cattgcccag ctatctgtca ctttattgtg      480

aagatagtgg aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggcc      540

atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggtat taaaatctta ataggttttg ataaaagcga      780

acgtggggaa acccgaacca aaccttcttc taaactctct ctcatctctc ttaaagcaaa      840

cttctctctt gtctttcttg cgtgagcgat cttcaacgtt gtcagatcgt gcttcggcac      900

cagtacaacg ttttctttca ctgaagcgaa atcaaagatc tctttgtgga cacgtagtgc      960

ggcgccatta aataacgtgt acttgtccta ttcttgtcgg tgtggtcttg ggaaaagaaa     1020

gcttgctgga ggctgctgtt cagccccata cattacttgt tacgattctg ctgactttcg     1080

gcgggtgcaa tatctctact tctgcttgac gaggtattgt tgcctgtact tctttcttct     1140

tcttcttgct gattggttct ataagaaatc tagtattttc tttgaaacag agttttcccg     1200

tggttttcga acttggagaa agattgttaa gcttctgtat attctgccca aatttgtcgg     1260

gcccatggcg aaaaacgttg cgattttcgg cttattgttt tctcttcttg tgttggttcc     1320

ttctcagatc ttcgcccaaa aacttcctgg aaatgacaac agcacggcaa cgctgtgcct     1380

tgggcaccat gcagtaccaa acggaacgat agtgaaaaca atcacgaatg accaaattga     1440

agttactaat gctactgagc tggttcagaa ttcctcaata ggtgaaatat gcgacagtcc     1500

tcatcagatc cttgatggag aaaactgcac actaatagat gctctattgg gagaccctca     1560

gtgtgatggc ttccaaaata agaaatggga cctttttgtt gaacgaagca aagcctacag     1620

caactgttac ccttatgatg tgccggatta tgcctccctt aggtcactag ttgcctcatc     1680

cggcacactg gagtttaaca atgaaagctt caattggact ggagtcactc aaaacggaac     1740

aagttctgct tgcataagga gatctaataa tagtttcttt agtagattaa attggttgac     1800

ccacttaaac ttcaaatacc cagcattgaa cgtgactatg ccaaacaatg aacaatttga     1860

caaattgtac atttgggggg ttcaccaccc gggtacggac aaggaccaaa tcttcctgta     1920

tgctcaatca tcaggaagaa tcacagtatc taccaaaaga agccaacaag ctgtaatccc     1980

gaatatcgga tctagaccca gaataaggaa tatccctagc agaataagca tctattggac     2040

aatagtaaaa ccgggagaca tacttttgat taacagcaca gggaatctaa ttgctcctag     2100

gggttacttc aaaatacgaa gtgggaaaag ctcaataatg agatcagatg cacccattgg     2160

caaatgcaat tctgaatgca tcactccaaa tggaagcatt cccaatgaca aaccattcca     2220

aaatgtaaac aggatcacat acggggcctg tcccagatat gttaagcaaa gcactctgaa     2280

attggcaaca ggaatgcgaa atgtaccaga gaaacaaact agaggcatat ttggcgcaat     2340

agcgggtttc atagaaaatg gttgggaggg aatggtggat ggttggtacg gtttcaggca     2400

tcaaaattct gagggaagag gacaagcagc agatctcaaa agcactcaag cagcaatcga     2460

tcaaatcaat gggaagctga atcgattgat cgggaaaacc aacgagaaat tccatcagat     2520

tgaaaaagaa ttctcagaag tcgaagggag aattcaggac cttgagaaat atgttgagga     2580

cactaaaata gatctctggt catacaacgc ggagcttctt gttgccctgg agaaccaaca     2640

tacaattgat ctaactgact cagaaatgaa caaactgttt gaaaaaacaa agaagcaact     2700

aagggaaaat gctgaggata tgggcaatgg ttgtttcaaa atataccaca aatgtgacaa     2760

tgcctgcata ggatcaatca gaaatggaac ttatgaccac gatgtataca gagatgaagc     2820

attaaacaac cggttccaga tcaagggagt tgagctgaag tcagggtaca aagattggat     2880

cctatggatt tcctttgcca tatcatgttt tttgctttgt gttgctttgt tggggttcat     2940

catgtgggcc tgccaaaagg gcaacattag gtgcaacatt tgcatttgaa ggcctatttt     3000

ctttagtttg aatttactgt tattcggtgt gcatttctat gtttggtgag cggttttctg     3060

tgctcagagt gtgtttattt tatgtaattt aatttctttg tgagctcctg tttagcaggt     3120

cgtcccttca gcaaggacac aaaaagattt taattttatt aaaaaaaaaa aaaaaaaaga     3180

ccgggaattc gatatcaagc ttatcgacct gcagatcgtt caaacatttg gcaataaagt     3240

ttcttaagat tgaatcctgt tgccggtctt gcgatgatta tcatataatt tctgttgaat     3300

tacgttaagc atgtaataat taacatgtaa tgcatgacgt tatttatgag atgggttttt     3360

atgattagag tcccgcaatt atacatttaa tacgcgatag aaaacaaaat atagcgcgca     3420

aactaggata aattatcgcg cgcggtgtca tctatgttac tagat                     3465


<210>  23
<211>  574
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of PDISP/H3 Victoria

<400>  23

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Gln Lys Leu Pro Gly Asn Asp Asn 
            20                  25                  30          


Ser Thr Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr 
        35                  40                  45              


Ile Val Lys Thr Ile Thr Asn Asp Gln Ile Glu Val Thr Asn Ala Thr 
    50                  55                  60                  


Glu Leu Val Gln Asn Ser Ser Ile Gly Glu Ile Cys Asp Ser Pro His 
65                  70                  75                  80  


Gln Ile Leu Asp Gly Glu Asn Cys Thr Leu Ile Asp Ala Leu Leu Gly 
                85                  90                  95      


Asp Pro Gln Cys Asp Gly Phe Gln Asn Lys Lys Trp Asp Leu Phe Val 
            100                 105                 110         


Glu Arg Ser Lys Ala Tyr Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp 
        115                 120                 125             


Tyr Ala Ser Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe 
    130                 135                 140                 


Asn Asn Glu Ser Phe Asn Trp Thr Gly Val Thr Gln Asn Gly Thr Ser 
145                 150                 155                 160 


Ser Ala Cys Ile Arg Arg Ser Asn Asn Ser Phe Phe Ser Arg Leu Asn 
                165                 170                 175     


Trp Leu Thr His Leu Asn Phe Lys Tyr Pro Ala Leu Asn Val Thr Met 
            180                 185                 190         


Pro Asn Asn Glu Gln Phe Asp Lys Leu Tyr Ile Trp Gly Val His His 
        195                 200                 205             


Pro Gly Thr Asp Lys Asp Gln Ile Phe Leu Tyr Ala Gln Ser Ser Gly 
    210                 215                 220                 


Arg Ile Thr Val Ser Thr Lys Arg Ser Gln Gln Ala Val Ile Pro Asn 
225                 230                 235                 240 


Ile Gly Ser Arg Pro Arg Ile Arg Asn Ile Pro Ser Arg Ile Ser Ile 
                245                 250                 255     


Tyr Trp Thr Ile Val Lys Pro Gly Asp Ile Leu Leu Ile Asn Ser Thr 
            260                 265                 270         


Gly Asn Leu Ile Ala Pro Arg Gly Tyr Phe Lys Ile Arg Ser Gly Lys 
        275                 280                 285             


Ser Ser Ile Met Arg Ser Asp Ala Pro Ile Gly Lys Cys Asn Ser Glu 
    290                 295                 300                 


Cys Ile Thr Pro Asn Gly Ser Ile Pro Asn Asp Lys Pro Phe Gln Asn 
305                 310                 315                 320 


Val Asn Arg Ile Thr Tyr Gly Ala Cys Pro Arg Tyr Val Lys Gln Ser 
                325                 330                 335     


Thr Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Lys Gln Thr 
            340                 345                 350         


Arg Gly Ile Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
        355                 360                 365             


Gly Met Val Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ser Glu Gly 
    370                 375                 380                 


Arg Gly Gln Ala Ala Asp Leu Lys Ser Thr Gln Ala Ala Ile Asp Gln 
385                 390                 395                 400 


Ile Asn Gly Lys Leu Asn Arg Leu Ile Gly Lys Thr Asn Glu Lys Phe 
                405                 410                 415     


His Gln Ile Glu Lys Glu Phe Ser Glu Val Glu Gly Arg Ile Gln Asp 
            420                 425                 430         


Leu Glu Lys Tyr Val Glu Asp Thr Lys Ile Asp Leu Trp Ser Tyr Asn 
        435                 440                 445             


Ala Glu Leu Leu Val Ala Leu Glu Asn Gln His Thr Ile Asp Leu Thr 
    450                 455                 460                 


Asp Ser Glu Met Asn Lys Leu Phe Glu Lys Thr Lys Lys Gln Leu Arg 
465                 470                 475                 480 


Glu Asn Ala Glu Asp Met Gly Asn Gly Cys Phe Lys Ile Tyr His Lys 
                485                 490                 495     


Cys Asp Asn Ala Cys Ile Gly Ser Ile Arg Asn Gly Thr Tyr Asp His 
            500                 505                 510         


Asp Val Tyr Arg Asp Glu Ala Leu Asn Asn Arg Phe Gln Ile Lys Gly 
        515                 520                 525             


Val Glu Leu Lys Ser Gly Tyr Lys Asp Trp Ile Leu Trp Ile Ser Phe 
    530                 535                 540                 


Ala Ile Ser Cys Phe Leu Leu Cys Val Ala Leu Leu Gly Phe Ile Met 
545                 550                 555                 560 


Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 


<210>  24
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF(SacII)-Kozac_PDI.c

<400>  24
gtcgggccca ataccgcgga gaaaatggcg aaaaacgttg cgattttc                    48


<210>  25
<211>  4914
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of Construct 2181

<400>  25
tggcaggata tattgtggtg taaacaaatt gacgcttaga caacttaata acacattgcg       60

gacgttttta atgtactgaa ttaacgccga atcccgggct ggtatattta tatgttgtca      120

aataactcaa aaaccataaa agtttaagtt agcaagtgtg tacattttta cttgaacaaa      180

aatattcacc tactactgtt ataaatcatt attaaacatt agagtaaaga aatatggatg      240

ataagaacaa gagtagtgat attttgacaa caattttgtt gcaacatttg agaaaatttt      300

gttgttctct cttttcattg gtcaaaaaca atagagagag aaaaaggaag agggagaata      360

aaaacataat gtgagtatga gagagaaagt tgtacaaaag ttgtaccaaa atagttgtac      420

aaatatcatt gaggaatttg acaaaagcta cacaaataag ggttaattgc tgtaaataaa      480

taaggatgac gcattagaga gatgtaccat tagagaattt ttggcaagtc attaaaaaga      540

aagaataaat tatttttaaa attaaaagtt gagtcatttg attaaacatg tgattattta      600

atgaattgat gaaagagttg gattaaagtt gtattagtaa ttagaatttg gtgtcaaatt      660

taatttgaca tttgatcttt tcctatatat tgccccatag agtcagttaa ctcattttta      720

tatttcatag atcaaataag agaaataacg gtatattaat ccctccaaaa aaaaaaaacg      780

gtatatttac taaaaaatct aagccacgta ggaggataac aggatccccg taggaggata      840

acatccaatc caaccaatca caacaatcct gatgagataa cccactttaa gcccacgcat      900

ctgtggcaca tctacattat ctaaatcaca cattcttcca cacatctgag ccacacaaaa      960

accaatccac atctttatca cccattctat aaaaaatcac actttgtgag tctacacttt     1020

gattcccttc aaacacatac aaagagaaga gactaattaa ttaattaatc atcttgagag     1080

aaaatggaac gagctataca aggaaacgac gctagggaac aagctaacag tgaacgttgg     1140

gatggaggat caggaggtac cacttctccc ttcaaacttc ctgacgaaag tccgagttgg     1200

actgagtggc ggctacataa cgatgagacg aattcgaatc aagataatcc ccttggtttc     1260

aaggaaagct ggggtttcgg gaaagttgta tttaagagat atctcagata cgacaggacg     1320

gaagcttcac tgcacagagt ccttggatct tggacgggag attcggttaa ctatgcagca     1380

tctcgatttt tcggtttcga ccagatcgga tgtacctata gtattcggtt tcgaggagtt     1440

agtatcaccg tttctggagg gtcgcgaact cttcagcatc tctgtgagat ggcaattcgg     1500

tctaagcaag aactgctaca gcttgcccca atcgaagtgg aaagtaatgt atcaagagga     1560

tgccctgaag gtactcaaac cttcgaaaaa gaaagcgagt aagttaaaat gcttcttcgt     1620

ctcctattta taatatggtt tgttattgtt aattttgttc ttgtagaaga gcttaattaa     1680

tcgttgttgt tatgaaatac tatttgtatg agatgaactg gtgtaatgta attcatttac     1740

ataagtggag tcagaatcag aatgtttcct ccataactaa ctagacatga agacctgccg     1800

cgtacaattg tcttatattt gaacaactaa aattgaacat cttttgccac aactttataa     1860

gtggttaata tagctcaaat atatggtcaa gttcaataga ttaataatgg aaatatcagt     1920

tatcgaaatt cattaacaat caacttaacg ttattaacta ctaattttat atcatcccct     1980

ttgataaatg atagtacacc aattaggaag gagcatgctc gcctaggaga ttgtcgtttc     2040

ccgccttcag tttgcaagct gctctagccg tgtagccaat acgcaaaccg cctctccccg     2100

cgcgttggga attactagcg cgtgtcgaca agcttgcatg ccggtcaaca tggtggagca     2160

cgacacactt gtctactcca aaaatatcaa agatacagtc tcagaagacc aaagggcaat     2220

tgagactttt caacaaaggg taatatccgg aaacctcctc ggattccatt gcccagctat     2280

ctgtcacttt attgtgaaga tagtggaaaa ggaaggtggc tcctacaaat gccatcattg     2340

cgataaagga aaggccatcg ttgaagatgc ctctgccgac agtggtccca aagatggacc     2400

cccacccacg aggagcatcg tggaaaaaga agacgttcca accacgtctt caaagcaagt     2460

ggattgatgt gataacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga     2520

tacagtctca gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa     2580

cctcctcgga ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga     2640

aggtggctcc tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc     2700

tgccgacagt ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga     2760

cgttccaacc acgtcttcaa agcaagtgga ttgatgtgat atctccactg acgtaaggga     2820

tgacgcacaa tcccactatc cttcgcaaga cccttcctct atataaggaa gttcatttca     2880

tttggagagg tattaaaatc ttaataggtt ttgataaaag cgaacgtggg gaaacccgaa     2940

ccaaaccttc ttctaaactc tctctcatct ctcttaaagc aaacttctct cttgtctttc     3000

ttgcgtgagc gatcttcaac gttgtcagat cgtgcttcgg caccagtaca acgttttctt     3060

tcactgaagc gaaatcaaag atctctttgt ggacacgtag tgcggcgcca ttaaataacg     3120

tgtacttgtc ctattcttgt cggtgtggtc ttgggaaaag aaagcttgct ggaggctgct     3180

gttcagcccc atacattact tgttacgatt ctgctgactt tcggcgggtg caatatctct     3240

acttctgctt gacgaggtat tgttgcctgt acttctttct tcttcttctt gctgattggt     3300

tctataagaa atctagtatt ttctttgaaa cagagttttc ccgtggtttt cgaacttgga     3360

gaaagattgt taagcttctg tatattctgc ccaaatttgt cgggcccaat accgcggaga     3420

aaatggcgaa aaacgttgcg attttcggct tattgttttc tcttcttgtg ttggttcctt     3480

ctcagatctt cgcgacgtca ctcctcagcc aaaacgacac ccccatctgt ctatccactg     3540

gcccctggat ctgctgccca aactaactcc atggtgaccc tgggatgcct ggtcaagggc     3600

tatttccctg agccagtgac agtgacctgg aactctggat ccctgtccag cggtgtgcac     3660

accttcccag ctgtcctgca gtctgacctc tacactctga gcagctcagt gactgtcccc     3720

tccagcacct ggcccagcga gaccgtcacc tgcaacgttg cccacccggc cagcagcacc     3780

aaggtggaca agaaaattgt gcccagggat tgtggttgta agccttgcat atgtacagtc     3840

ccagaagtat catctgtctt catcttcccc ccaaagccca aggatgtgct caccattact     3900

ctgactccta aggtcacgtg tgttgtggta gacatcagca aggatgatcc cgaggtccag     3960

ttcagctggt ttgtagatga tgtggaggtg cacacagctc agacgcaacc ccgggaggag     4020

cagttcaaca gcactttccg ctcagtcagt gaacttccca tcatgcacca ggactggctc     4080

aatggcaagg agcgatcgct caccatcacc atcaccatca ccatcaccat taaaggccta     4140

ttttctttag tttgaattta ctgttattcg gtgtgcattt ctatgtttgg tgagcggttt     4200

tctgtgctca gagtgtgttt attttatgta atttaatttc tttgtgagct cctgtttagc     4260

aggtcgtccc ttcagcaagg acacaaaaag attttaattt tattaaaaaa aaaaaaaaaa     4320

aagaccggga attcgatatc aagcttatcg acctgcagat cgttcaaaca tttggcaata     4380

aagtttctta agattgaatc ctgttgccgg tcttgcgatg attatcatat aatttctgtt     4440

gaattacgtt aagcatgtaa taattaacat gtaatgcatg acgttattta tgagatgggt     4500

ttttatgatt agagtcccgc aattatacat ttaatacgcg atagaaaaca aaatatagcg     4560

cgcaaactag gataaattat cgcgcgcggt gtcatctatg ttactagatc tctagagtct     4620

caagcttggc gcgcccacgt gactagtggc actggccgtc gttttacaac gtcgtgactg     4680

ggaaaaccct ggcgttaccc aacttaatcg ccttgcagca catccccctt tcgccagctg     4740

gcgtaatagc gaagaggccc gcaccgatcg cccttcccaa cagttgcgca gcctgaatgg     4800

cgaatgctag agcagcttga gcttggatca gattgtcgtt tcccgccttc agtttaaact     4860

atcagtgttt gacaggatat attggcgggt aaacctaaga gaaaagagcg ttta           4914


<210>  26
<211>  3480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of expression cassette 1819

<400>  26
gtcaacatgg tggagcacga cacacttgtc tactccaaaa atatcaaaga tacagtctca       60

gaagaccaaa gggcaattga gacttttcaa caaagggtaa tatccggaaa cctcctcgga      120

ttccattgcc cagctatctg tcactttatt gtgaagatag tggaaaagga aggtggctcc      180

tacaaatgcc atcattgcga taaaggaaag gccatcgttg aagatgcctc tgccgacagt      240

ggtcccaaag atggaccccc acccacgagg agcatcgtgg aaaaagaaga cgttccaacc      300

acgtcttcaa agcaagtgga ttgatgtgat aacatggtgg agcacgacac acttgtctac      360

tccaaaaata tcaaagatac agtctcagaa gaccaaaggg caattgagac ttttcaacaa      420

agggtaatat ccggaaacct cctcggattc cattgcccag ctatctgtca ctttattgtg      480

aagatagtgg aaaaggaagg tggctcctac aaatgccatc attgcgataa aggaaaggcc      540

atcgttgaag atgcctctgc cgacagtggt cccaaagatg gacccccacc cacgaggagc      600

atcgtggaaa aagaagacgt tccaaccacg tcttcaaagc aagtggattg atgtgatatc      660

tccactgacg taagggatga cgcacaatcc cactatcctt cgcaagaccc ttcctctata      720

taaggaagtt catttcattt ggagaggtat taaaatctta ataggttttg ataaaagcga      780

acgtggggaa acccgaacca aaccttcttc taaactctct ctcatctctc ttaaagcaaa      840

cttctctctt gtctttcttg cgtgagcgat cttcaacgtt gtcagatcgt gcttcggcac      900

cagtacaacg ttttctttca ctgaagcgaa atcaaagatc tctttgtgga cacgtagtgc      960

ggcgccatta aataacgtgt acttgtccta ttcttgtcgg tgtggtcttg ggaaaagaaa     1020

gcttgctgga ggctgctgtt cagccccata cattacttgt tacgattctg ctgactttcg     1080

gcgggtgcaa tatctctact tctgcttgac gaggtattgt tgcctgtact tctttcttct     1140

tcttcttgct gattggttct ataagaaatc tagtattttc tttgaaacag agttttcccg     1200

tggttttcga acttggagaa agattgttaa gcttctgtat attctgccca aatttgtcgg     1260

gcccaatacc gcggagaaaa tggcgaaaaa cgttgcgatt ttcggcttat tgttttctct     1320

tcttgtgttg gttccttctc agatcttcgc ccaaaaactt cctggaaatg acaacagcac     1380

ggcaacgctg tgccttgggc accatgcagt accaaacgga acgatagtga aaacaatcac     1440

gaatgaccaa attgaagtta ctaatgctac tgagctggtt cagaattcct caataggtga     1500

aatatgcgac agtcctcatc agatccttga tggagaaaac tgcacactaa tagatgctct     1560

attgggagac cctcagtgtg atggcttcca aaataagaaa tgggaccttt ttgttgaacg     1620

aagcaaagcc tacagcaact gttaccctta tgatgtgccg gattatgcct cccttaggtc     1680

actagttgcc tcatccggca cactggagtt taacaatgaa agcttcaatt ggactggagt     1740

cactcaaaac ggaacaagtt ctgcttgcat aaggagatct aataatagtt tctttagtag     1800

attaaattgg ttgacccact taaacttcaa atacccagca ttgaacgtga ctatgccaaa     1860

caatgaacaa tttgacaaat tgtacatttg gggggttcac cacccgggta cggacaagga     1920

ccaaatcttc ctgtatgctc aatcatcagg aagaatcaca gtatctacca aaagaagcca     1980

acaagctgta atcccgaata tcggatctag acccagaata aggaatatcc ctagcagaat     2040

aagcatctat tggacaatag taaaaccggg agacatactt ttgattaaca gcacagggaa     2100

tctaattgct cctaggggtt acttcaaaat acgaagtggg aaaagctcaa taatgagatc     2160

agatgcaccc attggcaaat gcaattctga atgcatcact ccaaatggaa gcattcccaa     2220

tgacaaacca ttccaaaatg taaacaggat cacatacggg gcctgtccca gatatgttaa     2280

gcaaagcact ctgaaattgg caacaggaat gcgaaatgta ccagagaaac aaactagagg     2340

catatttggc gcaatagcgg gtttcataga aaatggttgg gagggaatgg tggatggttg     2400

gtacggtttc aggcatcaaa attctgaggg aagaggacaa gcagcagatc tcaaaagcac     2460

tcaagcagca atcgatcaaa tcaatgggaa gctgaatcga ttgatcggga aaaccaacga     2520

gaaattccat cagattgaaa aagaattctc agaagtcgaa gggagaattc aggaccttga     2580

gaaatatgtt gaggacacta aaatagatct ctggtcatac aacgcggagc ttcttgttgc     2640

cctggagaac caacatacaa ttgatctaac tgactcagaa atgaacaaac tgtttgaaaa     2700

aacaaagaag caactaaggg aaaatgctga ggatatgggc aatggttgtt tcaaaatata     2760

ccacaaatgt gacaatgcct gcataggatc aatcagaaat ggaacttatg accacgatgt     2820

atacagagat gaagcattaa acaaccggtt ccagatcaag ggagttgagc tgaagtcagg     2880

gtacaaagat tggatcctat ggatttcctt tgccatatca tgttttttgc tttgtgttgc     2940

tttgttgggg ttcatcatgt gggcctgcca aaagggcaac attaggtgca acatttgcat     3000

ttgaaggcct attttcttta gtttgaattt actgttattc ggtgtgcatt tctatgtttg     3060

gtgagcggtt ttctgtgctc agagtgtgtt tattttatgt aatttaattt ctttgtgagc     3120

tcctgtttag caggtcgtcc cttcagcaag gacacaaaaa gattttaatt ttattaaaaa     3180

aaaaaaaaaa aaagaccggg aattcgatat caagcttatc gacctgcaga tcgttcaaac     3240

atttggcaat aaagtttctt aagattgaat cctgttgccg gtcttgcgat gattatcata     3300

taatttctgt tgaattacgt taagcatgta ataattaaca tgtaatgcat gacgttattt     3360

atgagatggg tttttatgat tagagtcccg caattataca tttaatacgc gatagaaaac     3420

aaaatatagc gcgcaaacta ggataaatta tcgcgcgcgg tgtcatctat gttactagat     3480


<210>  27
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer IF-HT1*-PDI.c

<400>  27
gtcgggccca ataccgcgga gacaatggcg aaaaacgttg cgattttcgg ct               52


<210>  28
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer IF-HT2*-PDI.c

<400>  28
gtcgggccca ataccgcgga ggaaatggcg aaaaacgttg cgattttcgg ct               52


<210>  29
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer IF-HT3*-PDI.c

<400>  29
gtcgggccca ataccgcgga aaaaatggcg aaaaacgttg cgattttcgg ct               52


<210>  30
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer IF-HT4*-PDI.c

<400>  30
gtcgggccca ataccgcgga aacaatggcg aaaaacgttg cgattttcgg ct               52


<210>  31
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer IF-HT5*-PDI.c

<400>  31
gtcgggccca ataccgcgga agcaatggcg aaaaacgttg cgattttcgg ct               52


<210>  32
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer IF-HT6*-PDI.c

<400>  32
gtcgggccca ataccgcgga agaaatggcg aaaaacgttg cgattttcgg ct               52


<210>  33
<211>  53
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF-HT7*-PDI.c

<400>  33
gtcgggccca ataccgcgga aagaaatggc gaaaaacgtt gcgattttcg gct              53


<210>  34
<211>  54
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IF-HT8*-PDI.c

<400>  34
gtcgggccca ataccgcgga aaagaaatgg cgaaaaacgt tgcgattttc ggct             54


<210>  35
<211>  1722
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of PDISP/H1 California

<400>  35
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg ctgacacatt atgtataggt tatcatgcga acaattcaac agacactgta      120

gacacagtac tagaaaagaa tgtaacagta acacactctg ttaaccttct agaagacaag      180

cataacggga aactatgcaa actaagaggg gtagccccat tgcatttggg taaatgtaac      240

attgctggct ggatcctggg aaatccagag tgtgaatcac tctccacagc aagctcatgg      300

tcctacattg tggaaacacc tagttcagac aatggaacgt gttacccagg agatttcatc      360

gattatgagg agctaagaga gcaattgagc tcagtgtcat catttgaaag gtttgagata      420

ttccccaaga caagttcatg gcccaatcat gactcgaaca aaggtgtaac ggcagcatgt      480

cctcatgctg gagcaaaaag cttctacaaa aatttaatat ggctagttaa aaaaggaaat      540

tcatacccaa agctcagcaa atcctacatt aatgataaag ggaaagaagt cctcgtgcta      600

tggggcattc accatccatc tactagtgct gaccaacaaa gtctctatca gaatgcagat      660

gcatatgttt ttgtggggtc atcaagatac agcaagaagt tcaagccgga aatagcaata      720

agacccaaag tgagggatca agaagggaga atgaactatt actggacact agtagagccg      780

ggagacaaaa taacattcga agcaactgga aatctagtgg taccgagata tgcattcgca      840

atggaaagaa atgctggatc tggtattatc atttcagata caccagtcca cgattgcaat      900

acaacttgtc aaacacccaa gggtgctata aacaccagcc tcccatttca gaatatacat      960

ccgatcacaa ttggaaaatg tccaaaatat gtaaaaagca caaaattgag actggccaca     1020

ggattgagga atatcccgtc tattcaatct agaggactat ttggggccat tgccggtttc     1080

attgaagggg ggtggacagg gatggtagat ggatggtacg gttatcacca tcaaaatgag     1140

caggggtcag gatatgcagc cgacctgaag agcacacaga atgccattga cgagattact     1200

aacaaagtaa attctgttat tgaaaagatg aatacacagt tcacagcagt aggtaaagag     1260

ttcaaccacc tggaaaaaag aatagagaat ttaaataaaa aagttgatga tggtttcctg     1320

gacatttgga cttacaatgc cgaactgttg gttctattgg aaaatgaaag aactttggac     1380

taccacgatt caaatgtgaa gaacttatat gaaaaggtaa gaagccagct aaaaaacaat     1440

gccaaggaaa ttggaaacgg ctgctttgaa ttttaccaca aatgcgataa cacgtgcatg     1500

gaaagtgtca aaaatgggac ttatgactac ccaaaatact cagaggaagc aaaattaaac     1560

agagaagaaa tagatggggt aaagctggaa tcaacaagga tttaccagat tttggcgatc     1620

tattcaactg tcgccagttc attggtactg gtagtctccc tgggggcaat cagtttctgg     1680

atgtgctcta atgggtctct acagtgtaga atatgtattt aa                        1722


<210>  36
<211>  573
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of PDISP/H1 California

<400>  36

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Asp Thr Leu Cys Ile Gly Tyr His 
            20                  25                  30          


Ala Asn Asn Ser Thr Asp Thr Val Asp Thr Val Leu Glu Lys Asn Val 
        35                  40                  45              


Thr Val Thr His Ser Val Asn Leu Leu Glu Asp Lys His Asn Gly Lys 
    50                  55                  60                  


Leu Cys Lys Leu Arg Gly Val Ala Pro Leu His Leu Gly Lys Cys Asn 
65                  70                  75                  80  


Ile Ala Gly Trp Ile Leu Gly Asn Pro Glu Cys Glu Ser Leu Ser Thr 
                85                  90                  95      


Ala Ser Ser Trp Ser Tyr Ile Val Glu Thr Pro Ser Ser Asp Asn Gly 
            100                 105                 110         


Thr Cys Tyr Pro Gly Asp Phe Ile Asp Tyr Glu Glu Leu Arg Glu Gln 
        115                 120                 125             


Leu Ser Ser Val Ser Ser Phe Glu Arg Phe Glu Ile Phe Pro Lys Thr 
    130                 135                 140                 


Ser Ser Trp Pro Asn His Asp Ser Asn Lys Gly Val Thr Ala Ala Cys 
145                 150                 155                 160 


Pro His Ala Gly Ala Lys Ser Phe Tyr Lys Asn Leu Ile Trp Leu Val 
                165                 170                 175     


Lys Lys Gly Asn Ser Tyr Pro Lys Leu Ser Lys Ser Tyr Ile Asn Asp 
            180                 185                 190         


Lys Gly Lys Glu Val Leu Val Leu Trp Gly Ile His His Pro Ser Thr 
        195                 200                 205             


Ser Ala Asp Gln Gln Ser Leu Tyr Gln Asn Ala Asp Ala Tyr Val Phe 
    210                 215                 220                 


Val Gly Ser Ser Arg Tyr Ser Lys Lys Phe Lys Pro Glu Ile Ala Ile 
225                 230                 235                 240 


Arg Pro Lys Val Arg Asp Gln Glu Gly Arg Met Asn Tyr Tyr Trp Thr 
                245                 250                 255     


Leu Val Glu Pro Gly Asp Lys Ile Thr Phe Glu Ala Thr Gly Asn Leu 
            260                 265                 270         


Val Val Pro Arg Tyr Ala Phe Ala Met Glu Arg Asn Ala Gly Ser Gly 
        275                 280                 285             


Ile Ile Ile Ser Asp Thr Pro Val His Asp Cys Asn Thr Thr Cys Gln 
    290                 295                 300                 


Thr Pro Lys Gly Ala Ile Asn Thr Ser Leu Pro Phe Gln Asn Ile His 
305                 310                 315                 320 


Pro Ile Thr Ile Gly Lys Cys Pro Lys Tyr Val Lys Ser Thr Lys Leu 
                325                 330                 335     


Arg Leu Ala Thr Gly Leu Arg Asn Ile Pro Ser Ile Gln Ser Arg Gly 
            340                 345                 350         


Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp Thr Gly Met 
        355                 360                 365             


Val Asp Gly Trp Tyr Gly Tyr His His Gln Asn Glu Gln Gly Ser Gly 
    370                 375                 380                 


Tyr Ala Ala Asp Leu Lys Ser Thr Gln Asn Ala Ile Asp Glu Ile Thr 
385                 390                 395                 400 


Asn Lys Val Asn Ser Val Ile Glu Lys Met Asn Thr Gln Phe Thr Ala 
                405                 410                 415     


Val Gly Lys Glu Phe Asn His Leu Glu Lys Arg Ile Glu Asn Leu Asn 
            420                 425                 430         


Lys Lys Val Asp Asp Gly Phe Leu Asp Ile Trp Thr Tyr Asn Ala Glu 
        435                 440                 445             


Leu Leu Val Leu Leu Glu Asn Glu Arg Thr Leu Asp Tyr His Asp Ser 
    450                 455                 460                 


Asn Val Lys Asn Leu Tyr Glu Lys Val Arg Ser Gln Leu Lys Asn Asn 
465                 470                 475                 480 


Ala Lys Glu Ile Gly Asn Gly Cys Phe Glu Phe Tyr His Lys Cys Asp 
                485                 490                 495     


Asn Thr Cys Met Glu Ser Val Lys Asn Gly Thr Tyr Asp Tyr Pro Lys 
            500                 505                 510         


Tyr Ser Glu Glu Ala Lys Leu Asn Arg Glu Glu Ile Asp Gly Val Lys 
        515                 520                 525             


Leu Glu Ser Thr Arg Ile Tyr Gln Ile Leu Ala Ile Tyr Ser Thr Val 
    530                 535                 540                 


Ala Ser Ser Leu Val Leu Val Val Ser Leu Gly Ala Ile Ser Phe Trp 
545                 550                 555                 560 


Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
                565                 570             


<210>  37
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of PDISP/H5 Indonesia

<400>  37
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg ccgatcagat ttgcattggt taccatgcaa acaattcaac agagcaggtt      120

gacacaatca tggaaaagaa cgttactgtt acacatgccc aagacatact ggaaaagaca      180

cacaacggga agctctgcga tctagatgga gtgaagcctc taattttaag agattgtagt      240

gtagctggat ggctcctcgg gaacccaatg tgtgacgaat tcatcaatgt accggaatgg      300

tcttacatag tggagaaggc caatccaacc aatgacctct gttacccagg gagtttcaac      360

gactatgaag aactgaaaca cctattgagc agaataaacc attttgagaa aattcaaatc      420

atccccaaaa gttcttggtc cgatcatgaa gcctcatcag gagttagctc agcatgtcca      480

tacctgggaa gtccctcctt ttttagaaat gtggtatggc ttatcaaaaa gaacagtaca      540

tacccaacaa taaagaaaag ctacaataat accaaccaag aggatctttt ggtactgtgg      600

ggaattcacc atcctaatga tgcggcagag cagacaaggc tatatcaaaa cccaaccacc      660

tatatttcca ttgggacatc aacactaaac cagagattgg taccaaaaat agctactaga      720

tccaaagtaa acgggcaaag tggaaggatg gagttcttct ggacaatttt aaaacctaat      780

gatgcaatca acttcgagag taatggaaat ttcattgctc cagaatatgc atacaaaatt      840

gtcaagaaag gggactcagc aattatgaaa agtgaattgg aatatggtaa ctgcaacacc      900

aagtgtcaaa ctccaatggg ggcgataaac tctagtatgc cattccacaa catacaccct      960

ctcaccatcg gggaatgccc caaatatgtg aaatcaaaca gattagtcct tgcaacaggg     1020

ctcagaaata gccctcaaag agagagcaga agaaaaaaga gaggactatt tggagctata     1080

gcaggtttta tagagggagg atggcaggga atggtagatg gttggtatgg gtaccaccat     1140

agcaatgagc aggggagtgg gtacgctgca gacaaagaat ccactcaaaa ggcaatagat     1200

ggagtcacca ataaggtcaa ctcaatcatt gacaaaatga acactcagtt tgaggccgtt     1260

ggaagggaat ttaataactt agaaaggaga atagagaatt taaacaagaa gatggaagac     1320

gggtttctag atgtctggac ttataatgcc gaacttctgg ttctcatgga aaatgagaga     1380

actctagact ttcatgactc aaatgttaag aacctctacg acaaggtccg actacagctt     1440

agggataatg caaaggagct gggtaacggt tgtttcgagt tctatcacaa atgtgataat     1500

gaatgtatgg aaagtataag aaacggaacg tacaactatc cgcagtattc agaagaagca     1560

agattaaaaa gagaggaaat aagtggggta aaattggaat caataggaac ttaccaaata     1620

ctgtcaattt attcaacagt ggcgagttcc ctagcactgg caatcatgat ggctggtcta     1680

tctttatgga tgtgctccaa tggatcgtta caatgcagaa tttgcatt                  1728


<210>  38
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of PDISP/H5 Indonesia

<400>  38

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Asp Gln Ile Cys Ile Gly Tyr His 
            20                  25                  30          


Ala Asn Asn Ser Thr Glu Gln Val Asp Thr Ile Met Glu Lys Asn Val 
        35                  40                  45              


Thr Val Thr His Ala Gln Asp Ile Leu Glu Lys Thr His Asn Gly Lys 
    50                  55                  60                  


Leu Cys Asp Leu Asp Gly Val Lys Pro Leu Ile Leu Arg Asp Cys Ser 
65                  70                  75                  80  


Val Ala Gly Trp Leu Leu Gly Asn Pro Met Cys Asp Glu Phe Ile Asn 
                85                  90                  95      


Val Pro Glu Trp Ser Tyr Ile Val Glu Lys Ala Asn Pro Thr Asn Asp 
            100                 105                 110         


Leu Cys Tyr Pro Gly Ser Phe Asn Asp Tyr Glu Glu Leu Lys His Leu 
        115                 120                 125             


Leu Ser Arg Ile Asn His Phe Glu Lys Ile Gln Ile Ile Pro Lys Ser 
    130                 135                 140                 


Ser Trp Ser Asp His Glu Ala Ser Ser Gly Val Ser Ser Ala Cys Pro 
145                 150                 155                 160 


Tyr Leu Gly Ser Pro Ser Phe Phe Arg Asn Val Val Trp Leu Ile Lys 
                165                 170                 175     


Lys Asn Ser Thr Tyr Pro Thr Ile Lys Lys Ser Tyr Asn Asn Thr Asn 
            180                 185                 190         


Gln Glu Asp Leu Leu Val Leu Trp Gly Ile His His Pro Asn Asp Ala 
        195                 200                 205             


Ala Glu Gln Thr Arg Leu Tyr Gln Asn Pro Thr Thr Tyr Ile Ser Ile 
    210                 215                 220                 


Gly Thr Ser Thr Leu Asn Gln Arg Leu Val Pro Lys Ile Ala Thr Arg 
225                 230                 235                 240 


Ser Lys Val Asn Gly Gln Ser Gly Arg Met Glu Phe Phe Trp Thr Ile 
                245                 250                 255     


Leu Lys Pro Asn Asp Ala Ile Asn Phe Glu Ser Asn Gly Asn Phe Ile 
            260                 265                 270         


Ala Pro Glu Tyr Ala Tyr Lys Ile Val Lys Lys Gly Asp Ser Ala Ile 
        275                 280                 285             


Met Lys Ser Glu Leu Glu Tyr Gly Asn Cys Asn Thr Lys Cys Gln Thr 
    290                 295                 300                 


Pro Met Gly Ala Ile Asn Ser Ser Met Pro Phe His Asn Ile His Pro 
305                 310                 315                 320 


Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys Ser Asn Arg Leu Val 
                325                 330                 335     


Leu Ala Thr Gly Leu Arg Asn Ser Pro Gln Arg Glu Ser Arg Arg Lys 
            340                 345                 350         


Lys Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Gly Gly Trp 
        355                 360                 365             


Gln Gly Met Val Asp Gly Trp Tyr Gly Tyr His His Ser Asn Glu Gln 
    370                 375                 380                 


Gly Ser Gly Tyr Ala Ala Asp Lys Glu Ser Thr Gln Lys Ala Ile Asp 
385                 390                 395                 400 


Gly Val Thr Asn Lys Val Asn Ser Ile Ile Asp Lys Met Asn Thr Gln 
                405                 410                 415     


Phe Glu Ala Val Gly Arg Glu Phe Asn Asn Leu Glu Arg Arg Ile Glu 
            420                 425                 430         


Asn Leu Asn Lys Lys Met Glu Asp Gly Phe Leu Asp Val Trp Thr Tyr 
        435                 440                 445             


Asn Ala Glu Leu Leu Val Leu Met Glu Asn Glu Arg Thr Leu Asp Phe 
    450                 455                 460                 


His Asp Ser Asn Val Lys Asn Leu Tyr Asp Lys Val Arg Leu Gln Leu 
465                 470                 475                 480 


Arg Asp Asn Ala Lys Glu Leu Gly Asn Gly Cys Phe Glu Phe Tyr His 
                485                 490                 495     


Lys Cys Asp Asn Glu Cys Met Glu Ser Ile Arg Asn Gly Thr Tyr Asn 
            500                 505                 510         


Tyr Pro Gln Tyr Ser Glu Glu Ala Arg Leu Lys Arg Glu Glu Ile Ser 
        515                 520                 525             


Gly Val Lys Leu Glu Ser Ile Gly Thr Tyr Gln Ile Leu Ser Ile Tyr 
    530                 535                 540                 


Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met Met Ala Gly Leu 
545                 550                 555                 560 


Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
                565                 570                 575     


<210>  39
<211>  1701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of PDISP/H7 Hangzhou

<400>  39
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggacaaaat ctgcctcgga catcatgccg tgtcaaacgg aaccaaagta      120

aacacattaa ctgaaagagg agtggaagtc gtcaatgcaa ctgaaacagt ggaacgaaca      180

aacatcccca ggatctgctc aaaagggaaa aggacagttg acctcggtca atgtggactc      240

ctggggacaa tcactggacc acctcaatgt gaccaattcc tagaattttc agccgattta      300

attattgaga ggcgagaagg aagtgatgtc tgttatcctg ggaaattcgt gaatgaagaa      360

gctctgaggc aaattctcag agaatcaggc ggaattgaca aggaagcaat gggattcaca      420

tacagtggaa taagaactaa tggagcaacc agtgcatgta ggagatcagg atcttcattc      480

tatgcagaaa tgaaatggct cctgtcaaac acagataatg ctgcattccc gcagatgact      540

aagtcatata aaaatacaag aaaaagccca gctctaatag tatgggggat ccatcattcc      600

gtatcaactg cagagcaaac caagctatat gggagtggaa acaaactggt gacagttggg      660

agttctaatt atcaacaatc ttttgtaccg agtccaggag cgagaccaca agttaatggt      720

atatctggaa gaattgactt tcattggcta atgctaaatc ccaatgatac agtcactttc      780

agtttcaatg gggctttcat agctccagac cgtgcaagct tcctgagagg aaaatctatg      840

ggaatccaga gtggagtaca ggttgatgcc aattgtgaag gggactgcta tcatagtgga      900

gggacaataa taagtaactt gccatttcag aacatagata gcagggcagt tggaaaatgt      960

ccgagatatg ttaagcaaag gagtctgctg ctagcaacag ggatgaagaa tgttcctgag     1020

attccaaagg gaagaggcct atttggtgct atagcgggtt tcattgaaaa tggatgggaa     1080

ggcctaattg atggttggta tggtttcaga caccagaatg cacagggaga gggaactgct     1140

gcagattaca aaagcactca atcggcaatt gatcaaataa caggaaaatt aaaccggctt     1200

atagaaaaaa ccaaccaaca atttgagttg atcgacaatg aattcaatga ggtagagaag     1260

caaatcggta atgtgataaa ttggaccaga gattctataa cagaagtgtg gtcatacaat     1320

gctgaactct tggtagcaat ggagaaccag catacaattg atctggctga ttcagaaatg     1380

gacaaactgt acgaacgagt gaaaagacag ctgagagaga atgctgaaga agatggcact     1440

ggttgctttg aaatatttca caagtgtgat gatgactgta tggccagtat tagaaataac     1500

acctatgatc acagcaaata cagggaagag gcaatgcaaa atagaataca gattgaccca     1560

gtcaaactaa gcagcggcta caaagatgtg atactttggt ttagcttcgg ggcatcatgt     1620

ttcatacttc tagccattgt aatgggcctt gtcttcatat gtgtaaagaa tggaaacatg     1680

cggtgcacta tttgtatata a                                               1701


<210>  40
<211>  566
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of PDISP/H7 Hangzhou

<400>  40

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Asp Lys Ile Cys Leu Gly His His 
            20                  25                  30          


Ala Val Ser Asn Gly Thr Lys Val Asn Thr Leu Thr Glu Arg Gly Val 
        35                  40                  45              


Glu Val Val Asn Ala Thr Glu Thr Val Glu Arg Thr Asn Ile Pro Arg 
    50                  55                  60                  


Ile Cys Ser Lys Gly Lys Arg Thr Val Asp Leu Gly Gln Cys Gly Leu 
65                  70                  75                  80  


Leu Gly Thr Ile Thr Gly Pro Pro Gln Cys Asp Gln Phe Leu Glu Phe 
                85                  90                  95      


Ser Ala Asp Leu Ile Ile Glu Arg Arg Glu Gly Ser Asp Val Cys Tyr 
            100                 105                 110         


Pro Gly Lys Phe Val Asn Glu Glu Ala Leu Arg Gln Ile Leu Arg Glu 
        115                 120                 125             


Ser Gly Gly Ile Asp Lys Glu Ala Met Gly Phe Thr Tyr Ser Gly Ile 
    130                 135                 140                 


Arg Thr Asn Gly Ala Thr Ser Ala Cys Arg Arg Ser Gly Ser Ser Phe 
145                 150                 155                 160 


Tyr Ala Glu Met Lys Trp Leu Leu Ser Asn Thr Asp Asn Ala Ala Phe 
                165                 170                 175     


Pro Gln Met Thr Lys Ser Tyr Lys Asn Thr Arg Lys Ser Pro Ala Leu 
            180                 185                 190         


Ile Val Trp Gly Ile His His Ser Val Ser Thr Ala Glu Gln Thr Lys 
        195                 200                 205             


Leu Tyr Gly Ser Gly Asn Lys Leu Val Thr Val Gly Ser Ser Asn Tyr 
    210                 215                 220                 


Gln Gln Ser Phe Val Pro Ser Pro Gly Ala Arg Pro Gln Val Asn Gly 
225                 230                 235                 240 


Ile Ser Gly Arg Ile Asp Phe His Trp Leu Met Leu Asn Pro Asn Asp 
                245                 250                 255     


Thr Val Thr Phe Ser Phe Asn Gly Ala Phe Ile Ala Pro Asp Arg Ala 
            260                 265                 270         


Ser Phe Leu Arg Gly Lys Ser Met Gly Ile Gln Ser Gly Val Gln Val 
        275                 280                 285             


Asp Ala Asn Cys Glu Gly Asp Cys Tyr His Ser Gly Gly Thr Ile Ile 
    290                 295                 300                 


Ser Asn Leu Pro Phe Gln Asn Ile Asp Ser Arg Ala Val Gly Lys Cys 
305                 310                 315                 320 


Pro Arg Tyr Val Lys Gln Arg Ser Leu Leu Leu Ala Thr Gly Met Lys 
                325                 330                 335     


Asn Val Pro Glu Ile Pro Lys Gly Arg Gly Leu Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Leu Ile Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ala Gln Gly Glu Gly Thr Ala Ala Asp Tyr Lys 
    370                 375                 380                 


Ser Thr Gln Ser Ala Ile Asp Gln Ile Thr Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Gln Gln Phe Glu Leu Ile Asp Asn Glu Phe Asn 
                405                 410                 415     


Glu Val Glu Lys Gln Ile Gly Asn Val Ile Asn Trp Thr Arg Asp Ser 
            420                 425                 430         


Ile Thr Glu Val Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Met Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Ala Asp Ser Glu Met Asp Lys Leu Tyr 
    450                 455                 460                 


Glu Arg Val Lys Arg Gln Leu Arg Glu Asn Ala Glu Glu Asp Gly Thr 
465                 470                 475                 480 


Gly Cys Phe Glu Ile Phe His Lys Cys Asp Asp Asp Cys Met Ala Ser 
                485                 490                 495     


Ile Arg Asn Asn Thr Tyr Asp His Ser Lys Tyr Arg Glu Glu Ala Met 
            500                 505                 510         


Gln Asn Arg Ile Gln Ile Asp Pro Val Lys Leu Ser Ser Gly Tyr Lys 
        515                 520                 525             


Asp Val Ile Leu Trp Phe Ser Phe Gly Ala Ser Cys Phe Ile Leu Leu 
    530                 535                 540                 


Ala Ile Val Met Gly Leu Val Phe Ile Cys Val Lys Asn Gly Asn Met 
545                 550                 555                 560 


Arg Cys Thr Ile Cys Ile 
                565     


<210>  41
<211>  1698
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of PDISP/H7 Hangzhou+H5 Indonesia TMCT

<400>  41
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg cggacaaaat ctgcctcgga catcatgccg tgtcaaacgg aaccaaagta      120

aacacattaa ctgaaagagg agtggaagtc gtcaatgcaa ctgaaacagt ggaacgaaca      180

aacatcccca ggatctgctc aaaagggaaa aggacagttg acctcggtca atgtggactc      240

ctggggacaa tcactggacc acctcaatgt gaccaattcc tagaattttc agccgattta      300

attattgaga ggcgagaagg aagtgatgtc tgttatcctg ggaaattcgt gaatgaagaa      360

gctctgaggc aaattctcag agaatcaggc ggaattgaca aggaagcaat gggattcaca      420

tacagtggaa taagaactaa tggagcaacc agtgcatgta ggagatcagg atcttcattc      480

tatgcagaaa tgaaatggct cctgtcaaac acagataatg ctgcattccc gcagatgact      540

aagtcatata aaaatacaag aaaaagccca gctctaatag tatgggggat ccatcattcc      600

gtatcaactg cagagcaaac caagctatat gggagtggaa acaaactggt gacagttggg      660

agttctaatt atcaacaatc ttttgtaccg agtccaggag cgagaccaca agttaatggt      720

atatctggaa gaattgactt tcattggcta atgctaaatc ccaatgatac agtcactttc      780

agtttcaatg gggctttcat agctccagac cgtgcaagct tcctgagagg aaaatctatg      840

ggaatccaga gtggagtaca ggttgatgcc aattgtgaag gggactgcta tcatagtgga      900

gggacaataa taagtaactt gccatttcag aacatagata gcagggcagt tggaaaatgt      960

ccgagatatg ttaagcaaag gagtctgctg ctagcaacag ggatgaagaa tgttcctgag     1020

attccaaagg gaagaggcct atttggtgct atagcgggtt tcattgaaaa tggatgggaa     1080

ggcctaattg atggttggta tggtttcaga caccagaatg cacagggaga gggaactgct     1140

gcagattaca aaagcactca atcggcaatt gatcaaataa caggaaaatt aaaccggctt     1200

atagaaaaaa ccaaccaaca atttgagttg atcgacaatg aattcaatga ggtagagaag     1260

caaatcggta atgtgataaa ttggaccaga gattctataa cagaagtgtg gtcatacaat     1320

gctgaactct tggtagcaat ggagaaccag catacaattg atctggctga ttcagaaatg     1380

gacaaactgt acgaacgagt gaaaagacag ctgagagaga atgctgaaga agatggcact     1440

ggttgctttg aaatatttca caagtgtgat gatgactgta tggccagtat tagaaataac     1500

acctatgatc acagcaaata cagggaagag gcaatgcaaa atagaataca gattgaccca     1560

gtcaaactaa gcagcggcta ccaaatactg tcaatttatt caacagtggc gagttcccta     1620

gcactggcaa tcatgatggc tggtctatct ttatggatgt gctccaatgg atcgttacaa     1680

tgcagaattt gcatttaa                                                   1698


<210>  42
<211>  565
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of PDISP/H7 Hangzhou+H5 Indonesia TMCT

<400>  42

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Asp Lys Ile Cys Leu Gly His His 
            20                  25                  30          


Ala Val Ser Asn Gly Thr Lys Val Asn Thr Leu Thr Glu Arg Gly Val 
        35                  40                  45              


Glu Val Val Asn Ala Thr Glu Thr Val Glu Arg Thr Asn Ile Pro Arg 
    50                  55                  60                  


Ile Cys Ser Lys Gly Lys Arg Thr Val Asp Leu Gly Gln Cys Gly Leu 
65                  70                  75                  80  


Leu Gly Thr Ile Thr Gly Pro Pro Gln Cys Asp Gln Phe Leu Glu Phe 
                85                  90                  95      


Ser Ala Asp Leu Ile Ile Glu Arg Arg Glu Gly Ser Asp Val Cys Tyr 
            100                 105                 110         


Pro Gly Lys Phe Val Asn Glu Glu Ala Leu Arg Gln Ile Leu Arg Glu 
        115                 120                 125             


Ser Gly Gly Ile Asp Lys Glu Ala Met Gly Phe Thr Tyr Ser Gly Ile 
    130                 135                 140                 


Arg Thr Asn Gly Ala Thr Ser Ala Cys Arg Arg Ser Gly Ser Ser Phe 
145                 150                 155                 160 


Tyr Ala Glu Met Lys Trp Leu Leu Ser Asn Thr Asp Asn Ala Ala Phe 
                165                 170                 175     


Pro Gln Met Thr Lys Ser Tyr Lys Asn Thr Arg Lys Ser Pro Ala Leu 
            180                 185                 190         


Ile Val Trp Gly Ile His His Ser Val Ser Thr Ala Glu Gln Thr Lys 
        195                 200                 205             


Leu Tyr Gly Ser Gly Asn Lys Leu Val Thr Val Gly Ser Ser Asn Tyr 
    210                 215                 220                 


Gln Gln Ser Phe Val Pro Ser Pro Gly Ala Arg Pro Gln Val Asn Gly 
225                 230                 235                 240 


Ile Ser Gly Arg Ile Asp Phe His Trp Leu Met Leu Asn Pro Asn Asp 
                245                 250                 255     


Thr Val Thr Phe Ser Phe Asn Gly Ala Phe Ile Ala Pro Asp Arg Ala 
            260                 265                 270         


Ser Phe Leu Arg Gly Lys Ser Met Gly Ile Gln Ser Gly Val Gln Val 
        275                 280                 285             


Asp Ala Asn Cys Glu Gly Asp Cys Tyr His Ser Gly Gly Thr Ile Ile 
    290                 295                 300                 


Ser Asn Leu Pro Phe Gln Asn Ile Asp Ser Arg Ala Val Gly Lys Cys 
305                 310                 315                 320 


Pro Arg Tyr Val Lys Gln Arg Ser Leu Leu Leu Ala Thr Gly Met Lys 
                325                 330                 335     


Asn Val Pro Glu Ile Pro Lys Gly Arg Gly Leu Phe Gly Ala Ile Ala 
            340                 345                 350         


Gly Phe Ile Glu Asn Gly Trp Glu Gly Leu Ile Asp Gly Trp Tyr Gly 
        355                 360                 365             


Phe Arg His Gln Asn Ala Gln Gly Glu Gly Thr Ala Ala Asp Tyr Lys 
    370                 375                 380                 


Ser Thr Gln Ser Ala Ile Asp Gln Ile Thr Gly Lys Leu Asn Arg Leu 
385                 390                 395                 400 


Ile Glu Lys Thr Asn Gln Gln Phe Glu Leu Ile Asp Asn Glu Phe Asn 
                405                 410                 415     


Glu Val Glu Lys Gln Ile Gly Asn Val Ile Asn Trp Thr Arg Asp Ser 
            420                 425                 430         


Ile Thr Glu Val Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Met Glu 
        435                 440                 445             


Asn Gln His Thr Ile Asp Leu Ala Asp Ser Glu Met Asp Lys Leu Tyr 
    450                 455                 460                 


Glu Arg Val Lys Arg Gln Leu Arg Glu Asn Ala Glu Glu Asp Gly Thr 
465                 470                 475                 480 


Gly Cys Phe Glu Ile Phe His Lys Cys Asp Asp Asp Cys Met Ala Ser 
                485                 490                 495     


Ile Arg Asn Asn Thr Tyr Asp His Ser Lys Tyr Arg Glu Glu Ala Met 
            500                 505                 510         


Gln Asn Arg Ile Gln Ile Asp Pro Val Lys Leu Ser Ser Gly Tyr Gln 
        515                 520                 525             


Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala Ile 
    530                 535                 540                 


Met Met Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly Ser Leu Gln 
545                 550                 555                 560 


Cys Arg Ile Cys Ile 
                565 


<210>  43
<211>  1734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of PDISP/HA B Brisbane (PrL-).

<400>  43
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg ccgatcgaat ctgcactgga ataacatcgt caaactcacc acatgtcgtc      120

aaaactgcta ctcaagggga ggtcaatgtg actggtgtaa taccactgac aacaacaccc      180

accaaatctc attttgcaaa tctcaaagga acagaaacca gggggaaact atgcccaaaa      240

tgcctcaact gcacagatct ggacgtagcc ttgggcagac caaaatgcac ggggaaaata      300

ccctcggcaa gagtttcaat actccatgaa gtcagacctg ttacatctgg gtgctttcct      360

ataatgcacg acagaacaaa aattagacag ctgcctaacc ttctccgagg atacgaacat      420

atcaggttat caacccataa cgttatcaat gcagaaaatg caccaggagg accctacaaa      480

attggaacct cagggtcttg ccctaacatt accaatggaa acggattttt cgcaacaatg      540

gcttgggccg tcccaaaaaa cgacaaaaac aaaacagcaa caaatccatt aacaatagaa      600

gtaccataca tttgtacaga aggagaagac caaattaccg tttgggggtt ccactctgac      660

aacgagaccc aaatggcaaa gctctatggg gactcaaagc cccagaagtt cacctcatct      720

gccaacggag tgaccacaca ttacgtttca cagattggtg gcttcccaaa tcaaacagaa      780

gacggaggac taccacaaag tggtagaatt gttgttgatt acatggtgca aaaatctggg      840

aaaacaggaa caattaccta tcaaaggggt attttattgc ctcaaaaggt gtggtgcgca      900

agtggcagga gcaaggtaat aaaaggatcc ttgcctttaa ttggagaagc agattgcctc      960

cacgaaaaat acggtggatt aaacaaaagc aagccttact acacagggga acatgcaaag     1020

gccataggaa attgcccaat atgggtgaaa acacccttga agctggccaa tggaaccaaa     1080

tatagacctc ctggtggagg atgggaagga atgattgcag gttggcacgg atacacatcc     1140

catggggcac atggagtagc ggtggcagca gaccttaaga gcactcaaga ggccataaac     1200

aagataacaa aaaatctcaa ctctttgagt gagctggaag taaagaatct tcaaagacta     1260

agcggtgcca tggatgaact ccacaacgaa atactagaac tagatgagaa agtggatgat     1320

ctcagagctg atacaataag ctcacaaata gaactcgcag tcctgctttc caatgaagga     1380

ataataaaca gtgaagatga acatctcttg gcgcttgaaa gaaagctgaa gaaaatgctg     1440

ggcccctctg ctgtagagat agggaatgga tgctttgaaa ccaaacacaa gtgcaaccag     1500

acctgtctcg acagaatagc tgctggtacc tttgatgcag gagaattttc tctccccacc     1560

tttgattcac tgaatattac tgctgcatct ttaaatgacg atggattgga taatcatact     1620

atactgcttt actactcaac tgctgcctcc agtttggctg taacactgat gatagctatc     1680

tttgttgttt atatggtctc cagagacaat gtttcttgct ccatctgtct ataa           1734


<210>  44
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of PDISP/HA B Brisbane (PrL-).

<400>  44

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Asp Arg Ile Cys Thr Gly Ile Thr 
            20                  25                  30          


Ser Ser Asn Ser Pro His Val Val Lys Thr Ala Thr Gln Gly Glu Val 
        35                  40                  45              


Asn Val Thr Gly Val Ile Pro Leu Thr Thr Thr Pro Thr Lys Ser His 
    50                  55                  60                  


Phe Ala Asn Leu Lys Gly Thr Glu Thr Arg Gly Lys Leu Cys Pro Lys 
65                  70                  75                  80  


Cys Leu Asn Cys Thr Asp Leu Asp Val Ala Leu Gly Arg Pro Lys Cys 
                85                  90                  95      


Thr Gly Lys Ile Pro Ser Ala Arg Val Ser Ile Leu His Glu Val Arg 
            100                 105                 110         


Pro Val Thr Ser Gly Cys Phe Pro Ile Met His Asp Arg Thr Lys Ile 
        115                 120                 125             


Arg Gln Leu Pro Asn Leu Leu Arg Gly Tyr Glu His Ile Arg Leu Ser 
    130                 135                 140                 


Thr His Asn Val Ile Asn Ala Glu Asn Ala Pro Gly Gly Pro Tyr Lys 
145                 150                 155                 160 


Ile Gly Thr Ser Gly Ser Cys Pro Asn Ile Thr Asn Gly Asn Gly Phe 
                165                 170                 175     


Phe Ala Thr Met Ala Trp Ala Val Pro Lys Asn Asp Lys Asn Lys Thr 
            180                 185                 190         


Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile Cys Thr Glu Gly 
        195                 200                 205             


Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp Asn Glu Thr Gln 
    210                 215                 220                 


Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys Phe Thr Ser Ser 
225                 230                 235                 240 


Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile Gly Gly Phe Pro 
                245                 250                 255     


Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly Arg Ile Val Val 
            260                 265                 270         


Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr Ile Thr Tyr Gln 
        275                 280                 285             


Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala Ser Gly Arg Ser 
    290                 295                 300                 


Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu Ala Asp Cys Leu 
305                 310                 315                 320 


His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro Tyr Tyr Thr Gly 
                325                 330                 335     


Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp Val Lys Thr Pro 
            340                 345                 350         


Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Gly Gly Gly Trp 
        355                 360                 365             


Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly Ala His 
    370                 375                 380                 


Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala Ile Asn 
385                 390                 395                 400 


Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Val Lys Asn 
                405                 410                 415     


Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu His Asn Glu Ile Leu 
            420                 425                 430         


Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala Asp Thr Ile Ser Ser 
        435                 440                 445             


Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser 
    450                 455                 460                 


Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu 
465                 470                 475                 480 


Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His 
                485                 490                 495     


Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp 
            500                 505                 510         


Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala 
        515                 520                 525             


Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn His Thr Ile Leu Leu Tyr 
    530                 535                 540                 


Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val Thr Leu Met Ile Ala Ile 
545                 550                 555                 560 


Phe Val Val Tyr Met Val Ser Arg Asp Asn Val Ser Cys Ser Ile Cys 
                565                 570                 575     


Leu 
    


<210>  45
<211>  1734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of PDISP/HA B Brisbane (PrL-)+H1 California 
       TMCT

<400>  45
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg ccgatcgaat ctgcactgga ataacatcgt caaactcacc acatgtcgtc      120

aaaactgcta ctcaagggga ggtcaatgtg actggtgtaa taccactgac aacaacaccc      180

accaaatctc attttgcaaa tctcaaagga acagaaacca gggggaaact atgcccaaaa      240

tgcctcaact gcacagatct ggacgtagcc ttgggcagac caaaatgcac ggggaaaata      300

ccctcggcaa gagtttcaat actccatgaa gtcagacctg ttacatctgg gtgctttcct      360

ataatgcacg acagaacaaa aattagacag ctgcctaacc ttctccgagg atacgaacat      420

atcaggttat caacccataa cgttatcaat gcagaaaatg caccaggagg accctacaaa      480

attggaacct cagggtcttg ccctaacatt accaatggaa acggattttt cgcaacaatg      540

gcttgggccg tcccaaaaaa cgacaaaaac aaaacagcaa caaatccatt aacaatagaa      600

gtaccataca tttgtacaga aggagaagac caaattaccg tttgggggtt ccactctgac      660

aacgagaccc aaatggcaaa gctctatggg gactcaaagc cccagaagtt cacctcatct      720

gccaacggag tgaccacaca ttacgtttca cagattggtg gcttcccaaa tcaaacagaa      780

gacggaggac taccacaaag tggtagaatt gttgttgatt acatggtgca aaaatctggg      840

aaaacaggaa caattaccta tcaaaggggt attttattgc ctcaaaaggt gtggtgcgca      900

agtggcagga gcaaggtaat aaaaggatcc ttgcctttaa ttggagaagc agattgcctc      960

cacgaaaaat acggtggatt aaacaaaagc aagccttact acacagggga acatgcaaag     1020

gccataggaa attgcccaat atgggtgaaa acacccttga agctggccaa tggaaccaaa     1080

tatagacctc ctggtggagg atgggaagga atgattgcag gttggcacgg atacacatcc     1140

catggggcac atggagtagc ggtggcagca gaccttaaga gcactcaaga ggccataaac     1200

aagataacaa aaaatctcaa ctctttgagt gagctggaag taaagaatct tcaaagacta     1260

agcggtgcca tggatgaact ccacaacgaa atactagaac tagatgagaa agtggatgat     1320

ctcagagctg atacaataag ctcacaaata gaactcgcag tcctgctttc caatgaagga     1380

ataataaaca gtgaagatga acatctcttg gcgcttgaaa gaaagctgaa gaaaatgctg     1440

ggcccctctg ctgtagagat agggaatgga tgctttgaaa ccaaacacaa gtgcaaccag     1500

acctgtctcg acagaatagc tgctggtacc tttgatgcag gagaattttc tctccccacc     1560

tttgattcac tgaatattac tgctgcatct ttaaatgacg atggattgga taattaccag     1620

attttggcga tctattcaac tgtcgccagt tcattggtac tggtagtctc cctgggggca     1680

atcagtttct ggatgtgctc taatgggtct ctacagtgta gaatatgtat ttaa           1734


<210>  46
<211>  577
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of PDISP/HA B Brisbane (PrL-)+H1 California 
       TMCT

<400>  46

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Asp Arg Ile Cys Thr Gly Ile Thr 
            20                  25                  30          


Ser Ser Asn Ser Pro His Val Val Lys Thr Ala Thr Gln Gly Glu Val 
        35                  40                  45              


Asn Val Thr Gly Val Ile Pro Leu Thr Thr Thr Pro Thr Lys Ser His 
    50                  55                  60                  


Phe Ala Asn Leu Lys Gly Thr Glu Thr Arg Gly Lys Leu Cys Pro Lys 
65                  70                  75                  80  


Cys Leu Asn Cys Thr Asp Leu Asp Val Ala Leu Gly Arg Pro Lys Cys 
                85                  90                  95      


Thr Gly Lys Ile Pro Ser Ala Arg Val Ser Ile Leu His Glu Val Arg 
            100                 105                 110         


Pro Val Thr Ser Gly Cys Phe Pro Ile Met His Asp Arg Thr Lys Ile 
        115                 120                 125             


Arg Gln Leu Pro Asn Leu Leu Arg Gly Tyr Glu His Ile Arg Leu Ser 
    130                 135                 140                 


Thr His Asn Val Ile Asn Ala Glu Asn Ala Pro Gly Gly Pro Tyr Lys 
145                 150                 155                 160 


Ile Gly Thr Ser Gly Ser Cys Pro Asn Ile Thr Asn Gly Asn Gly Phe 
                165                 170                 175     


Phe Ala Thr Met Ala Trp Ala Val Pro Lys Asn Asp Lys Asn Lys Thr 
            180                 185                 190         


Ala Thr Asn Pro Leu Thr Ile Glu Val Pro Tyr Ile Cys Thr Glu Gly 
        195                 200                 205             


Glu Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp Asn Glu Thr Gln 
    210                 215                 220                 


Met Ala Lys Leu Tyr Gly Asp Ser Lys Pro Gln Lys Phe Thr Ser Ser 
225                 230                 235                 240 


Ala Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile Gly Gly Phe Pro 
                245                 250                 255     


Asn Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly Arg Ile Val Val 
            260                 265                 270         


Asp Tyr Met Val Gln Lys Ser Gly Lys Thr Gly Thr Ile Thr Tyr Gln 
        275                 280                 285             


Arg Gly Ile Leu Leu Pro Gln Lys Val Trp Cys Ala Ser Gly Arg Ser 
    290                 295                 300                 


Lys Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu Ala Asp Cys Leu 
305                 310                 315                 320 


His Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro Tyr Tyr Thr Gly 
                325                 330                 335     


Glu His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp Val Lys Thr Pro 
            340                 345                 350         


Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Gly Gly Gly Trp 
        355                 360                 365             


Glu Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly Ala His 
    370                 375                 380                 


Gly Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala Ile Asn 
385                 390                 395                 400 


Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Val Lys Asn 
                405                 410                 415     


Leu Gln Arg Leu Ser Gly Ala Met Asp Glu Leu His Asn Glu Ile Leu 
            420                 425                 430         


Glu Leu Asp Glu Lys Val Asp Asp Leu Arg Ala Asp Thr Ile Ser Ser 
        435                 440                 445             


Gln Ile Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser 
    450                 455                 460                 


Glu Asp Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu 
465                 470                 475                 480 


Gly Pro Ser Ala Val Glu Ile Gly Asn Gly Cys Phe Glu Thr Lys His 
                485                 490                 495     


Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asp 
            500                 505                 510         


Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala 
        515                 520                 525             


Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn Tyr Gln Ile Leu Ala Ile 
    530                 535                 540                 


Tyr Ser Thr Val Ala Ser Ser Leu Val Leu Val Val Ser Leu Gly Ala 
545                 550                 555                 560 


Ile Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys 
                565                 570                 575     


Ile 
    


<210>  47
<211>  1731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of PDISP/HA B Massachussetts (PrL-).

<400>  47
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg ccgatcgaat ctgcactggg ataacatctt caaactcacc tcatgtggtc      120

aaaacagcta ctcaagggga ggtcaatgtg actggtgtga taccactaac aacaacacca      180

acaaaatctt attttgcaaa tctcaaagga acaaagacca gagggaaact atgcccagac      240

tgtctcaact gtacagatct ggatgtggcc ctgggcaggc caatgtgtgt gggaactaca      300

ccttctgcga aagcttcaat acttcacgaa gtcagacctg ttacatccgg gtgcttccct      360

ataatgcacg acagaacaaa aatcaggcaa ctagccaatc ttctcagagg atatgaaaat      420

atcaggttat caacccaaaa cgttatcgat gcagaaaagg caccaggagg accctacaga      480

cttggaacct caggatcttg ccctaacgct accagtaaaa gcggattttt cgcaacaatg      540

gcttgggctg tcccaaagga caacaacaaa aatgcaacga acccattaac agtagaagta      600

ccatacattt gtgcagaagg ggaagaccaa attactgttt gggggttcca ttcagataac      660

aaaacccaaa tgaagaacct ctatggagac tcaaatcctc aaaagttcac ctcatctgct      720

aatggagtaa ccacacatta tgtttctcag attggcggct tcccagatca aacagaagac      780

ggaggactac cacaaagcgg cagaattgtc gttgattaca tgatgcaaaa acctgggaaa      840

acaggaacaa ttgtctatca aagaggtgtt ttgttgcctc aaaaggtgtg gtgcgcgagt      900

ggcaggagca aagtaataaa agggtccttg cctttaattg gtgaagcaga ttgccttcat      960

gaaaaatacg gtggattaaa caaaagcaag ccttactaca caggagaaca tgcaaaagcc     1020

ataggaaatt gcccaatatg ggtgaaaaca cctttgaagc ttgccaatgg aaccaaatat     1080

agacctcctg gtggaggatg ggaaggaatg attgcaggtt ggcacggata cacatctcac     1140

ggagcacatg gagtggcagt tgctgcagac cttaagagca cacaagaagc tataaacaag     1200

ataacaaaaa atctcaactc tttgagtgag ctagaagtaa agaatcttca aaggctaagt     1260

ggtgccatgg atgaactcca caacgaaata ctcgagctgg atgagaaagt ggatgacctc     1320

agagctgaca ctataagttc acaaatagaa cttgcagtct tgctttccaa cgaaggaata     1380

ataaacagtg aagacgagca tctattggca cttgagagaa aactaaagaa aatgctgggt     1440

ccctctgctg tagacatagg aaatggatgc ttcgaaacca aacacaaatg caaccagacc     1500

tgcttagaca ggatagctgc tggcaccttt aatgcaggag agttttctct ccccactttt     1560

gattcattga acattactgc tgcatcttta aatgatgatg gattggataa ccatactata     1620

ctgctctatt actcaactgc tgcttctagt ttggctgtaa cattgatgct agctattttt     1680

attgtttata tggtctccag agacaacgtt tcatgctcca tctgtctata a              1731


<210>  48
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of PDISP/HA B Massachussetts (PrL-).

<400>  48

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Asp Arg Ile Cys Thr Gly Ile Thr 
            20                  25                  30          


Ser Ser Asn Ser Pro His Val Val Lys Thr Ala Thr Gln Gly Glu Val 
        35                  40                  45              


Asn Val Thr Gly Val Ile Pro Leu Thr Thr Thr Pro Thr Lys Ser Tyr 
    50                  55                  60                  


Phe Ala Asn Leu Lys Gly Thr Lys Thr Arg Gly Lys Leu Cys Pro Asp 
65                  70                  75                  80  


Cys Leu Asn Cys Thr Asp Leu Asp Val Ala Leu Gly Arg Pro Met Cys 
                85                  90                  95      


Val Gly Thr Thr Pro Ser Ala Lys Ala Ser Ile Leu His Glu Val Arg 
            100                 105                 110         


Pro Val Thr Ser Gly Cys Phe Pro Ile Met His Asp Arg Thr Lys Ile 
        115                 120                 125             


Arg Gln Leu Ala Asn Leu Leu Arg Gly Tyr Glu Asn Ile Arg Leu Ser 
    130                 135                 140                 


Thr Gln Asn Val Ile Asp Ala Glu Lys Ala Pro Gly Gly Pro Tyr Arg 
145                 150                 155                 160 


Leu Gly Thr Ser Gly Ser Cys Pro Asn Ala Thr Ser Lys Ser Gly Phe 
                165                 170                 175     


Phe Ala Thr Met Ala Trp Ala Val Pro Lys Asp Asn Asn Lys Asn Ala 
            180                 185                 190         


Thr Asn Pro Leu Thr Val Glu Val Pro Tyr Ile Cys Ala Glu Gly Glu 
        195                 200                 205             


Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp Asn Lys Thr Gln Met 
    210                 215                 220                 


Lys Asn Leu Tyr Gly Asp Ser Asn Pro Gln Lys Phe Thr Ser Ser Ala 
225                 230                 235                 240 


Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile Gly Gly Phe Pro Asp 
                245                 250                 255     


Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly Arg Ile Val Val Asp 
            260                 265                 270         


Tyr Met Met Gln Lys Pro Gly Lys Thr Gly Thr Ile Val Tyr Gln Arg 
        275                 280                 285             


Gly Val Leu Leu Pro Gln Lys Val Trp Cys Ala Ser Gly Arg Ser Lys 
    290                 295                 300                 


Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu Ala Asp Cys Leu His 
305                 310                 315                 320 


Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro Tyr Tyr Thr Gly Glu 
                325                 330                 335     


His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp Val Lys Thr Pro Leu 
            340                 345                 350         


Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Gly Gly Gly Trp Glu 
        355                 360                 365             


Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly Ala His Gly 
    370                 375                 380                 


Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys 
385                 390                 395                 400 


Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Val Lys Asn Leu 
                405                 410                 415     


Gln Arg Leu Ser Gly Ala Met Asp Glu Leu His Asn Glu Ile Leu Glu 
            420                 425                 430         


Leu Asp Glu Lys Val Asp Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln 
        435                 440                 445             


Ile Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu 
    450                 455                 460                 


Asp Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu Gly 
465                 470                 475                 480 


Pro Ser Ala Val Asp Ile Gly Asn Gly Cys Phe Glu Thr Lys His Lys 
                485                 490                 495     


Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asn Ala 
            500                 505                 510         


Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala 
        515                 520                 525             


Ser Leu Asn Asp Asp Gly Leu Asp Asn His Thr Ile Leu Leu Tyr Tyr 
    530                 535                 540                 


Ser Thr Ala Ala Ser Ser Leu Ala Val Thr Leu Met Leu Ala Ile Phe 
545                 550                 555                 560 


Ile Val Tyr Met Val Ser Arg Asp Asn Val Ser Cys Ser Ile Cys Leu 
                565                 570                 575     


<210>  49
<211>  1731
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of PDISP/HA B Massachussetts (PrL-)+H1 
       California TMCT

<400>  49
atggcgaaaa acgttgcgat tttcggctta ttgttttctc ttcttgtgtt ggttccttct       60

cagatcttcg ccgatcgaat ctgcactggg ataacatctt caaactcacc tcatgtggtc      120

aaaacagcta ctcaagggga ggtcaatgtg actggtgtga taccactaac aacaacacca      180

acaaaatctt attttgcaaa tctcaaagga acaaagacca gagggaaact atgcccagac      240

tgtctcaact gtacagatct ggatgtggcc ctgggcaggc caatgtgtgt gggaactaca      300

ccttctgcga aagcttcaat acttcacgaa gtcagacctg ttacatccgg gtgcttccct      360

ataatgcacg acagaacaaa aatcaggcaa ctagccaatc ttctcagagg atatgaaaat      420

atcaggttat caacccaaaa cgttatcgat gcagaaaagg caccaggagg accctacaga      480

cttggaacct caggatcttg ccctaacgct accagtaaaa gcggattttt cgcaacaatg      540

gcttgggctg tcccaaagga caacaacaaa aatgcaacga acccattaac agtagaagta      600

ccatacattt gtgcagaagg ggaagaccaa attactgttt gggggttcca ttcagataac      660

aaaacccaaa tgaagaacct ctatggagac tcaaatcctc aaaagttcac ctcatctgct      720

aatggagtaa ccacacatta tgtttctcag attggcggct tcccagatca aacagaagac      780

ggaggactac cacaaagcgg cagaattgtc gttgattaca tgatgcaaaa acctgggaaa      840

acaggaacaa ttgtctatca aagaggtgtt ttgttgcctc aaaaggtgtg gtgcgcgagt      900

ggcaggagca aagtaataaa agggtccttg cctttaattg gtgaagcaga ttgccttcat      960

gaaaaatacg gtggattaaa caaaagcaag ccttactaca caggagaaca tgcaaaagcc     1020

ataggaaatt gcccaatatg ggtgaaaaca cctttgaagc ttgccaatgg aaccaaatat     1080

agacctcctg gtggaggatg ggaaggaatg attgcaggtt ggcacggata cacatctcac     1140

ggagcacatg gagtggcagt tgctgcagac cttaagagca cacaagaagc tataaacaag     1200

ataacaaaaa atctcaactc tttgagtgag ctagaagtaa agaatcttca aaggctaagt     1260

ggtgccatgg atgaactcca caacgaaata ctcgagctgg atgagaaagt ggatgacctc     1320

agagctgaca ctataagttc acaaatagaa cttgcagtct tgctttccaa cgaaggaata     1380

ataaacagtg aagacgagca tctattggca cttgagagaa aactaaagaa aatgctgggt     1440

ccctctgctg tagacatagg aaatggatgc ttcgaaacca aacacaaatg caaccagacc     1500

tgcttagaca ggatagctgc tggcaccttt aatgcaggag agttttctct ccccactttt     1560

gattcattga acattactgc tgcatcttta aatgatgatg gattggataa ctaccagatt     1620

ttggcgatct attcaactgt cgccagttca ttggtactgg tagtctccct gggggcaatc     1680

agtttctgga tgtgctctaa tgggtctcta cagtgtagaa tatgtattta a              1731


<210>  50
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of PDISP/HA B Massachussetts (PrL-)+H1 
       California TMCT

<400>  50

Met Ala Lys Asn Val Ala Ile Phe Gly Leu Leu Phe Ser Leu Leu Val 
1               5                   10                  15      


Leu Val Pro Ser Gln Ile Phe Ala Asp Arg Ile Cys Thr Gly Ile Thr 
            20                  25                  30          


Ser Ser Asn Ser Pro His Val Val Lys Thr Ala Thr Gln Gly Glu Val 
        35                  40                  45              


Asn Val Thr Gly Val Ile Pro Leu Thr Thr Thr Pro Thr Lys Ser Tyr 
    50                  55                  60                  


Phe Ala Asn Leu Lys Gly Thr Lys Thr Arg Gly Lys Leu Cys Pro Asp 
65                  70                  75                  80  


Cys Leu Asn Cys Thr Asp Leu Asp Val Ala Leu Gly Arg Pro Met Cys 
                85                  90                  95      


Val Gly Thr Thr Pro Ser Ala Lys Ala Ser Ile Leu His Glu Val Arg 
            100                 105                 110         


Pro Val Thr Ser Gly Cys Phe Pro Ile Met His Asp Arg Thr Lys Ile 
        115                 120                 125             


Arg Gln Leu Ala Asn Leu Leu Arg Gly Tyr Glu Asn Ile Arg Leu Ser 
    130                 135                 140                 


Thr Gln Asn Val Ile Asp Ala Glu Lys Ala Pro Gly Gly Pro Tyr Arg 
145                 150                 155                 160 


Leu Gly Thr Ser Gly Ser Cys Pro Asn Ala Thr Ser Lys Ser Gly Phe 
                165                 170                 175     


Phe Ala Thr Met Ala Trp Ala Val Pro Lys Asp Asn Asn Lys Asn Ala 
            180                 185                 190         


Thr Asn Pro Leu Thr Val Glu Val Pro Tyr Ile Cys Ala Glu Gly Glu 
        195                 200                 205             


Asp Gln Ile Thr Val Trp Gly Phe His Ser Asp Asn Lys Thr Gln Met 
    210                 215                 220                 


Lys Asn Leu Tyr Gly Asp Ser Asn Pro Gln Lys Phe Thr Ser Ser Ala 
225                 230                 235                 240 


Asn Gly Val Thr Thr His Tyr Val Ser Gln Ile Gly Gly Phe Pro Asp 
                245                 250                 255     


Gln Thr Glu Asp Gly Gly Leu Pro Gln Ser Gly Arg Ile Val Val Asp 
            260                 265                 270         


Tyr Met Met Gln Lys Pro Gly Lys Thr Gly Thr Ile Val Tyr Gln Arg 
        275                 280                 285             


Gly Val Leu Leu Pro Gln Lys Val Trp Cys Ala Ser Gly Arg Ser Lys 
    290                 295                 300                 


Val Ile Lys Gly Ser Leu Pro Leu Ile Gly Glu Ala Asp Cys Leu His 
305                 310                 315                 320 


Glu Lys Tyr Gly Gly Leu Asn Lys Ser Lys Pro Tyr Tyr Thr Gly Glu 
                325                 330                 335     


His Ala Lys Ala Ile Gly Asn Cys Pro Ile Trp Val Lys Thr Pro Leu 
            340                 345                 350         


Lys Leu Ala Asn Gly Thr Lys Tyr Arg Pro Pro Gly Gly Gly Trp Glu 
        355                 360                 365             


Gly Met Ile Ala Gly Trp His Gly Tyr Thr Ser His Gly Ala His Gly 
    370                 375                 380                 


Val Ala Val Ala Ala Asp Leu Lys Ser Thr Gln Glu Ala Ile Asn Lys 
385                 390                 395                 400 


Ile Thr Lys Asn Leu Asn Ser Leu Ser Glu Leu Glu Val Lys Asn Leu 
                405                 410                 415     


Gln Arg Leu Ser Gly Ala Met Asp Glu Leu His Asn Glu Ile Leu Glu 
            420                 425                 430         


Leu Asp Glu Lys Val Asp Asp Leu Arg Ala Asp Thr Ile Ser Ser Gln 
        435                 440                 445             


Ile Glu Leu Ala Val Leu Leu Ser Asn Glu Gly Ile Ile Asn Ser Glu 
    450                 455                 460                 


Asp Glu His Leu Leu Ala Leu Glu Arg Lys Leu Lys Lys Met Leu Gly 
465                 470                 475                 480 


Pro Ser Ala Val Asp Ile Gly Asn Gly Cys Phe Glu Thr Lys His Lys 
                485                 490                 495     


Cys Asn Gln Thr Cys Leu Asp Arg Ile Ala Ala Gly Thr Phe Asn Ala 
            500                 505                 510         


Gly Glu Phe Ser Leu Pro Thr Phe Asp Ser Leu Asn Ile Thr Ala Ala 
        515                 520                 525             


Ser Leu Asn Asp Asp Gly Leu Asp Asn Tyr Gln Ile Leu Ala Ile Tyr 
    530                 535                 540                 


Ser Thr Val Ala Ser Ser Leu Val Leu Val Val Ser Leu Gly Ala Ile 
545                 550                 555                 560 


Ser Phe Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
                565                 570                 575     


<210>  51
<211>  1704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of HA B Wisconsin (PrL-).

<400>  51
atgaaggcaa taattgtact actcatggta gtaacatcca atgcagatcg aatctgcact       60

gggataacat cttcaaactc acctcatgtg gtcaaaacag ctactcaagg ggaggtcaat      120

gtgactggcg tgataccact gacaacaaca ccaacaaaat cttattttgc aaatctcaaa      180

ggaacaagga ccagagggaa actatgcccg gactgtctca actgtacaga tctggatgtg      240

gccttgggca ggccaatgtg tgtggggacc acaccttctg ctaaagcttc aatactccac      300

gaggtcagac ctgttacatc cgggtgcttt cctataatgc acgacagaac aaaaatcagg      360

caactaccca atcttctcag aggatatgaa aatatcaggt tatcaaccca aaacgttatc      420

gatgcagaaa aagcaccagg aggaccctac agacttggaa cctcaggatc ttgccctaac      480

gctaccagta aaatcggatt ttttgcaaca atggcttggg ctgtcccaaa ggacaactac      540

aaaaatgcaa cgaacccact aacagtagaa gtaccataca tttgtacaga aggggaagac      600

caaattactg tttgggggtt ccattcagat aacaaaaccc aaatgaagag cctctatgga      660

gactcaaatc ctcaaaagtt cacctcatct gctaatggag taaccacaca ttatgtttct      720

cagattggcg acttcccaga tcaaacagaa gacggaggac taccacaaag cggcagaatt      780

gttgttgatt acatgatgca aaaacctggg aaaacaggaa caattgtcta tcaaagaggt      840

gttttgttgc ctcaaaaggt gtggtgcgcg agtggcagga gcaaagtaat aaaagggtca      900

ttgcctttaa ttggtgaagc agattgcctt catgaaaaat acggtggatt aaacaaaagc      960

aagccttact acacaggaga acatgcaaaa gccataggaa attgcccaat atgggtaaaa     1020

acacctttga agcttgccaa tggaaccaaa tatagacctc ctggtggagg atgggaagga     1080

atgattgcag gttggcacgg atacacatct cacggagcac atggagtggc agtggcggca     1140

gaccttaaga gtacacaaga agctataaat aagataacaa aaaatctcaa ttctttgagt     1200

gagctagaag taaagaacct tcaaagacta agtggtgcca tggatgaact ccacaacgaa     1260

atactcgagc tggatgagaa agtggatgat ctcagagctg acactataag ctcacaaata     1320

gaacttgcag tcttgctttc caacgaagga ataataaaca gtgaagacga gcatctattg     1380

gcacttgaga gaaaactaaa gaaaatgctg ggtccctctg ctgtagacat aggaaacgga     1440

tgcttcgaaa ccaaacacaa atgcaaccag acctgcttag acaggatagc tgctggcacc     1500

tttaatgcag gagaattttc tctccccact tttgattcat tgaacattac tgctgcatct     1560

ttaaatgatg atggattgga taaccatact atactgctct attactcaac tgctgcttct     1620

agtttggctg taacattaat gctagctatt tttattgttt atatggtctc cagagacaac     1680

gtttcatgct ccatctgtct ataa                                            1704


<210>  52
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of HA B Wisconsin (PrL-).

<400>  52

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ala Thr Ser Lys Ile Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asp Asn Tyr Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asn Lys Thr Gln Met Lys Ser Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Asp Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Gly Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr 
        355                 360                 365             


Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser 
385                 390                 395                 400 


Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu 
                405                 410                 415     


Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg 
            420                 425                 430         


Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn 
        435                 440                 445             


Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg 
    450                 455                 460                 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile 
                485                 490                 495     


Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
            500                 505                 510         


Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn 
        515                 520                 525             


His Thr Ile Leu Leu Tyr Tyr Ser Thr Ala Ala Ser Ser Leu Ala Val 
    530                 535                 540                 


Thr Leu Met Leu Ala Ile Phe Ile Val Tyr Met Val Ser Arg Asp Asn 
545                 550                 555                 560 


Val Ser Cys Ser Ile Cys Leu 
                565         


<210>  53
<211>  1704
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of HA B Wisconsin (PrL-)+H1 California TMCT

<400>  53
atgaaggcaa taattgtact actcatggta gtaacatcca atgcagatcg aatctgcact       60

gggataacat cttcaaactc acctcatgtg gtcaaaacag ctactcaagg ggaggtcaat      120

gtgactggcg tgataccact gacaacaaca ccaacaaaat cttattttgc aaatctcaaa      180

ggaacaagga ccagagggaa actatgcccg gactgtctca actgtacaga tctggatgtg      240

gccttgggca ggccaatgtg tgtggggacc acaccttctg ctaaagcttc aatactccac      300

gaggtcagac ctgttacatc cgggtgcttt cctataatgc acgacagaac aaaaatcagg      360

caactaccca atcttctcag aggatatgaa aatatcaggt tatcaaccca aaacgttatc      420

gatgcagaaa aagcaccagg aggaccctac agacttggaa cctcaggatc ttgccctaac      480

gctaccagta aaatcggatt ttttgcaaca atggcttggg ctgtcccaaa ggacaactac      540

aaaaatgcaa cgaacccact aacagtagaa gtaccataca tttgtacaga aggggaagac      600

caaattactg tttgggggtt ccattcagat aacaaaaccc aaatgaagag cctctatgga      660

gactcaaatc ctcaaaagtt cacctcatct gctaatggag taaccacaca ttatgtttct      720

cagattggcg acttcccaga tcaaacagaa gacggaggac taccacaaag cggcagaatt      780

gttgttgatt acatgatgca aaaacctggg aaaacaggaa caattgtcta tcaaagaggt      840

gttttgttgc ctcaaaaggt gtggtgcgcg agtggcagga gcaaagtaat aaaagggtca      900

ttgcctttaa ttggtgaagc agattgcctt catgaaaaat acggtggatt aaacaaaagc      960

aagccttact acacaggaga acatgcaaaa gccataggaa attgcccaat atgggtaaaa     1020

acacctttga agcttgccaa tggaaccaaa tatagacctc ctggtggagg atgggaagga     1080

atgattgcag gttggcacgg atacacatct cacggagcac atggagtggc agtggcggca     1140

gaccttaaga gtacacaaga agctataaat aagataacaa aaaatctcaa ttctttgagt     1200

gagctagaag taaagaacct tcaaagacta agtggtgcca tggatgaact ccacaacgaa     1260

atactcgagc tggatgagaa agtggatgat ctcagagctg acactataag ctcacaaata     1320

gaacttgcag tcttgctttc caacgaagga ataataaaca gtgaagacga gcatctattg     1380

gcacttgaga gaaaactaaa gaaaatgctg ggtccctctg ctgtagacat aggaaacgga     1440

tgcttcgaaa ccaaacacaa atgcaaccag acctgcttag acaggatagc tgctggcacc     1500

tttaatgcag gagaattttc tctccccact tttgattcat tgaacattac tgctgcatct     1560

ttaaatgatg atggattgga taactaccag attttggcga tctattcaac tgtcgccagt     1620

tcattggtac tggtagtctc cctgggggca atcagtttct ggatgtgctc taatgggtct     1680

ctacagtgta gaatatgtat ttaa                                            1704


<210>  54
<211>  567
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of HA B Wisconsin (PrL-)+H1 California TMC

<400>  54

Met Lys Ala Ile Ile Val Leu Leu Met Val Val Thr Ser Asn Ala Asp 
1               5                   10                  15      


Arg Ile Cys Thr Gly Ile Thr Ser Ser Asn Ser Pro His Val Val Lys 
            20                  25                  30          


Thr Ala Thr Gln Gly Glu Val Asn Val Thr Gly Val Ile Pro Leu Thr 
        35                  40                  45              


Thr Thr Pro Thr Lys Ser Tyr Phe Ala Asn Leu Lys Gly Thr Arg Thr 
    50                  55                  60                  


Arg Gly Lys Leu Cys Pro Asp Cys Leu Asn Cys Thr Asp Leu Asp Val 
65                  70                  75                  80  


Ala Leu Gly Arg Pro Met Cys Val Gly Thr Thr Pro Ser Ala Lys Ala 
                85                  90                  95      


Ser Ile Leu His Glu Val Arg Pro Val Thr Ser Gly Cys Phe Pro Ile 
            100                 105                 110         


Met His Asp Arg Thr Lys Ile Arg Gln Leu Pro Asn Leu Leu Arg Gly 
        115                 120                 125             


Tyr Glu Asn Ile Arg Leu Ser Thr Gln Asn Val Ile Asp Ala Glu Lys 
    130                 135                 140                 


Ala Pro Gly Gly Pro Tyr Arg Leu Gly Thr Ser Gly Ser Cys Pro Asn 
145                 150                 155                 160 


Ala Thr Ser Lys Ile Gly Phe Phe Ala Thr Met Ala Trp Ala Val Pro 
                165                 170                 175     


Lys Asp Asn Tyr Lys Asn Ala Thr Asn Pro Leu Thr Val Glu Val Pro 
            180                 185                 190         


Tyr Ile Cys Thr Glu Gly Glu Asp Gln Ile Thr Val Trp Gly Phe His 
        195                 200                 205             


Ser Asp Asn Lys Thr Gln Met Lys Ser Leu Tyr Gly Asp Ser Asn Pro 
    210                 215                 220                 


Gln Lys Phe Thr Ser Ser Ala Asn Gly Val Thr Thr His Tyr Val Ser 
225                 230                 235                 240 


Gln Ile Gly Asp Phe Pro Asp Gln Thr Glu Asp Gly Gly Leu Pro Gln 
                245                 250                 255     


Ser Gly Arg Ile Val Val Asp Tyr Met Met Gln Lys Pro Gly Lys Thr 
            260                 265                 270         


Gly Thr Ile Val Tyr Gln Arg Gly Val Leu Leu Pro Gln Lys Val Trp 
        275                 280                 285             


Cys Ala Ser Gly Arg Ser Lys Val Ile Lys Gly Ser Leu Pro Leu Ile 
    290                 295                 300                 


Gly Glu Ala Asp Cys Leu His Glu Lys Tyr Gly Gly Leu Asn Lys Ser 
305                 310                 315                 320 


Lys Pro Tyr Tyr Thr Gly Glu His Ala Lys Ala Ile Gly Asn Cys Pro 
                325                 330                 335     


Ile Trp Val Lys Thr Pro Leu Lys Leu Ala Asn Gly Thr Lys Tyr Arg 
            340                 345                 350         


Pro Pro Gly Gly Gly Trp Glu Gly Met Ile Ala Gly Trp His Gly Tyr 
        355                 360                 365             


Thr Ser His Gly Ala His Gly Val Ala Val Ala Ala Asp Leu Lys Ser 
    370                 375                 380                 


Thr Gln Glu Ala Ile Asn Lys Ile Thr Lys Asn Leu Asn Ser Leu Ser 
385                 390                 395                 400 


Glu Leu Glu Val Lys Asn Leu Gln Arg Leu Ser Gly Ala Met Asp Glu 
                405                 410                 415     


Leu His Asn Glu Ile Leu Glu Leu Asp Glu Lys Val Asp Asp Leu Arg 
            420                 425                 430         


Ala Asp Thr Ile Ser Ser Gln Ile Glu Leu Ala Val Leu Leu Ser Asn 
        435                 440                 445             


Glu Gly Ile Ile Asn Ser Glu Asp Glu His Leu Leu Ala Leu Glu Arg 
    450                 455                 460                 


Lys Leu Lys Lys Met Leu Gly Pro Ser Ala Val Asp Ile Gly Asn Gly 
465                 470                 475                 480 


Cys Phe Glu Thr Lys His Lys Cys Asn Gln Thr Cys Leu Asp Arg Ile 
                485                 490                 495     


Ala Ala Gly Thr Phe Asn Ala Gly Glu Phe Ser Leu Pro Thr Phe Asp 
            500                 505                 510         


Ser Leu Asn Ile Thr Ala Ala Ser Leu Asn Asp Asp Gly Leu Asp Asn 
        515                 520                 525             


Tyr Gln Ile Leu Ala Ile Tyr Ser Thr Val Ala Ser Ser Leu Val Leu 
    530                 535                 540                 


Val Val Ser Leu Gly Ala Ile Ser Phe Trp Met Cys Ser Asn Gly Ser 
545                 550                 555                 560 


Leu Gln Cys Arg Ile Cys Ile 
                565         


<210>  55
<211>  514
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Segment of native CPMV RNA 2 genome, nucleotides 1-514

<400>  55
tattaaaatc ttaataggtt ttgataaaag cgaacgtggg gaaacccgaa ccaaaccttc       60

ttctaaactc tctctcatct ctcttaaagc aaacttctct cttgtctttc ttgcatgagc      120

gatcttcaac gttgtcagat cgtgcttcgg caccagtaca atgttttctt tcactgaagc      180

gaaatcaaag atctctttgt ggacacgtag tgcggcgcca ttaaataacg tgtacttgtc      240

ctattcttgt cggtgtggtc ttgggaaaag aaagcttgct ggaggctgct gttcagcccc      300

atacattact tgttacgatt ctgctgactt tcggcgggtg caatatctct acttctgctt      360

gacgaggtat tgttgcctgt acttctttct tcttcttctt gctgattggt tctataagaa      420

atctagtatt ttctttgaaa cagagttttc ccgtggtttt cgaacttgga gaaagattgt      480

taagcttctg tatattctgc ccaaatttga aatg                                  514


<210>  56
<211>  511
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CPMV RNA2 genome, nucleotides 1-514, with modifications at 115 
       and 162

<400>  56
tattaaaatc ttaataggtt ttgataaaag cgaacgtggg gaaacccgaa ccaaaccttc       60

ttctaaactc tctctcatct ctcttaaagc aaacttctct cttgtctttc ttgcgtgagc      120

gatcttcaac gttgtcagat cgtgcttcgg caccagtaca acgttttctt tcactgaagc      180

gaaatcaaag atctctttgt ggacacgtag tgcggcgcca ttaaataacg tgtacttgtc      240

ctattcttgt cggtgtggtc ttgggaaaag aaagcttgct ggaggctgct gttcagcccc      300

atacattact tgttacgatt ctgctgactt tcggcgggtg caatatctct acttctgctt      360

gacgaggtat tgttgcctgt acttctttct tcttcttctt gctgattggt tctataagaa      420

atctagtatt ttctttgaaa cagagttttc ccgtggtttt cgaacttgga gaaagattgt      480

taagcttctg tatattctgc ccaaatttga a                                     511


<210>  57
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Patatin signal peptide (nucleotide sequence)

<400>  57
atggcaacta ctaaaacttt tttaatttta ttttttatga tattagcaac tactagttca       60

acatgtgct                                                               69


<210>  58
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Patatin signal peptide (amino acid sequence)

<400>  58

Met Ala Thr Thr Lys Thr Phe Leu Ile Leu Phe Phe Met Ile Leu Ala 
1               5                   10                  15      


Thr Thr Ser Ser Thr Cys Ala 
            20              


<210>  59
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA transmembrane domain consensus amino acid sequence


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<400>  59

Ile Leu Xaa Ile Tyr Tyr Ser Thr Val Ala Ile Ser Ser Leu Xaa Leu 
1               5                   10                  15      


Xaa Xaa Met Leu Ala Gly Xaa Ser Xaa Trp Met Cys Ser 
            20                  25                  


