                         SEQUENCE LISTING

<110>  Pharmacyclics, Inc.
 
<120>  PHOSPHOLIPASE C GAMMA 2 AND RESISTANCE ASSOCIATED MUTATIONS 

<130>  25922-307.102

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  4289
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(4289)
<223>  PLCgamma2

<400>  1
agtagcgagc gccggcggcg gagggcgtga gcggcgctga gtgacccgag tcgggacgcg       60

ggctgcgcgc gcgggacccc ggagcccaaa cccggggcag gcgggcagct gtgcccgggc      120

ggcacggcca gcttcctgat ttctcccgat tccttccttc tccctggagc ggccgacaat      180

gtccaccacg gtcaatgtag attcccttgc ggaatatgag aagagccaga tcaagagagc      240

cctggagctg gggacggtga tgactgtgtt cagcttccgc aagtccaccc ccgagcggag      300

aaccgtccag gtgatcatgg agacgcggca ggtggcctgg agcaagaccg ccgacaagat      360

cgagggcttc ttggatatca tggaaataaa agaaatccgc ccagggaaga actccaaaga      420

tttcgagcga gcaaaagcag ttcgccagaa agaagactgc tgcttcacca tcctatatgg      480

cactcagttc gtcctcagca cgctcagctt ggcagctgac tctaaagagg atgcagttaa      540

ctggctctct ggcttgaaaa tcttacacca ggaagcgatg aatgcgtcca cgcccaccat      600

tatcgagagt tggctgagaa agcagatata ttctgtggat caaaccagaa gaaacagcat      660

cagtctccga gagttgaaga ccatcttgcc cctgatcaac tttaaagtga gcagtgccaa      720

gttccttaaa gataagtttg tggaaatagg agcacacaaa gatgagctca gctttgaaca      780

gttccatctc ttctataaaa aacttatgtt tgaacagcaa aaatcgattc tcgatgaatt      840

caaaaaggat tcgtccgtgt tcatcctggg gaacactgac aggccggatg cctctgctgt      900

ttacctgcat gacttccaga ggtttctcat acatgaacag caggagcatt gggctcagga      960

tctgaacaaa gtccgtgagc ggatgacaaa gttcattgat gacaccatgc gtgaaactgc     1020

tgagcctttc ttgtttgtgg atgagttcct cacgtacctg ttttcacgag aaaacagcat     1080

ctgggatgag aagtatgacg cggtggacat gcaggacatg aacaaccccc tgtctcatta     1140

ctggatctcc tcgtcacata acacgtacct tacaggtgac cagctgcgga gcgagtcgtc     1200

cccagaagct tacatccgct gcctgcgcat gggctgtcgc tgcattgaac tggactgctg     1260

ggacgggccc gatgggaagc cggtcatcta ccatggctgg acgcggacta ccaagatcaa     1320

gtttgacgac gtcgtgcagg ccatcaaaga ccacgccttt gttacctcga gcttcccagt     1380

gatcctgtcc atcgaggagc actgcagcgt ggagcaacag cgtcacatgg ccaaggcctt     1440

caaggaagta tttggcgacc tgctgttgac gaagcccacg gaggccagtg ctgaccagct     1500

gccctcgccc agccagctgc gggagaagat catcatcaag cataagaagc tgggcccccg     1560

aggcgatgtg gatgtcaaca tggaggacaa gaaggacgaa cacaagcaac agggggagct     1620

gtacatgtgg gattccattg accagaaatg gactcggcac tactgcgcca ttgccgatgc     1680

caagctgtcc ttcagtgatg acattgaaca gactatggag gaggaagtgc cccaggatat     1740

accccctaca gaactacatt ttggggagaa atggttccac aagaaggtgg agaagaggac     1800

gagtgccgag aagttgctgc aggaatactg catggagacg gggggcaagg atggcacctt     1860

cctggttcgg gagagcgaga ccttccccaa tgactacacc ctgtccttct ggcggtcagg     1920

ccgggtccag cactgccgga tccgctccac catggagggc gggaccctga aatactactt     1980

gactgacaac ctcaccttca gcagcatcta tgccctcatc cagcactacc gcgagacgca     2040

cctgcgctgc gccgagttcg agctgcggct cacggaccct gtgcccaacc ccaaccccca     2100

cgagtccaag ccgtggtact atgacagcct gagccgcgga gaggcagagg acatgctgat     2160

gaggattccc cgggacgggg ccttcctgat ccggaagcga gaggggagcg actcctatgc     2220

catcaccttc agggctaggg gcaaggtaaa gcattgtcgc atcaaccggg acggccggca     2280

ctttgtgctg gggacctccg cctattttga gagtctggtg gagctcgtca gttactacga     2340

gaagcattca ctctaccgaa agatgagact gcgctacccc gtgacccccg agctcctgga     2400

gcgctacaat atggaaagag atataaactc cctctacgac gtcagcagaa tgtatgtgga     2460

tcccagtgaa atcaatccgt ccatgcctca gagaaccgtg aaagctctgt atgactacaa     2520

agccaagcga agcgatgagc tgagcttctg ccgtggtgcc ctcatccaca atgtctccaa     2580

ggagcccggg ggctggtgga aaggagacta tggaaccagg atccagcagt acttcccatc     2640

caactacgtc gaggacatct caactgcaga cttcgaggag ctagaaaagc agattattga     2700

agacaatccc ttagggtctc tttgcagagg aatattggac ctcaatacct ataacgtcgt     2760

gaaagcccct cagggaaaaa accagaagtc ctttgtcttc atcctggagc ccaagcagca     2820

gggcgatcct ccggtggagt ttgccacaga cagggtggag gagctctttg agtggtttca     2880

gagcatccga gagatcacct ggaagattga caccaaggag aacaacatga agtactggga     2940

gaagaaccag tccatcgcca tcgagctctc tgacctggtt gtctactgca aaccaaccag     3000

caaaaccaag gacaacttag aaaatcctga cttccgagaa atccgctcct ttgtggagac     3060

gaaggctgac agcatcatca gacagaagcc cgtcgacctc ctgaagtaca atcaaaaggg     3120

cctgacccgc gtctacccaa agggacaaag agttgactct tcaaactacg accccttccg     3180

cctctggctg tgcggttctc agatggtggc actcaatttc cagacggcag ataagtacat     3240

gcagatgaat cacgcattgt tttctctcaa tgggcgcacg ggctacgttc tgcagcctga     3300

gagcatgagg acagagaaat atgacccgat gccacccgag tcccagagga agatcctgat     3360

gacgctgaca gtcaaggttc tcggtgctcg ccatctcccc aaacttggac gaagtattgc     3420

ctgtcccttt gtagaagtgg agatctgtgg agccgagtat gacaacaaca agttcaagac     3480

gacggttgtg aatgataatg gcctcagccc tatctgggct ccaacacagg agaaggtgac     3540

atttgaaatt tatgacccaa acctggcatt tctgcgcttt gtggtttatg aagaagatat     3600

gttcagcgat cccaactttc ttgctcatgc cacttacccc attaaagcag tcaaatcagg     3660

attcaggtcc gttcctctga agaatgggta cagcgaggac atagagctgg cttccctcct     3720

ggttttctgt gagatgcggc cagtcctgga gagcgaagag gaactttact cctcctgtcg     3780

ccagctgagg aggcggcaag aagaactgaa caaccagctc tttctgtatg acacacacca     3840

gaacttgcgc aatgccaacc gggatgccct ggttaaagag ttcagtgtta atgagaacca     3900

gctccagctg taccaggaga aatgcaacaa gaggttaaga gagaagagag tcagcaacag     3960

caagttttac tcatagaagc tggggtatgt gtgtaagggt attgtgtgtg tgcgcatgtg     4020

tgtttgcatg taggagaacg tgccctattc acactctggg aagacgctaa tctgtgacat     4080

cttttcttca agcctgccat caaggacatt tcttaagacc caactggcat gagttggggt     4140

aatttcctat tattttcatc ttggacaact ttcttaactt atattcttta tagaggattc     4200

cccaaaatgt gctcctcatt tttggcctct catgttccaa acctcattga ataaaagcaa     4260

tgaaaacctt gaaaaaaaaa aaaaaaaaa                                       4289


<210>  2
<211>  1265
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1265)
<223>  PLCgamma2

<400>  2

Met Ser Thr Thr Val Asn Val Asp Ser Leu Ala Glu Tyr Glu Lys Ser 
1               5                   10                  15      


Gln Ile Lys Arg Ala Leu Glu Leu Gly Thr Val Met Thr Val Phe Ser 
            20                  25                  30          


Phe Arg Lys Ser Thr Pro Glu Arg Arg Thr Val Gln Val Ile Met Glu 
        35                  40                  45              


Thr Arg Gln Val Ala Trp Ser Lys Thr Ala Asp Lys Ile Glu Gly Phe 
    50                  55                  60                  


Leu Asp Ile Met Glu Ile Lys Glu Ile Arg Pro Gly Lys Asn Ser Lys 
65                  70                  75                  80  


Asp Phe Glu Arg Ala Lys Ala Val Arg Gln Lys Glu Asp Cys Cys Phe 
                85                  90                  95      


Thr Ile Leu Tyr Gly Thr Gln Phe Val Leu Ser Thr Leu Ser Leu Ala 
            100                 105                 110         


Ala Asp Ser Lys Glu Asp Ala Val Asn Trp Leu Ser Gly Leu Lys Ile 
        115                 120                 125             


Leu His Gln Glu Ala Met Asn Ala Ser Thr Pro Thr Ile Ile Glu Ser 
    130                 135                 140                 


Trp Leu Arg Lys Gln Ile Tyr Ser Val Asp Gln Thr Arg Arg Asn Ser 
145                 150                 155                 160 


Ile Ser Leu Arg Glu Leu Lys Thr Ile Leu Pro Leu Ile Asn Phe Lys 
                165                 170                 175     


Val Ser Ser Ala Lys Phe Leu Lys Asp Lys Phe Val Glu Ile Gly Ala 
            180                 185                 190         


His Lys Asp Glu Leu Ser Phe Glu Gln Phe His Leu Phe Tyr Lys Lys 
        195                 200                 205             


Leu Met Phe Glu Gln Gln Lys Ser Ile Leu Asp Glu Phe Lys Lys Asp 
    210                 215                 220                 


Ser Ser Val Phe Ile Leu Gly Asn Thr Asp Arg Pro Asp Ala Ser Ala 
225                 230                 235                 240 


Val Tyr Leu His Asp Phe Gln Arg Phe Leu Ile His Glu Gln Gln Glu 
                245                 250                 255     


His Trp Ala Gln Asp Leu Asn Lys Val Arg Glu Arg Met Thr Lys Phe 
            260                 265                 270         


Ile Asp Asp Thr Met Arg Glu Thr Ala Glu Pro Phe Leu Phe Val Asp 
        275                 280                 285             


Glu Phe Leu Thr Tyr Leu Phe Ser Arg Glu Asn Ser Ile Trp Asp Glu 
    290                 295                 300                 


Lys Tyr Asp Ala Val Asp Met Gln Asp Met Asn Asn Pro Leu Ser His 
305                 310                 315                 320 


Tyr Trp Ile Ser Ser Ser His Asn Thr Tyr Leu Thr Gly Asp Gln Leu 
                325                 330                 335     


Arg Ser Glu Ser Ser Pro Glu Ala Tyr Ile Arg Cys Leu Arg Met Gly 
            340                 345                 350         


Cys Arg Cys Ile Glu Leu Asp Cys Trp Asp Gly Pro Asp Gly Lys Pro 
        355                 360                 365             


Val Ile Tyr His Gly Trp Thr Arg Thr Thr Lys Ile Lys Phe Asp Asp 
    370                 375                 380                 


Val Val Gln Ala Ile Lys Asp His Ala Phe Val Thr Ser Ser Phe Pro 
385                 390                 395                 400 


Val Ile Leu Ser Ile Glu Glu His Cys Ser Val Glu Gln Gln Arg His 
                405                 410                 415     


Met Ala Lys Ala Phe Lys Glu Val Phe Gly Asp Leu Leu Leu Thr Lys 
            420                 425                 430         


Pro Thr Glu Ala Ser Ala Asp Gln Leu Pro Ser Pro Ser Gln Leu Arg 
        435                 440                 445             


Glu Lys Ile Ile Ile Lys His Lys Lys Leu Gly Pro Arg Gly Asp Val 
    450                 455                 460                 


Asp Val Asn Met Glu Asp Lys Lys Asp Glu His Lys Gln Gln Gly Glu 
465                 470                 475                 480 


Leu Tyr Met Trp Asp Ser Ile Asp Gln Lys Trp Thr Arg His Tyr Cys 
                485                 490                 495     


Ala Ile Ala Asp Ala Lys Leu Ser Phe Ser Asp Asp Ile Glu Gln Thr 
            500                 505                 510         


Met Glu Glu Glu Val Pro Gln Asp Ile Pro Pro Thr Glu Leu His Phe 
        515                 520                 525             


Gly Glu Lys Trp Phe His Lys Lys Val Glu Lys Arg Thr Ser Ala Glu 
    530                 535                 540                 


Lys Leu Leu Gln Glu Tyr Cys Met Glu Thr Gly Gly Lys Asp Gly Thr 
545                 550                 555                 560 


Phe Leu Val Arg Glu Ser Glu Thr Phe Pro Asn Asp Tyr Thr Leu Ser 
                565                 570                 575     


Phe Trp Arg Ser Gly Arg Val Gln His Cys Arg Ile Arg Ser Thr Met 
            580                 585                 590         


Glu Gly Gly Thr Leu Lys Tyr Tyr Leu Thr Asp Asn Leu Thr Phe Ser 
        595                 600                 605             


Ser Ile Tyr Ala Leu Ile Gln His Tyr Arg Glu Thr His Leu Arg Cys 
    610                 615                 620                 


Ala Glu Phe Glu Leu Arg Leu Thr Asp Pro Val Pro Asn Pro Asn Pro 
625                 630                 635                 640 


His Glu Ser Lys Pro Trp Tyr Tyr Asp Ser Leu Ser Arg Gly Glu Ala 
                645                 650                 655     


Glu Asp Met Leu Met Arg Ile Pro Arg Asp Gly Ala Phe Leu Ile Arg 
            660                 665                 670         


Lys Arg Glu Gly Ser Asp Ser Tyr Ala Ile Thr Phe Arg Ala Arg Gly 
        675                 680                 685             


Lys Val Lys His Cys Arg Ile Asn Arg Asp Gly Arg His Phe Val Leu 
    690                 695                 700                 


Gly Thr Ser Ala Tyr Phe Glu Ser Leu Val Glu Leu Val Ser Tyr Tyr 
705                 710                 715                 720 


Glu Lys His Ser Leu Tyr Arg Lys Met Arg Leu Arg Tyr Pro Val Thr 
                725                 730                 735     


Pro Glu Leu Leu Glu Arg Tyr Asn Met Glu Arg Asp Ile Asn Ser Leu 
            740                 745                 750         


Tyr Asp Val Ser Arg Met Tyr Val Asp Pro Ser Glu Ile Asn Pro Ser 
        755                 760                 765             


Met Pro Gln Arg Thr Val Lys Ala Leu Tyr Asp Tyr Lys Ala Lys Arg 
    770                 775                 780                 


Ser Asp Glu Leu Ser Phe Cys Arg Gly Ala Leu Ile His Asn Val Ser 
785                 790                 795                 800 


Lys Glu Pro Gly Gly Trp Trp Lys Gly Asp Tyr Gly Thr Arg Ile Gln 
                805                 810                 815     


Gln Tyr Phe Pro Ser Asn Tyr Val Glu Asp Ile Ser Thr Ala Asp Phe 
            820                 825                 830         


Glu Glu Leu Glu Lys Gln Ile Ile Glu Asp Asn Pro Leu Gly Ser Leu 
        835                 840                 845             


Cys Arg Gly Ile Leu Asp Leu Asn Thr Tyr Asn Val Val Lys Ala Pro 
    850                 855                 860                 


Gln Gly Lys Asn Gln Lys Ser Phe Val Phe Ile Leu Glu Pro Lys Gln 
865                 870                 875                 880 


Gln Gly Asp Pro Pro Val Glu Phe Ala Thr Asp Arg Val Glu Glu Leu 
                885                 890                 895     


Phe Glu Trp Phe Gln Ser Ile Arg Glu Ile Thr Trp Lys Ile Asp Thr 
            900                 905                 910         


Lys Glu Asn Asn Met Lys Tyr Trp Glu Lys Asn Gln Ser Ile Ala Ile 
        915                 920                 925             


Glu Leu Ser Asp Leu Val Val Tyr Cys Lys Pro Thr Ser Lys Thr Lys 
    930                 935                 940                 


Asp Asn Leu Glu Asn Pro Asp Phe Arg Glu Ile Arg Ser Phe Val Glu 
945                 950                 955                 960 


Thr Lys Ala Asp Ser Ile Ile Arg Gln Lys Pro Val Asp Leu Leu Lys 
                965                 970                 975     


Tyr Asn Gln Lys Gly Leu Thr Arg Val Tyr Pro Lys Gly Gln Arg Val 
            980                 985                 990         


Asp Ser Ser Asn Tyr Asp Pro Phe  Arg Leu Trp Leu Cys  Gly Ser Gln 
        995                 1000                 1005             


Met Val  Ala Leu Asn Phe Gln  Thr Ala Asp Lys Tyr  Met Gln Met 
    1010                 1015                 1020             


Asn His  Ala Leu Phe Ser Leu  Asn Gly Arg Thr Gly  Tyr Val Leu 
    1025                 1030                 1035             


Gln Pro  Glu Ser Met Arg Thr  Glu Lys Tyr Asp Pro  Met Pro Pro 
    1040                 1045                 1050             


Glu Ser  Gln Arg Lys Ile Leu  Met Thr Leu Thr Val  Lys Val Leu 
    1055                 1060                 1065             


Gly Ala  Arg His Leu Pro Lys  Leu Gly Arg Ser Ile  Ala Cys Pro 
    1070                 1075                 1080             


Phe Val  Glu Val Glu Ile Cys  Gly Ala Glu Tyr Asp  Asn Asn Lys 
    1085                 1090                 1095             


Phe Lys  Thr Thr Val Val Asn  Asp Asn Gly Leu Ser  Pro Ile Trp 
    1100                 1105                 1110             


Ala Pro  Thr Gln Glu Lys Val  Thr Phe Glu Ile Tyr  Asp Pro Asn 
    1115                 1120                 1125             


Leu Ala  Phe Leu Arg Phe Val  Val Tyr Glu Glu Asp  Met Phe Ser 
    1130                 1135                 1140             


Asp Pro  Asn Phe Leu Ala His  Ala Thr Tyr Pro Ile  Lys Ala Val 
    1145                 1150                 1155             


Lys Ser  Gly Phe Arg Ser Val  Pro Leu Lys Asn Gly  Tyr Ser Glu 
    1160                 1165                 1170             


Asp Ile  Glu Leu Ala Ser Leu  Leu Val Phe Cys Glu  Met Arg Pro 
    1175                 1180                 1185             


Val Leu  Glu Ser Glu Glu Glu  Leu Tyr Ser Ser Cys  Arg Gln Leu 
    1190                 1195                 1200             


Arg Arg  Arg Gln Glu Glu Leu  Asn Asn Gln Leu Phe  Leu Tyr Asp 
    1205                 1210                 1215             


Thr His  Gln Asn Leu Arg Asn  Ala Asn Arg Asp Ala  Leu Val Lys 
    1220                 1225                 1230             


Glu Phe  Ser Val Asn Glu Asn  Gln Leu Gln Leu Tyr  Gln Glu Lys 
    1235                 1240                 1245             


Cys Asn  Lys Arg Leu Arg Glu  Lys Arg Val Ser Asn  Ser Lys Phe 
    1250                 1255                 1260             


Tyr Ser  
    1265 


