                         SEQUENCE LISTING

<110>  University of Massachusetts
Mueller, Christian
Brown, Robert
 
<120>  RAAV-BASED COMPOSITIONS AND METHODS FOR TREATING AMYOTROPHIC 
       LATERAL SCLEROSIS

<130>  U0120.70061WO00

<150>  US 61/955,189
<151>  2014-03-18

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  1
tttggagccc aaatgtgcct t                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  2
tatagcacca ctctctgcat t                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  3
tatagcacca ctctctgcta a                                                 21


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  4
tttacatcta tagcaccact c                                                 21


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  5
aatactctga ccctgatctt c                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  6
tgacgcacct ctctttccta g                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  7
tttacgtggg cggaacttgt c                                                 21


<210>  8
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  8
tagatatcaa gcgtcatctt t                                                 21


<210>  9
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  9
acgtaaccta cggtgtccc                                                    19


<210>  10
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  10
tgcggttgcg gtgcct                                                       16


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  11
ctcatgacca cagtccatgc                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  12
ctacaggctg cggttgtttc                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  13
ccaccagtcg ctagaggcga                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  14
atgaccttgc ccacagcctt                                                   20


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  15
agcattaaag gactgactga a                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  16
gactgaaggc ctgcatggat t                                                 21


<210>  17
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223> Synthetic nucleic acid

<400>  17
ctgcatggat tccatgttca t                                                 21


<210>  18
<211>  1957
<212>  DNA
<213>  Homo sapiens

<400>  18
acgtaaccta cggtgtcccg ctaggaaaga gaggtgcgtc aaacagcgac aagttccgcc       60

cacgtaaaag atgacgcttg atatctccgg agcatttgga taatgtgaca gttggaatgc      120

agtgatgtcg actctttgcc caccgccatc tccagctgtt gccaagacag agattgcttt      180

aagtggcaaa tcacctttat tagcagctac ttttgcttac tgggacaata ttcttggtcc      240

tagagtaagg cacatttggg ctccaaagac agaacaggta cttctcagtg atggagaaat      300

aacttttctt gccaaccaca ctctaaatgg agaaatcctt cgaaatgcag agagtggtgc      360

tatagatgta aagttttttg tcttgtctga aaagggagtg attattgttt cattaatctt      420

tgatggaaac tggaatgggg atcgcagcac atatggacta tcaattatac ttccacagac      480

agaacttagt ttctacctcc cacttcatag agtgtgtgtt gatagattaa cacatataat      540

ccggaaagga agaatatgga tgcataagga aagacaagaa aatgtccaga agattatctt      600

agaaggcaca gagagaatgg aagatcaggg tcagagtatt attccaatgc ttactggaga      660

agtgattcct gtaatggaac tgctttcatc tatgaaatca cacagtgttc ctgaagaaat      720

agatatagct gatacagtac tcaatgatga tgatattggt gacagctgtc atgaaggctt      780

tcttctcaag taagaatttt tcttttcata aaagctggat gaagcagata ccatcttatg      840

ctcacctatg acaagatttg gaagaaagaa aataacagac tgtctactta gattgttcta      900

gggacattac gtatttgaac tgttgcttaa atttgtgtta tttttcactc attatatttc      960

tatatatatt tggtgttatt ccatttgcta tttaaagaaa ccgagtttcc atcccagaca     1020

agaaatcatg gccccttgct tgattctggt ttcttgtttt acttctcatt aaagctaaca     1080

gaatcctttc atattaagtt gtactgtaga tgaacttaag ttatttaggc gtagaacaaa     1140

attattcata tttatactga tctttttcca tccagcagtg gagtttagta cttaagagtt     1200

tgtgccctta aaccagactc cctggattaa tgctgtgtac ccgtgggcaa ggtgcctgaa     1260

ttctctatac acctatttcc tcatctgtaa aatggcaata atagtaatag tacctaatgt     1320

gtagggttgt tataagcatt gagtaagata aataatataa agcacttaga acagtgcctg     1380

gaacataaaa acacttaata atagctcata gctaacattt cctatttaca tttcttctag     1440

aaatagccag tatttgttga gtgcctacat gttagttcct ttactagttg ctttacatgt     1500

attatcttat attctgtttt aaagtttctt cacagttaca gattttcatg aaattttact     1560

tttaataaaa gagaagtaaa agtataaagt attcactttt atgttcacag tcttttcctt     1620

taggctcatg atggagtatc agaggcatga gtgtgtttaa cctaagagcc ttaatggctt     1680

gaatcagaag cactttagtc ctgtatctgt tcagtgtcag cctttcatac atcattttaa     1740

atcccatttg actttaagta agtcacttaa tctctctaca tgtcaatttc ttcagctata     1800

aaatgatggt atttcaataa ataaatacat taattaaatg atattatact gactaattgg     1860

gctgttttaa ggctcaataa gaaaatttct gtgaaaggtc tctagaaaat gtaggttcct     1920

atacaaataa aagataacat tgtgcttata aaaaaaa                              1957


<210>  19
<211>  3244
<212>  DNA
<213>  Homo sapiens

<400>  19
gggcggggct gcggttgcgg tgcctgcgcc cgcggcggcg gaggcgcagg cggtggcgag       60

tggatatctc cggagcattt ggataatgtg acagttggaa tgcagtgatg tcgactcttt      120

gcccaccgcc atctccagct gttgccaaga cagagattgc tttaagtggc aaatcacctt      180

tattagcagc tacttttgct tactgggaca atattcttgg tcctagagta aggcacattt      240

gggctccaaa gacagaacag gtacttctca gtgatggaga aataactttt cttgccaacc      300

acactctaaa tggagaaatc cttcgaaatg cagagagtgg tgctatagat gtaaagtttt      360

ttgtcttgtc tgaaaaggga gtgattattg tttcattaat ctttgatgga aactggaatg      420

gggatcgcag cacatatgga ctatcaatta tacttccaca gacagaactt agtttctacc      480

tcccacttca tagagtgtgt gttgatagat taacacatat aatccggaaa ggaagaatat      540

ggatgcataa ggaaagacaa gaaaatgtcc agaagattat cttagaaggc acagagagaa      600

tggaagatca gggtcagagt attattccaa tgcttactgg agaagtgatt cctgtaatgg      660

aactgctttc atctatgaaa tcacacagtg ttcctgaaga aatagatata gctgatacag      720

tactcaatga tgatgatatt ggtgacagct gtcatgaagg ctttcttctc aatgccatca      780

gctcacactt gcaaacctgt ggctgttccg ttgtagtagg tagcagtgca gagaaagtaa      840

ataagatagt cagaacatta tgcctttttc tgactccagc agagagaaaa tgctccaggt      900

tatgtgaagc agaatcatca tttaaatatg agtcagggct ctttgtacaa ggcctgctaa      960

aggattcaac tggaagcttt gtgctgcctt tccggcaagt catgtatgct ccatatccca     1020

ccacacacat agatgtggat gtcaatactg tgaagcagat gccaccctgt catgaacata     1080

tttataatca gcgtagatac atgagatccg agctgacagc cttctggaga gccacttcag     1140

aagaagacat ggctcaggat acgatcatct acactgacga aagctttact cctgatttga     1200

atatttttca agatgtctta cacagagaca ctctagtgaa agccttcctg gatcaggtct     1260

ttcagctgaa acctggctta tctctcagaa gtactttcct tgcacagttt ctacttgtcc     1320

ttcacagaaa agccttgaca ctaataaaat atatagaaga cgatacgcag aagggaaaaa     1380

agccctttaa atctcttcgg aacctgaaga tagaccttga tttaacagca gagggcgatc     1440

ttaacataat aatggctctg gctgagaaaa ttaaaccagg cctacactct tttatctttg     1500

gaagaccttt ctacactagt gtgcaagaac gagatgttct aatgactttt taaatgtgta     1560

acttaataag cctattccat cacaatcatg atcgctggta aagtagctca gtggtgtggg     1620

gaaacgttcc cctggatcat actccagaat tctgctctca gcaattgcag ttaagtaagt     1680

tacactacag ttctcacaag agcctgtgag gggatgtcag gtgcatcatt acattgggtg     1740

tctcttttcc tagatttatg cttttgggat acagacctat gtttacaata taataaatat     1800

tattgctatc ttttaaagat ataataatag gatgtaaact tgaccacaac tactgttttt     1860

ttgaaataca tgattcatgg tttacatgtg tcaaggtgaa atctgagttg gcttttacag     1920

atagttgact ttctatcttt tggcattctt tggtgtgtag aattactgta atacttctgc     1980

aatcaactga aaactagagc ctttaaatga tttcaattcc acagaaagaa agtgagcttg     2040

aacataggat gagctttaga aagaaaattg atcaagcaga tgtttaattg gaattgatta     2100

ttagatccta ctttgtggat ttagtccctg ggattcagtc tgtagaaatg tctaatagtt     2160

ctctatagtc cttgttcctg gtgaaccaca gttagggtgt tttgtttatt ttattgttct     2220

tgctattgtt gatattctat gtagttgagc tctgtaaaag gaaattgtat tttatgtttt     2280

agtaattgtt gccaactttt taaattaatt ttcattattt ttgagccaaa ttgaaatgtg     2340

cacctcctgt gccttttttc tccttagaaa atctaattac ttggaacaag ttcagatttc     2400

actggtcagt cattttcatc ttgttttctt cttgctaagt cttaccatgt acctgctttg     2460

gcaatcattg caactctgag attataaaat gccttagaga atatactaac taataagatc     2520

tttttttcag aaacagaaaa tagttccttg agtacttcct tcttgcattt ctgcctatgt     2580

ttttgaagtt gttgctgttt gcctgcaata ggctataagg aatagcagga gaaattttac     2640

tgaagtgctg ttttcctagg tgctactttg gcagagctaa gttatctttt gttttcttaa     2700

tgcgtttgga ccattttgct ggctataaaa taactgatta atataattct aacacaatgt     2760

tgacattgta gttacacaaa cacaaataaa tattttattt aaaattctgg aagtaatata     2820

aaagggaaaa tatatttata agaaagggat aaaggtaata gagcccttct gccccccacc     2880

caccaaattt acacaacaaa atgacatgtt cgaatgtgaa aggtcataat agctttccca     2940

tcatgaatca gaaagatgtg gacagcttga tgttttagac aaccactgaa ctagatgact     3000

gttgtactgt agctcagtca tttaaaaaat atataaatac taccttgtag tgtcccatac     3060

tgtgtttttt acatggtaga ttcttattta agtgctaact ggttattttc tttggctggt     3120

ttattgtact gttatacaga atgtaagttg tacagtgaaa taagttatta aagcatgtgt     3180

aaacattgtt atatatcttt tctcctaaat ggagaatttt gaataaaata tatttgaaat     3240

tttg                                                                  3244


<210>  20
<211>  3339
<212>  DNA
<213>  Homo sapiens

<400>  20
acgtaaccta cggtgtcccg ctaggaaaga gaggtgcgtc aaacagcgac aagttccgcc       60

cacgtaaaag atgacgcttg gtgtgtcagc cgtccctgct gcccggttgc ttctcttttg      120

ggggcggggt ctagcaagag caggtgtggg tttaggagat atctccggag catttggata      180

atgtgacagt tggaatgcag tgatgtcgac tctttgccca ccgccatctc cagctgttgc      240

caagacagag attgctttaa gtggcaaatc acctttatta gcagctactt ttgcttactg      300

ggacaatatt cttggtccta gagtaaggca catttgggct ccaaagacag aacaggtact      360

tctcagtgat ggagaaataa cttttcttgc caaccacact ctaaatggag aaatccttcg      420

aaatgcagag agtggtgcta tagatgtaaa gttttttgtc ttgtctgaaa agggagtgat      480

tattgtttca ttaatctttg atggaaactg gaatggggat cgcagcacat atggactatc      540

aattatactt ccacagacag aacttagttt ctacctccca cttcatagag tgtgtgttga      600

tagattaaca catataatcc ggaaaggaag aatatggatg cataaggaaa gacaagaaaa      660

tgtccagaag attatcttag aaggcacaga gagaatggaa gatcagggtc agagtattat      720

tccaatgctt actggagaag tgattcctgt aatggaactg ctttcatcta tgaaatcaca      780

cagtgttcct gaagaaatag atatagctga tacagtactc aatgatgatg atattggtga      840

cagctgtcat gaaggctttc ttctcaatgc catcagctca cacttgcaaa cctgtggctg      900

ttccgttgta gtaggtagca gtgcagagaa agtaaataag atagtcagaa cattatgcct      960

ttttctgact ccagcagaga gaaaatgctc caggttatgt gaagcagaat catcatttaa     1020

atatgagtca gggctctttg tacaaggcct gctaaaggat tcaactggaa gctttgtgct     1080

gcctttccgg caagtcatgt atgctccata tcccaccaca cacatagatg tggatgtcaa     1140

tactgtgaag cagatgccac cctgtcatga acatatttat aatcagcgta gatacatgag     1200

atccgagctg acagccttct ggagagccac ttcagaagaa gacatggctc aggatacgat     1260

catctacact gacgaaagct ttactcctga tttgaatatt tttcaagatg tcttacacag     1320

agacactcta gtgaaagcct tcctggatca ggtctttcag ctgaaacctg gcttatctct     1380

cagaagtact ttccttgcac agtttctact tgtccttcac agaaaagcct tgacactaat     1440

aaaatatata gaagacgata cgcagaaggg aaaaaagccc tttaaatctc ttcggaacct     1500

gaagatagac cttgatttaa cagcagaggg cgatcttaac ataataatgg ctctggctga     1560

gaaaattaaa ccaggcctac actcttttat ctttggaaga cctttctaca ctagtgtgca     1620

agaacgagat gttctaatga ctttttaaat gtgtaactta ataagcctat tccatcacaa     1680

tcatgatcgc tggtaaagta gctcagtggt gtggggaaac gttcccctgg atcatactcc     1740

agaattctgc tctcagcaat tgcagttaag taagttacac tacagttctc acaagagcct     1800

gtgaggggat gtcaggtgca tcattacatt gggtgtctct tttcctagat ttatgctttt     1860

gggatacaga cctatgttta caatataata aatattattg ctatctttta aagatataat     1920

aataggatgt aaacttgacc acaactactg tttttttgaa atacatgatt catggtttac     1980

atgtgtcaag gtgaaatctg agttggcttt tacagatagt tgactttcta tcttttggca     2040

ttctttggtg tgtagaatta ctgtaatact tctgcaatca actgaaaact agagccttta     2100

aatgatttca attccacaga aagaaagtga gcttgaacat aggatgagct ttagaaagaa     2160

aattgatcaa gcagatgttt aattggaatt gattattaga tcctactttg tggatttagt     2220

ccctgggatt cagtctgtag aaatgtctaa tagttctcta tagtccttgt tcctggtgaa     2280

ccacagttag ggtgttttgt ttattttatt gttcttgcta ttgttgatat tctatgtagt     2340

tgagctctgt aaaaggaaat tgtattttat gttttagtaa ttgttgccaa ctttttaaat     2400

taattttcat tatttttgag ccaaattgaa atgtgcacct cctgtgcctt ttttctcctt     2460

agaaaatcta attacttgga acaagttcag atttcactgg tcagtcattt tcatcttgtt     2520

ttcttcttgc taagtcttac catgtacctg ctttggcaat cattgcaact ctgagattat     2580

aaaatgcctt agagaatata ctaactaata agatcttttt ttcagaaaca gaaaatagtt     2640

ccttgagtac ttccttcttg catttctgcc tatgtttttg aagttgttgc tgtttgcctg     2700

caataggcta taaggaatag caggagaaat tttactgaag tgctgttttc ctaggtgcta     2760

ctttggcaga gctaagttat cttttgtttt cttaatgcgt ttggaccatt ttgctggcta     2820

taaaataact gattaatata attctaacac aatgttgaca ttgtagttac acaaacacaa     2880

ataaatattt tatttaaaat tctggaagta atataaaagg gaaaatatat ttataagaaa     2940

gggataaagg taatagagcc cttctgcccc ccacccacca aatttacaca acaaaatgac     3000

atgttcgaat gtgaaaggtc ataatagctt tcccatcatg aatcagaaag atgtggacag     3060

cttgatgttt tagacaacca ctgaactaga tgactgttgt actgtagctc agtcatttaa     3120

aaaatatata aatactacct tgtagtgtcc catactgtgt tttttacatg gtagattctt     3180

atttaagtgc taactggtta ttttctttgg ctggtttatt gtactgttat acagaatgta     3240

agttgtacag tgaaataagt tattaaagca tgtgtaaaca ttgttatata tcttttctcc     3300

taaatggaga attttgaata aaatatattt gaaattttg                            3339


