                         SEQUENCE LISTING

<110>  TDW Group
       
 
<120>  ENGINEERED CHIMERIC PEGYLATED ADI AND METHODS OF USE

<130>  TDWG-002/01WO

<150>  US 61/954,929
<151>  2014-03-18

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  409
<212>  PRT
<213>  Mycoplasma hominis

<400>  1

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Ser Phe Val Lys Ile 
    50                  55                  60                  


Met Lys Asp Arg Gly Ile Asn Val Val Glu Leu Thr Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Lys Ala Ala Lys Glu Glu Phe Ile Glu 
                85                  90                  95      


Thr Phe Leu Glu Glu Thr Val Pro Val Leu Thr Glu Ala Asn Lys Lys 
            100                 105                 110         


Ala Val Arg Ala Phe Leu Leu Ser Lys Pro Thr His Glu Met Val Glu 
        115                 120                 125             


Phe Met Met Ser Gly Ile Thr Lys Tyr Glu Leu Gly Val Glu Ser Glu 
    130                 135                 140                 


Asn Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp 
145                 150                 155                 160 


Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Phe Met Arg Tyr 
                165                 170                 175     


Ile Val Arg Arg Arg Glu Thr Leu Phe Ala Arg Phe Val Phe Arg Asn 
            180                 185                 190         


His Pro Lys Leu Val Lys Thr Pro Trp Tyr Tyr Asp Pro Ala Met Lys 
        195                 200                 205             


Met Pro Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Glu Thr Leu 
    210                 215                 220                 


Val Val Gly Val Ser Glu Arg Thr Asp Leu Asp Thr Ile Thr Leu Leu 
225                 230                 235                 240 


Ala Lys Asn Ile Lys Ala Asn Lys Glu Val Glu Phe Lys Arg Ile Val 
                245                 250                 255     


Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr Trp 
            260                 265                 270         


Leu Thr Met Leu Asp Lys Asn Lys Phe Leu Tyr Ser Pro Ile Ala Asn 
        275                 280                 285             


Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala Glu 
    290                 295                 300                 


Pro Gln Pro Gln Leu Asn Gly Leu Pro Leu Asp Lys Leu Leu Ala Ser 
305                 310                 315                 320 


Ile Ile Asn Lys Glu Pro Val Leu Ile Pro Ile Gly Gly Ala Gly Ala 
                325                 330                 335     


Thr Glu Met Glu Ile Ala Arg Glu Thr Asn Phe Asp Gly Thr Asn Tyr 
            340                 345                 350         


Leu Ala Ile Lys Pro Gly Leu Val Ile Gly Tyr Asp Arg Asn Glu Lys 
        355                 360                 365             


Thr Asn Ala Ala Leu Lys Ala Ala Gly Ile Thr Val Leu Pro Phe His 
    370                 375                 380                 


Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser Met 
385                 390                 395                 400 


Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 


<210>  2
<211>  410
<212>  PRT
<213>  Mycoplasma arginini

<400>  2

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Ile Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His Lys Val 
            100                 105                 110         


Val Val Arg Asn Phe Leu Lys Ala Lys Lys Thr Ser Arg Glu Leu Val 
        115                 120                 125             


Glu Ile Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Ser Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  3
<211>  410
<212>  PRT
<213>  Mycoplasma arthritidis

<400>  3

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Lys Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Glu Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Lys Arg Gly Ile Asn Val Val Glu Leu Val Asp Leu Ile Val 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Lys Glu Ala Lys Glu Lys Leu Leu Glu 
                85                  90                  95      


Glu Phe Leu Asp Asp Ser Val Pro Val Leu Ser Asp Glu His Arg Ala 
            100                 105                 110         


Thr Val Lys Lys Phe Leu Gln Ser Gln Lys Ser Thr Arg Ser Leu Val 
        115                 120                 125             


Glu Tyr Met Ile Ala Gly Ile Thr Lys His Asp Leu Lys Ile Glu Ser 
    130                 135                 140                 


Asp Leu Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Val Asn Thr Pro Trp Tyr Tyr Asp Pro Ala Glu 
        195                 200                 205             


Gly Leu Thr Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Ile Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Ser Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Asp 
    290                 295                 300                 


Ala Pro Gln Pro Val Asp Asn Gly Leu Pro Leu Glu Asp Leu Leu Lys 
305                 310                 315                 320 


Ser Ile Ile Gly Lys Lys Pro Thr Leu Ile Pro Ile Ala Gly Ala Gly 
                325                 330                 335     


Ala Ser Gln Ile Asp Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Val Ala Pro Gly Ile Val Ile Gly Tyr Ala Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Thr Val Leu Pro Phe 
    370                 375                 380                 


Arg Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  4
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS1 recombinant chimeric ADI protein

<400>  4

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Val Asp Leu Ile Val 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Lys Glu Ala Lys Glu Lys Leu Leu Glu 
                85                  90                  95      


Glu Phe Leu Asp Asp Ser Val Pro Val Leu Ser Asp Glu His Arg Ala 
            100                 105                 110         


Thr Val Lys Lys Phe Leu Gln Ser Gln Lys Ser Thr Arg Ser Leu Val 
        115                 120                 125             


Glu Tyr Met Ile Ala Gly Ile Thr Lys His Asp Leu Lys Ile Glu Ser 
    130                 135                 140                 


Asp Leu Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Ser Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  5
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS2 recombinant chimeric ADI protein

<400>  5

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Thr Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Arg Ala Ala Lys Glu Glu Phe Ile Glu 
                85                  90                  95      


Thr Phe Leu Glu Glu Thr Val Pro Val Leu Thr Glu Ala Asn Arg Glu 
            100                 105                 110         


Ala Val Arg Ala Phe Leu Leu Ser Lys Pro Thr His Glu Met Val Glu 
        115                 120                 125             


Phe Met Met Ser Gly Ile Thr Lys Tyr Glu Leu Gly Val Glu Ser Glu 
    130                 135                 140                 


Asn Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp 
145                 150                 155                 160 


Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg Tyr 
                165                 170                 175     


Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser Asn 
            180                 185                 190         


His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu Lys 
        195                 200                 205             


Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr Leu 
    210                 215                 220                 


Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu Leu 
225                 230                 235                 240 


Ala Lys Asn Ile Val Ala Asn Lys Glu Ser Glu Phe Lys Arg Ile Val 
                245                 250                 255     


Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr Trp 
            260                 265                 270         


Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala Asn 
        275                 280                 285             


Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala Glu 
    290                 295                 300                 


Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln Ser 
305                 310                 315                 320 


Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Glu Gly Ala 
                325                 330                 335     


Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn Tyr 
            340                 345                 350         


Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu Lys 
        355                 360                 365             


Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe His 
    370                 375                 380                 


Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser Met 
385                 390                 395                 400 


Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 


<210>  6
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS3 recombinant chimeric ADI protein

<400>  6

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Lys Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Glu Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Lys Arg Gly Ile Asn Val Val Glu Leu Ile Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His Lys Val 
            100                 105                 110         


Val Val Arg Asn Phe Leu Lys Ala Lys Lys Thr Ser Arg Glu Leu Val 
        115                 120                 125             


Glu Ile Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Val Asn Thr Pro Trp Tyr Tyr Asp Pro Ala Glu 
        195                 200                 205             


Gly Leu Thr Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Ile Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Ser Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Asp 
    290                 295                 300                 


Ala Pro Gln Pro Val Asp Asn Gly Leu Pro Leu Glu Asp Leu Leu Lys 
305                 310                 315                 320 


Ser Ile Ile Gly Lys Lys Pro Thr Leu Ile Pro Ile Ala Gly Ala Gly 
                325                 330                 335     


Ala Ser Gln Ile Asp Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Val Ala Pro Gly Ile Val Ile Gly Tyr Ala Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Thr Val Leu Pro Phe 
    370                 375                 380                 


Arg Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  7
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS4 recombinant chimeric ADI protein

<400>  7

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Lys Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Glu Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Lys Arg Gly Ile Asn Val Val Glu Leu Thr Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Arg Ala Ala Lys Glu Glu Phe Ile Glu 
                85                  90                  95      


Thr Phe Leu Glu Glu Thr Val Pro Val Leu Thr Glu Ala Asn Arg Glu 
            100                 105                 110         


Ala Val Arg Ala Phe Leu Leu Ser Lys Pro Thr His Glu Met Val Glu 
        115                 120                 125             


Phe Met Met Ser Gly Ile Thr Lys Tyr Glu Leu Gly Val Glu Ser Glu 
    130                 135                 140                 


Asn Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp 
145                 150                 155                 160 


Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg Tyr 
                165                 170                 175     


Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser Asn 
            180                 185                 190         


His Pro Lys Leu Val Asn Thr Pro Trp Tyr Tyr Asp Pro Ala Glu Gly 
        195                 200                 205             


Leu Thr Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr Leu 
    210                 215                 220                 


Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Ile Thr Leu Leu 
225                 230                 235                 240 


Ala Lys Asn Ile Lys Ala Asn Lys Glu Ser Glu Phe Lys Arg Ile Val 
                245                 250                 255     


Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr Trp 
            260                 265                 270         


Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala Asn 
        275                 280                 285             


Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Asp Ala 
    290                 295                 300                 


Pro Gln Pro Val Asp Asn Gly Leu Pro Leu Glu Asp Leu Leu Lys Ser 
305                 310                 315                 320 


Ile Ile Gly Lys Lys Pro Thr Leu Ile Pro Ile Ala Gly Ala Gly Ala 
                325                 330                 335     


Ser Gln Ile Asp Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn Tyr 
            340                 345                 350         


Leu Ala Val Ala Pro Gly Ile Val Ile Gly Tyr Ala Arg Asn Glu Lys 
        355                 360                 365             


Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Thr Val Leu Pro Phe Arg 
    370                 375                 380                 


Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser Met 
385                 390                 395                 400 


Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 


<210>  8
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric ADI derived from M. hominis (catalytic 
       domain) and M. arginini (alpha-helical domain)

<400>  8

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Ser Phe Val Ala Ile 
    50                  55                  60                  


Met Lys Asp Arg Gly Ile Asn Val Val Glu Leu Ile Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His Lys Val 
            100                 105                 110         


Val Val Arg Asn Phe Leu Lys Ala Lys Lys Thr Ser Arg Glu Leu Val 
        115                 120                 125             


Glu Ile Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Phe Met Arg 
                165                 170                 175     


Tyr Ile Val Arg Arg Arg Glu Thr Leu Phe Ala Arg Phe Val Phe Arg 
            180                 185                 190         


Asn His Pro Lys Leu Val Asn Thr Pro Trp Tyr Tyr Asp Pro Ala Met 
        195                 200                 205             


Arg Met Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Glu Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Asp Thr Ile Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Val Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asn Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Gln Leu Asn Gly Leu Pro Leu Asp Arg Leu Leu Ala 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Glu Pro Val Leu Ile Pro Ile Gly Gly Ala Gly 
                325                 330                 335     


Ala Thr Glu Met Glu Ile Ala Arg Glu Thr Asn Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Leu Val Ile Gly Tyr Asp Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Thr Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  9
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  recombinant chimeric ADI derived from M. hominis (catalytic 
       domain) and M. arthritidis (alpha-helical domain)

<400>  9

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Ser Phe Val Ala Ile 
    50                  55                  60                  


Met Lys Asp Arg Gly Ile Asn Val Val Glu Leu Val Asp Leu Ile Val 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Lys Glu Ala Lys Glu Lys Leu Leu Glu 
                85                  90                  95      


Glu Phe Leu Asp Asp Ser Val Pro Val Leu Ser Asp Glu His Arg Ala 
            100                 105                 110         


Thr Val Lys Lys Phe Leu Gln Ser Gln Lys Ser Thr Arg Ser Leu Val 
        115                 120                 125             


Glu Tyr Met Ile Ala Gly Ile Thr Lys His Asp Leu Lys Ile Glu Ser 
    130                 135                 140                 


Asp Leu Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Phe Met Arg 
                165                 170                 175     


Tyr Ile Val Arg Arg Arg Glu Thr Leu Phe Ala Arg Phe Val Phe Arg 
            180                 185                 190         


Asn His Pro Lys Leu Val Asn Thr Pro Trp Tyr Tyr Asp Pro Ala Met 
        195                 200                 205             


Arg Met Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Glu Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Asp Thr Ile Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Val Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asn Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Gln Leu Asn Gly Leu Pro Leu Asp Arg Leu Leu Ala 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Glu Pro Val Leu Ile Pro Ile Gly Gly Ala Gly 
                325                 330                 335     


Ala Thr Glu Met Glu Ile Ala Arg Glu Thr Asn Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Leu Val Ile Gly Tyr Asp Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Thr Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  10
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS1-1 lysine reduction mutant of the recombinant chimeric ADI 
       protein

<400>  10

Met Ser Val Phe Asp Ser His Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Val Asp Leu Ile Val 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Arg Glu Ala Lys Glu Lys Leu Leu Glu 
                85                  90                  95      


Glu Phe Leu Asp Asp Ser Val Pro Val Leu Ser Asp Glu His Arg Ala 
            100                 105                 110         


Thr Val Lys Lys Phe Leu Gln Ser Gln Lys Ser Thr Arg Ser Leu Val 
        115                 120                 125             


Glu Tyr Met Ile Ala Gly Ile Thr Arg His Asp Leu Lys Ile Glu Ser 
    130                 135                 140                 


Asp Leu Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Arg Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Ser Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Thr Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  11
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS1-2 lysine reduction mutant of the recombinant chimeric ADI 
       protein

<400>  11

Met Ser Val Phe Asp Ser His Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Val Asp Leu Ile Val 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Arg Glu Ala Lys Glu Lys Leu Leu Glu 
                85                  90                  95      


Glu Phe Leu Asp Asp Ser Val Pro Val Leu Ser Asp Glu His Arg Ala 
            100                 105                 110         


Thr Val Arg Asn Phe Leu Gln Ser Gln Lys Ser Thr Arg Ser Leu Val 
        115                 120                 125             


Glu Tyr Met Ile Ala Gly Ile Thr Arg His Asp Leu Lys Ile Glu Ser 
    130                 135                 140                 


Asp Leu Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Ile Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Arg Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Ser Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Thr Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  12
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS1-3 lysine reduction mutant of the recombinant chimeric ADI 
       protein

<400>  12

Met Ser Val Phe Asp Ser His Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Arg Ala Asn Asp Ile Asn Val Val Glu Leu Val Asp Leu Ile Val 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Arg Glu Ala Gln Glu Asn Leu Leu Glu 
                85                  90                  95      


Glu Phe Leu Asp Asp Ser Val Pro Val Leu Ser Asp Glu His Arg Ala 
            100                 105                 110         


Thr Val Arg Asn Phe Leu Gln Ser Gln Lys Ser Thr Arg Ser Leu Val 
        115                 120                 125             


Glu Tyr Met Ile Ala Gly Ile Thr Arg His Asp Leu Gly Ile Glu Ser 
    130                 135                 140                 


Asp Leu Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Ile Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Arg Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Ser Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Arg Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Thr Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  13
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DS1-4 lysine reduction mutant of the recombinant chimeric ADI 
       protein

<400>  13

Met Ser Val Phe Asp Ser His Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Thr Glu His Gln Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Arg Ala Asn Asp Ile Asn Val Val Glu Leu Val Asp Leu Ile Val 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Arg Glu Ala Gln Glu Asn Leu Leu Glu 
                85                  90                  95      


Glu Phe Leu Asp Asp Ser Val Pro Val Leu Ser Asp Glu His Arg Ala 
            100                 105                 110         


Thr Val Arg Asn Phe Leu Gln Ser Gln Lys Ser Thr Arg Ser Leu Val 
        115                 120                 125             


Glu Tyr Met Ile Ala Gly Ile Thr Arg His Asp Leu Gly Ile Glu Ser 
    130                 135                 140                 


Asp Leu Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Ile Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Leu Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Arg Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Ser Glu Phe Arg Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Arg Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Arg Arg Pro Val Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Thr Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Arg Asp Val Lys Trp 
                405                 410 


<210>  14
<211>  409
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated M. hominis ADI sequence

<400>  14

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Ser Phe Val Lys Ile 
    50                  55                  60                  


Met Lys Asp Arg Gly Ile Asn Val Val Glu Leu Thr Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Lys Ala Ala Lys Glu Glu Phe Ile Glu 
                85                  90                  95      


Thr Phe Leu Glu Glu Thr Val Pro Val Leu Thr Glu Ala Asn Lys Glu 
            100                 105                 110         


Ala Val Arg Ala Phe Leu Leu Ser Lys Pro Thr His Glu Met Val Glu 
        115                 120                 125             


Phe Met Met Ser Gly Ile Thr Lys Tyr Glu Leu Gly Val Glu Ser Glu 
    130                 135                 140                 


Asn Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp 
145                 150                 155                 160 


Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Phe Met Arg Tyr 
                165                 170                 175     


Ile Val Arg Arg Arg Glu Thr Leu Phe Ala Arg Phe Val Phe Arg Asn 
            180                 185                 190         


His Pro Lys Leu Val Lys Thr Pro Trp Tyr Tyr Asp Pro Ala Met Lys 
        195                 200                 205             


Met Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Glu Thr Leu 
    210                 215                 220                 


Val Val Gly Val Ser Glu Arg Thr Asp Leu Asp Thr Ile Thr Leu Leu 
225                 230                 235                 240 


Ala Lys Asn Ile Lys Ala Asn Lys Glu Val Glu Phe Lys Arg Ile Val 
                245                 250                 255     


Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr Trp 
            260                 265                 270         


Leu Thr Met Leu Asp Lys Asn Lys Phe Leu Tyr Ser Pro Ile Ala Asn 
        275                 280                 285             


Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala Glu 
    290                 295                 300                 


Pro Gln Pro Gln Leu Asn Gly Leu Pro Leu Asp Lys Leu Leu Ala Ser 
305                 310                 315                 320 


Ile Ile Asn Lys Glu Pro Val Leu Ile Pro Ile Gly Gly Ala Gly Ala 
                325                 330                 335     


Thr Glu Met Glu Ile Ala Arg Glu Thr Asn Phe Asp Gly Thr Asn Tyr 
            340                 345                 350         


Leu Ala Ile Lys Pro Gly Leu Val Ile Gly Tyr Asp Arg Asn Glu Lys 
        355                 360                 365             


Thr Asn Ala Ala Leu Lys Ala Ala Gly Ile Thr Val Leu Pro Phe His 
    370                 375                 380                 


Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser Met 
385                 390                 395                 400 


Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 


<210>  15
<211>  402
<212>  PRT
<213>  Mycoplasma alligatoris

<400>  15

Met Ser Lys Ile Asn Val Tyr Ser Glu Val Gly Arg Leu Lys Glu Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ser Pro Thr Arg 
            20                  25                  30          


Leu Glu Glu Leu Leu Phe Ser Ala Ile Leu Glu Pro Asp Thr Ala Ile 
        35                  40                  45              


Glu Glu His Lys Arg Phe Leu Asn Val Leu Glu Lys Asn Gly Ile Lys 
    50                  55                  60                  


Ala Ile Gln Leu Asp Glu Leu Val Ala Gln Thr Tyr Asp Gln Val Asp 
65                  70                  75                  80  


Gln Lys Ile Lys Asp Glu Phe Ile Asp Gln Trp Leu Gln Glu Ala Lys 
                85                  90                  95      


Pro Val Leu Asn Asp Gln Leu Lys Lys Leu Val Lys Asn Tyr Leu Leu 
            100                 105                 110         


Lys Ser Gln Lys Glu Phe Ser Thr Lys Lys Met Val Arg Ile Met Met 
        115                 120                 125             


Ala Gly Ile Asp Lys Lys Glu Ile Asn Ile Asp Leu Asp Arg Asp Leu 
    130                 135                 140                 


Val Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala 
145                 150                 155                 160 


Ser Val Gly Asn Gly Ile Ser Leu His Asn Met Lys Tyr Gln Thr Arg 
                165                 170                 175     


Lys Arg Glu Thr Ile Phe Ala Gln Phe Ile Phe Lys Tyr Asn Lys Asp 
            180                 185                 190         


Tyr Lys Thr Thr Pro His Trp Phe Asp Arg Phe Asp His Gly Ser Ile 
        195                 200                 205             


Glu Gly Gly Asp Val Phe Val Tyr Thr Lys Asp Thr Leu Val Ile Gly 
    210                 215                 220                 


Ile Ser Glu Arg Thr Thr Lys Glu Ala Val Leu Asn Ile Ala Lys Lys 
225                 230                 235                 240 


Ile Lys Ala Asn Thr Asp Ser Lys Phe Lys Lys Ile Val Ala Ile Asn 
                245                 250                 255     


Val Pro Pro Met Pro Asn Leu Met His Leu Asp Thr Trp Ile Thr Met 
            260                 265                 270         


Val Asp His Asp Lys Phe Leu Tyr Ser Pro Asn Met Met Lys Ser Leu 
        275                 280                 285             


Lys Phe Trp Leu Ile Asp Leu Ser Lys Glu Ile Lys Met Val Glu Leu 
    290                 295                 300                 


Glu Glu Ser Leu Ser Asn Met Leu Glu Ala Ile Ile Gly Lys Lys Pro 
305                 310                 315                 320 


Ile Leu Ile Pro Ile Ala Gly Lys Asn Ala Ser Gln Leu Asp Ile Asp 
                325                 330                 335     


Ile Glu Thr His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly 
            340                 345                 350         


Val Val Val Gly Tyr Ser Arg Asn Lys Leu Thr Gln Lys Ala Leu Glu 
        355                 360                 365             


Asp Ala Gly Val Lys Val Leu Ser Phe Asp Gly Asn Gln Leu Ser Leu 
    370                 375                 380                 


Gly Met Gly Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp 
385                 390                 395                 400 


Ile Lys 
        


<210>  16
<211>  401
<212>  PRT
<213>  Mycoplasma colombinum

<400>  16

Met Ser Lys Ile Asn Val Tyr Ser Glu Ile Gly Glu Leu Lys Glu Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ser Pro Ser Arg 
            20                  25                  30          


Leu Asp Glu Leu Leu Phe Ser Ala Ile Leu Glu Pro Asn Glu Ala Ile 
        35                  40                  45              


Lys Glu His Lys Gly Phe Leu Lys Ile Leu Gln Asp Lys Gly Ile Lys 
    50                  55                  60                  


Val Ile Gln Leu Ser Asp Leu Val Ala Glu Thr Tyr Thr Tyr His Ala 
65                  70                  75                  80  


Thr Gln Lys Glu Arg Glu Ala Phe Ile Glu Lys Trp Leu Asp Glu Ala 
                85                  90                  95      


Glu Pro Ala Leu Thr Lys Asp Leu Arg Ala Lys Val Lys Ser Tyr Val 
            100                 105                 110         


Leu Ser Lys Glu Gly Thr Pro Val Ala Met Val Arg Thr Met Met Ala 
        115                 120                 125             


Gly Val Ser Lys Gln Glu Leu Asn Val Glu Ser Glu Thr Glu Leu Val 
    130                 135                 140                 


Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser 
145                 150                 155                 160 


Ala Gly Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Thr Arg Lys 
                165                 170                 175     


Arg Glu Thr Ile Phe Ala Glu Phe Ile Phe Ala Thr His Pro Asp Tyr 
            180                 185                 190         


Lys Thr Thr Pro His Trp Phe Asp Arg Leu Asp Glu Gly Asn Ile Glu 
        195                 200                 205             


Gly Gly Asp Val Phe Ile Tyr Asn Lys Asp Thr Leu Val Ile Gly Val 
    210                 215                 220                 


Ser Glu Arg Thr Asn Lys Glu Ala Ile Leu Thr Ile Ala Lys Lys Ile 
225                 230                 235                 240 


Lys Asn Asn Lys Glu Ala Lys Phe Lys Lys Ile Val Ala Ile Asn Val 
                245                 250                 255     


Pro Pro Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Val 
            260                 265                 270         


Asp Lys Asp Lys Phe Leu Tyr Ser Pro Asn Met Leu Ser Val Leu Lys 
        275                 280                 285             


Val Trp Glu Ile Asp Leu Ser Lys Glu Ile Glu Met Val Glu Thr Asn 
    290                 295                 300                 


Lys Pro Leu Ala Asp Val Leu Glu Ser Ile Ile Gly Val Lys Pro Val 
305                 310                 315                 320 


Leu Ile Pro Ile Ala Gly Lys Gly Ala Thr Gln Leu Asp Ile Asp Ile 
                325                 330                 335     


Glu Thr His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly Val 
            340                 345                 350         


Val Val Gly Tyr Ser Arg Asn Ile Lys Thr Glu Ala Ala Leu Arg Ala 
        355                 360                 365             


Ala Gly Val Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu Gly 
    370                 375                 380                 


Met Gly Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp Val 
385                 390                 395                 400 


Lys 
    


<210>  17
<211>  401
<212>  PRT
<213>  Mycoplasma gallinarum

<400>  17

Met Ser Lys Ile Arg Val Tyr Ser Glu Ile Gly Asn Leu Lys Lys Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ser Pro Ser Arg 
            20                  25                  30          


Leu Glu Glu Leu Leu Phe Ser Ala Val Leu Glu Pro Asn Ala Ala Ile 
        35                  40                  45              


Glu Glu His Lys Arg Phe Val Lys Leu Leu Glu Asp Arg Gly Ile Gln 
    50                  55                  60                  


Ala Ile Gln Leu Ser Asp Leu Val Ala Glu Thr Tyr Val Lys Tyr Ala 
65                  70                  75                  80  


Thr Ala Glu Gln Lys Ala Ala Phe Ile Glu Lys Tyr Leu Asp Glu Ala 
                85                  90                  95      


Thr Pro Ala Leu Ser Ala Glu Asn Arg Glu Arg Ala Lys Lys Tyr Ile 
            100                 105                 110         


Leu Ser Leu Glu Met Gln Pro Val Lys Met Ile Arg Thr Met Met Ala 
        115                 120                 125             


Gly Leu Ser Lys Tyr Glu Leu Asn Val Glu Ser Asn Ile Glu Leu Ile 
    130                 135                 140                 


Ile Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser 
145                 150                 155                 160 


Ala Gly Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Val Arg Lys 
                165                 170                 175     


Arg Glu Thr Ile Phe Ala Glu Phe Ile Phe Ala Ile His Pro Glu Tyr 
            180                 185                 190         


Lys Glu Thr Pro His Trp Phe Asp Arg Leu Asp His Gly Ser Ile Glu 
        195                 200                 205             


Gly Gly Asp Val Phe Val Tyr Asn Lys Asp Thr Leu Val Ile Gly Val 
    210                 215                 220                 


Ser Glu Arg Thr Asn Lys Glu Ala Ile Ile Thr Ile Ala Lys His Ile 
225                 230                 235                 240 


Gln Asp Asn Lys Glu Ala Glu Phe Lys Lys Ile Val Ala Ile Asn Val 
                245                 250                 255     


Pro Pro Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Val 
            260                 265                 270         


Asp Lys Asn Lys Phe Ile Tyr Ser Pro Asn Met Leu Ser Val Leu Lys 
        275                 280                 285             


Ile Trp Glu Ile Asp Leu Ala Lys Pro Ile Glu Met Val Glu Ser Asn 
    290                 295                 300                 


Lys Ser Leu Thr Glu Val Leu Glu Ser Ile Ile Gly Glu Lys Pro Ile 
305                 310                 315                 320 


Leu Ile Pro Ile Ala Gly Glu Gly Ala Ser Gln Leu Asp Ile Asp Ile 
                325                 330                 335     


Glu Thr His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly Val 
            340                 345                 350         


Val Val Gly Tyr Ser Arg Asn Glu Lys Thr Glu Lys Ala Leu Lys Ala 
        355                 360                 365             


Ala Gly Ile Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu Gly 
    370                 375                 380                 


Met Gly Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp Val 
385                 390                 395                 400 


Lys 
    


<210>  18
<211>  410
<212>  PRT
<213>  Mycoplasma gatea

<400>  18

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Leu Phe Val Ser Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Thr Asp Leu Val Thr 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Asn Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Thr Glu Glu Leu Lys Ser 
            100                 105                 110         


Val Val Arg Thr Tyr Leu Lys Ser Ile Lys Ser Thr Arg Glu Leu Ile 
        115                 120                 125             


Gln Met Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Val Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asn Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Glu Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Cys Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Glu 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Glu 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Ile Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Ile Asp Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  19
<211>  401
<212>  PRT
<213>  Mycoplasma iners

<400>  19

Met Ser Lys Ile Asn Val Tyr Ser Glu Ile Gly Val Leu Lys Glu Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ala Pro Ser Arg 
            20                  25                  30          


Leu Asp Glu Leu Leu Phe Ser Ala Ile Leu Glu Pro Ser Ala Ala Ile 
        35                  40                  45              


Gln Glu His Lys Ser Phe Leu Lys Ile Leu Gln Asp Arg Gly Ile Lys 
    50                  55                  60                  


Thr Ile Gln Leu Ser Asp Leu Val Ala Glu Thr Tyr Lys His Tyr Ala 
65                  70                  75                  80  


Ser Glu Ala Glu Lys Glu Ala Phe Ile Glu Lys Tyr Leu Asp Glu Ala 
                85                  90                  95      


Thr Pro Val Leu Ser Lys Asp Met Arg Ala Lys Val Lys Asn Tyr Ile 
            100                 105                 110         


Leu Ser Met Gln Gly Glu Pro Val Lys Met Val Arg Thr Met Met Ala 
        115                 120                 125             


Gly Val Ser Lys Gln Glu Leu Asn Val Glu Ser Glu Val Glu Leu Ile 
    130                 135                 140                 


Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser 
145                 150                 155                 160 


Ala Gly Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Val Arg Lys 
                165                 170                 175     


Arg Glu Thr Ile Phe Ala Glu Phe Ile Phe Ser Ile His Pro Glu Tyr 
            180                 185                 190         


Lys Lys Thr Pro His Trp Phe Asp Arg Leu Asp Asn Gly Ser Ile Glu 
        195                 200                 205             


Gly Gly Asp Val Phe Ile Tyr Asn Lys Asp Thr Leu Val Ile Gly Val 
    210                 215                 220                 


Ser Glu Arg Thr Asn Lys Glu Ala Ile Ile Thr Ile Ala Lys His Ile 
225                 230                 235                 240 


Gln Asp Asn Lys Glu Ala Gln Phe Lys Lys Ile Val Ala Ile Asn Val 
                245                 250                 255     


Pro Pro Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Val 
            260                 265                 270         


Asp Lys Asn Lys Phe Leu Tyr Ser Pro Asn Met Leu Ser Val Leu Lys 
        275                 280                 285             


Val Trp Glu Ile Asp Leu Ser Lys Pro Ile Glu Met Val Glu Thr Asn 
    290                 295                 300                 


Lys Pro Leu Ala Glu Val Leu Glu Ser Ile Ile Gly Glu Lys Pro Ile 
305                 310                 315                 320 


Leu Ile Pro Ile Ala Gly Lys Asp Ala Thr Gln Leu Asp Ile Asp Ile 
                325                 330                 335     


Glu Thr His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly Val 
            340                 345                 350         


Val Val Gly Tyr Ser Arg Asn Val Lys Thr Glu Ala Ala Leu Arg Ala 
        355                 360                 365             


Ala Gly Val Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu Gly 
    370                 375                 380                 


Met Gly Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp Val 
385                 390                 395                 400 


Lys 
    


<210>  20
<211>  410
<212>  PRT
<213>  Mycoplasma phocicerabrale

<400>  20

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Ser Phe Val Lys Gln 
    50                  55                  60                  


Leu Lys Asp Asn Gly Ile Asn Val Val Glu Leu Thr Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Phe Asp Leu Ala Ser Lys Glu Glu Gln Glu Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Ala His Lys Thr 
            100                 105                 110         


Ala Val Arg Lys Phe Leu Thr Ser Arg Lys Ser Thr Arg Glu Met Val 
        115                 120                 125             


Glu Phe Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Val Lys Thr Pro Trp Tyr Tyr Asp Pro Ala Met 
        195                 200                 205             


Lys Met Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Glu Thr Ile Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Val Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Lys Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Asn Asn 
                325                 330                 335     


Ala Ser His Ile Asp Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Lys Pro Gly Val Val Ile Gly Tyr Ala Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Ala Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  21
<211>  410
<212>  PRT
<213>  Mycoplasma phocidae

<400>  21

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Gln Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Glu Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Glu Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Lys Asn Asn Ile Asn Val Val Glu Leu Thr Asp Leu Val Ser 
65                  70                  75                  80  


Glu Thr Tyr Asp Met Val Ser Lys Glu Lys Gln Glu Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His Lys Gly 
            100                 105                 110         


Leu Val Arg Lys Phe Leu Lys Ser Leu Lys Ser Ser Lys Glu Leu Ile 
        115                 120                 125             


Gln Tyr Met Met Ala Gly Ile Thr Lys His Asp Leu Asn Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Ile Phe Ala 
            180                 185                 190         


Asn His Pro Lys Leu Met Asn Thr Pro Leu Tyr Tyr Asn Pro Asp Met 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Val Tyr Asn Asn Glu Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Asp Thr Ile Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Arg Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Asp 
    290                 295                 300                 


Glu Pro Gln Pro Lys Val Asn Gly Leu Pro Leu Glu Lys Leu Leu Glu 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Ile Leu Ile Pro Ile Ala Gly Thr Ser 
                325                 330                 335     


Ala Ser Asn Ile Asp Val Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Ala Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Val 
        355                 360                 365             


Lys Thr Asn Glu Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


Lys Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  22
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2DS1 recombinant chimeric ADI protein

<400>  22

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Asp Glu Leu Val Ala 
65                  70                  75                  80  


Gln Thr Tyr Asp Gln Val Asp Gln Lys Ile Lys Asp Glu Phe Ile Asp 
                85                  90                  95      


Gln Trp Leu Gln Glu Ala Lys Pro Val Leu Asn Asp Gln Leu Lys Lys 
            100                 105                 110         


Leu Val Lys Asn Tyr Leu Leu Lys Ser Gln Lys Glu Phe Ser Thr Lys 
        115                 120                 125             


Lys Met Val Arg Ile Met Met Ala Gly Ile Asp Lys Lys Glu Ile Asn 
    130                 135                 140                 


Ile Asp Leu Asp Arg Asp Leu Val Val Asp Pro Met Pro Asn Leu Tyr 
145                 150                 155                 160 


Phe Thr Arg Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His 
                165                 170                 175     


Tyr Met Arg Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe 
            180                 185                 190         


Val Phe Ser Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp 
        195                 200                 205             


Pro Ser Leu Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn 
    210                 215                 220                 


Asn Asp Thr Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr 
225                 230                 235                 240 


Val Thr Leu Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Ser Glu Phe 
                245                 250                 255     


Lys Arg Ile Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His 
            260                 265                 270         


Leu Asp Thr Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser 
        275                 280                 285             


Pro Ile Ala Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn 
    290                 295                 300                 


Gly Gly Ala Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly 
305                 310                 315                 320 


Leu Leu Gln Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala 
                325                 330                 335     


Gly Glu Gly Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp 
            340                 345                 350         


Gly Thr Asn Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser 
        355                 360                 365             


Arg Asn Glu Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val 
    370                 375                 380                 


Leu Pro Phe His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg 
385                 390                 395                 400 


Cys Met Ser Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410             


<210>  23
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2DS3 recombinant chimeric ADI protein

<400>  23

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Val Asp Leu Ile Val 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Lys Glu Ala Lys Glu Lys Leu Leu Glu 
                85                  90                  95      


Glu Phe Leu Asp Asp Ser Val Pro Val Leu Ser Asp Glu His Arg Ala 
            100                 105                 110         


Thr Val Lys Lys Phe Leu Gln Ser Gln Lys Ser Thr Arg Ser Leu Val 
        115                 120                 125             


Glu Tyr Met Ile Ala Gly Ile Thr Lys His Asp Leu Lys Ile Glu Ser 
    130                 135                 140                 


Asp Leu Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Ser Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  24
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2DS4 recombinant chimeric ADI protein

<400>  24

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Ser Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Thr Tyr His Ala Thr Gln Lys Glu Arg Glu Ala Phe Ile 
                85                  90                  95      


Glu Lys Trp Leu Asp Glu Ala Glu Pro Ala Leu Thr Lys Asp Leu Arg 
            100                 105                 110         


Ala Lys Val Lys Ser Tyr Val Leu Ser Lys Glu Gly Thr Pro Val Ala 
        115                 120                 125             


Met Val Arg Thr Met Met Ala Gly Val Ser Lys Gln Glu Leu Asn Val 
    130                 135                 140                 


Glu Ser Glu Thr Glu Leu Val Val Asp Pro Met Pro Asn Leu Tyr Phe 
145                 150                 155                 160 


Thr Arg Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr 
                165                 170                 175     


Met Arg Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val 
            180                 185                 190         


Phe Ser Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro 
        195                 200                 205             


Ser Leu Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn 
    210                 215                 220                 


Asp Thr Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val 
225                 230                 235                 240 


Thr Leu Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Ser Glu Phe Lys 
                245                 250                 255     


Arg Ile Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu 
            260                 265                 270         


Asp Thr Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro 
        275                 280                 285             


Ile Ala Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly 
    290                 295                 300                 


Gly Ala Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu 
305                 310                 315                 320 


Leu Gln Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly 
                325                 330                 335     


Glu Gly Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly 
            340                 345                 350         


Thr Asn Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg 
        355                 360                 365             


Asn Glu Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu 
    370                 375                 380                 


Pro Phe His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys 
385                 390                 395                 400 


Met Ser Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410         


<210>  25
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2DS5 recombinant chimeric ADI protein

<400>  25

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Thr Asp Leu Val Thr 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Asn Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Thr Glu Glu Leu Lys Ser 
            100                 105                 110         


Val Val Arg Thr Tyr Leu Lys Ser Ile Lys Ser Thr Arg Glu Leu Ile 
        115                 120                 125             


Gln Met Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Ser Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  26
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2DS6 recombinant chimeric ADI protein

<400>  26

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Thr Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Phe Asp Leu Ala Ser Lys Glu Glu Gln Glu Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Ala His Lys Thr 
            100                 105                 110         


Ala Val Arg Lys Phe Leu Thr Ser Arg Lys Ser Thr Arg Glu Met Val 
        115                 120                 125             


Glu Phe Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Ser Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  27
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C2DS7 recombinant chimeric ADI protein

<400>  27

Met Ser Val Phe Asp Ser Lys Phe Lys Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Gln Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Thr Asp Leu Val Ser 
65                  70                  75                  80  


Glu Thr Tyr Asp Met Val Ser Lys Glu Lys Gln Glu Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His Lys Gly 
            100                 105                 110         


Leu Val Arg Lys Phe Leu Lys Ser Leu Lys Ser Ser Lys Glu Leu Ile 
        115                 120                 125             


Gln Tyr Met Met Ala Gly Ile Thr Lys His Asp Leu Asn Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Ile Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Gln Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Ser Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Met Glu Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  28
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4DS1 recombinant chimeric ADI protein

<400>  28

Met Ser Lys Ile Asn Val Tyr Ser Glu Ile Gly Glu Leu Lys Glu Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ser Pro Ser Arg 
            20                  25                  30          


Leu Asp Glu Leu Leu Phe Ser Ala Ile Leu Glu Pro Asn Glu Ala Ile 
        35                  40                  45              


Lys Glu His Lys Gly Phe Leu Lys Ile Leu Gln Asp Lys Gly Ile Lys 
    50                  55                  60                  


Val Ile Gln Leu Asp Glu Leu Val Ala Gln Thr Tyr Asp Gln Val Asp 
65                  70                  75                  80  


Gln Lys Ile Lys Asp Glu Phe Ile Asp Gln Trp Leu Gln Glu Ala Lys 
                85                  90                  95      


Pro Val Leu Asn Asp Gln Leu Lys Lys Leu Val Lys Asn Tyr Leu Leu 
            100                 105                 110         


Lys Ser Gln Lys Glu Phe Ser Thr Lys Lys Met Val Arg Ile Met Met 
        115                 120                 125             


Ala Gly Ile Asp Lys Lys Glu Ile Asn Ile Asp Leu Asp Arg Asp Leu 
    130                 135                 140                 


Val Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala 
145                 150                 155                 160 


Ser Ala Gly Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Thr Arg 
                165                 170                 175     


Lys Arg Glu Thr Ile Phe Ala Glu Phe Ile Phe Ala Thr His Pro Asp 
            180                 185                 190         


Tyr Lys Thr Thr Pro His Trp Phe Asp Arg Leu Asp Glu Gly Asn Ile 
        195                 200                 205             


Glu Gly Gly Asp Val Phe Ile Tyr Asn Lys Asp Thr Leu Val Ile Gly 
    210                 215                 220                 


Val Ser Glu Arg Thr Asn Lys Glu Ala Ile Leu Thr Ile Ala Lys Lys 
225                 230                 235                 240 


Ile Lys Asn Asn Lys Glu Ala Lys Phe Lys Lys Ile Val Ala Ile Asn 
                245                 250                 255     


Val Pro Pro Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met 
            260                 265                 270         


Val Asp Lys Asp Lys Phe Leu Tyr Ser Pro Asn Met Leu Ser Val Leu 
        275                 280                 285             


Lys Val Trp Glu Ile Asp Leu Ser Lys Glu Ile Glu Met Val Glu Thr 
    290                 295                 300                 


Asn Lys Pro Leu Ala Asp Val Leu Glu Ser Ile Ile Gly Val Lys Pro 
305                 310                 315                 320 


Val Leu Ile Pro Ile Ala Gly Lys Gly Ala Thr Gln Leu Asp Ile Asp 
                325                 330                 335     


Ile Glu Thr His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly 
            340                 345                 350         


Val Val Val Gly Tyr Ser Arg Asn Ile Lys Thr Glu Ala Ala Leu Arg 
        355                 360                 365             


Ala Ala Gly Val Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu 
    370                 375                 380                 


Gly Met Gly Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp 
385                 390                 395                 400 


Val Lys 
        


<210>  29
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4DS2 recombinant chimeric ADI protein

<400>  29

Met Ser Lys Ile Asn Val Tyr Ser Glu Ile Gly Glu Leu Lys Glu Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ser Pro Ser Arg 
            20                  25                  30          


Leu Asp Glu Leu Leu Phe Ser Ala Ile Leu Glu Pro Asn Glu Ala Ile 
        35                  40                  45              


Lys Glu His Lys Gly Phe Leu Lys Ile Leu Gln Asp Lys Gly Ile Lys 
    50                  55                  60                  


Val Ile Gln Leu Ile Asp Leu Val Ala Glu Thr Tyr Asp Leu Ala Ser 
65                  70                  75                  80  


Gln Glu Ala Lys Asp Lys Leu Ile Glu Glu Phe Leu Glu Asp Ser Glu 
                85                  90                  95      


Pro Val Leu Ser Glu Glu His Lys Val Val Val Arg Asn Phe Leu Lys 
            100                 105                 110         


Ala Lys Lys Thr Ser Arg Glu Leu Val Glu Ile Met Met Ala Gly Ile 
        115                 120                 125             


Thr Lys Tyr Asp Leu Gly Ile Glu Ala Asp His Glu Leu Ile Val Asp 
    130                 135                 140                 


Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser Ala Gly 
145                 150                 155                 160 


Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Thr Arg Lys Arg Glu 
                165                 170                 175     


Thr Ile Phe Ala Glu Phe Ile Phe Ala Thr His Pro Asp Tyr Lys Thr 
            180                 185                 190         


Thr Pro His Trp Phe Asp Arg Leu Asp Glu Gly Asn Ile Glu Gly Gly 
        195                 200                 205             


Asp Val Phe Ile Tyr Asn Lys Asp Thr Leu Val Ile Gly Val Ser Glu 
    210                 215                 220                 


Arg Thr Asn Lys Glu Ala Ile Leu Thr Ile Ala Lys Lys Ile Lys Asn 
225                 230                 235                 240 


Asn Lys Glu Ala Lys Phe Lys Lys Ile Val Ala Ile Asn Val Pro Pro 
                245                 250                 255     


Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Val Asp Lys 
            260                 265                 270         


Asp Lys Phe Leu Tyr Ser Pro Asn Met Leu Ser Val Leu Lys Val Trp 
        275                 280                 285             


Glu Ile Asp Leu Ser Lys Glu Ile Glu Met Val Glu Thr Asn Lys Pro 
    290                 295                 300                 


Leu Ala Asp Val Leu Glu Ser Ile Ile Gly Val Lys Pro Val Leu Ile 
305                 310                 315                 320 


Pro Ile Ala Gly Lys Gly Ala Thr Gln Leu Asp Ile Asp Ile Glu Thr 
                325                 330                 335     


His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly Val Val Val 
            340                 345                 350         


Gly Tyr Ser Arg Asn Ile Lys Thr Glu Ala Ala Leu Arg Ala Ala Gly 
        355                 360                 365             


Val Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu Gly Met Gly 
    370                 375                 380                 


Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp Val Lys 
385                 390                 395                 


<210>  30
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4DS3 recombinant chimeric ADI protein

<400>  30

Met Ser Lys Ile Asn Val Tyr Ser Glu Ile Gly Glu Leu Lys Glu Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ser Pro Ser Arg 
            20                  25                  30          


Leu Asp Glu Leu Leu Phe Ser Ala Ile Leu Glu Pro Asn Glu Ala Ile 
        35                  40                  45              


Lys Glu His Lys Gly Phe Leu Lys Ile Leu Gln Asp Lys Gly Ile Lys 
    50                  55                  60                  


Val Ile Gln Leu Val Asp Leu Ile Val Glu Thr Tyr Asp Leu Ala Ser 
65                  70                  75                  80  


Lys Glu Ala Lys Glu Lys Leu Leu Glu Glu Phe Leu Asp Asp Ser Val 
                85                  90                  95      


Pro Val Leu Ser Asp Glu His Arg Ala Thr Val Lys Lys Phe Leu Gln 
            100                 105                 110         


Ser Gln Lys Ser Thr Arg Ser Leu Val Glu Tyr Met Ile Ala Gly Ile 
        115                 120                 125             


Thr Lys His Asp Leu Lys Ile Glu Ser Asp Leu Glu Leu Ile Val Asp 
    130                 135                 140                 


Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser Ala Gly 
145                 150                 155                 160 


Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Thr Arg Lys Arg Glu 
                165                 170                 175     


Thr Ile Phe Ala Glu Phe Ile Phe Ala Thr His Pro Asp Tyr Lys Thr 
            180                 185                 190         


Thr Pro His Trp Phe Asp Arg Leu Asp Glu Gly Asn Ile Glu Gly Gly 
        195                 200                 205             


Asp Val Phe Ile Tyr Asn Lys Asp Thr Leu Val Ile Gly Val Ser Glu 
    210                 215                 220                 


Arg Thr Asn Lys Glu Ala Ile Leu Thr Ile Ala Lys Lys Ile Lys Asn 
225                 230                 235                 240 


Asn Lys Glu Ala Lys Phe Lys Lys Ile Val Ala Ile Asn Val Pro Pro 
                245                 250                 255     


Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Val Asp Lys 
            260                 265                 270         


Asp Lys Phe Leu Tyr Ser Pro Asn Met Leu Ser Val Leu Lys Val Trp 
        275                 280                 285             


Glu Ile Asp Leu Ser Lys Glu Ile Glu Met Val Glu Thr Asn Lys Pro 
    290                 295                 300                 


Leu Ala Asp Val Leu Glu Ser Ile Ile Gly Val Lys Pro Val Leu Ile 
305                 310                 315                 320 


Pro Ile Ala Gly Lys Gly Ala Thr Gln Leu Asp Ile Asp Ile Glu Thr 
                325                 330                 335     


His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly Val Val Val 
            340                 345                 350         


Gly Tyr Ser Arg Asn Ile Lys Thr Glu Ala Ala Leu Arg Ala Ala Gly 
        355                 360                 365             


Val Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu Gly Met Gly 
    370                 375                 380                 


Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp Val Lys 
385                 390                 395                 


<210>  31
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4DS5 recombinant chimeric ADI protein

<400>  31

Met Ser Lys Ile Asn Val Tyr Ser Glu Ile Gly Glu Leu Lys Glu Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ser Pro Ser Arg 
            20                  25                  30          


Leu Asp Glu Leu Leu Phe Ser Ala Ile Leu Glu Pro Asn Glu Ala Ile 
        35                  40                  45              


Lys Glu His Lys Gly Phe Leu Lys Ile Leu Gln Asp Lys Gly Ile Lys 
    50                  55                  60                  


Val Ile Gln Leu Thr Asp Leu Val Thr Glu Thr Tyr Asp Leu Ala Ser 
65                  70                  75                  80  


Gln Glu Ala Lys Asp Asn Leu Ile Glu Glu Phe Leu Glu Asp Ser Glu 
                85                  90                  95      


Pro Val Leu Thr Glu Glu Leu Lys Ser Val Val Arg Thr Tyr Leu Lys 
            100                 105                 110         


Ser Ile Lys Ser Thr Arg Glu Leu Ile Gln Met Met Met Ala Gly Ile 
        115                 120                 125             


Thr Lys Tyr Asp Leu Gly Ile Glu Ala Asp His Glu Leu Ile Val Asp 
    130                 135                 140                 


Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser Ala Gly 
145                 150                 155                 160 


Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Thr Arg Lys Arg Glu 
                165                 170                 175     


Thr Ile Phe Ala Glu Phe Ile Phe Ala Thr His Pro Asp Tyr Lys Thr 
            180                 185                 190         


Thr Pro His Trp Phe Asp Arg Leu Asp Glu Gly Asn Ile Glu Gly Gly 
        195                 200                 205             


Asp Val Phe Ile Tyr Asn Lys Asp Thr Leu Val Ile Gly Val Ser Glu 
    210                 215                 220                 


Arg Thr Asn Lys Glu Ala Ile Leu Thr Ile Ala Lys Lys Ile Lys Asn 
225                 230                 235                 240 


Asn Lys Glu Ala Lys Phe Lys Lys Ile Val Ala Ile Asn Val Pro Pro 
                245                 250                 255     


Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Val Asp Lys 
            260                 265                 270         


Asp Lys Phe Leu Tyr Ser Pro Asn Met Leu Ser Val Leu Lys Val Trp 
        275                 280                 285             


Glu Ile Asp Leu Ser Lys Glu Ile Glu Met Val Glu Thr Asn Lys Pro 
    290                 295                 300                 


Leu Ala Asp Val Leu Glu Ser Ile Ile Gly Val Lys Pro Val Leu Ile 
305                 310                 315                 320 


Pro Ile Ala Gly Lys Gly Ala Thr Gln Leu Asp Ile Asp Ile Glu Thr 
                325                 330                 335     


His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly Val Val Val 
            340                 345                 350         


Gly Tyr Ser Arg Asn Ile Lys Thr Glu Ala Ala Leu Arg Ala Ala Gly 
        355                 360                 365             


Val Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu Gly Met Gly 
    370                 375                 380                 


Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp Val Lys 
385                 390                 395                 


<210>  32
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4DS6 recombinant chimeric ADI protein

<400>  32

Met Ser Lys Ile Asn Val Tyr Ser Glu Ile Gly Glu Leu Lys Glu Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ser Pro Ser Arg 
            20                  25                  30          


Leu Asp Glu Leu Leu Phe Ser Ala Ile Leu Glu Pro Asn Glu Ala Ile 
        35                  40                  45              


Lys Glu His Lys Gly Phe Leu Lys Ile Leu Gln Asp Lys Gly Ile Lys 
    50                  55                  60                  


Val Ile Gln Leu Thr Asp Leu Val Ala Glu Thr Phe Asp Leu Ala Ser 
65                  70                  75                  80  


Lys Glu Glu Gln Glu Lys Leu Ile Glu Glu Phe Leu Glu Asp Ser Glu 
                85                  90                  95      


Pro Val Leu Ser Glu Ala His Lys Thr Ala Val Arg Lys Phe Leu Thr 
            100                 105                 110         


Ser Arg Lys Ser Thr Arg Glu Met Val Glu Phe Met Met Ala Gly Ile 
        115                 120                 125             


Thr Lys Tyr Asp Leu Gly Ile Glu Ala Asp His Glu Leu Ile Val Asp 
    130                 135                 140                 


Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser Ala Gly 
145                 150                 155                 160 


Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Thr Arg Lys Arg Glu 
                165                 170                 175     


Thr Ile Phe Ala Glu Phe Ile Phe Ala Thr His Pro Asp Tyr Lys Thr 
            180                 185                 190         


Thr Pro His Trp Phe Asp Arg Leu Asp Glu Gly Asn Ile Glu Gly Gly 
        195                 200                 205             


Asp Val Phe Ile Tyr Asn Lys Asp Thr Leu Val Ile Gly Val Ser Glu 
    210                 215                 220                 


Arg Thr Asn Lys Glu Ala Ile Leu Thr Ile Ala Lys Lys Ile Lys Asn 
225                 230                 235                 240 


Asn Lys Glu Ala Lys Phe Lys Lys Ile Val Ala Ile Asn Val Pro Pro 
                245                 250                 255     


Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Val Asp Lys 
            260                 265                 270         


Asp Lys Phe Leu Tyr Ser Pro Asn Met Leu Ser Val Leu Lys Val Trp 
        275                 280                 285             


Glu Ile Asp Leu Ser Lys Glu Ile Glu Met Val Glu Thr Asn Lys Pro 
    290                 295                 300                 


Leu Ala Asp Val Leu Glu Ser Ile Ile Gly Val Lys Pro Val Leu Ile 
305                 310                 315                 320 


Pro Ile Ala Gly Lys Gly Ala Thr Gln Leu Asp Ile Asp Ile Glu Thr 
                325                 330                 335     


His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly Val Val Val 
            340                 345                 350         


Gly Tyr Ser Arg Asn Ile Lys Thr Glu Ala Ala Leu Arg Ala Ala Gly 
        355                 360                 365             


Val Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu Gly Met Gly 
    370                 375                 380                 


Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp Val Lys 
385                 390                 395                 


<210>  33
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4DS7 recombinant chimeric ADI protein

<400>  33

Met Ser Lys Ile Asn Val Tyr Ser Glu Ile Gly Glu Leu Lys Glu Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ser Pro Ser Arg 
            20                  25                  30          


Leu Asp Glu Leu Leu Phe Ser Ala Ile Leu Glu Pro Asn Glu Ala Ile 
        35                  40                  45              


Lys Glu His Lys Gly Phe Leu Lys Ile Leu Gln Asp Lys Gly Ile Lys 
    50                  55                  60                  


Val Ile Gln Leu Thr Asp Leu Val Ser Glu Thr Tyr Asp Met Val Ser 
65                  70                  75                  80  


Lys Glu Lys Gln Glu Lys Leu Ile Glu Glu Phe Leu Glu Asp Ser Glu 
                85                  90                  95      


Pro Val Leu Ser Glu Glu His Lys Gly Leu Val Arg Lys Phe Leu Lys 
            100                 105                 110         


Ser Leu Lys Ser Ser Lys Glu Leu Ile Gln Tyr Met Met Ala Gly Ile 
        115                 120                 125             


Thr Lys His Asp Leu Asn Ile Glu Ala Asp His Glu Leu Ile Val Asp 
    130                 135                 140                 


Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser Ala Gly 
145                 150                 155                 160 


Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Thr Arg Lys Arg Glu 
                165                 170                 175     


Thr Ile Phe Ala Glu Phe Ile Phe Ala Thr His Pro Asp Tyr Lys Thr 
            180                 185                 190         


Thr Pro His Trp Phe Asp Arg Leu Asp Glu Gly Asn Ile Glu Gly Gly 
        195                 200                 205             


Asp Val Phe Ile Tyr Asn Lys Asp Thr Leu Val Ile Gly Val Ser Glu 
    210                 215                 220                 


Arg Thr Asn Lys Glu Ala Ile Leu Thr Ile Ala Lys Lys Ile Lys Asn 
225                 230                 235                 240 


Asn Lys Glu Ala Lys Phe Lys Lys Ile Val Ala Ile Asn Val Pro Pro 
                245                 250                 255     


Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Val Asp Lys 
            260                 265                 270         


Asp Lys Phe Leu Tyr Ser Pro Asn Met Leu Ser Val Leu Lys Val Trp 
        275                 280                 285             


Glu Ile Asp Leu Ser Lys Glu Ile Glu Met Val Glu Thr Asn Lys Pro 
    290                 295                 300                 


Leu Ala Asp Val Leu Glu Ser Ile Ile Gly Val Lys Pro Val Leu Ile 
305                 310                 315                 320 


Pro Ile Ala Gly Lys Gly Ala Thr Gln Leu Asp Ile Asp Ile Glu Thr 
                325                 330                 335     


His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly Val Val Val 
            340                 345                 350         


Gly Tyr Ser Arg Asn Ile Lys Thr Glu Ala Ala Leu Arg Ala Ala Gly 
        355                 360                 365             


Val Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu Gly Met Gly 
    370                 375                 380                 


Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp Val Lys 
385                 390                 395                 


<210>  34
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4DS8 recombinant chimeric ADI protein

<400>  34

Met Ser Lys Ile Asn Val Tyr Ser Glu Ile Gly Glu Leu Lys Glu Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ser Pro Ser Arg 
            20                  25                  30          


Leu Asp Glu Leu Leu Phe Ser Ala Ile Leu Glu Pro Asn Glu Ala Ile 
        35                  40                  45              


Lys Glu His Lys Gly Phe Leu Lys Ile Leu Gln Asp Lys Gly Ile Lys 
    50                  55                  60                  


Val Ile Gln Leu Ser Asp Leu Val Ala Glu Thr Tyr Val Lys Tyr Ala 
65                  70                  75                  80  


Thr Ala Glu Gln Lys Ala Ala Phe Ile Glu Lys Tyr Leu Asp Glu Ala 
                85                  90                  95      


Thr Pro Ala Leu Ser Ala Glu Asn Arg Glu Arg Ala Lys Lys Tyr Ile 
            100                 105                 110         


Leu Ser Leu Glu Met Gln Pro Val Lys Met Ile Arg Thr Met Met Ala 
        115                 120                 125             


Gly Leu Ser Lys Tyr Glu Leu Asn Val Glu Ser Asn Ile Glu Leu Ile 
    130                 135                 140                 


Ile Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser 
145                 150                 155                 160 


Ala Gly Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Thr Arg Lys 
                165                 170                 175     


Arg Glu Thr Ile Phe Ala Glu Phe Ile Phe Ala Thr His Pro Asp Tyr 
            180                 185                 190         


Lys Thr Thr Pro His Trp Phe Asp Arg Leu Asp Glu Gly Asn Ile Glu 
        195                 200                 205             


Gly Gly Asp Val Phe Ile Tyr Asn Lys Asp Thr Leu Val Ile Gly Val 
    210                 215                 220                 


Ser Glu Arg Thr Asn Lys Glu Ala Ile Leu Thr Ile Ala Lys Lys Ile 
225                 230                 235                 240 


Lys Asn Asn Lys Glu Ala Lys Phe Lys Lys Ile Val Ala Ile Asn Val 
                245                 250                 255     


Pro Pro Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Val 
            260                 265                 270         


Asp Lys Asp Lys Phe Leu Tyr Ser Pro Asn Met Leu Ser Val Leu Lys 
        275                 280                 285             


Val Trp Glu Ile Asp Leu Ser Lys Glu Ile Glu Met Val Glu Thr Asn 
    290                 295                 300                 


Lys Pro Leu Ala Asp Val Leu Glu Ser Ile Ile Gly Val Lys Pro Val 
305                 310                 315                 320 


Leu Ile Pro Ile Ala Gly Lys Gly Ala Thr Gln Leu Asp Ile Asp Ile 
                325                 330                 335     


Glu Thr His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly Val 
            340                 345                 350         


Val Val Gly Tyr Ser Arg Asn Ile Lys Thr Glu Ala Ala Leu Arg Ala 
        355                 360                 365             


Ala Gly Val Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu Gly 
    370                 375                 380                 


Met Gly Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp Val 
385                 390                 395                 400 


Lys 
    


<210>  35
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C4DS9 recombinant chimeric ADI protein

<400>  35

Met Ser Lys Ile Asn Val Tyr Ser Glu Ile Gly Glu Leu Lys Glu Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ser Pro Ser Arg 
            20                  25                  30          


Leu Asp Glu Leu Leu Phe Ser Ala Ile Leu Glu Pro Asn Glu Ala Ile 
        35                  40                  45              


Lys Glu His Lys Gly Phe Leu Lys Ile Leu Gln Asp Lys Gly Ile Lys 
    50                  55                  60                  


Val Ile Gln Leu Ser Asp Leu Val Ala Glu Thr Tyr Lys His Tyr Ala 
65                  70                  75                  80  


Ser Glu Ala Glu Lys Glu Ala Phe Ile Glu Lys Tyr Leu Asp Glu Ala 
                85                  90                  95      


Thr Pro Val Leu Ser Lys Asp Met Arg Ala Lys Val Lys Asn Tyr Ile 
            100                 105                 110         


Leu Ser Met Gln Gly Glu Pro Val Lys Met Val Arg Thr Met Met Ala 
        115                 120                 125             


Gly Val Ser Lys Gln Glu Leu Asn Val Glu Ser Glu Val Glu Leu Ile 
    130                 135                 140                 


Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser 
145                 150                 155                 160 


Ala Gly Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Thr Arg Lys 
                165                 170                 175     


Arg Glu Thr Ile Phe Ala Glu Phe Ile Phe Ala Thr His Pro Asp Tyr 
            180                 185                 190         


Lys Thr Thr Pro His Trp Phe Asp Arg Leu Asp Glu Gly Asn Ile Glu 
        195                 200                 205             


Gly Gly Asp Val Phe Ile Tyr Asn Lys Asp Thr Leu Val Ile Gly Val 
    210                 215                 220                 


Ser Glu Arg Thr Asn Lys Glu Ala Ile Leu Thr Ile Ala Lys Lys Ile 
225                 230                 235                 240 


Lys Asn Asn Lys Glu Ala Lys Phe Lys Lys Ile Val Ala Ile Asn Val 
                245                 250                 255     


Pro Pro Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Val 
            260                 265                 270         


Asp Lys Asp Lys Phe Leu Tyr Ser Pro Asn Met Leu Ser Val Leu Lys 
        275                 280                 285             


Val Trp Glu Ile Asp Leu Ser Lys Glu Ile Glu Met Val Glu Thr Asn 
    290                 295                 300                 


Lys Pro Leu Ala Asp Val Leu Glu Ser Ile Ile Gly Val Lys Pro Val 
305                 310                 315                 320 


Leu Ile Pro Ile Ala Gly Lys Gly Ala Thr Gln Leu Asp Ile Asp Ile 
                325                 330                 335     


Glu Thr His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly Val 
            340                 345                 350         


Val Val Gly Tyr Ser Arg Asn Ile Lys Thr Glu Ala Ala Leu Arg Ala 
        355                 360                 365             


Ala Gly Val Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu Gly 
    370                 375                 380                 


Met Gly Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp Val 
385                 390                 395                 400 


Lys 
    


<210>  36
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5DS1 recombinant chimeric ADI protein

<400>  36

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Leu Phe Val Ser Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Asp Glu Leu Val Ala 
65                  70                  75                  80  


Gln Thr Tyr Asp Gln Val Asp Gln Lys Ile Lys Asp Glu Phe Ile Asp 
                85                  90                  95      


Gln Trp Leu Gln Glu Ala Lys Pro Val Leu Asn Asp Gln Leu Lys Lys 
            100                 105                 110         


Leu Val Lys Asn Tyr Leu Leu Lys Ser Gln Lys Glu Phe Ser Thr Lys 
        115                 120                 125             


Lys Met Val Arg Ile Met Met Ala Gly Ile Asp Lys Lys Glu Ile Asn 
    130                 135                 140                 


Ile Asp Leu Asp Arg Asp Leu Val Val Asp Pro Met Pro Asn Leu Tyr 
145                 150                 155                 160 


Phe Thr Arg Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His 
                165                 170                 175     


Tyr Met Arg Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe 
            180                 185                 190         


Val Phe Ser Asn His Pro Lys Leu Val Asn Thr Pro Trp Tyr Tyr Asp 
        195                 200                 205             


Pro Ser Leu Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn 
    210                 215                 220                 


Asn Asn Thr Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Glu Thr 
225                 230                 235                 240 


Val Thr Leu Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Cys Glu Phe 
                245                 250                 255     


Lys Arg Ile Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His 
            260                 265                 270         


Leu Asp Thr Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser 
        275                 280                 285             


Pro Ile Ala Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn 
    290                 295                 300                 


Gly Gly Glu Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly 
305                 310                 315                 320 


Leu Leu Glu Ser Ile Ile Asn Lys Lys Pro Ile Leu Ile Pro Ile Ala 
                325                 330                 335     


Gly Glu Gly Ala Ser Gln Ile Asp Ile Glu Arg Glu Thr His Phe Asp 
            340                 345                 350         


Gly Thr Asn Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser 
        355                 360                 365             


Arg Asn Glu Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val 
    370                 375                 380                 


Leu Pro Phe His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg 
385                 390                 395                 400 


Cys Met Ser Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410             


<210>  37
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5DS2 recombinant chimeric ADI protein

<400>  37

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Leu Phe Val Ser Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Ile Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His Lys Val 
            100                 105                 110         


Val Val Arg Asn Phe Leu Lys Ala Lys Lys Thr Ser Arg Glu Leu Val 
        115                 120                 125             


Glu Ile Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Val Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asn Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Glu Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Cys Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Glu 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Glu 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Ile Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Ile Asp Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  38
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5DS3 recombinant chimeric ADI protein

<400>  38

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Leu Phe Val Ser Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Val Asp Leu Ile Val 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Lys Glu Ala Lys Glu Lys Leu Leu Glu 
                85                  90                  95      


Glu Phe Leu Asp Asp Ser Val Pro Val Leu Ser Asp Glu His Arg Ala 
            100                 105                 110         


Thr Val Lys Lys Phe Leu Gln Ser Gln Lys Ser Thr Arg Ser Leu Val 
        115                 120                 125             


Glu Tyr Met Ile Ala Gly Ile Thr Lys His Asp Leu Lys Ile Glu Ser 
    130                 135                 140                 


Asp Leu Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Val Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asn Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Glu Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Cys Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Glu 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Glu 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Ile Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Ile Asp Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  39
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5DS4 recombinant chimeric ADI protein

<400>  39

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Leu Phe Val Ser Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Ser Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Thr Tyr His Ala Thr Gln Lys Glu Arg Glu Ala Phe Ile 
                85                  90                  95      


Glu Lys Trp Leu Asp Glu Ala Glu Pro Ala Leu Thr Lys Asp Leu Arg 
            100                 105                 110         


Ala Lys Val Lys Ser Tyr Val Leu Ser Lys Glu Gly Thr Pro Val Ala 
        115                 120                 125             


Met Val Arg Thr Met Met Ala Gly Val Ser Lys Gln Glu Leu Asn Val 
    130                 135                 140                 


Glu Ser Glu Thr Glu Leu Val Val Asp Pro Met Pro Asn Leu Tyr Phe 
145                 150                 155                 160 


Thr Arg Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr 
                165                 170                 175     


Met Arg Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val 
            180                 185                 190         


Phe Ser Asn His Pro Lys Leu Val Asn Thr Pro Trp Tyr Tyr Asp Pro 
        195                 200                 205             


Ser Leu Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn 
    210                 215                 220                 


Asn Thr Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Glu Thr Val 
225                 230                 235                 240 


Thr Leu Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Cys Glu Phe Lys 
                245                 250                 255     


Arg Ile Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu 
            260                 265                 270         


Asp Thr Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro 
        275                 280                 285             


Ile Ala Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly 
    290                 295                 300                 


Gly Glu Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu 
305                 310                 315                 320 


Leu Glu Ser Ile Ile Asn Lys Lys Pro Ile Leu Ile Pro Ile Ala Gly 
                325                 330                 335     


Glu Gly Ala Ser Gln Ile Asp Ile Glu Arg Glu Thr His Phe Asp Gly 
            340                 345                 350         


Thr Asn Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg 
        355                 360                 365             


Asn Glu Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu 
    370                 375                 380                 


Pro Phe His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys 
385                 390                 395                 400 


Met Ser Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410         


<210>  40
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5DS6 recombinant chimeric ADI protein

<400>  40

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Leu Phe Val Ser Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Thr Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Phe Asp Leu Ala Ser Lys Glu Glu Gln Glu Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Ala His Lys Thr 
            100                 105                 110         


Ala Val Arg Lys Phe Leu Thr Ser Arg Lys Ser Thr Arg Glu Met Val 
        115                 120                 125             


Glu Phe Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Val Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asn Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Glu Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Cys Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Glu 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Glu 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Ile Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Ile Asp Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  41
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C5DS7 recombinant chimeric ADI protein

<400>  41

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Ser Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Lys Leu Phe Val Ser Glu 
    50                  55                  60                  


Leu Lys Ala Asn Asp Ile Asn Val Val Glu Leu Thr Asp Leu Val Ser 
65                  70                  75                  80  


Glu Thr Tyr Asp Met Val Ser Lys Glu Lys Gln Glu Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His Lys Gly 
            100                 105                 110         


Leu Val Arg Lys Phe Leu Lys Ser Leu Lys Ser Ser Lys Glu Leu Ile 
        115                 120                 125             


Gln Tyr Met Met Ala Gly Ile Thr Lys His Asp Leu Asn Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Val Asn Thr Pro Trp Tyr Tyr Asp Pro Ser Leu 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asn Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Glu Thr Val Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Val Ala Asn Lys Glu Cys Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Glu 
    290                 295                 300                 


Glu Pro Gln Pro Val Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Glu 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Ile Leu Ile Pro Ile Ala Gly Glu Gly 
                325                 330                 335     


Ala Ser Gln Ile Asp Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Arg Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  42
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6DS1 recombinant chimeric ADI protein

<400>  42

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Ser Phe Val Lys Gln 
    50                  55                  60                  


Leu Lys Asp Asn Gly Ile Asn Val Val Glu Leu Asp Glu Leu Val Ala 
65                  70                  75                  80  


Gln Thr Tyr Asp Gln Val Asp Gln Lys Ile Lys Asp Glu Phe Ile Asp 
                85                  90                  95      


Gln Trp Leu Gln Glu Ala Lys Pro Val Leu Asn Asp Gln Leu Lys Lys 
            100                 105                 110         


Leu Val Lys Asn Tyr Leu Leu Lys Ser Gln Lys Glu Phe Ser Thr Lys 
        115                 120                 125             


Lys Met Val Arg Ile Met Met Ala Gly Ile Asp Lys Lys Glu Ile Asn 
    130                 135                 140                 


Ile Asp Leu Asp Arg Asp Leu Val Val Asp Pro Met Pro Asn Leu Tyr 
145                 150                 155                 160 


Phe Thr Arg Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His 
                165                 170                 175     


Tyr Met Arg Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe 
            180                 185                 190         


Val Phe Ser Asn His Pro Lys Leu Val Lys Thr Pro Trp Tyr Tyr Asp 
        195                 200                 205             


Pro Ala Met Lys Met Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn 
    210                 215                 220                 


Asn Asp Thr Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Glu Thr 
225                 230                 235                 240 


Ile Thr Leu Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Val Glu Phe 
                245                 250                 255     


Lys Arg Ile Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His 
            260                 265                 270         


Leu Asp Thr Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser 
        275                 280                 285             


Pro Ile Ala Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn 
    290                 295                 300                 


Gly Gly Ala Glu Pro Gln Pro Lys Glu Asn Gly Leu Pro Leu Glu Gly 
305                 310                 315                 320 


Leu Leu Gln Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala 
                325                 330                 335     


Gly Asn Asn Ala Ser His Ile Asp Ile Glu Arg Glu Thr His Phe Asp 
            340                 345                 350         


Gly Thr Asn Tyr Leu Ala Ile Lys Pro Gly Val Val Ile Gly Tyr Ala 
        355                 360                 365             


Arg Asn Glu Lys Thr Asn Ala Ala Leu Ala Ala Ala Gly Ile Lys Val 
    370                 375                 380                 


Leu Pro Phe His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg 
385                 390                 395                 400 


Cys Met Ser Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410             


<210>  43
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6DS2 recombinant chimeric ADI protein

<400>  43

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Ser Phe Val Lys Gln 
    50                  55                  60                  


Leu Lys Asp Asn Gly Ile Asn Val Val Glu Leu Ile Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His Lys Val 
            100                 105                 110         


Val Val Arg Asn Phe Leu Lys Ala Lys Lys Thr Ser Arg Glu Leu Val 
        115                 120                 125             


Glu Ile Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Val Lys Thr Pro Trp Tyr Tyr Asp Pro Ala Met 
        195                 200                 205             


Lys Met Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Glu Thr Ile Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Val Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Lys Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Asn Asn 
                325                 330                 335     


Ala Ser His Ile Asp Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Lys Pro Gly Val Val Ile Gly Tyr Ala Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Ala Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  44
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6DS3 recombinant chimeric ADI protein

<400>  44

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Ser Phe Val Lys Gln 
    50                  55                  60                  


Leu Lys Asp Asn Gly Ile Asn Val Val Glu Leu Val Asp Leu Ile Val 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Lys Glu Ala Lys Glu Lys Leu Leu Glu 
                85                  90                  95      


Glu Phe Leu Asp Asp Ser Val Pro Val Leu Ser Asp Glu His Arg Ala 
            100                 105                 110         


Thr Val Lys Lys Phe Leu Gln Ser Gln Lys Ser Thr Arg Ser Leu Val 
        115                 120                 125             


Glu Tyr Met Ile Ala Gly Ile Thr Lys His Asp Leu Lys Ile Glu Ser 
    130                 135                 140                 


Asp Leu Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Val Lys Thr Pro Trp Tyr Tyr Asp Pro Ala Met 
        195                 200                 205             


Lys Met Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Glu Thr Ile Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Val Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Lys Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Asn Asn 
                325                 330                 335     


Ala Ser His Ile Asp Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Lys Pro Gly Val Val Ile Gly Tyr Ala Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Ala Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  45
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6DS4 recombinant chimeric ADI protein

<400>  45

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Ser Phe Val Lys Gln 
    50                  55                  60                  


Leu Lys Asp Asn Gly Ile Asn Val Val Glu Leu Ser Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Thr Tyr His Ala Thr Gln Lys Glu Arg Glu Ala Phe Ile 
                85                  90                  95      


Glu Lys Trp Leu Asp Glu Ala Glu Pro Ala Leu Thr Lys Asp Leu Arg 
            100                 105                 110         


Ala Lys Val Lys Ser Tyr Val Leu Ser Lys Glu Gly Thr Pro Val Ala 
        115                 120                 125             


Met Val Arg Thr Met Met Ala Gly Val Ser Lys Gln Glu Leu Asn Val 
    130                 135                 140                 


Glu Ser Glu Thr Glu Leu Val Val Asp Pro Met Pro Asn Leu Tyr Phe 
145                 150                 155                 160 


Thr Arg Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr 
                165                 170                 175     


Met Arg Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val 
            180                 185                 190         


Phe Ser Asn His Pro Lys Leu Val Lys Thr Pro Trp Tyr Tyr Asp Pro 
        195                 200                 205             


Ala Met Lys Met Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn 
    210                 215                 220                 


Asp Thr Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Glu Thr Ile 
225                 230                 235                 240 


Thr Leu Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Val Glu Phe Lys 
                245                 250                 255     


Arg Ile Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu 
            260                 265                 270         


Asp Thr Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro 
        275                 280                 285             


Ile Ala Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly 
    290                 295                 300                 


Gly Ala Glu Pro Gln Pro Lys Glu Asn Gly Leu Pro Leu Glu Gly Leu 
305                 310                 315                 320 


Leu Gln Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly 
                325                 330                 335     


Asn Asn Ala Ser His Ile Asp Ile Glu Arg Glu Thr His Phe Asp Gly 
            340                 345                 350         


Thr Asn Tyr Leu Ala Ile Lys Pro Gly Val Val Ile Gly Tyr Ala Arg 
        355                 360                 365             


Asn Glu Lys Thr Asn Ala Ala Leu Ala Ala Ala Gly Ile Lys Val Leu 
    370                 375                 380                 


Pro Phe His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys 
385                 390                 395                 400 


Met Ser Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410         


<210>  46
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6DS5 recombinant chimeric ADI protein

<400>  46

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Ser Phe Val Lys Gln 
    50                  55                  60                  


Leu Lys Asp Asn Gly Ile Asn Val Val Glu Leu Thr Asp Leu Val Thr 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Asn Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Thr Glu Glu Leu Lys Ser 
            100                 105                 110         


Val Val Arg Thr Tyr Leu Lys Ser Ile Lys Ser Thr Arg Glu Leu Ile 
        115                 120                 125             


Gln Met Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Val Lys Thr Pro Trp Tyr Tyr Asp Pro Ala Met 
        195                 200                 205             


Lys Met Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Glu Thr Ile Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Val Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Lys Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Asn Asn 
                325                 330                 335     


Ala Ser His Ile Asp Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Lys Pro Gly Val Val Ile Gly Tyr Ala Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Ala Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  47
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C6DS7 recombinant chimeric ADI protein

<400>  47

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Glu Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Asp Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Ser Phe Val Lys Gln 
    50                  55                  60                  


Leu Lys Asp Asn Gly Ile Asn Val Val Glu Leu Thr Asp Leu Val Ser 
65                  70                  75                  80  


Glu Thr Tyr Asp Met Val Ser Lys Glu Lys Gln Glu Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His Lys Gly 
            100                 105                 110         


Leu Val Arg Lys Phe Leu Lys Ser Leu Lys Ser Ser Lys Glu Leu Ile 
        115                 120                 125             


Gln Tyr Met Met Ala Gly Ile Thr Lys His Asp Leu Asn Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Val Phe Ser 
            180                 185                 190         


Asn His Pro Lys Leu Val Lys Thr Pro Trp Tyr Tyr Asp Pro Ala Met 
        195                 200                 205             


Lys Met Ser Ile Glu Gly Gly Asp Val Phe Ile Tyr Asn Asn Asp Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Glu Thr Ile Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Val Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Ala 
    290                 295                 300                 


Glu Pro Gln Pro Lys Glu Asn Gly Leu Pro Leu Glu Gly Leu Leu Gln 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Val Leu Ile Pro Ile Ala Gly Asn Asn 
                325                 330                 335     


Ala Ser His Ile Asp Ile Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Lys Pro Gly Val Val Ile Gly Tyr Ala Arg Asn Glu 
        355                 360                 365             


Lys Thr Asn Ala Ala Leu Ala Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


His Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  48
<211>  413
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7DS1 recombinant chimeric ADI protein

<400>  48

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Gln Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Glu Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Glu Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Lys Asn Asn Ile Asn Val Val Glu Leu Asp Glu Leu Val Ala 
65                  70                  75                  80  


Gln Thr Tyr Asp Gln Val Asp Gln Lys Ile Lys Asp Glu Phe Ile Asp 
                85                  90                  95      


Gln Trp Leu Gln Glu Ala Lys Pro Val Leu Asn Asp Gln Leu Lys Lys 
            100                 105                 110         


Leu Val Lys Asn Tyr Leu Leu Lys Ser Gln Lys Glu Phe Ser Thr Lys 
        115                 120                 125             


Lys Met Val Arg Ile Met Met Ala Gly Ile Asp Lys Lys Glu Ile Asn 
    130                 135                 140                 


Ile Asp Leu Asp Arg Asp Leu Val Val Asp Pro Met Pro Asn Leu Tyr 
145                 150                 155                 160 


Phe Thr Arg Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His 
                165                 170                 175     


Tyr Met Arg Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe 
            180                 185                 190         


Ile Phe Ala Asn His Pro Lys Leu Met Asn Thr Pro Leu Tyr Tyr Asn 
        195                 200                 205             


Pro Asp Met Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Val Tyr Asn 
    210                 215                 220                 


Asn Glu Thr Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Asp Thr 
225                 230                 235                 240 


Ile Thr Leu Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Arg Glu Phe 
                245                 250                 255     


Lys Arg Ile Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His 
            260                 265                 270         


Leu Asp Thr Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser 
        275                 280                 285             


Pro Ile Ala Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn 
    290                 295                 300                 


Gly Gly Asp Glu Pro Gln Pro Lys Val Asn Gly Leu Pro Leu Glu Lys 
305                 310                 315                 320 


Leu Leu Glu Ser Ile Ile Asn Lys Lys Pro Ile Leu Ile Pro Ile Ala 
                325                 330                 335     


Gly Thr Ser Ala Ser Asn Ile Asp Val Glu Arg Glu Thr His Phe Asp 
            340                 345                 350         


Gly Thr Asn Tyr Leu Ala Ile Ala Pro Gly Val Val Ile Gly Tyr Ser 
        355                 360                 365             


Arg Asn Val Lys Thr Asn Glu Ala Leu Glu Ala Ala Gly Ile Lys Val 
    370                 375                 380                 


Leu Pro Phe Lys Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg 
385                 390                 395                 400 


Cys Met Ser Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410             


<210>  49
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7DS2 recombinant chimeric ADI protein

<400>  49

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Gln Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Glu Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Glu Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Lys Asn Asn Ile Asn Val Val Glu Leu Ile Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Glu His Lys Val 
            100                 105                 110         


Val Val Arg Asn Phe Leu Lys Ala Lys Lys Thr Ser Arg Glu Leu Val 
        115                 120                 125             


Glu Ile Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Ile Phe Ala 
            180                 185                 190         


Asn His Pro Lys Leu Met Asn Thr Pro Leu Tyr Tyr Asn Pro Asp Met 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Val Tyr Asn Asn Glu Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Asp Thr Ile Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Arg Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Asp 
    290                 295                 300                 


Glu Pro Gln Pro Lys Val Asn Gly Leu Pro Leu Glu Lys Leu Leu Glu 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Ile Leu Ile Pro Ile Ala Gly Thr Ser 
                325                 330                 335     


Ala Ser Asn Ile Asp Val Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Ala Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Val 
        355                 360                 365             


Lys Thr Asn Glu Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


Lys Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  50
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7DS3 recombinant chimeric ADI protein

<400>  50

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Gln Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Glu Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Glu Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Lys Asn Asn Ile Asn Val Val Glu Leu Val Asp Leu Ile Val 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Lys Glu Ala Lys Glu Lys Leu Leu Glu 
                85                  90                  95      


Glu Phe Leu Asp Asp Ser Val Pro Val Leu Ser Asp Glu His Arg Ala 
            100                 105                 110         


Thr Val Lys Lys Phe Leu Gln Ser Gln Lys Ser Thr Arg Ser Leu Val 
        115                 120                 125             


Glu Tyr Met Ile Ala Gly Ile Thr Lys His Asp Leu Lys Ile Glu Ser 
    130                 135                 140                 


Asp Leu Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Ile Phe Ala 
            180                 185                 190         


Asn His Pro Lys Leu Met Asn Thr Pro Leu Tyr Tyr Asn Pro Asp Met 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Val Tyr Asn Asn Glu Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Asp Thr Ile Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Arg Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Asp 
    290                 295                 300                 


Glu Pro Gln Pro Lys Val Asn Gly Leu Pro Leu Glu Lys Leu Leu Glu 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Ile Leu Ile Pro Ile Ala Gly Thr Ser 
                325                 330                 335     


Ala Ser Asn Ile Asp Val Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Ala Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Val 
        355                 360                 365             


Lys Thr Asn Glu Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


Lys Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  51
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7DS4 recombinant chimeric ADI protein

<400>  51

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Gln Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Glu Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Glu Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Lys Asn Asn Ile Asn Val Val Glu Leu Ser Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Tyr Thr Tyr His Ala Thr Gln Lys Glu Arg Glu Ala Phe Ile 
                85                  90                  95      


Glu Lys Trp Leu Asp Glu Ala Glu Pro Ala Leu Thr Lys Asp Leu Arg 
            100                 105                 110         


Ala Lys Val Lys Ser Tyr Val Leu Ser Lys Glu Gly Thr Pro Val Ala 
        115                 120                 125             


Met Val Arg Thr Met Met Ala Gly Val Ser Lys Gln Glu Leu Asn Val 
    130                 135                 140                 


Glu Ser Glu Thr Glu Leu Val Val Asp Pro Met Pro Asn Leu Tyr Phe 
145                 150                 155                 160 


Thr Arg Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr 
                165                 170                 175     


Met Arg Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Ile 
            180                 185                 190         


Phe Ala Asn His Pro Lys Leu Met Asn Thr Pro Leu Tyr Tyr Asn Pro 
        195                 200                 205             


Asp Met Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Val Tyr Asn Asn 
    210                 215                 220                 


Glu Thr Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Asp Thr Ile 
225                 230                 235                 240 


Thr Leu Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Arg Glu Phe Lys 
                245                 250                 255     


Arg Ile Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu 
            260                 265                 270         


Asp Thr Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro 
        275                 280                 285             


Ile Ala Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly 
    290                 295                 300                 


Gly Asp Glu Pro Gln Pro Lys Val Asn Gly Leu Pro Leu Glu Lys Leu 
305                 310                 315                 320 


Leu Glu Ser Ile Ile Asn Lys Lys Pro Ile Leu Ile Pro Ile Ala Gly 
                325                 330                 335     


Thr Ser Ala Ser Asn Ile Asp Val Glu Arg Glu Thr His Phe Asp Gly 
            340                 345                 350         


Thr Asn Tyr Leu Ala Ile Ala Pro Gly Val Val Ile Gly Tyr Ser Arg 
        355                 360                 365             


Asn Val Lys Thr Asn Glu Ala Leu Glu Ala Ala Gly Ile Lys Val Leu 
    370                 375                 380                 


Pro Phe Lys Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys 
385                 390                 395                 400 


Met Ser Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410         


<210>  52
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7DS5 recombinant chimeric ADI protein

<400>  52

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Gln Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Glu Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Glu Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Lys Asn Asn Ile Asn Val Val Glu Leu Thr Asp Leu Val Thr 
65                  70                  75                  80  


Glu Thr Tyr Asp Leu Ala Ser Gln Glu Ala Lys Asp Asn Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Thr Glu Glu Leu Lys Ser 
            100                 105                 110         


Val Val Arg Thr Tyr Leu Lys Ser Ile Lys Ser Thr Arg Glu Leu Ile 
        115                 120                 125             


Gln Met Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Ile Phe Ala 
            180                 185                 190         


Asn His Pro Lys Leu Met Asn Thr Pro Leu Tyr Tyr Asn Pro Asp Met 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Val Tyr Asn Asn Glu Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Asp Thr Ile Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Arg Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Asp 
    290                 295                 300                 


Glu Pro Gln Pro Lys Val Asn Gly Leu Pro Leu Glu Lys Leu Leu Glu 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Ile Leu Ile Pro Ile Ala Gly Thr Ser 
                325                 330                 335     


Ala Ser Asn Ile Asp Val Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Ala Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Val 
        355                 360                 365             


Lys Thr Asn Glu Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


Lys Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  53
<211>  410
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C7DS6 recombinant chimeric ADI protein

<400>  53

Met Ser Val Phe Asp Ser Lys Phe Asn Gly Ile His Val Tyr Ser Glu 
1               5                   10                  15      


Ile Gly Glu Leu Gln Thr Val Leu Val His Glu Pro Gly Arg Glu Ile 
            20                  25                  30          


Glu Tyr Ile Thr Pro Ala Arg Leu Asp Glu Leu Leu Phe Ser Ala Ile 
        35                  40                  45              


Leu Glu Ser His Asp Ala Arg Lys Glu His Gln Glu Phe Val Ala Glu 
    50                  55                  60                  


Leu Lys Lys Asn Asn Ile Asn Val Val Glu Leu Thr Asp Leu Val Ala 
65                  70                  75                  80  


Glu Thr Phe Asp Leu Ala Ser Lys Glu Glu Gln Glu Lys Leu Ile Glu 
                85                  90                  95      


Glu Phe Leu Glu Asp Ser Glu Pro Val Leu Ser Glu Ala His Lys Thr 
            100                 105                 110         


Ala Val Arg Lys Phe Leu Thr Ser Arg Lys Ser Thr Arg Glu Met Val 
        115                 120                 125             


Glu Phe Met Met Ala Gly Ile Thr Lys Tyr Asp Leu Gly Ile Glu Ala 
    130                 135                 140                 


Asp His Glu Leu Ile Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg 
145                 150                 155                 160 


Asp Pro Phe Ala Ser Val Gly Asn Gly Val Thr Ile His Tyr Met Arg 
                165                 170                 175     


Tyr Lys Val Arg Gln Arg Glu Thr Leu Phe Ser Arg Phe Ile Phe Ala 
            180                 185                 190         


Asn His Pro Lys Leu Met Asn Thr Pro Leu Tyr Tyr Asn Pro Asp Met 
        195                 200                 205             


Lys Leu Ser Ile Glu Gly Gly Asp Val Phe Val Tyr Asn Asn Glu Thr 
    210                 215                 220                 


Leu Val Val Gly Val Ser Glu Arg Thr Asp Leu Asp Thr Ile Thr Leu 
225                 230                 235                 240 


Leu Ala Lys Asn Ile Lys Ala Asn Lys Glu Arg Glu Phe Lys Arg Ile 
                245                 250                 255     


Val Ala Ile Asn Val Pro Lys Trp Thr Asn Leu Met His Leu Asp Thr 
            260                 265                 270         


Trp Leu Thr Met Leu Asp Lys Asp Lys Phe Leu Tyr Ser Pro Ile Ala 
        275                 280                 285             


Asn Asp Val Phe Lys Phe Trp Asp Tyr Asp Leu Val Asn Gly Gly Asp 
    290                 295                 300                 


Glu Pro Gln Pro Lys Val Asn Gly Leu Pro Leu Glu Lys Leu Leu Glu 
305                 310                 315                 320 


Ser Ile Ile Asn Lys Lys Pro Ile Leu Ile Pro Ile Ala Gly Thr Ser 
                325                 330                 335     


Ala Ser Asn Ile Asp Val Glu Arg Glu Thr His Phe Asp Gly Thr Asn 
            340                 345                 350         


Tyr Leu Ala Ile Ala Pro Gly Val Val Ile Gly Tyr Ser Arg Asn Val 
        355                 360                 365             


Lys Thr Asn Glu Ala Leu Glu Ala Ala Gly Ile Lys Val Leu Pro Phe 
    370                 375                 380                 


Lys Gly Asn Gln Leu Ser Leu Gly Met Gly Asn Ala Arg Cys Met Ser 
385                 390                 395                 400 


Met Pro Leu Ser Arg Lys Asp Val Lys Trp 
                405                 410 


<210>  54
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C8DS3 recombinant chimeric ADI protein

<400>  54

Met Ser Lys Ile Arg Val Tyr Ser Glu Ile Gly Asn Leu Lys Lys Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ser Pro Ser Arg 
            20                  25                  30          


Leu Glu Glu Leu Leu Phe Ser Ala Val Leu Glu Pro Asn Ala Ala Ile 
        35                  40                  45              


Glu Glu His Lys Arg Phe Val Lys Leu Leu Glu Asp Arg Gly Ile Gln 
    50                  55                  60                  


Ala Ile Gln Leu Val Asp Leu Ile Val Glu Thr Tyr Asp Leu Ala Ser 
65                  70                  75                  80  


Lys Glu Ala Lys Glu Lys Leu Leu Glu Glu Phe Leu Asp Asp Ser Val 
                85                  90                  95      


Pro Val Leu Ser Asp Glu His Arg Ala Thr Val Lys Lys Phe Leu Gln 
            100                 105                 110         


Ser Gln Lys Ser Thr Arg Ser Leu Val Glu Tyr Met Ile Ala Gly Ile 
        115                 120                 125             


Thr Lys His Asp Leu Lys Ile Glu Ser Asp Leu Glu Leu Ile Val Asp 
    130                 135                 140                 


Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser Ala Gly 
145                 150                 155                 160 


Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Val Arg Lys Arg Glu 
                165                 170                 175     


Thr Ile Phe Ala Glu Phe Ile Phe Ala Ile His Pro Glu Tyr Lys Glu 
            180                 185                 190         


Thr Pro His Trp Phe Asp Arg Leu Asp His Gly Ser Ile Glu Gly Gly 
        195                 200                 205             


Asp Val Phe Val Tyr Asn Lys Asp Thr Leu Val Ile Gly Val Ser Glu 
    210                 215                 220                 


Arg Thr Asn Lys Glu Ala Ile Ile Thr Ile Ala Lys His Ile Gln Asp 
225                 230                 235                 240 


Asn Lys Glu Ala Glu Phe Lys Lys Ile Val Ala Ile Asn Val Pro Pro 
                245                 250                 255     


Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Val Asp Lys 
            260                 265                 270         


Asn Lys Phe Ile Tyr Ser Pro Asn Met Leu Ser Val Leu Lys Ile Trp 
        275                 280                 285             


Glu Ile Asp Leu Ala Lys Pro Ile Glu Met Val Glu Ser Asn Lys Ser 
    290                 295                 300                 


Leu Thr Glu Val Leu Glu Ser Ile Ile Gly Glu Lys Pro Ile Leu Ile 
305                 310                 315                 320 


Pro Ile Ala Gly Glu Gly Ala Ser Gln Leu Asp Ile Asp Ile Glu Thr 
                325                 330                 335     


His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly Val Val Val 
            340                 345                 350         


Gly Tyr Ser Arg Asn Glu Lys Thr Glu Lys Ala Leu Lys Ala Ala Gly 
        355                 360                 365             


Ile Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu Gly Met Gly 
    370                 375                 380                 


Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp Val Lys 
385                 390                 395                 


<210>  55
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C8DS4 recombinant chimeric ADI protein

<400>  55

Met Ser Lys Ile Arg Val Tyr Ser Glu Ile Gly Asn Leu Lys Lys Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ser Pro Ser Arg 
            20                  25                  30          


Leu Glu Glu Leu Leu Phe Ser Ala Val Leu Glu Pro Asn Ala Ala Ile 
        35                  40                  45              


Glu Glu His Lys Arg Phe Val Lys Leu Leu Glu Asp Arg Gly Ile Gln 
    50                  55                  60                  


Ala Ile Gln Leu Ser Asp Leu Val Ala Glu Thr Tyr Thr Tyr His Ala 
65                  70                  75                  80  


Thr Gln Lys Glu Arg Glu Ala Phe Ile Glu Lys Trp Leu Asp Glu Ala 
                85                  90                  95      


Glu Pro Ala Leu Thr Lys Asp Leu Arg Ala Lys Val Lys Ser Tyr Val 
            100                 105                 110         


Leu Ser Lys Glu Gly Thr Pro Val Ala Met Val Arg Thr Met Met Ala 
        115                 120                 125             


Gly Val Ser Lys Gln Glu Leu Asn Val Glu Ser Glu Thr Glu Leu Val 
    130                 135                 140                 


Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser 
145                 150                 155                 160 


Ala Gly Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Val Arg Lys 
                165                 170                 175     


Arg Glu Thr Ile Phe Ala Glu Phe Ile Phe Ala Ile His Pro Glu Tyr 
            180                 185                 190         


Lys Glu Thr Pro His Trp Phe Asp Arg Leu Asp His Gly Ser Ile Glu 
        195                 200                 205             


Gly Gly Asp Val Phe Val Tyr Asn Lys Asp Thr Leu Val Ile Gly Val 
    210                 215                 220                 


Ser Glu Arg Thr Asn Lys Glu Ala Ile Ile Thr Ile Ala Lys His Ile 
225                 230                 235                 240 


Gln Asp Asn Lys Glu Ala Glu Phe Lys Lys Ile Val Ala Ile Asn Val 
                245                 250                 255     


Pro Pro Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Val 
            260                 265                 270         


Asp Lys Asn Lys Phe Ile Tyr Ser Pro Asn Met Leu Ser Val Leu Lys 
        275                 280                 285             


Ile Trp Glu Ile Asp Leu Ala Lys Pro Ile Glu Met Val Glu Ser Asn 
    290                 295                 300                 


Lys Ser Leu Thr Glu Val Leu Glu Ser Ile Ile Gly Glu Lys Pro Ile 
305                 310                 315                 320 


Leu Ile Pro Ile Ala Gly Glu Gly Ala Ser Gln Leu Asp Ile Asp Ile 
                325                 330                 335     


Glu Thr His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly Val 
            340                 345                 350         


Val Val Gly Tyr Ser Arg Asn Glu Lys Thr Glu Lys Ala Leu Lys Ala 
        355                 360                 365             


Ala Gly Ile Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu Gly 
    370                 375                 380                 


Met Gly Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp Val 
385                 390                 395                 400 


Lys 
    


<210>  56
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C8DS9 recombinant chimeric ADI protein

<400>  56

Met Ser Lys Ile Arg Val Tyr Ser Glu Ile Gly Asn Leu Lys Lys Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ser Pro Ser Arg 
            20                  25                  30          


Leu Glu Glu Leu Leu Phe Ser Ala Val Leu Glu Pro Asn Ala Ala Ile 
        35                  40                  45              


Glu Glu His Lys Arg Phe Val Lys Leu Leu Glu Asp Arg Gly Ile Gln 
    50                  55                  60                  


Ala Ile Gln Leu Ser Asp Leu Val Ala Glu Thr Tyr Lys His Tyr Ala 
65                  70                  75                  80  


Ser Glu Ala Glu Lys Glu Ala Phe Ile Glu Lys Tyr Leu Asp Glu Ala 
                85                  90                  95      


Thr Pro Val Leu Ser Lys Asp Met Arg Ala Lys Val Lys Asn Tyr Ile 
            100                 105                 110         


Leu Ser Met Gln Gly Glu Pro Val Lys Met Val Arg Thr Met Met Ala 
        115                 120                 125             


Gly Val Ser Lys Gln Glu Leu Asn Val Glu Ser Glu Val Glu Leu Ile 
    130                 135                 140                 


Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser 
145                 150                 155                 160 


Ala Gly Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Val Arg Lys 
                165                 170                 175     


Arg Glu Thr Ile Phe Ala Glu Phe Ile Phe Ala Ile His Pro Glu Tyr 
            180                 185                 190         


Lys Glu Thr Pro His Trp Phe Asp Arg Leu Asp His Gly Ser Ile Glu 
        195                 200                 205             


Gly Gly Asp Val Phe Val Tyr Asn Lys Asp Thr Leu Val Ile Gly Val 
    210                 215                 220                 


Ser Glu Arg Thr Asn Lys Glu Ala Ile Ile Thr Ile Ala Lys His Ile 
225                 230                 235                 240 


Gln Asp Asn Lys Glu Ala Glu Phe Lys Lys Ile Val Ala Ile Asn Val 
                245                 250                 255     


Pro Pro Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Val 
            260                 265                 270         


Asp Lys Asn Lys Phe Ile Tyr Ser Pro Asn Met Leu Ser Val Leu Lys 
        275                 280                 285             


Ile Trp Glu Ile Asp Leu Ala Lys Pro Ile Glu Met Val Glu Ser Asn 
    290                 295                 300                 


Lys Ser Leu Thr Glu Val Leu Glu Ser Ile Ile Gly Glu Lys Pro Ile 
305                 310                 315                 320 


Leu Ile Pro Ile Ala Gly Glu Gly Ala Ser Gln Leu Asp Ile Asp Ile 
                325                 330                 335     


Glu Thr His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly Val 
            340                 345                 350         


Val Val Gly Tyr Ser Arg Asn Glu Lys Thr Glu Lys Ala Leu Lys Ala 
        355                 360                 365             


Ala Gly Ile Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu Gly 
    370                 375                 380                 


Met Gly Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp Val 
385                 390                 395                 400 


Lys 
    


<210>  57
<211>  399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9DS3 recombinant chimeric ADI protein

<400>  57

Met Ser Lys Ile Asn Val Tyr Ser Glu Ile Gly Val Leu Lys Glu Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ala Pro Ser Arg 
            20                  25                  30          


Leu Asp Glu Leu Leu Phe Ser Ala Ile Leu Glu Pro Ser Ala Ala Ile 
        35                  40                  45              


Gln Glu His Lys Ser Phe Leu Lys Ile Leu Gln Asp Arg Gly Ile Lys 
    50                  55                  60                  


Thr Ile Gln Leu Val Asp Leu Ile Val Glu Thr Tyr Asp Leu Ala Ser 
65                  70                  75                  80  


Lys Glu Ala Lys Glu Lys Leu Leu Glu Glu Phe Leu Asp Asp Ser Val 
                85                  90                  95      


Pro Val Leu Ser Asp Glu His Arg Ala Thr Val Lys Lys Phe Leu Gln 
            100                 105                 110         


Ser Gln Lys Ser Thr Arg Ser Leu Val Glu Tyr Met Ile Ala Gly Ile 
        115                 120                 125             


Thr Lys His Asp Leu Lys Ile Glu Ser Asp Leu Glu Leu Ile Val Asp 
    130                 135                 140                 


Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser Ala Gly 
145                 150                 155                 160 


Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Val Arg Lys Arg Glu 
                165                 170                 175     


Thr Ile Phe Ala Glu Phe Ile Phe Ser Ile His Pro Glu Tyr Lys Lys 
            180                 185                 190         


Thr Pro His Trp Phe Asp Arg Leu Asp Asn Gly Ser Ile Glu Gly Gly 
        195                 200                 205             


Asp Val Phe Ile Tyr Asn Lys Asp Thr Leu Val Ile Gly Val Ser Glu 
    210                 215                 220                 


Arg Thr Asn Lys Glu Ala Ile Ile Thr Ile Ala Lys His Ile Gln Asp 
225                 230                 235                 240 


Asn Lys Glu Ala Gln Phe Lys Lys Ile Val Ala Ile Asn Val Pro Pro 
                245                 250                 255     


Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Val Asp Lys 
            260                 265                 270         


Asn Lys Phe Leu Tyr Ser Pro Asn Met Leu Ser Val Leu Lys Val Trp 
        275                 280                 285             


Glu Ile Asp Leu Ser Lys Pro Ile Glu Met Val Glu Thr Asn Lys Pro 
    290                 295                 300                 


Leu Ala Glu Val Leu Glu Ser Ile Ile Gly Glu Lys Pro Ile Leu Ile 
305                 310                 315                 320 


Pro Ile Ala Gly Lys Asp Ala Thr Gln Leu Asp Ile Asp Ile Glu Thr 
                325                 330                 335     


His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly Val Val Val 
            340                 345                 350         


Gly Tyr Ser Arg Asn Val Lys Thr Glu Ala Ala Leu Arg Ala Ala Gly 
        355                 360                 365             


Val Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu Gly Met Gly 
    370                 375                 380                 


Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp Val Lys 
385                 390                 395                 


<210>  58
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9DS4 recombinant chimeric ADI protein

<400>  58

Met Ser Lys Ile Asn Val Tyr Ser Glu Ile Gly Val Leu Lys Glu Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ala Pro Ser Arg 
            20                  25                  30          


Leu Asp Glu Leu Leu Phe Ser Ala Ile Leu Glu Pro Ser Ala Ala Ile 
        35                  40                  45              


Gln Glu His Lys Ser Phe Leu Lys Ile Leu Gln Asp Arg Gly Ile Lys 
    50                  55                  60                  


Thr Ile Gln Leu Ser Asp Leu Val Ala Glu Thr Tyr Thr Tyr His Ala 
65                  70                  75                  80  


Thr Gln Lys Glu Arg Glu Ala Phe Ile Glu Lys Trp Leu Asp Glu Ala 
                85                  90                  95      


Glu Pro Ala Leu Thr Lys Asp Leu Arg Ala Lys Val Lys Ser Tyr Val 
            100                 105                 110         


Leu Ser Lys Glu Gly Thr Pro Val Ala Met Val Arg Thr Met Met Ala 
        115                 120                 125             


Gly Val Ser Lys Gln Glu Leu Asn Val Glu Ser Glu Thr Glu Leu Val 
    130                 135                 140                 


Val Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser 
145                 150                 155                 160 


Ala Gly Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Val Arg Lys 
                165                 170                 175     


Arg Glu Thr Ile Phe Ala Glu Phe Ile Phe Ser Ile His Pro Glu Tyr 
            180                 185                 190         


Lys Lys Thr Pro His Trp Phe Asp Arg Leu Asp Asn Gly Ser Ile Glu 
        195                 200                 205             


Gly Gly Asp Val Phe Ile Tyr Asn Lys Asp Thr Leu Val Ile Gly Val 
    210                 215                 220                 


Ser Glu Arg Thr Asn Lys Glu Ala Ile Ile Thr Ile Ala Lys His Ile 
225                 230                 235                 240 


Gln Asp Asn Lys Glu Ala Gln Phe Lys Lys Ile Val Ala Ile Asn Val 
                245                 250                 255     


Pro Pro Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Val 
            260                 265                 270         


Asp Lys Asn Lys Phe Leu Tyr Ser Pro Asn Met Leu Ser Val Leu Lys 
        275                 280                 285             


Val Trp Glu Ile Asp Leu Ser Lys Pro Ile Glu Met Val Glu Thr Asn 
    290                 295                 300                 


Lys Pro Leu Ala Glu Val Leu Glu Ser Ile Ile Gly Glu Lys Pro Ile 
305                 310                 315                 320 


Leu Ile Pro Ile Ala Gly Lys Asp Ala Thr Gln Leu Asp Ile Asp Ile 
                325                 330                 335     


Glu Thr His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly Val 
            340                 345                 350         


Val Val Gly Tyr Ser Arg Asn Val Lys Thr Glu Ala Ala Leu Arg Ala 
        355                 360                 365             


Ala Gly Val Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu Gly 
    370                 375                 380                 


Met Gly Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp Val 
385                 390                 395                 400 


Lys 
    


<210>  59
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C9DS8 recombinant chimeric ADI protein

<400>  59

Met Ser Lys Ile Asn Val Tyr Ser Glu Ile Gly Val Leu Lys Glu Val 
1               5                   10                  15      


Leu Val His Thr Pro Gly Asp Glu Ile Arg Arg Ile Ala Pro Ser Arg 
            20                  25                  30          


Leu Asp Glu Leu Leu Phe Ser Ala Ile Leu Glu Pro Ser Ala Ala Ile 
        35                  40                  45              


Gln Glu His Lys Ser Phe Leu Lys Ile Leu Gln Asp Arg Gly Ile Lys 
    50                  55                  60                  


Thr Ile Gln Leu Ser Asp Leu Val Ala Glu Thr Tyr Val Lys Tyr Ala 
65                  70                  75                  80  


Thr Ala Glu Gln Lys Ala Ala Phe Ile Glu Lys Tyr Leu Asp Glu Ala 
                85                  90                  95      


Thr Pro Ala Leu Ser Ala Glu Asn Arg Glu Arg Ala Lys Lys Tyr Ile 
            100                 105                 110         


Leu Ser Leu Glu Met Gln Pro Val Lys Met Ile Arg Thr Met Met Ala 
        115                 120                 125             


Gly Leu Ser Lys Tyr Glu Leu Asn Val Glu Ser Asn Ile Glu Leu Ile 
    130                 135                 140                 


Ile Asp Pro Met Pro Asn Leu Tyr Phe Thr Arg Asp Pro Phe Ala Ser 
145                 150                 155                 160 


Ala Gly Asn Gly Ile Ser Leu Asn Asn Met Lys Tyr Val Val Arg Lys 
                165                 170                 175     


Arg Glu Thr Ile Phe Ala Glu Phe Ile Phe Ser Ile His Pro Glu Tyr 
            180                 185                 190         


Lys Lys Thr Pro His Trp Phe Asp Arg Leu Asp Asn Gly Ser Ile Glu 
        195                 200                 205             


Gly Gly Asp Val Phe Ile Tyr Asn Lys Asp Thr Leu Val Ile Gly Val 
    210                 215                 220                 


Ser Glu Arg Thr Asn Lys Glu Ala Ile Ile Thr Ile Ala Lys His Ile 
225                 230                 235                 240 


Gln Asp Asn Lys Glu Ala Gln Phe Lys Lys Ile Val Ala Ile Asn Val 
                245                 250                 255     


Pro Pro Met Pro Asn Leu Met His Leu Asp Thr Trp Leu Thr Met Val 
            260                 265                 270         


Asp Lys Asn Lys Phe Leu Tyr Ser Pro Asn Met Leu Ser Val Leu Lys 
        275                 280                 285             


Val Trp Glu Ile Asp Leu Ser Lys Pro Ile Glu Met Val Glu Thr Asn 
    290                 295                 300                 


Lys Pro Leu Ala Glu Val Leu Glu Ser Ile Ile Gly Glu Lys Pro Ile 
305                 310                 315                 320 


Leu Ile Pro Ile Ala Gly Lys Asp Ala Thr Gln Leu Asp Ile Asp Ile 
                325                 330                 335     


Glu Thr His Phe Asp Gly Thr Asn Tyr Leu Thr Ile Ala Pro Gly Val 
            340                 345                 350         


Val Val Gly Tyr Ser Arg Asn Val Lys Thr Glu Ala Ala Leu Arg Ala 
        355                 360                 365             


Ala Gly Val Thr Val Leu Ser Phe Glu Gly Asn Gln Leu Ser Leu Gly 
    370                 375                 380                 


Met Gly Ser Ala Arg Cys Met Ser Met Pro Leu Val Arg Glu Asp Val 
385                 390                 395                 400 


Lys 
    


