
                                SEQUENCE LISTING

<110> TapImmune Inc.
      Florkiewicz, Robert Z.

<120> NUCLEIC ACID MOLECULE VACCINE
  COMPOSITIONS AND USES THEREOF

<130> 890079.401WO

<140> PCT                 
<141> 2015-03-17  

<150> US 61/954,588       
<151> 2014-03-17  

<160> 210

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 400
<212> DNA
<213> Artificial Sequence

<220> 
<223> Exemplary Multiplex Translation Initiation (MTI)
      sequence

<400> 1
gggtggagat gtagaagatg tgacgccgcg gcccggcggg tgccagatta gcggacgcgg      60
tgcccgcggt tgcaacggga tcccgggcgc tgcagcttgg gaggcggctc tccccaggcg     120
gcgtccgcgg agacacccat ccgtgaaccc caggtcccgg gccgccggct cgccgcgcac     180
caggggccgg cggacagaag agcggccgag cggctcgagg ctgggggacc gcgggcgcgg     240
ccgcgcgctg ccgggcggga ggctgggggg ccggggccgg ggccgtgccc cggagcgggt     300
cggaggccgg ggccggggcc gggggacggc ggctccccgc gcggctccag cggctcgggg     360
atcccggccg ggccccgcag ggaccatggc agccgggagc                           400

<210> 2
<211> 513
<212> DNA
<213> Artificial Sequence

<220> 
<223> Exemplary MTI sequence

<400> 2
gccccagaaa acccgagcga gtagggggcg gcgcgcagga gggaggagaa ctgggggcgc      60
gggaggctgg tgggtgtggg gggtggagat gtagaagatg tgacgccgcg gcccggcggg     120
tgccagatta gcggacgcgg tgcccgcggt tgcaacggga tcccgggcgc tgcagcttgg     180
gaggcggctc tccccaggcg gcgtccgcgg agacacccat ccgtgaaccc caggtcccgg     240
gccgccggct cgccgcgcac caggggccgg cggacagaag agcggccgag cggctcgagg     300
ctgggggacc gcgggcgcgg ccgcgcgctg ccgggcggga ggctgggggg ccggggccgg     360
ggccgtgccc cggagcgggt cggaggccgg ggccggggcc gggggacggc ggctccccgc     420
gcggctccag cggctcgggg atcccggccg ggccccgcag ggaccatggc agccgggagc     480
atcaccacgc tgcccgcctt gcccgaggat ggc                                  513

<210> 3
<211> 192
<212> DNA
<213> Artificial Sequence

<220> 
<223> Exemplary MTI sequence

<400> 3
agcggctcga ggctggggga ccgcgggcgc ggccgcgcgc tgccgggcgg gaggctgggg      60
ggccggggcc ggggccgtgc cccggagcgg gtcggaggcc ggggccgggg ccgggggacg     120
gcggctcccc gcgcggctcc agcggctcgg ggatcccggc cgggccccgc agggaccatg     180
gcagccggga gc                                                         192

<210> 4
<211> 177
<212> DNA
<213> Artificial Sequence

<220> 
<223> Exemplary Multiplex Translation Initiation
      sequence

<400> 4
ggggaccgcg ggcgcggccg cgcgctgccg ggcgggaggc tggggggccg gggccggggc      60
cgtgccccgg agcgggtcgg aggccggggc cggggccggg ggacggcggc tccccgcgcg     120
gctccagcgg ctcggggatc ccggccgggc cccgcaggga ccatggcagc cgggagc        177

<210> 5
<211> 150
<212> DNA
<213> Artificial Sequence

<220> 
<223> Exemplary MTI sequence

<400> 5
ccgggcggga ggctgggggg ccggggccgg ggccgtgccc cggagcgggt cggaggccgg      60
ggccggggcc gggggacggc ggctccccgc gcggctccag cggctcgggg atcccggccg     120
ggccccgcag ggaccatggc agccgggagc                                      150

<210> 6
<211> 427
<212> DNA
<213> Artificial Sequence

<220> 
<223> Exemplary MTI sequence with restriction sites on
      each end

<400> 6
atcgatggtt aacgtttaaa cgggtggaga tgtagaagat gtgacgccgc ggcccggcgg      60
gtgccagatt agcggacgcg gtgcccgcgg ttgcaacggg atcccgggcg ctgcagcttg     120
ggaggcggct ctccccaggc ggcgtccgcg gagacaccca tccgtgaacc ccaggtcccg     180
ggccgccggc tcgccgcgca ccaggggccg gcggacagaa gagcggccga gcggctcgag     240
gctgggggac cgcgggcgcg gccgcgcgct gccgggcggg aggctggggg gccggggccg     300
gggccgtgcc ccggagcggg tcggaggccg gggccggggc cgggggacgg cggctccccg     360
cgcggctcca gcggctcggg gatcccggcc gggccccgca gggaccatgg cagccgggag     420
ctctaga                                                               427

<210> 7
<211> 805
<212> DNA
<213> Artificial Sequence

<220> 
<223> MTI + Small Pox MHC Class I polyantigen array +
      VSV-g epitope tag

<400> 7
gggtggagat gtagaagatg tgacgccgcg gcccggcggg tgccagatta gcggacgcgg      60
tgcccgcggt tgcaacggga tcccgggcgc tgcagcttgg gaggcggctc tccccaggcg     120
gcgtccgcgg agacacccat ccgtgaaccc caggtcccgg gccgccggct cgccgcgcac     180
caggggccgg cggacagaag agcggccgag cggctcgagg ctgggggacc gcgggcgcgg     240
ccgcgcgctg ccgggcggga ggctgggggg ccggggccgg ggccgtgccc cggagcgggt     300
cggaggccgg ggccggggcc gggggacggc ggctccccgc gcggctccag cggctcgggg     360
atcccggccg ggccccgcag ggaccatggc agccgggagc tctagagagg tgaacaccat     420
cctgatggac aacaagggcc tgggcgtgag actggccacc ggcggcggcg gcagcggcgg     480
cggcggcagc aagagcctga ccatcctgga cgacaacctg tacaaggtgt acaacggcat     540
cggcggcggc ggcagcggcg gcggcggcag cagaaccgac gacggcctgc tggacagact     600
gtacgacctg accagatacg ccggcggcgg cggcagcggc ggcggcggca gccccctgac     660
caagggcatc ctgggcgtgt tcaccctgac cgtgcccagc ggcggcggcg gcagcggcgg     720
cggcggcagc aagatcgtga acagcctgag caacctggac ttcagactgt acaccgacat     780
cgagatgaac agactgggca agtga                                           805

<210> 8
<211> 56
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI peptide from first CUG to AUG for Class II
      peptides with bFGF peptide insert

<400> 8
Leu Gly Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly
 1               5                  10                  15
Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg
            20                  25                  30
Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser
        35                  40                  45
Arg Pro Gly Pro Ala Gly Thr Met
    50                  55

<210> 9
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI peptide from first CUG to AUG for Class II
      peptides with first nuclear localization site
      removed (delta 17-22) and bFGF peptide insert

<400> 9
Leu Gly Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly
 1               5                  10                  15
Ala Pro Glu Arg Val Gly Gly Arg Gly Arg Gly Arg Gly Thr Ala Ala
            20                  25                  30
Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro Gly Pro Ala Gly
        35                  40                  45
Thr Met
    50

<210> 10
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI peptide from first CUG to AUG for Class II
      peptides with second nuclear localization site
      removed (delta 29-34) and bFGF peptide insert

<400> 10
Leu Gly Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly
 1               5                  10                  15
Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Thr Ala Ala
            20                  25                  30
Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro Gly Pro Ala Gly
        35                  40                  45
Thr Met
    50

<210> 11
<211> 44
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI peptide from first CUG to AUG for Class II
      peptides with both nuclear localization sites
      removed (delta 17-22/29-34) and bFGF peptide
      insert

<400> 11
Leu Gly Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly
 1               5                  10                  15
Ala Pro Glu Arg Val Gly Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala
            20                  25                  30
Ala Arg Gly Ser Arg Pro Gly Pro Ala Gly Thr Met
        35                  40

<210> 12
<211> 56
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI peptide from first CUG to AUG for Class II
      peptides with both nuclear localization sites
      mutated (R(18, 20, 22, 30, 32, 34)H) and bFGF
      peptide insert

<400> 12
Leu Gly Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly
 1               5                  10                  15
Gly His Gly His Gly His Ala Pro Glu Arg Val Gly Gly His Gly His
            20                  25                  30
Gly His Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser
        35                  40                  45
Arg Pro Gly Pro Ala Gly Thr Met
    50                  55

<210> 13
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VSV-G epitope tag

<400> 13
Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys
 1               5                  10

<210> 14
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> V5 epitope tag

<400> 14
Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr
 1               5                  10

<210> 15
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> AU5 epitope tag

<400> 15
Thr Asp Phe Tyr Leu Lys
 1               5

<210> 16
<211> 1225
<212> PRT
<213> Artificial Sequence

<220> 
<223> Potential Her2neu MHC peptides

<400> 16
Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu
 1               5                  10                  15
Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu
            20                  25                  30
Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln
        35                  40                  45
Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val
    50                  55                  60
Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp
65                  70                  75                  80
Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr
                85                  90                  95
Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu
            100                 105                 110
Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn
        115                 120                 125
Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His
    130                 135                 140
Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg
145                 150                 155                 160
Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly
                165                 170                 175
Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly
            180                 185                 190
Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu
        195                 200                 205
Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala
    210                 215                 220
Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala
225                 230                 235                 240
Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu
                245                 250                 255
Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn
            260                 265                 270
Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His
        275                 280                 285
Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys
    290                 295                 300
Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu
305                 310                 315                 320
Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly
                325                 330                 335
Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp
            340                 345                 350
Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln
        355                 360                 365
Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala
    370                 375                 380
Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val
385                 390                 395                 400
Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln
                405                 410                 415
Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly
            420                 425                 430
Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His
        435                 440                 445
Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu
    450                 455                 460
His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala
465                 470                 475                 480
Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr
                485                 490                 495
Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu
            500                 505                 510
Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg
        515                 520                 525
His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val
    530                 535                 540
Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr
545                 550                 555                 560
Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro
                565                 570                 575
Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala
            580                 585                 590
Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp
        595                 600                 605
Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile
    610                 615                 620
Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val
625                 630                 635                 640
Phe Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr
                645                 650                 655
Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro
            660                 665                 670
Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr
        675                 680                 685
Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val
    690                 695                 700
Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val
705                 710                 715                 720
Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu
                725                 730                 735
Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val
            740                 745                 750
Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr
        755                 760                 765
Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg
    770                 775                 780
Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala
785                 790                 795                 800
Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu
                805                 810                 815
Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr
            820                 825                 830
Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His
        835                 840                 845
Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile
    850                 855                 860
Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val
865                 870                 875                 880
Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile
                885                 890                 895
Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro
            900                 905                 910
Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys
        915                 920                 925
Trp Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser
    930                 935                 940
Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln
945                 950                 955                 960
Asn Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg
                965                 970                 975
Ser Leu Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu
            980                 985                 990
Tyr Leu Val Pro Gln Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly
        995                 1000                1005
Ala Gly Gly Met Val His His Arg His Arg Ser Ser Ser Thr Arg Ser
    1010                1015                1020
Gly Gly Gly Asp Leu Thr Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala
1025                1030                1035                1040
Pro Arg Ser Pro Leu Ala Pro Ser Glu Gly Ala Gly Ser Asp Val Phe
                1045                1050                1055
Asp Gly Asp Leu Gly Met Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro
            1060                1065                1070
Thr His Asp Pro Ser Pro Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val
        1075                1080                1085
Pro Leu Pro Ser Glu Thr Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser
    1090                1095                1100
Pro Gln Pro Glu Tyr Val Asn Gln Pro Asp Val Arg Pro Gln Pro Pro
1105                1110                1115                1120
Ser Pro Arg Glu Gly Pro Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr
                1125                1130                1135
Leu Glu Arg Pro Lys Thr Leu Ser Pro Gly Lys Asn Gly Val Val Lys
            1140                1145                1150
Asp Val Phe Ala Phe Gly Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr
        1155                1160                1165
Pro Gln Gly Gly Ala Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser
    1170                1175                1180
Pro Ala Phe Asp Asn Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg
1185                1190                1195                1200
Gly Ala Pro Pro Ser Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro
                1205                1210                1215
Glu Tyr Leu Gly Leu Asp Val Pro Val
            1220                1225

<210> 17
<211> 180
<212> PRT
<213> Artificial Sequence

<220> 
<223> Potential NY-ESO1 MHC peptide

<400> 17
Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp
 1               5                  10                  15
Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly
            20                  25                  30
Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala
        35                  40                  45
Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro
    50                  55                  60
His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala
65                  70                  75                  80
Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe
                85                  90                  95
Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp
            100                 105                 110
Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val
        115                 120                 125
Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln
    130                 135                 140
Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met
145                 150                 155                 160
Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser
                165                 170                 175
Gly Gln Arg Arg
            180

<210> 18
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI peptide for Class II recognized by specific
      antibody

<400> 18
Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser Arg Pro Gly
 1               5                  10                  15
Pro Ala Gly


<210> 19
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Potential Her2neu MHC peptide

<400> 19
Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe
 1               5                  10                  15

<210> 20
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Potential Her2neu MHC peptide

<400> 20
His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val
 1               5                  10                  15

<210> 21
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Potential Her2neu MHC peptide

<400> 21
Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu
 1               5                  10                  15

<210> 22
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Potential Her2neu MHC peptide

<400> 22
Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly Ile
 1               5                  10                  15
Leu Ile


<210> 23
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Potential Her2neu MHC peptide

<400> 23
Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe
 1               5                  10                  15

<210> 24
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Positive Peptides From HLA-A2 Mice Virion coat
      protein

<400> 24
Val Leu Ser Leu Glu Leu Pro Glu Val
 1               5

<210> 25
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Positive Peptides From HLA-A2 Mice Hypothetical
      Protein

<400> 25
Lys Ile Asp Tyr Tyr Ile Pro Tyr Val
 1               5

<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Positive Peptides From HLA-A2 Mice Unknown
      Function

<400> 26
Ser Leu Ser Asn Leu Asp Phe Arg Leu
 1               5

<210> 27
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Positive Peptides From HLA-A2 Mice Apoptosis
      Inhibitor

<400> 27
Ile Leu Met Asp Asn Lys Gly Leu Gly Val
 1               5                  10

<210> 28
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Positive Peptides From HLA-A2 Mice Viral
      Morphogenesis

<400> 28
Ile Leu Asp Asp Asn Leu Tyr Lys Val
 1               5

<210> 29
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Positive Peptides From HLA-A2 Mice Poly(A)
      Polymerase

<400> 29
Lys Leu Leu Leu Gly Glu Leu Phe Phe Leu
 1               5                  10

<210> 30
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Positive Peptides From HLA-A2 Mice Unknown
      Function

<400> 30
Gly Leu Leu Asp Arg Leu Tyr Asp Leu
 1               5

<210> 31
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> HBV Core antigen

<400> 31
Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu
 1               5                  10

<210> 32
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 32
Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe
 1               5                  10                  15

<210> 33
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 33
His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val
 1               5                  10                  15

<210> 34
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 34
Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu
 1               5                  10                  15

<210> 35
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Peptide epitope

<400> 35
Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe
 1               5                  10                  15

<210> 36
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary Peptide epitope

<400> 36
Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp
 1               5                  10

<210> 37
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HLA Class II folate receptor alpha antigenic
      T-cell peptide

<400> 37
Arg Thr Glu Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu
 1               5                  10                  15
Lys


<210> 38
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> HLA Class II folate receptor alpha antigenic
      T-cell peptide

<400> 38
Gln Cys Arg Pro Trp Arg Lys Asn Ala Cys Cys Ser Thr Asn Thr
 1               5                  10                  15

<210> 39
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> HLA Class II folate receptor alpha antigenic
      T-cell peptide

<400> 39
Lys Asp Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu
 1               5                  10                  15
Met Ala


<210> 40
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HLA Class II folate receptor alpha antigenic
      T-cell peptide

<400> 40
Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg
 1               5                  10                  15
Val


<210> 41
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> HLA Class II folate receptor alpha antigenic
      T-cell peptide

<400> 41
Pro Trp Ala Ala Trp Pro Pro Leu Leu Ser Leu Ala Leu Met Leu Leu
 1               5                  10                  15
Trp Leu


<210> 42
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> VSVG signal sequence

<400> 42
Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys Lys
 1               5                  10                  15

<210> 43
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> VSVG signal sequence

<400> 43
aagtgcctgc tgtacctggc cttcctgttc atcggcgtga actgcaag                   48

<210> 44
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Dendritic Cell Targeting Sequence

<400> 44
Phe Tyr Pro Ser Tyr His Ser Thr Pro Gln Arg Pro
 1               5                  10

<210> 45
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Dendritic Cell Targeting Sequence

<400> 45
ttctacccca gctaccacag caccccccag agaccc                                36

<210> 46
<211> 174
<212> PRT
<213> Artificial Sequence

<220> 
<223> VSVG secretion signal

<400> 46
Phe Thr Ile Leu Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn Val
 1               5                  10                  15
Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp His
            20                  25                  30
Asn Asp Leu Ile Gly Thr Ala Ile Gln Val Lys Met Pro Lys Ser His
        35                  40                  45
Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val
    50                  55                  60
Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr Gln Ser
65                  70                  75                  80
Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu
                85                  90                  95
Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser
            100                 105                 110
Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val
        115                 120                 125
Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp
    130                 135                 140
Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val
145                 150                 155                 160
His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly
                165                 170

<210> 47
<211> 522
<212> DNA
<213> Artificial Sequence

<220> 
<223> VSVG secretion signal

<400> 47
ttcaccatac tttttccaca caaccaaaaa ggaaactgga aaaatgttcc ttctaattac      60
cattattgcc cgtcaagctc agatttaaat tggcataatg acttaatagg cacagccata     120
caagtcaaaa tgcccaagag tcacaaggct attcaagcag acggttggat gtgtcatgct     180
tccaaatggg tcactacttg tgatttccgc tggtatggac cgaagtatat aacacagtcc     240
atccgatcct tcactccatc tgtagaacaa tgcaaggaaa gcattgaaca aacgaaacaa     300
ggaacttggc tgaatccagg cttccctcct caaagttgtg gatatgcaac tgtgacggat     360
gccgaagcag tgattgtcca ggtgactcct caccatgtgc tggttgatga atacacagga     420
gaatgggttg attcacagtt catcaacgga aaatgcagca attacatatg ccccactgtc     480
cataactcta caacctggca ttctgactat aaggtcaaag gg                        522

<210> 48
<211> 456
<212> DNA
<213> Artificial Sequence

<220> 
<223> VSVG alternate trafficking signal

<400> 48
cttccaatct ctccagtgga tctcagctat cttgctccta aaaacccagg aaccggtcct      60
gctttcacca taatcaatgg taccctaaaa tactttgaga ccagatacat cagagtcgat     120
attgctgctc caatcctctc aagaatggtc ggaatgatca gtggaactac cacagaaagg     180
gaactgtggg atgactgggc accatatgaa gacgtggaaa ttggacccaa tggagttctg     240
aggaccagtt caggatataa gtttccttta tacatgattg gacatggtat gttggactcc     300
gatcttcatc ttagctcaaa ggctcaggtg ttcgaacatc ctcacattca agacgctgct     360
tcgcaacttc ctgatgatga gagtttattt tttggtgata ctgggctatc caaaaatcca     420
atcgagcttg tagaaggttg gttcagtagt tggaaa                               456

<210> 49
<211> 145
<212> PRT
<213> Artificial Sequence

<220> 
<223> Folate receptor alpha PAA - Class II with embedded
      Class I two amino acid extensions

<400> 49
Trp Ala Arg Thr Glu Leu Leu Asn Val Cys Met Asn Ala Lys His His
 1               5                  10                  15
Lys Glu Lys Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His
            20                  25                  30
Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala Cys Cys Ser Thr Asn Thr
        35                  40                  45
Ser Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala His Lys Asp
    50                  55                  60
Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala
65                  70                  75                  80
Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Asn Leu Gly
                85                  90                  95
Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg Val Leu
            100                 105                 110
Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gly Pro Trp Ala
        115                 120                 125
Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu
    130                 135                 140
Ser
145

<210> 50
<211> 447
<212> DNA
<213> Artificial Sequence

<220> 
<223> Folate receptor alpha PAA with XbaI sites

<400> 50
tctagatggg ccagaaccga gctgctgaac gtgtgcatga acgccaagca ccacaaggag      60
aagcccggcg gcggcggcgg cagcggcggc ggcggcagcc acgagcagtg cagaccctgg     120
agaaagaacg cctgctgcag caccaacacc agccagggcg gcggcggcag cggcggcggc     180
ggcagcgccc acaaggacgt gagctacctg tacagattca actggaacca ctgcggcgag     240
atggcccccg ccggcggcgg cggcagcggc ggcggcggca gccccaacct gggcccctgg     300
atccagcagg tggaccagag ctggagaaag gagagagtgc tgaacggcgg cggcggcagc     360
ggcggcggcg gcagcgccgg cccctgggcc gcctggccct tcctgctgag cctggccctg     420
atgctgctgt ggctgctgag ctctaga                                         447

<210> 51
<211> 435
<212> DNA
<213> Artificial Sequence

<220> 
<223> Folate receptor alpha PAA with two amino acid
      extensions

<400> 51
tgggccagaa ccgagctgct gaacgtgtgc atgaacgcca agcaccacaa ggagaagccc      60
ggcggcggcg gcggcagcgg cggcggcggc agccacgagc agtgcagacc ctggagaaag     120
aacgcctgct gcagcaccaa caccagccag ggcggcggcg gcagcggcgg cggcggcagc     180
gcccacaagg acgtgagcta cctgtacaga ttcaactgga accactgcgg cgagatggcc     240
cccgccggcg gcggcggcag cggcggcggc ggcagcccca acctgggccc ctggatccag     300
caggtggacc agagctggag aaaggagaga gtgctgaacg gcggcggcgg cagcggcggc     360
ggcggcagcg ccggcccctg ggccgcctgg cccttcctgc tgagcctggc cctgatgctg     420
ctgtggctgc tgagc                                                      435

<210> 52
<211> 1474
<212> DNA
<213> Artificial Sequence

<220> 
<223> MTI-PAA Folate Receptor Alpha Class II with VSVG
      secretion trafficking

<400> 52
gggtggagat gtagaagatg tgacgccgcg gcccggcggg tgccagatta gcggacgcgg      60
tgcccgcggt tgcaacggga tcccgggcgc tgcagcttgg gaggcggctc tccccaggcg     120
gcgtccgcgg agacacccat ccgtgaaccc caggtcccgg gccgccggct cgccgcgcac     180
caggggccgg cggacagaag agcggccgag cggctcgagg ctgggggacc gcgggcgcgg     240
ccgcgcgctg ccgggcggga ggctgggggg ccggggccgg ggccgtgccc cggagcgggt     300
cggaggccgg ggccggggcc gggggacggc ggctccccgc gcggctccag cggctcgggg     360
atcccggccg ggccccgcag ggaccaagtg cctgctgtac ctggccttcc tgttcatcgg     420
cgtgaactgc aagttctacc ccagctacca cagcaccccc cagagaccct tcaccatact     480
ttttccacac aaccaaaaag gaaactggaa aaatgttcct tctaattacc attattgccc     540
gtcaagctca gatttaaatt ggcataatga cttaataggc acagccatac aagtcaaaat     600
gcccaagagt cacaaggcta ttcaagcaga cggttggatg tgtcatgctt ccaaatgggt     660
cactacttgt gatttccgct ggtatggacc gaagtatata acacagtcca tccgatcctt     720
cactccatct gtagaacaat gcaaggaaag cattgaacaa acgaaacaag gaacttggct     780
gaatccaggc ttccctcctc aaagttgtgg atatgcaact gtgacggatg ccgaagcagt     840
gattgtccag gtgactcctc accatgtgct ggttgatgaa tacacaggag aatgggttga     900
ttcacagttc atcaacggaa aatgcagcaa ttacatatgc cccactgtcc ataactctac     960
aacctggcat tctgactata aggtcaaagg gtctagatgg gccagaaccg agctgctgaa    1020
cgtgtgcatg aacgccaagc accacaagga gaagcccggc ggcggcggcg gcagcggcgg    1080
cggcggcagc cacgagcagt gcagaccctg gagaaagaac gcctgctgca gcaccaacac    1140
cagccagggc ggcggcggca gcggcggcgg cggcagcgcc cacaaggacg tgagctacct    1200
gtacagattc aactggaacc actgcggcga gatggccccc gccggcggcg gcggcagcgg    1260
cggcggcggc agccccaacc tgggcccctg gatccagcag gtggaccaga gctggagaaa    1320
ggagagagtg ctgaacggcg gcggcggcag cggcggcggc ggcagcgccg gcccctgggc    1380
cgcctggccc ttcctgctga gcctggccct gatgctgctg tggctgctga gctctagata    1440
caccgacatc gagatgaaca gactgggcaa gtaa                                1474

<210> 53
<211> 417
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-PAA Folate Receptor Alpha Class II with VSVG
      secretion trafficking

<400> 53
Met Gly Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly
 1               5                  10                  15
Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg
            20                  25                  30
Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser
        35                  40                  45
Arg Pro Gly Pro Ala Gly Thr Lys Cys Leu Leu Tyr Leu Ala Phe Leu
    50                  55                  60
Phe Ile Gly Val Asn Cys Lys Phe Tyr Pro Ser Tyr His Ser Thr Pro
65                  70                  75                  80
Gln Arg Pro Phe Thr Ile Leu Phe Pro His Asn Gln Lys Gly Asn Trp
                85                  90                  95
Lys Asn Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu
            100                 105                 110
Asn Trp His Asn Asp Leu Ile Gly Thr Ala Ile Gln Val Lys Met Pro
        115                 120                 125
Lys Ser His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser
    130                 135                 140
Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile
145                 150                 155                 160
Thr Gln Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu
                165                 170                 175
Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro
            180                 185                 190
Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile
        195                 200                 205
Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu
    210                 215                 220
Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys
225                 230                 235                 240
Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys
                245                 250                 255
Gly Ser Arg Trp Ala Arg Thr Glu Leu Leu Asn Val Cys Met Asn Ala
            260                 265                 270
Lys His His Lys Glu Lys Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly
        275                 280                 285
Gly Ser His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala Cys Cys Ser
    290                 295                 300
Thr Asn Thr Ser Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala
305                 310                 315                 320
His Lys Asp Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn His Cys Gly
                325                 330                 335
Glu Met Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro
            340                 345                 350
Asn Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu
        355                 360                 365
Arg Val Leu Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Gly
    370                 375                 380
Pro Trp Ala Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu
385                 390                 395                 400
Trp Leu Leu Ser Ser Arg Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly
                405                 410                 415
Lys


<210> 54
<211> 408
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-PAA Folate Receptor Alpha Class II with VSVG
      secretion trafficking

<400> 54
Leu Pro Gly Gly Arg Leu Gly Gly Arg Gly Arg Gly Arg Ala Pro Glu
 1               5                  10                  15
Arg Val Gly Gly Arg Gly Arg Gly Arg Gly Thr Ala Ala Pro Arg Ala
            20                  25                  30
Ala Pro Ala Ala Arg Gly Ser Arg Pro Gly Pro Ala Gly Thr Lys Cys
        35                  40                  45
Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys Lys Phe Tyr
    50                  55                  60
Pro Ser Tyr His Ser Thr Pro Gln Arg Pro Phe Thr Ile Leu Phe Pro
65                  70                  75                  80
His Asn Gln Lys Gly Asn Trp Lys Asn Val Pro Ser Asn Tyr His Tyr
                85                  90                  95
Cys Pro Ser Ser Ser Asp Leu Asn Trp His Asn Asp Leu Ile Gly Thr
            100                 105                 110
Ala Ile Gln Val Lys Met Pro Lys Ser His Lys Ala Ile Gln Ala Asp
        115                 120                 125
Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg
    130                 135                 140
Trp Tyr Gly Pro Lys Tyr Ile Thr Gln Ser Ile Arg Ser Phe Thr Pro
145                 150                 155                 160
Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr
                165                 170                 175
Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val
            180                 185                 190
Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His His Val Leu
        195                 200                 205
Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly
    210                 215                 220
Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp
225                 230                 235                 240
His Ser Asp Tyr Lys Val Lys Gly Ser Arg Trp Ala Arg Thr Glu Leu
                245                 250                 255
Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly Gly
            260                 265                 270
Gly Gly Gly Ser Gly Gly Gly Gly Ser His Glu Gln Cys Arg Pro Trp
        275                 280                 285
Arg Lys Asn Ala Cys Cys Ser Thr Asn Thr Ser Gln Gly Gly Gly Gly
    290                 295                 300
Ser Gly Gly Gly Gly Ser Ala His Lys Asp Val Ser Tyr Leu Tyr Arg
305                 310                 315                 320
Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Gly Gly Gly Gly
                325                 330                 335
Ser Gly Gly Gly Gly Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln Val
            340                 345                 350
Asp Gln Ser Trp Arg Lys Glu Arg Val Leu Asn Gly Gly Gly Gly Ser
        355                 360                 365
Gly Gly Gly Gly Ser Ala Gly Pro Trp Ala Ala Trp Pro Phe Leu Leu
    370                 375                 380
Ser Leu Ala Leu Met Leu Leu Trp Leu Leu Ser Ser Arg Tyr Thr Asp
385                 390                 395                 400
Ile Glu Met Asn Arg Leu Gly Lys
                405

<210> 55
<211> 403
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-PAA Folate Receptor Alpha Class II with VSVG
      secretion trafficking

<400> 55
Leu Gly Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg
 1               5                  10                  15
Gly Arg Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg
            20                  25                  30
Gly Ser Arg Pro Gly Pro Ala Gly Thr Lys Cys Leu Leu Tyr Leu Ala
        35                  40                  45
Phe Leu Phe Ile Gly Val Asn Cys Lys Phe Tyr Pro Ser Tyr His Ser
    50                  55                  60
Thr Pro Gln Arg Pro Phe Thr Ile Leu Phe Pro His Asn Gln Lys Gly
65                  70                  75                  80
Asn Trp Lys Asn Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser
                85                  90                  95
Asp Leu Asn Trp His Asn Asp Leu Ile Gly Thr Ala Ile Gln Val Lys
            100                 105                 110
Met Pro Lys Ser His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His
        115                 120                 125
Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys
    130                 135                 140
Tyr Ile Thr Gln Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys
145                 150                 155                 160
Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly
                165                 170                 175
Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala
            180                 185                 190
Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr
        195                 200                 205
Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr
    210                 215                 220
Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys
225                 230                 235                 240
Val Lys Gly Ser Arg Trp Ala Arg Thr Glu Leu Leu Asn Val Cys Met
                245                 250                 255
Asn Ala Lys His His Lys Glu Lys Pro Gly Gly Gly Gly Gly Ser Gly
            260                 265                 270
Gly Gly Gly Ser His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala Cys
        275                 280                 285
Cys Ser Thr Asn Thr Ser Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly
    290                 295                 300
Ser Ala His Lys Asp Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn His
305                 310                 315                 320
Cys Gly Glu Met Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly
                325                 330                 335
Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg
            340                 345                 350
Lys Glu Arg Val Leu Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        355                 360                 365
Ala Gly Pro Trp Ala Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met
    370                 375                 380
Leu Leu Trp Leu Leu Ser Ser Arg Tyr Thr Asp Ile Glu Met Asn Arg
385                 390                 395                 400
Leu Gly Lys


<210> 56
<211> 201
<212> PRT
<213> Artificial Sequence

<220> 
<223> VSVG membrane localization signal

<400> 56
Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr Leu Ala Pro Lys Asn Pro
 1               5                  10                  15
Gly Thr Gly Pro Val Phe Thr Ile Ile Asn Gly Thr Leu Lys Tyr Phe
            20                  25                  30
Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala Ala Pro Ile Leu Ser Arg
        35                  40                  45
Met Val Gly Met Ile Ser Gly Thr Thr Thr Glu Arg Glu Leu Trp Asp
    50                  55                  60
Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile Gly Pro Asn Gly Val Leu
65                  70                  75                  80
Arg Thr Ser Leu Gly Tyr Lys Phe Pro Leu Tyr Met Ile Gly His Gly
                85                  90                  95
Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu
            100                 105                 110
His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Thr
        115                 120                 125
Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Phe Val
    130                 135                 140
Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe
145                 150                 155                 160
Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile
                165                 170                 175
Tyr Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr
            180                 185                 190
Asp Ile Glu Met Asn Arg Leu Gly Lys
        195                 200

<210> 57
<211> 606
<212> DNA
<213> Artificial Sequence

<220> 
<223> VSVG membrane localization signal

<400> 57
cttcccatct ctccagtgga tctcagctat cttgctccta aaaacccagg aaccggtcct      60
gtctttacca taatcaatgg taccctaaaa tactttgaga ccagatacat cagagtcgat     120
attgctgctc caatcctctc aagaatggtc ggaatgatca gtggaactac cacagaaagg     180
gaactgtggg atgactgggc tccatatgaa gacgtggaaa ttggacccaa tggagttctg     240
aggaccagtt taggatataa gtttccttta tatatgattg gacatggtat gttggactcc     300
gatcttcatc ttagctcaaa ggctcaggtg tttgaacatc ctcacattca agacgctgct     360
tcgcagcttc ctgatgatga gactttattt tttggtgata ctgggctatc caaaaatcca     420
atcgagtttg tagaaggttg gttcagtagt tggaagagct ctattgcctc ttttttcttt     480
atcatagggt taatcattgg actattcttg gttctccgag ttggtattta tctttgcatt     540
aaattaaagc acaccaagaa aagacagatt tatacagaca tagagatgaa ccgacttgga     600
aagtaa                                                                606

<210> 58
<211> 2067
<212> DNA
<213> Artificial Sequence

<220> 
<223> MTI-PAA Folate Receptor Alpha Class II with VSVG
      membrane localization

<400> 58
atcgaggtta acgtttaaac gggtggagat gtagaagatg tgacgccgcg gcccggcggg      60
tgccagatta gcggacgcgg tgcccgcggt tgcaacggga tcccgggcgc tgcagcttgg     120
gaggcggctc tccccaggcg gcgtccgcgg agacacccat ccgtgaaccc caggtcccgg     180
gccgccggct cgccgcgcac caggggccgg cggacagaag agcggccgag cggctcgagg     240
ctgggggacc gcgggcgcgg ccgcgcgctg ccgggcggga ggctgggggg ccggggccgg     300
ggccgtgccc cggagcgggt cggaggccgg ggccggggcc gggggacggc ggctccccgc     360
gcggctccag cggctcgggg atcccggccg ggccccgcag ggaccaagtg ccttttgtac     420
ttagcctttt tattcattgg ggtgaattgc aagttttacc cttcttatca ctctacccca     480
cagcggccta agttcaccat actttttcca cacaaccaaa aaggaaactg gaaaaatgtt     540
ccttctaatt accattattg cccgtcaagc tcagatttaa attggcataa tgacttaata     600
ggcacagcca tacaagtcaa aatgcccaag agtcacaagg ctattcaagc agacggttgg     660
atgtgtcatg cttccaaatg ggtcactact tgtgatttcc gctggtatgg accgaagtat     720
ataacacagt ccatccgatc cttcactcca tctgtagaac aatgcaagga aagcattgaa     780
caaacgaaac aaggaacttg gctgaatcca ggcttccctc ctcaaagttg tggatatgca     840
actgtgacgg atgccgaagc agtgattgtc caggtgactc ctcaccatgt gctggttgat     900
gaatacacag gagaatgggt tgattcacag ttcatcaacg gaaaatgcag caattacata     960
tgccccactg tccataactc tacaacctgg cattctgact ataaggtcaa agggtctaga    1020
tgggccagaa ccgagctgct gaacgtgtgc atgaacgcca agcaccacaa ggagaagccc    1080
ggcggcggcg gcggcagcgg cggcggcggc agccacgagc agtgcagacc ctggagaaag    1140
aacgcctgct gcagcaccaa caccagccag ggcggcggcg gcagcggcgg cggcggcagc    1200
gcccacaagg acgtgagcta cctgtacaga ttcaactgga accactgcgg cgagatggcc    1260
cccgccggcg gcggcggcag cggcggcggc ggcagcccca acctgggccc ctggatccag    1320
caggtggacc agagctggag aaaggagaga gtgctgaacg gcggcggcgg cagcggcggc    1380
ggcggcagcg ccggcccctg ggccgcctgg cccttcctgc tgagcctggc cctgatgctg    1440
ctgtggctgc tgagctctag acttcccatc tctccagtgg atctcagcta tcttgctcct    1500
aaaaacccag gaaccggtcc tgtctttacc ataatcaatg gtaccctaaa atactttgag    1560
accagataca tcagagtcga tattgctgct ccaatcctct caagaatggt cggaatgatc    1620
agtggaacta ccacagaaag ggaactgtgg gatgactggg ctccatatga agacgtggaa    1680
attggaccca atggagttct gaggaccagt ttaggatata agtttccttt atatatgatt    1740
ggacatggta tgttggactc cgatcttcat cttagctcaa aggctcaggt gtttgaacat    1800
cctcacattc aagacgctgc ttcgcagctt cctgatgatg agactttatt ttttggtgat    1860
actgggctat ccaaaaatcc aatcgagttt gtagaaggtt ggttcagtag ttggaagagc    1920
tctattgcct cttttttctt tatcataggg ttaatcattg gactattctt ggttctccga    1980
gttggtattt atctttgcat taaattaaag cacaccaaga aaagacagat ttatacagac    2040
atagagatga accgacttgg aaagtaa                                        2067

<210> 59
<211> 608
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-PAA Folate Receptor Alpha Class II with VSVG
      membrane localization and secretion trafficking

<400> 59
Met Gly Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly
 1               5                  10                  15
Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg
            20                  25                  30
Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser
        35                  40                  45
Arg Pro Gly Pro Ala Gly Thr Lys Cys Leu Leu Tyr Leu Ala Phe Leu
    50                  55                  60
Phe Ile Gly Val Asn Cys Lys Phe Tyr Pro Ser Tyr His Ser Thr Pro
65                  70                  75                  80
Gln Arg Pro Lys Phe Thr Ile Leu Phe Pro His Asn Gln Lys Gly Asn
                85                  90                  95
Trp Lys Asn Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp
            100                 105                 110
Leu Asn Trp His Asn Asp Leu Ile Gly Thr Ala Ile Gln Val Lys Met
        115                 120                 125
Pro Lys Ser His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala
    130                 135                 140
Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr
145                 150                 155                 160
Ile Thr Gln Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys
                165                 170                 175
Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe
            180                 185                 190
Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val
        195                 200                 205
Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly
    210                 215                 220
Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile
225                 230                 235                 240
Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val
                245                 250                 255
Lys Gly Ser Arg Trp Ala Arg Thr Glu Leu Leu Asn Val Cys Met Asn
            260                 265                 270
Ala Lys His His Lys Glu Lys Pro Gly Gly Gly Gly Gly Ser Gly Gly
        275                 280                 285
Gly Gly Ser His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala Cys Cys
    290                 295                 300
Ser Thr Asn Thr Ser Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
305                 310                 315                 320
Ala His Lys Asp Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn His Cys
                325                 330                 335
Gly Glu Met Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
            340                 345                 350
Pro Asn Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys
        355                 360                 365
Glu Arg Val Leu Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala
    370                 375                 380
Gly Pro Trp Ala Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu
385                 390                 395                 400
Leu Trp Leu Leu Ser Ser Arg Leu Pro Ile Ser Pro Val Asp Leu Ser
                405                 410                 415
Tyr Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Val Phe Thr Ile Ile
            420                 425                 430
Asn Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile
        435                 440                 445
Ala Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr
    450                 455                 460
Thr Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu
465                 470                 475                 480
Ile Gly Pro Asn Gly Val Leu Arg Thr Ser Leu Gly Tyr Lys Phe Pro
                485                 490                 495
Leu Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser
            500                 505                 510
Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser
        515                 520                 525
Gln Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly Asp Thr Gly Leu Ser
    530                 535                 540
Lys Asn Pro Ile Glu Phe Val Glu Gly Trp Phe Ser Ser Trp Lys Ser
545                 550                 555                 560
Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe
                565                 570                 575
Leu Val Leu Arg Val Gly Ile Tyr Leu Cys Ile Lys Leu Lys His Thr
            580                 585                 590
Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys
        595                 600                 605

<210> 60
<211> 599
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-PAA Folate Receptor Alpha Class II with VSVG
      membrane localization and secretion trafficking

<400> 60
Leu Pro Gly Gly Arg Leu Gly Gly Arg Gly Arg Gly Arg Ala Pro Glu
 1               5                  10                  15
Arg Val Gly Gly Arg Gly Arg Gly Arg Gly Thr Ala Ala Pro Arg Ala
            20                  25                  30
Ala Pro Ala Ala Arg Gly Ser Arg Pro Gly Pro Ala Gly Thr Lys Cys
        35                  40                  45
Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys Lys Phe Tyr
    50                  55                  60
Pro Ser Tyr His Ser Thr Pro Gln Arg Pro Lys Phe Thr Ile Leu Phe
65                  70                  75                  80
Pro His Asn Gln Lys Gly Asn Trp Lys Asn Val Pro Ser Asn Tyr His
                85                  90                  95
Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp His Asn Asp Leu Ile Gly
            100                 105                 110
Thr Ala Ile Gln Val Lys Met Pro Lys Ser His Lys Ala Ile Gln Ala
        115                 120                 125
Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe
    130                 135                 140
Arg Trp Tyr Gly Pro Lys Tyr Ile Thr Gln Ser Ile Arg Ser Phe Thr
145                 150                 155                 160
Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly
                165                 170                 175
Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr
            180                 185                 190
Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His His Val
        195                 200                 205
Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn
    210                 215                 220
Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr
225                 230                 235                 240
Trp His Ser Asp Tyr Lys Val Lys Gly Ser Arg Trp Ala Arg Thr Glu
                245                 250                 255
Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly
            260                 265                 270
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Glu Gln Cys Arg Pro
        275                 280                 285
Trp Arg Lys Asn Ala Cys Cys Ser Thr Asn Thr Ser Gln Gly Gly Gly
    290                 295                 300
Gly Ser Gly Gly Gly Gly Ser Ala His Lys Asp Val Ser Tyr Leu Tyr
305                 310                 315                 320
Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Gly Gly Gly
                325                 330                 335
Gly Ser Gly Gly Gly Gly Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln
            340                 345                 350
Val Asp Gln Ser Trp Arg Lys Glu Arg Val Leu Asn Gly Gly Gly Gly
        355                 360                 365
Ser Gly Gly Gly Gly Ser Ala Gly Pro Trp Ala Ala Trp Pro Phe Leu
    370                 375                 380
Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu Ser Ser Arg Leu Pro
385                 390                 395                 400
Ile Ser Pro Val Asp Leu Ser Tyr Leu Ala Pro Lys Asn Pro Gly Thr
                405                 410                 415
Gly Pro Val Phe Thr Ile Ile Asn Gly Thr Leu Lys Tyr Phe Glu Thr
            420                 425                 430
Arg Tyr Ile Arg Val Asp Ile Ala Ala Pro Ile Leu Ser Arg Met Val
        435                 440                 445
Gly Met Ile Ser Gly Thr Thr Thr Glu Arg Glu Leu Trp Asp Asp Trp
    450                 455                 460
Ala Pro Tyr Glu Asp Val Glu Ile Gly Pro Asn Gly Val Leu Arg Thr
465                 470                 475                 480
Ser Leu Gly Tyr Lys Phe Pro Leu Tyr Met Ile Gly His Gly Met Leu
                485                 490                 495
Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro
            500                 505                 510
His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Thr Leu Phe
        515                 520                 525
Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Phe Val Glu Gly
    530                 535                 540
Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile
545                 550                 555                 560
Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile Tyr Leu
                565                 570                 575
Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile
            580                 585                 590
Glu Met Asn Arg Leu Gly Lys
        595

<210> 61
<211> 594
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-PAA Folate Receptor Alpha Class II with VSVG
      membrane localization and secretion trafficking

<400> 61
Leu Gly Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg
 1               5                  10                  15
Gly Arg Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg
            20                  25                  30
Gly Ser Arg Pro Gly Pro Ala Gly Thr Lys Cys Leu Leu Tyr Leu Ala
        35                  40                  45
Phe Leu Phe Ile Gly Val Asn Cys Lys Phe Tyr Pro Ser Tyr His Ser
    50                  55                  60
Thr Pro Gln Arg Pro Lys Phe Thr Ile Leu Phe Pro His Asn Gln Lys
65                  70                  75                  80
Gly Asn Trp Lys Asn Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser
                85                  90                  95
Ser Asp Leu Asn Trp His Asn Asp Leu Ile Gly Thr Ala Ile Gln Val
            100                 105                 110
Lys Met Pro Lys Ser His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys
        115                 120                 125
His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro
    130                 135                 140
Lys Tyr Ile Thr Gln Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln
145                 150                 155                 160
Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro
                165                 170                 175
Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu
            180                 185                 190
Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr
        195                 200                 205
Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn
    210                 215                 220
Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr
225                 230                 235                 240
Lys Val Lys Gly Ser Arg Trp Ala Arg Thr Glu Leu Leu Asn Val Cys
                245                 250                 255
Met Asn Ala Lys His His Lys Glu Lys Pro Gly Gly Gly Gly Gly Ser
            260                 265                 270
Gly Gly Gly Gly Ser His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala
        275                 280                 285
Cys Cys Ser Thr Asn Thr Ser Gln Gly Gly Gly Gly Ser Gly Gly Gly
    290                 295                 300
Gly Ser Ala His Lys Asp Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn
305                 310                 315                 320
His Cys Gly Glu Met Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly
                325                 330                 335
Gly Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp
            340                 345                 350
Arg Lys Glu Arg Val Leu Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly
        355                 360                 365
Ser Ala Gly Pro Trp Ala Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu
    370                 375                 380
Met Leu Leu Trp Leu Leu Ser Ser Arg Leu Pro Ile Ser Pro Val Asp
385                 390                 395                 400
Leu Ser Tyr Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Val Phe Thr
                405                 410                 415
Ile Ile Asn Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val
            420                 425                 430
Asp Ile Ala Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly
        435                 440                 445
Thr Thr Thr Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp
    450                 455                 460
Val Glu Ile Gly Pro Asn Gly Val Leu Arg Thr Ser Leu Gly Tyr Lys
465                 470                 475                 480
Phe Pro Leu Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His
                485                 490                 495
Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala
            500                 505                 510
Ala Ser Gln Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly Asp Thr Gly
        515                 520                 525
Leu Ser Lys Asn Pro Ile Glu Phe Val Glu Gly Trp Phe Ser Ser Trp
    530                 535                 540
Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly
545                 550                 555                 560
Leu Phe Leu Val Leu Arg Val Gly Ile Tyr Leu Cys Ile Lys Leu Lys
                565                 570                 575
His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu
            580                 585                 590
Gly Lys


<210> 62
<211> 433
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-PAA Folate Receptor Alpha Class II with VSVG
      membrane localization

<400> 62
Met Gly Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly
 1               5                  10                  15
Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg
            20                  25                  30
Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser
        35                  40                  45
Arg Pro Gly Pro Ala Gly Thr Lys Cys Leu Leu Tyr Leu Ala Phe Leu
    50                  55                  60
Phe Ile Gly Val Asn Cys Lys Phe Tyr Pro Ser Tyr His Ser Thr Pro
65                  70                  75                  80
Gln Arg Pro Ser Arg Trp Ala Arg Thr Glu Leu Leu Asn Val Cys Met
                85                  90                  95
Asn Ala Lys His His Lys Glu Lys Pro Gly Gly Gly Gly Gly Ser Gly
            100                 105                 110
Gly Gly Gly Ser His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala Cys
        115                 120                 125
Cys Ser Thr Asn Thr Ser Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly
    130                 135                 140
Ser Ala His Lys Asp Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn His
145                 150                 155                 160
Cys Gly Glu Met Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly
                165                 170                 175
Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg
            180                 185                 190
Lys Glu Arg Val Leu Asn Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        195                 200                 205
Ala Gly Pro Trp Ala Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met
    210                 215                 220
Leu Leu Trp Leu Leu Ser Ser Arg Leu Pro Ile Ser Pro Val Asp Leu
225                 230                 235                 240
Ser Tyr Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Val Phe Thr Ile
                245                 250                 255
Ile Asn Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp
            260                 265                 270
Ile Ala Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr
        275                 280                 285
Thr Thr Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val
    290                 295                 300
Glu Ile Gly Pro Asn Gly Val Leu Arg Thr Ser Leu Gly Tyr Lys Phe
305                 310                 315                 320
Pro Leu Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu
                325                 330                 335
Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala
            340                 345                 350
Ser Gln Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly Asp Thr Gly Leu
        355                 360                 365
Ser Lys Asn Pro Ile Glu Phe Val Glu Gly Trp Phe Ser Ser Trp Lys
    370                 375                 380
Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu
385                 390                 395                 400
Phe Leu Val Leu Arg Val Gly Ile Tyr Leu Cys Ile Lys Leu Lys His
                405                 410                 415
Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly
            420                 425                 430
Lys


<210> 63
<211> 424
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-PAA Folate Receptor Alpha Class II with VSVG
      membrane localization

<400> 63
Leu Pro Gly Gly Arg Leu Gly Gly Arg Gly Arg Gly Arg Ala Pro Glu
 1               5                  10                  15
Arg Val Gly Gly Arg Gly Arg Gly Arg Gly Thr Ala Ala Pro Arg Ala
            20                  25                  30
Ala Pro Ala Ala Arg Gly Ser Arg Pro Gly Pro Ala Gly Thr Lys Cys
        35                  40                  45
Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys Lys Phe Tyr
    50                  55                  60
Pro Ser Tyr His Ser Thr Pro Gln Arg Pro Ser Arg Trp Ala Arg Thr
65                  70                  75                  80
Glu Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro
                85                  90                  95
Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Glu Gln Cys Arg
            100                 105                 110
Pro Trp Arg Lys Asn Ala Cys Cys Ser Thr Asn Thr Ser Gln Gly Gly
        115                 120                 125
Gly Gly Ser Gly Gly Gly Gly Ser Ala His Lys Asp Val Ser Tyr Leu
    130                 135                 140
Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Gly Gly
145                 150                 155                 160
Gly Gly Ser Gly Gly Gly Gly Ser Pro Asn Leu Gly Pro Trp Ile Gln
                165                 170                 175
Gln Val Asp Gln Ser Trp Arg Lys Glu Arg Val Leu Asn Gly Gly Gly
            180                 185                 190
Gly Ser Gly Gly Gly Gly Ser Ala Gly Pro Trp Ala Ala Trp Pro Phe
        195                 200                 205
Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu Ser Ser Arg Leu
    210                 215                 220
Pro Ile Ser Pro Val Asp Leu Ser Tyr Leu Ala Pro Lys Asn Pro Gly
225                 230                 235                 240
Thr Gly Pro Val Phe Thr Ile Ile Asn Gly Thr Leu Lys Tyr Phe Glu
                245                 250                 255
Thr Arg Tyr Ile Arg Val Asp Ile Ala Ala Pro Ile Leu Ser Arg Met
            260                 265                 270
Val Gly Met Ile Ser Gly Thr Thr Thr Glu Arg Glu Leu Trp Asp Asp
        275                 280                 285
Trp Ala Pro Tyr Glu Asp Val Glu Ile Gly Pro Asn Gly Val Leu Arg
    290                 295                 300
Thr Ser Leu Gly Tyr Lys Phe Pro Leu Tyr Met Ile Gly His Gly Met
305                 310                 315                 320
Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His
                325                 330                 335
Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Thr Leu
            340                 345                 350
Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Phe Val Glu
        355                 360                 365
Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile
    370                 375                 380
Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile Tyr
385                 390                 395                 400
Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp
                405                 410                 415
Ile Glu Met Asn Arg Leu Gly Lys
            420

<210> 64
<211> 419
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-PAA Folate Receptor Alpha Class II with VSVG
      membrane localization

<400> 64
Leu Gly Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg
 1               5                  10                  15
Gly Arg Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg
            20                  25                  30
Gly Ser Arg Pro Gly Pro Ala Gly Thr Lys Cys Leu Leu Tyr Leu Ala
        35                  40                  45
Phe Leu Phe Ile Gly Val Asn Cys Lys Phe Tyr Pro Ser Tyr His Ser
    50                  55                  60
Thr Pro Gln Arg Pro Ser Arg Trp Ala Arg Thr Glu Leu Leu Asn Val
65                  70                  75                  80
Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly Gly Gly Gly Gly
                85                  90                  95
Ser Gly Gly Gly Gly Ser His Glu Gln Cys Arg Pro Trp Arg Lys Asn
            100                 105                 110
Ala Cys Cys Ser Thr Asn Thr Ser Gln Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125
Gly Gly Ser Ala His Lys Asp Val Ser Tyr Leu Tyr Arg Phe Asn Trp
    130                 135                 140
Asn His Cys Gly Glu Met Ala Pro Ala Gly Gly Gly Gly Ser Gly Gly
145                 150                 155                 160
Gly Gly Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser
                165                 170                 175
Trp Arg Lys Glu Arg Val Leu Asn Gly Gly Gly Gly Ser Gly Gly Gly
            180                 185                 190
Gly Ser Ala Gly Pro Trp Ala Ala Trp Pro Phe Leu Leu Ser Leu Ala
        195                 200                 205
Leu Met Leu Leu Trp Leu Leu Ser Ser Arg Leu Pro Ile Ser Pro Val
    210                 215                 220
Asp Leu Ser Tyr Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Val Phe
225                 230                 235                 240
Thr Ile Ile Asn Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg
                245                 250                 255
Val Asp Ile Ala Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser
            260                 265                 270
Gly Thr Thr Thr Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu
        275                 280                 285
Asp Val Glu Ile Gly Pro Asn Gly Val Leu Arg Thr Ser Leu Gly Tyr
    290                 295                 300
Lys Phe Pro Leu Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu
305                 310                 315                 320
His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp
                325                 330                 335
Ala Ala Ser Gln Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly Asp Thr
            340                 345                 350
Gly Leu Ser Lys Asn Pro Ile Glu Phe Val Glu Gly Trp Phe Ser Ser
        355                 360                 365
Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile
    370                 375                 380
Gly Leu Phe Leu Val Leu Arg Val Gly Ile Tyr Leu Cys Ile Lys Leu
385                 390                 395                 400
Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg
                405                 410                 415
Leu Gly Lys


<210> 65
<211> 1147
<212> DNA
<213> Homo sapiens

<400> 65
tggaggcctg gctggtgctc acatacaata attaactgct gagtggcctt cgcccaatcc      60
caggctccac tcctgggctc cattcccact ccctgcctgt ctcctaggcc actaaaccac     120
agctgtcccc tggaataagg caagggggag tgtagagcag agcagaagcc tgagccagac     180
ggagagccac ctcctctccc agggacagac atggctcagc ggatgacaac acagctgctg     240
ctccttctag tgtgggtggc tgtagtaggg gaggctcaga caaggattgc atgggccagg     300
actgagcttc tcaatgtctg catgaacgcc aagcaccaca aggaaaagcc aggccccgag     360
gacaagttgc atgagcagtg tcgaccctgg aggaagaatg cctgctgttc taccaacacc     420
agccaggaag cccataagga tgtttcctac ctatatagat tcaactggaa ccactgtgga     480
gagatggcac ctgcctgcaa acggcatttc atccaggaca cctgcctcta cgagtgctcc     540
cccaacttgg ggccctggat ccagcaggtg gatcagagct ggcgcaaaga gcgggtactg     600
aacgtgcccc tgtgcaaaga ggactgtgag caatggtggg aagattgtcg cacctcctac     660
acctgcaaga gcaactggca caagggctgg aactggactt cagggtttaa caagtgcgca     720
gtgggagctg cctgccaacc tttccatttc tacttcccca cacccactgt tctgtgcaat     780
gaaatctgga ctcactccta caaggtcagc aactacagcc gagggagtgg ccgctgcatc     840
cagatgtggt tcgacccagc ccagggcaac cccaatgagg aggtggcgag gttctatgct     900
gcagccatga gtggggctgg gccctgggca gcctggcctt tcctgcttag cctggcccta     960
atgctgctgt ggctgctcag ctgacctcct tttaccttct gatacctgga aatccctgcc    1020
ctgttcagcc ccacagctcc caactatttg gttcctgctc catggtcggg cctctgacag    1080
ccactttgaa taaaccagac accgcacatg tgtcttgaga attatttgga aaaaaaaaaa    1140
aaaaaaa                                                              1147

<210> 66
<211> 257
<212> PRT
<213> Homo sapiens

<400> 66
Met Ala Gln Arg Met Thr Thr Gln Leu Leu Leu Leu Leu Val Trp Val
 1               5                  10                  15
Ala Val Val Gly Glu Ala Gln Thr Arg Ile Ala Trp Ala Arg Thr Glu
            20                  25                  30
Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu Lys Pro Gly
        35                  40                  45
Pro Glu Asp Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala
    50                  55                  60
Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala His Lys Asp Val Ser Tyr
65                  70                  75                  80
Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala Pro Ala Cys
                85                  90                  95
Lys Arg His Phe Ile Gln Asp Thr Cys Leu Tyr Glu Cys Ser Pro Asn
            100                 105                 110
Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg
        115                 120                 125
Val Leu Asn Val Pro Leu Cys Lys Glu Asp Cys Glu Gln Trp Trp Glu
    130                 135                 140
Asp Cys Arg Thr Ser Tyr Thr Cys Lys Ser Asn Trp His Lys Gly Trp
145                 150                 155                 160
Asn Trp Thr Ser Gly Phe Asn Lys Cys Ala Val Gly Ala Ala Cys Gln
                165                 170                 175
Pro Phe His Phe Tyr Phe Pro Thr Pro Thr Val Leu Cys Asn Glu Ile
            180                 185                 190
Trp Thr His Ser Tyr Lys Val Ser Asn Tyr Ser Arg Gly Ser Gly Arg
        195                 200                 205
Cys Ile Gln Met Trp Phe Asp Pro Ala Gln Gly Asn Pro Asn Glu Glu
    210                 215                 220
Val Ala Arg Phe Tyr Ala Ala Ala Met Ser Gly Ala Gly Pro Trp Ala
225                 230                 235                 240
Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu Leu
                245                 250                 255
Ser


<210> 67
<211> 182
<212> PRT
<213> Artificial Sequence

<220> 
<223> Folate Receptor Alpha PAA - Class II embedded
      class I

<400> 67
Ile Ala Trp Ala Arg Thr Glu Leu Leu Asn Val Cys Met Asn Ala Lys
 1               5                  10                  15
His His Lys Glu Lys Pro Gly Pro Glu Gly Gly Gly Gly Ser Gly Gly
            20                  25                  30
Gly Gly Ser Gly Gly Gly Gly Ser Lys Leu His Glu Gln Cys Arg Pro
        35                  40                  45
Trp Arg Lys Asn Ala Cys Cys Ser Thr Asn Thr Ser Gln Glu Ala Gly
    50                  55                  60
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Glu
65                  70                  75                  80
Ala His Lys Asp Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn His Cys
                85                  90                  95
Gly Glu Met Ala Pro Ala Cys Lys Gly Gly Gly Gly Ser Gly Gly Gly
            100                 105                 110
Gly Ser Gly Gly Gly Gly Ser Cys Ser Pro Asn Leu Gly Pro Trp Ile
        115                 120                 125
Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg Val Leu Asn Val Pro
    130                 135                 140
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
145                 150                 155                 160
Ala Gly Pro Trp Ala Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met
                165                 170                 175
Leu Leu Trp Leu Leu Ser
            180

<210> 68
<211> 144
<212> PRT
<213> Artificial Sequence

<220> 
<223> Folate Receptor Alpha PAA - Class II embedded
      class I

<400> 68
Arg Thr Glu Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu
 1               5                  10                  15
Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
            20                  25                  30
Gln Cys Arg Pro Trp Arg Lys Asn Ala Cys Cys Ser Thr Asn Thr Gly
        35                  40                  45
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Asp
    50                  55                  60
Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu Met Ala
65                  70                  75                  80
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu
                85                  90                  95
Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg Val
            100                 105                 110
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Pro Trp
        115                 120                 125
Ala Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu Trp Leu
    130                 135                 140

<210> 69
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Folate Receptor Alpha PAA - Class II embedded
      class I

<400> 69
Ile Ala Trp Ala Arg Thr Glu Leu Leu Asn Val Cys Met Asn Ala Lys
 1               5                  10                  15
His His Lys Glu Lys Pro Gly Pro Glu
            20                  25

<210> 70
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Folate Receptor Alpha PAA - Class II embedded
      class I

<400> 70
Lys Leu His Glu Gln Cys Arg Pro Trp Arg Lys Asn Ala Cys Cys Ser
 1               5                  10                  15
Thr Asn Thr Ser Gln Glu Ala
            20

<210> 71
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Folate Receptor Alpha PAA - Class II embedded
      class I

<400> 71
Gln Glu Ala His Lys Asp Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn
 1               5                  10                  15
His Cys Gly Glu Met Ala Pro Ala Cys Lys
            20                  25

<210> 72
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> Folate Receptor Alpha PAA - Class II embedded
      class I

<400> 72
Cys Ser Pro Asn Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp
 1               5                  10                  15
Arg Lys Glu Arg Val Leu Asn Val Pro
            20                  25

<210> 73
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Folate Receptor Alpha PAA - Class II embedded
      class I

<400> 73
Ser Gly Ala Gly Pro Trp Ala Ala Trp Pro Phe Leu Leu Ser Leu Ala
 1               5                  10                  15
Leu Met Leu Leu Trp Leu Leu Ser
            20

<210> 74
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HLA Class II Folate Receptor Alpha

<400> 74
Arg Thr Glu Leu Leu Asn Val Cys Met Asn Ala Lys His His Lys Glu
 1               5                  10                  15
Lys


<210> 75
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> HLA Class II Folate Receptor Alpha

<400> 75
Gln Cys Arg Pro Trp Arg Lys Asn Ala Cys Cys Ser Thr Asn Thr
 1               5                  10                  15

<210> 76
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> HLA Class II Folate Receptor Alpha

<400> 76
Lys Asp Val Ser Tyr Leu Tyr Arg Phe Asn Trp Asn His Cys Gly Glu
 1               5                  10                  15
Met Ala


<210> 77
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> HLA Class II Folate Receptor Alpha

<400> 77
Leu Gly Pro Trp Ile Gln Gln Val Asp Gln Ser Trp Arg Lys Glu Arg
 1               5                  10                  15
Val


<210> 78
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> HLA Class II Folate Receptor Alpha

<400> 78
Pro Trp Ala Ala Trp Pro Phe Leu Leu Ser Leu Ala Leu Met Leu Leu
 1               5                  10                  15
Trp Leu


<210> 79
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide folate receptor
      alpha

<400> 79
Leu Leu Asn Val Cys Met Asn Ala Lys
 1               5

<210> 80
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide folate receptor
      alpha

<400> 80
Arg Pro Trp Arg Lys Asn Ala Cys Cys
 1               5

<210> 81
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide folate receptor
      alpha

<400> 81
Val Ser Tyr Leu Tyr Arg Phe Asn Trp
 1               5

<210> 82
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide folate receptor
      alpha

<400> 82
Gln Gln Val Asp Gln Ser Trp Arg Lys
 1               5

<210> 83
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide folate receptor
      alpha

<400> 83
Trp Ile Gln Gln Val Asp Gln Ser Trp
 1               5

<210> 84
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide folate receptor
      alpha

<400> 84
Phe Leu Leu Ser Leu Ala Leu Met Leu
 1               5

<210> 85
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide folate receptor
      alpha

<400> 85
Ala Ala Trp Pro Phe Leu Leu Ser Leu
 1               5

<210> 86
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide folate receptor
      alpha

<400> 86
Ser Leu Ala Leu Met Leu Leu Trp Leu
 1               5

<210> 87
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide folate receptor
      alpha

<400> 87
Leu Leu Ser Leu Ala Leu Met Leu Leu
 1               5

<210> 88
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide folate receptor
      alpha

<400> 88
Pro Trp Ala Ala Trp Pro Phe Leu Leu
 1               5

<210> 89
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide folate receptor
      alpha

<400> 89
Trp Pro Phe Leu Leu Ser Leu Ala Leu
 1               5

<210> 90
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide folate receptor
      alpha

<400> 90
Ala Ala Trp Pro Phe Leu Leu Ser Leu
 1               5

<210> 91
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide folate receptor
      alpha

<400> 91
Trp Pro Phe Leu Leu Ser Leu Ala Leu
 1               5

<210> 92
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide folate receptor
      alpha

<400> 92
Phe Leu Leu Ser Leu Ala Leu Met Leu
 1               5

<210> 93
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide folate receptor
      alpha

<400> 93
Leu Ser Leu Ala Leu Met Leu Leu Trp
 1               5

<210> 94
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> VSVG tag

<400> 94
Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys
 1               5                  10

<210> 95
<211> 426
<212> DNA
<213> Artificial Sequence

<220> 
<223> PolyStart with XbaI site

<400> 95
atcgaggtta acgtttaaac gggtggagat gtagaagatg tgacgccgcg gcccggcggg      60
tgccagatta gcggacgcgg tgcccgcggt tgcaacggga tcccgggcgc tgcagcttgg     120
gaggcggctc tccccaggcg gcgtccgcgg agacacccat ccgtgaaccc caggtcccgg     180
gccgccggct cgccgcgcac caggggccgg cggacagaag agcggccgag cggctcgagg     240
ctgggggacc gcgggcgcgg ccgcgcgctg ccgggcggga ggctgggggg ccggggccgg     300
ggccgtgccc cggagcgggt cggaggccgg ggccggggcc gggggacggc ggctccccgc     360
gcggctccag cggctcgggg atcccggccg ggccccgcag ggaccatggc agccgggagc     420
tctaga                                                                426

<210> 96
<211> 405
<212> DNA
<213> Artificial Sequence

<220> 
<223> PolyStart without XbaI site

<400> 96
atcgaggtta acgtttaaac gggtggagat gtagaagatg tgacgccgcg gcccggcggg      60
tgccagatta gcggacgcgg tgcccgcggt tgcaacggga tcccgggcgc tgcagcttgg     120
gaggcggctc tccccaggcg gcgtccgcgg agacacccat ccgtgaaccc caggtcccgg     180
gccgccggct cgccgcgcac caggggccgg cggacagaag agcggccgag cggctcgagg     240
ctgggggacc gcgggcgcgg ccgcgcgctg ccgggcggga ggctgggggg ccggggccgg     300
ggccgtgccc cggagcgggt cggaggccgg ggccggggcc gggggacggc ggctccccgc     360
gcggctccag cggctcgggg atcccggccg ggccccgcag ggacc                     405

<210> 97
<211> 558
<212> DNA
<213> Artificial Sequence

<220> 
<223> Folate Receptor Alpha PAA

<400> 97
tctagaatcg cctgggccag aaccgagctg ctgaacgtgt gcatgaacgc caagcaccac      60
aaggagaagc ccggccccga gggcggcggc ggcagcggcg gcggcggcag cggcggcggc     120
ggcagcaagc tgcacgagca gtgcagaccc tggagaaaga acgcctgctg cagcaccaac     180
accagccagg aggccggcgg cggcggcagc ggcggcggcg gcagcggcgg cggcggcagc     240
caggaggccc acaaggacgt gagctacctg tacagattca actggaacca ctgcggcgag     300
atggcccccg cctgcaaggg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc     360
agctgcagcc ccaacctggg cccctggatc cagcaggtgg accagagctg gagaaaggag     420
agagtgctga acgtgcccgg cggcggcggc agcggcggcg gcggcagcgg cggcggcggc     480
agcggcgccg gcccctgggc cgcctggccc ttcctgctga gcctggccct gatgctgctg     540
tggctgctga gctctaga                                                   558

<210> 98
<211> 546
<212> DNA
<213> Artificial Sequence

<220> 
<223> Folate Receptor Alpha PAA

<400> 98
atcgcctggg ccagaaccga gctgctgaac gtgtgcatga acgccaagca ccacaaggag      60
aagcccggcc ccgagggcgg cggcggcagc ggcggcggcg gcagcggcgg cggcggcagc     120
aagctgcacg agcagtgcag accctggaga aagaacgcct gctgcagcac caacaccagc     180
caggaggccg gcggcggcgg cagcggcggc ggcggcagcg gcggcggcgg cagccaggag     240
gcccacaagg acgtgagcta cctgtacaga ttcaactgga accactgcgg cgagatggcc     300
cccgcctgca agggcggcgg cggcagcggc ggcggcggca gcggcggcgg cggcagctgc     360
agccccaacc tgggcccctg gatccagcag gtggaccaga gctggagaaa ggagagagtg     420
ctgaacgtgc ccggcggcgg cggcagcggc ggcggcggca gcggcggcgg cggcagcggc     480
gccggcccct gggccgcctg gcccttcctg ctgagcctgg ccctgatgct gctgtggctg     540
ctgagc                                                                546

<210> 99
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> VSVG tag

<400> 99
tacaccgaca tcgagatgaa cagactgggc aag                                   33

<210> 100
<211> 979
<212> DNA
<213> Artificial Sequence

<220> 
<223> MTI-Folate Receptor Alpha PAA

<400> 100
gggtggagat gtagaagatg tgacgccgcg gcccggcggg tgccagatta gcggacgcgg      60
tgcccgcggt tgcaacggga tcccgggcgc tgcagcttgg gaggcggctc tccccaggcg     120
gcgtccgcgg agacacccat ccgtgaaccc caggtcccgg gccgccggct cgccgcgcac     180
caggggccgg cggacagaag agcggccgag cggctcgagg atgggggacc gcgggcgcgg     240
ccgcgcgctg ccgggcggga ggctgggggg ccggggccgg ggccgtgccc cggagcgggt     300
cggaggccgg ggccggggcc gggggacggc ggctccccgc gcggctccag cggctcgggg     360
atcccggccg ggccccgcag ggacctctag aatcgcctgg gccagaaccg agctgctgaa     420
cgtgtgcatg aacgccaagc accacaagga gaagcccggc cccgagggcg gcggcggcag     480
cggcggcggc ggcagcggcg gcggcggcag caagctgcac gagcagtgca gaccctggag     540
aaagaacgcc tgctgcagca ccaacaccag ccaggaggcc ggcggcggcg gcagcggcgg     600
cggcggcagc ggcggcggcg gcagccagga ggcccacaag gacgtgagct acctgtacag     660
attcaactgg aaccactgcg gcgagatggc ccccgcctgc aagggcggcg gcggcagcgg     720
cggcggcggc agcggcggcg gcggcagctg cagccccaac ctgggcccct ggatccagca     780
ggtggaccag agctggagaa aggagagagt gctgaacgtg cccggcggcg gcggcagcgg     840
cggcggcggc agcggcggcg gcggcagcgg cgccggcccc tgggccgcct ggcccttcct     900
gctgagcctg gccctgatgc tgctgtggct gctgagctct agatacaccg acatcgagat     960
gaacagactg ggcaagtaa                                                  979

<210> 101
<211> 1438
<212> DNA
<213> Homo sapiens

<400> 101
tgcggcggcg agggaggagg aagaagcgga ggaggcggct cccgcgctcg cagggccgtg      60
ccacctgccc gcccgcccgc tcgctcgctc gcccgccgcg ccgcgctgcc gaccgccagc     120
atgctgccga gagtgggctg ccccgcgctg ccgctgccgc cgccgccgct gctgccgctg     180
ctgccgctgc tgctgctgct actgggcgcg agtggcggcg gcggcggggc gcgcgcggag     240
gtgctgttcc gctgcccgcc ctgcacaccc gagcgcctgg ccgcctgcgg gcccccgccg     300
gttgcgccgc ccgccgcggt ggccgcagtg gccggggcgc ccgcatgcca tgcgcggagc     360
tcgtccggga gccgggctgc ggctgctgct cggtgtgcgc ccggctggag ggcgaggcgt     420
gcggcgtcta caccccgcgc tgcggccagg ggctgcgctg ctatccccac ccgggctccg     480
agctgcccct gcaggcgctg gtcatgggcg agggcacttg tgagaagcgc cgggacgccg     540
agtatggcgc cagcccggag caggttgcag acaatggcga tgaccactca gaaggaggcc     600
tggtggagaa ccacgtggac agcaccatga acatgttggg cgggggaggc agtgctggcc     660
ggaagcccct caagtcgggt atgaaggagc tggccgtgtt ccgggagaag gtcactgagc     720
agcaccggca gatgggcaag ggtggcaagc atcaccttgg cctggaggag cccaagaagc     780
tgcgaccacc ccctgccagg actccctgcc aacaggaact ggaccaggtc ctggagcgga     840
tctccaccat gcgccttccg gatgagcggg gccctctgga gcacctctac tccctgcaca     900
tccccaactg tgacaagcat ggcctgtaca acctcaaaca gtgcaagatg tctctgaacg     960
ggcagcgtgg ggagtgctgg tgtgtgaacc ccaacaccgg gaagctgatc cagggagccc    1020
ccaccatccg gggggacccc gagtgtcatc tcttctacaa tgagcagcag gaggctcgcg    1080
gggtgcacac ccagcggatg cagtagaccg cagccagccg gtgcctggcg cccctgcccc    1140
ccgcccctct ccaaacaccg gcagaaaacg gagagtgctt gggtggtggg tgctggagga    1200
ttttccagtt ctgacacacg tatttatatt tggaaagaga ccagcaccga gctcggcacc    1260
tccccggcct ctctcttccc agctgcagat gccacacctg ctccttcttg ctttccccgg    1320
gggaggaagg gggttgtggt cggggagctg gggtacaggt ttggggaggg ggaagagaaa    1380
tttttatttt tgaacccctg tgtccctttt gcataagatt aaaggaagga aaagtaaa      1438

<210> 102
<211> 328
<212> PRT
<213> Homo sapiens

<400> 102
Met Leu Pro Arg Val Gly Cys Pro Ala Leu Pro Leu Pro Pro Pro Pro
 1               5                  10                  15
Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly
            20                  25                  30
Gly Gly Gly Gly Ala Arg Ala Glu Val Leu Phe Arg Cys Pro Pro Cys
        35                  40                  45
Thr Pro Glu Arg Leu Ala Ala Cys Gly Pro Pro Pro Val Ala Pro Pro
    50                  55                  60
Ala Ala Val Ala Ala Val Ala Gly Gly Ala Arg Met Pro Cys Ala Glu
65                  70                  75                  80
Leu Val Arg Glu Pro Gly Cys Gly Cys Cys Ser Val Cys Ala Arg Leu
                85                  90                  95
Glu Gly Glu Ala Cys Gly Val Tyr Thr Pro Arg Cys Gly Gln Gly Leu
            100                 105                 110
Arg Cys Tyr Pro His Pro Gly Ser Glu Leu Pro Leu Gln Ala Leu Val
        115                 120                 125
Met Gly Glu Gly Thr Cys Glu Lys Arg Arg Asp Ala Glu Tyr Gly Ala
    130                 135                 140
Ser Pro Glu Gln Val Ala Asp Asn Gly Asp Asp His Ser Glu Gly Gly
145                 150                 155                 160
Leu Val Glu Asn His Val Asp Ser Thr Met Asn Met Leu Gly Gly Gly
                165                 170                 175
Gly Ser Ala Gly Arg Lys Pro Leu Lys Ser Gly Met Lys Glu Leu Ala
            180                 185                 190
Val Phe Arg Glu Lys Val Thr Glu Gln His Arg Gln Met Gly Lys Gly
        195                 200                 205
Gly Lys His His Leu Gly Leu Glu Glu Pro Lys Lys Leu Arg Pro Pro
    210                 215                 220
Pro Ala Arg Thr Pro Cys Gln Gln Glu Leu Asp Gln Val Leu Glu Arg
225                 230                 235                 240
Ile Ser Thr Met Arg Leu Pro Asp Glu Arg Gly Pro Leu Glu His Leu
                245                 250                 255
Tyr Ser Leu His Ile Pro Asn Cys Asp Lys His Gly Leu Tyr Asn Leu
            260                 265                 270
Lys Gln Cys Lys Met Ser Leu Asn Gly Gln Arg Gly Glu Cys Trp Cys
        275                 280                 285
Val Asn Pro Asn Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg
    290                 295                 300
Gly Asp Pro Glu Cys His Leu Phe Tyr Asn Glu Gln Gln Glu Ala Arg
305                 310                 315                 320
Gly Val His Thr Gln Arg Met Gln
                325

<210> 103
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II IFGFBP-2

<400> 103
Leu Leu Pro Leu Leu Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser
 1               5                  10                  15

<210> 104
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II IFGFBP-2

<400> 104
Pro Leu Leu Leu Leu Leu Leu Gly Ala Ser Gly Gly Gly Gly Gly
 1               5                  10                  15

<210> 105
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II IFGFBP-2

<400> 105
Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn
 1               5                  10                  15

<210> 106
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II IFGFBP-2

<400> 106
Thr Gly Lys Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro
 1               5                  10                  15

<210> 107
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I IGFBP-2

<400> 107
Leu Leu Pro Leu Leu Leu Leu Leu Leu
 1               5

<210> 108
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I IGFBP-2

<400> 108
Pro Leu Leu Pro Leu Leu Leu Leu Leu
 1               5

<210> 109
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I IGFBP-2

<400> 109
Leu Pro Leu Leu Pro Leu Leu Leu Leu
 1               5

<210> 110
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I IGFBP-2

<400> 110
Gly Pro Leu Glu His Leu Tyr Ser Leu
 1               5

<210> 111
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I IGFBP-2

<400> 111
Leu Glu His Leu Tyr Ser Leu His Ile
 1               5

<210> 112
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I IGFBP-2

<400> 112
Lys Leu Ile Gln Gly Ala Pro Thr Ile
 1               5

<210> 113
<211> 4664
<212> DNA
<213> Homo sapiens

<400> 113
gcttgctccc aatcacagga gaaggaggag gtggaggagg agggctgctt gaggaagtat      60
aagaatgaag ttgtgaagct gagattcccc tccattggga ccggagaaac caggggagcc     120
ccccgggcag ccgcgcgccc cttcccacgg ggccctttac tgcgccgcgc gcccggcccc     180
cacccctcgc agcaccccgc gccccgcgcc ctcccagccg ggtccagccg gagccatggg     240
gccggagccg cagtgagcac catggagctg gcggccttgt gccgctgggg gctcctcctc     300
gccctcttgc cccccggagc cgcgagcacc caagtgtgca ccggcacaga catgaagctg     360
cggctccctg ccagtcccga gacccacctg gacatgctcc gccacctcta ccagggctgc     420
caggtggtgc agggaaacct ggaactcacc tacctgccca ccaatgccag cctgtccttc     480
ctgcaggata tccaggaggt gcagggctac gtgctcatcg ctcacaacca agtgaggcag     540
gtcccactgc agaggctgcg gattgtgcga ggcacccagc tctttgagga caactatgcc     600
ctggccgtgc tagacaatgg agacccgctg aacaatacca cccctgtcac aggggcctcc     660
ccaggaggcc tgcgggagct gcagcttcga agcctcacag agatcttgaa aggaggggtc     720
ttgatccagc ggaaccccca gctctgctac caggacacga ttttgtggaa ggacatcttc     780
cacaagaaca accagctggc tctcacactg atagacacca accgctctcg ggcctgccac     840
ccctgttctc cgatgtgtaa gggctcccgc tgctggggag agagttctga ggattgtcag     900
agcctgacgc gcactgtctg tgccggtggc tgtgcccgct gcaaggggcc actgcccact     960
gactgctgcc atgagcagtg tgctgccggc tgcacgggcc ccaagcactc tgactgcctg    1020
gcctgcctcc acttcaacca cagtggcatc tgtgagctgc actgcccagc cctggtcacc    1080
tacaacacag acacgtttga gtccatgccc aatcccgagg gccggtatac attcggcgcc    1140
agctgtgtga ctgcctgtcc ctacaactac ctttctacgg acgtgggatc ctgcaccctc    1200
gtctgccccc tgcacaacca agaggtgaca gcagaggatg gaacacagcg gtgtgagaag    1260
tgcagcaagc cctgtgcccg agtgtgctat ggtctgggca tggagcactt gcgagaggtg    1320
agggcagtta ccagtgccaa tatccaggag tttgctggct gcaagaagat ctttgggagc    1380
ctggcatttc tgccggagag ctttgatggg gacccagcct ccaacactgc cccgctccag    1440
ccagagcagc tccaagtgtt tgagactctg gaagagatca caggttacct atacatctca    1500
gcatggccgg acagcctgcc tgacctcagc gtcttccaga acctgcaagt aatccgggga    1560
cgaattctgc acaatggcgc ctactcgctg accctgcaag ggctgggcat cagctggctg    1620
gggctgcgct cactgaggga actgggcagt ggactggccc tcatccacca taacacccac    1680
ctctgcttcg tgcacacggt gccctgggac cagctctttc ggaacccgca ccaagctctg    1740
ctccacactg ccaaccggcc agaggacgag tgtgtgggcg agggcctggc ctgccaccag    1800
ctgtgcgccc gagggcactg ctggggtcca gggcccaccc agtgtgtcaa ctgcagccag    1860
ttccttcggg gccaggagtg cgtggaggaa tgccgagtac tgcaggggct ccccagggag    1920
tatgtgaatg ccaggcactg tttgccgtgc caccctgagt gtcagcccca gaatggctca    1980
gtgacctgtt ttggaccgga ggctgaccag tgtgtggcct gtgcccacta taaggaccct    2040
cccttctgcg tggcccgctg ccccagcggt gtgaaacctg acctctccta catgcccatc    2100
tggaagtttc cagatgagga gggcgcatgc cagccttgcc ccatcaactg cacccactcc    2160
tgtgtggacc tggatgacaa gggctgcccc gccgagcaga gagccagccc tctgacgtcc    2220
atcatctctg cggtggttgg cattctgctg gtcgtggtct tgggggtggt ctttgggatc    2280
ctcatcaagc gacggcagca gaagatccgg aagtacacga tgcggagact gctgcaggaa    2340
acggagctgg tggagccgct gacacctagc ggagcgatgc ccaaccaggc gcagatgcgg    2400
atcctgaaag agacggagct gaggaaggtg aaggtgcttg gatctggcgc ttttggcaca    2460
gtctacaagg gcatctggat ccctgatggg gagaatgtga aaattccagt ggccatcaaa    2520
gtgttgaggg aaaacacatc ccccaaagcc aacaaagaaa tcttagacga agcatacgtg    2580
atggctggtg tgggctcccc atatgtctcc cgccttctgg gcatctgcct gacatccacg    2640
gtgcagctgg tgacacagct tatgccctat ggctgcctct tagaccatgt ccgggaaaac    2700
cgcggacgcc tgggctccca ggacctgctg aactggtgta tgcagattgc caaggggatg    2760
agctacctgg aggatgtgcg gctcgtacac agggacttgg ccgctcggaa cgtgctggtc    2820
aagagtccca accatgtcaa aattacagac ttcgggctgg ctcggctgct ggacattgac    2880
gagacagagt accatgcaga tgggggcaag gtgcccatca agtggatggc gctggagtcc    2940
attctccgcc ggcggttcac ccaccagagt gatgtgtgga gttatggtgt gactgtgtgg    3000
gagctgatga cttttggggc caaaccttac gatgggatcc cagcccggga gatccctgac    3060
ctgctggaaa agggggagcg gctgccccag ccccccatct gcaccattga tgtctacatg    3120
atcatggtca aatgttggat gattgactct gaatgtcggc caagattccg ggagttggtg    3180
tctgaattct cccgcatggc cagggacccc cagcgctttg tggtcatcca gaatgaggac    3240
ttgggcccag ccagtccctt ggacagcacc ttctaccgct cactgctgga ggacgatgac    3300
atgggggacc tggtggatgc tgaggagtat ctggtacccc agcagggctt cttctgtcca    3360
gaccctgccc cgggcgctgg gggcatggtc caccacaggc accgcagctc atctaccagg    3420
agtggcggtg gggacctgac actagggctg gagccctctg aagaggaggc ccccaggtct    3480
ccactggcac cctccgaagg ggctggctcc gatgtatttg atggtgacct gggaatgggg    3540
gcagccaagg ggctgcaaag cctccccaca catgacccca gccctctaca gcggtacagt    3600
gaggacccca cagtacccct gccctctgag actgatggct acgttgcccc cctgacctgc    3660
agcccccagc ctgaatatgt gaaccagcca gatgttcggc cccagccccc ttcgccccga    3720
gagggccctc tgcctgctgc ccgacctgct ggtgccactc tggaaaggcc caagactctc    3780
tccccaggga agaatggggt cgtcaaagac gtttttgcct ttgggggtgc cgtggagaac    3840
cccgagtact tgacacccca gggaggagct gcccctcagc cccaccctcc tcctgccttc    3900
agcccagcct tcgacaacct ctattactgg gaccaggacc caccagagcg gggggctcca    3960
cccagcacct tcaaagggac acctacggca gagaacccag agtacctggg tctggacgtg    4020
ccagtgtgaa ccagaaggcc aagtccgcag aagccctgat gtgtcctcag ggagcaggga    4080
aggcctgact tctgctggca tcaagaggtg ggagggccct ccgaccactt ccaggggaac    4140
ctgccatgcc aggaacctgt cctaaggaac cttccttcct gcttgagttc ccagatggct    4200
ggaaggggtc cagcctcgtt ggaagaggaa cagcactggg gagtctttgt ggattctgag    4260
gccctgccca atgagactct agggtccagt ggatgccaca gcccagcttg gccctttcct    4320
tccagatcct gggtactgaa agccttaggg aagctggcct gagaggggaa gcggccctaa    4380
gggagtgtct aagaacaaaa gcgacccatt cagagactgt ccctgaaacc tagtactgcc    4440
ccccatgagg aaggaacagc aatggtgtca gtatccaggc tttgtacaga gtgcttttct    4500
gtttagtttt tacttttttt gttttgtttt tttaaagatg aaataaagac ccagggggag    4560
aatgggtgtt gtatggggag gcaagtgtgg ggggtccttc tccacaccca ctttgtccat    4620
ttgcaaatat attttggaaa acagctaaaa aaaaaaaaaa aaaa                     4664

<210> 114
<211> 1255
<212> PRT
<213> Homo sapiens

<400> 114
Met Glu Leu Ala Ala Leu Cys Arg Trp Gly Leu Leu Leu Ala Leu Leu
 1               5                  10                  15
Pro Pro Gly Ala Ala Ser Thr Gln Val Cys Thr Gly Thr Asp Met Lys
            20                  25                  30
Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His
        35                  40                  45
Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
    50                  55                  60
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val
65                  70                  75                  80
Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu
                85                  90                  95
Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr
            100                 105                 110
Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro
        115                 120                 125
Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser
    130                 135                 140
Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln
145                 150                 155                 160
Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn
                165                 170                 175
Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys
            180                 185                 190
His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser
        195                 200                 205
Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys
    210                 215                 220
Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys
225                 230                 235                 240
Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu
                245                 250                 255
His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val
            260                 265                 270
Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg
        275                 280                 285
Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu
    290                 295                 300
Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln
305                 310                 315                 320
Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys
                325                 330                 335
Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu
            340                 345                 350
Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys
        355                 360                 365
Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp
    370                 375                 380
Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe
385                 390                 395                 400
Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro
                405                 410                 415
Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg
            420                 425                 430
Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu
        435                 440                 445
Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly
    450                 455                 460
Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His Thr Val
465                 470                 475                 480
Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr
                485                 490                 495
Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His
            500                 505                 510
Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys
        515                 520                 525
Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys
    530                 535                 540
Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys
545                 550                 555                 560
Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys
                565                 570                 575
Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp
            580                 585                 590
Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu
        595                 600                 605
Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln
    610                 615                 620
Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys
625                 630                 635                 640
Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser
                645                 650                 655
Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly
            660                 665                 670
Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg
        675                 680                 685
Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly
    690                 695                 700
Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu
705                 710                 715                 720
Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys
                725                 730                 735
Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile
            740                 745                 750
Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu
        755                 760                 765
Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg
    770                 775                 780
Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu
785                 790                 795                 800
Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg
                805                 810                 815
Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly
            820                 825                 830
Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala
        835                 840                 845
Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe
    850                 855                 860
Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp
865                 870                 875                 880
Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg
                885                 890                 895
Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val
            900                 905                 910
Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala
        915                 920                 925
Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro
    930                 935                 940
Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met
945                 950                 955                 960
Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe
                965                 970                 975
Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu
            980                 985                 990
Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu
        995                 1000                1005
Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu
    1010                1015                1020
Val Pro Gln Gln Gly Phe Phe Cys Pro Asp Pro Ala Pro Gly Ala Gly
1025                1030                1035                1040
Gly Met Val His His Arg His Arg Ser Ser Ser Thr Arg Ser Gly Gly
                1045                1050                1055
Gly Asp Leu Thr Leu Gly Leu Glu Pro Ser Glu Glu Glu Ala Pro Arg
            1060                1065                1070
Ser Pro Leu Ala Pro Ser Glu Gly Ala Gly Ser Asp Val Phe Asp Gly
        1075                1080                1085
Asp Leu Gly Met Gly Ala Ala Lys Gly Leu Gln Ser Leu Pro Thr His
    1090                1095                1100
Asp Pro Ser Pro Leu Gln Arg Tyr Ser Glu Asp Pro Thr Val Pro Leu
1105                1110                1115                1120
Pro Ser Glu Thr Asp Gly Tyr Val Ala Pro Leu Thr Cys Ser Pro Gln
                1125                1130                1135
Pro Glu Tyr Val Asn Gln Pro Asp Val Arg Pro Gln Pro Pro Ser Pro
            1140                1145                1150
Arg Glu Gly Pro Leu Pro Ala Ala Arg Pro Ala Gly Ala Thr Leu Glu
        1155                1160                1165
Arg Pro Lys Thr Leu Ser Pro Gly Lys Asn Gly Val Val Lys Asp Val
    1170                1175                1180
Phe Ala Phe Gly Gly Ala Val Glu Asn Pro Glu Tyr Leu Thr Pro Gln
1185                1190                1195                1200
Gly Gly Ala Ala Pro Gln Pro His Pro Pro Pro Ala Phe Ser Pro Ala
                1205                1210                1215
Phe Asp Asn Leu Tyr Tyr Trp Asp Gln Asp Pro Pro Glu Arg Gly Ala
            1220                1225                1230
Pro Pro Ser Thr Phe Lys Gly Thr Pro Thr Ala Glu Asn Pro Glu Tyr
        1235                1240                1245
Leu Gly Leu Asp Val Pro Val
    1250                1255

<210> 115
<211> 181
<212> PRT
<213> Artificial Sequence

<220> 
<223> HER2 - Class II embedded class I (4 plus 1)

<400> 115
Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser
 1               5                  10                  15
Leu Ser Phe Leu Gln Asp Ile Gly Gly Gly Gly Ser Gly Gly Gly Gly
            20                  25                  30
Ser Gly Gly Gly Gly Ser Val Leu Ile Ala His Asn Gln Val Arg Gln
        35                  40                  45
Val Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Gly Gly Gly
    50                  55                  60
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ile Phe Gly
65                  70                  75                  80
Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Gly Gly
                85                  90                  95
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Leu Pro
            100                 105                 110
Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu
        115                 120                 125
His Asn Gly Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
    130                 135                 140
Gly Gly Ser Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser
145                 150                 155                 160
Ile Leu Arg Arg Arg Phe Thr His Gln Ser Tyr Thr Asp Ile Glu Met
                165                 170                 175
Asn Arg Leu Gly Lys
            180

<210> 116
<211> 149
<212> PRT
<213> Artificial Sequence

<220> 
<223> HER2 - Class II embedded class I (4 plus 1) no
      flanking AA

<400> 116
Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Gly
 1               5                  10                  15
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Asn
            20                  25                  30
Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val Gly Gly Gly
        35                  40                  45
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ile Phe Gly
    50                  55                  60
Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Gly Gly
65                  70                  75                  80
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Ser Val
                85                  90                  95
Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu Gly Gly Gly Gly
            100                 105                 110
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Pro Ile Lys Trp Met
        115                 120                 125
Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe Tyr Thr Asp Ile Glu Met
    130                 135                 140
Asn Arg Leu Gly Lys
145

<210> 117
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> HLA Class II HER2

<400> 117
Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe
 1               5                  10                  15

<210> 118
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> HLA Class II HER2

<400> 118
His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val
 1               5                  10                  15

<210> 119
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> HLA Class II HER2

<400> 119
Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu
 1               5                  10                  15

<210> 120
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> HLA Class II HER2

<400> 120
Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe
 1               5                  10                  15

<210> 121
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide HER2

<400> 121
Thr Tyr Leu Pro Thr Asn Ala Ser Leu
 1               5

<210> 122
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide HER2

<400> 122
Leu Pro Thr Asn Ala Ser Leu Ser Phe
 1               5

<210> 123
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide HER2

<400> 123
Thr Tyr Leu Pro Thr Asn Ala Ser Leu
 1               5

<210> 124
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide HER2

<400> 124
Gln Val Arg Gln Val Pro Leu Gln Arg
 1               5

<210> 125
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide HER2

<400> 125
Val Pro Leu Gln Arg Leu Arg Ile Val
 1               5

<210> 126
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide HER2

<400> 126
His Asn Gln Val Arg Gln Val Pro Leu
 1               5

<210> 127
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide HER2

<400> 127
Val Pro Leu Gln Arg Leu Arg Ile Val
 1               5

<210> 128
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide HER2

<400> 128
Arg Gln Val Pro Leu Gln Arg Leu Arg
 1               5

<210> 129
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide HER2

<400> 129
His Asn Gln Val Arg Gln Val Pro Leu
 1               5

<210> 130
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide HER2

<400> 130
Ser Val Phe Gln Asn Leu Gln Val Ile
 1               5

<210> 131
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide HER2

<400> 131
Leu Gln Val Ile Arg Gly Arg Ile Leu
 1               5

<210> 132
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide HER2

<400> 132
Leu Gln Val Ile Arg Gly Arg Ile Leu
 1               5

<210> 133
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide HER2

<400> 133
Met Ala Leu Glu Ser Ile Leu Arg Arg
 1               5

<210> 134
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide HER2

<400> 134
Lys Trp Met Ala Leu Glu Ser Ile Leu
 1               5

<210> 135
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Embedded HLA Class I peptide HER2

<400> 135
Leu Glu Ser Ile Leu Arg Arg Arg Phe
 1               5

<210> 136
<211> 555
<212> DNA
<213> Artificial Sequence

<220> 
<223> HER2 reverse translated

<400> 136
tctagagtgg tgcagggcaa cctggagctg acctacctgc ccaccaacgc cagcctgagc      60
ttcctgcagg acatcggcgg cggcggcagc ggcggcggcg gcagcggcgg cggcggcagc     120
gtgctgatcg cccacaacca ggtgagacag gtgcccctgc agagactgag aatcgtgaga     180
ggcacccagg gcggcggcgg cagcggcggc ggcggcagcg gcggcggcgg cagcaagatc     240
ttcggcagcc tggccttcct gcccgagagc ttcgacggcg accccgccgg cggcggcggc     300
agcggcggcg gcggcagcgg cggcggcggc agcagcctgc ccgacctgag cgtgttccag     360
aacctgcagg tgatcagagg cagaatcctg cacaacggcg ccggcggcgg cggcagcggc     420
ggcggcggca gcggcggcgg cggcagcggc ggcaaggtgc ccatcaagtg gatggccctg     480
gagagcatcc tgagaagaag attcacccac cagagctaca ccgacatcga gatgaacaga     540
ctgggcaagt ctaga                                                      555

<210> 137
<211> 976
<212> DNA
<213> Artificial Sequence

<220> 
<223> MTI-HER2 PAA

<400> 137
gggtggagat gtagaagatg tgacgccgcg gcccggcggg tgccagatta gcggacgcgg      60
tgcccgcggt tgcaacggga tcccgggcgc tgcagcttgg gaggcggctc tccccaggcg     120
gcgtccgcgg agacacccat ccgtgaaccc caggtcccgg gccgccggct cgccgcgcac     180
caggggccgg cggacagaag agcggccgag cggctcgagg ctgggggacc gcgggcgcgg     240
ccgcgcgctg ccgggcggga ggctgggggg ccggggccgg ggccgtgccc cggagcgggt     300
cggaggccgg ggccggggcc gggggacggc ggctccccgc gcggctccag cggctcgggg     360
atcccggccg ggccccgcag ggacctctag agtggtgcag ggcaacctgg agctgaccta     420
cctgcccacc aacgccagcc tgagcttcct gcaggacatc ggcggcggcg gcagcggcgg     480
cggcggcagc ggcggcggcg gcagcgtgct gatcgcccac aaccaggtga gacaggtgcc     540
cctgcagaga ctgagaatcg tgagaggcac ccagggcggc ggcggcagcg gcggcggcgg     600
cagcggcggc ggcggcagca agatcttcgg cagcctggcc ttcctgcccg agagcttcga     660
cggcgacccc gccggcggcg gcggcagcgg cggcggcggc agcggcggcg gcggcagcag     720
cctgcccgac ctgagcgtgt tccagaacct gcaggtgatc agaggcagaa tcctgcacaa     780
cggcgccggc ggcggcggca gcggcggcgg cggcagcggc ggcggcggca gcggcggcaa     840
ggtgcccatc aagtggatgg ccctggagag catcctgaga agaagattca cccaccagag     900
ctacaccgac atcgagatga acagactggg caagtctaga tacaccgaca tcgagatgaa     960
cagactgggc aagtaa                                                     976

<210> 138
<211> 251
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-HER2 PAA
      
      

<400> 138
Met Gly Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly
 1               5                  10                  15
Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg
            20                  25                  30
Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser
        35                  40                  45
Arg Pro Gly Pro Ala Gly Thr Ser Arg Val Val Gln Gly Asn Leu Glu
    50                  55                  60
Leu Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile
65                  70                  75                  80
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val
                85                  90                  95
Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg
            100                 105                 110
Ile Val Arg Gly Thr Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        115                 120                 125
Gly Gly Gly Gly Ser Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu
    130                 135                 140
Ser Phe Asp Gly Asp Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly
145                 150                 155                 160
Ser Gly Gly Gly Gly Ser Ser Leu Pro Asp Leu Ser Val Phe Gln Asn
                165                 170                 175
Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn Gly Ala Gly Gly Gly
            180                 185                 190
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Lys Val
        195                 200                 205
Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe Thr
    210                 215                 220
His Gln Ser Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys Ser Arg
225                 230                 235                 240
Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys
                245                 250

<210> 139
<211> 1582
<212> DNA
<213> Artificial Sequence

<220> 
<223> MTI-HER2 PAA - secreted
      
      

<400> 139
gggtggagat gtagaagatg tgacgccgcg gcccggcggg tgccagatta gcggacgcgg      60
tgcccgcggt tgcaacggga tcccgggcgc tgcagcttgg gaggcggctc tccccaggcg     120
gcgtccgcgg agacacccat ccgtgaaccc caggtcccgg gccgccggct cgccgcgcac     180
caggggccgg cggacagaag agcggccgag cggctcgagg ctgggggacc gcgggcgcgg     240
ccgcgcgctg ccgggcggga ggctgggggg ccggggccgg ggccgtgccc cggagcgggt     300
cggaggccgg ggccggggcc gggggacggc ggctccccgc gcggctccag cggctcgggg     360
atcccggccg ggccccgcag ggaccaagtg cctgctgtac ctggccttcc tgttcatcgg     420
cgtgaactgc aagttctacc ccagctacca cagcaccccc cagagaccct tcaccatact     480
ttttccacac aaccaaaaag gaaactggaa aaatgttcct tctaattacc attattgccc     540
gtcaagctca gatttaaatt ggcataatga cttaataggc acagccatac aagtcaaaat     600
gcccaagagt cacaaggcta ttcaagcaga cggttggatg tgtcatgctt ccaaatgggt     660
cactacttgt gatttccgct ggtatggacc gaagtatata acacagtcca tccgatcctt     720
cactccatct gtagaacaat gcaaggaaag cattgaacaa acgaaacaag gaacttggct     780
gaatccaggc ttccctcctc aaagttgtgg atatgcaact gtgacggatg ccgaagcagt     840
gattgtccag gtgactcctc accatgtgct ggttgatgaa tacacaggag aatgggttga     900
ttcacagttc atcaacggaa aatgcagcaa ttacatatgc cccactgtcc ataactctac     960
aacctggcat tctgactata aggtcaaagg gtctagagtg gtgcagggca acctggagct    1020
gacctacctg cccaccaacg ccagcctgag cttcctgcag gacatcggcg gcggcggcag    1080
cggcggcggc ggcagcggcg gcggcggcag cgtgctgatc gcccacaacc aggtgagaca    1140
ggtgcccctg cagagactga gaatcgtgag aggcacccag ggcggcggcg gcagcggcgg    1200
cggcggcagc ggcggcggcg gcagcaagat cttcggcagc ctggccttcc tgcccgagag    1260
cttcgacggc gaccccgccg gcggcggcgg cagcggcggc ggcggcagcg gcggcggcgg    1320
cagcagcctg cccgacctga gcgtgttcca gaacctgcag gtgatcagag gcagaatcct    1380
gcacaacggc gccggcggcg gcggcagcgg cggcggcggc agcggcggcg gcggcagcgg    1440
cggcaaggtg cccatcaagt ggatggccct ggagagcatc ctgagaagaa gattcaccca    1500
ccagagctac accgacatcg agatgaacag actgggcaag tctagataca ccgacatcga    1560
gatgaacaga ctgggcaagt aa                                             1582

<210> 140
<211> 453
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-HER2 PAA - secreted
      
      

<400> 140
Met Gly Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly
 1               5                  10                  15
Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg
            20                  25                  30
Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser
        35                  40                  45
Arg Pro Gly Pro Ala Gly Thr Lys Cys Leu Leu Tyr Leu Ala Phe Leu
    50                  55                  60
Phe Ile Gly Val Asn Cys Lys Phe Tyr Pro Ser Tyr His Ser Thr Pro
65                  70                  75                  80
Gln Arg Pro Phe Thr Ile Leu Phe Pro His Asn Gln Lys Gly Asn Trp
                85                  90                  95
Lys Asn Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu
            100                 105                 110
Asn Trp His Asn Asp Leu Ile Gly Thr Ala Ile Gln Val Lys Met Pro
        115                 120                 125
Lys Ser His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser
    130                 135                 140
Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile
145                 150                 155                 160
Thr Gln Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu
                165                 170                 175
Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro
            180                 185                 190
Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile
        195                 200                 205
Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu
    210                 215                 220
Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys
225                 230                 235                 240
Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys
                245                 250                 255
Gly Ser Arg Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr
            260                 265                 270
Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gly Gly Gly Gly Ser Gly
        275                 280                 285
Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Leu Ile Ala His Asn Gln
    290                 295                 300
Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln
305                 310                 315                 320
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys
                325                 330                 335
Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro
            340                 345                 350
Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
        355                 360                 365
Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly
    370                 375                 380
Arg Ile Leu His Asn Gly Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly
385                 390                 395                 400
Ser Gly Gly Gly Gly Ser Gly Gly Lys Val Pro Ile Lys Trp Met Ala
                405                 410                 415
Leu Glu Ser Ile Leu Arg Arg Arg Phe Thr His Gln Ser Tyr Thr Asp
            420                 425                 430
Ile Glu Met Asn Arg Leu Gly Lys Ser Arg Tyr Thr Asp Ile Glu Met
        435                 440                 445
Asn Arg Leu Gly Lys
    450

<210> 141
<211> 1516
<212> DNA
<213> Artificial Sequence

<220> 
<223> MTI-HER2 PAA - secreted - VSVG variant
      
      

<400> 141
gggtggagat gtagaagatg tgacgccgcg gcccggcggg tgccagatta gcggacgcgg      60
tgcccgcggt tgcaacggga tcccgggcgc tgcagcttgg gaggcggctc tccccaggcg     120
gcgtccgcgg agacacccat ccgtgaaccc caggtcccgg gccgccggct cgccgcgcac     180
caggggccgg cggacagaag agcggccgag cggctcgagg ctgggggacc gcgggcgcgg     240
ccgcgcgctg ccgggcggga ggctgggggg ccggggccgg ggccgtgccc cggagcgggt     300
cggaggccgg ggccggggcc gggggacggc ggctccccgc gcggctccag cggctcgggg     360
atcccggccg ggccccgcag ggaccaagtg cctgctgtac ctggccttcc tgttcatcgg     420
cgtgaactgc aagttctacc ccagctacca cagcaccccc cagagaccct ctagagtggt     480
gcagggcaac ctggagctga cctacctgcc caccaacgcc agcctgagct tcctgcagga     540
catcggcggc ggcggcagcg gcggcggcgg cagcggcggc ggcggcagcg tgctgatcgc     600
ccacaaccag gtgagacagg tgcccctgca gagactgaga atcgtgagag gcacccaggg     660
cggcggcggc agcggcggcg gcggcagcgg cggcggcggc agcaagatct tcggcagcct     720
ggccttcctg cccgagagct tcgacggcga ccccgccggc ggcggcggca gcggcggcgg     780
cggcagcggc ggcggcggca gcagcctgcc cgacctgagc gtgttccaga acctgcaggt     840
gatcagaggc agaatcctgc acaacggcgc cggcggcggc ggcagcggcg gcggcggcag     900
cggcggcggc ggcagcggcg gcaaggtgcc catcaagtgg atggccctgg agagcatcct     960
gagaagaaga ttcacccacc agagctacac cgacatcgag atgaacagac tgggcaagtc    1020
tagacttcca atctctccag tggatctcag ctatcttgct cctaaaaacc caggaaccgg    1080
tcctgctttc accataatca atggtaccct aaaatacttt gagaccagat acatcagagt    1140
cgatattgct gctccaatcc tctcaagaat ggtcggaatg atcagtggaa ctaccacaga    1200
aagggaactg tgggatgact gggcaccata tgaagacgtg gaaattggac ccaatggagt    1260
tctgaggacc agttcaggat ataagtttcc tttatacatg attggacatg gtatgttgga    1320
ctccgatctt catcttagct caaaggctca ggtgttcgaa catcctcaca ttcaagacgc    1380
tgcttcgcaa cttcctgatg atgagagttt attttttggt gatactgggc tatccaaaaa    1440
tccaatcgag cttgtagaag gttggttcag tagttggaaa tacaccgaca tcgagatgaa    1500
cagactgggc aagtaa                                                    1516

<210> 142
<211> 431
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-HER2 PAA - secreted - VSVG variant
      
      

<400> 142
Met Gly Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly
 1               5                  10                  15
Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg
            20                  25                  30
Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser
        35                  40                  45
Arg Pro Gly Pro Ala Gly Thr Lys Cys Leu Leu Tyr Leu Ala Phe Leu
    50                  55                  60
Phe Ile Gly Val Asn Cys Lys Phe Tyr Pro Ser Tyr His Ser Thr Pro
65                  70                  75                  80
Gln Arg Pro Ser Arg Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu
                85                  90                  95
Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gly Gly Gly Gly
            100                 105                 110
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Leu Ile Ala His
        115                 120                 125
Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val Arg Gly
    130                 135                 140
Thr Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
145                 150                 155                 160
Ser Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly
                165                 170                 175
Asp Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
            180                 185                 190
Gly Ser Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile
        195                 200                 205
Arg Gly Arg Ile Leu His Asn Gly Ala Gly Gly Gly Gly Ser Gly Gly
    210                 215                 220
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Lys Val Pro Ile Lys Trp
225                 230                 235                 240
Met Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe Thr His Gln Ser Tyr
                245                 250                 255
Thr Asp Ile Glu Met Asn Arg Leu Gly Lys Ser Arg Leu Pro Ile Ser
            260                 265                 270
Pro Val Asp Leu Ser Tyr Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro
        275                 280                 285
Ala Phe Thr Ile Ile Asn Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr
    290                 295                 300
Ile Arg Val Asp Ile Ala Ala Pro Ile Leu Ser Arg Met Val Gly Met
305                 310                 315                 320
Ile Ser Gly Thr Thr Thr Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro
                325                 330                 335
Tyr Glu Asp Val Glu Ile Gly Pro Asn Gly Val Leu Arg Thr Ser Ser
            340                 345                 350
Gly Tyr Lys Phe Pro Leu Tyr Met Ile Gly His Gly Met Leu Asp Ser
        355                 360                 365
Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile
    370                 375                 380
Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly
385                 390                 395                 400
Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe
                405                 410                 415
Ser Ser Trp Lys Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys
            420                 425                 430

<210> 143
<211> 422
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-HER2 PAA - secreted - VSVG variant
      
      

<400> 143
Leu Pro Gly Gly Arg Leu Gly Gly Arg Gly Arg Gly Arg Ala Pro Glu
 1               5                  10                  15
Arg Val Gly Gly Arg Gly Arg Gly Arg Gly Thr Ala Ala Pro Arg Ala
            20                  25                  30
Ala Pro Ala Ala Arg Gly Ser Arg Pro Gly Pro Ala Gly Thr Lys Cys
        35                  40                  45
Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys Lys Phe Tyr
    50                  55                  60
Pro Ser Tyr His Ser Thr Pro Gln Arg Pro Ser Arg Val Val Gln Gly
65                  70                  75                  80
Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu
                85                  90                  95
Gln Asp Ile Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
            100                 105                 110
Gly Ser Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu Gln
        115                 120                 125
Arg Leu Arg Ile Val Arg Gly Thr Gln Gly Gly Gly Gly Ser Gly Gly
    130                 135                 140
Gly Gly Ser Gly Gly Gly Gly Ser Lys Ile Phe Gly Ser Leu Ala Phe
145                 150                 155                 160
Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Gly Gly Gly Gly Ser Gly
                165                 170                 175
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Leu Pro Asp Leu Ser Val
            180                 185                 190
Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn Gly Ala
        195                 200                 205
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
    210                 215                 220
Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg
225                 230                 235                 240
Arg Phe Thr His Gln Ser Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly
                245                 250                 255
Lys Ser Arg Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr Leu Ala Pro
            260                 265                 270
Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn Gly Thr Leu
        275                 280                 285
Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala Ala Pro Ile
    290                 295                 300
Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr Glu Arg Glu
305                 310                 315                 320
Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile Gly Pro Asn
                325                 330                 335
Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu Tyr Met Ile
            340                 345                 350
Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln
        355                 360                 365
Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp
    370                 375                 380
Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile
385                 390                 395                 400
Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Tyr Thr Asp Ile Glu
                405                 410                 415
Met Asn Arg Leu Gly Lys
            420

<210> 144
<211> 417
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-HER2 PAA - secreted - VSVG variant
      
      

<400> 144
Leu Gly Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg
 1               5                  10                  15
Gly Arg Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg
            20                  25                  30
Gly Ser Arg Pro Gly Pro Ala Gly Thr Lys Cys Leu Leu Tyr Leu Ala
        35                  40                  45
Phe Leu Phe Ile Gly Val Asn Cys Lys Phe Tyr Pro Ser Tyr His Ser
    50                  55                  60
Thr Pro Gln Arg Pro Ser Arg Val Val Gln Gly Asn Leu Glu Leu Thr
65                  70                  75                  80
Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gly Gly
                85                  90                  95
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Leu Ile
            100                 105                 110
Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val
        115                 120                 125
Arg Gly Thr Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
    130                 135                 140
Gly Gly Ser Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe
145                 150                 155                 160
Asp Gly Asp Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
                165                 170                 175
Gly Gly Gly Ser Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln
            180                 185                 190
Val Ile Arg Gly Arg Ile Leu His Asn Gly Ala Gly Gly Gly Gly Ser
        195                 200                 205
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Lys Val Pro Ile
    210                 215                 220
Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe Thr His Gln
225                 230                 235                 240
Ser Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys Ser Arg Leu Pro
                245                 250                 255
Ile Ser Pro Val Asp Leu Ser Tyr Leu Ala Pro Lys Asn Pro Gly Thr
            260                 265                 270
Gly Pro Ala Phe Thr Ile Ile Asn Gly Thr Leu Lys Tyr Phe Glu Thr
        275                 280                 285
Arg Tyr Ile Arg Val Asp Ile Ala Ala Pro Ile Leu Ser Arg Met Val
    290                 295                 300
Gly Met Ile Ser Gly Thr Thr Thr Glu Arg Glu Leu Trp Asp Asp Trp
305                 310                 315                 320
Ala Pro Tyr Glu Asp Val Glu Ile Gly Pro Asn Gly Val Leu Arg Thr
                325                 330                 335
Ser Ser Gly Tyr Lys Phe Pro Leu Tyr Met Ile Gly His Gly Met Leu
            340                 345                 350
Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro
        355                 360                 365
His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe
    370                 375                 380
Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly
385                 390                 395                 400
Trp Phe Ser Ser Trp Lys Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly
                405                 410                 415
Lys


<210> 145
<211> 2155
<212> DNA
<213> Artificial Sequence

<220> 
<223> MTI-HER2 PAA - membrane anchored
      
      

<400> 145
gggtggagat gtagaagatg tgacgccgcg gcccggcggg tgccagatta gcggacgcgg      60
tgcccgcggt tgcaacggga tcccgggcgc tgcagcttgg gaggcggctc tccccaggcg     120
gcgtccgcgg agacacccat ccgtgaaccc caggtcccgg gccgccggct cgccgcgcac     180
caggggccgg cggacagaag agcggccgag cggctcgagg ctgggggacc gcgggcgcgg     240
ccgcgcgctg ccgggcggga ggctgggggg ccggggccgg ggccgtgccc cggagcgggt     300
cggaggccgg ggccggggcc gggggacggc ggctccccgc gcggctccag cggctcgggg     360
atcccggccg ggccccgcag ggaccaagtg ccttttgtac ttagcctttt tattcattgg     420
ggtgaattgc aagttttacc cttcttatca ctctacccca cagcggccta agttcaccat     480
actttttcca cacaaccaaa aaggaaactg gaaaaatgtt ccttctaatt accattattg     540
cccgtcaagc tcagatttaa attggcataa tgacttaata ggcacagcca tacaagtcaa     600
aatgcccaag agtcacaagg ctattcaagc agacggttgg atgtgtcatg cttccaaatg     660
ggtcactact tgtgatttcc gctggtatgg accgaagtat ataacacagt ccatccgatc     720
cttcactcca tctgtagaac aatgcaagga aagcattgaa caaacgaaac aaggaacttg     780
gctgaatcca ggcttccctc ctcaaagttg tggatatgca actgtgacgg atgccgaagc     840
agtgattgtc caggtgactc ctcaccatgt gctggttgat gaatacacag gagaatgggt     900
tgattcacag ttcatcaacg gaaaatgcag caattacata tgccccactg tccataactc     960
tacaacctgg cattctgact ataaggtcaa agggtctaga gtggtgcagg gcaacctgga    1020
gctgacctac ctgcccacca acgccagcct gagcttcctg caggacatcg gcggcggcgg    1080
cagcggcggc ggcggcagcg gcggcggcgg cagcgtgctg atcgcccaca accaggtgag    1140
acaggtgccc ctgcagagac tgagaatcgt gagaggcacc cagggcggcg gcggcagcgg    1200
cggcggcggc agcggcggcg gcggcagcaa gatcttcggc agcctggcct tcctgcccga    1260
gagcttcgac ggcgaccccg ccggcggcgg cggcagcggc ggcggcggca gcggcggcgg    1320
cggcagcagc ctgcccgacc tgagcgtgtt ccagaacctg caggtgatca gaggcagaat    1380
cctgcacaac ggcgccggcg gcggcggcag cggcggcggc ggcagcggcg gcggcggcag    1440
cggcggcaag gtgcccatca agtggatggc cctggagagc atcctgagaa gaagattcac    1500
ccaccagagc tacaccgaca tcgagatgaa cagactgggc aagtctagac ttcccatctc    1560
tccagtggat ctcagctatc ttgctcctaa aaacccagga accggtcctg tctttaccat    1620
aatcaatggt accctaaaat actttgagac cagatacatc agagtcgata ttgctgctcc    1680
aatcctctca agaatggtcg gaatgatcag tggaactacc acagaaaggg aactgtggga    1740
tgactgggct ccatatgaag acgtggaaat tggacccaat ggagttctga ggaccagttt    1800
aggatataag tttcctttat atatgattgg acatggtatg ttggactccg atcttcatct    1860
tagctcaaag gctcaggtgt ttgaacatcc tcacattcaa gacgctgctt cgcagcttcc    1920
tgatgatgag actttatttt ttggtgatac tgggctatcc aaaaatccaa tcgagtttgt    1980
agaaggttgg ttcagtagtt ggaagagctc tattgcctct tttttcttta tcatagggtt    2040
aatcattgga ctattcttgg ttctccgagt tggtatttat ctttgcatta aattaaagca    2100
caccaagaaa agacagattt atacagacat agagatgaac cgacttggaa agtaa         2155

<210> 146
<211> 644
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-HER2 PAA - membrane anchored
      
      

<400> 146
Met Gly Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly
 1               5                  10                  15
Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg
            20                  25                  30
Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser
        35                  40                  45
Arg Pro Gly Pro Ala Gly Thr Lys Cys Leu Leu Tyr Leu Ala Phe Leu
    50                  55                  60
Phe Ile Gly Val Asn Cys Lys Phe Tyr Pro Ser Tyr His Ser Thr Pro
65                  70                  75                  80
Gln Arg Pro Lys Phe Thr Ile Leu Phe Pro His Asn Gln Lys Gly Asn
                85                  90                  95
Trp Lys Asn Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp
            100                 105                 110
Leu Asn Trp His Asn Asp Leu Ile Gly Thr Ala Ile Gln Val Lys Met
        115                 120                 125
Pro Lys Ser His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala
    130                 135                 140
Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr
145                 150                 155                 160
Ile Thr Gln Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys
                165                 170                 175
Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe
            180                 185                 190
Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val
        195                 200                 205
Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly
    210                 215                 220
Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile
225                 230                 235                 240
Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val
                245                 250                 255
Lys Gly Ser Arg Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro
            260                 265                 270
Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gly Gly Gly Gly Ser
        275                 280                 285
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Leu Ile Ala His Asn
    290                 295                 300
Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr
305                 310                 315                 320
Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
                325                 330                 335
Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp
            340                 345                 350
Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
        355                 360                 365
Ser Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg
    370                 375                 380
Gly Arg Ile Leu His Asn Gly Ala Gly Gly Gly Gly Ser Gly Gly Gly
385                 390                 395                 400
Gly Ser Gly Gly Gly Gly Ser Gly Gly Lys Val Pro Ile Lys Trp Met
                405                 410                 415
Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe Thr His Gln Ser Tyr Thr
            420                 425                 430
Asp Ile Glu Met Asn Arg Leu Gly Lys Ser Arg Leu Pro Ile Ser Pro
        435                 440                 445
Val Asp Leu Ser Tyr Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Val
    450                 455                 460
Phe Thr Ile Ile Asn Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile
465                 470                 475                 480
Arg Val Asp Ile Ala Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile
                485                 490                 495
Ser Gly Thr Thr Thr Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr
            500                 505                 510
Glu Asp Val Glu Ile Gly Pro Asn Gly Val Leu Arg Thr Ser Leu Gly
        515                 520                 525
Tyr Lys Phe Pro Leu Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp
    530                 535                 540
Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln
545                 550                 555                 560
Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly Asp
                565                 570                 575
Thr Gly Leu Ser Lys Asn Pro Ile Glu Phe Val Glu Gly Trp Phe Ser
            580                 585                 590
Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile
        595                 600                 605
Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile Tyr Leu Cys Ile Lys
    610                 615                 620
Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn
625                 630                 635                 640
Arg Leu Gly Lys


<210> 147
<211> 635
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-HER2 PAA - membrane anchored
      
      

<400> 147
Leu Pro Gly Gly Arg Leu Gly Gly Arg Gly Arg Gly Arg Ala Pro Glu
 1               5                  10                  15
Arg Val Gly Gly Arg Gly Arg Gly Arg Gly Thr Ala Ala Pro Arg Ala
            20                  25                  30
Ala Pro Ala Ala Arg Gly Ser Arg Pro Gly Pro Ala Gly Thr Lys Cys
        35                  40                  45
Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys Lys Phe Tyr
    50                  55                  60
Pro Ser Tyr His Ser Thr Pro Gln Arg Pro Lys Phe Thr Ile Leu Phe
65                  70                  75                  80
Pro His Asn Gln Lys Gly Asn Trp Lys Asn Val Pro Ser Asn Tyr His
                85                  90                  95
Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp His Asn Asp Leu Ile Gly
            100                 105                 110
Thr Ala Ile Gln Val Lys Met Pro Lys Ser His Lys Ala Ile Gln Ala
        115                 120                 125
Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe
    130                 135                 140
Arg Trp Tyr Gly Pro Lys Tyr Ile Thr Gln Ser Ile Arg Ser Phe Thr
145                 150                 155                 160
Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly
                165                 170                 175
Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr
            180                 185                 190
Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His His Val
        195                 200                 205
Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn
    210                 215                 220
Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr
225                 230                 235                 240
Trp His Ser Asp Tyr Lys Val Lys Gly Ser Arg Val Val Gln Gly Asn
                245                 250                 255
Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln
            260                 265                 270
Asp Ile Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
        275                 280                 285
Ser Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg
    290                 295                 300
Leu Arg Ile Val Arg Gly Thr Gln Gly Gly Gly Gly Ser Gly Gly Gly
305                 310                 315                 320
Gly Ser Gly Gly Gly Gly Ser Lys Ile Phe Gly Ser Leu Ala Phe Leu
                325                 330                 335
Pro Glu Ser Phe Asp Gly Asp Pro Ala Gly Gly Gly Gly Ser Gly Gly
            340                 345                 350
Gly Gly Ser Gly Gly Gly Gly Ser Ser Leu Pro Asp Leu Ser Val Phe
        355                 360                 365
Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn Gly Ala Gly
    370                 375                 380
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
385                 390                 395                 400
Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg Arg
                405                 410                 415
Phe Thr His Gln Ser Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys
            420                 425                 430
Ser Arg Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr Leu Ala Pro Lys
        435                 440                 445
Asn Pro Gly Thr Gly Pro Val Phe Thr Ile Ile Asn Gly Thr Leu Lys
    450                 455                 460
Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala Ala Pro Ile Leu
465                 470                 475                 480
Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr Glu Arg Glu Leu
                485                 490                 495
Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile Gly Pro Asn Gly
            500                 505                 510
Val Leu Arg Thr Ser Leu Gly Tyr Lys Phe Pro Leu Tyr Met Ile Gly
        515                 520                 525
His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val
    530                 535                 540
Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp
545                 550                 555                 560
Glu Thr Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu
                565                 570                 575
Phe Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe
            580                 585                 590
Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val
        595                 600                 605
Gly Ile Tyr Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile
    610                 615                 620
Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys
625                 630                 635

<210> 148
<211> 630
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-HER2 PAA - membrane anchored
      
      

<400> 148
Leu Gly Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg
 1               5                  10                  15
Gly Arg Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg
            20                  25                  30
Gly Ser Arg Pro Gly Pro Ala Gly Thr Lys Cys Leu Leu Tyr Leu Ala
        35                  40                  45
Phe Leu Phe Ile Gly Val Asn Cys Lys Phe Tyr Pro Ser Tyr His Ser
    50                  55                  60
Thr Pro Gln Arg Pro Lys Phe Thr Ile Leu Phe Pro His Asn Gln Lys
65                  70                  75                  80
Gly Asn Trp Lys Asn Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser
                85                  90                  95
Ser Asp Leu Asn Trp His Asn Asp Leu Ile Gly Thr Ala Ile Gln Val
            100                 105                 110
Lys Met Pro Lys Ser His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys
        115                 120                 125
His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro
    130                 135                 140
Lys Tyr Ile Thr Gln Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln
145                 150                 155                 160
Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro
                165                 170                 175
Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu
            180                 185                 190
Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr
        195                 200                 205
Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn
    210                 215                 220
Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr
225                 230                 235                 240
Lys Val Lys Gly Ser Arg Val Val Gln Gly Asn Leu Glu Leu Thr Tyr
                245                 250                 255
Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gly Gly Gly
            260                 265                 270
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Leu Ile Ala
        275                 280                 285
His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val Arg
    290                 295                 300
Gly Thr Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
305                 310                 315                 320
Gly Ser Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp
                325                 330                 335
Gly Asp Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
            340                 345                 350
Gly Gly Ser Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val
        355                 360                 365
Ile Arg Gly Arg Ile Leu His Asn Gly Ala Gly Gly Gly Gly Ser Gly
    370                 375                 380
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Lys Val Pro Ile Lys
385                 390                 395                 400
Trp Met Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe Thr His Gln Ser
                405                 410                 415
Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys Ser Arg Leu Pro Ile
            420                 425                 430
Ser Pro Val Asp Leu Ser Tyr Leu Ala Pro Lys Asn Pro Gly Thr Gly
        435                 440                 445
Pro Val Phe Thr Ile Ile Asn Gly Thr Leu Lys Tyr Phe Glu Thr Arg
    450                 455                 460
Tyr Ile Arg Val Asp Ile Ala Ala Pro Ile Leu Ser Arg Met Val Gly
465                 470                 475                 480
Met Ile Ser Gly Thr Thr Thr Glu Arg Glu Leu Trp Asp Asp Trp Ala
                485                 490                 495
Pro Tyr Glu Asp Val Glu Ile Gly Pro Asn Gly Val Leu Arg Thr Ser
            500                 505                 510
Leu Gly Tyr Lys Phe Pro Leu Tyr Met Ile Gly His Gly Met Leu Asp
        515                 520                 525
Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His
    530                 535                 540
Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Thr Leu Phe Phe
545                 550                 555                 560
Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Phe Val Glu Gly Trp
                565                 570                 575
Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly
            580                 585                 590
Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile Tyr Leu Cys
        595                 600                 605
Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu
    610                 615                 620
Met Asn Arg Leu Gly Lys
625                 630

<210> 149
<211> 1630
<212> DNA
<213> Artificial Sequence

<220> 
<223> MTI-HER2 PAA - membrane anchored variant 2
      
      

<400> 149
gggtggagat gtagaagatg tgacgccgcg gcccggcggg tgccagatta gcggacgcgg      60
tgcccgcggt tgcaacggga tcccgggcgc tgcagcttgg gaggcggctc tccccaggcg     120
gcgtccgcgg agacacccat ccgtgaaccc caggtcccgg gccgccggct cgccgcgcac     180
caggggccgg cggacagaag agcggccgag cggctcgagg ctgggggacc gcgggcgcgg     240
ccgcgcgctg ccgggcggga ggctgggggg ccggggccgg ggccgtgccc cggagcgggt     300
cggaggccgg ggccggggcc gggggacggc ggctccccgc gcggctccag cggctcgggg     360
atcccggccg ggccccgcag ggaccaagtg ccttttgtac ttagcctttt tattcattgg     420
ggtgaattgc aagttttacc cttcttatca ctctacccca cagcggcctt ctagagtggt     480
gcagggcaac ctggagctga cctacctgcc caccaacgcc agcctgagct tcctgcagga     540
catcggcggc ggcggcagcg gcggcggcgg cagcggcggc ggcggcagcg tgctgatcgc     600
ccacaaccag gtgagacagg tgcccctgca gagactgaga atcgtgagag gcacccaggg     660
cggcggcggc agcggcggcg gcggcagcgg cggcggcggc agcaagatct tcggcagcct     720
ggccttcctg cccgagagct tcgacggcga ccccgccggc ggcggcggca gcggcggcgg     780
cggcagcggc ggcggcggca gcagcctgcc cgacctgagc gtgttccaga acctgcaggt     840
gatcagaggc agaatcctgc acaacggcgc cggcggcggc ggcagcggcg gcggcggcag     900
cggcggcggc ggcagcggcg gcaaggtgcc catcaagtgg atggccctgg agagcatcct     960
gagaagaaga ttcacccacc agagctacac cgacatcgag atgaacagac tgggcaagtc    1020
tagacttccc atctctccag tggatctcag ctatcttgct cctaaaaacc caggaaccgg    1080
tcctgtcttt accataatca atggtaccct aaaatacttt gagaccagat acatcagagt    1140
cgatattgct gctccaatcc tctcaagaat ggtcggaatg atcagtggaa ctaccacaga    1200
aagggaactg tgggatgact gggctccata tgaagacgtg gaaattggac ccaatggagt    1260
tctgaggacc agtttaggat ataagtttcc tttatatatg attggacatg gtatgttgga    1320
ctccgatctt catcttagct caaaggctca ggtgtttgaa catcctcaca ttcaagacgc    1380
tgcttcgcag cttcctgatg atgagacttt attttttggt gatactgggc tatccaaaaa    1440
tccaatcgag tttgtagaag gttggttcag tagttggaag agctctattg cctctttttt    1500
ctttatcata gggttaatca ttggactatt cttggttctc cgagttggta tttatctttg    1560
cattaaatta aagcacacca agaaaagaca gatttataca gacatagaga tgaaccgact    1620
tggaaagtaa                                                           1630

<210> 150
<211> 469
<212> PRT
<213> Artificial Sequence

<220> 
<223> MTI-HER2 PAA - membrane anchored variant 2
      
      

<400> 150
Met Gly Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly
 1               5                  10                  15
Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg
            20                  25                  30
Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser
        35                  40                  45
Arg Pro Gly Pro Ala Gly Thr Lys Cys Leu Leu Tyr Leu Ala Phe Leu
    50                  55                  60
Phe Ile Gly Val Asn Cys Lys Phe Tyr Pro Ser Tyr His Ser Thr Pro
65                  70                  75                  80
Gln Arg Pro Ser Arg Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu
                85                  90                  95
Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gly Gly Gly Gly
            100                 105                 110
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Leu Ile Ala His
        115                 120                 125
Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val Arg Gly
    130                 135                 140
Thr Gln Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
145                 150                 155                 160
Ser Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly
                165                 170                 175
Asp Pro Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
            180                 185                 190
Gly Ser Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile
        195                 200                 205
Arg Gly Arg Ile Leu His Asn Gly Ala Gly Gly Gly Gly Ser Gly Gly
    210                 215                 220
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Lys Val Pro Ile Lys Trp
225                 230                 235                 240
Met Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe Thr His Gln Ser Tyr
                245                 250                 255
Thr Asp Ile Glu Met Asn Arg Leu Gly Lys Ser Arg Leu Pro Ile Ser
            260                 265                 270
Pro Val Asp Leu Ser Tyr Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro
        275                 280                 285
Val Phe Thr Ile Ile Asn Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr
    290                 295                 300
Ile Arg Val Asp Ile Ala Ala Pro Ile Leu Ser Arg Met Val Gly Met
305                 310                 315                 320
Ile Ser Gly Thr Thr Thr Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro
                325                 330                 335
Tyr Glu Asp Val Glu Ile Gly Pro Asn Gly Val Leu Arg Thr Ser Leu
            340                 345                 350
Gly Tyr Lys Phe Pro Leu Tyr Met Ile Gly His Gly Met Leu Asp Ser
        355                 360                 365
Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile
    370                 375                 380
Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Thr Leu Phe Phe Gly
385                 390                 395                 400
Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Phe Val Glu Gly Trp Phe
                405                 410                 415
Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu
            420                 425                 430
Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile Tyr Leu Cys Ile
        435                 440                 445
Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met
    450                 455                 460
Asn Arg Leu Gly Lys
465

<210> 151
<211> 4304
<212> DNA
<213> Homo sapiens

<400> 151
cacacggact acaggggagt tttgttgaag ttgcaaagtc ctggagcctc cagagggctg      60
tcggcgcagt agcagcgagc agcagagtcc gcacgctccg gcgaggggca gaagagcgcg     120
agggagcgcg gggcagcaga agcgagagcc gagcgcggac ccagccagga cccacagccc     180
tccccagctg cccaggaaga gccccagcca tggaacacca gctcctgtgc tgcgaagtgg     240
aaaccatccg ccgcgcgtac cccgatgcca acctcctcaa cgaccgggtg ctgcgggcca     300
tgctgaaggc ggaggagacc tgcgcgccct cggtgtccta cttcaaatgt gtgcagaagg     360
aggtcctgcc gtccatgcgg aagatcgtcg ccacctggat gctggaggtc tgcgaggaac     420
agaagtgcga ggaggaggtc ttcccgctgg ccatgaacta cctggaccgc ttcctgtcgc     480
tggagcccgt gaaaaagagc cgcctgcagc tgctgggggc cacttgcatg ttcgtggcct     540
ctaagatgaa ggagaccatc cccctgacgg ccgagaagct gtgcatctac accgacaact     600
ccatccggcc cgaggagctg ctgcaaatgg agctgctcct ggtgaacaag ctcaagtgga     660
acctggccgc aatgaccccg cacgatttca ttgaacactt cctctccaaa atgccagagg     720
cggaggagaa caaacagatc atccgcaaac acgcgcagac cttcgttgcc ctctgtgcca     780
cagatgtgaa gttcatttcc aatccgccct ccatggtggc agcggggagc gtggtggccg     840
cagtgcaagg cctgaacctg aggagcccca acaacttcct gtcctactac cgcctcacac     900
gcttcctctc cagagtgatc aagtgtgacc cggactgcct ccgggcctgc caggagcaga     960
tcgaagccct gctggagtca agcctgcgcc aggcccagca gaacatggac cccaaggccg    1020
ccgaggagga ggaagaggag gaggaggagg tggacctggc ttgcacaccc accgacgtgc    1080
gggacgtgga catctgaggg cgccaggcag gcgggcgcca ccgccacccg cagcgagggc    1140
ggagccggcc ccaggtgctc ccctgacagt ccctcctctc cggagcattt tgataccaga    1200
agggaaagct tcattctcct tgttgttggt tgttttttcc tttgctcttt cccccttcca    1260
tctctgactt aagcaaaaga aaaagattac ccaaaaactg tctttaaaag agagagagag    1320
aaaaaaaaaa tagtatttgc ataaccctga gcggtggggg aggagggttg tgctacagat    1380
gatagaggat tttatacccc aataatcaac tcgtttttat attaatgtac ttgtttctct    1440
gttgtaagaa taggcattaa cacaaaggag gcgtctcggg agaggattag gttccatcct    1500
ttacgtgttt aaaaaaaagc ataaaaacat tttaaaaaca tagaaaaatt cagcaaacca    1560
tttttaaagt agaagagggt tttaggtaga aaaacatatt cttgtgcttt tcctgataaa    1620
gcacagctgt agtggggttc taggcatctc tgtactttgc ttgctcatat gcatgtagtc    1680
actttataag tcattgtatg ttattatatt ccgtaggtag atgtgtaacc tcttcacctt    1740
attcatggct gaagtcacct cttggttaca gtagcgtagc gtgcccgtgt gcatgtcctt    1800
tgcgcctgtg accaccaccc caacaaacca tccagtgaca aaccatccag tggaggtttg    1860
tcgggcacca gccagcgtag cagggtcggg aaaggccacc tgtcccactc ctacgatacg    1920
ctactataaa gagaagacga aatagtgaca taatatattc tatttttata ctcttcctat    1980
ttttgtagtg acctgtttat gagatgctgg ttttctaccc aacggccctg cagccagctc    2040
acgtccaggt tcaacccaca gctacttggt ttgtgttctt cttcatattc taaaaccatt    2100
ccatttccaa gcactttcag tccaataggt gtaggaaata gcgctgtttt tgttgtgtgt    2160
gcagggaggg cagttttcta atggaatggt ttgggaatat ccatgtactt gtttgcaagc    2220
aggactttga ggcaagtgtg ggccactgtg gtggcagtgg aggtggggtg tttgggaggc    2280
tgcgtgccag tcaagaagaa aaaggtttgc attctcacat tgccaggatg ataagttcct    2340
ttccttttct ttaaagaagt tgaagtttag gaatcctttg gtgccaactg gtgtttgaaa    2400
gtagggacct cagaggttta cctagagaac aggtggtttt taagggttat cttagatgtt    2460
tcacaccgga aggtttttaa acactaaaat atataattta tagttaaggc taaaaagtat    2520
atttattgca gaggatgttc ataaggccag tatgatttat aaatgcaatc tccccttgat    2580
ttaaacacac agatacacac acacacacac acacacacaa accttctgcc tttgatgtta    2640
cagatttaat acagtttatt tttaaagata gatcctttta taggtgagaa aaaaacaatc    2700
tggaagaaaa aaaccacaca aagacattga ttcagcctgt ttggcgtttc ccagagtcat    2760
ctgattggac aggcatgggt gcaaggaaaa ttagggtact caacctaagt tcggttccga    2820
tgaattctta tcccctgccc cttcctttaa aaaacttagt gacaaaatag acaatttgca    2880
catcttggct atgtaattct tgtaattttt atttaggaag tgttgaaggg aggtggcaag    2940
agtgtggagg ctgacgtgtg agggaggaca ggcgggagga ggtgtgagga ggaggctccc    3000
gaggggaagg ggcggtgccc acaccgggga caggccgcag ctccattttc ttattgcgct    3060
gctaccgttg acttccaggc acggtttgga aatattcaca tcgcttctgt gtatctcttt    3120
cacattgttt gctgctattg gaggatcagt tttttgtttt acaatgtcat atactgccat    3180
gtactagttt tagttttctc ttagaacatt gtattacaga tgcctttttt gtagtttttt    3240
ttttttttat gtgatcaatt ttgacttaat gtgattactg ctctattcca aaaaggttgc    3300
tgtttcacaa tacctcatgc ttcacttagc catggtggac ccagcgggca ggttctgcct    3360
gctttggcgg gcagacacgc gggcgcgatc ccacacaggc tggcgggggc cggccccgag    3420
gccgcgtgcg tgagaaccgc gccggtgtcc ccagagacca ggctgtgtcc ctcttctctt    3480
ccctgcgcct gtgatgctgg gcacttcatc tgatcggggg cgtagcatca tagtagtttt    3540
tacagctgtg ttattctttg cgtgtagcta tggaagttgc ataattatta ttattattat    3600
tataacaagt gtgtcttacg tgccaccacg gcgttgtacc tgtaggactc tcattcggga    3660
tgattggaat agcttctgga atttgttcaa gttttgggta tgtttaatct gttatgtact    3720
agtgttctgt ttgttattgt tttgttaatt acaccataat gctaatttaa agagactcca    3780
aatctcaatg aagccagctc acagtgctgt gtgccccggt cacctagcaa gctgccgaac    3840
caaaagaatt tgcaccccgc tgcgggccca cgtggttggg gccctgccct ggcagggtca    3900
tcctgtgctc ggaggccatc tcgggcacag gcccaccccg ccccacccct ccagaacacg    3960
gctcacgctt acctcaacca tcctggctgc ggcgtctgtc tgaaccacgc gggggccttg    4020
agggacgctt tgtctgtcgt gatggggcaa gggcacaagt cctggatgtt gtgtgtatcg    4080
agaggccaaa ggctggtggc aagtgcacgg ggcacagcgg agtctgtcct gtgacgcgca    4140
agtctgaggg tctgggcggc gggcggctgg gtctgtgcat ttctggttgc accgcggcgc    4200
ttcccagcac caacatgtaa ccggcatgtt tccagcagaa gacaaaaaga caaacatgaa    4260
agtctagaaa taaaactggt aaaaccccaa aaaaaaaaaa aaaa                     4304

<210> 152
<211> 295
<212> PRT
<213> Homo sapiens

<400> 152
Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala
 1               5                  10                  15
Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu
            20                  25                  30
Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val
        35                  40                  45
Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met
    50                  55                  60
Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu
65                  70                  75                  80
Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys
                85                  90                  95
Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys
            100                 105                 110
Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr
        115                 120                 125
Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu
    130                 135                 140
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe
145                 150                 155                 160
Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln
                165                 170                 175
Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr Asp
            180                 185                 190
Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val
        195                 200                 205
Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu
    210                 215                 220
Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp
225                 230                 235                 240
Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu
                245                 250                 255
Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu
            260                 265                 270
Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr
        275                 280                 285
Asp Val Arg Asp Val Asp Ile
    290                 295

<210> 153
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II Cyclin D1
      

<400> 153
His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala Tyr
 1               5                  10                  15

<210> 154
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II Cyclin D1
      

<400> 154
Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp
 1               5                  10                  15

<210> 155
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II Cyclin D1
      

<400> 155
Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met Leu Glu Val
 1               5                  10                  15

<210> 156
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II Cyclin D1
      

<400> 156
Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys
 1               5                  10

<210> 157
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II Cyclin D1
      

<400> 157
Leu Leu Gln Met Glu Leu Leu Leu Val Asn Lys Leu
 1               5                  10

<210> 158
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II Cyclin D1
      

<400> 158
Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp
 1               5                  10                  15

<210> 159
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II Cyclin D1
      

<400> 159
Asn Lys Gln Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu
 1               5                  10                  15

<210> 160
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II Cyclin D1
      

<400> 160
Pro Pro Ser Met Val Ala Ala Gly Ser Val Val Ala Ala Val Gln
 1               5                  10                  15

<210> 161
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 161
Glu Val Glu Thr Ile Arg Arg Ala Tyr
 1               5

<210> 162
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 162
Leu Leu Cys Cys Glu Val Glu Thr Ile
 1               5

<210> 163
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 163
Lys Glu Val Leu Pro Ser Met Arg Lys
 1               5

<210> 164
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 164
Glu Val Leu Pro Ser Met Arg Lys Ile
 1               5

<210> 165
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 165
Leu Pro Ser Met Arg Lys Ile Val Ala
 1               5

<210> 166
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 166
Ser Met Arg Lys Ile Val Ala Thr Trp
 1               5

<210> 167
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 167
Ile Val Ala Thr Trp Met Leu Glu Val
 1               5

<210> 168
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 168
Leu Pro Ser Met Arg Lys Ile Val Ala
 1               5

<210> 169
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 169
Arg Lys Ile Val Ala Thr Trp Met Leu
 1               5

<210> 170
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 170
Met Arg Lys Ile Val Ala Thr Trp Met
 1               5

<210> 171
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 171
Ser Met Arg Lys Ile Val Ala Thr Trp
 1               5

<210> 172
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 172
Leu Leu Gly Ala Thr Cys Met Phe Val
 1               5

<210> 173
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 173
Ala Thr Cys Met Phe Val Ala Ser Lys
 1               5

<210> 174
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 174
Gln Leu Leu Gly Ala Thr Cys Met Phe
 1               5

<210> 175
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 175
Leu Gln Leu Leu Gly Ala Thr Cys Met
 1               5

<210> 176
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 176
Leu Leu Gln Met Glu Leu Leu Leu Val
 1               5

<210> 177
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 177
Gln Met Glu Leu Leu Leu Val Asn Lys
 1               5

<210> 178
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 178
Met Glu Leu Leu Leu Val Asn Lys Leu
 1               5

<210> 179
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 179
Lys Leu Lys Trp Asn Leu Ala Ala Met
 1               5

<210> 180
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 180
Lys His Ala Gln Thr Phe Val Ala Leu
 1               5

<210> 181
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 181
Ile Ile Arg Lys His Ala Gln Thr Phe
 1               5

<210> 182
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 182
Gln Ile Ile Arg Lys His Ala Gln Thr
 1               5

<210> 183
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I Cyclin D1
      

<400> 183
Ser Met Val Ala Ala Gly Ser Val Val
 1               5

<210> 184
<211> 3490
<212> DNA
<213> Homo sapiens

<400> 184
gaagagactc agggcagagg gaggaaggac agcagaccag acagtcacag cagccttgac      60
aaaacgttcc tggaactcaa gctcttctcc acagaggagg acagagcaga cagcagagac     120
catggagtct ccctcggccc ctccccacag atggtgcatc ccctggcaga ggctcctgct     180
cacagcctca cttctaacct tctggaaccc gcccaccact gccaagctca ctattgaatc     240
cacgccgttc aatgtcgcag aggggaagga ggtgcttcta cttgtccaca atctgcccca     300
gcatcttttt ggctacagct ggtacaaagg tgaaagagtg gatggcaacc gtcaaattat     360
aggatatgta ataggaactc aacaagctac cccagggccc gcatacagtg gtcgagagat     420
aatatacccc aatgcatccc tgctgatcca gaacatcatc cagaatgaca caggattcta     480
caccctacac gtcataaagt cagatcttgt gaatgaagaa gcaactggcc agttccgggt     540
atacccggag ctgcccaagc cctccatctc cagcaacaac tccaaacccg tggaggacaa     600
ggatgctgtg gccttcacct gtgaacctga gactcaggac gcaacctacc tgtggtgggt     660
aaacaatcag agcctcccgg tcagtcccag gctgcagctg tccaatggca acaggaccct     720
cactctattc aatgtcacaa gaaatgacac agcaagctac aaatgtgaaa cccagaaccc     780
agtgagtgcc aggcgcagtg attcagtcat cctgaatgtc ctctatggcc cggatgcccc     840
caccatttcc cctctaaaca catcttacag atcaggggaa aatctgaacc tctcctgcca     900
cgcagcctct aacccacctg cacagtactc ttggtttgtc aatgggactt tccagcaatc     960
cacccaagag ctctttatcc ccaacatcac tgtgaataat agtggatcct atacgtgcca    1020
agcccataac tcagacactg gcctcaatag gaccacagtc acgacgatca cagtctatgc    1080
agagccaccc aaacccttca tcaccagcaa caactccaac cccgtggagg atgaggatgc    1140
tgtagcctta acctgtgaac ctgagattca gaacacaacc tacctgtggt gggtaaataa    1200
tcagagcctc ccggtcagtc ccaggctgca gctgtccaat gacaacagga ccctcactct    1260
actcagtgtc acaaggaatg atgtaggacc ctatgagtgt ggaatccaga acgaattaag    1320
tgttgaccac agcgacccag tcatcctgaa tgtcctctat ggcccagacg accccaccat    1380
ttccccctca tacacctatt accgtccagg ggtgaacctc agcctctcct gccatgcagc    1440
ctctaaccca cctgcacagt attcttggct gattgatggg aacatccagc aacacacaca    1500
agagctcttt atctccaaca tcactgagaa gaacagcgga ctctatacct gccaggccaa    1560
taactcagcc agtggccaca gcaggactac agtcaagaca atcacagtct ctgcggagct    1620
gcccaagccc tccatctcca gcaacaactc caaacccgtg gaggacaagg atgctgtggc    1680
cttcacctgt gaacctgagg ctcagaacac aacctacctg tggtgggtaa atggtcagag    1740
cctcccagtc agtcccaggc tgcagctgtc caatggcaac aggaccctca ctctattcaa    1800
tgtcacaaga aatgacgcaa gagcctatgt atgtggaatc cagaactcag tgagtgcaaa    1860
ccgcagtgac ccagtcaccc tggatgtcct ctatgggccg gacaccccca tcatttcccc    1920
cccagactcg tcttaccttt cgggagcgaa cctcaacctc tcctgccact cggcctctaa    1980
cccatccccg cagtattctt ggcgtatcaa tgggataccg cagcaacaca cacaagttct    2040
ctttatcgcc aaaatcacgc caaataataa cgggacctat gcctgttttg tctctaactt    2100
ggctactggc cgcaataatt ccatagtcaa gagcatcaca gtctctgcat ctggaacttc    2160
tcctggtctc tcagctgggg ccactgtcgg catcatgatt ggagtgctgg ttggggttgc    2220
tctgatatag cagccctggt gtagtttctt catttcagga agactgcatt tgcaacagct    2280
acagtctaaa attgcttctt taccaaggat atttacagaa aagactctga ccagagatcg    2340
agaccatcct agccaacatc gtgaaacccc atctctacta aaaatacaaa aatgagctgg    2400
gcttggtggc gcacacctgt agtcccagtt actcgggagg ctgaggcagg agaatcgctt    2460
gaacccggga ggtggagatt gcagtgagcc cagatcgcac cactgcactc cagtctggca    2520
acagagcaag actccatctc aaaaagaaaa gaaaagaaga ctctgacctg tactcttgaa    2580
tacaagtttc tgataccact gcactgtctg agaatttcca aaactttaat gaactaactg    2640
acagcttcat gaaactgtcc accaagatca agcagagaaa ataattaatt tcatgggact    2700
aaatgaacta atgaggataa tattttcata attttttatt tgaaattttg ctgattcttt    2760
aaatgtcttg tttcccagat ttcaggaaac tttttttctt ttaagctatc cacagcttac    2820
agcaatttga taaaatatac ttttgtgaac aaaaattgag acatttacat tttctcccta    2880
tgtggtcgct ccagacttgg gaaactattc atgaatattt atattgtatg gtaatatagt    2940
tattgcacaa gttcaataaa aatctgctct ttgtatgaca gaatacattt gaaaacattg    3000
gttatattac caagactttg actagaatgt cgtatttgag gatataaacc cataggtaat    3060
aaacccacag gtactacaaa caaagtctga agtcagcctt ggtttggctt cctagtgtca    3120
attaaacttc taaaagttta atctgagatt ccttataaaa acttccagca aagcaacttt    3180
aaaaaagtct gtgtgggccg ggcgcggtgg ctcacgcctg taatcccagc actttgatcc    3240
gccgaggcgg gcggatcacg aggtcaggag atccagacca tcctggctaa cacagtgaaa    3300
ccccgtctct actaaaaata caaaaaaagt tagccgggcg tggtggtggg ggcctgtagt    3360
cccagctact caggaggctg aggcaggaga acggcatgaa cccgggaggc agggcttgca    3420
gtgagccaag atcatgccgc tgcactccag cctgggagac aaagtgagac tccgtcaaaa    3480
aaaaaaaaaa                                                           3490

<210> 185
<211> 702
<212> PRT
<213> Homo sapiens

<400> 185
Met Glu Ser Pro Ser Ala Pro Pro His Arg Trp Cys Ile Pro Trp Gln
 1               5                  10                  15
Arg Leu Leu Leu Thr Ala Ser Leu Leu Thr Phe Trp Asn Pro Pro Thr
            20                  25                  30
Thr Ala Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly
        35                  40                  45
Lys Glu Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly
    50                  55                  60
Tyr Ser Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile
65                  70                  75                  80
Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser
                85                  90                  95
Gly Arg Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile
            100                 105                 110
Ile Gln Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp
        115                 120                 125
Leu Val Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu
    130                 135                 140
Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys
145                 150                 155                 160
Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr
                165                 170                 175
Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln
            180                 185                 190
Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn
        195                 200                 205
Asp Thr Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg
    210                 215                 220
Arg Ser Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Ala Pro
225                 230                 235                 240
Thr Ile Ser Pro Leu Asn Thr Ser Tyr Arg Ser Gly Glu Asn Leu Asn
                245                 250                 255
Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser Trp Phe
            260                 265                 270
Val Asn Gly Thr Phe Gln Gln Ser Thr Gln Glu Leu Phe Ile Pro Asn
        275                 280                 285
Ile Thr Val Asn Asn Ser Gly Ser Tyr Thr Cys Gln Ala His Asn Ser
    290                 295                 300
Asp Thr Gly Leu Asn Arg Thr Thr Val Thr Thr Ile Thr Val Tyr Ala
305                 310                 315                 320
Glu Pro Pro Lys Pro Phe Ile Thr Ser Asn Asn Ser Asn Pro Val Glu
                325                 330                 335
Asp Glu Asp Ala Val Ala Leu Thr Cys Glu Pro Glu Ile Gln Asn Thr
            340                 345                 350
Thr Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg
        355                 360                 365
Leu Gln Leu Ser Asn Asp Asn Arg Thr Leu Thr Leu Leu Ser Val Thr
    370                 375                 380
Arg Asn Asp Val Gly Pro Tyr Glu Cys Gly Ile Gln Asn Glu Leu Ser
385                 390                 395                 400
Val Asp His Ser Asp Pro Val Ile Leu Asn Val Leu Tyr Gly Pro Asp
                405                 410                 415
Asp Pro Thr Ile Ser Pro Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn
            420                 425                 430
Leu Ser Leu Ser Cys His Ala Ala Ser Asn Pro Pro Ala Gln Tyr Ser
        435                 440                 445
Trp Leu Ile Asp Gly Asn Ile Gln Gln His Thr Gln Glu Leu Phe Ile
    450                 455                 460
Ser Asn Ile Thr Glu Lys Asn Ser Gly Leu Tyr Thr Cys Gln Ala Asn
465                 470                 475                 480
Asn Ser Ala Ser Gly His Ser Arg Thr Thr Val Lys Thr Ile Thr Val
                485                 490                 495
Ser Ala Glu Leu Pro Lys Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro
            500                 505                 510
Val Glu Asp Lys Asp Ala Val Ala Phe Thr Cys Glu Pro Glu Ala Gln
        515                 520                 525
Asn Thr Thr Tyr Leu Trp Trp Val Asn Gly Gln Ser Leu Pro Val Ser
    530                 535                 540
Pro Arg Leu Gln Leu Ser Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn
545                 550                 555                 560
Val Thr Arg Asn Asp Ala Arg Ala Tyr Val Cys Gly Ile Gln Asn Ser
                565                 570                 575
Val Ser Ala Asn Arg Ser Asp Pro Val Thr Leu Asp Val Leu Tyr Gly
            580                 585                 590
Pro Asp Thr Pro Ile Ile Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly
        595                 600                 605
Ala Asn Leu Asn Leu Ser Cys His Ser Ala Ser Asn Pro Ser Pro Gln
    610                 615                 620
Tyr Ser Trp Arg Ile Asn Gly Ile Pro Gln Gln His Thr Gln Val Leu
625                 630                 635                 640
Phe Ile Ala Lys Ile Thr Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe
                645                 650                 655
Val Ser Asn Leu Ala Thr Gly Arg Asn Asn Ser Ile Val Lys Ser Ile
            660                 665                 670
Thr Val Ser Ala Ser Gly Thr Ser Pro Gly Leu Ser Ala Gly Ala Thr
        675                 680                 685
Val Gly Ile Met Ile Gly Val Leu Val Gly Val Ala Leu Ile
    690                 695                 700

<210> 186
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II CEA

<400> 186
Leu Leu Thr Phe Trp Asn Pro Pro Thr Thr Ala Lys Leu Thr Ile
 1               5                  10                  15

<210> 187
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II CEA

<400> 187
Asn Arg Gln Ile Ile Gly Tyr Val Ile Gly Thr Gln Gln Ala Thr
 1               5                  10                  15

<210> 188
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II CEA

<400> 188
Tyr Leu Trp Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg
 1               5                  10                  15

<210> 189
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II CEA

<400> 189
Ser Tyr Thr Tyr Tyr Arg Pro Gly Val Asn Leu Ser Leu Ser Cys
 1               5                  10                  15

<210> 190
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II CEA

<400> 190
Arg Thr Thr Val Lys Thr Ile Thr Val Ser Ala Glu Leu Pro Lys
 1               5                  10                  15

<210> 191
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class II CEA

<400> 191
Asn Gly Thr Tyr Ala Cys Phe Val Ser Asn Leu Ala Thr Gly Arg
 1               5                  10                  15

<210> 192
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I CEA

<400> 192
Leu Leu Thr Phe Trp Asn Pro Pro Thr
 1               5

<210> 193
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I CEA

<400> 193
Pro Pro Thr Thr Ala Lys Leu Thr Ile
 1               5

<210> 194
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I CEA

<400> 194
Tyr Val Ile Gly Thr Gln Gln Ala Thr
 1               5

<210> 195
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I CEA

<400> 195
Asn Arg Gln Ile Ile Gly Tyr Val Ile
 1               5

<210> 196
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I CEA

<400> 196
Leu Trp Trp Val Asn Asn Gln Ser Leu
 1               5

<210> 197
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I CEA

<400> 197
Thr Tyr Tyr Arg Pro Gly Val Asn Leu
 1               5

<210> 198
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I CEA

<400> 198
Tyr Arg Pro Gly Val Asn Leu Ser Leu
 1               5

<210> 199
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I CEA

<400> 199
Lys Thr Ile Thr Val Ser Ala Glu Leu
 1               5

<210> 200
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I CEA

<400> 200
Ile Thr Val Ser Ala Glu Leu Pro Lys
 1               5

<210> 201
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I CEA

<400> 201
Phe Val Ser Asn Leu Ala Thr Gly Arg
 1               5

<210> 202
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Class I CEA

<400> 202
Thr Tyr Ala Cys Phe Val Ser Asn Leu
 1               5

<210> 203
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> consensus ubiqutination motif

<400> 203
Lys Glu Glu Glu
 1

<210> 204
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Small pox PAA

<400> 204
Glu Val Asn Thr Ile Leu Met Asp Asn Lys Gly Leu Gly Val Arg Leu
 1               5                  10                  15
Ala Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ser Leu Thr
            20                  25                  30
Ile Leu Asp Asp Asn Leu Tyr Lys Val Tyr Asn Gly Ile Gly Gly Gly
        35                  40                  45
Gly Ser Gly Gly Gly Gly Ser Arg Thr Asp Asp Gly Leu Leu Asp Arg
    50                  55                  60
Leu Tyr Asp Leu Thr Arg Tyr Ala Gly Gly Gly Gly Ser Gly Gly Gly
65                  70                  75                  80
Gly Ser Pro Leu Thr Lys Gly Ile Leu Gly Val Phe Thr Leu Thr Val
                85                  90                  95
Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ile Val Asn
            100                 105                 110
Ser Leu Ser Asn Leu Asp Phe Arg Leu
        115                 120

<210> 205
<211> 194
<212> PRT
<213> Artificial Sequence

<220> 
<223> Smallpox MTI-PAA + VSV-G epitope tag

<400> 205
Met Gly Asp Arg Gly Arg Gly Arg Ala Leu Pro Gly Gly Arg Leu Gly
 1               5                  10                  15
Gly Arg Gly Arg Gly Arg Ala Pro Glu Arg Val Gly Gly Arg Gly Arg
            20                  25                  30
Gly Arg Gly Thr Ala Ala Pro Arg Ala Ala Pro Ala Ala Arg Gly Ser
        35                  40                  45
Arg Pro Gly Pro Ala Gly Thr Met Ala Ala Gly Ser Ser Arg Glu Val
    50                  55                  60
Asn Thr Ile Leu Met Asp Asn Lys Gly Leu Gly Val Arg Leu Ala Thr
65                  70                  75                  80
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ser Leu Thr Ile Leu
                85                  90                  95
Asp Asp Asn Leu Tyr Lys Val Tyr Asn Gly Ile Gly Gly Gly Gly Ser
            100                 105                 110
Gly Gly Gly Gly Ser Arg Thr Asp Asp Gly Leu Leu Asp Arg Leu Tyr
        115                 120                 125
Asp Leu Thr Arg Tyr Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
    130                 135                 140
Pro Leu Thr Lys Gly Ile Leu Gly Val Phe Thr Leu Thr Val Pro Ser
145                 150                 155                 160
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ile Val Asn Ser Leu
                165                 170                 175
Ser Asn Leu Asp Phe Arg Leu Tyr Thr Asp Ile Glu Met Asn Arg Leu
            180                 185                 190
Gly Lys


<210> 206
<211> 2974
<212> DNA
<213> Homo sapiens

<400> 206
gtgtgcgtga tggagaaaat tgggcaccag ggctgctccc gagattctca gatctgattt      60
ccacgcttgc taccaaaata gtctgggcag gccacttttg gaagtaggcg ttatctagtg     120
agcaggcggc cgctttcgat ttcgctttcc cctaaatggc tgagcttctc gccagcgcag     180
gatcagcctg ttcctgggac tttccgagag ccccgccctc gttccctccc ccagccgcca     240
gtaggggagg actcggcggt acccggagct tcaggcccca ccggggcgcg gagagtccca     300
ggcccggccg ggaccgggac ggcgtccgag tgccaatggc tagctctagg tgtcccgctc     360
cccgcgggtg ccgctgcctc cccggagctt ctctcgcatg gctggggaca gtactgctac     420
ttctcgccga ctgggtgctg ctccggaccg cgctgccccg catattctcc ctgctggtgc     480
ccaccgcgct gccactgctc cgggtctggg cggtgggcct gagccgctgg gccgtgctct     540
ggctgggggc ctgcggggtc ctcagggcaa cggttggctc caagagcgaa aacgcaggtg     600
cccagggctg gctggctgct ttgaagccat tagctgcggc actgggcttg gccctgccgg     660
gacttgcctt gttccgagag ctgatctcat ggggagcccc cgggtccgcg gatagcacca     720
ggctactgca ctggggaagt caccctaccg ccttcgttgt cagttatgca gcggcactgc     780
ccgcagcagc cctgtggcac aaactcggga gcctctgggt gcccggcggt cagggcggct     840
ctggaaaccc tgtgcgtcgg cttctaggct gcctgggctc ggagacgcgc cgcctctcgc     900
tgttcctggt cctggtggtc ctctcctctc ttggggagat ggccattcca ttctttacgg     960
gccgcctcac tgactggatt ctacaagatg gctcagccga taccttcact cgaaacttaa    1020
ctctcatgtc cattctcacc atagccagtg cagtgctgga gttcgtgggt gacgggatct    1080
ataacaacac catgggccac gtgcacagcc acttgcaggg agaggtgttt ggggctgtcc    1140
tgcgccagga gacggagttt ttccaacaga accagacagg taacatcatg tctcgggtaa    1200
cagaggacac gtccaccctg agtgattctc tgagtgagaa tctgagctta tttctgtggt    1260
acctggtgcg aggcctatgt ctcttgggga tcatgctctg gggatcagtg tccctcacca    1320
tggtcaccct gatcaccctg cctctgcttt tccttctgcc caagaaggtg ggaaaatggt    1380
accagttgct ggaagtgcag gtgcgggaat ctctggcaaa gtccagccag gtggccattg    1440
aggctctgtc ggccatgcct acagttcgaa gctttgccaa cgaggagggc gaagcccaga    1500
agtttaggga aaagctgcaa gaaataaaga cactcaacca gaaggaggct gtggcctatg    1560
cagtcaactc ctggaccact agtatttcag gtatgctgct gaaagtggga atcctctaca    1620
ttggtgggca gctggtgacc agtggggctg taagcagtgg gaaccttgtc acatttgttc    1680
tctaccagat gcagttcacc caggctgtgg aggtactgct ctccatctac cccagagtac    1740
agaaggctgt gggctcctca gagaaaatat ttgagtacct ggaccgcacc cctcgctgcc    1800
cacccagtgg tctgttgact cccttacact tggagggcct tgtccagttc caagatgtct    1860
cctttgccta cccaaaccgc ccagatgtct tagtgctaca ggggctgaca ttcaccctac    1920
gccctggcga ggtgacggcg ctggtgggac ccaatgggtc tgggaagagc acagtggctg    1980
ccctgctgca gaatctgtac cagcccaccg ggggacagct gctgttggat gggaagcccc    2040
ttccccaata tgagcaccgc tacctgcaca ggcaggtggc tgcagtggga caagagccac    2100
aggtatttgg aagaagtctt caagaaaata ttgcctatgg cctgacccag aagccaacta    2160
tggaggaaat cacagctgct gcagtaaagt ctggggccca tagtttcatc tctggactcc    2220
ctcagggcta tgacacagag gtagacgagg ctgggagcca gctgtcaggg ggtcagcgac    2280
aggcagtggc gttggcccga gcattgatcc ggaaaccgtg tgtacttatc ctggatgatg    2340
ccaccagtgc cctggatgca aacagccagt tacaggtgga gcagctcctg tacgaaagcc    2400
ctgagcggta ctcccgctca gtgcttctca tcacccagca cctcagcctg gtggagcagg    2460
ctgaccacat cctctttctg gaaggaggcg ctatccggga ggggggaacc caccagcagc    2520
tcatggagaa aaaggggtgc tactgggcca tggtgcaggc tcctgcagat gctccagaat    2580
gaaagccttc tcagacctgc gcactccatc tccctccctt ttcttctctc tgtggtggag    2640
aaccacagct gcagagtagg cagctgcctc caggatgagt tacttgaaat ttgccttgag    2700
tgtgttacct cctttccaag ctcctcgtga taatgcagac ttcctggagt acaaacacag    2760
gatttgtaat tccttactgt aacggagttt agagccaggg ctgatgcttt ggtgtggcca    2820
gcactctgaa actgagaaat gttcagaatg tacggaaaga tgatcagcta ttttcaacat    2880
aactgaaggc atatgctggc ccataaacac cctgtaggtt cttgatattt ataataaaat    2940
tggtgttttg taaaaaaaaa aaaaaaaaaa aaaa                                2974

<210> 207
<211> 5679
<212> DNA
<213> Homo sapiens

<400> 207
gcccgccctg gccgagcgta gctggcggac cagagccggt agcgaggttg ggagagacgg      60
agcggacctc agcgctgaag cagaagtccc cggagctgcg gtctccccgc cgcggctgag     120
ccatgcggct ccctgacctg agaccctgga cctccctgct gctggtggac gcggctttac     180
tgtggctgct tcagggccct ctggggactt tgcttcctca agggctgcca ggactatggc     240
tggaggggac cctgcggctg ggagggctgt gggggctgct aaagctaaga gggctgctgg     300
gatttgtggg gacactgctg ctcccgctct gtctggccac ccccctgact gtctccctga     360
gagccctggt cgcgggggcc tcacgtgctc ccccagccag agtcgcttca gccccttgga     420
gctggctgct ggtggggtac ggggctgcgg ggctcagctg gtcactgtgg gctgttctga     480
gccctcctgg agcccaggag aaggagcagg accaggtgaa caacaaagtc ttgatgtgga     540
ggctgctgaa gctctccagg ccggacctgc ctctcctcgt tgccgccttc ttcttccttg     600
tccttgctgt tttgggtgag acattaatcc ctcactattc tggtcgtgtg attgacatcc     660
tgggaggtga ttttgacccc catgcctttg ccagtgccat cttcttcatg tgcctcttct     720
cctttggcag ctcactgtct gcaggctgcc gaggaggctg cttcacctac accatgtctc     780
gaatcaactt gcggatccgg gagcagcttt tctcctccct gctgcgccag gacctcggtt     840
tcttccagga gactaagaca ggggagctga actcacggct gagctcggat accaccctga     900
tgagtaactg gcttccttta aatgccaatg tgctcttgcg aagcctggtg aaagtggtgg     960
ggctgtatgg cttcatgctc agcatatcgc ctcgactcac cctcctttct ctgctgcaca    1020
tgcccttcac aatagcagcg gagaaggtgt acaacacccg ccatcaggaa gtgcttcggg    1080
agatccagga tgcagtggcc agggcggggc aggtggtgcg ggaagccgtt ggagggctgc    1140
agaccgttcg cagttttggg gccgaggagc atgaagtctg tcgctataaa gaggcccttg    1200
aacaatgtcg gcagctgtat tggcggagag acctggaacg cgccttgtac ctgctcgtaa    1260
ggagggtgct gcacttgggg gtgcagatgc tgatgctgag ctgtgggctg cagcagatgc    1320
aggatgggga gctcacccag ggcagcctgc tttcctttat gatctaccag gagagcgtgg    1380
ggagctatgt gcagaccctg gtatacatat atggggatat gctcagcaac gtgggagctg    1440
cagagaaggt tttctcctac atggaccgac agccaaatct gccttcacct ggcacgcttg    1500
cccccaccac tctgcagggg gttgtgaaat tccaagacgt ctcctttgca tatcccaatc    1560
gccctgacag gcctgtgctc aaggggctga cgtttaccct acgtcctggt gaggtgacgg    1620
cgctggtggg acccaatggg tctgggaaga gcacagtggc tgccctgctg cagaatctgt    1680
accagcccac agggggacag gtgctgctgg atgaaaagcc catctcacag tatgaacact    1740
gctacctgca cagccaggtg gtttcagttg ggcaggagcc tgtgctgttc tccggttctg    1800
tgaggaacaa cattgcttat gggctgcaga gctgcgaaga tgataaggtg atggcggctg    1860
cccaggctgc ccacgcagat gacttcatcc aggaaatgga gcatggaata tacacagatg    1920
taggggagaa gggaagccag ctggctgcgg gacagaaaca acgtctggcc attgcccggg    1980
cccttgtacg agacccgcgg gtcctcatcc tggatgaggc tactagtgcc ctagatgtgc    2040
agtgcgagca ggccctgcag gactggaatt cccgtgggga tcgcacagtg ctggtgattg    2100
ctcacaggct gcaggcagtt cagcgcgccc accagatcct ggtgctccag gagggcaagc    2160
tgcagaagct tgcccagctc caggagggac aggacctcta ttcccgcctg gttcagcagc    2220
ggctgatgga ctgaggcccc agggatactg ggccctcttc tcaggggcgt ctccaggacc    2280
cagagctgtt cctgctttga gtttccctag agctgtgcgg ccagatagct gttcctgagt    2340
tgcaggcacg atggagattt ggacactgtg tgcttttggt ggggtagaga ggtggggtgg    2400
ggtggggtgg gggctgtctg tgtccaggaa acttaattcc ctggtgacta gagctttgcc    2460
tggtgatgag gagtattttg tggcataata catatatttt aaaatatttt ccttcttaca    2520
tgaactgtat acattcatat agaaaattta gacaatataa aaaagtacaa agaagaaaag    2580
taaaagtacc cattgtttca cttcctggag ataaccatag ttgctatttt gctgcctgtc    2640
ccatcagtcg tttatctgtt gtttgagata gaaattaacc aaaaatgaca taaatattca    2700
tgagattgcc ttcctatatc cttccttgtt cctaccagtg tctgctattt tgaagaagct    2760
agggtctgga gggacagaga acagttccct gattaacagt attaatagcg acattggtaa    2820
cagctaccat ttatagagtt ttaatgggag taggagctat gctaagtgtt tttcatgtat    2880
tatcgttttt aatcattatc cccaacccta tgaggttggt tattatcccc attttacaga    2940
tgaggaaact gaagctcaaa gaggctcaat gactttccca aggtggtcgt agtggtggag    3000
ttggagtttg aacacaggcc tgaccctaga gtccacaccc tgacccaatc aattatattg    3060
catcttgggt ccataaaccc taatccataa tcccatcaag aaaagctctg ctgctcttag    3120
ctctaaataa ttcagaatct attctcttct ctccagtccc gttgttatag tcttcactca    3180
tagacttaag atgatcccat caccagagag gtttctctac cattagcttc cctcttccgg    3240
ccattcttca caaagtcatt tttctaaatt ctgtgtcaca tacgatgatg gcatttctgg    3300
aaattccttc aggtgctctc aagccctgct gcagagatcc ttttcagagc acacactgtt    3360
ccagcccatc tgtctcaccc tctcctgttg tatccagctc cacgacaaac ttctgccttc    3420
cccaacacct ttgtgccttt gcatatggtg ttttcttgcc cattttctgc tcgactcgcc    3480
cctgattttc aagttcaaga cttaactcag ggttcaggtc ttccaggagg ccttacttat    3540
gtcgtcagtc tggggaactc tccatgtgct tctatcactg tgcggttacc tctttcacag    3600
cccttttaaa gttctatctt ccctttccca ccttttttga ccttccacta gaccatgagc    3660
acctgggcgg aaagccatat atcttattaa gctttatatc tgctacctgg ccgagggcct    3720
aattcatagt ggagaataaa tagtcaattg aataaatgaa taaatatctc caccatcgta    3780
ctaatcttaa tcctccctgc ccactcccac cactgaaaat gcaacattgt acacatcact    3840
ggttgttggg agggacttac cttggaaagt tgctattcta ggaaagagaa accttcatat    3900
tcctggaaac agcaggtagt ttccagtgct ggcaatgaat tccccagaac tgctgttttg    3960
gattttttct tgcctggcag ctgttgggag cagggtgcag tgaggatggg gtgagagtgg    4020
gcagtttctt gtgcagattt gcctttcttt catcctgggg ctgacttgca gctccacacc    4080
catccatctc tcaaatttca cagagggtaa aataggcatt tggagagaaa gaactctggc    4140
ctgattcctt tctctcccac aaatgtcctt tattcataaa acaggaataa taattcctgt    4200
atctcccaac tacatggaag ctgcagccct cacagaagaa gatgatctga gaaattcttt    4260
gatttcctca gtacagttat acccatgcat cataatactt taagcctgga aggcatctta    4320
aaaataatgc aacagtcaaa cctaatttta cagagaaact gacatgaaat cacgcagcta    4380
atcatgataa agctgggtgg aaaacttatc ttgatgggca gtacaggaag atgcagtaga    4440
ccttaagatg tcctgaaagt ttcttatctc aggggaaact cccaggtagg ctttatgtca    4500
gggacacaga aaaatgctcc ctgaaagtca aaatattcgg gctagacaga caaattcctg    4560
taagtgtggt ttgtctggga accacagatg tcactaatcc tggtttgctc cagagttctt    4620
tttgttcact cctacccccc atcaccattt gattgatctc cttaccctgt aatttcccct    4680
tcttgtcgct tacctgcagt atctttccca cccaggcatg ccttattctt tctaaaggaa    4740
agtatgaatg gagaggggaa agcttgggaa actgatagat ttccttggat gccaaaacac    4800
ctccatagcc tgtctgcccg gccctatgtg gaaacagcat tgagtttcaa gtcctttatg    4860
cctccaccca gggatagcca cttgtaatcc acatggcaat tgtgaaacaa gcaggaaatg    4920
cgtaattgtc agaattttgt ggggaaagga ctagggaata aggaaaacaa agatcttcct    4980
tgtgttttag agctgtcagc tagaggagca cctgcttgag tctgatgcca tctaatggtc    5040
ccagaagaaa ctgggttttg aacctagagt tccatggact cttaggaatt agactactac    5100
tactactaag cattcactgg tgcttactat gtgctattgc tgtgccaagt atctgaaacc    5160
tgtcttctta ccttattttt caagataatt ctatgtggca ggtattacta tctcaattct    5220
aagagtgaga aaatggagtt ttagaaacat ttactaactt gcctgggtca catagctaag    5280
gaagaggtgg acttgcccag ctttgcataa aactcctcaa aagagttgcc tatactccct    5340
gactccactt atcttcctac tatcctcttt ttaaaatata ttatttattt atttaaataa    5400
gcaatatatg aatgtggttt gaaattcaaa agacacaaag aagtatacag aggaaagcct    5460
cactctcaat ccttctcaag gtttgctaat tcctcttgca taggcaatcc gttcttccag    5520
ctttgtgttt atctttccag agaagtttac tgtgtattaa gcaaatatgt atatctttat    5580
tcttgctcag tattttcgca aacagcagct gtctaagttc actgttctga actttatttt    5640
ttaaattaaa aatatatggc tatgtagtat tctatttta                           5679



<210> 208
<211> 3417
<212> DNA
<213> Homo sapiens

<400> 208
gtcactgagg ccccgccccg tccatcagcc tgtctcaacg cacgccagtc tcagctccga      60
ccttgcagcg gcgcagcgcg ggtgggaggc ggggaggagc agcgggaaga gcggagcgag     120
gaccgcgtcc ggcgcagtct tcaatgagca gcgcggaaac tgcaccccag acccgagcct     180
gctgcgcgcc ccctcccaga gctcacctgg tgccaggtaa caggcctggc ctcgccctgt     240
ggatgatgat ggccttgccc ccgtgagcta caacctggcc ttcagcaccc gcccacctcc     300
aaccagcagg atgcggctgt ggaaggcggt ggtggtgact ttggccttca tgagtgtgga     360
catctgcgtg accacggcca tctatgtctt cagccacctg gaccgcagcc tcctggagga     420
catccgccac ttcaacatct ttgactcggt gctggatctc tgggcagcct gcctgtaccg     480
cagctgcctg ctgctgggag ccaccattgg tgtggccaag aacagtgcgc tggggccccg     540
gcggctgcgg gcctcgtggc tggtcatcac cctcgtgtgc ctcttcgtgg gcatctatgc     600
catggtgaag ctgctgctct tctcagaggt gcgcaggccc atccgggacc cctggttttg     660
ggccctgttc gtgtggacgt acatttcact cggcgcatcc ttcctgctct ggtggctgct     720
gtccaccgtg cggccaggca cccaggccct ggagccaggg gcggccaccg aggctgaggg     780
cttccctggg agcggccggc caccgcccga gcaggcgtct ggggccacgc tgcagaagct     840
gctctcctac accaagcccg acgtggcctt cctcgtggcc gcctccttct tcctcatcgt     900
ggcagctctg ggagagacct tcctgcccta ctacacgggc cgcgccattg atggcatcgt     960
catccagaaa agcatggatc agttcagcac ggctgtcgtc atcgtgtgcc tgctggccat    1020
tggcagctca tttgccgcag gtattcgggg cggcattttt accctcatat ttgccagact    1080
gaacattcgc cttcgaaact gtctcttccg ctcactggtg tcccaggaga caagcttctt    1140
tgatgagaac cgcacagggg acctcatctc ccgcctgacc tcggacacca ccatggtcag    1200
cgacctggtc tcccagaaca tcaatgtctt cctgcggaac acagtcaagg tcacgggcgt    1260
ggtggtcttc atgttcagcc tctcatggca gctctccttg gtcaccttca tgggcttccc    1320
catcatcatg atggtgtcca acatctacgg caagtactac aagaggctct ccaaagaggt    1380
ccagaatgcc ctggccagag cgagcaacac ggcggaggag accatcagtg ccatgaagac    1440
tgtccggagc ttcgccaatg aggaggagga ggcagaggtg tacctgcgga agctgcagca    1500
ggtgtacaag ctgaacagga aggaggcagc tgcctacatg tactacgtct ggggcagcgg    1560
gtccgtgggc tccgtctaca gtggcctgat gcagggagtg ggggctgctg agaaggtgtt    1620
cgagttcatc gaccggcagc cgaccatggt gcacgatggc agcttggccc ccgaccacct    1680
ggagggccgg gtggactttg agaatgtgac cttcacctac cgcactcggc cccacaccca    1740
ggtcctgcag aatgtctcct tcagcctgtc ccccggcaag gtgacggccc tggtggggcc    1800
ctcgggcagt gggaagagct cctgtgtcaa catcctggag aacttctacc ccctggaggg    1860
gggccgggtg ctgctggacg gcaagcccat cagcgcctac gaccacaagt acttgcaccg    1920
tgtgatctcc ctggtgagcc aggagcccgt gctgttcgcc cgctccatca cggataacat    1980
ctcctacggc ctgcccactg tgcctttcga gatggtggtg gaggccgcac agaaggccaa    2040
tgcccacggc ttcatcatgg aactccagga cggctacagc acagagacag gggagaaggg    2100
cgcccagctg tcaggtggcc agaagcagcg ggtggccatg gcccgggctc tggtgcggaa    2160
ccccccagtc ctcatcctgg atgaagccac cagcgctttg gatgccgaga gcgagtatct    2220
gatccagcag gccatccatg gcaacctgca gaagcacacg gtactcatca tcgcgcaccg    2280
gctgagcacc gtggagcacg cgcacctcat tgtggtgctg gacaagggcc gcgtagtgca    2340
gcagggcacc caccagcagc tgctggccca gggcggcctc tacgccaagc tggtgcagcg    2400
gcagatgctg gggcttcagc ccgccgcaga cttcacagct ggccacaacg agcctgtagc    2460
caacggcagt cacaaggcct gatggggggc ccctgcttct cccggtgggg cagaggaccc    2520
ggtgcctgcc tggcagatgt gcccacggag gcccccagct gccctccgag cccaggcctg    2580
cagcactgaa agacgacctg ccatgtccca tggatcaccg cttcctgcat cttgcccctg    2640
gtccctgccc cattcccagg gcactcctta cccctgctgc cctgagccaa cgccttcacg    2700
gacctcccta gcctcctaag caaaggtaga gctgcctttt taaacctagg tcttaccagg    2760
gtttttactg tttggtttga ggcaccccag tcaactccta gatttcaaaa acctttttct    2820
aattgggagt aatggcgggc actttcacca agatgttcta gaaacttctg agccaggagt    2880
gaatggccct tccttagtag cctgggggat gtccagagac taggcctctc ccctttaccc    2940
ctccagagaa ggggcttccc tgtcccggag ggagacacgg ggaacgggat tttccgtctc    3000
tccctcttgc cagctctgtg agtctggcca gggcgggtag ggagcgtgga gggcatctgt    3060
ctgccatcgc ccgctgccaa tctaagccag tctcactgtg aaccacacga aacctcaact    3120
gggggagtga ggggctggcc aggtctggag gggcctcagg ggtgccccca gcccggcacc    3180
cagcgctttc gcccctcgtc cacccacccc tggctggcag cctccctccc cacacccgcc    3240
cctgtgctct gctgtctgga ggccacgtgg atgttcatga gatgcattct cttctgtctt    3300
tggtggatgg gatggtggca aagcccagga tctggctttg ccagaggttg caacatgttg    3360
agagaacccg gtcaataaag tgtactacct cttaccccta aaaaaaaaaa aaaaaaa       3417

<210> 209
<211> 2475
<212> DNA
<213> Artificial Sequence

<220> 
<223> Tap1 sequence with optimized Kosak and NH2 tag

<400> 209
gccaccatgg gcaagcccat ccccaacccc ctgctgggcc tggacagcac cgctgagctt      60
ctcgccagcg caggatcagc ctgttcctgg gactttccga gagccccgcc ctcgttccct     120
cccccagccg ccagtagggg aggactcggc ggtacccgga gcttcaggcc ccaccggggc     180
gcggagagtc ccaggcccgg ccgggaccgg gacggcgtcc gagtgccaat ggctagctct     240
aggtgtcccg ctccccgcgg gtgccgctgc ctccccggag cttctctcgc atggctgggg     300
acagtactgc tacttctcgc cgactgggtg ctgctccgga ccgcgctgcc ccgcatattc     360
tccctgctgg tgcccaccgc gctgccactg ctccgggtct gggcggtggg cctgagccgc     420
tgggccgtgc tctggctggg ggcctgcggg gtcctcaggg caacggttgg ctccaagagc     480
gaaaacgcag gtgcccaggg ctggctggct gctttgaagc cattagctgc ggcactgggc     540
ttggccctgc cgggacttgc cttgttccga gagctgatct catggggagc ccccgggtcc     600
gcggatagca ccaggctact gcactgggga agtcacccta ccgccttcgt tgtcagttat     660
gcagcggcac tgcccgcagc agccctgtgg cacaaactcg ggagcctctg ggtgcccggc     720
ggtcagggcg gctctggaaa ccctgtgcgt cggcttctag gctgcctggg ctcggagacg     780
cgccgcctct cgctgttcct ggtcctggtg gtcctctcct ctcttgggga gatggccatt     840
ccattcttta cgggccgcct cactgactgg attctacaag atggctcagc cgataccttc     900
actcgaaact taactctcat gtccattctc accatagcca gtgcagtgct ggagttcgtg     960
ggtgacggga tctataacaa caccatgggc cacgtgcaca gccacttgca gggagaggtg    1020
tttggggctg tcctgcgcca ggagacggag tttttccaac agaaccagac aggtaacatc    1080
atgtctcggg taacagagga cacgtccacc ctgagtgatt ctctgagtga gaatctgagc    1140
ttatttctgt ggtacctggt gcgaggccta tgtctcttgg ggatcatgct ctggggatca    1200
gtgtccctca ccatggtcac cctgatcacc ctgcctctgc ttttccttct gcccaagaag    1260
gtgggaaaat ggtaccagtt gctggaagtg caggtgcggg aatctctggc aaagtccagc    1320
caggtggcca ttgaggctct gtcggccatg cctacagttc gaagctttgc caacgaggag    1380
ggcgaagccc agaagtttag ggaaaagctg caagaaataa agacactcaa ccagaaggag    1440
gctgtggcct atgcagtcaa ctcctggacc actagtattt caggtatgct gctgaaagtg    1500
ggaatcctct acattggtgg gcagctggtg accagtgggg ctgtaagcag tgggaacctt    1560
gtcacatttg ttctctacca gatgcagttc acccaggctg tggaggtact gctctccatc    1620
taccccagag tacagaaggc tgtgggctcc tcagagaaaa tatttgagta cctggaccgc    1680
acccctcgct gcccacccag tggtctgttg actcccttac acttggaggg ccttgtccag    1740
ttccaagatg tctcctttgc ctacccaaac cgcccagatg tcttagtgct acaggggctg    1800
acattcaccc tacgccctgg cgaggtgacg gcgctggtgg gacccaatgg gtctgggaag    1860
agcacagtgg ctgccctgct gcagaatctg taccagccca ccgggggaca gctgctgttg    1920
gatgggaagc cccttcccca atatgagcac cgctacctgc acaggcaggt ggctgcagtg    1980
ggacaagagc cacaggtatt tggaagaagt cttcaagaaa atattgccta tggcctgacc    2040
cagaagccaa ctatggagga aatcacagct gctgcagtaa agtctggggc ccatagtttc    2100
atctctggac tccctcaggg ctatgacaca gaggtagacg aggctgggag ccagctgtca    2160
gggggtcagc gacaggcagt ggcgttggcc cgagcattga tccggaaacc gtgtgtactt    2220
atcctggatg atgccaccag tgccctggat gcaaacagcc agttacaggt ggagcagctc    2280
ctgtacgaaa gccctgagcg gtactcccgc tcagtgcttc tcatcaccca gcacctcagc    2340
ctggtggagc aggctgacca catcctcttt ctggaaggag gcgctatccg ggagggggga    2400
acccaccagc agctcatgga gaaaaagggg tgctactggg ccatggtgca ggctcctgca    2460
gatgctccag aatga                                                     2475

<210> 210
<211> 2136
<212> DNA
<213> Artificial Sequence

<220> 
<223> hTap2 with NH2 tag and optimized Kosak

<400> 210
gccaccatga ccgacttcta cctgaagcgg ctccctgacc tgagaccctg gacctccctg      60
ctgctggtgg acgcggcttt actgtggctg cttcagggcc ctctggggac tttgcttcct     120
caagggctgc caggactatg gctggagggg accctgcggc tgggagggct gtgggggctg     180
ctaaagctaa gagggctgct gggatttgtg gggacactgc tgctcccgct ctgtctggcc     240
acccccctga ctgtctccct gagagccctg gtcgcggggg cctcacgtgc tcccccagcc     300
agagtcgctt cagccccttg gagctggctg ctggtggggt acggggctgc ggggctcagc     360
tggtcactgt gggctgttct gagccctcct ggagcccagg agaaggagca ggaccaggtg     420
aacaacaaag tcttgatgtg gaggctgctg aagctctcca ggccggacct gcctctcctc     480
gttgccgcct tcttcttcct tgtccttgct gttttgggtg agacattaat ccctcactat     540
tctggtcgtg tgattgacat cctgggaggt gattttgacc cccatgcctt tgccagtgcc     600
atcttcttca tgtgcctctt ctcctttggc agctcactgt ctgcaggctg ccgaggaggc     660
tgcttcacct acaccatgtc tcgaatcaac ttgcggatcc gggagcagct tttctcctcc     720
ctgctgcgcc aggacctcgg tttcttccag gagactaaga caggggagct gaactcacgg     780
ctgagctcgg ataccaccct gatgagtaac tggcttcctt taaatgccaa tgtgctcttg     840
cgaagcctgg tgaaagtggt ggggctgtat ggcttcatgc tcagcatatc gcctcgactc     900
accctccttt ctctgctgca catgcccttc acaatagcag cggagaaggt gtacaacacc     960
cgccatcagg aagtgcttcg ggagatccag gatgcagtgg ccagggcggg gcaggtggtg    1020
cgggaagccg ttggagggct gcagaccgtt cgcagttttg gggccgagga gcatgaagtc    1080
tgtcgctata aagaggccct tgaacaatgt cggcagctgt attggcggag agacctggaa    1140
cgcgccttgt acctgctcgt aaggagggtg ctgcacttgg gggtgcagat gctgatgctg    1200
agctgtgggc tgcagcagat gcaggatggg gagctcaccc agggcagcct gctttccttt    1260
atgatctacc aggagagcgt ggggagctat gtgcagaccc tggtatacat atatggggat    1320
atgctcagca acgtgggagc tgcagagaag gttttctcct acatggaccg acagccaaat    1380
ctgccttcac ctggcacgct tgcccccacc actctgcagg gggttgtgaa attccaagac    1440
gtctcctttg catatcccaa tcgccctgac aggcctgtgc tcaaggggct gacgtttacc    1500
ctacgtcctg gtgaggtgac ggcgctggtg ggacccaatg ggtctgggaa gagcacagtg    1560
gctgccctgc tgcagaatct gtaccagccc acagggggac aggtgctgct ggatgaaaag    1620
cccatctcac agtatgaaca ctgctacctg cacagccagg tggtttcagt tgggcaggag    1680
cctgtgctgt tctccggttc tgtgaggaac aacattgctt atgggctgca gagctgcgaa    1740
gatgataagg tgatggcggc tgcccaggct gcccacgcag atgacttcat ccaggaaatg    1800
gagcatggaa tatacacaga tgtaggggag aagggaagcc agctggctgc gggacagaaa    1860
caacgtctgg ccattgcccg ggcccttgta cgagacccgc gggtcctcat cctggatgag    1920
gctactagtg ccctagatgt gcagtgcgag caggccctgc aggactggaa ttcccgtggg    1980
gatcgcacag tgctggtgat tgctcacagg ctgcaggcag ttcagcgcgc ccaccagatc    2040
ctggtgctcc aggagggcaa gctgcagaag cttgcccagc tccaggaggg acaggacctc    2100
tattcccgcc tggttcagca gcggctgatg gactga                              2136
