                         SEQUENCE LISTING

<110>  Avalanche Biotechnologies, Inc.
       Chalberg, Thomas W. Jr.
       Neitz, Jay
       Neitz, Maureen
 
<120>  COMPOSITIONS AND METHODS FOR ENHANCED GENE EXPRESSION IN CONE 
       CELLS

<130>  AVBI-005/02WO

<150>  US 61/954,330
<151>  2014-03-17

<150>  US 62/127,185
<151>  2015-03-02

<160>  103   

<170>  PatentIn version 3.5

<210>  1
<211>  494
<212>  DNA
<213>  Homo sapiens

<400>  1
ggatccggtt ccaggcctcg gccctaaata gtctccctgg gctttcaaga gaaccacatg       60

agaaaggagg attcgggctc tgagcagttt caccacccac cccccagtct gcaaatcctg      120

acccgtgggt ccacctgccc caaaggcgga cgcaggacag tagaagggaa cagagaacac      180

ataaacacag agagggccac agcggctccc acagtcaccg ccaccttcct ggcggggatg      240

ggtggggcgt ctgagtttgg ttcccagcaa atccctctga gccgcccttg cgggctcgcc      300

tcaggagcag gggagcaaga ggtgggagga ggaggtctaa gtcccaggcc caattaagag      360

atcaggtagt gtagggtttg ggagctttta aggtgaagag gcccgggctg atcccacagg      420

ccagtataaa gcgccgtgac cctcaggtga tgcgccaggg ccggctgccg tcggggacag      480

ggctttccat agcc                                                        494


<210>  2
<211>  494
<212>  DNA
<213>  Homo sapiens

<400>  2
ttatttagta gaaacggggt ttcaccatgt tagtcaggct ggtcgggaac tcctgacctc       60

aggagatcta cccgccttgg cctcccaaag tgctgggatt acaggcgtgt gccactgtgc      120

ccagccactt ttttttagac agagtcttgg tctgttgccc aggctagagt tcagtggcgc      180

catctcagct cactgcaacc tccgcctccc agattcaagc gattctcctg cctcgacctc      240

ccagtagctg ggattacagg tttccagcaa atccctctga gccgcccccg ggggctcgcc      300

tcaggagcaa ggaagcaagg ggtgggagga ggaggtctaa gtcccaggcc caattaagag      360

atcagatggt gtaggatttg ggagctttta aggtgaagag gcccgggctg atcccactgg      420

ccggtataaa gcaccgtgac cctcaggtga cgcaccaggg ccggctgccg tcggggacag      480

ggctttccat agcc                                                        494


<210>  3
<211>  568
<212>  DNA
<213>  Homo sapiens

<400>  3
ctaggcattg tcaagttgcc taagtcctgt tccatcaagg ctgtttactg atgtgcttcc       60

agggcactcc ccactcccag ccctttcctg cagcccaggg ctggttccta gcctctcagc      120

agacttaaga tgggcacctt ccacaaaggg gcagatgagt tgaggaaaac ttaactgata      180

cagttgtgcc agaagccaaa ataagaggcg tgccctttct atagccccat taaaagaaca      240

aaaaagtgga agcatcttca gtgaatatgg gtcagcacct cccagacctc agggagtcca      300

cttctgttca tcccagcacc cagcattgca tatccagatt atttgagccc aatctcttat      360

cctctgaaga acacaatcgg ctttggggcc acaaaaggtt taggtagtgg tttagggatt      420

tctaatccca aactttgtcc ttgggaggtt taggattagt attgatcatt cacagagccc      480

aagtgttttt agaggagggg ttttgtgggg tgggaggatc acctataaga ggactcagag      540

gggggtgtgg ggcatccatg agaaaaat                                         568


<210>  4
<211>  1555
<212>  DNA
<213>  Homo sapiens

<400>  4
ccagggtgag attatgaggc tgagctgaga atatcaagac tgtaccgagt agggggcctt       60

ggcaagtgtg gagagcccgg cagctggggc agagggcgga gtacggtgtg cgtttacgga      120

cctcttcaaa cgaggtagga aggtcagaag tcaaaaaggg aacaaatgat gtttaaccac      180

acaaaaatga aaatccaatg gttggatatc cattccaaat acacaaaggc aacggataag      240

tgatccgggc caggcacaga aggccatgca cccgtaggat tgcactcaga gctcccaaat      300

gcataggaat agaagggtgg gtgcaggagg ctgaggggtg gggaaagggc atgggtgttt      360

catgaggaca gagcttccgt ttcatgcaat gaaaagagtt tggagacgga tggtggtgac      420

tggactatac acttacacac ggtagcgatg gtacactttg tattatgtat attttaccac      480

gatcttttta aagtgtcaaa ggcaaatggc caaatggttc cttgtcctat agctgtagca      540

gccatcggct gttagtgaca aagcccctga gtcaagatga cagcagcccc cataactcct      600

aatcggctct cccgcgtgga gtcatttagg agtagtcgca ttagagacaa gtccaacatc      660

taatcttcca ccctggccag ggccccagct ggcagcgagg gtgggagact ccgggcagag      720

cagagggcgc tgacattggg gcccggcctg gcttgggtcc ctctggcctt tccccagggg      780

ccctctttcc ttggggcttt cttgggccgc cactgctccc gctcctctcc ccccatccca      840

ccccctcacc ccctcgttct tcatatcctt ctctagtgct ccctccactt tcatccaccc      900

ttctgcaaga gtgtgggacc acaaatgagt tttcacctgg cctggggaca cacgtgcccc      960

cacaggtgct gagtgacttt ctaggacagt aatctgcttt aggctaaaat gggacttgat     1020

cttctgttag ccctaatcat caattagcag agccggtgaa ggtgcagaac ctaccgcctt     1080

tccaggcctc ctcccacctc tgccacctcc actctccttc ctgggatgtg ggggctggca     1140

cacgtgtggc ccagggcatt ggtgggattg cactgagctg ggtcattagc gtaatcctgg     1200

acaagggcag acagggcgag cggagggcca gctccggggc tcaggcaagg ctgggggctt     1260

cccccagaca ccccactcct cctctgctgg acccccactt catagggcac ttcgtgttct     1320

caaagggctt ccaaatagca tggtggcctt ggatgcccag ggaagcctca gagttgctta     1380

tctccctcta gacagaaggg gaatctcggt caagagggag aggtcgccct gttcaaggcc     1440

acccagccag ctcatggcgg taatgggaca aggctggcca gccatcccac cctcagaagg     1500

gacccggtgg ggcaggtgat ctcagaggag gctcacttct gggtctcaca ttctt          1555


<210>  5
<211>  189
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Modified SV40 intron

<400>  5
gatccggtac tcgaggaact gaaaaaccag aaagttaact ggtaagttta gtctttttgt       60

cttttatttc aggtcccgga tccggtggtg gtgcaaatca aagaactgct cctcagtgga      120

tgttgccttt acttctaggc ctgtacggaa gtgttacttc tgctctaaaa gctgcggaat      180

tgtacccgc                                                              189


<210>  6
<211>  1114
<212>  DNA
<213>  Homo sapiens

<400>  6
atgagaaaaa tgtcggagga agagttttat ctgttcaaaa atatctcttc agtggggccg       60

tgggatgggc ctcagtacca cattgcccct gtctgggcct tctacctcca ggcagctttc      120

atgggcactg tcttccttat agggttccca ctcaatgcca tggtgctggt ggccacactg      180

cgctacaaaa agttgcggca gcccctcaac tacattctgg tcaacgtgtc cttcggaggc      240

ttcctcctct gcatcttctc tgtcttccct gtcttcgtcg ccagctgtaa cggatacttc      300

gtcttcggtc gccatgtttg tgctttggag ggcttcctgg gcactgtagc aggtctggtt      360

acaggatggt cactggcctt cctggccttt gagcgctaca ttgtcatctg taagcccttc      420

ggcaacttcc gcttcagctc caagcatgca ctgacggtgg tcctggctac ctggaccatt      480

ggtattggcg tctccatccc acccttcttt ggctggagcc ggttcatccc tgagggcctg      540

cagtgttcct gtggccctga ctggtacacc gtgggcacca aataccgcag cgagtcctat      600

acgtggttcc tcttcatctt ctgcttcatt gtgcctctct ccctcatctg cttctcctac      660

actcagctgc tgagggccct gaaagctgtt gcagctcagc agcaggagtc agctacgacc      720

cagaaggctg aacgggaggt gagccgcatg gtggttgtga tggtaggatc cttctgtgtc      780

tgctacgtgc cctacgcggc cttcgccatg tacatggtca acaaccgtaa ccatgggctg      840

gacttacggc ttgtcaccat tccttcattc ttctccaaga gtgcttgcat ctacaatccc      900

atcatctact gcttcatgaa taagcagttc caagcttgca tcatgaagat ggtgtgtggg      960

aaggccatga cagatgaatc cgacacatgc agctcccaga aaacagaagt ttctactgtc     1020

tcgtctaccc aagttggccc caactgagga cccaatattg gcctgtttgc aacagctaga     1080

attaaatttt acttttaaaa aaaaaaaaaa aaaa                                 1114


<210>  7
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Arg Lys Met Ser Glu Glu Glu Phe Tyr Leu Phe Lys Asn Ile Ser 
1               5                   10                  15      


Ser Val Gly Pro Trp Asp Gly Pro Gln Tyr His Ile Ala Pro Val Trp 
            20                  25                  30          


Ala Phe Tyr Leu Gln Ala Ala Phe Met Gly Thr Val Phe Leu Ile Gly 
        35                  40                  45              


Phe Pro Leu Asn Ala Met Val Leu Val Ala Thr Leu Arg Tyr Lys Lys 
    50                  55                  60                  


Leu Arg Gln Pro Leu Asn Tyr Ile Leu Val Asn Val Ser Phe Gly Gly 
65                  70                  75                  80  


Phe Leu Leu Cys Ile Phe Ser Val Phe Pro Val Phe Val Ala Ser Cys 
                85                  90                  95      


Asn Gly Tyr Phe Val Phe Gly Arg His Val Cys Ala Leu Glu Gly Phe 
            100                 105                 110         


Leu Gly Thr Val Ala Gly Leu Val Thr Gly Trp Ser Leu Ala Phe Leu 
        115                 120                 125             


Ala Phe Glu Arg Tyr Ile Val Ile Cys Lys Pro Phe Gly Asn Phe Arg 
    130                 135                 140                 


Phe Ser Ser Lys His Ala Leu Thr Val Val Leu Ala Thr Trp Thr Ile 
145                 150                 155                 160 


Gly Ile Gly Val Ser Ile Pro Pro Phe Phe Gly Trp Ser Arg Phe Ile 
                165                 170                 175     


Pro Glu Gly Leu Gln Cys Ser Cys Gly Pro Asp Trp Tyr Thr Val Gly 
            180                 185                 190         


Thr Lys Tyr Arg Ser Glu Ser Tyr Thr Trp Phe Leu Phe Ile Phe Cys 
        195                 200                 205             


Phe Ile Val Pro Leu Ser Leu Ile Cys Phe Ser Tyr Thr Gln Leu Leu 
    210                 215                 220                 


Arg Ala Leu Lys Ala Val Ala Ala Gln Gln Gln Glu Ser Ala Thr Thr 
225                 230                 235                 240 


Gln Lys Ala Glu Arg Glu Val Ser Arg Met Val Val Val Met Val Gly 
                245                 250                 255     


Ser Phe Cys Val Cys Tyr Val Pro Tyr Ala Ala Phe Ala Met Tyr Met 
            260                 265                 270         


Val Asn Asn Arg Asn His Gly Leu Asp Leu Arg Leu Val Thr Ile Pro 
        275                 280                 285             


Ser Phe Phe Ser Lys Ser Ala Cys Ile Tyr Asn Pro Ile Ile Tyr Cys 
    290                 295                 300                 


Phe Met Asn Lys Gln Phe Gln Ala Cys Ile Met Lys Met Val Cys Gly 
305                 310                 315                 320 


Lys Ala Met Thr Asp Glu Ser Asp Thr Cys Ser Ser Gln Lys Thr Glu 
                325                 330                 335     


Val Ser Thr Val Ser Ser Thr Gln Val Gly Pro Asn 
            340                 345             


<210>  8
<211>  1998
<212>  DNA
<213>  Homo sapiens

<400>  8
cccactggcc ggtataaagc accgtgaccc tcaggtgacg caccagggcc ggctgccgtc       60

ggggacaggg ctttccatag ccatggccca gcagtggagc ctccaaaggc tcgcaggccg      120

ccatccgcag gacagctatg aggacagcac ccagtccagc atcttcacct acaccaacag      180

caactccacc agaggcccct tcgaaggccc gaattaccac atcgctccca gatgggtgta      240

ccacctcacc agtgtctgga tgatctttgt ggtcattgca tccgtcttca caaatgggct      300

tgtgctggcg gccaccatga agttcaagaa gctgcgccac ccgctgaact ggatcctggt      360

gaacctggcg gtcgctgacc tggcagagac cgtcatcgcc agcactatca gcgttgtgaa      420

ccaggtctat ggctacttcg tgctgggcca ccctatgtgt gtcctggagg gctacaccgt      480

ctccctgtgt gggatcacag gtctctggtc tctggccatc atttcctggg agagatggat      540

ggtggtctgc aagccctttg gcaatgtgag atttgatgcc aagctggcca tcgtgggcat      600

tgccttctcc tggatctggg ctgctgtgtg gacagccccg cccatctttg gttggagcag      660

gtactggccc cacggcctga agacttcatg cggcccagac gtgttcagcg gcagctcgta      720

ccccggggtg cagtcttaca tgattgtcct catggtcacc tgctgcatca ccccactcag      780

catcatcgtg ctctgctacc tccaagtgtg gctggccatc cgagcggtgg caaagcagca      840

gaaagagtct gaatccaccc agaaggcaga gaaggaagtg acgcgcatgg tggtggtgat      900

ggtcctggca ttctgcttct gctggggacc atacgccttc ttcgcatgct ttgctgctgc      960

caaccctggc taccccttcc accctttgat ggctgccctg ccggccttct ttgccaaaag     1020

tgccactatc tacaaccccg ttatctatgt ctttatgaac cggcagtttc gaaactgcat     1080

cttgcagctt ttcgggaaga aggttgacga tggctctgaa ctctccagcg cctccaaaac     1140

ggaggtctca tctgtgtcct cggtatcgcc tgcatgaggt ctgcctccta cccatcccgc     1200

ccaccggggc tttggccacc tctcctttcc ccctccttct ccatccctgt aaaataaatg     1260

taatttatct ttgccaaaac caacaaagtc acagaggctt tcactgcagt gtgggaccac     1320

ctgagcctct gcgtgtgcag gcactgggtc tcgagagggt gcaaggggga taaagaggag     1380

agagcgcttc atagacttta agttttcccg agcctcatgt ctaccgatgg cgtgaaagga     1440

tcctggcaaa acagaagtgt gaggcaggtg ggcgtctata tccatttcac caggctggtg     1500

gttacataat cggcaagcaa gagctgtgga ggggcttgct ggatgccctc agcacccagg     1560

aggagggagg gagctagcaa gctaaggcag gtggccctcc tggcccctta aggtccatct     1620

gctggaggcc cagagtcctt ggagtacagt ctacacctgg aggggaccca ttcctgccag     1680

tctgtggcag ggatggcgcg ccacctctgc caggccagga ccccaagccc gatcagcatc     1740

agcatggtgc aggtgcacag gcgtgagctg atcagtgacg aggggcaggc acacaaggtg     1800

gagacaaaga ccaagaggac ggttgccagt gagaggcgcg gactcaggaa cttgaacaac     1860

atctgcgggg gacggctttg gaggtgctcc gctgcctcca gttgggtgac ttgctgtagc     1920

atctccagct tggatattcg gctcttgaag gtctccgtga tctcctgcag gagacgaaaa     1980

tgcacgcacc agaagtca                                                   1998


<210>  9
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Gln Gln Trp Ser Leu Gln Arg Leu Ala Gly Arg His Pro Gln 
1               5                   10                  15      


Asp Ser Tyr Glu Asp Ser Thr Gln Ser Ser Ile Phe Thr Tyr Thr Asn 
            20                  25                  30          


Ser Asn Ser Thr Arg Gly Pro Phe Glu Gly Pro Asn Tyr His Ile Ala 
        35                  40                  45              


Pro Arg Trp Val Tyr His Leu Thr Ser Val Trp Met Ile Phe Val Val 
    50                  55                  60                  


Ile Ala Ser Val Phe Thr Asn Gly Leu Val Leu Ala Ala Thr Met Lys 
65                  70                  75                  80  


Phe Lys Lys Leu Arg His Pro Leu Asn Trp Ile Leu Val Asn Leu Ala 
                85                  90                  95      


Val Ala Asp Leu Ala Glu Thr Val Ile Ala Ser Thr Ile Ser Val Val 
            100                 105                 110         


Asn Gln Val Tyr Gly Tyr Phe Val Leu Gly His Pro Met Cys Val Leu 
        115                 120                 125             


Glu Gly Tyr Thr Val Ser Leu Cys Gly Ile Thr Gly Leu Trp Ser Leu 
    130                 135                 140                 


Ala Ile Ile Ser Trp Glu Arg Trp Met Val Val Cys Lys Pro Phe Gly 
145                 150                 155                 160 


Asn Val Arg Phe Asp Ala Lys Leu Ala Ile Val Gly Ile Ala Phe Ser 
                165                 170                 175     


Trp Ile Trp Ala Ala Val Trp Thr Ala Pro Pro Ile Phe Gly Trp Ser 
            180                 185                 190         


Arg Tyr Trp Pro His Gly Leu Lys Thr Ser Cys Gly Pro Asp Val Phe 
        195                 200                 205             


Ser Gly Ser Ser Tyr Pro Gly Val Gln Ser Tyr Met Ile Val Leu Met 
    210                 215                 220                 


Val Thr Cys Cys Ile Thr Pro Leu Ser Ile Ile Val Leu Cys Tyr Leu 
225                 230                 235                 240 


Gln Val Trp Leu Ala Ile Arg Ala Val Ala Lys Gln Gln Lys Glu Ser 
                245                 250                 255     


Glu Ser Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Val Val 
            260                 265                 270         


Met Val Leu Ala Phe Cys Phe Cys Trp Gly Pro Tyr Ala Phe Phe Ala 
        275                 280                 285             


Cys Phe Ala Ala Ala Asn Pro Gly Tyr Pro Phe His Pro Leu Met Ala 
    290                 295                 300                 


Ala Leu Pro Ala Phe Phe Ala Lys Ser Ala Thr Ile Tyr Asn Pro Val 
305                 310                 315                 320 


Ile Tyr Val Phe Met Asn Arg Gln Phe Arg Asn Cys Ile Leu Gln Leu 
                325                 330                 335     


Phe Gly Lys Lys Val Asp Asp Gly Ser Glu Leu Ser Ser Ala Ser Lys 
            340                 345                 350         


Thr Glu Val Ser Ser Val Ser Ser Val Ser Pro Ala 
        355                 360                 


<210>  10
<211>  1234
<212>  DNA
<213>  Homo sapiens

<400>  10
cggctgccgt cggggacagg gctttccata gccatggccc agcagtggag cctccaaagg       60

ctcgcaggcc gccatccgca ggacagctat gaggacagca cccagtccag catcttcacc      120

tacaccaaca gcaactccac cagaggcccc ttcgaaggcc cgaattacca catcgctccc      180

agatgggtgt accacctcac cagtgtctgg atgatctttg tggtcactgc atccgtcttc      240

acaaatgggc ttgtgctggc ggccaccatg aagttcaaga agctgcgcca cccgctgaac      300

tggatcctgg tgaacctggc ggtcgctgac ctagcagaga ccgtcatcgc cagcactatc      360

agcattgtga accaggtctc tggctacttc gtgctgggcc accctatgtg tgtcctggag      420

ggctacaccg tctccctgtg tgggatcaca ggtctctggt ctctggccat catttcctgg      480

gagaggtggc tggtggtgtg caagcccttt ggcaatgtga gatttgatgc caagctggcc      540

atcgtgggca ttgccttctc ctggatctgg tctgctgtgt ggacagcccc gcccatcttt      600

ggttggagca ggtactggcc ccacggcctg aagacttcat gcggcccaga cgtgttcagc      660

ggcagctcgt accccggggt gcagtcttac atgattgtcc tcatggtcac ctgctgcatc      720

atcccactcg ctatcatcat gctctgctac ctccaagtgt ggctggccat ccgagcggtg      780

gcaaagcagc agaaagagtc tgaatccacc cagaaggcag agaaggaagt gacgcgcatg      840

gtggtggtga tgatctttgc gtactgcgtc tgctggggac cctacacctt cttcgcatgc      900

tttgctgctg ccaaccctgg ttacgccttc caccctttga tggctgccct gccggcctac      960

tttgccaaaa gtgccactat ctacaacccc gttatctatg tctttatgaa ccggcagttt     1020

cgaaactgca tcttgcagct tttcgggaag aaggttgacg atggctctga actctccagc     1080

gcctccaaaa cggaggtctc atctgtgtcc tcggtatcgc ctgcatgagg tctgcctcct     1140

acccatcccg cccaccgggg ctttggccac ctctcctttc cccctccttc tccatccctg     1200

taaaataaat gtaatttatc tttgccaaaa ccaa                                 1234


<210>  11
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Gln Gln Trp Ser Leu Gln Arg Leu Ala Gly Arg His Pro Gln 
1               5                   10                  15      


Asp Ser Tyr Glu Asp Ser Thr Gln Ser Ser Ile Phe Thr Tyr Thr Asn 
            20                  25                  30          


Ser Asn Ser Thr Arg Gly Pro Phe Glu Gly Pro Asn Tyr His Ile Ala 
        35                  40                  45              


Pro Arg Trp Val Tyr His Leu Thr Ser Val Trp Met Ile Phe Val Val 
    50                  55                  60                  


Thr Ala Ser Val Phe Thr Asn Gly Leu Val Leu Ala Ala Thr Met Lys 
65                  70                  75                  80  


Phe Lys Lys Leu Arg His Pro Leu Asn Trp Ile Leu Val Asn Leu Ala 
                85                  90                  95      


Val Ala Asp Leu Ala Glu Thr Val Ile Ala Ser Thr Ile Ser Ile Val 
            100                 105                 110         


Asn Gln Val Ser Gly Tyr Phe Val Leu Gly His Pro Met Cys Val Leu 
        115                 120                 125             


Glu Gly Tyr Thr Val Ser Leu Cys Gly Ile Thr Gly Leu Trp Ser Leu 
    130                 135                 140                 


Ala Ile Ile Ser Trp Glu Arg Trp Leu Val Val Cys Lys Pro Phe Gly 
145                 150                 155                 160 


Asn Val Arg Phe Asp Ala Lys Leu Ala Ile Val Gly Ile Ala Phe Ser 
                165                 170                 175     


Trp Ile Trp Ser Ala Val Trp Thr Ala Pro Pro Ile Phe Gly Trp Ser 
            180                 185                 190         


Arg Tyr Trp Pro His Gly Leu Lys Thr Ser Cys Gly Pro Asp Val Phe 
        195                 200                 205             


Ser Gly Ser Ser Tyr Pro Gly Val Gln Ser Tyr Met Ile Val Leu Met 
    210                 215                 220                 


Val Thr Cys Cys Ile Ile Pro Leu Ala Ile Ile Met Leu Cys Tyr Leu 
225                 230                 235                 240 


Gln Val Trp Leu Ala Ile Arg Ala Val Ala Lys Gln Gln Lys Glu Ser 
                245                 250                 255     


Glu Ser Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Val Val 
            260                 265                 270         


Met Ile Phe Ala Tyr Cys Val Cys Trp Gly Pro Tyr Thr Phe Phe Ala 
        275                 280                 285             


Cys Phe Ala Ala Ala Asn Pro Gly Tyr Ala Phe His Pro Leu Met Ala 
    290                 295                 300                 


Ala Leu Pro Ala Tyr Phe Ala Lys Ser Ala Thr Ile Tyr Asn Pro Val 
305                 310                 315                 320 


Ile Tyr Val Phe Met Asn Arg Gln Phe Arg Asn Cys Ile Leu Gln Leu 
                325                 330                 335     


Phe Gly Lys Lys Val Asp Asp Gly Ser Glu Leu Ser Ser Ala Ser Lys 
            340                 345                 350         


Thr Glu Val Ser Ser Val Ser Ser Val Ser Pro Ala 
        355                 360                 


<210>  12
<211>  7326
<212>  DNA
<213>  Homo sapiens

<400>  12
aggacacagc gtccggagcc agaggcgctc ttaacggcgt ttatgtcctt tgctgtctga       60

ggggcctcag ctctgaccaa tctggtcttc gtgtggtcat tagcatgggc ttcgtgagac      120

agatacagct tttgctctgg aagaactgga ccctgcggaa aaggcaaaag attcgctttg      180

tggtggaact cgtgtggcct ttatctttat ttctggtctt gatctggtta aggaatgcca      240

acccgctcta cagccatcat gaatgccatt tccccaacaa ggcgatgccc tcagcaggaa      300

tgctgccgtg gctccagggg atcttctgca atgtgaacaa tccctgtttt caaagcccca      360

ccccaggaga atctcctgga attgtgtcaa actataacaa ctccatcttg gcaagggtat      420

atcgagattt tcaagaactc ctcatgaatg caccagagag ccagcacctt ggccgtattt      480

ggacagagct acacatcttg tcccaattca tggacaccct ccggactcac ccggagagaa      540

ttgcaggaag aggaatacga ataagggata tcttgaaaga tgaagaaaca ctgacactat      600

ttctcattaa aaacatcggc ctgtctgact cagtggtcta ccttctgatc aactctcaag      660

tccgtccaga gcagttcgct catggagtcc cggacctggc gctgaaggac atcgcctgca      720

gcgaggccct cctggagcgc ttcatcatct tcagccagag acgcggggca aagacggtgc      780

gctatgccct gtgctccctc tcccagggca ccctacagtg gatagaagac actctgtatg      840

ccaacgtgga cttcttcaag ctcttccgtg tgcttcccac actcctagac agccgttctc      900

aaggtatcaa tctgagatct tggggaggaa tattatctga tatgtcacca agaattcaag      960

agtttatcca tcggccgagt atgcaggact tgctgtgggt gaccaggccc ctcatgcaga     1020

atggtggtcc agagaccttt acaaagctga tgggcatcct gtctgacctc ctgtgtggct     1080

accccgaggg aggtggctct cgggtgctct ccttcaactg gtatgaagac aataactata     1140

aggcctttct ggggattgac tccacaagga aggatcctat ctattcttat gacagaagaa     1200

caacatcctt ttgtaatgca ttgatccaga gcctggagtc aaatccttta accaaaatcg     1260

cttggagggc ggcaaagcct ttgctgatgg gaaaaatcct gtacactcct gattcacctg     1320

cagcacgaag gatactgaag aatgccaact caacttttga agaactggaa cacgttagga     1380

agttggtcaa agcctgggaa gaagtagggc cccagatctg gtacttcttt gacaacagca     1440

cacagatgaa catgatcaga gataccctgg ggaacccaac agtaaaagac tttttgaata     1500

ggcagcttgg tgaagaaggt attactgctg aagccatcct aaacttcctc tacaagggcc     1560

ctcgggaaag ccaggctgac gacatggcca acttcgactg gagggacata tttaacatca     1620

ctgatcgcac cctccgcctg gtcaatcaat acctggagtg cttggtcctg gataagtttg     1680

aaagctacaa tgatgaaact cagctcaccc aacgtgccct ctctctactg gaggaaaaca     1740

tgttctgggc cggagtggta ttccctgaca tgtatccctg gaccagctct ctaccacccc     1800

acgtgaagta taagatccga atggacatag acgtggtgga gaaaaccaat aagattaaag     1860

acaggtattg ggattctggt cccagagctg atcccgtgga agatttccgg tacatctggg     1920

gcgggtttgc ctatctgcag gacatggttg aacaggggat cacaaggagc caggtgcagg     1980

cggaggctcc agttggaatc tacctccagc agatgcccta cccctgcttc gtggacgatt     2040

ctttcatgat catcctgaac cgctgtttcc ctatcttcat ggtgctggca tggatctact     2100

ctgtctccat gactgtgaag agcatcgtct tggagaagga gttgcgactg aaggagacct     2160

tgaaaaatca gggtgtctcc aatgcagtga tttggtgtac ctggttcctg gacagcttct     2220

ccatcatgtc gatgagcatc ttcctcctga cgatattcat catgcatgga agaatcctac     2280

attacagcga cccattcatc ctcttcctgt tcttgttggc tttctccact gccaccatca     2340

tgctgtgctt tctgctcagc accttcttct ccaaggccag tctggcagca gcctgtagtg     2400

gtgtcatcta tttcaccctc tacctgccac acatcctgtg cttcgcctgg caggaccgca     2460

tgaccgctga gctgaagaag gctgtgagct tactgtctcc ggtggcattt ggatttggca     2520

ctgagtacct ggttcgcttt gaagagcaag gcctggggct gcagtggagc aacatcggga     2580

acagtcccac ggaaggggac gaattcagct tcctgctgtc catgcagatg atgctccttg     2640

atgctgctgt ctatggctta ctcgcttggt accttgatca ggtgtttcca ggagactatg     2700

gaaccccact tccttggtac tttcttctac aagagtcgta ttggcttggc ggtgaagggt     2760

gttcaaccag agaagaaaga gccctggaaa agaccgagcc cctaacagag gaaacggagg     2820

atccagagca cccagaagga atacacgact ccttctttga acgtgagcat ccagggtggg     2880

ttcctggggt atgcgtgaag aatctggtaa agatttttga gccctgtggc cggccagctg     2940

tggaccgtct gaacatcacc ttctacgaga accagatcac cgcattcctg ggccacaatg     3000

gagctgggaa aaccaccacc ttgtccatcc tgacgggtct gttgccacca acctctggga     3060

ctgtgctcgt tgggggaagg gacattgaaa ccagcctgga tgcagtccgg cagagccttg     3120

gcatgtgtcc acagcacaac atcctgttcc accacctcac ggtggctgag cacatgctgt     3180

tctatgccca gctgaaagga aagtcccagg aggaggccca gctggagatg gaagccatgt     3240

tggaggacac aggcctccac cacaagcgga atgaagaggc tcaggaccta tcaggtggca     3300

tgcagagaaa gctgtcggtt gccattgcct ttgtgggaga tgccaaggtg gtgattctgg     3360

acgaacccac ctctggggtg gacccttact cgagacgctc aatctgggat ctgctcctga     3420

agtatcgctc aggcagaacc atcatcatgt ccactcacca catggacgag gccgacctcc     3480

ttggggaccg cattgccatc attgcccagg gaaggctcta ctgctcaggc accccactct     3540

tcctgaagaa ctgctttggc acaggcttgt acttaacctt ggtgcgcaag atgaaaaaca     3600

tccagagcca aaggaaaggc agtgagggga cctgcagctg ctcgtctaag ggtttctcca     3660

ccacgtgtcc agcccacgtc gatgacctaa ctccagaaca agtcctggat ggggatgtaa     3720

atgagctgat ggatgtagtt ctccaccatg ttccagaggc aaagctggtg gagtgcattg     3780

gtcaagaact tatcttcctt cttccaaata agaacttcaa gcacagagca tatgccagcc     3840

ttttcagaga gctggaggag acgctggctg accttggtct cagcagtttt ggaatttctg     3900

acactcccct ggaagagatt tttctgaagg tcacggagga ttctgattca ggacctctgt     3960

ttgcgggtgg cgctcagcag aaaagagaaa acgtcaaccc ccgacacccc tgcttgggtc     4020

ccagagagaa ggctggacag acaccccagg actccaatgt ctgctcccca ggggcgccgg     4080

ctgctcaccc agagggccag cctcccccag agccagagtg cccaggcccg cagctcaaca     4140

cggggacaca gctggtcctc cagcatgtgc aggcgctgct ggtcaagaga ttccaacaca     4200

ccatccgcag ccacaaggac ttcctggcgc agatcgtgct cccggctacc tttgtgtttt     4260

tggctctgat gctttctatt gttatccctc cttttggcga ataccccgct ttgacccttc     4320

acccctggat atatgggcag cagtacacct tcttcagcat ggatgaacca ggcagtgagc     4380

agttcacggt acttgcagac gtcctcctga ataagccagg ctttggcaac cgctgcctga     4440

aggaagggtg gcttccggag tacccctgtg gcaactcaac accctggaag actccttctg     4500

tgtccccaaa catcacccag ctgttccaga agcagaaatg gacacaggtc aacccttcac     4560

catcctgcag gtgcagcacc agggagaagc tcaccatgct gccagagtgc cccgagggtg     4620

ccgggggcct cccgcccccc cagagaacac agcgcagcac ggaaattcta caagacctga     4680

cggacaggaa catctccgac ttcttggtaa aaacgtatcc tgctcttata agaagcagct     4740

taaagagcaa attctgggtc aatgaacaga ggtatggagg aatttccatt ggaggaaagc     4800

tcccagtcgt ccccatcacg ggggaagcac ttgttgggtt tttaagcgac cttggccgga     4860

tcatgaatgt gagcgggggc cctatcacta gagaggcctc taaagaaata cctgatttcc     4920

ttaaacatct agaaactgaa gacaacatta aggtgtggtt taataacaaa ggctggcatg     4980

ccctggtcag ctttctcaat gtggcccaca acgccatctt acgggccagc ctgcctaagg     5040

acaggagccc cgaggagtat ggaatcaccg tcattagcca acccctgaac ctgaccaagg     5100

agcagctctc agagattaca gtgctgacca cttcagtgga tgctgtggtt gccatctgcg     5160

tgattttctc catgtccttc gtcccagcca gctttgtcct ttatttgatc caggagcggg     5220

tgaacaaatc caagcacctc cagtttatca gtggagtgag ccccaccacc tactgggtga     5280

ccaacttcct ctgggacatc atgaattatt ccgtgagtgc tgggctggtg gtgggcatct     5340

tcatcgggtt tcagaagaaa gcctacactt ctccagaaaa ccttcctgcc cttgtggcac     5400

tgctcctgct gtatggatgg gcggtcattc ccatgatgta cccagcatcc ttcctgtttg     5460

atgtccccag cacagcctat gtggctttat cttgtgctaa tctgttcatc ggcatcaaca     5520

gcagtgctat taccttcatc ttggaattat ttgagaataa ccggacgctg ctcaggttca     5580

acgccgtgct gaggaagctg ctcattgtct tcccccactt ctgcctgggc cggggcctca     5640

ttgaccttgc actgagccag gctgtgacag atgtctatgc ccggtttggt gaggagcact     5700

ctgcaaatcc gttccactgg gacctgattg ggaagaacct gtttgccatg gtggtggaag     5760

gggtggtgta cttcctcctg accctgctgg tccagcgcca cttcttcctc tcccaatgga     5820

ttgccgagcc cactaaggag cccattgttg atgaagatga tgatgtggct gaagaaagac     5880

aaagaattat tactggtgga aataaaactg acatcttaag gctacatgaa ctaaccaaga     5940

tttatccagg cacctccagc ccagcagtgg acaggctgtg tgtcggagtt cgccctggag     6000

agtgctttgg cctcctggga gtgaatggtg ccggcaaaac aaccacattc aagatgctca     6060

ctggggacac cacagtgacc tcaggggatg ccaccgtagc aggcaagagt attttaacca     6120

atatttctga agtccatcaa aatatgggct actgtcctca gtttgatgca attgatgagc     6180

tgctcacagg acgagaacat ctttaccttt atgcccggct tcgaggtgta ccagcagaag     6240

aaatcgaaaa ggttgcaaac tggagtatta agagcctggg cctgactgtc tacgccgact     6300

gcctggctgg cacgtacagt gggggcaaca agcggaaact ctccacagcc atcgcactca     6360

ttggctgccc accgctggtg ctgctggatg agcccaccac agggatggac ccccaggcac     6420

gccgcatgct gtggaacgtc atcgtgagca tcatcagaga agggagggct gtggtcctca     6480

catcccacag catggaagaa tgtgaggcac tgtgtacccg gctggccatc atggtaaagg     6540

gcgcctttcg atgtatgggc accattcagc atctcaagtc caaatttgga gatggctata     6600

tcgtcacaat gaagatcaaa tccccgaagg acgacctgct tcctgacctg aaccctgtgg     6660

agcagttctt ccaggggaac ttcccaggca gtgtgcagag ggagaggcac tacaacatgc     6720

tccagttcca ggtctcctcc tcctccctgg cgaggatctt ccagctcctc ctctcccaca     6780

aggacagcct gctcatcgag gagtactcag tcacacagac cacactggac caggtgtttg     6840

taaattttgc taaacagcag actgaaagtc atgacctccc tctgcaccct cgagctgctg     6900

gagccagtcg acaagcccag gactgatctt tcacaccgct cgttcctgca gccagaaagg     6960

aactctgggc agctggaggc gcaggagcct gtgcccatat ggtcatccaa atggactggc     7020

cagcgtaaat gaccccactg cagcagaaaa caaacacacg aggagcatgc agcgaattca     7080

gaaagaggtc tttcagaagg aaaccgaaac tgacttgctc acctggaaca cctgatggtg     7140

aaaccaaaca aatacaaaat ccttctccag accccagaac tagaaacccc gggccatccc     7200

actagcagct ttggcctcca tattgctctc atttcaagca gatctgcttt tctgcatgtt     7260

tgtctgtgtg tctgcgttgt gtgtgatttt catggaaaaa taaaatgcaa atgcactcat     7320

cacaaa                                                                7326


<210>  13
<211>  2273
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      


Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          


Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              


Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  


Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  


Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      


Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         


Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             


Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 


Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 


Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     


Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         


His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             


Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 


Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 


Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     


Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         


Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             


His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 


Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 


Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     


Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         


Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             


Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 


Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 


Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     


Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         


Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             


Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 


Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 


Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     


Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         


Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             


Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 


Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 


Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     


Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         


Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             


Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 


Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 


Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     


Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         


Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             


Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 


Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 


His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     


Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         


Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             


Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 


Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 


Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     


Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         


Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             


Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 


Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 


Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     


Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         


Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             


Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 


Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 


Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     


Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         


Asp Ile Glu Thr Ser Leu Asp Ala  Val Arg Gln Ser Leu  Gly Met Cys 
        995                 1000                 1005             


Pro Gln  His Asn Ile Leu Phe  His His Leu Thr Val  Ala Glu His 
    1010                 1015                 1020             


Met Leu  Phe Tyr Ala Gln Leu  Lys Gly Lys Ser Gln  Glu Glu Ala 
    1025                 1030                 1035             


Gln Leu  Glu Met Glu Ala Met  Leu Glu Asp Thr Gly  Leu His His 
    1040                 1045                 1050             


Lys Arg  Asn Glu Glu Ala Gln  Asp Leu Ser Gly Gly  Met Gln Arg 
    1055                 1060                 1065             


Lys Leu  Ser Val Ala Ile Ala  Phe Val Gly Asp Ala  Lys Val Val 
    1070                 1075                 1080             


Ile Leu  Asp Glu Pro Thr Ser  Gly Val Asp Pro Tyr  Ser Arg Arg 
    1085                 1090                 1095             


Ser Ile  Trp Asp Leu Leu Leu  Lys Tyr Arg Ser Gly  Arg Thr Ile 
    1100                 1105                 1110             


Ile Met  Ser Thr His His Met  Asp Glu Ala Asp Leu  Leu Gly Asp 
    1115                 1120                 1125             


Arg Ile  Ala Ile Ile Ala Gln  Gly Arg Leu Tyr Cys  Ser Gly Thr 
    1130                 1135                 1140             


Pro Leu  Phe Leu Lys Asn Cys  Phe Gly Thr Gly Leu  Tyr Leu Thr 
    1145                 1150                 1155             


Leu Val  Arg Lys Met Lys Asn  Ile Gln Ser Gln Arg  Lys Gly Ser 
    1160                 1165                 1170             


Glu Gly  Thr Cys Ser Cys Ser  Ser Lys Gly Phe Ser  Thr Thr Cys 
    1175                 1180                 1185             


Pro Ala  His Val Asp Asp Leu  Thr Pro Glu Gln Val  Leu Asp Gly 
    1190                 1195                 1200             


Asp Val  Asn Glu Leu Met Asp  Val Val Leu His His  Val Pro Glu 
    1205                 1210                 1215             


Ala Lys  Leu Val Glu Cys Ile  Gly Gln Glu Leu Ile  Phe Leu Leu 
    1220                 1225                 1230             


Pro Asn  Lys Asn Phe Lys His  Arg Ala Tyr Ala Ser  Leu Phe Arg 
    1235                 1240                 1245             


Glu Leu  Glu Glu Thr Leu Ala  Asp Leu Gly Leu Ser  Ser Phe Gly 
    1250                 1255                 1260             


Ile Ser  Asp Thr Pro Leu Glu  Glu Ile Phe Leu Lys  Val Thr Glu 
    1265                 1270                 1275             


Asp Ser  Asp Ser Gly Pro Leu  Phe Ala Gly Gly Ala  Gln Gln Lys 
    1280                 1285                 1290             


Arg Glu  Asn Val Asn Pro Arg  His Pro Cys Leu Gly  Pro Arg Glu 
    1295                 1300                 1305             


Lys Ala  Gly Gln Thr Pro Gln  Asp Ser Asn Val Cys  Ser Pro Gly 
    1310                 1315                 1320             


Ala Pro  Ala Ala His Pro Glu  Gly Gln Pro Pro Pro  Glu Pro Glu 
    1325                 1330                 1335             


Cys Pro  Gly Pro Gln Leu Asn  Thr Gly Thr Gln Leu  Val Leu Gln 
    1340                 1345                 1350             


His Val  Gln Ala Leu Leu Val  Lys Arg Phe Gln His  Thr Ile Arg 
    1355                 1360                 1365             


Ser His  Lys Asp Phe Leu Ala  Gln Ile Val Leu Pro  Ala Thr Phe 
    1370                 1375                 1380             


Val Phe  Leu Ala Leu Met Leu  Ser Ile Val Ile Pro  Pro Phe Gly 
    1385                 1390                 1395             


Glu Tyr  Pro Ala Leu Thr Leu  His Pro Trp Ile Tyr  Gly Gln Gln 
    1400                 1405                 1410             


Tyr Thr  Phe Phe Ser Met Asp  Glu Pro Gly Ser Glu  Gln Phe Thr 
    1415                 1420                 1425             


Val Leu  Ala Asp Val Leu Leu  Asn Lys Pro Gly Phe  Gly Asn Arg 
    1430                 1435                 1440             


Cys Leu  Lys Glu Gly Trp Leu  Pro Glu Tyr Pro Cys  Gly Asn Ser 
    1445                 1450                 1455             


Thr Pro  Trp Lys Thr Pro Ser  Val Ser Pro Asn Ile  Thr Gln Leu 
    1460                 1465                 1470             


Phe Gln  Lys Gln Lys Trp Thr  Gln Val Asn Pro Ser  Pro Ser Cys 
    1475                 1480                 1485             


Arg Cys  Ser Thr Arg Glu Lys  Leu Thr Met Leu Pro  Glu Cys Pro 
    1490                 1495                 1500             


Glu Gly  Ala Gly Gly Leu Pro  Pro Pro Gln Arg Thr  Gln Arg Ser 
    1505                 1510                 1515             


Thr Glu  Ile Leu Gln Asp Leu  Thr Asp Arg Asn Ile  Ser Asp Phe 
    1520                 1525                 1530             


Leu Val  Lys Thr Tyr Pro Ala  Leu Ile Arg Ser Ser  Leu Lys Ser 
    1535                 1540                 1545             


Lys Phe  Trp Val Asn Glu Gln  Arg Tyr Gly Gly Ile  Ser Ile Gly 
    1550                 1555                 1560             


Gly Lys  Leu Pro Val Val Pro  Ile Thr Gly Glu Ala  Leu Val Gly 
    1565                 1570                 1575             


Phe Leu  Ser Asp Leu Gly Arg  Ile Met Asn Val Ser  Gly Gly Pro 
    1580                 1585                 1590             


Ile Thr  Arg Glu Ala Ser Lys  Glu Ile Pro Asp Phe  Leu Lys His 
    1595                 1600                 1605             


Leu Glu  Thr Glu Asp Asn Ile  Lys Val Trp Phe Asn  Asn Lys Gly 
    1610                 1615                 1620             


Trp His  Ala Leu Val Ser Phe  Leu Asn Val Ala His  Asn Ala Ile 
    1625                 1630                 1635             


Leu Arg  Ala Ser Leu Pro Lys  Asp Arg Ser Pro Glu  Glu Tyr Gly 
    1640                 1645                 1650             


Ile Thr  Val Ile Ser Gln Pro  Leu Asn Leu Thr Lys  Glu Gln Leu 
    1655                 1660                 1665             


Ser Glu  Ile Thr Val Leu Thr  Thr Ser Val Asp Ala  Val Val Ala 
    1670                 1675                 1680             


Ile Cys  Val Ile Phe Ser Met  Ser Phe Val Pro Ala  Ser Phe Val 
    1685                 1690                 1695             


Leu Tyr  Leu Ile Gln Glu Arg  Val Asn Lys Ser Lys  His Leu Gln 
    1700                 1705                 1710             


Phe Ile  Ser Gly Val Ser Pro  Thr Thr Tyr Trp Val  Thr Asn Phe 
    1715                 1720                 1725             


Leu Trp  Asp Ile Met Asn Tyr  Ser Val Ser Ala Gly  Leu Val Val 
    1730                 1735                 1740             


Gly Ile  Phe Ile Gly Phe Gln  Lys Lys Ala Tyr Thr  Ser Pro Glu 
    1745                 1750                 1755             


Asn Leu  Pro Ala Leu Val Ala  Leu Leu Leu Leu Tyr  Gly Trp Ala 
    1760                 1765                 1770             


Val Ile  Pro Met Met Tyr Pro  Ala Ser Phe Leu Phe  Asp Val Pro 
    1775                 1780                 1785             


Ser Thr  Ala Tyr Val Ala Leu  Ser Cys Ala Asn Leu  Phe Ile Gly 
    1790                 1795                 1800             


Ile Asn  Ser Ser Ala Ile Thr  Phe Ile Leu Glu Leu  Phe Glu Asn 
    1805                 1810                 1815             


Asn Arg  Thr Leu Leu Arg Phe  Asn Ala Val Leu Arg  Lys Leu Leu 
    1820                 1825                 1830             


Ile Val  Phe Pro His Phe Cys  Leu Gly Arg Gly Leu  Ile Asp Leu 
    1835                 1840                 1845             


Ala Leu  Ser Gln Ala Val Thr  Asp Val Tyr Ala Arg  Phe Gly Glu 
    1850                 1855                 1860             


Glu His  Ser Ala Asn Pro Phe  His Trp Asp Leu Ile  Gly Lys Asn 
    1865                 1870                 1875             


Leu Phe  Ala Met Val Val Glu  Gly Val Val Tyr Phe  Leu Leu Thr 
    1880                 1885                 1890             


Leu Leu  Val Gln Arg His Phe  Phe Leu Ser Gln Trp  Ile Ala Glu 
    1895                 1900                 1905             


Pro Thr  Lys Glu Pro Ile Val  Asp Glu Asp Asp Asp  Val Ala Glu 
    1910                 1915                 1920             


Glu Arg  Gln Arg Ile Ile Thr  Gly Gly Asn Lys Thr  Asp Ile Leu 
    1925                 1930                 1935             


Arg Leu  His Glu Leu Thr Lys  Ile Tyr Pro Gly Thr  Ser Ser Pro 
    1940                 1945                 1950             


Ala Val  Asp Arg Leu Cys Val  Gly Val Arg Pro Gly  Glu Cys Phe 
    1955                 1960                 1965             


Gly Leu  Leu Gly Val Asn Gly  Ala Gly Lys Thr Thr  Thr Phe Lys 
    1970                 1975                 1980             


Met Leu  Thr Gly Asp Thr Thr  Val Thr Ser Gly Asp  Ala Thr Val 
    1985                 1990                 1995             


Ala Gly  Lys Ser Ile Leu Thr  Asn Ile Ser Glu Val  His Gln Asn 
    2000                 2005                 2010             


Met Gly  Tyr Cys Pro Gln Phe  Asp Ala Ile Asp Glu  Leu Leu Thr 
    2015                 2020                 2025             


Gly Arg  Glu His Leu Tyr Leu  Tyr Ala Arg Leu Arg  Gly Val Pro 
    2030                 2035                 2040             


Ala Glu  Glu Ile Glu Lys Val  Ala Asn Trp Ser Ile  Lys Ser Leu 
    2045                 2050                 2055             


Gly Leu  Thr Val Tyr Ala Asp  Cys Leu Ala Gly Thr  Tyr Ser Gly 
    2060                 2065                 2070             


Gly Asn  Lys Arg Lys Leu Ser  Thr Ala Ile Ala Leu  Ile Gly Cys 
    2075                 2080                 2085             


Pro Pro  Leu Val Leu Leu Asp  Glu Pro Thr Thr Gly  Met Asp Pro 
    2090                 2095                 2100             


Gln Ala  Arg Arg Met Leu Trp  Asn Val Ile Val Ser  Ile Ile Arg 
    2105                 2110                 2115             


Glu Gly  Arg Ala Val Val Leu  Thr Ser His Ser Met  Glu Glu Cys 
    2120                 2125                 2130             


Glu Ala  Leu Cys Thr Arg Leu  Ala Ile Met Val Lys  Gly Ala Phe 
    2135                 2140                 2145             


Arg Cys  Met Gly Thr Ile Gln  His Leu Lys Ser Lys  Phe Gly Asp 
    2150                 2155                 2160             


Gly Tyr  Ile Val Thr Met Lys  Ile Lys Ser Pro Lys  Asp Asp Leu 
    2165                 2170                 2175             


Leu Pro  Asp Leu Asn Pro Val  Glu Gln Phe Phe Gln  Gly Asn Phe 
    2180                 2185                 2190             


Pro Gly  Ser Val Gln Arg Glu  Arg His Tyr Asn Met  Leu Gln Phe 
    2195                 2200                 2205             


Gln Val  Ser Ser Ser Ser Leu  Ala Arg Ile Phe Gln  Leu Leu Leu 
    2210                 2215                 2220             


Ser His  Lys Asp Ser Leu Leu  Ile Glu Glu Tyr Ser  Val Thr Gln 
    2225                 2230                 2235             


Thr Thr  Leu Asp Gln Val Phe  Val Asn Phe Ala Lys  Gln Gln Thr 
    2240                 2245                 2250             


Glu Ser  His Asp Leu Pro Leu  His Pro Arg Ala Ala  Gly Ala Ser 
    2255                 2260                 2265             


Arg Gln  Ala Gln Asp 
    2270             


<210>  14
<211>  2608
<212>  DNA
<213>  Homo sapiens

<400>  14
tccttcttca ttctgcagtt ggtgccagaa ctctggatcc tgaactggaa gaaaatgtct       60

atccaggttg agcatcctgc tggtggttac aagaaactgt ttgaaactgt ggaggaactg      120

tcctcgccgc tcacagctca tgtaacaggc aggatccccc tctggctcac cggcagtctc      180

cttcgatgtg ggccaggact ctttgaagtt ggatctgagc cattttacca cctgtttgat      240

gggcaagccc tcctgcacaa gtttgacttt aaagaaggac atgtcacata ccacagaagg      300

ttcatccgca ctgatgctta cgtacgggca atgactgaga aaaggatcgt cataacagaa      360

tttggcacct gtgctttccc agatccctgc aagaatatat tttccaggtt tttttcttac      420

tttcgaggag tagaggttac tgacaatgcc cttgttaatg tctacccagt gggggaagat      480

tactacgctt gcacagagac caactttatt acaaagatta atccagagac cttggagaca      540

attaagcagg ttgatctttg caactatgtc tctgtcaatg gggccactgc tcacccccac      600

attgaaaatg atggaaccgt ttacaatatt ggtaattgct ttggaaaaaa tttttcaatt      660

gcctacaaca ttgtaaagat cccaccactg caagcagaca aggaagatcc aataagcaag      720

tcagagatcg ttgtacaatt cccctgcagt gaccgattca agccatctta cgttcatagt      780

tttggtctga ctcccaacta tatcgttttt gtggagacac cagtcaaaat taacctgttc      840

aagttccttt cttcatggag tctttgggga gccaactaca tggattgttt tgagtccaat      900

gaaaccatgg gggtttggct tcatattgct gacaaaaaaa ggaaaaagta cctcaataat      960

aaatacagaa cttctccttt caacctcttc catcacatca acacctatga agacaatggg     1020

tttctgattg tggatctctg ctgctggaaa ggatttgagt ttgtttataa ttacttatat     1080

ttagccaatt tacgtgagaa ctgggaagag gtgaaaaaaa atgccagaaa ggctccccaa     1140

cctgaagtta ggagatatgt acttcctttg aatattgaca aggctgacac aggcaagaat     1200

ttagtcacgc tccccaatac aactgccact gcaattctgt gcagtgacga gactatctgg     1260

ctggagcctg aagttctctt ttcagggcct cgtcaagcat ttgagtttcc tcaaatcaat     1320

taccagaagt attgtgggaa accttacaca tatgcgtatg gacttggctt gaatcacttt     1380

gttccagata ggctctgtaa gctgaatgtc aaaactaaag aaacttgggt ttggcaagag     1440

cctgattcat acccatcaga acccatcttt gtttctcacc cagatgcctt ggaagaagat     1500

gatggtgtag ttctgagtgt ggtggtgagc ccaggagcag gacaaaagcc tgcttatctc     1560

ctgattctga atgccaagga cttaagtgaa gttgcccggg ctgaagtgga gattaacatc     1620

cctgtcacct ttcatggact gttcaaaaaa tcttgagcat actccagcaa gatatgtttt     1680

tggtagcaaa actgagaaaa tcagcttcag gtctgcaatc aaattctgtt caattttagc     1740

ctgctatatg tcatggtttt aacttgcaga tgcgcacaat tttgcaatgt tttacagaaa     1800

gcactgagtt gagcaagcaa ttcctttatt taaaaaaaaa agtacgtatt tagataatca     1860

tacttcctct gtgagacagg ccataactga aaaactctta aatatttagc aatcaaatag     1920

gaaatgaatg tggacttact aaatggcttt taattcctat tataagagca tattttaggt     1980

acctatctgc tccaattata tttttaacat ttaaaaacca aagtcctcta cacttgattt     2040

atattatatg tggctttgct gagtcaagga agtatcatgc aataaggctt aattactaaa     2100

tgtcaaacca aactttttct caaaccaggg actatcatct aagattaatt acagtaatta     2160

ttttgcgtat acgtaactgc tcaaagatta tgaatcttat gaatgttaac ctttccgttt     2220

attacaagca agtactatta tttctgattt tataataaga aaatctgtgt ttaatcaact     2280

gaggcctctc aaccaaataa catctcagag attaagttat atattaaaag cttatgtaac     2340

ataaaagcaa gtacatatag tagtgactat atttaaaaaa acagcataaa atgcttaaaa     2400

atgtaatatt tactaaaatc agattatggg ataatgttgc aggattatac tttattgcat     2460

cttttttgtt taattgtatt taagcattgt gcaatcactt gggaaaaata ttaaattatt     2520

aacattgagg tattaataca ttttaagcct tttgttttta aatttctttt cttccagaga     2580

ttgtttaaaa ataaatattg acaaaaat                                        2608


<210>  15
<211>  533
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Ile Gln Val Glu His Pro Ala Gly Gly Tyr Lys Lys Leu Phe 
1               5                   10                  15      


Glu Thr Val Glu Glu Leu Ser Ser Pro Leu Thr Ala His Val Thr Gly 
            20                  25                  30          


Arg Ile Pro Leu Trp Leu Thr Gly Ser Leu Leu Arg Cys Gly Pro Gly 
        35                  40                  45              


Leu Phe Glu Val Gly Ser Glu Pro Phe Tyr His Leu Phe Asp Gly Gln 
    50                  55                  60                  


Ala Leu Leu His Lys Phe Asp Phe Lys Glu Gly His Val Thr Tyr His 
65                  70                  75                  80  


Arg Arg Phe Ile Arg Thr Asp Ala Tyr Val Arg Ala Met Thr Glu Lys 
                85                  90                  95      


Arg Ile Val Ile Thr Glu Phe Gly Thr Cys Ala Phe Pro Asp Pro Cys 
            100                 105                 110         


Lys Asn Ile Phe Ser Arg Phe Phe Ser Tyr Phe Arg Gly Val Glu Val 
        115                 120                 125             


Thr Asp Asn Ala Leu Val Asn Val Tyr Pro Val Gly Glu Asp Tyr Tyr 
    130                 135                 140                 


Ala Cys Thr Glu Thr Asn Phe Ile Thr Lys Ile Asn Pro Glu Thr Leu 
145                 150                 155                 160 


Glu Thr Ile Lys Gln Val Asp Leu Cys Asn Tyr Val Ser Val Asn Gly 
                165                 170                 175     


Ala Thr Ala His Pro His Ile Glu Asn Asp Gly Thr Val Tyr Asn Ile 
            180                 185                 190         


Gly Asn Cys Phe Gly Lys Asn Phe Ser Ile Ala Tyr Asn Ile Val Lys 
        195                 200                 205             


Ile Pro Pro Leu Gln Ala Asp Lys Glu Asp Pro Ile Ser Lys Ser Glu 
    210                 215                 220                 


Ile Val Val Gln Phe Pro Cys Ser Asp Arg Phe Lys Pro Ser Tyr Val 
225                 230                 235                 240 


His Ser Phe Gly Leu Thr Pro Asn Tyr Ile Val Phe Val Glu Thr Pro 
                245                 250                 255     


Val Lys Ile Asn Leu Phe Lys Phe Leu Ser Ser Trp Ser Leu Trp Gly 
            260                 265                 270         


Ala Asn Tyr Met Asp Cys Phe Glu Ser Asn Glu Thr Met Gly Val Trp 
        275                 280                 285             


Leu His Ile Ala Asp Lys Lys Arg Lys Lys Tyr Leu Asn Asn Lys Tyr 
    290                 295                 300                 


Arg Thr Ser Pro Phe Asn Leu Phe His His Ile Asn Thr Tyr Glu Asp 
305                 310                 315                 320 


Asn Gly Phe Leu Ile Val Asp Leu Cys Cys Trp Lys Gly Phe Glu Phe 
                325                 330                 335     


Val Tyr Asn Tyr Leu Tyr Leu Ala Asn Leu Arg Glu Asn Trp Glu Glu 
            340                 345                 350         


Val Lys Lys Asn Ala Arg Lys Ala Pro Gln Pro Glu Val Arg Arg Tyr 
        355                 360                 365             


Val Leu Pro Leu Asn Ile Asp Lys Ala Asp Thr Gly Lys Asn Leu Val 
    370                 375                 380                 


Thr Leu Pro Asn Thr Thr Ala Thr Ala Ile Leu Cys Ser Asp Glu Thr 
385                 390                 395                 400 


Ile Trp Leu Glu Pro Glu Val Leu Phe Ser Gly Pro Arg Gln Ala Phe 
                405                 410                 415     


Glu Phe Pro Gln Ile Asn Tyr Gln Lys Tyr Cys Gly Lys Pro Tyr Thr 
            420                 425                 430         


Tyr Ala Tyr Gly Leu Gly Leu Asn His Phe Val Pro Asp Arg Leu Cys 
        435                 440                 445             


Lys Leu Asn Val Lys Thr Lys Glu Thr Trp Val Trp Gln Glu Pro Asp 
    450                 455                 460                 


Ser Tyr Pro Ser Glu Pro Ile Phe Val Ser His Pro Asp Ala Leu Glu 
465                 470                 475                 480 


Glu Asp Asp Gly Val Val Leu Ser Val Val Val Ser Pro Gly Ala Gly 
                485                 490                 495     


Gln Lys Pro Ala Tyr Leu Leu Ile Leu Asn Ala Lys Asp Leu Ser Glu 
            500                 505                 510         


Val Ala Arg Ala Glu Val Glu Ile Asn Ile Pro Val Thr Phe His Gly 
        515                 520                 525             


Leu Phe Lys Lys Ser 
    530             


<210>  16
<211>  1752
<212>  DNA
<213>  Homo sapiens

<400>  16
gagcccgatt taacggaaac tgtgggcggt gagaagttcc ttatgacaca ctaatcccaa       60

cctgctgacc ggaccacgcc tccagcggag ggaacctcta gagctccagg acattcaggt      120

accaggtagc cccaaggagg agctgccgac ctggcaggga acaaccaaga ctggggttaa      180

atctcacagc ctgcaagtgg aagagaagaa cttgaaccca ggtccaactt ttgcgccaca      240

gcaggctgcc tcttggtcct gacaggaagt cacaacttgg ccctgacttc ctatcctagg      300

gaaggggccg gctggagagg ccaggacaga gaaagcagat cccttctttt tccaaggact      360

ctgtgtcttc cataggcaac atgtcagaag gggtgggcac gttccgcatg gtacctgaag      420

aggaacagga gctccgtgcc caactggagc agctcacaac caaggaccat ggacctgtct      480

ttggcccgtg cagccagctg ccccgccaca ccttgcagaa ggccaaggat gagctgaacg      540

agagagagga gacccgggag gaggcagtgc gagagctgca ggagatggtg caggcgcagg      600

cggcctcggg ggaggagctg gcggtggccg tggcggagag ggtgcaagag aaggacagcg      660

gcttcttcct gcgcttcatc cgcgcacgga agttcaacgt gggccgtgcc tatgagctgc      720

tcagaggcta tgtgaatttc cggctgcagt accctgagct ctttgacagc ctgtccccag      780

aggctgtccg ctgcaccatt gaagctggct accctggtgt cctctctagt cgggacaagt      840

atggccgagt ggtcatgctc ttcaacattg agaactggca aagtcaagaa atcacctttg      900

atgagatctt gcaggcatat tgcttcatcc tggagaagct gctggagaat gaggaaactc      960

aaatcaatgg cttctgcatc attgagaact tcaagggctt taccatgcag caggctgcta     1020

gtctccggac ttcagatctc aggaagatgg tggacatgct ccaggattcc ttcccagccc     1080

ggttcaaagc catccacttc atccaccagc catggtactt caccacgacc tacaatgtgg     1140

tcaagccctt cttgaagagc aagctgcttg agagggtctt tgtccacggg gatgaccttt     1200

ctggtttcta ccaggagatc gatgagaaca tcctgccctc tgacttcggg ggcacgctgc     1260

ccaagtatga tggcaaggcc gttgctgagc agctctttgg cccccaggcc caagctgaga     1320

acacagcctt ctgaaaacat ctcctgccag ctgaactgta gttagaatct ctgggcctct     1380

cctcaactgt cctggaccca aggctaggaa agggctgctt gagatgactg tggtcccccc     1440

ttagactccc taagcccgag tgagctcagg tgtcaccctg ttctcaagtt gggggatggg     1500

taataaagga gggggaattc ccttgaacaa gaagaactgg ggatagttat atttccacct     1560

gcccttgaag ctttaagaca gtgatttttg tgtaaggttg tatttcaaag actcgaattc     1620

attttctcag tcatttcctt tgtaacagag ttttacgact tagagtctgt gaaaacaggc     1680

aaggagcccg ggttaaaata tccccctatt cgcccccaaa atgcaataaa agaagataaa     1740

agagagagga ta                                                         1752


<210>  17
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ser Glu Gly Val Gly Thr Phe Arg Met Val Pro Glu Glu Glu Gln 
1               5                   10                  15      


Glu Leu Arg Ala Gln Leu Glu Gln Leu Thr Thr Lys Asp His Gly Pro 
            20                  25                  30          


Val Phe Gly Pro Cys Ser Gln Leu Pro Arg His Thr Leu Gln Lys Ala 
        35                  40                  45              


Lys Asp Glu Leu Asn Glu Arg Glu Glu Thr Arg Glu Glu Ala Val Arg 
    50                  55                  60                  


Glu Leu Gln Glu Met Val Gln Ala Gln Ala Ala Ser Gly Glu Glu Leu 
65                  70                  75                  80  


Ala Val Ala Val Ala Glu Arg Val Gln Glu Lys Asp Ser Gly Phe Phe 
                85                  90                  95      


Leu Arg Phe Ile Arg Ala Arg Lys Phe Asn Val Gly Arg Ala Tyr Glu 
            100                 105                 110         


Leu Leu Arg Gly Tyr Val Asn Phe Arg Leu Gln Tyr Pro Glu Leu Phe 
        115                 120                 125             


Asp Ser Leu Ser Pro Glu Ala Val Arg Cys Thr Ile Glu Ala Gly Tyr 
    130                 135                 140                 


Pro Gly Val Leu Ser Ser Arg Asp Lys Tyr Gly Arg Val Val Met Leu 
145                 150                 155                 160 


Phe Asn Ile Glu Asn Trp Gln Ser Gln Glu Ile Thr Phe Asp Glu Ile 
                165                 170                 175     


Leu Gln Ala Tyr Cys Phe Ile Leu Glu Lys Leu Leu Glu Asn Glu Glu 
            180                 185                 190         


Thr Gln Ile Asn Gly Phe Cys Ile Ile Glu Asn Phe Lys Gly Phe Thr 
        195                 200                 205             


Met Gln Gln Ala Ala Ser Leu Arg Thr Ser Asp Leu Arg Lys Met Val 
    210                 215                 220                 


Asp Met Leu Gln Asp Ser Phe Pro Ala Arg Phe Lys Ala Ile His Phe 
225                 230                 235                 240 


Ile His Gln Pro Trp Tyr Phe Thr Thr Thr Tyr Asn Val Val Lys Pro 
                245                 250                 255     


Phe Leu Lys Ser Lys Leu Leu Glu Arg Val Phe Val His Gly Asp Asp 
            260                 265                 270         


Leu Ser Gly Phe Tyr Gln Glu Ile Asp Glu Asn Ile Leu Pro Ser Asp 
        275                 280                 285             


Phe Gly Gly Thr Leu Pro Lys Tyr Asp Gly Lys Ala Val Ala Glu Gln 
    290                 295                 300                 


Leu Phe Gly Pro Gln Ala Gln Ala Glu Asn Thr Ala Phe 
305                 310                 315         


<210>  18
<211>  3027
<212>  DNA
<213>  Homo sapiens

<400>  18
cagcgttcag gctgcccctt cttggctggg aagggcgctg aagaaacaac gcccaggacc       60

aggactatcc cctgctcaag ctgtgattcc gagacccctg ccaccactac tgcattcacg      120

gggatcccag gctagtggga ctcgacatgg gtagccccca gggcagctcc ctacagcttg      180

ggccatctgc acttttccca aggccctaag tctccgcctc tgggctcgtt aaggtttggg      240

gtgggagctg tgctgtggga agcaacccgg actacacttg gcaagcatgg cgctactgaa      300

agtcaagttt gaccagaaga agcgggtcaa gttggcccaa gggctctggc tcatgaactg      360

gttctccgtg ttggctggca tcatcatctt cagcctagga ctgttcctga agattgaact      420

ccgaaagagg agcgatgtga tgaataattc tgagagccat tttgtgccca actcattgat      480

agggatgggg gtgctatcct gtgtcttcaa ctcgctggct gggaagatct gctacgacgc      540

cctggaccca gccaagtatg ccagatggaa gccctggctg aagccgtacc tggctatctg      600

tgttctcttc aacatcatcc tcttccttgt ggctctctgc tgctttctgc ttcggggctc      660

gctggagaac accctgggcc aagggctcaa gaacggcatg aagtactacc gggacacaga      720

cacccctggc aggtgtttca tgaagaagac catcgacatg ctgcagatcg agttcaaatg      780

ctgcggcaac aacggttttc gggactggtt tgagattcag tggatcagca atcgctacct      840

ggacttttcc tccaaagaag tcaaagatcg aatcaagagc aacgtggatg ggcggtacct      900

ggtggacggc gtccctttca gctgctgcaa tcctagctcg ccacggccct gcatccagta      960

tcagatcacc aacaactcag cacactacag ttacgaccac cagacggagg agctcaacct     1020

gtgggtgcgt ggctgcaggg ctgccctgct gagctactac agcagcctca tgaactccat     1080

gggtgtcgtc acgctcctca tttggctctt cgaggtgacc attacaattg ggctgcgcta     1140

cctacagacg tcgctggatg gtgtgtccaa ccccgaggaa tctgagagcg agagccaggg     1200

ctggctgctg gagaggagcg tgccggagac ctggaaggcc tttctggaga gtgtgaagaa     1260

gctgggcaag ggcaaccagg tggaagccga gggcgcagac gcaggccagg ccccagaggc     1320

tggctgaggg ccctggggcc cctcccctcc cgaacactga gaaatagtgc actccaagaa     1380

acgtggatct ccccctcatc caactccgaa agtctgaatc tcccaaggag ggcaccatct     1440

tacagagact ctccctgacg gtggaattta agtttagggt ccctaaaagc atttgacaca     1500

cagttgttga atgactgacc caaaatgtga atgaagctaa tgtgaatgtg agtgaagctc     1560

ccttcaggcc cgctgcccta ggatatgccc tcctggtgac tcgggggctg tctcagacga     1620

ctagcccagg acccatcttt ctcacacgga tttagtccca ccctatggcc actggccgta     1680

tctgagggct gctccccttt tagaatttac ctcttatgag ctccatgttg cttcactcta     1740

tccaaagtgt cacttggtgc ataagcacag aaatctgaaa aatggccatg ttgtcttttt     1800

tttttttttt taatgccaag attgacaggt tggccgtttg cttaatgcca gaagttgggg     1860

gaaagttacg cttttctaag aataatggac tcttaaggca ttgagggctc taaacaggat     1920

tctttaatca tggagcaaga gaatttcaag gcaggggatt ttatccccca ccaaaaacac     1980

agtgaaaggc ctgcttttgt gtcccattca catgccctcg gtcactgagt ctggagtgaa     2040

ccacgggttg aggaagtcag gctgttggcg tgtcccagca ccacaccacc cctaaagtgc     2100

caggtgatct cctgtggctc atcggtggaa gcagtggggt aggctgctgc cctgctgtgg     2160

aagaggagca acaatcagac atgagtccac cctttggaga ccaggcctca gctcttggtg     2220

ggcccaggga cacccacaca ggtggccatc acagccccat ggacaacact aattgtccac     2280

agcaaagggc aaggaatcct ctgggagctt cttccgtttc ttccccccag atacccatct     2340

tgaaaaacac tatttctgga atgcttctgc atcaaaggag attctttgag atagcccatc     2400

ttcctgagct agcaaataca ggagttttca ctttctttag gaaagagaag ctttcagggg     2460

aaggagagaa tgattttgct gacttcccaa gccctggtga ccagaccaag gcagggccca     2520

gcataattcc tccagttgga tgaacattca agagagctcg ttcctacctg gctggagacc     2580

gaggccagaa ggcaaaaacc agaaagggaa cagtccataa cttacctctg cttctgaccg     2640

atggtgtttg ggaataggtt actttggact gagtttgggt tctctgctgt cctaagaact     2700

tcagtgtaga gaaaataaga cttctggtgc tgctggggta tgttctgggc ttaattcccc     2760

caagcagaag accagatcca agatgtttgg acaccctgtc agacgttggt cccaagttta     2820

attagatttc tgaatctcgt tgaggccaag gaatgatcca tactgaaaaa atgctgagcc     2880

agccatcttt ggcaaaggtc cctgagctct tgctatctct caagagtgct gagaaccacg     2940

gtgaaagtgc tgctctaggc ccacaagtgt aactatgctg ttaacagctg tcaatagata     3000

attaaaattc atactgtatg aaaatca                                         3027


<210>  19
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Leu Leu Lys Val Lys Phe Asp Gln Lys Lys Arg Val Lys Leu 
1               5                   10                  15      


Ala Gln Gly Leu Trp Leu Met Asn Trp Phe Ser Val Leu Ala Gly Ile 
            20                  25                  30          


Ile Ile Phe Ser Leu Gly Leu Phe Leu Lys Ile Glu Leu Arg Lys Arg 
        35                  40                  45              


Ser Asp Val Met Asn Asn Ser Glu Ser His Phe Val Pro Asn Ser Leu 
    50                  55                  60                  


Ile Gly Met Gly Val Leu Ser Cys Val Phe Asn Ser Leu Ala Gly Lys 
65                  70                  75                  80  


Ile Cys Tyr Asp Ala Leu Asp Pro Ala Lys Tyr Ala Arg Trp Lys Pro 
                85                  90                  95      


Trp Leu Lys Pro Tyr Leu Ala Ile Cys Val Leu Phe Asn Ile Ile Leu 
            100                 105                 110         


Phe Leu Val Ala Leu Cys Cys Phe Leu Leu Arg Gly Ser Leu Glu Asn 
        115                 120                 125             


Thr Leu Gly Gln Gly Leu Lys Asn Gly Met Lys Tyr Tyr Arg Asp Thr 
    130                 135                 140                 


Asp Thr Pro Gly Arg Cys Phe Met Lys Lys Thr Ile Asp Met Leu Gln 
145                 150                 155                 160 


Ile Glu Phe Lys Cys Cys Gly Asn Asn Gly Phe Arg Asp Trp Phe Glu 
                165                 170                 175     


Ile Gln Trp Ile Ser Asn Arg Tyr Leu Asp Phe Ser Ser Lys Glu Val 
            180                 185                 190         


Lys Asp Arg Ile Lys Ser Asn Val Asp Gly Arg Tyr Leu Val Asp Gly 
        195                 200                 205             


Val Pro Phe Ser Cys Cys Asn Pro Ser Ser Pro Arg Pro Cys Ile Gln 
    210                 215                 220                 


Tyr Gln Ile Thr Asn Asn Ser Ala His Tyr Ser Tyr Asp His Gln Thr 
225                 230                 235                 240 


Glu Glu Leu Asn Leu Trp Val Arg Gly Cys Arg Ala Ala Leu Leu Ser 
                245                 250                 255     


Tyr Tyr Ser Ser Leu Met Asn Ser Met Gly Val Val Thr Leu Leu Ile 
            260                 265                 270         


Trp Leu Phe Glu Val Thr Ile Thr Ile Gly Leu Arg Tyr Leu Gln Thr 
        275                 280                 285             


Ser Leu Asp Gly Val Ser Asn Pro Glu Glu Ser Glu Ser Glu Ser Gln 
    290                 295                 300                 


Gly Trp Leu Leu Glu Arg Ser Val Pro Glu Thr Trp Lys Ala Phe Leu 
305                 310                 315                 320 


Glu Ser Val Lys Lys Leu Gly Lys Gly Asn Gln Val Glu Ala Glu Gly 
                325                 330                 335     


Ala Asp Ala Gly Gln Ala Pro Glu Ala Gly 
            340                 345     


<210>  20
<211>  1767
<212>  DNA
<213>  Homo sapiens

<400>  20
gtcagctggg tgactcatac atctgtgaga ccctccgtat ggagaccggg gcggggggtg       60

ttgcttaatg cttagaactg ctgaaactac cagttcactg tctcagcact aatccaactc      120

tgctccttaa gtgggatttg gcttttagac attgagacct ggatgctggg catcctcgct      180

agatccccta caaattcccc acatacgtag gccaggagcc tcagcggtgc cccttcaggc      240

tcatctggca agacggtacc agcttgctca gaacaggggc tggctattca tcatctcaga      300

gcatagagac cctctccttg ccacccggcc cttcccacct ggttggtgac aaatcacaag      360

gtggtagaag ttgccaggga cagataacat ggcagccagc gggaagacca gcaagtccga      420

accgaaccat gttatcttca agaagatctc ccgggacaaa tcggtgacca tctacctggg      480

gaacagagac tacatagacc atgtcagcca agtccagcct gtggatggtg tcgtgttggt      540

tgatcctgat cttgtgaagg gaaagaaagt gtatgtcact ctgacctgcg ccttccgcta      600

tggccaagag gacattgacg tgatcggctt gaccttccgc agggacctgt acttctcccg      660

ggtccaggtg tatcctcctg tgggggccgc gagcaccccc acaaaactgc aagagagcct      720

gcttaaaaag ctggggagca acacgtaccc ctttctcctg acgtttcctg actacttgcc      780

ctgttcagtg atgttgcagc cagctccaca agattcaggg aagtcctgtg gggttgactt      840

tgaggtcaaa gcattcgcca cagacagcac cgatgccgaa gaggacaaaa tccccaagaa      900

gagctccgtg cgattactga tccgcaaagt acagcatgcc ccacttgaga tgggtcccca      960

gccccgagct gaggcggcct ggcagttctt catgtctgac aagcccctgc accttgcggt     1020

ctctctcaac aaagagatct atttccatgg ggagcccatc cctgtgaccg tgactgtcac     1080

caataacaca gagaagaccg tgaagaagat taaagcattc gtggaacagg tggccaatgt     1140

ggttctctac tcgagtgatt attacgtcaa gcccgtggct atggaggaag cgcaagaaaa     1200

agtgccacca aacagcactt tgaccaagac gctgacgctg ctgcccttgc tggctaacaa     1260

tcgagaaagg agaggcattg ccctggatgg gaaaatcaag cacgaggaca caaaccttgc     1320

ctccagcacc atcattaagg agggcataga ccggaccgtc ctgggaatcc tggtgtctta     1380

ccagatcaag gtgaagctca cagtgtcagg ctttctggga gagctcacct ccagtgaagt     1440

cgccactgag gtcccattcc gcctcatgca ccctcagcct gaggacccag ctaaggaaag     1500

ttatcaggat gcaaatttag tttttgagga gtttgctcgc cataatctga aagatgcagg     1560

agaagctgag gaggggaaga gagacaagaa tgacgttgat gagtgaagat gtcggctcag     1620

gatgccggaa aatgacctgt agttaccagt gcaacgagca aagccccaca gtttagtcct     1680

ttggagttat gctgcgtatg aaaggatgag tcttcttccg agaaataaag cttgtttgtt     1740

ctcccctgga aaaaaaaaaa aaaaaaa                                         1767


<210>  21
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Ala Ser Gly Lys Thr Ser Lys Ser Glu Pro Asn His Val Ile 
1               5                   10                  15      


Phe Lys Lys Ile Ser Arg Asp Lys Ser Val Thr Ile Tyr Leu Gly Asn 
            20                  25                  30          


Arg Asp Tyr Ile Asp His Val Ser Gln Val Gln Pro Val Asp Gly Val 
        35                  40                  45              


Val Leu Val Asp Pro Asp Leu Val Lys Gly Lys Lys Val Tyr Val Thr 
    50                  55                  60                  


Leu Thr Cys Ala Phe Arg Tyr Gly Gln Glu Asp Ile Asp Val Ile Gly 
65                  70                  75                  80  


Leu Thr Phe Arg Arg Asp Leu Tyr Phe Ser Arg Val Gln Val Tyr Pro 
                85                  90                  95      


Pro Val Gly Ala Ala Ser Thr Pro Thr Lys Leu Gln Glu Ser Leu Leu 
            100                 105                 110         


Lys Lys Leu Gly Ser Asn Thr Tyr Pro Phe Leu Leu Thr Phe Pro Asp 
        115                 120                 125             


Tyr Leu Pro Cys Ser Val Met Leu Gln Pro Ala Pro Gln Asp Ser Gly 
    130                 135                 140                 


Lys Ser Cys Gly Val Asp Phe Glu Val Lys Ala Phe Ala Thr Asp Ser 
145                 150                 155                 160 


Thr Asp Ala Glu Glu Asp Lys Ile Pro Lys Lys Ser Ser Val Arg Leu 
                165                 170                 175     


Leu Ile Arg Lys Val Gln His Ala Pro Leu Glu Met Gly Pro Gln Pro 
            180                 185                 190         


Arg Ala Glu Ala Ala Trp Gln Phe Phe Met Ser Asp Lys Pro Leu His 
        195                 200                 205             


Leu Ala Val Ser Leu Asn Lys Glu Ile Tyr Phe His Gly Glu Pro Ile 
    210                 215                 220                 


Pro Val Thr Val Thr Val Thr Asn Asn Thr Glu Lys Thr Val Lys Lys 
225                 230                 235                 240 


Ile Lys Ala Phe Val Glu Gln Val Ala Asn Val Val Leu Tyr Ser Ser 
                245                 250                 255     


Asp Tyr Tyr Val Lys Pro Val Ala Met Glu Glu Ala Gln Glu Lys Val 
            260                 265                 270         


Pro Pro Asn Ser Thr Leu Thr Lys Thr Leu Thr Leu Leu Pro Leu Leu 
        275                 280                 285             


Ala Asn Asn Arg Glu Arg Arg Gly Ile Ala Leu Asp Gly Lys Ile Lys 
    290                 295                 300                 


His Glu Asp Thr Asn Leu Ala Ser Ser Thr Ile Ile Lys Glu Gly Ile 
305                 310                 315                 320 


Asp Arg Thr Val Leu Gly Ile Leu Val Ser Tyr Gln Ile Lys Val Lys 
                325                 330                 335     


Leu Thr Val Ser Gly Phe Leu Gly Glu Leu Thr Ser Ser Glu Val Ala 
            340                 345                 350         


Thr Glu Val Pro Phe Arg Leu Met His Pro Gln Pro Glu Asp Pro Ala 
        355                 360                 365             


Lys Glu Ser Tyr Gln Asp Ala Asn Leu Val Phe Glu Glu Phe Ala Arg 
    370                 375                 380                 


His Asn Leu Lys Asp Ala Gly Glu Ala Glu Glu Gly Lys Arg Asp Lys 
385                 390                 395                 400 


Asn Asp Val Asp Glu 
                405 


<210>  22
<211>  2483
<212>  DNA
<213>  Homo sapiens

<400>  22
agttgattgc aggtcctcct ggggccagaa gggtgcctgg gaggccaggt tctggggatc       60

ccctccatcc agaagaacca cctgctcact ctgtcccttc gcctgctgct gggaccatgg      120

gggctggggc cagtgctgag gagaagcact ccagggagct ggaaaagaag ctgaaagagg      180

acgctgagaa ggatgctcga accgtgaagc tgctgcttct gggtgccggt gagtccggga      240

agagcaccat cgtcaagcag atgaagatta tccaccagga cgggtactcg ctggaagagt      300

gcctcgagtt tatcgccatc atctacggca acacgttgca gtccatcctg gccatcgtac      360

gcgccatgac cacactcaac atccagtacg gagactctgc acgccaggac gacgcccgga      420

agctgatgca catggcagac actatcgagg agggcacgat gcccaaggag atgtcggaca      480

tcatccagcg gctgtggaag gactccggta tccaggcctg ttttgagcgc gcctcggagt      540

accagctcaa cgactcggcg ggctactacc tctccgacct ggagcgcctg gtaaccccgg      600

gctacgtgcc caccgagcag gacgtgctgc gctcgcgagt caagaccact ggcatcatcg      660

agacgcagtt ctccttcaag gatctcaact tccggatgtt cgatgtgggc gggcagcgct      720

cggagcgcaa gaagtggatc cactgcttcg agggcgtgac ctgcatcatc ttcatcgcgg      780

cgctgagcgc ctacgacatg gtgctagtgg aggacgacga agtgaaccgc atgcacgaga      840

gcctgcacct gttcaacagc atctgcaacc accgctactt cgccacgacg tccatcgtgc      900

tcttccttaa caagaaggac gtcttcttcg agaagatcaa gaaggcgcac ctcagcatct      960

gtttcccgga ctacgatgga cccaacacct acgaggacgc cggcaactac atcaaggtgc     1020

agttcctcga gctcaacatg cggcgcgacg tgaaggagat ctattcccac atgacgtgcg     1080

ccaccgacac gcagaacgtc aaatttgtct tcgacgctgt caccgacatc atcatcaagg     1140

agaacctcaa agactgtggc ctcttctgag gccagggcct gtgctgcagt cggggacaag     1200

gagcttccgt ctggcaaggc cggggcacaa tttgcactcc cctcagctag acgcacagac     1260

tcagcaataa acctttgcat caggctccag ctgtcctttc ttggtggagg acttaattat     1320

cacaagtcat gggcatttat taagtgccca gtgctgggtt gggcatgaag tgggaagatg     1380

gcccctccca ggaagaagta cctggcctga caaggtgggg cactcttggg ggtatgggac     1440

caactcatgg cttttcacgg gagttgagga gagaggagct gtggaaaata ttcactggga     1500

cagtcttgga tcaagaggga gttttgaggt ggaggctcat tctggcaggg accgtagtgt     1560

ctaccagccc cagaaacatg ggcttatggc cacaggagtt cagtggagca agagcagggg     1620

aggagagacg tggacaggtg cccaaagcca gtcggagggc ctgggctttc tcagaaggtg     1680

atggagagtc ttggaagccc tcgaggcagg aacataattg cagggctggg attagggtga     1740

gggaagtgag gcacactcac cttgggtgca acatttaagg cgatgccaaa aaatttagta     1800

accaaggtaa ataatattag gataatattt ttaaaaatca aatgaatgca aaaccccaca     1860

atgaatgaaa tatcaaaatc caacagagga tcaaacagag gcatgctaag atatattggg     1920

gcttgaagca aagggaaaac tatttgttgc tatatgtttg tagggatttt ttgccagttt     1980

taaaaataca tgtatcataa agtttactat ctcagccact tgccggtgta tagtttggtg     2040

gtgttaagta cattcataat gttgtacaac caccgcaact gttcatctcc agaactcctt     2100

tcctcttgta aaactgtaac tctgtaccca tgaaaaaata accccccatt cctgccttcc     2160

cccggctcct ggcatccacc attctacttt ccatctctat gaatgtgact gctctaagtg     2220

cctcagatgt gtgggtccat gaagtctttg tctttttgca actggcttat ttcacttagc     2280

atcatgtctt caaggtttat tcatgtgtag catatggcag aatctccttc ctttttaagg     2340

ttgaataata ttccattgta tatattccac actttgttta tttattcatc tattgatgaa     2400

tggttacatc tgccttttgg ctattgtgaa taatgctgct atgaacatgg gtgtacaaat     2460

ctctcaaaaa aaaaaaaaaa aaa                                             2483


<210>  23
<211>  350
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Gly Ala Gly Ala Ser Ala Glu Glu Lys His Ser Arg Glu Leu Glu 
1               5                   10                  15      


Lys Lys Leu Lys Glu Asp Ala Glu Lys Asp Ala Arg Thr Val Lys Leu 
            20                  25                  30          


Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr Ile Val Lys Gln 
        35                  40                  45              


Met Lys Ile Ile His Gln Asp Gly Tyr Ser Leu Glu Glu Cys Leu Glu 
    50                  55                  60                  


Phe Ile Ala Ile Ile Tyr Gly Asn Thr Leu Gln Ser Ile Leu Ala Ile 
65                  70                  75                  80  


Val Arg Ala Met Thr Thr Leu Asn Ile Gln Tyr Gly Asp Ser Ala Arg 
                85                  90                  95      


Gln Asp Asp Ala Arg Lys Leu Met His Met Ala Asp Thr Ile Glu Glu 
            100                 105                 110         


Gly Thr Met Pro Lys Glu Met Ser Asp Ile Ile Gln Arg Leu Trp Lys 
        115                 120                 125             


Asp Ser Gly Ile Gln Ala Cys Phe Glu Arg Ala Ser Glu Tyr Gln Leu 
    130                 135                 140                 


Asn Asp Ser Ala Gly Tyr Tyr Leu Ser Asp Leu Glu Arg Leu Val Thr 
145                 150                 155                 160 


Pro Gly Tyr Val Pro Thr Glu Gln Asp Val Leu Arg Ser Arg Val Lys 
                165                 170                 175     


Thr Thr Gly Ile Ile Glu Thr Gln Phe Ser Phe Lys Asp Leu Asn Phe 
            180                 185                 190         


Arg Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg Lys Lys Trp Ile 
        195                 200                 205             


His Cys Phe Glu Gly Val Thr Cys Ile Ile Phe Ile Ala Ala Leu Ser 
    210                 215                 220                 


Ala Tyr Asp Met Val Leu Val Glu Asp Asp Glu Val Asn Arg Met His 
225                 230                 235                 240 


Glu Ser Leu His Leu Phe Asn Ser Ile Cys Asn His Arg Tyr Phe Ala 
                245                 250                 255     


Thr Thr Ser Ile Val Leu Phe Leu Asn Lys Lys Asp Val Phe Phe Glu 
            260                 265                 270         


Lys Ile Lys Lys Ala His Leu Ser Ile Cys Phe Pro Asp Tyr Asp Gly 
        275                 280                 285             


Pro Asn Thr Tyr Glu Asp Ala Gly Asn Tyr Ile Lys Val Gln Phe Leu 
    290                 295                 300                 


Glu Leu Asn Met Arg Arg Asp Val Lys Glu Ile Tyr Ser His Met Thr 
305                 310                 315                 320 


Cys Ala Thr Asp Thr Gln Asn Val Lys Phe Val Phe Asp Ala Val Thr 
                325                 330                 335     


Asp Ile Ile Ile Lys Glu Asn Leu Lys Asp Cys Gly Leu Phe 
            340                 345                 350 


<210>  24
<211>  201
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Gly Asn Val Met Glu Gly Lys Ser Val Glu Glu Leu Ser Ser Thr 
1               5                   10                  15      


Glu Cys His Gln Trp Tyr Lys Lys Phe Met Thr Glu Cys Pro Ser Gly 
            20                  25                  30          


Gln Leu Thr Leu Tyr Glu Phe Arg Gln Phe Phe Gly Leu Lys Asn Leu 
        35                  40                  45              


Ser Pro Ser Ala Ser Gln Tyr Val Glu Gln Met Phe Glu Thr Phe Asp 
    50                  55                  60                  


Phe Asn Lys Asp Gly Tyr Ile Asp Phe Met Glu Tyr Val Ala Ala Leu 
65                  70                  75                  80  


Ser Leu Val Leu Lys Gly Lys Val Glu Gln Lys Leu Arg Trp Tyr Phe 
                85                  90                  95      


Lys Leu Tyr Asp Val Asp Gly Asn Gly Cys Ile Asp Arg Asp Glu Leu 
            100                 105                 110         


Leu Thr Ile Ile Gln Ala Ile Arg Ala Ile Asn Pro Cys Ser Asp Thr 
        115                 120                 125             


Thr Met Thr Ala Glu Glu Phe Thr Asp Thr Val Phe Ser Lys Ile Asp 
    130                 135                 140                 


Val Asn Gly Asp Gly Glu Leu Ser Leu Glu Glu Phe Ile Glu Gly Val 
145                 150                 155                 160 


Gln Lys Asp Gln Met Leu Leu Asp Thr Leu Thr Arg Ser Leu Asp Leu 
                165                 170                 175     


Thr Arg Ile Val Arg Arg Leu Gln Asn Gly Glu Gln Asp Glu Glu Gly 
            180                 185                 190         


Ala Asp Glu Ala Ala Glu Ala Ala Gly 
        195                 200     


<210>  25
<211>  1103
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Thr Ala Cys Ala Arg Arg Ala Gly Gly Leu Pro Asp Pro Gly Leu 
1               5                   10                  15      


Cys Gly Pro Ala Trp Trp Ala Pro Ser Leu Pro Arg Leu Pro Arg Ala 
            20                  25                  30          


Leu Pro Arg Leu Pro Leu Leu Leu Leu Leu Leu Leu Leu Gln Pro Pro 
        35                  40                  45              


Ala Leu Ser Ala Val Phe Thr Val Gly Val Leu Gly Pro Trp Ala Cys 
    50                  55                  60                  


Asp Pro Ile Phe Ser Arg Ala Arg Pro Asp Leu Ala Ala Arg Leu Ala 
65                  70                  75                  80  


Ala Ala Arg Leu Asn Arg Asp Pro Gly Leu Ala Gly Gly Pro Arg Phe 
                85                  90                  95      


Glu Val Ala Leu Leu Pro Glu Pro Cys Arg Thr Pro Gly Ser Leu Gly 
            100                 105                 110         


Ala Val Ser Ser Ala Leu Ala Arg Val Ser Gly Leu Val Gly Pro Val 
        115                 120                 125             


Asn Pro Ala Ala Cys Arg Pro Ala Glu Leu Leu Ala Glu Glu Ala Gly 
    130                 135                 140                 


Ile Ala Leu Val Pro Trp Gly Cys Pro Trp Thr Gln Ala Glu Gly Thr 
145                 150                 155                 160 


Thr Ala Pro Ala Val Thr Pro Ala Ala Asp Ala Leu Tyr Ala Leu Leu 
                165                 170                 175     


Arg Ala Phe Gly Trp Ala Arg Val Ala Leu Val Thr Ala Pro Gln Asp 
            180                 185                 190         


Leu Trp Val Glu Ala Gly Arg Ser Leu Ser Thr Ala Leu Arg Ala Arg 
        195                 200                 205             


Gly Leu Pro Val Ala Ser Val Thr Ser Met Glu Pro Leu Asp Leu Ser 
    210                 215                 220                 


Gly Ala Arg Glu Ala Leu Arg Lys Val Arg Asp Gly Pro Arg Val Thr 
225                 230                 235                 240 


Ala Val Ile Met Val Met His Ser Val Leu Leu Gly Gly Glu Glu Gln 
                245                 250                 255     


Arg Tyr Leu Leu Glu Ala Ala Glu Glu Leu Gly Leu Thr Asp Gly Ser 
            260                 265                 270         


Leu Val Phe Leu Pro Phe Asp Thr Ile His Tyr Ala Leu Ser Pro Gly 
        275                 280                 285             


Pro Glu Ala Leu Ala Ala Leu Ala Asn Ser Ser Gln Leu Arg Arg Ala 
    290                 295                 300                 


His Asp Ala Val Leu Thr Leu Thr Arg His Cys Pro Ser Glu Gly Ser 
305                 310                 315                 320 


Val Leu Asp Ser Leu Arg Arg Ala Gln Glu Arg Arg Glu Leu Pro Ser 
                325                 330                 335     


Asp Leu Asn Leu Gln Gln Val Ser Pro Leu Phe Gly Thr Ile Tyr Asp 
            340                 345                 350         


Ala Val Phe Leu Leu Ala Arg Gly Val Ala Glu Ala Arg Ala Ala Ala 
        355                 360                 365             


Gly Gly Arg Trp Val Ser Gly Ala Ala Val Ala Arg His Ile Arg Asp 
    370                 375                 380                 


Ala Gln Val Pro Gly Phe Cys Gly Asp Leu Gly Gly Asp Glu Glu Pro 
385                 390                 395                 400 


Pro Phe Val Leu Leu Asp Thr Asp Ala Ala Gly Asp Arg Leu Phe Ala 
                405                 410                 415     


Thr Tyr Met Leu Asp Pro Ala Arg Gly Ser Phe Leu Ser Ala Gly Thr 
            420                 425                 430         


Arg Met His Phe Pro Arg Gly Gly Ser Ala Pro Gly Pro Asp Pro Ser 
        435                 440                 445             


Cys Trp Phe Asp Pro Asn Asn Ile Cys Gly Gly Gly Leu Glu Pro Gly 
    450                 455                 460                 


Leu Val Phe Leu Gly Phe Leu Leu Val Val Gly Met Gly Leu Ala Gly 
465                 470                 475                 480 


Ala Phe Leu Ala His Tyr Val Arg His Arg Leu Leu His Met Gln Met 
                485                 490                 495     


Val Ser Gly Pro Asn Lys Ile Ile Leu Thr Val Asp Asp Ile Thr Phe 
            500                 505                 510         


Leu His Pro His Gly Gly Thr Ser Arg Lys Val Ala Gln Gly Ser Arg 
        515                 520                 525             


Ser Ser Leu Gly Ala Arg Ser Met Ser Asp Ile Arg Ser Gly Pro Ser 
    530                 535                 540                 


Gln His Leu Asp Ser Pro Asn Ile Gly Val Tyr Glu Gly Asp Arg Val 
545                 550                 555                 560 


Trp Leu Lys Lys Phe Pro Gly Asp Gln His Ile Ala Ile Arg Pro Ala 
                565                 570                 575     


Thr Lys Thr Ala Phe Ser Lys Leu Gln Glu Leu Arg His Glu Asn Val 
            580                 585                 590         


Ala Leu Tyr Leu Gly Leu Phe Leu Ala Arg Gly Ala Glu Gly Pro Ala 
        595                 600                 605             


Ala Leu Trp Glu Gly Asn Leu Ala Val Val Ser Glu His Cys Thr Arg 
    610                 615                 620                 


Gly Ser Leu Gln Asp Leu Leu Ala Gln Arg Glu Ile Lys Leu Asp Trp 
625                 630                 635                 640 


Met Phe Lys Ser Ser Leu Leu Leu Asp Leu Ile Lys Gly Ile Arg Tyr 
                645                 650                 655     


Leu His His Arg Gly Val Ala His Gly Arg Leu Lys Ser Arg Asn Cys 
            660                 665                 670         


Ile Val Asp Gly Arg Phe Val Leu Lys Ile Thr Asp His Gly His Gly 
        675                 680                 685             


Arg Leu Leu Glu Ala Gln Lys Val Leu Pro Glu Pro Pro Arg Ala Glu 
    690                 695                 700                 


Asp Gln Leu Trp Thr Ala Pro Glu Leu Leu Arg Asp Pro Ala Leu Glu 
705                 710                 715                 720 


Arg Arg Gly Thr Leu Ala Gly Asp Val Phe Ser Leu Ala Ile Ile Met 
                725                 730                 735     


Gln Glu Val Val Cys Arg Ser Ala Pro Tyr Ala Met Leu Glu Leu Thr 
            740                 745                 750         


Pro Glu Glu Val Val Gln Arg Val Arg Ser Pro Pro Pro Leu Cys Arg 
        755                 760                 765             


Pro Leu Val Ser Met Asp Gln Ala Pro Val Glu Cys Ile Leu Leu Met 
    770                 775                 780                 


Lys Gln Cys Trp Ala Glu Gln Pro Glu Leu Arg Pro Ser Met Asp His 
785                 790                 795                 800 


Thr Phe Asp Leu Phe Lys Asn Ile Asn Lys Gly Arg Lys Thr Asn Ile 
                805                 810                 815     


Ile Asp Ser Met Leu Arg Met Leu Glu Gln Tyr Ser Ser Asn Leu Glu 
            820                 825                 830         


Asp Leu Ile Arg Glu Arg Thr Glu Glu Leu Glu Leu Glu Lys Gln Lys 
        835                 840                 845             


Thr Asp Arg Leu Leu Thr Gln Met Leu Pro Pro Ser Val Ala Glu Ala 
    850                 855                 860                 


Leu Lys Thr Gly Thr Pro Val Glu Pro Glu Tyr Phe Glu Gln Val Thr 
865                 870                 875                 880 


Leu Tyr Phe Ser Asp Ile Val Gly Phe Thr Thr Ile Ser Ala Met Ser 
                885                 890                 895     


Glu Pro Ile Glu Val Val Asp Leu Leu Asn Asp Leu Tyr Thr Leu Phe 
            900                 905                 910         


Asp Ala Ile Ile Gly Ser His Asp Val Tyr Lys Val Glu Thr Ile Gly 
        915                 920                 925             


Asp Ala Tyr Met Val Ala Ser Gly Leu Pro Gln Arg Asn Gly Gln Arg 
    930                 935                 940                 


His Ala Ala Glu Ile Ala Asn Met Ser Leu Asp Ile Leu Ser Ala Val 
945                 950                 955                 960 


Gly Thr Phe Arg Met Arg His Met Pro Glu Val Pro Val Arg Ile Arg 
                965                 970                 975     


Ile Gly Leu His Ser Gly Pro Cys Val Ala Gly Val Val Gly Leu Thr 
            980                 985                 990         


Met Pro Arg Tyr Cys Leu Phe Gly  Asp Thr Val Asn Thr  Ala Ser Arg 
        995                 1000                 1005             


Met Glu  Ser Thr Gly Leu Pro  Tyr Arg Ile His Val  Asn Leu Ser 
    1010                 1015                 1020             


Thr Val  Gly Ile Leu Arg Ala  Leu Asp Ser Gly Tyr  Gln Val Glu 
    1025                 1030                 1035             


Leu Arg  Gly Arg Thr Glu Leu  Lys Gly Lys Gly Ala  Glu Asp Thr 
    1040                 1045                 1050             


Phe Trp  Leu Val Gly Arg Arg  Gly Phe Asn Lys Pro  Ile Pro Lys 
    1055                 1060                 1065             


Pro Pro  Asp Leu Gln Pro Gly  Ser Ser Asn His Gly  Ile Ser Leu 
    1070                 1075                 1080             


Gln Glu  Ile Pro Pro Glu Arg  Arg Arg Lys Leu Glu  Lys Ala Arg 
    1085                 1090                 1095             


Pro Gly  Gln Phe Ser 
    1100             


<210>  26
<211>  676
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Lys Ile Asn Thr Gln Tyr Ser His Pro Ser Arg Thr His Leu 
1               5                   10                  15      


Lys Val Lys Thr Ser Asp Arg Asp Leu Asn Arg Ala Glu Asn Gly Leu 
            20                  25                  30          


Ser Arg Ala His Ser Ser Ser Glu Glu Thr Ser Ser Val Leu Gln Pro 
        35                  40                  45              


Gly Ile Ala Met Glu Thr Arg Gly Leu Ala Asp Ser Gly Gln Gly Ser 
    50                  55                  60                  


Phe Thr Gly Gln Gly Ile Ala Arg Leu Ser Arg Leu Ile Phe Leu Leu 
65                  70                  75                  80  


Arg Arg Trp Ala Ala Arg His Val His His Gln Asp Gln Gly Pro Asp 
                85                  90                  95      


Ser Phe Pro Asp Arg Phe Arg Gly Ala Glu Leu Lys Glu Val Ser Ser 
            100                 105                 110         


Gln Glu Ser Asn Ala Gln Ala Asn Val Gly Ser Gln Glu Pro Ala Asp 
        115                 120                 125             


Arg Gly Arg Arg Lys Lys Thr Lys Lys Lys Asp Ala Ile Val Val Asp 
    130                 135                 140                 


Pro Ser Ser Asn Leu Tyr Tyr Arg Trp Leu Thr Ala Ile Ala Leu Pro 
145                 150                 155                 160 


Val Phe Tyr Asn Trp Tyr Leu Leu Ile Cys Arg Ala Cys Phe Asp Glu 
                165                 170                 175     


Leu Gln Ser Glu Tyr Leu Met Leu Trp Leu Val Leu Asp Tyr Ser Ala 
            180                 185                 190         


Asp Val Leu Tyr Val Leu Asp Val Leu Val Arg Ala Arg Thr Gly Phe 
        195                 200                 205             


Leu Glu Gln Gly Leu Met Val Ser Asp Thr Asn Arg Leu Trp Gln His 
    210                 215                 220                 


Tyr Lys Thr Thr Thr Gln Phe Lys Leu Asp Val Leu Ser Leu Val Pro 
225                 230                 235                 240 


Thr Asp Leu Ala Tyr Leu Lys Val Gly Thr Asn Tyr Pro Glu Val Arg 
                245                 250                 255     


Phe Asn Arg Leu Leu Lys Phe Ser Arg Leu Phe Glu Phe Phe Asp Arg 
            260                 265                 270         


Thr Glu Thr Arg Thr Asn Tyr Pro Asn Met Phe Arg Ile Gly Asn Leu 
        275                 280                 285             


Val Leu Tyr Ile Leu Ile Ile Ile His Trp Asn Ala Cys Ile Tyr Phe 
    290                 295                 300                 


Ala Ile Ser Lys Phe Ile Gly Phe Gly Thr Asp Ser Trp Val Tyr Pro 
305                 310                 315                 320 


Asn Ile Ser Ile Pro Glu His Gly Arg Leu Ser Arg Lys Tyr Ile Tyr 
                325                 330                 335     


Ser Leu Tyr Trp Ser Thr Leu Thr Leu Thr Thr Ile Gly Glu Thr Pro 
            340                 345                 350         


Pro Pro Val Lys Asp Glu Glu Tyr Leu Phe Val Val Val Asp Phe Leu 
        355                 360                 365             


Val Gly Val Leu Ile Phe Ala Thr Ile Val Gly Asn Val Gly Ser Met 
    370                 375                 380                 


Ile Ser Asn Met Asn Ala Ser Arg Ala Glu Phe Gln Ala Lys Ile Asp 
385                 390                 395                 400 


Ser Ile Lys Gln Tyr Met Gln Phe Arg Lys Val Thr Lys Asp Leu Glu 
                405                 410                 415     


Thr Arg Val Ile Arg Trp Phe Asp Tyr Leu Trp Ala Asn Lys Lys Thr 
            420                 425                 430         


Val Asp Glu Lys Glu Val Leu Lys Ser Leu Pro Asp Lys Leu Lys Ala 
        435                 440                 445             


Glu Ile Ala Ile Asn Val His Leu Asp Thr Leu Lys Lys Val Arg Ile 
    450                 455                 460                 


Phe Gln Asp Cys Glu Ala Gly Leu Leu Val Glu Leu Val Leu Lys Leu 
465                 470                 475                 480 


Arg Pro Thr Val Phe Ser Pro Gly Asp Tyr Ile Cys Lys Lys Gly Asp 
                485                 490                 495     


Ile Gly Lys Glu Met Tyr Ile Ile Asn Glu Gly Lys Leu Ala Val Val 
            500                 505                 510         


Ala Asp Asp Gly Val Thr Gln Phe Val Val Leu Ser Asp Gly Ser Tyr 
        515                 520                 525             


Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser Lys Ser Gly Asn 
    530                 535                 540                 


Arg Arg Thr Ala Asn Ile Arg Ser Ile Gly Tyr Ser Asp Leu Phe Cys 
545                 550                 555                 560 


Leu Ser Lys Asp Asp Leu Met Glu Ala Leu Thr Glu Tyr Pro Glu Ala 
                565                 570                 575     


Lys Lys Ala Leu Glu Glu Lys Gly Arg Gln Ile Leu Met Lys Asp Asn 
            580                 585                 590         


Leu Ile Asp Glu Glu Leu Ala Arg Ala Gly Ala Asp Pro Lys Asp Leu 
        595                 600                 605             


Glu Glu Lys Val Glu Gln Leu Gly Ser Ser Leu Asp Thr Leu Gln Thr 
    610                 615                 620                 


Arg Phe Ala Arg Leu Leu Ala Glu Tyr Asn Ala Thr Gln Met Lys Met 
625                 630                 635                 640 


Lys Gln Arg Leu Ser Gln Leu Glu Ser Gln Val Lys Gly Gly Gly Asp 
                645                 650                 655     


Lys Pro Leu Ala Asp Gly Glu Val Pro Gly Asp Ala Thr Lys Thr Glu 
            660                 665                 670         


Asp Lys Gln Gln 
        675     


<210>  27
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Lys Ile Asn Thr Gln Tyr Ser His Pro Ser Arg Thr His Leu 
1               5                   10                  15      


Lys Val Lys Thr Ser Asp Arg Asp Leu Asn Arg Ala Glu Asn Gly Leu 
            20                  25                  30          


Ser Arg Ala His Ser Ser Ser Glu Glu Thr Ser Ser Val Leu Gln Pro 
        35                  40                  45              


Gly Ile Ala Met Glu Thr Arg Gly Leu Ala Asp Ser Gly Gln Gly Ser 
    50                  55                  60                  


Phe Thr Gly Gln Gly Ile Ala Arg Leu Ser Arg Leu Ile Phe Leu Leu 
65                  70                  75                  80  


Arg Arg Trp Ala Ala Arg His Val His His Gln Asp Gln Gly Pro Asp 
                85                  90                  95      


Ser Phe Pro Asp Arg Phe Arg Gly Ala Glu Leu Lys Glu Val Ser Ser 
            100                 105                 110         


Gln Glu Ser Asn Ala Gln Ala Asn Val Gly Ser Gln Glu Pro Ala Asp 
        115                 120                 125             


Arg Gly Arg Ser Ala Trp Pro Leu Ala Lys Cys Asn Thr Asn Thr Ser 
    130                 135                 140                 


Asn Asn Thr Glu Glu Glu Lys Lys Thr Lys Lys Lys Asp Ala Ile Val 
145                 150                 155                 160 


Val Asp Pro Ser Ser Asn Leu Tyr Tyr Arg Trp Leu Thr Ala Ile Ala 
                165                 170                 175     


Leu Pro Val Phe Tyr Asn Trp Tyr Leu Leu Ile Cys Arg Ala Cys Phe 
            180                 185                 190         


Asp Glu Leu Gln Ser Glu Tyr Leu Met Leu Trp Leu Val Leu Asp Tyr 
        195                 200                 205             


Ser Ala Asp Val Leu Tyr Val Leu Asp Val Leu Val Arg Ala Arg Thr 
    210                 215                 220                 


Gly Phe Leu Glu Gln Gly Leu Met Val Ser Asp Thr Asn Arg Leu Trp 
225                 230                 235                 240 


Gln His Tyr Lys Thr Thr Thr Gln Phe Lys Leu Asp Val Leu Ser Leu 
                245                 250                 255     


Val Pro Thr Asp Leu Ala Tyr Leu Lys Val Gly Thr Asn Tyr Pro Glu 
            260                 265                 270         


Val Arg Phe Asn Arg Leu Leu Lys Phe Ser Arg Leu Phe Glu Phe Phe 
        275                 280                 285             


Asp Arg Thr Glu Thr Arg Thr Asn Tyr Pro Asn Met Phe Arg Ile Gly 
    290                 295                 300                 


Asn Leu Val Leu Tyr Ile Leu Ile Ile Ile His Trp Asn Ala Cys Ile 
305                 310                 315                 320 


Tyr Phe Ala Ile Ser Lys Phe Ile Gly Phe Gly Thr Asp Ser Trp Val 
                325                 330                 335     


Tyr Pro Asn Ile Ser Ile Pro Glu His Gly Arg Leu Ser Arg Lys Tyr 
            340                 345                 350         


Ile Tyr Ser Leu Tyr Trp Ser Thr Leu Thr Leu Thr Thr Ile Gly Glu 
        355                 360                 365             


Thr Pro Pro Pro Val Lys Asp Glu Glu Tyr Leu Phe Val Val Val Asp 
    370                 375                 380                 


Phe Leu Val Gly Val Leu Ile Phe Ala Thr Ile Val Gly Asn Val Gly 
385                 390                 395                 400 


Ser Met Ile Ser Asn Met Asn Ala Ser Arg Ala Glu Phe Gln Ala Lys 
                405                 410                 415     


Ile Asp Ser Ile Lys Gln Tyr Met Gln Phe Arg Lys Val Thr Lys Asp 
            420                 425                 430         


Leu Glu Thr Arg Val Ile Arg Trp Phe Asp Tyr Leu Trp Ala Asn Lys 
        435                 440                 445             


Lys Thr Val Asp Glu Lys Glu Val Leu Lys Ser Leu Pro Asp Lys Leu 
    450                 455                 460                 


Lys Ala Glu Ile Ala Ile Asn Val His Leu Asp Thr Leu Lys Lys Val 
465                 470                 475                 480 


Arg Ile Phe Gln Asp Cys Glu Ala Gly Leu Leu Val Glu Leu Val Leu 
                485                 490                 495     


Lys Leu Arg Pro Thr Val Phe Ser Pro Gly Asp Tyr Ile Cys Lys Lys 
            500                 505                 510         


Gly Asp Ile Gly Lys Glu Met Tyr Ile Ile Asn Glu Gly Lys Leu Ala 
        515                 520                 525             


Val Val Ala Asp Asp Gly Val Thr Gln Phe Val Val Leu Ser Asp Gly 
    530                 535                 540                 


Ser Tyr Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser Lys Ser 
545                 550                 555                 560 


Gly Asn Arg Arg Thr Ala Asn Ile Arg Ser Ile Gly Tyr Ser Asp Leu 
                565                 570                 575     


Phe Cys Leu Ser Lys Asp Asp Leu Met Glu Ala Leu Thr Glu Tyr Pro 
            580                 585                 590         


Glu Ala Lys Lys Ala Leu Glu Glu Lys Gly Arg Gln Ile Leu Met Lys 
        595                 600                 605             


Asp Asn Leu Ile Asp Glu Glu Leu Ala Arg Ala Gly Ala Asp Pro Lys 
    610                 615                 620                 


Asp Leu Glu Glu Lys Val Glu Gln Leu Gly Ser Ser Leu Asp Thr Leu 
625                 630                 635                 640 


Gln Thr Arg Phe Ala Arg Leu Leu Ala Glu Tyr Asn Ala Thr Gln Met 
                645                 650                 655     


Lys Met Lys Gln Arg Leu Ser Gln Leu Glu Ser Gln Val Lys Gly Gly 
            660                 665                 670         


Gly Asp Lys Pro Leu Ala Asp Gly Glu Val Pro Gly Asp Ala Thr Lys 
        675                 680                 685             


Thr Glu Asp Lys Gln Gln 
    690                 


<210>  28
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Gly Ser Gly Ala Ser Ala Glu Asp Lys Glu Leu Ala Lys Arg Ser 
1               5                   10                  15      


Lys Glu Leu Glu Lys Lys Leu Gln Glu Asp Ala Asp Lys Glu Ala Lys 
            20                  25                  30          


Thr Val Lys Leu Leu Leu Leu Gly Ala Gly Glu Ser Gly Lys Ser Thr 
        35                  40                  45              


Ile Val Lys Gln Met Lys Ile Ile His Gln Asp Gly Tyr Ser Pro Glu 
    50                  55                  60                  


Glu Cys Leu Glu Phe Lys Ala Ile Ile Tyr Gly Asn Val Leu Gln Ser 
65                  70                  75                  80  


Ile Leu Ala Ile Ile Arg Ala Met Thr Thr Leu Gly Ile Asp Tyr Ala 
                85                  90                  95      


Glu Pro Ser Cys Ala Asp Asp Gly Arg Gln Leu Asn Asn Leu Ala Asp 
            100                 105                 110         


Ser Ile Glu Glu Gly Thr Met Pro Pro Glu Leu Val Glu Val Ile Arg 
        115                 120                 125             


Arg Leu Trp Lys Asp Gly Gly Val Gln Ala Cys Phe Glu Arg Ala Ala 
    130                 135                 140                 


Glu Tyr Gln Leu Asn Asp Ser Ala Ser Tyr Tyr Leu Asn Gln Leu Glu 
145                 150                 155                 160 


Arg Ile Thr Asp Pro Glu Tyr Leu Pro Ser Glu Gln Asp Val Leu Arg 
                165                 170                 175     


Ser Arg Val Lys Thr Thr Gly Ile Ile Glu Thr Lys Phe Ser Val Lys 
            180                 185                 190         


Asp Leu Asn Phe Arg Met Phe Asp Val Gly Gly Gln Arg Ser Glu Arg 
        195                 200                 205             


Lys Lys Trp Ile His Cys Phe Glu Gly Val Thr Cys Ile Ile Phe Cys 
    210                 215                 220                 


Ala Ala Leu Ser Ala Tyr Asp Met Val Leu Val Glu Asp Asp Glu Val 
225                 230                 235                 240 


Asn Arg Met His Glu Ser Leu His Leu Phe Asn Ser Ile Cys Asn His 
                245                 250                 255     


Lys Phe Phe Ala Ala Thr Ser Ile Val Leu Phe Leu Asn Lys Lys Asp 
            260                 265                 270         


Leu Phe Glu Glu Lys Ile Lys Lys Val His Leu Ser Ile Cys Phe Pro 
        275                 280                 285             


Glu Tyr Asp Gly Asn Asn Ser Tyr Asp Asp Ala Gly Asn Tyr Ile Lys 
    290                 295                 300                 


Ser Gln Phe Leu Asp Leu Asn Met Arg Lys Asp Val Lys Glu Ile Tyr 
305                 310                 315                 320 


Ser His Met Thr Cys Ala Thr Asp Thr Gln Asn Val Lys Phe Val Phe 
                325                 330                 335     


Asp Ala Val Thr Asp Ile Ile Ile Lys Glu Asn Leu Lys Asp Cys Gly 
            340                 345                 350         


Leu Phe 
        


<210>  29
<211>  858
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Gly Glu Ile Asn Gln Val Ala Val Glu Lys Tyr Leu Glu Glu Asn 
1               5                   10                  15      


Pro Gln Phe Ala Lys Glu Tyr Phe Asp Arg Lys Leu Arg Val Glu Val 
            20                  25                  30          


Leu Gly Glu Ile Phe Lys Asn Ser Gln Val Pro Val Gln Ser Ser Met 
        35                  40                  45              


Ser Phe Ser Glu Leu Thr Gln Val Glu Glu Ser Ala Leu Cys Leu Glu 
    50                  55                  60                  


Leu Leu Trp Thr Val Gln Glu Glu Gly Gly Thr Pro Glu Gln Gly Val 
65                  70                  75                  80  


His Arg Ala Leu Gln Arg Leu Ala His Leu Leu Gln Ala Asp Arg Cys 
                85                  90                  95      


Ser Met Phe Leu Cys Arg Ser Arg Asn Gly Ile Pro Glu Val Ala Ser 
            100                 105                 110         


Arg Leu Leu Asp Val Thr Pro Thr Ser Lys Phe Glu Asp Asn Leu Val 
        115                 120                 125             


Gly Pro Asp Lys Glu Val Val Phe Pro Leu Asp Ile Gly Ile Val Gly 
    130                 135                 140                 


Trp Ala Ala His Thr Lys Lys Thr His Asn Val Pro Asp Val Lys Lys 
145                 150                 155                 160 


Asn Ser His Phe Ser Asp Phe Met Asp Lys Gln Thr Gly Tyr Val Thr 
                165                 170                 175     


Lys Asn Leu Leu Ala Thr Pro Ile Val Val Gly Lys Glu Val Leu Ala 
            180                 185                 190         


Val Ile Met Ala Val Asn Lys Val Asn Ala Ser Glu Phe Ser Lys Gln 
        195                 200                 205             


Asp Glu Glu Val Phe Ser Lys Tyr Leu Asn Phe Val Ser Ile Ile Leu 
    210                 215                 220                 


Arg Leu His His Thr Ser Tyr Met Tyr Asn Ile Glu Ser Arg Arg Ser 
225                 230                 235                 240 


Gln Ile Leu Met Trp Ser Ala Asn Lys Val Phe Glu Glu Leu Thr Asp 
                245                 250                 255     


Val Glu Arg Gln Phe His Lys Ala Leu Tyr Thr Val Arg Ser Tyr Leu 
            260                 265                 270         


Asn Cys Glu Arg Tyr Ser Ile Gly Leu Leu Asp Met Thr Lys Glu Lys 
        275                 280                 285             


Glu Phe Tyr Asp Glu Trp Pro Ile Lys Leu Gly Glu Val Glu Pro Tyr 
    290                 295                 300                 


Lys Gly Pro Lys Thr Pro Asp Gly Arg Glu Val Asn Phe Tyr Lys Ile 
305                 310                 315                 320 


Ile Asp Tyr Ile Leu His Gly Lys Glu Glu Ile Lys Val Ile Pro Thr 
                325                 330                 335     


Pro Pro Ala Asp His Trp Thr Leu Ile Ser Gly Leu Pro Thr Tyr Val 
            340                 345                 350         


Ala Glu Asn Gly Phe Ile Cys Asn Met Met Asn Ala Pro Ala Asp Glu 
        355                 360                 365             


Tyr Phe Thr Phe Gln Lys Gly Pro Val Asp Glu Thr Gly Trp Val Ile 
    370                 375                 380                 


Lys Asn Val Leu Ser Leu Pro Ile Val Asn Lys Lys Glu Asp Ile Val 
385                 390                 395                 400 


Gly Val Ala Thr Phe Tyr Asn Arg Lys Asp Gly Lys Pro Phe Asp Glu 
                405                 410                 415     


His Asp Glu Tyr Ile Thr Glu Thr Leu Thr Gln Phe Leu Gly Trp Ser 
            420                 425                 430         


Leu Leu Asn Thr Asp Thr Tyr Asp Lys Met Asn Lys Leu Glu Asn Arg 
        435                 440                 445             


Lys Asp Ile Ala Gln Glu Met Leu Met Asn Gln Thr Lys Ala Thr Pro 
    450                 455                 460                 


Glu Glu Ile Lys Ser Ile Leu Lys Phe Gln Glu Lys Leu Asn Val Asp 
465                 470                 475                 480 


Val Ile Asp Asp Cys Glu Glu Lys Gln Leu Val Ala Ile Leu Lys Glu 
                485                 490                 495     


Asp Leu Pro Asp Pro Arg Ser Ala Glu Leu Tyr Glu Phe Arg Phe Ser 
            500                 505                 510         


Asp Phe Pro Leu Thr Glu His Gly Leu Ile Lys Cys Gly Ile Arg Leu 
        515                 520                 525             


Phe Phe Glu Ile Asn Val Val Glu Lys Phe Lys Val Pro Val Glu Val 
    530                 535                 540                 


Leu Thr Arg Trp Met Tyr Thr Val Arg Lys Gly Tyr Arg Ala Val Thr 
545                 550                 555                 560 


Tyr His Asn Trp Arg His Gly Phe Asn Val Gly Gln Thr Met Phe Thr 
                565                 570                 575     


Leu Leu Met Thr Gly Arg Leu Lys Lys Tyr Tyr Thr Asp Leu Glu Ala 
            580                 585                 590         


Phe Ala Met Leu Ala Ala Ala Phe Cys His Asp Ile Asp His Arg Gly 
        595                 600                 605             


Thr Asn Asn Leu Tyr Gln Met Lys Ser Thr Ser Pro Leu Ala Arg Leu 
    610                 615                 620                 


His Gly Ser Ser Ile Leu Glu Arg His His Leu Glu Tyr Ser Lys Thr 
625                 630                 635                 640 


Leu Leu Gln Asp Glu Ser Leu Asn Ile Phe Gln Asn Leu Asn Lys Arg 
                645                 650                 655     


Gln Phe Glu Thr Val Ile His Leu Phe Glu Val Ala Ile Ile Ala Thr 
            660                 665                 670         


Asp Leu Ala Leu Tyr Phe Lys Lys Arg Thr Met Phe Gln Lys Ile Val 
        675                 680                 685             


Asp Ala Cys Glu Gln Met Gln Thr Glu Glu Glu Ala Ile Lys Tyr Val 
    690                 695                 700                 


Thr Val Asp Pro Thr Lys Lys Glu Ile Ile Met Ala Met Met Met Thr 
705                 710                 715                 720 


Ala Cys Asp Leu Ser Ala Ile Thr Lys Pro Trp Glu Val Gln Ser Gln 
                725                 730                 735     


Val Ala Leu Met Val Ala Asn Glu Phe Trp Glu Gln Gly Asp Leu Glu 
            740                 745                 750         


Arg Thr Val Leu Gln Gln Gln Pro Ile Pro Met Met Asp Arg Asn Lys 
        755                 760                 765             


Arg Asp Glu Leu Pro Lys Leu Gln Val Gly Phe Ile Asp Phe Val Cys 
    770                 775                 780                 


Thr Phe Val Tyr Lys Glu Phe Ser Arg Phe His Lys Glu Ile Thr Pro 
785                 790                 795                 800 


Met Leu Ser Gly Leu Gln Asn Asn Arg Val Glu Trp Lys Ser Leu Ala 
                805                 810                 815     


Asp Glu Tyr Asp Ala Lys Met Lys Val Ile Glu Glu Glu Ala Lys Lys 
            820                 825                 830         


Gln Glu Gly Gly Ala Glu Lys Ala Ala Glu Asp Ser Gly Gly Gly Asp 
        835                 840                 845             


Asp Lys Lys Ser Lys Thr Cys Leu Met Leu 
    850                 855             


<210>  30
<211>  83
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Asp Asn Thr Thr Leu Pro Ala Pro Ala Ser Asn Gln Gly Pro 
1               5                   10                  15      


Thr Thr Pro Arg Lys Gly Pro Pro Lys Phe Lys Gln Arg Gln Thr Arg 
            20                  25                  30          


Gln Phe Lys Ser Lys Pro Pro Lys Lys Gly Val Lys Gly Phe Gly Asp 
        35                  40                  45              


Asp Ile Pro Gly Met Glu Gly Leu Gly Thr Asp Ile Thr Val Ile Cys 
    50                  55                  60                  


Pro Trp Glu Ala Phe Ser His Leu Glu Leu His Glu Leu Ala Gln Phe 
65                  70                  75                  80  


Gly Ile Ile 
            


<210>  31
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Met Ala Tyr Met Asn Pro Gly Pro His Tyr Ser Val Asn Ala Leu 
1               5                   10                  15      


Ala Leu Ser Gly Pro Ser Val Asp Leu Met His Gln Ala Val Pro Tyr 
            20                  25                  30          


Pro Ser Ala Pro Arg Lys Gln Arg Arg Glu Arg Thr Thr Phe Thr Arg 
        35                  40                  45              


Ser Gln Leu Glu Glu Leu Glu Ala Leu Phe Ala Lys Thr Gln Tyr Pro 
    50                  55                  60                  


Asp Val Tyr Ala Arg Glu Glu Val Ala Leu Lys Ile Asn Leu Pro Glu 
65                  70                  75                  80  


Ser Arg Val Gln Val Trp Phe Lys Asn Arg Arg Ala Lys Cys Arg Gln 
                85                  90                  95      


Gln Arg Gln Gln Gln Lys Gln Gln Gln Gln Pro Pro Gly Gly Gln Ala 
            100                 105                 110         


Lys Ala Arg Pro Ala Lys Arg Lys Ala Gly Thr Ser Pro Arg Pro Ser 
        115                 120                 125             


Thr Asp Val Cys Pro Asp Pro Leu Gly Ile Ser Asp Ser Tyr Ser Pro 
    130                 135                 140                 


Pro Leu Pro Gly Pro Ser Gly Ser Pro Thr Thr Ala Val Ala Thr Val 
145                 150                 155                 160 


Ser Ile Trp Ser Pro Ala Ser Glu Ser Pro Leu Pro Glu Ala Gln Arg 
                165                 170                 175     


Ala Gly Leu Val Ala Ser Gly Pro Ser Leu Thr Ser Ala Pro Tyr Ala 
            180                 185                 190         


Met Thr Tyr Ala Pro Ala Ser Ala Phe Cys Ser Ser Pro Ser Ala Tyr 
        195                 200                 205             


Gly Ser Pro Ser Ser Tyr Phe Ser Gly Leu Asp Pro Tyr Leu Ser Pro 
    210                 215                 220                 


Met Val Pro Gln Leu Gly Gly Pro Ala Leu Ser Pro Leu Ser Gly Pro 
225                 230                 235                 240 


Ser Val Gly Pro Ser Leu Ala Gln Ser Pro Thr Ser Leu Ser Gly Gln 
                245                 250                 255     


Ser Tyr Gly Ala Tyr Ser Pro Val Asp Ser Leu Glu Phe Lys Asp Pro 
            260                 265                 270         


Thr Gly Thr Trp Lys Phe Thr Tyr Asn Pro Met Asp Pro Leu Asp Tyr 
        275                 280                 285             


Lys Asp Gln Ser Ala Trp Lys Phe Gln Ile Leu 
    290                 295                 


<210>  32
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Phe Lys Ser Leu Thr Lys Val Asn Lys Val Lys Pro Ile Gly Glu 
1               5                   10                  15      


Asn Asn Glu Asn Glu Gln Ser Ser Arg Arg Asn Glu Glu Gly Ser His 
            20                  25                  30          


Pro Ser Asn Gln Ser Gln Gln Thr Thr Ala Gln Glu Glu Asn Lys Gly 
        35                  40                  45              


Glu Glu Lys Ser Leu Lys Thr Lys Ser Thr Pro Val Thr Ser Glu Glu 
    50                  55                  60                  


Pro His Thr Asn Ile Gln Asp Lys Leu Ser Lys Lys Asn Ser Ser Gly 
65                  70                  75                  80  


Asp Leu Thr Thr Asn Pro Asp Pro Gln Asn Ala Ala Glu Pro Thr Gly 
                85                  90                  95      


Thr Val Pro Glu Gln Lys Glu Met Asp Pro Gly Lys Glu Gly Pro Asn 
            100                 105                 110         


Ser Pro Gln Asn Lys Pro Pro Ala Ala Pro Val Ile Asn Glu Tyr Ala 
        115                 120                 125             


Asp Ala Gln Leu His Asn Leu Val Lys Arg Met Arg Gln Arg Thr Ala 
    130                 135                 140                 


Leu Tyr Lys Lys Lys Leu Val Glu Gly Asp Leu Ser Ser Pro Glu Ala 
145                 150                 155                 160 


Ser Pro Gln Thr Ala Lys Pro Thr Ala Val Pro Pro Val Lys Glu Ser 
                165                 170                 175     


Asp Asp Lys Pro Thr Glu His Tyr Tyr Arg Leu Leu Trp Phe Lys Val 
            180                 185                 190         


Lys Lys Met Pro Leu Thr Glu Tyr Leu Lys Arg Ile Lys Leu Pro Asn 
        195                 200                 205             


Ser Ile Asp Ser Tyr Thr Asp Arg Leu Tyr Leu Leu Trp Leu Leu Leu 
    210                 215                 220                 


Val Thr Leu Ala Tyr Asn Trp Asn Cys Trp Phe Ile Pro Leu Arg Leu 
225                 230                 235                 240 


Val Phe Pro Tyr Gln Thr Ala Asp Asn Ile His Tyr Trp Leu Ile Ala 
                245                 250                 255     


Asp Ile Ile Cys Asp Ile Ile Tyr Leu Tyr Asp Met Leu Phe Ile Gln 
            260                 265                 270         


Pro Arg Leu Gln Phe Val Arg Gly Gly Asp Ile Ile Val Asp Ser Asn 
        275                 280                 285             


Glu Leu Arg Lys His Tyr Arg Thr Ser Thr Lys Phe Gln Leu Asp Val 
    290                 295                 300                 


Ala Ser Ile Ile Pro Phe Asp Ile Cys Tyr Leu Phe Phe Gly Phe Asn 
305                 310                 315                 320 


Pro Met Phe Arg Ala Asn Arg Met Leu Lys Tyr Thr Ser Phe Phe Glu 
                325                 330                 335     


Phe Asn His His Leu Glu Ser Ile Met Asp Lys Ala Tyr Ile Tyr Arg 
            340                 345                 350         


Val Ile Arg Thr Thr Gly Tyr Leu Leu Phe Ile Leu His Ile Asn Ala 
        355                 360                 365             


Cys Val Tyr Tyr Trp Ala Ser Asn Tyr Glu Gly Ile Gly Thr Thr Arg 
    370                 375                 380                 


Trp Val Tyr Asp Gly Glu Gly Asn Glu Tyr Leu Arg Cys Tyr Tyr Trp 
385                 390                 395                 400 


Ala Val Arg Thr Leu Ile Thr Ile Gly Gly Leu Pro Glu Pro Gln Thr 
                405                 410                 415     


Leu Phe Glu Ile Val Phe Gln Leu Leu Asn Phe Phe Ser Gly Val Phe 
            420                 425                 430         


Val Phe Ser Ser Leu Ile Gly Gln Met Arg Asp Val Ile Gly Ala Ala 
        435                 440                 445             


Thr Ala Asn Gln Asn Tyr Phe Arg Ala Cys Met Asp Asp Thr Ile Ala 
    450                 455                 460                 


Tyr Met Asn Asn Tyr Ser Ile Pro Lys Leu Val Gln Lys Arg Val Arg 
465                 470                 475                 480 


Thr Trp Tyr Glu Tyr Thr Trp Asp Ser Gln Arg Met Leu Asp Glu Ser 
                485                 490                 495     


Asp Leu Leu Lys Thr Leu Pro Thr Thr Val Gln Leu Ala Leu Ala Ile 
            500                 505                 510         


Asp Val Asn Phe Ser Ile Ile Ser Lys Val Asp Leu Phe Lys Gly Cys 
        515                 520                 525             


Asp Thr Gln Met Ile Tyr Asp Met Leu Leu Arg Leu Lys Ser Val Leu 
    530                 535                 540                 


Tyr Leu Pro Gly Asp Phe Val Cys Lys Lys Gly Glu Ile Gly Lys Glu 
545                 550                 555                 560 


Met Tyr Ile Ile Lys His Gly Glu Val Gln Val Leu Gly Gly Pro Asp 
                565                 570                 575     


Gly Thr Lys Val Leu Val Thr Leu Lys Ala Gly Ser Val Phe Gly Glu 
            580                 585                 590         


Ile Ser Leu Leu Ala Ala Gly Gly Gly Asn Arg Arg Thr Ala Asn Val 
        595                 600                 605             


Val Ala His Gly Phe Ala Asn Leu Leu Thr Leu Asp Lys Lys Thr Leu 
    610                 615                 620                 


Gln Glu Ile Leu Val His Tyr Pro Asp Ser Glu Arg Ile Leu Met Lys 
625                 630                 635                 640 


Lys Ala Arg Val Leu Leu Lys Gln Lys Ala Lys Thr Ala Glu Ala Thr 
                645                 650                 655     


Pro Pro Arg Lys Asp Leu Ala Leu Leu Phe Pro Pro Lys Glu Glu Thr 
            660                 665                 670         


Pro Lys Leu Phe Lys Thr Leu Leu Gly Gly Thr Gly Lys Ala Ser Leu 
        675                 680                 685             


Ala Arg Leu Leu Lys Leu Lys Arg Glu Gln Ala Ala Gln Lys Lys Glu 
    690                 695                 700                 


Asn Ser Glu Gly Gly Glu Glu Glu Gly Lys Glu Asn Glu Asp Lys Gln 
705                 710                 715                 720 


Lys Glu Asn Glu Asp Lys Gln Lys Glu Asn Glu Asp Lys Gly Lys Glu 
                725                 730                 735     


Asn Glu Asp Lys Asp Lys Gly Arg Glu Pro Glu Glu Lys Pro Leu Asp 
            740                 745                 750         


Arg Pro Glu Cys Thr Ala Ser Pro Ile Ala Val Glu Glu Glu Pro His 
        755                 760                 765             


Ser Val Arg Arg Thr Val Leu Pro Arg Gly Thr Ser Arg Gln Ser Leu 
    770                 775                 780                 


Ile Ile Ser Met Ala Pro Ser Ala Glu Gly Gly Glu Glu Val Leu Thr 
785                 790                 795                 800 


Ile Glu Val Lys Glu Lys Ala Lys Gln 
                805                 


<210>  33
<211>  610
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Pro Leu Thr Glu Tyr Leu Lys Arg Ile Lys Leu Pro Asn Ser Ile 
1               5                   10                  15      


Asp Ser Tyr Thr Asp Arg Leu Tyr Leu Leu Trp Leu Leu Leu Val Thr 
            20                  25                  30          


Leu Ala Tyr Asn Trp Asn Cys Cys Phe Ile Pro Leu Arg Leu Val Phe 
        35                  40                  45              


Pro Tyr Gln Thr Ala Asp Asn Ile His Tyr Trp Leu Ile Ala Asp Ile 
    50                  55                  60                  


Ile Cys Asp Ile Ile Tyr Leu Tyr Asp Met Leu Phe Ile Gln Pro Arg 
65                  70                  75                  80  


Leu Gln Phe Val Arg Gly Gly Asp Ile Ile Val Asp Ser Asn Glu Leu 
                85                  90                  95      


Arg Lys His Tyr Arg Thr Ser Thr Lys Phe Gln Leu Asp Val Ala Ser 
            100                 105                 110         


Ile Ile Pro Phe Asp Ile Cys Tyr Leu Phe Phe Gly Phe Asn Pro Met 
        115                 120                 125             


Phe Arg Ala Asn Arg Met Leu Lys Tyr Thr Ser Phe Phe Glu Phe Asn 
    130                 135                 140                 


His His Leu Glu Ser Ile Met Asp Lys Ala Tyr Ile Tyr Arg Val Ile 
145                 150                 155                 160 


Arg Thr Thr Gly Tyr Leu Leu Phe Ile Leu His Ile Asn Ala Cys Val 
                165                 170                 175     


Tyr Tyr Trp Ala Ser Asn Tyr Glu Gly Ile Gly Thr Thr Arg Trp Val 
            180                 185                 190         


Tyr Asp Gly Glu Gly Asn Glu Tyr Leu Arg Cys Tyr Tyr Trp Ala Val 
        195                 200                 205             


Arg Thr Leu Ile Thr Ile Gly Gly Leu Pro Glu Pro Gln Thr Leu Phe 
    210                 215                 220                 


Glu Ile Val Phe Gln Leu Leu Asn Phe Phe Ser Gly Val Phe Val Phe 
225                 230                 235                 240 


Ser Ser Leu Ile Gly Gln Met Arg Asp Val Ile Gly Ala Ala Thr Ala 
                245                 250                 255     


Asn Gln Asn Tyr Phe Arg Ala Cys Met Asp Asp Thr Ile Ala Tyr Met 
            260                 265                 270         


Asn Asn Tyr Ser Ile Pro Lys Leu Val Gln Lys Arg Val Arg Thr Trp 
        275                 280                 285             


Tyr Glu Tyr Thr Trp Asp Ser Gln Arg Met Leu Asp Glu Ser Asp Leu 
    290                 295                 300                 


Leu Lys Thr Leu Pro Thr Thr Val Gln Leu Ala Leu Ala Ile Asp Val 
305                 310                 315                 320 


Asn Phe Ser Ile Ile Ser Lys Val Asp Leu Phe Lys Gly Cys Asp Thr 
                325                 330                 335     


Gln Met Ile Tyr Asp Met Leu Leu Arg Leu Lys Ser Val Leu Tyr Leu 
            340                 345                 350         


Pro Gly Asp Phe Val Cys Lys Lys Gly Glu Ile Gly Lys Glu Met Tyr 
        355                 360                 365             


Ile Ile Lys His Gly Glu Val Gln Val Leu Gly Gly Pro Asp Gly Thr 
    370                 375                 380                 


Lys Val Leu Val Thr Leu Lys Ala Gly Ser Val Leu Leu Ala Ala Gly 
385                 390                 395                 400 


Gly Gly Asn Arg Arg Thr Ala Asn Val Val Ala His Gly Phe Ala Asn 
                405                 410                 415     


Leu Leu Thr Leu Asp Lys Lys Thr Leu Gln Glu Ile Leu Val His Tyr 
            420                 425                 430         


Pro Asp Ser Glu Arg Ile Leu Met Lys Lys Ala Arg Val Leu Leu Lys 
        435                 440                 445             


Gln Lys Ala Lys Thr Ala Glu Ala Thr Pro Pro Arg Lys Asp Leu Ala 
    450                 455                 460                 


Leu Leu Phe Pro Pro Lys Glu Glu Thr Pro Lys Leu Phe Lys Thr Leu 
465                 470                 475                 480 


Leu Gly Gly Thr Gly Lys Ala Ser Leu Ala Arg Leu Leu Lys Leu Lys 
                485                 490                 495     


Arg Glu Gln Ala Ala Gln Lys Lys Glu Asn Ser Glu Gly Gly Glu Glu 
            500                 505                 510         


Glu Gly Lys Glu Asn Glu Asp Lys Gln Lys Glu Asn Glu Asp Lys Gln 
        515                 520                 525             


Lys Glu Asn Glu Asp Lys Gly Lys Glu Asn Glu Asp Lys Asp Lys Gly 
    530                 535                 540                 


Arg Glu Pro Glu Glu Lys Pro Leu Asp Arg Pro Glu Cys Thr Ala Ser 
545                 550                 555                 560 


Pro Ile Ala Val Glu Glu Glu Pro His Ser Val Arg Arg Thr Val Leu 
                565                 570                 575     


Pro Arg Gly Thr Ser Arg Gln Ser Leu Ile Ile Ser Met Ala Pro Ser 
            580                 585                 590         


Ala Glu Gly Gly Glu Glu Val Leu Thr Ile Glu Val Lys Glu Lys Ala 
        595                 600                 605             


Lys Gln 
    610 


<210>  34
<211>  7100
<212>  DNA
<213>  Homo sapiens

<400>  34
gacatactga gaataaatcc aaagacatta gtttctttgc acgaaatgag gttacatatc       60

cagtgacatt tatttgagct atttaaacaa cttaaacatc tttttctttt cttaataagg      120

gacgtttcaa gttgtggtct cagccaaaat gagtgatacc ccttctactg gtttttccat      180

cattcatcct acgtcttctg aaggtcaagt tccaccccct cgccatttga gcctcactca      240

tcctgttgtg gccaagcgaa tcagtttcta caagagcgga gacccccaat tcggcggggt      300

cagggtggtg gtcaaccctc gctcctttaa gtcctttgat gctctgctgg ataacttgtc      360

caggaaggtg cccctccctt ttggagtgag gaacatcagc acccctcggg gcaggcacag      420

catcacgcgc ctggaggagc tggaggacgg cgagtcctac ctatgttccc acggcaggaa      480

ggtgcagcct gtagacctgg acaaagcccg tcggcgcccg cggccctggc tcagcagccg      540

ggccattagc gcgcactcac cgccccaccc cgtagccgtc gctgctcccg gcatgccccg      600

ccccccacgg agcctagtgg tcttcaggaa tggcgacccg aagacgaggc gtgcggttct      660

tctgagcagg agggtcaccc agagcttcga ggcatttcta cagcacctga cagaggtcat      720

gcagcgccct gtggtcaagc tgtacgctac ggacggaagg agggttccca gcctccaggc      780

agtgatcctg agctctggag ctgtggtggc ggcaggaagg gagccattta aaccaggaaa      840

ttatgacatc caaaaatact tgcttcctgc tagattacca gggatctctc agcgtgtgta      900

ccccaaggga aatgcaaagt cagaaagcag aaagataagc acacatatgt cttcaagctc      960

aaggtcccag atttattctg tttcttctga gaaaacacat aataatgatt gctacttaga     1020

ctattctttt gttcctgaaa agtacttggc cttagaaaag aatgattctc agaatttacc     1080

aatatatcct tctgaagatg atattgagaa atcaattatt tttaatcaag acggcactat     1140

gacagttgag atgaaagttc gattcagaat aaaagaggaa gaaaccataa aatggacaac     1200

tactgtcagt aaaactggtc cttctaataa tgatgaaaag agtgagatga gttttccagg     1260

aagaacagaa agtcgatcat ctggtttaaa gcttgcagca tgttcattct ctgcagatgt     1320

gtcacctatg gagcgaagca gtaatcaaga gggcagtttg gcagaggaga taaacattca     1380

aatgacagat caagtggctg aaacttgcag ttctgctagt tgggagaatg ctactgtgga     1440

cacagatatc atccagggaa ctcaagacca agcaaagcat cgtttttata ggccccctac     1500

acctggacta agaagagtga gacaaaagaa atctgtgatt ggcagtgtga ccttagtatc     1560

tgaaactgag gttcaagaga aaatgattgg acagttttca tatagtgaag aaagggaaag     1620

tggggaaaac aagtctgagt atcacatgtt tacacattct tgcagtaaaa tgtcatcagt     1680

atctaacaaa ccagtacttg ttcagatcaa taacaatgat caaatggagg agtcatcatt     1740

agaaagaaaa aaggaaaaca gtctgcttaa gtcaagtgca ataagtgctg gtgttataga     1800

aattacaagt cagaagatgt tagagatgtc acataataat ggtttgccat caactatatc     1860

aaataactca attgtggagg aagatgtagt tgattgtgtg gtattggaca acaaaactgg     1920

tatcaagaac ttcaaaactt atggtaacac caatgatagg ttcagtccta tttcagcaga     1980

tgcaacccat ttttcaagta ataactctgg aactgacaaa aatatttctg aggctccagc     2040

ttcagaagca tcctctactg tcactgcaag aattgacaga ctaattaatg aatttgctca     2100

gtgtggttta acaaaacttc caaaaaatga aaagaagatt ttgtcatctg ttgccagcaa     2160

aaagaagaaa aaatctcgac agcaagcaat aaattccagg tatcaagatg gacagcttgc     2220

aaccaaagga attcttaata agaatgagag aataaacaca aaaggtagaa ttacaaagga     2280

aatgatagtg caagattcag atagtcccct taaaggaggg atactttgtg aggaagacct     2340

ccagaaaagt gatactgtaa ttgaatcaaa tactttttgt tccaaaagta atctcaattc     2400

cacgatttcc aagaatttcc atagaaataa attaaatact actcaaaatt ccaaggttca     2460

aggactttta accaaaagaa aatctagatc actaaataaa ataagcttag gagcacctaa     2520

aaaaagagaa atcggtcaaa gagataaagt gtttcctcac aatgaatcta aatattgcaa     2580

aagtactttt gaaaacaaaa gtttatttca tgtatttaac atccttgagc aaaaacccaa     2640

agatttttat gcaccgcaat ctcaagcaga agtggcatct gggtatttga gaggaatggc     2700

aaagaagagt ttagtttcaa aagttactga ttcacacata actttaaaaa gccagaaaaa     2760

acgtaaaggg gataaagtga aagcaagtgc tattttaagt aaacaacatg ctacaaccag     2820

ggcaaattct ttagcttctt tgaaaaaacc tgattttcct gaggctattg ctcatcattc     2880

aattcaaaat tatatacaga gttggttgca gaacataaat ccatatccaa ctttaaagcc     2940

tataaaatca gctccagtat gtagaaatga aacgagtgtg gtaaattgta gcaataatag     3000

tttttcaggg aatgatcccc atacaaattc tggaaaaata agtaattttg ttatggaaag     3060

taataagcac ataactaaaa ttgccggttt gacaggagat aatctatgta aagagggaga     3120

taagtctttt attgccaatg acactggtga agaagatctc catgagacac aggttggatc     3180

tctgaatgat gcttatttgg ttcccctgca tgaacactgt actttgtcac agtcagctat     3240

taatgatcat aatactaaaa gtcatatagc tgctgaaaaa tcaggaccag agaaaaaact     3300

tgtttaccag gaaataaacc tagctagaaa aaggcaaagt gtagaggctg ccattcaagt     3360

agatcctata gaagaggaaa ctccaaaaga cctcttacca gtcctgatgc ttcaccaatt     3420

gcaagcttca gttcctggta ttcacaagac tcagaatgga gttgttcaaa tgccaggttc     3480

acttgcaggt gttccctttc attctgcaat atgtaattca tccactaatc tccttctagc     3540

ttggctcttg gtgctaaacc taaagggaag tatgaatagc ttctgtcaag ttgatgctca     3600

caaggctacc aacaaatctt cagaaacact tgcattgttg gagattctaa agcacatagc     3660

tatcacagag gaagctgatg acttgaaagc tgctgttgcc aatttagtgg agtcaactac     3720

aagccacttt ggactcagtg agaaagaaca agacatggtt ccaatagatc tttctgcaaa     3780

ttgttccacg gtcaacattc agagtgttcc taagtgcagt gaaaatgaaa gaacacaagg     3840

aatctcctct ttggatggag gttgctctgc cagtgaggca tgtgcccctg aagtctgtgt     3900

tttggaagtg acttgctctc catgtgagat gtgcactgta aataaggctt attctccaaa     3960

agagacatgt aaccccagtg acactttttt tcctagtgat ggttatggtg tggatcagac     4020

ttctatgaat aaggcttgtt tcctaggaga ggtctgttca cttactgata ctgtgttttc     4080

tgataaggct tgtgctcaaa aggagaacca tacctatgag ggagcttgcc caattgatga     4140

gacctacgtt cctgtcaatg tctgcaatac cattgacttt ttaaactcca aagaaaacac     4200

atatactgat aacttggatt caactgaaga gttagaaaga ggtgatgaca ttcagaaaga     4260

tctaaatatt ttgacagacc ctgaatataa aaatggattt aatacattgg tgtcacatca     4320

aaatgtcagt aatttaagct cctgtggcct ttgcctaagt gaaaaagaag cagaacttga     4380

taagaaacat agttctctag atgattttga aaattgttca ctaaggaagt ttcaggatga     4440

aaatgcatat acttcctttg atatggaaga accacggact tctgaagaac caggctcaat     4500

aaccaacagc atgacatcaa gtgaaagaaa catttcagaa ttggaatctt ttgaagaatt     4560

agaaaaccat gacactgata tctttaatac agtggtaaat ggaggagagc aagccactga     4620

agaattaatc caagaagagg tagaggctag taaaacttta gaattgatag acatctctag     4680

taagaatatt atggaagaaa aaagaatgaa cggtataatt tatgaaataa tcagtaagag     4740

gctggcaaca ccaccatctt tagatttttg ctatgattct aagcaaaata gtgaaaagga     4800

gaccaatgaa ggagaaacta agatggtaaa aatgatggtg aaaactatgg aaactggaag     4860

ttattcagag tcctctcctg atttaaaaaa atgcatcaaa agtccagtga cttctgattg     4920

gtcagactat cggcctgaca gtgacagtga gcagccatat aaaacatcca gtgatgatcc     4980

caatgacagt ggcgaactta cccaagagaa agaatataac ataggatttg ttaaaagggc     5040

aatagaaaaa ctgtacggta aagcagatat tatcaaacca tctttttttc ctgggtctac     5100

ccgcaaatct caggtttgtc cttataattc tgtggaattt cagtgttcca ggaaagcaag     5160

tctttatgat tctgaagggc agtcatttgg ctcttctgaa caggtatcta gtagttcatc     5220

tatgttgcag gaattccagg aggaaagaca agataagtgt gatgttagtg ctgtgaggga     5280

caattattgt aggggtgaca ttgtagaacc tggtacaaaa caaaatgatg atagcagaat     5340

cctcacagac atagaggaag gagtactgat tgacaaaggc aaatggcttc tgaaagaaaa     5400

tcatttgcta aggatgtcat ctgaaaatcc tggcatgtgt ggcaatgcag acaccacatc     5460

agtggacacc ctacttgata ataacagcag tgaggtacca tattcacatt ttggtaattt     5520

ggccccaggc ccaacgatgg atgaactctc ctcttcagaa ctcgaggaac tgactcaacc     5580

ccttgaacta aaatgcaatt actttaacat gcctcatggt agtgactcag aaccttttca     5640

tgaggacttg ctggatgttc gcaatgaaac ctgtgccaag gaaagaatag caaatcatca     5700

tacagaggag aagggtagtc atcagtcaga aagagtatgc acatctgtca ctcattcctt     5760

tatttctgct ggtaacaaag tctaccctgt ctctgatgat gctattaaaa accaaccatt     5820

gcctggcagt aatatgattc atggtacact tcaggaagct gactctttgg ataaactgta     5880

tgctctttgt ggtcaacatt gcccaatact aactgttatt atccaaccca tgaatgagga     5940

agaccgagga tttgcatatc gcaaagaatc tgatattgaa aatttcttgg gtttttattt     6000

atggatgaaa atacacccat atttacttca gacagacaaa aatgtgttca gggaagagaa     6060

caataaagca agtatgagac aaaatcttat tgataatgcc attggtgata tatttgatca     6120

gttttatttc agtaacacat ttgacttgat gggtaaaaga agaaaacaaa aaagaattaa     6180

cttcttgggg ttagaggaag aaggtaattt aaagaaattt caaccagatt tgaaggaaag     6240

gttttgtatg aatttcttgc acacatcatt gttagttgtg ggtaatgtgg attcaaatac     6300

acaagacctc agcggtcaga caaatgaaat ctttaaagca gtcgatgaga ataacaactt     6360

attaaataac agattccagg gctcaagaac aaatctcaac caagtagtaa gagaaaatat     6420

caactgtcat tacttctttg aaatgcttgg tcaagcttgc ctcttagata tttgccaagt     6480

tgagacctcc ttaaatatta gcaacagaaa tattttagaa ctttgtatgt ttgagggtga     6540

aaatcttttc atttgggaag aggaagacat attaaattta actgatcttg aaagcagtag     6600

agaacaagaa gatttataat ttcaatatca gcacactcat tctttgtcaa ttcatttttt     6660

cccatgagat gaagcacatg tgacgaatac ggactagata acctctaaga attttccact     6720

tcttcaaaat gaacttactc tagaaagctt acccttggat aaccagtttg actttcataa     6780

tgtctctgtt ttttgttttt ccaacaatta cagactcagg ttctcttatt ttggaagttt     6840

ctatctggtt ttgttctgaa cttacatttt tttttttttt ggtatctatg attttttttg     6900

ctcagggcat caaaatgtgc taaggacaag aattatatcc tttttaaaaa atgttgttag     6960

cttggtgtaa aatgtatatt gactgtattg gtgaataaat tgaatagaca taacctcaaa     7020

gtacttcact tattcttttt aactactgat ttgataaaaa gtatgattat aagatatcca     7080

cgacaatctc atagtttctt                                                 7100


<210>  35
<211>  2156
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ser Asp Thr Pro Ser Thr Gly Phe Ser Ile Ile His Pro Thr Ser 
1               5                   10                  15      


Ser Glu Gly Gln Val Pro Pro Pro Arg His Leu Ser Leu Thr His Pro 
            20                  25                  30          


Val Val Ala Lys Arg Ile Ser Phe Tyr Lys Ser Gly Asp Pro Gln Phe 
        35                  40                  45              


Gly Gly Val Arg Val Val Val Asn Pro Arg Ser Phe Lys Ser Phe Asp 
    50                  55                  60                  


Ala Leu Leu Asp Asn Leu Ser Arg Lys Val Pro Leu Pro Phe Gly Val 
65                  70                  75                  80  


Arg Asn Ile Ser Thr Pro Arg Gly Arg His Ser Ile Thr Arg Leu Glu 
                85                  90                  95      


Glu Leu Glu Asp Gly Glu Ser Tyr Leu Cys Ser His Gly Arg Lys Val 
            100                 105                 110         


Gln Pro Val Asp Leu Asp Lys Ala Arg Arg Arg Pro Arg Pro Trp Leu 
        115                 120                 125             


Ser Ser Arg Ala Ile Ser Ala His Ser Pro Pro His Pro Val Ala Val 
    130                 135                 140                 


Ala Ala Pro Gly Met Pro Arg Pro Pro Arg Ser Leu Val Val Phe Arg 
145                 150                 155                 160 


Asn Gly Asp Pro Lys Thr Arg Arg Ala Val Leu Leu Ser Arg Arg Val 
                165                 170                 175     


Thr Gln Ser Phe Glu Ala Phe Leu Gln His Leu Thr Glu Val Met Gln 
            180                 185                 190         


Arg Pro Val Val Lys Leu Tyr Ala Thr Asp Gly Arg Arg Val Pro Ser 
        195                 200                 205             


Leu Gln Ala Val Ile Leu Ser Ser Gly Ala Val Val Ala Ala Gly Arg 
    210                 215                 220                 


Glu Pro Phe Lys Pro Gly Asn Tyr Asp Ile Gln Lys Tyr Leu Leu Pro 
225                 230                 235                 240 


Ala Arg Leu Pro Gly Ile Ser Gln Arg Val Tyr Pro Lys Gly Asn Ala 
                245                 250                 255     


Lys Ser Glu Ser Arg Lys Ile Ser Thr His Met Ser Ser Ser Ser Arg 
            260                 265                 270         


Ser Gln Ile Tyr Ser Val Ser Ser Glu Lys Thr His Asn Asn Asp Cys 
        275                 280                 285             


Tyr Leu Asp Tyr Ser Phe Val Pro Glu Lys Tyr Leu Ala Leu Glu Lys 
    290                 295                 300                 


Asn Asp Ser Gln Asn Leu Pro Ile Tyr Pro Ser Glu Asp Asp Ile Glu 
305                 310                 315                 320 


Lys Ser Ile Ile Phe Asn Gln Asp Gly Thr Met Thr Val Glu Met Lys 
                325                 330                 335     


Val Arg Phe Arg Ile Lys Glu Glu Glu Thr Ile Lys Trp Thr Thr Thr 
            340                 345                 350         


Val Ser Lys Thr Gly Pro Ser Asn Asn Asp Glu Lys Ser Glu Met Ser 
        355                 360                 365             


Phe Pro Gly Arg Thr Glu Ser Arg Ser Ser Gly Leu Lys Leu Ala Ala 
    370                 375                 380                 


Cys Ser Phe Ser Ala Asp Val Ser Pro Met Glu Arg Ser Ser Asn Gln 
385                 390                 395                 400 


Glu Gly Ser Leu Ala Glu Glu Ile Asn Ile Gln Met Thr Asp Gln Val 
                405                 410                 415     


Ala Glu Thr Cys Ser Ser Ala Ser Trp Glu Asn Ala Thr Val Asp Thr 
            420                 425                 430         


Asp Ile Ile Gln Gly Thr Gln Asp Gln Ala Lys His Arg Phe Tyr Arg 
        435                 440                 445             


Pro Pro Thr Pro Gly Leu Arg Arg Val Arg Gln Lys Lys Ser Val Ile 
    450                 455                 460                 


Gly Ser Val Thr Leu Val Ser Glu Thr Glu Val Gln Glu Lys Met Ile 
465                 470                 475                 480 


Gly Gln Phe Ser Tyr Ser Glu Glu Arg Glu Ser Gly Glu Asn Lys Ser 
                485                 490                 495     


Glu Tyr His Met Phe Thr His Ser Cys Ser Lys Met Ser Ser Val Ser 
            500                 505                 510         


Asn Lys Pro Val Leu Val Gln Ile Asn Asn Asn Asp Gln Met Glu Glu 
        515                 520                 525             


Ser Ser Leu Glu Arg Lys Lys Glu Asn Ser Leu Leu Lys Ser Ser Ala 
    530                 535                 540                 


Ile Ser Ala Gly Val Ile Glu Ile Thr Ser Gln Lys Met Leu Glu Met 
545                 550                 555                 560 


Ser His Asn Asn Gly Leu Pro Ser Thr Ile Ser Asn Asn Ser Ile Val 
                565                 570                 575     


Glu Glu Asp Val Val Asp Cys Val Val Leu Asp Asn Lys Thr Gly Ile 
            580                 585                 590         


Lys Asn Phe Lys Thr Tyr Gly Asn Thr Asn Asp Arg Phe Ser Pro Ile 
        595                 600                 605             


Ser Ala Asp Ala Thr His Phe Ser Ser Asn Asn Ser Gly Thr Asp Lys 
    610                 615                 620                 


Asn Ile Ser Glu Ala Pro Ala Ser Glu Ala Ser Ser Thr Val Thr Ala 
625                 630                 635                 640 


Arg Ile Asp Arg Leu Ile Asn Glu Phe Ala Gln Cys Gly Leu Thr Lys 
                645                 650                 655     


Leu Pro Lys Asn Glu Lys Lys Ile Leu Ser Ser Val Ala Ser Lys Lys 
            660                 665                 670         


Lys Lys Lys Ser Arg Gln Gln Ala Ile Asn Ser Arg Tyr Gln Asp Gly 
        675                 680                 685             


Gln Leu Ala Thr Lys Gly Ile Leu Asn Lys Asn Glu Arg Ile Asn Thr 
    690                 695                 700                 


Lys Gly Arg Ile Thr Lys Glu Met Ile Val Gln Asp Ser Asp Ser Pro 
705                 710                 715                 720 


Leu Lys Gly Gly Ile Leu Cys Glu Glu Asp Leu Gln Lys Ser Asp Thr 
                725                 730                 735     


Val Ile Glu Ser Asn Thr Phe Cys Ser Lys Ser Asn Leu Asn Ser Thr 
            740                 745                 750         


Ile Ser Lys Asn Phe His Arg Asn Lys Leu Asn Thr Thr Gln Asn Ser 
        755                 760                 765             


Lys Val Gln Gly Leu Leu Thr Lys Arg Lys Ser Arg Ser Leu Asn Lys 
    770                 775                 780                 


Ile Ser Leu Gly Ala Pro Lys Lys Arg Glu Ile Gly Gln Arg Asp Lys 
785                 790                 795                 800 


Val Phe Pro His Asn Glu Ser Lys Tyr Cys Lys Ser Thr Phe Glu Asn 
                805                 810                 815     


Lys Ser Leu Phe His Val Phe Asn Ile Leu Glu Gln Lys Pro Lys Asp 
            820                 825                 830         


Phe Tyr Ala Pro Gln Ser Gln Ala Glu Val Ala Ser Gly Tyr Leu Arg 
        835                 840                 845             


Gly Met Ala Lys Lys Ser Leu Val Ser Lys Val Thr Asp Ser His Ile 
    850                 855                 860                 


Thr Leu Lys Ser Gln Lys Lys Arg Lys Gly Asp Lys Val Lys Ala Ser 
865                 870                 875                 880 


Ala Ile Leu Ser Lys Gln His Ala Thr Thr Arg Ala Asn Ser Leu Ala 
                885                 890                 895     


Ser Leu Lys Lys Pro Asp Phe Pro Glu Ala Ile Ala His His Ser Ile 
            900                 905                 910         


Gln Asn Tyr Ile Gln Ser Trp Leu Gln Asn Ile Asn Pro Tyr Pro Thr 
        915                 920                 925             


Leu Lys Pro Ile Lys Ser Ala Pro Val Cys Arg Asn Glu Thr Ser Val 
    930                 935                 940                 


Val Asn Cys Ser Asn Asn Ser Phe Ser Gly Asn Asp Pro His Thr Asn 
945                 950                 955                 960 


Ser Gly Lys Ile Ser Asn Phe Val Met Glu Ser Asn Lys His Ile Thr 
                965                 970                 975     


Lys Ile Ala Gly Leu Thr Gly Asp Asn Leu Cys Lys Glu Gly Asp Lys 
            980                 985                 990         


Ser Phe Ile Ala Asn Asp Thr Gly  Glu Glu Asp Leu His  Glu Thr Gln 
        995                 1000                 1005             


Val Gly  Ser Leu Asn Asp Ala  Tyr Leu Val Pro Leu  His Glu His 
    1010                 1015                 1020             


Cys Thr  Leu Ser Gln Ser Ala  Ile Asn Asp His Asn  Thr Lys Ser 
    1025                 1030                 1035             


His Ile  Ala Ala Glu Lys Ser  Gly Pro Glu Lys Lys  Leu Val Tyr 
    1040                 1045                 1050             


Gln Glu  Ile Asn Leu Ala Arg  Lys Arg Gln Ser Val  Glu Ala Ala 
    1055                 1060                 1065             


Ile Gln  Val Asp Pro Ile Glu  Glu Glu Thr Pro Lys  Asp Leu Leu 
    1070                 1075                 1080             


Pro Val  Leu Met Leu His Gln  Leu Gln Ala Ser Val  Pro Gly Ile 
    1085                 1090                 1095             


His Lys  Thr Gln Asn Gly Val  Val Gln Met Pro Gly  Ser Leu Ala 
    1100                 1105                 1110             


Gly Val  Pro Phe His Ser Ala  Ile Cys Asn Ser Ser  Thr Asn Leu 
    1115                 1120                 1125             


Leu Leu  Ala Trp Leu Leu Val  Leu Asn Leu Lys Gly  Ser Met Asn 
    1130                 1135                 1140             


Ser Phe  Cys Gln Val Asp Ala  His Lys Ala Thr Asn  Lys Ser Ser 
    1145                 1150                 1155             


Glu Thr  Leu Ala Leu Leu Glu  Ile Leu Lys His Ile  Ala Ile Thr 
    1160                 1165                 1170             


Glu Glu  Ala Asp Asp Leu Lys  Ala Ala Val Ala Asn  Leu Val Glu 
    1175                 1180                 1185             


Ser Thr  Thr Ser His Phe Gly  Leu Ser Glu Lys Glu  Gln Asp Met 
    1190                 1195                 1200             


Val Pro  Ile Asp Leu Ser Ala  Asn Cys Ser Thr Val  Asn Ile Gln 
    1205                 1210                 1215             


Ser Val  Pro Lys Cys Ser Glu  Asn Glu Arg Thr Gln  Gly Ile Ser 
    1220                 1225                 1230             


Ser Leu  Asp Gly Gly Cys Ser  Ala Ser Glu Ala Cys  Ala Pro Glu 
    1235                 1240                 1245             


Val Cys  Val Leu Glu Val Thr  Cys Ser Pro Cys Glu  Met Cys Thr 
    1250                 1255                 1260             


Val Asn  Lys Ala Tyr Ser Pro  Lys Glu Thr Cys Asn  Pro Ser Asp 
    1265                 1270                 1275             


Thr Phe  Phe Pro Ser Asp Gly  Tyr Gly Val Asp Gln  Thr Ser Met 
    1280                 1285                 1290             


Asn Lys  Ala Cys Phe Leu Gly  Glu Val Cys Ser Leu  Thr Asp Thr 
    1295                 1300                 1305             


Val Phe  Ser Asp Lys Ala Cys  Ala Gln Lys Glu Asn  His Thr Tyr 
    1310                 1315                 1320             


Glu Gly  Ala Cys Pro Ile Asp  Glu Thr Tyr Val Pro  Val Asn Val 
    1325                 1330                 1335             


Cys Asn  Thr Ile Asp Phe Leu  Asn Ser Lys Glu Asn  Thr Tyr Thr 
    1340                 1345                 1350             


Asp Asn  Leu Asp Ser Thr Glu  Glu Leu Glu Arg Gly  Asp Asp Ile 
    1355                 1360                 1365             


Gln Lys  Asp Leu Asn Ile Leu  Thr Asp Pro Glu Tyr  Lys Asn Gly 
    1370                 1375                 1380             


Phe Asn  Thr Leu Val Ser His  Gln Asn Val Ser Asn  Leu Ser Ser 
    1385                 1390                 1395             


Cys Gly  Leu Cys Leu Ser Glu  Lys Glu Ala Glu Leu  Asp Lys Lys 
    1400                 1405                 1410             


His Ser  Ser Leu Asp Asp Phe  Glu Asn Cys Ser Leu  Arg Lys Phe 
    1415                 1420                 1425             


Gln Asp  Glu Asn Ala Tyr Thr  Ser Phe Asp Met Glu  Glu Pro Arg 
    1430                 1435                 1440             


Thr Ser  Glu Glu Pro Gly Ser  Ile Thr Asn Ser Met  Thr Ser Ser 
    1445                 1450                 1455             


Glu Arg  Asn Ile Ser Glu Leu  Glu Ser Phe Glu Glu  Leu Glu Asn 
    1460                 1465                 1470             


His Asp  Thr Asp Ile Phe Asn  Thr Val Val Asn Gly  Gly Glu Gln 
    1475                 1480                 1485             


Ala Thr  Glu Glu Leu Ile Gln  Glu Glu Val Glu Ala  Ser Lys Thr 
    1490                 1495                 1500             


Leu Glu  Leu Ile Asp Ile Ser  Ser Lys Asn Ile Met  Glu Glu Lys 
    1505                 1510                 1515             


Arg Met  Asn Gly Ile Ile Tyr  Glu Ile Ile Ser Lys  Arg Leu Ala 
    1520                 1525                 1530             


Thr Pro  Pro Ser Leu Asp Phe  Cys Tyr Asp Ser Lys  Gln Asn Ser 
    1535                 1540                 1545             


Glu Lys  Glu Thr Asn Glu Gly  Glu Thr Lys Met Val  Lys Met Met 
    1550                 1555                 1560             


Val Lys  Thr Met Glu Thr Gly  Ser Tyr Ser Glu Ser  Ser Pro Asp 
    1565                 1570                 1575             


Leu Lys  Lys Cys Ile Lys Ser  Pro Val Thr Ser Asp  Trp Ser Asp 
    1580                 1585                 1590             


Tyr Arg  Pro Asp Ser Asp Ser  Glu Gln Pro Tyr Lys  Thr Ser Ser 
    1595                 1600                 1605             


Asp Asp  Pro Asn Asp Ser Gly  Glu Leu Thr Gln Glu  Lys Glu Tyr 
    1610                 1615                 1620             


Asn Ile  Gly Phe Val Lys Arg  Ala Ile Glu Lys Leu  Tyr Gly Lys 
    1625                 1630                 1635             


Ala Asp  Ile Ile Lys Pro Ser  Phe Phe Pro Gly Ser  Thr Arg Lys 
    1640                 1645                 1650             


Ser Gln  Val Cys Pro Tyr Asn  Ser Val Glu Phe Gln  Cys Ser Arg 
    1655                 1660                 1665             


Lys Ala  Ser Leu Tyr Asp Ser  Glu Gly Gln Ser Phe  Gly Ser Ser 
    1670                 1675                 1680             


Glu Gln  Val Ser Ser Ser Ser  Ser Met Leu Gln Glu  Phe Gln Glu 
    1685                 1690                 1695             


Glu Arg  Gln Asp Lys Cys Asp  Val Ser Ala Val Arg  Asp Asn Tyr 
    1700                 1705                 1710             


Cys Arg  Gly Asp Ile Val Glu  Pro Gly Thr Lys Gln  Asn Asp Asp 
    1715                 1720                 1725             


Ser Arg  Ile Leu Thr Asp Ile  Glu Glu Gly Val Leu  Ile Asp Lys 
    1730                 1735                 1740             


Gly Lys  Trp Leu Leu Lys Glu  Asn His Leu Leu Arg  Met Ser Ser 
    1745                 1750                 1755             


Glu Asn  Pro Gly Met Cys Gly  Asn Ala Asp Thr Thr  Ser Val Asp 
    1760                 1765                 1770             


Thr Leu  Leu Asp Asn Asn Ser  Ser Glu Val Pro Tyr  Ser His Phe 
    1775                 1780                 1785             


Gly Asn  Leu Ala Pro Gly Pro  Thr Met Asp Glu Leu  Ser Ser Ser 
    1790                 1795                 1800             


Glu Leu  Glu Glu Leu Thr Gln  Pro Leu Glu Leu Lys  Cys Asn Tyr 
    1805                 1810                 1815             


Phe Asn  Met Pro His Gly Ser  Asp Ser Glu Pro Phe  His Glu Asp 
    1820                 1825                 1830             


Leu Leu  Asp Val Arg Asn Glu  Thr Cys Ala Lys Glu  Arg Ile Ala 
    1835                 1840                 1845             


Asn His  His Thr Glu Glu Lys  Gly Ser His Gln Ser  Glu Arg Val 
    1850                 1855                 1860             


Cys Thr  Ser Val Thr His Ser  Phe Ile Ser Ala Gly  Asn Lys Val 
    1865                 1870                 1875             


Tyr Pro  Val Ser Asp Asp Ala  Ile Lys Asn Gln Pro  Leu Pro Gly 
    1880                 1885                 1890             


Ser Asn  Met Ile His Gly Thr  Leu Gln Glu Ala Asp  Ser Leu Asp 
    1895                 1900                 1905             


Lys Leu  Tyr Ala Leu Cys Gly  Gln His Cys Pro Ile  Leu Thr Val 
    1910                 1915                 1920             


Ile Ile  Gln Pro Met Asn Glu  Glu Asp Arg Gly Phe  Ala Tyr Arg 
    1925                 1930                 1935             


Lys Glu  Ser Asp Ile Glu Asn  Phe Leu Gly Phe Tyr  Leu Trp Met 
    1940                 1945                 1950             


Lys Ile  His Pro Tyr Leu Leu  Gln Thr Asp Lys Asn  Val Phe Arg 
    1955                 1960                 1965             


Glu Glu  Asn Asn Lys Ala Ser  Met Arg Gln Asn Leu  Ile Asp Asn 
    1970                 1975                 1980             


Ala Ile  Gly Asp Ile Phe Asp  Gln Phe Tyr Phe Ser  Asn Thr Phe 
    1985                 1990                 1995             


Asp Leu  Met Gly Lys Arg Arg  Lys Gln Lys Arg Ile  Asn Phe Leu 
    2000                 2005                 2010             


Gly Leu  Glu Glu Glu Gly Asn  Leu Lys Lys Phe Gln  Pro Asp Leu 
    2015                 2020                 2025             


Lys Glu  Arg Phe Cys Met Asn  Phe Leu His Thr Ser  Leu Leu Val 
    2030                 2035                 2040             


Val Gly  Asn Val Asp Ser Asn  Thr Gln Asp Leu Ser  Gly Gln Thr 
    2045                 2050                 2055             


Asn Glu  Ile Phe Lys Ala Val  Asp Glu Asn Asn Asn  Leu Leu Asn 
    2060                 2065                 2070             


Asn Arg  Phe Gln Gly Ser Arg  Thr Asn Leu Asn Gln  Val Val Arg 
    2075                 2080                 2085             


Glu Asn  Ile Asn Cys His Tyr  Phe Phe Glu Met Leu  Gly Gln Ala 
    2090                 2095                 2100             


Cys Leu  Leu Asp Ile Cys Gln  Val Glu Thr Ser Leu  Asn Ile Ser 
    2105                 2110                 2115             


Asn Arg  Asn Ile Leu Glu Leu  Cys Met Phe Glu Gly  Glu Asn Leu 
    2120                 2125                 2130             


Phe Ile  Trp Glu Glu Glu Asp  Ile Leu Asn Leu Thr  Asp Leu Glu 
    2135                 2140                 2145             


Ser Ser  Arg Glu Gln Glu Asp  Leu 
    2150                 2155     


<210>  36
<211>  3950
<212>  DNA
<213>  Homo sapiens

<400>  36
atgtcacatc tggtggaccc tacatcagga gacttgccag ttagagacat agatgctata       60

cctctggtgc taccagcctc aaaaggtaag aatatgaaaa ctcaaccacc cttgagcagg      120

atgaaccggg aggaattgga ggacagtttc tttcgacttc gcgaagatca catgttggtg      180

aaggagcttt cttggaagca acaggatgag atcaaaaggc tgaggaccac cttgctgcgg      240

ttgaccgctg ctggccggga cctgcgggtc gcggaggagg cggcgccgct ctcggagacc      300

gcaaggcgcg ggcagaaggc gggatggcgg cagcgcctct ccatgcacca gcgcccccag      360

atgcaccgac tgcaagggca tttccactgc gtcggccctg ccagcccccg ccgcgcccag      420

cctcgcgtcc aagtgggaca cagacagctc cacacagccg gtgcaccggt gccggagaaa      480

cccaagaggg ggccaaggga caggctgagc tacacagccc ctccatcgtt taaggagcat      540

gcgacaaatg aaaacagagg tgaagtagcc agtaaaccca gtgaacttgt ttctggttct      600

aacagcataa tttctttcag cagtgtcata agtatggcta aacccattgg tctatgcatg      660

cctaacagtg cccacatcat ggccagcaat accatgcaag tggaagagcc acccaagtct      720

cctgagaaaa tgtggcctaa agatgaaaat tttgaacaga gaagctcatt ggagtgtgct      780

cagaaggctg cagagcttcg agcttccatt aaagagaagg tagagctgat tcgacttaag      840

aagctcttac atgaaagaaa tgcttcattg gttatgacaa aagcacaatt aacagaagtt      900

caagaggcat acgaaacctt gctccagaag aatcagggaa tcctgagtgc agcccatgag      960

gccctcctca agcaagtgaa tgagctcagg gcagagctga aggaagaaag caagaaggct     1020

gtgagcttga agagccaact ggaagatgtg tctatcttgc agatgactct gaaggagttt     1080

caggagagag ttgaagattt ggaaaaagaa cgaaaattgc tgaatgacaa ttatgacaaa     1140

ctcttagaaa gcatgctgga cagcagtgac agctccagtc agccccactg gagcaacgag     1200

ctcatagcgg aacagctaca gcagcaagtc tctcagctgc aggatcagct ggatgctgag     1260

ctggaggaca agagaaaagt tttacttgag ctgtccaggg agaaagccca aaatgaggat     1320

ctgaagcttg aagtcaccaa catacttcag aagcataaac aggaagtaga gctcctccaa     1380

aatgcagcca caatttccca acctcctgac aggcaatctg aaccagccac tcacccagct     1440

gtattgcaag agaacactca gatcgagcca agtgaaccca aaaaccaaga agaaaagaaa     1500

ctgtcccagg tgctaaatga gttgcaagta tcacacgcag agaccacatt ggaactagaa     1560

aagaccaggg acatgcttat tctgcagcgc aaaatcaacg tgtgttatca ggaggaactg     1620

gaggcaatga tgacaaaagc tgacaatgat aatagagatc acaaagaaaa gctggagagg     1680

ttgactcgac tactagacct caagaataac cgtatcaagc agctggaagg tattttaaga     1740

agccatgacc ttccaacatc tgaacagctc aaagatgttg cttatggcac ccgaccgttg     1800

tcgttatgtt tggaaacact gccagcccat ggagatgagg ataaagtgga tatttctctg     1860

ctgcatcagg gtgagaatct ttttgaactg cacatccacc aggccttcct gacatctgcc     1920

gccctagctc aggctggaga tacccaacct accactttct gcacctattc cttctatgac     1980

tttgaaaccc actgtacccc attatctgtg gggccacagc ccctctatga cttcacctcc     2040

cagtatgtga tggagacaga ttcgcttttc ttacactacc ttcaagaggc ttcagcccgg     2100

cttgacatac accaggccat ggccagtgaa cacagcactc ttgctgcagg atggatttgc     2160

tttgacaggg tgctagagac tgtggagaaa gtccatggct tggccacact gattggagct     2220

ggtggagaag agttcggggt tctagagtac tggatgaggc tgcgtttccc cataaaaccc     2280

agcctacagg cgtgcaataa acgaaagaaa gcccaggtct acctgtcaac cgatgtgctt     2340

ggaggccgga aggcccagga agaggagttc agatcggagt cttgggaacc tcagaacgag     2400

ctgtggattg aaatcaccaa gtgctgtggc ctccggagtc gatggctggg aactcaaccc     2460

agtccatatg ctgtgtaccg cttcttcacc ttttctgacc atgacactgc catcattcca     2520

gccagtaaca acccctactt tagagaccag gctcgattcc cagtgcttgt gacctctgac     2580

ctggaccatt atctgagacg ggaggccttg tctatacatg tttttgatga tgaagactta     2640

gagcctggct cgtatcttgg ccgagcccga gtgcctttac tgcctcttgc aaaaaatgaa     2700

tctatcaaag gtgattttaa cctcactgac cctgcagaga aacccaacgg atctattcaa     2760

gtgcaactgg attggaagtt tccctacata ccccctgaga gcttcctgaa accagaagct     2820

cagactaagg ggaaggatac caaggacagt tcaaagatct catctgaaga ggaaaaggct     2880

tcatttcctt cccaggatca gatggcatct cctgaggttc ccattgaagc tggccagtat     2940

cgatctaaga gaaaacctcc tcatggggga gaaagaaagg agaaggagca ccaggttgtg     3000

agctactcaa gaagaaaaca tggcaaaaga ataggtgttc aaggaaagaa tagaatggag     3060

tatcttagcc ttaacatctt aaatggaaat acaccagagc aggtgaatta cactgagtgg     3120

aagttctcag agactaacag cttcataggt gatggcttta aaaatcagca cgaggaagag     3180

gaaatgacat tatcccattc agcactgaaa cagaaggaac ctctacatcc tgtaaatgac     3240

aaagaatcct ctgaacaagg ttctgaagtc agtgaagcac aaactaccga cagtgatgat     3300

gtcatagtgc cacccatgtc tcagaaatat cctaaggcag attcagagaa gatgtgcatt     3360

gaaattgtct ccctggcctt ctacccagag gcagaagtga tgtctgatga gaacataaaa     3420

caggtgtatg tggagtacaa attctacgac ctacccttgt cggagacaga gactccagtg     3480

tccctaagga agcctagggc aggagaagaa atccactttc actttagcaa ggtaatagac     3540

ctggacccac aggagcagca aggccgaagg cggtttctgt tcgacatgct gaatggacaa     3600

gatcctgatc aaggacattt aaagtttaca gtggtaagtg atcctctgga tgaagaaaag     3660

aaagaatgtg aagaagtggg atatgcatat cttcaactgt ggcagatcct ggagtcagga     3720

agagatattc tagagcaaga gctagacatt gttagccctg aagatctggc taccccaata     3780

ggaaggctga aggtttccct tcaagcagct gctgtcctcc atgctattta caaggagatg     3840

actgaagatt tgttttcatg aaggaacaag tgctattcca atctaaaagt ctctgaggga     3900

accatagtaa aaagtctctt ataaagttag cttgctataa catgaaaaaa                3950


<210>  37
<211>  1286
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ser His Leu Val Asp Pro Thr Ser Gly Asp Leu Pro Val Arg Asp 
1               5                   10                  15      


Ile Asp Ala Ile Pro Leu Val Leu Pro Ala Ser Lys Gly Lys Asn Met 
            20                  25                  30          


Lys Thr Gln Pro Pro Leu Ser Arg Met Asn Arg Glu Glu Leu Glu Asp 
        35                  40                  45              


Ser Phe Phe Arg Leu Arg Glu Asp His Met Leu Val Lys Glu Leu Ser 
    50                  55                  60                  


Trp Lys Gln Gln Asp Glu Ile Lys Arg Leu Arg Thr Thr Leu Leu Arg 
65                  70                  75                  80  


Leu Thr Ala Ala Gly Arg Asp Leu Arg Val Ala Glu Glu Ala Ala Pro 
                85                  90                  95      


Leu Ser Glu Thr Ala Arg Arg Gly Gln Lys Ala Gly Trp Arg Gln Arg 
            100                 105                 110         


Leu Ser Met His Gln Arg Pro Gln Met His Arg Leu Gln Gly His Phe 
        115                 120                 125             


His Cys Val Gly Pro Ala Ser Pro Arg Arg Ala Gln Pro Arg Val Gln 
    130                 135                 140                 


Val Gly His Arg Gln Leu His Thr Ala Gly Ala Pro Val Pro Glu Lys 
145                 150                 155                 160 


Pro Lys Arg Gly Pro Arg Asp Arg Leu Ser Tyr Thr Ala Pro Pro Ser 
                165                 170                 175     


Phe Lys Glu His Ala Thr Asn Glu Asn Arg Gly Glu Val Ala Ser Lys 
            180                 185                 190         


Pro Ser Glu Leu Val Ser Gly Ser Asn Ser Ile Ile Ser Phe Ser Ser 
        195                 200                 205             


Val Ile Ser Met Ala Lys Pro Ile Gly Leu Cys Met Pro Asn Ser Ala 
    210                 215                 220                 


His Ile Met Ala Ser Asn Thr Met Gln Val Glu Glu Pro Pro Lys Ser 
225                 230                 235                 240 


Pro Glu Lys Met Trp Pro Lys Asp Glu Asn Phe Glu Gln Arg Ser Ser 
                245                 250                 255     


Leu Glu Cys Ala Gln Lys Ala Ala Glu Leu Arg Ala Ser Ile Lys Glu 
            260                 265                 270         


Lys Val Glu Leu Ile Arg Leu Lys Lys Leu Leu His Glu Arg Asn Ala 
        275                 280                 285             


Ser Leu Val Met Thr Lys Ala Gln Leu Thr Glu Val Gln Glu Ala Tyr 
    290                 295                 300                 


Glu Thr Leu Leu Gln Lys Asn Gln Gly Ile Leu Ser Ala Ala His Glu 
305                 310                 315                 320 


Ala Leu Leu Lys Gln Val Asn Glu Leu Arg Ala Glu Leu Lys Glu Glu 
                325                 330                 335     


Ser Lys Lys Ala Val Ser Leu Lys Ser Gln Leu Glu Asp Val Ser Ile 
            340                 345                 350         


Leu Gln Met Thr Leu Lys Glu Phe Gln Glu Arg Val Glu Asp Leu Glu 
        355                 360                 365             


Lys Glu Arg Lys Leu Leu Asn Asp Asn Tyr Asp Lys Leu Leu Glu Ser 
    370                 375                 380                 


Met Leu Asp Ser Ser Asp Ser Ser Ser Gln Pro His Trp Ser Asn Glu 
385                 390                 395                 400 


Leu Ile Ala Glu Gln Leu Gln Gln Gln Val Ser Gln Leu Gln Asp Gln 
                405                 410                 415     


Leu Asp Ala Glu Leu Glu Asp Lys Arg Lys Val Leu Leu Glu Leu Ser 
            420                 425                 430         


Arg Glu Lys Ala Gln Asn Glu Asp Leu Lys Leu Glu Val Thr Asn Ile 
        435                 440                 445             


Leu Gln Lys His Lys Gln Glu Val Glu Leu Leu Gln Asn Ala Ala Thr 
    450                 455                 460                 


Ile Ser Gln Pro Pro Asp Arg Gln Ser Glu Pro Ala Thr His Pro Ala 
465                 470                 475                 480 


Val Leu Gln Glu Asn Thr Gln Ile Glu Pro Ser Glu Pro Lys Asn Gln 
                485                 490                 495     


Glu Glu Lys Lys Leu Ser Gln Val Leu Asn Glu Leu Gln Val Ser His 
            500                 505                 510         


Ala Glu Thr Thr Leu Glu Leu Glu Lys Thr Arg Asp Met Leu Ile Leu 
        515                 520                 525             


Gln Arg Lys Ile Asn Val Cys Tyr Gln Glu Glu Leu Glu Ala Met Met 
    530                 535                 540                 


Thr Lys Ala Asp Asn Asp Asn Arg Asp His Lys Glu Lys Leu Glu Arg 
545                 550                 555                 560 


Leu Thr Arg Leu Leu Asp Leu Lys Asn Asn Arg Ile Lys Gln Leu Glu 
                565                 570                 575     


Gly Ile Leu Arg Ser His Asp Leu Pro Thr Ser Glu Gln Leu Lys Asp 
            580                 585                 590         


Val Ala Tyr Gly Thr Arg Pro Leu Ser Leu Cys Leu Glu Thr Leu Pro 
        595                 600                 605             


Ala His Gly Asp Glu Asp Lys Val Asp Ile Ser Leu Leu His Gln Gly 
    610                 615                 620                 


Glu Asn Leu Phe Glu Leu His Ile His Gln Ala Phe Leu Thr Ser Ala 
625                 630                 635                 640 


Ala Leu Ala Gln Ala Gly Asp Thr Gln Pro Thr Thr Phe Cys Thr Tyr 
                645                 650                 655     


Ser Phe Tyr Asp Phe Glu Thr His Cys Thr Pro Leu Ser Val Gly Pro 
            660                 665                 670         


Gln Pro Leu Tyr Asp Phe Thr Ser Gln Tyr Val Met Glu Thr Asp Ser 
        675                 680                 685             


Leu Phe Leu His Tyr Leu Gln Glu Ala Ser Ala Arg Leu Asp Ile His 
    690                 695                 700                 


Gln Ala Met Ala Ser Glu His Ser Thr Leu Ala Ala Gly Trp Ile Cys 
705                 710                 715                 720 


Phe Asp Arg Val Leu Glu Thr Val Glu Lys Val His Gly Leu Ala Thr 
                725                 730                 735     


Leu Ile Gly Ala Gly Gly Glu Glu Phe Gly Val Leu Glu Tyr Trp Met 
            740                 745                 750         


Arg Leu Arg Phe Pro Ile Lys Pro Ser Leu Gln Ala Cys Asn Lys Arg 
        755                 760                 765             


Lys Lys Ala Gln Val Tyr Leu Ser Thr Asp Val Leu Gly Gly Arg Lys 
    770                 775                 780                 


Ala Gln Glu Glu Glu Phe Arg Ser Glu Ser Trp Glu Pro Gln Asn Glu 
785                 790                 795                 800 


Leu Trp Ile Glu Ile Thr Lys Cys Cys Gly Leu Arg Ser Arg Trp Leu 
                805                 810                 815     


Gly Thr Gln Pro Ser Pro Tyr Ala Val Tyr Arg Phe Phe Thr Phe Ser 
            820                 825                 830         


Asp His Asp Thr Ala Ile Ile Pro Ala Ser Asn Asn Pro Tyr Phe Arg 
        835                 840                 845             


Asp Gln Ala Arg Phe Pro Val Leu Val Thr Ser Asp Leu Asp His Tyr 
    850                 855                 860                 


Leu Arg Arg Glu Ala Leu Ser Ile His Val Phe Asp Asp Glu Asp Leu 
865                 870                 875                 880 


Glu Pro Gly Ser Tyr Leu Gly Arg Ala Arg Val Pro Leu Leu Pro Leu 
                885                 890                 895     


Ala Lys Asn Glu Ser Ile Lys Gly Asp Phe Asn Leu Thr Asp Pro Ala 
            900                 905                 910         


Glu Lys Pro Asn Gly Ser Ile Gln Val Gln Leu Asp Trp Lys Phe Pro 
        915                 920                 925             


Tyr Ile Pro Pro Glu Ser Phe Leu Lys Pro Glu Ala Gln Thr Lys Gly 
    930                 935                 940                 


Lys Asp Thr Lys Asp Ser Ser Lys Ile Ser Ser Glu Glu Glu Lys Ala 
945                 950                 955                 960 


Ser Phe Pro Ser Gln Asp Gln Met Ala Ser Pro Glu Val Pro Ile Glu 
                965                 970                 975     


Ala Gly Gln Tyr Arg Ser Lys Arg Lys Pro Pro His Gly Gly Glu Arg 
            980                 985                 990         


Lys Glu Lys Glu His Gln Val Val  Ser Tyr Ser Arg Arg  Lys His Gly 
        995                 1000                 1005             


Lys Arg  Ile Gly Val Gln Gly  Lys Asn Arg Met Glu  Tyr Leu Ser 
    1010                 1015                 1020             


Leu Asn  Ile Leu Asn Gly Asn  Thr Pro Glu Gln Val  Asn Tyr Thr 
    1025                 1030                 1035             


Glu Trp  Lys Phe Ser Glu Thr  Asn Ser Phe Ile Gly  Asp Gly Phe 
    1040                 1045                 1050             


Lys Asn  Gln His Glu Glu Glu  Glu Met Thr Leu Ser  His Ser Ala 
    1055                 1060                 1065             


Leu Lys  Gln Lys Glu Pro Leu  His Pro Val Asn Asp  Lys Glu Ser 
    1070                 1075                 1080             


Ser Glu  Gln Gly Ser Glu Val  Ser Glu Ala Gln Thr  Thr Asp Ser 
    1085                 1090                 1095             


Asp Asp  Val Ile Val Pro Pro  Met Ser Gln Lys Tyr  Pro Lys Ala 
    1100                 1105                 1110             


Asp Ser  Glu Lys Met Cys Ile  Glu Ile Val Ser Leu  Ala Phe Tyr 
    1115                 1120                 1125             


Pro Glu  Ala Glu Val Met Ser  Asp Glu Asn Ile Lys  Gln Val Tyr 
    1130                 1135                 1140             


Val Glu  Tyr Lys Phe Tyr Asp  Leu Pro Leu Ser Glu  Thr Glu Thr 
    1145                 1150                 1155             


Pro Val  Ser Leu Arg Lys Pro  Arg Ala Gly Glu Glu  Ile His Phe 
    1160                 1165                 1170             


His Phe  Ser Lys Val Ile Asp  Leu Asp Pro Gln Glu  Gln Gln Gly 
    1175                 1180                 1185             


Arg Arg  Arg Phe Leu Phe Asp  Met Leu Asn Gly Gln  Asp Pro Asp 
    1190                 1195                 1200             


Gln Gly  His Leu Lys Phe Thr  Val Val Ser Asp Pro  Leu Asp Glu 
    1205                 1210                 1215             


Glu Lys  Lys Glu Cys Glu Glu  Val Gly Tyr Ala Tyr  Leu Gln Leu 
    1220                 1225                 1230             


Trp Gln  Ile Leu Glu Ser Gly  Arg Asp Ile Leu Glu  Gln Glu Leu 
    1235                 1240                 1245             


Asp Ile  Val Ser Pro Glu Asp  Leu Ala Thr Pro Ile  Gly Arg Leu 
    1250                 1255                 1260             


Lys Val  Ser Leu Gln Ala Ala  Ala Val Leu His Ala  Ile Tyr Lys 
    1265                 1270                 1275             


Glu Met  Thr Glu Asp Leu Phe  Ser 
    1280                 1285     


<210>  38
<211>  7221
<212>  DNA
<213>  Homo sapiens

<400>  38
cgggcggcct cttgtgtgag ggcctgtggg attctccgga tatggccgga gtgtttcctt       60

atcgagggcc gggtaacccg gtgcctggcc ctctagcccc gctaccggac tacatgtcgg      120

aggagaagct gcaggagaaa gctcgaaaat ggcagcaatt gcaggccaag cgctatgcag      180

aaaagcggaa gtttgggttt gtggatgccc agaaggaaga catgccccca gaacatgtca      240

gggagatcat tcgagaccat ggagacatga ccaacaggaa gttccgccat gacaaaaggg      300

tttacttggg tgccctaaag tacatgcccc acgcagtcct caaactcctg gagaacatgc      360

ctatgccttg ggagcagatt cgggatgtgc ccgtgctgta ccacatcact ggagccattt      420

ccttcgtcaa tgagattccc tgggtcattg aacctgtcta catctcccag tgggggtcaa      480

tgtggattat gatgcgccga gaaaaaagag ataggaggca tttcaagaga atgcgttttc      540

ccccttttga tgatgaggag ccgcccttgg actatgctga caacatccta aatgttgagc      600

cactggaggc cattcagcta gagctggacc ctgaggagga cgcccctgtg ttggactggt      660

tctatgacca ccagccgttg agggacagca ggaagtatgt aaatggctcc acttaccagc      720

gctggcagtt cacactacct atgatgtcaa ctctctaccg cctggctaat cagctcctga      780

cagacttggt ggatgacaac tacttctacc tgtttgattt gaaggccttc tttacgtcca      840

aggcactcaa tatggccatt cctggaggcc ccaaatttga acctcttgtt cgagacatca      900

acctacagga tgaagactgg aatgaattca atgatattaa caagattatc atccggcagc      960

ctatccggac tgagtacaag attgcttttc cttacttgta caacaatctt ccacaccatg     1020

tccacctcac ctggtaccat actcccaatg ttgtattcat caaaactgaa gatcctgact     1080

tgccagcttt ctactttgac cctttgatca acccaatctc ccataggcac tcagtcaaga     1140

gccaggaacc attgccggat gatgatgagg aatttgagct cccggagttt gtggagccct     1200

tcctgaagga cacacccctc tatacagaca atacagccaa tggcattgcc ctgctctggg     1260

ccccgcggcc cttcaaccta cgctctggtc gcacccgtcg ggccctggac ataccccttg     1320

tcaagaactg gtatcgggag cattgtcctg ccgggcagcc tgtgaaagtg agggtctcct     1380

accagaagct gcttaagtac tatgtgctga atgccctgaa gcatcggccc cctaaggctc     1440

aaaagaagag gtatttgttc cgctccttca aagccaccaa attctttcag tccacaaagc     1500

tggactgggt ggagggttgg ctccaggttt gccgccaggg ctacaacatg ctcaaccttc     1560

tcattcaccg caaaaacctc aactacctgc acctggacta caacttcaac ctcaagcctg     1620

tgaaaacgct caccaccaag gaaagaaaga aatctcgttt tgggaatgct ttccacctgt     1680

gtcgggaagt tctgcgtttg actaagctgg tggtggatag tcacgtgcag tatcggctgg     1740

gcaatgtgga tgccttccag ctggcagatg gattgcagta tatatttgcc catgttgggc     1800

agttgacggg catgtatcga tacaaataca agctgatgcg acagattcgc gtgtgcaagg     1860

acctgaagca tctcatctat tatcgtttca acacaggccc tgtagggaag ggtcctggct     1920

gtggcttctg ggctgccggt tggcgagtct ggctcttttt catgcgtggc attacccctt     1980

tattagagcg atggcttggc aacctcctgg cccggcagtt tgaaggtcga cactcaaagg     2040

gggtggcaaa gacagtaaca aagcagcgag tggagtcaca ttttgacctt gagctgcggg     2100

cagctgtgat gcatgatatt ctggacatga tgcctgaggg gatcaagcag aacaaggccc     2160

ggacaatcct gcagcacctc agtgaagcct ggcgctgctg gaaagccaac attccctgga     2220

aggtccctgg gctgccgacg cccatagaga atatgatcct tcgatacgtg aaggccaagg     2280

ctgactggtg gaccaacact gcccactaca accgagaacg gatccgccga ggggccactg     2340

tggacaagac tgtttgtaaa aagaatctgg gccgcctcac ccggctctat ctgaaggcag     2400

aacaggagcg gcagcacaac tacctgaagg acgggcctta catcacagcg gaggaaacag     2460

tggcagtata taccaccaca gtgcattggt tggaaagccg caggttttca cccatcccat     2520

tccccccact ctcctataag catgacacca agttgctcat cttggcattg gagcggctca     2580

aggaagctta tagtgtgaag tctcggttga accagtctca gagggaggag ctaggtctga     2640

tcgagcaggc ctacgataac ctccacgagg cgctgtcccg cataaagcgt cacctcctca     2700

cacagagagc cttcaaagag gtgggcattg agttcatgga tctgtatagc cacctcgttc     2760

cagtatatga tgttgagccc ctggagaaga taactgatgc ttacctggac cagtacctgt     2820

ggtatgaagc cgacaagcgc cgcctgttcc caccctggat taagcctgca gacacagaac     2880

cacctccact gcttgtttac aagtggtgtc aaggcatcaa taacctgcag gacgtgtggg     2940

agacgagtga aggcgagtgc aatgtcatgc tggaatcccg ctttgagaag atgtatgaga     3000

agatcgactt gactctgctc aacaggctcg tgcgcctcat cgtggaccac aacatagccg     3060

actacatgac agccaagaac aacgtcgtca tcaactataa ggacatgaac catacgaatt     3120

catatgggat catcagaggc ctgcagtttg cctcattcat agtgcagtat tatggcctgg     3180

tgatggattt gcttgtattg ggattgcacc gggccagtga gatggctggg ccccctcaga     3240

tgccaaatga ctttctcagt ttccaggaca tagccactga ggctgcccac cccatccgtc     3300

tcttctgcag atacattgat cgcatccata tttttttcag gttcacagca gatgaggctc     3360

gggacctgat tcaacgttac ctgacagagc accctgaccc caataatgaa aacatcgttg     3420

gctataataa caagaagtgc tggccccgag atgcccgcat gcgcctcatg aaacatgatg     3480

ttaacttagg ccgggcggta ttctgggaca tcaagaaccg cttgccacgg tcagtgacta     3540

cagttcagtg ggagaacagc ttcgtgtctg tgtacagtaa ggacaacccc aacctgctgt     3600

tcaacatgtg tggcttcgag tgccgcatcc tgcctaagtg ccgcaccagc tatgaggagt     3660

tcacccacaa ggacggggtc tggaacctgc agaatgaggt tactaaggag cgcacagctc     3720

agtgtttcct gcgtgtggac gatgagtcaa tgcagcgctt ccacaaccgc gtgcgtcaga     3780

ttctcatggc ctctgggtcc accaccttca ccaagattgt gaataagtgg aatacagctc     3840

tcattggcct tatgacatac tttcgggagg ctgtggtgaa cacccaagag ctcttggact     3900

tactggtgaa gtgtgagcac aaaatccaga cacgtatcaa gattggactc aactccaaga     3960

tgccaagtcg gttccccccg gttgtgttct acacccctaa ggagttgggt ggactcggca     4020

tgctctcaat gggccatgtg ctcatccccc aatccgacct caggtggtcc aaacagacag     4080

atgtaggtat cacacacttt cgttcaggaa tgagccatga agaagaccag ctcattccca     4140

acttgtaccg ctacatacag ccatgggaga gcgagttcat tgattctcag cgggtctggg     4200

ctgagtactc actcaagaga caagaggcca ttgctcagaa cagacgcctg actttagaag     4260

acctagaaga ttcatgggat cgtggcattc ctcgaatcaa taccctcttc cagaaggacc     4320

ggcacacact ggcttatgat aagggctggc gtgtcagaac tgactttaag cagtatcagg     4380

ttttgaagca gaatccgttc tggtggacac accagcggca tgatgggaag ctctggaacc     4440

tgaacaacta ccgtacagac atgatccagg ccctgggcgg tgtggaaggc attctggaac     4500

acacactctt taagggcact tacttcccta cctgggaggg gcttttctgg gagaaggcca     4560

gtggctttga ggaatctatg aagtggaaga agctaactaa tgctcagcga tcaggactga     4620

accagattcc caatcgtaga ttcaccctct ggtggtcccc gaccattaat cgagccaatg     4680

tatatgtagg ctttcaggtg cagctagacc tgacgggtat cttcatgcac ggcaagatcc     4740

ccacgctgaa gatctctctc atccagatct tccgagctca cttgtggcag aagatccatg     4800

agagcattgt tatggactta tgtcaggtgt ttgaccagga acttgatgca ctggaaattg     4860

agacagtaca aaaggagaca atccatcccc gaaagtcata taagatgaac tcttcctgtg     4920

cagatatcct gctctttgcc tcctataagt ggaatgtctc ccggccctca ttgctggctg     4980

actccaagga tgtgatggac agcaccacca cccagaaata ctggattgac atccagttgc     5040

gctgggggga ctatgattcc cacgacattg agcgctacgc ccgggccaag ttcctggact     5100

acaccaccga caacatgagt atctaccctt cgcccacagg tgtactcatc gccattgacc     5160

tggcctataa cttgcacagt gcctatggaa actggttccc aggcagcaag cctctcatac     5220

aacaggccat ggccaagatc atgaaggcaa accctgccct gtatgtgtta cgtgaacgga     5280

tccgcaaggg gctacagctc tattcatctg aacccactga gccttatttg tcttctcaga     5340

actatggtga gctcttctcc aaccagatta tctggtttgt ggatgacacc aacgtctaca     5400

gagtgactat tcacaagacc tttgaaggga acttgacaac caagcccatc aacggagcca     5460

tcttcatctt caacccacgc acagggcagc tgttcctcaa gataatccac acgtccgtgt     5520

gggcgggaca gaagcgtttg gggcagttgg ctaagtggaa gacagctgag gaggtggccg     5580

ccctgatccg atctctgcct gtggaggagc agcccaagca gatcattgtc accaggaagg     5640

acatgctgga cccactggag gtgcacttac tggacttccc caatattgtc atcaaaggat     5700

cggagctcca actccctttc caggcgtgtc tcaaggtgga aaaattcggg gatctcatcc     5760

ttaaagccac tgagccccag atggttctct tcaacctcta tgacgactgg ctcaagacta     5820

tttcatctta cacggccttc tcccgtctca tcctgattct gcgtgcccta catgtgaaca     5880

acgatcgggc aaaagtgatc ctgaagccag acaagactac tattacagaa ccacaccaca     5940

tctggcccac tctgactgac gaagaatgga tcaaggtcga ggtgcagctc aaggatctga     6000

tcttggctga ctacggcaag aaaaacaatg tgaacgtggc atcactgaca caatcagaaa     6060

ttcgagacat catcctgggt atggagatct cggcaccgtc acagcagcgg cagcagatcg     6120

ctgagatcga gaagcagacc aaggaacaat cgcagctgac ggcaacacag actcgcactg     6180

tcaacaagca tggcgatgag atcatcacct ccaccaccag caactatgag acccagactt     6240

tctcatccaa gactgagtgg agggtcaggg ccatctctgc tgccaacctg cacctaagga     6300

ccaatcacat ctatgtttca tctgacgaca tcaaggagac tggctacacc tacatccttc     6360

ccaagaatgt gcttaagaag ttcatctgca tatctgacct tcgggcccaa attgcaggat     6420

acctatatgg ggtgagccca ccagataacc cccaggtgaa ggagatccgc tgcattgtga     6480

tggtgccgca gtggggcact caccagaccg tgcacctgcc tggccagctg ccccagcatg     6540

agtacctcaa ggagatggaa cccttaggtt ggatccacac tcagcccaat gagtccccgc     6600

agttatcacc ccaggatgtc accacccatg ccaagatcat ggctgacaac ccatcttggg     6660

atggcgagaa gaccattatc atcacatgca gcttcacgcc aggctcctgt acactgacgg     6720

cctacaagct gacccctagt ggctacgaat ggggccgcca gaacacagac aagggcaaca     6780

accccaaggg ctacctgcct tcacactatg agagggtgca gatgctgctg tcggaccgtt     6840

tccttggctt cttcatggtc cctgcccagt cctcgtggaa ctacaacttc atgggtgttc     6900

ggcatgaccc caacatgaaa tatgagctac agctggcgaa ccccaaagag ttctaccacg     6960

aggtgcacag gccctctcac ttcctcaact ttgctctcct gcaggagggg gaggtttact     7020

ctgcggatcg ggaggacctg tatgcctgac cgtttccctg cctcctgctt cagcctcccg     7080

aggccgaagc ctcagcccct ccagacaggc cgctgacatt cagcagtttg gcctctttcc     7140

ctctgtctgt gcttgtgttg ttgacctcct gatggcttgt catcctgaat aaaatataat     7200

aataaatttt gtataaatag g                                               7221


<210>  39
<211>  2335
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Gly Val Phe Pro Tyr Arg Gly Pro Gly Asn Pro Val Pro Gly 
1               5                   10                  15      


Pro Leu Ala Pro Leu Pro Asp Tyr Met Ser Glu Glu Lys Leu Gln Glu 
            20                  25                  30          


Lys Ala Arg Lys Trp Gln Gln Leu Gln Ala Lys Arg Tyr Ala Glu Lys 
        35                  40                  45              


Arg Lys Phe Gly Phe Val Asp Ala Gln Lys Glu Asp Met Pro Pro Glu 
    50                  55                  60                  


His Val Arg Glu Ile Ile Arg Asp His Gly Asp Met Thr Asn Arg Lys 
65                  70                  75                  80  


Phe Arg His Asp Lys Arg Val Tyr Leu Gly Ala Leu Lys Tyr Met Pro 
                85                  90                  95      


His Ala Val Leu Lys Leu Leu Glu Asn Met Pro Met Pro Trp Glu Gln 
            100                 105                 110         


Ile Arg Asp Val Pro Val Leu Tyr His Ile Thr Gly Ala Ile Ser Phe 
        115                 120                 125             


Val Asn Glu Ile Pro Trp Val Ile Glu Pro Val Tyr Ile Ser Gln Trp 
    130                 135                 140                 


Gly Ser Met Trp Ile Met Met Arg Arg Glu Lys Arg Asp Arg Arg His 
145                 150                 155                 160 


Phe Lys Arg Met Arg Phe Pro Pro Phe Asp Asp Glu Glu Pro Pro Leu 
                165                 170                 175     


Asp Tyr Ala Asp Asn Ile Leu Asn Val Glu Pro Leu Glu Ala Ile Gln 
            180                 185                 190         


Leu Glu Leu Asp Pro Glu Glu Asp Ala Pro Val Leu Asp Trp Phe Tyr 
        195                 200                 205             


Asp His Gln Pro Leu Arg Asp Ser Arg Lys Tyr Val Asn Gly Ser Thr 
    210                 215                 220                 


Tyr Gln Arg Trp Gln Phe Thr Leu Pro Met Met Ser Thr Leu Tyr Arg 
225                 230                 235                 240 


Leu Ala Asn Gln Leu Leu Thr Asp Leu Val Asp Asp Asn Tyr Phe Tyr 
                245                 250                 255     


Leu Phe Asp Leu Lys Ala Phe Phe Thr Ser Lys Ala Leu Asn Met Ala 
            260                 265                 270         


Ile Pro Gly Gly Pro Lys Phe Glu Pro Leu Val Arg Asp Ile Asn Leu 
        275                 280                 285             


Gln Asp Glu Asp Trp Asn Glu Phe Asn Asp Ile Asn Lys Ile Ile Ile 
    290                 295                 300                 


Arg Gln Pro Ile Arg Thr Glu Tyr Lys Ile Ala Phe Pro Tyr Leu Tyr 
305                 310                 315                 320 


Asn Asn Leu Pro His His Val His Leu Thr Trp Tyr His Thr Pro Asn 
                325                 330                 335     


Val Val Phe Ile Lys Thr Glu Asp Pro Asp Leu Pro Ala Phe Tyr Phe 
            340                 345                 350         


Asp Pro Leu Ile Asn Pro Ile Ser His Arg His Ser Val Lys Ser Gln 
        355                 360                 365             


Glu Pro Leu Pro Asp Asp Asp Glu Glu Phe Glu Leu Pro Glu Phe Val 
    370                 375                 380                 


Glu Pro Phe Leu Lys Asp Thr Pro Leu Tyr Thr Asp Asn Thr Ala Asn 
385                 390                 395                 400 


Gly Ile Ala Leu Leu Trp Ala Pro Arg Pro Phe Asn Leu Arg Ser Gly 
                405                 410                 415     


Arg Thr Arg Arg Ala Leu Asp Ile Pro Leu Val Lys Asn Trp Tyr Arg 
            420                 425                 430         


Glu His Cys Pro Ala Gly Gln Pro Val Lys Val Arg Val Ser Tyr Gln 
        435                 440                 445             


Lys Leu Leu Lys Tyr Tyr Val Leu Asn Ala Leu Lys His Arg Pro Pro 
    450                 455                 460                 


Lys Ala Gln Lys Lys Arg Tyr Leu Phe Arg Ser Phe Lys Ala Thr Lys 
465                 470                 475                 480 


Phe Phe Gln Ser Thr Lys Leu Asp Trp Val Glu Gly Trp Leu Gln Val 
                485                 490                 495     


Cys Arg Gln Gly Tyr Asn Met Leu Asn Leu Leu Ile His Arg Lys Asn 
            500                 505                 510         


Leu Asn Tyr Leu His Leu Asp Tyr Asn Phe Asn Leu Lys Pro Val Lys 
        515                 520                 525             


Thr Leu Thr Thr Lys Glu Arg Lys Lys Ser Arg Phe Gly Asn Ala Phe 
    530                 535                 540                 


His Leu Cys Arg Glu Val Leu Arg Leu Thr Lys Leu Val Val Asp Ser 
545                 550                 555                 560 


His Val Gln Tyr Arg Leu Gly Asn Val Asp Ala Phe Gln Leu Ala Asp 
                565                 570                 575     


Gly Leu Gln Tyr Ile Phe Ala His Val Gly Gln Leu Thr Gly Met Tyr 
            580                 585                 590         


Arg Tyr Lys Tyr Lys Leu Met Arg Gln Ile Arg Val Cys Lys Asp Leu 
        595                 600                 605             


Lys His Leu Ile Tyr Tyr Arg Phe Asn Thr Gly Pro Val Gly Lys Gly 
    610                 615                 620                 


Pro Gly Cys Gly Phe Trp Ala Ala Gly Trp Arg Val Trp Leu Phe Phe 
625                 630                 635                 640 


Met Arg Gly Ile Thr Pro Leu Leu Glu Arg Trp Leu Gly Asn Leu Leu 
                645                 650                 655     


Ala Arg Gln Phe Glu Gly Arg His Ser Lys Gly Val Ala Lys Thr Val 
            660                 665                 670         


Thr Lys Gln Arg Val Glu Ser His Phe Asp Leu Glu Leu Arg Ala Ala 
        675                 680                 685             


Val Met His Asp Ile Leu Asp Met Met Pro Glu Gly Ile Lys Gln Asn 
    690                 695                 700                 


Lys Ala Arg Thr Ile Leu Gln His Leu Ser Glu Ala Trp Arg Cys Trp 
705                 710                 715                 720 


Lys Ala Asn Ile Pro Trp Lys Val Pro Gly Leu Pro Thr Pro Ile Glu 
                725                 730                 735     


Asn Met Ile Leu Arg Tyr Val Lys Ala Lys Ala Asp Trp Trp Thr Asn 
            740                 745                 750         


Thr Ala His Tyr Asn Arg Glu Arg Ile Arg Arg Gly Ala Thr Val Asp 
        755                 760                 765             


Lys Thr Val Cys Lys Lys Asn Leu Gly Arg Leu Thr Arg Leu Tyr Leu 
    770                 775                 780                 


Lys Ala Glu Gln Glu Arg Gln His Asn Tyr Leu Lys Asp Gly Pro Tyr 
785                 790                 795                 800 


Ile Thr Ala Glu Glu Thr Val Ala Val Tyr Thr Thr Thr Val His Trp 
                805                 810                 815     


Leu Glu Ser Arg Arg Phe Ser Pro Ile Pro Phe Pro Pro Leu Ser Tyr 
            820                 825                 830         


Lys His Asp Thr Lys Leu Leu Ile Leu Ala Leu Glu Arg Leu Lys Glu 
        835                 840                 845             


Ala Tyr Ser Val Lys Ser Arg Leu Asn Gln Ser Gln Arg Glu Glu Leu 
    850                 855                 860                 


Gly Leu Ile Glu Gln Ala Tyr Asp Asn Leu His Glu Ala Leu Ser Arg 
865                 870                 875                 880 


Ile Lys Arg His Leu Leu Thr Gln Arg Ala Phe Lys Glu Val Gly Ile 
                885                 890                 895     


Glu Phe Met Asp Leu Tyr Ser His Leu Val Pro Val Tyr Asp Val Glu 
            900                 905                 910         


Pro Leu Glu Lys Ile Thr Asp Ala Tyr Leu Asp Gln Tyr Leu Trp Tyr 
        915                 920                 925             


Glu Ala Asp Lys Arg Arg Leu Phe Pro Pro Trp Ile Lys Pro Ala Asp 
    930                 935                 940                 


Thr Glu Pro Pro Pro Leu Leu Val Tyr Lys Trp Cys Gln Gly Ile Asn 
945                 950                 955                 960 


Asn Leu Gln Asp Val Trp Glu Thr Ser Glu Gly Glu Cys Asn Val Met 
                965                 970                 975     


Leu Glu Ser Arg Phe Glu Lys Met Tyr Glu Lys Ile Asp Leu Thr Leu 
            980                 985                 990         


Leu Asn Arg Leu Val Arg Leu Ile  Val Asp His Asn Ile  Ala Asp Tyr 
        995                 1000                 1005             


Met Thr  Ala Lys Asn Asn Val  Val Ile Asn Tyr Lys  Asp Met Asn 
    1010                 1015                 1020             


His Thr  Asn Ser Tyr Gly Ile  Ile Arg Gly Leu Gln  Phe Ala Ser 
    1025                 1030                 1035             


Phe Ile  Val Gln Tyr Tyr Gly  Leu Val Met Asp Leu  Leu Val Leu 
    1040                 1045                 1050             


Gly Leu  His Arg Ala Ser Glu  Met Ala Gly Pro Pro  Gln Met Pro 
    1055                 1060                 1065             


Asn Asp  Phe Leu Ser Phe Gln  Asp Ile Ala Thr Glu  Ala Ala His 
    1070                 1075                 1080             


Pro Ile  Arg Leu Phe Cys Arg  Tyr Ile Asp Arg Ile  His Ile Phe 
    1085                 1090                 1095             


Phe Arg  Phe Thr Ala Asp Glu  Ala Arg Asp Leu Ile  Gln Arg Tyr 
    1100                 1105                 1110             


Leu Thr  Glu His Pro Asp Pro  Asn Asn Glu Asn Ile  Val Gly Tyr 
    1115                 1120                 1125             


Asn Asn  Lys Lys Cys Trp Pro  Arg Asp Ala Arg Met  Arg Leu Met 
    1130                 1135                 1140             


Lys His  Asp Val Asn Leu Gly  Arg Ala Val Phe Trp  Asp Ile Lys 
    1145                 1150                 1155             


Asn Arg  Leu Pro Arg Ser Val  Thr Thr Val Gln Trp  Glu Asn Ser 
    1160                 1165                 1170             


Phe Val  Ser Val Tyr Ser Lys  Asp Asn Pro Asn Leu  Leu Phe Asn 
    1175                 1180                 1185             


Met Cys  Gly Phe Glu Cys Arg  Ile Leu Pro Lys Cys  Arg Thr Ser 
    1190                 1195                 1200             


Tyr Glu  Glu Phe Thr His Lys  Asp Gly Val Trp Asn  Leu Gln Asn 
    1205                 1210                 1215             


Glu Val  Thr Lys Glu Arg Thr  Ala Gln Cys Phe Leu  Arg Val Asp 
    1220                 1225                 1230             


Asp Glu  Ser Met Gln Arg Phe  His Asn Arg Val Arg  Gln Ile Leu 
    1235                 1240                 1245             


Met Ala  Ser Gly Ser Thr Thr  Phe Thr Lys Ile Val  Asn Lys Trp 
    1250                 1255                 1260             


Asn Thr  Ala Leu Ile Gly Leu  Met Thr Tyr Phe Arg  Glu Ala Val 
    1265                 1270                 1275             


Val Asn  Thr Gln Glu Leu Leu  Asp Leu Leu Val Lys  Cys Glu His 
    1280                 1285                 1290             


Lys Ile  Gln Thr Arg Ile Lys  Ile Gly Leu Asn Ser  Lys Met Pro 
    1295                 1300                 1305             


Ser Arg  Phe Pro Pro Val Val  Phe Tyr Thr Pro Lys  Glu Leu Gly 
    1310                 1315                 1320             


Gly Leu  Gly Met Leu Ser Met  Gly His Val Leu Ile  Pro Gln Ser 
    1325                 1330                 1335             


Asp Leu  Arg Trp Ser Lys Gln  Thr Asp Val Gly Ile  Thr His Phe 
    1340                 1345                 1350             


Arg Ser  Gly Met Ser His Glu  Glu Asp Gln Leu Ile  Pro Asn Leu 
    1355                 1360                 1365             


Tyr Arg  Tyr Ile Gln Pro Trp  Glu Ser Glu Phe Ile  Asp Ser Gln 
    1370                 1375                 1380             


Arg Val  Trp Ala Glu Tyr Ser  Leu Lys Arg Gln Glu  Ala Ile Ala 
    1385                 1390                 1395             


Gln Asn  Arg Arg Leu Thr Leu  Glu Asp Leu Glu Asp  Ser Trp Asp 
    1400                 1405                 1410             


Arg Gly  Ile Pro Arg Ile Asn  Thr Leu Phe Gln Lys  Asp Arg His 
    1415                 1420                 1425             


Thr Leu  Ala Tyr Asp Lys Gly  Trp Arg Val Arg Thr  Asp Phe Lys 
    1430                 1435                 1440             


Gln Tyr  Gln Val Leu Lys Gln  Asn Pro Phe Trp Trp  Thr His Gln 
    1445                 1450                 1455             


Arg His  Asp Gly Lys Leu Trp  Asn Leu Asn Asn Tyr  Arg Thr Asp 
    1460                 1465                 1470             


Met Ile  Gln Ala Leu Gly Gly  Val Glu Gly Ile Leu  Glu His Thr 
    1475                 1480                 1485             


Leu Phe  Lys Gly Thr Tyr Phe  Pro Thr Trp Glu Gly  Leu Phe Trp 
    1490                 1495                 1500             


Glu Lys  Ala Ser Gly Phe Glu  Glu Ser Met Lys Trp  Lys Lys Leu 
    1505                 1510                 1515             


Thr Asn  Ala Gln Arg Ser Gly  Leu Asn Gln Ile Pro  Asn Arg Arg 
    1520                 1525                 1530             


Phe Thr  Leu Trp Trp Ser Pro  Thr Ile Asn Arg Ala  Asn Val Tyr 
    1535                 1540                 1545             


Val Gly  Phe Gln Val Gln Leu  Asp Leu Thr Gly Ile  Phe Met His 
    1550                 1555                 1560             


Gly Lys  Ile Pro Thr Leu Lys  Ile Ser Leu Ile Gln  Ile Phe Arg 
    1565                 1570                 1575             


Ala His  Leu Trp Gln Lys Ile  His Glu Ser Ile Val  Met Asp Leu 
    1580                 1585                 1590             


Cys Gln  Val Phe Asp Gln Glu  Leu Asp Ala Leu Glu  Ile Glu Thr 
    1595                 1600                 1605             


Val Gln  Lys Glu Thr Ile His  Pro Arg Lys Ser Tyr  Lys Met Asn 
    1610                 1615                 1620             


Ser Ser  Cys Ala Asp Ile Leu  Leu Phe Ala Ser Tyr  Lys Trp Asn 
    1625                 1630                 1635             


Val Ser  Arg Pro Ser Leu Leu  Ala Asp Ser Lys Asp  Val Met Asp 
    1640                 1645                 1650             


Ser Thr  Thr Thr Gln Lys Tyr  Trp Ile Asp Ile Gln  Leu Arg Trp 
    1655                 1660                 1665             


Gly Asp  Tyr Asp Ser His Asp  Ile Glu Arg Tyr Ala  Arg Ala Lys 
    1670                 1675                 1680             


Phe Leu  Asp Tyr Thr Thr Asp  Asn Met Ser Ile Tyr  Pro Ser Pro 
    1685                 1690                 1695             


Thr Gly  Val Leu Ile Ala Ile  Asp Leu Ala Tyr Asn  Leu His Ser 
    1700                 1705                 1710             


Ala Tyr  Gly Asn Trp Phe Pro  Gly Ser Lys Pro Leu  Ile Gln Gln 
    1715                 1720                 1725             


Ala Met  Ala Lys Ile Met Lys  Ala Asn Pro Ala Leu  Tyr Val Leu 
    1730                 1735                 1740             


Arg Glu  Arg Ile Arg Lys Gly  Leu Gln Leu Tyr Ser  Ser Glu Pro 
    1745                 1750                 1755             


Thr Glu  Pro Tyr Leu Ser Ser  Gln Asn Tyr Gly Glu  Leu Phe Ser 
    1760                 1765                 1770             


Asn Gln  Ile Ile Trp Phe Val  Asp Asp Thr Asn Val  Tyr Arg Val 
    1775                 1780                 1785             


Thr Ile  His Lys Thr Phe Glu  Gly Asn Leu Thr Thr  Lys Pro Ile 
    1790                 1795                 1800             


Asn Gly  Ala Ile Phe Ile Phe  Asn Pro Arg Thr Gly  Gln Leu Phe 
    1805                 1810                 1815             


Leu Lys  Ile Ile His Thr Ser  Val Trp Ala Gly Gln  Lys Arg Leu 
    1820                 1825                 1830             


Gly Gln  Leu Ala Lys Trp Lys  Thr Ala Glu Glu Val  Ala Ala Leu 
    1835                 1840                 1845             


Ile Arg  Ser Leu Pro Val Glu  Glu Gln Pro Lys Gln  Ile Ile Val 
    1850                 1855                 1860             


Thr Arg  Lys Asp Met Leu Asp  Pro Leu Glu Val His  Leu Leu Asp 
    1865                 1870                 1875             


Phe Pro  Asn Ile Val Ile Lys  Gly Ser Glu Leu Gln  Leu Pro Phe 
    1880                 1885                 1890             


Gln Ala  Cys Leu Lys Val Glu  Lys Phe Gly Asp Leu  Ile Leu Lys 
    1895                 1900                 1905             


Ala Thr  Glu Pro Gln Met Val  Leu Phe Asn Leu Tyr  Asp Asp Trp 
    1910                 1915                 1920             


Leu Lys  Thr Ile Ser Ser Tyr  Thr Ala Phe Ser Arg  Leu Ile Leu 
    1925                 1930                 1935             


Ile Leu  Arg Ala Leu His Val  Asn Asn Asp Arg Ala  Lys Val Ile 
    1940                 1945                 1950             


Leu Lys  Pro Asp Lys Thr Thr  Ile Thr Glu Pro His  His Ile Trp 
    1955                 1960                 1965             


Pro Thr  Leu Thr Asp Glu Glu  Trp Ile Lys Val Glu  Val Gln Leu 
    1970                 1975                 1980             


Lys Asp  Leu Ile Leu Ala Asp  Tyr Gly Lys Lys Asn  Asn Val Asn 
    1985                 1990                 1995             


Val Ala  Ser Leu Thr Gln Ser  Glu Ile Arg Asp Ile  Ile Leu Gly 
    2000                 2005                 2010             


Met Glu  Ile Ser Ala Pro Ser  Gln Gln Arg Gln Gln  Ile Ala Glu 
    2015                 2020                 2025             


Ile Glu  Lys Gln Thr Lys Glu  Gln Ser Gln Leu Thr  Ala Thr Gln 
    2030                 2035                 2040             


Thr Arg  Thr Val Asn Lys His  Gly Asp Glu Ile Ile  Thr Ser Thr 
    2045                 2050                 2055             


Thr Ser  Asn Tyr Glu Thr Gln  Thr Phe Ser Ser Lys  Thr Glu Trp 
    2060                 2065                 2070             


Arg Val  Arg Ala Ile Ser Ala  Ala Asn Leu His Leu  Arg Thr Asn 
    2075                 2080                 2085             


His Ile  Tyr Val Ser Ser Asp  Asp Ile Lys Glu Thr  Gly Tyr Thr 
    2090                 2095                 2100             


Tyr Ile  Leu Pro Lys Asn Val  Leu Lys Lys Phe Ile  Cys Ile Ser 
    2105                 2110                 2115             


Asp Leu  Arg Ala Gln Ile Ala  Gly Tyr Leu Tyr Gly  Val Ser Pro 
    2120                 2125                 2130             


Pro Asp  Asn Pro Gln Val Lys  Glu Ile Arg Cys Ile  Val Met Val 
    2135                 2140                 2145             


Pro Gln  Trp Gly Thr His Gln  Thr Val His Leu Pro  Gly Gln Leu 
    2150                 2155                 2160             


Pro Gln  His Glu Tyr Leu Lys  Glu Met Glu Pro Leu  Gly Trp Ile 
    2165                 2170                 2175             


His Thr  Gln Pro Asn Glu Ser  Pro Gln Leu Ser Pro  Gln Asp Val 
    2180                 2185                 2190             


Thr Thr  His Ala Lys Ile Met  Ala Asp Asn Pro Ser  Trp Asp Gly 
    2195                 2200                 2205             


Glu Lys  Thr Ile Ile Ile Thr  Cys Ser Phe Thr Pro  Gly Ser Cys 
    2210                 2215                 2220             


Thr Leu  Thr Ala Tyr Lys Leu  Thr Pro Ser Gly Tyr  Glu Trp Gly 
    2225                 2230                 2235             


Arg Gln  Asn Thr Asp Lys Gly  Asn Asn Pro Lys Gly  Tyr Leu Pro 
    2240                 2245                 2250             


Ser His  Tyr Glu Arg Val Gln  Met Leu Leu Ser Asp  Arg Phe Leu 
    2255                 2260                 2265             


Gly Phe  Phe Met Val Pro Ala  Gln Ser Ser Trp Asn  Tyr Asn Phe 
    2270                 2275                 2280             


Met Gly  Val Arg His Asp Pro  Asn Met Lys Tyr Glu  Leu Gln Leu 
    2285                 2290                 2295             


Ala Asn  Pro Lys Glu Phe Tyr  His Glu Val His Arg  Pro Ser His 
    2300                 2305                 2310             


Phe Leu  Asn Phe Ala Leu Leu  Gln Glu Gly Glu Val  Tyr Ser Ala 
    2315                 2320                 2325             


Asp Arg  Glu Asp Leu Tyr Ala  
    2330                 2335 


<210>  40
<211>  7972
<212>  DNA
<213>  Homo sapiens

<400>  40
atttgaagtc ctcgttccac gccttctcat catcctgaac accgagctct gggactccgg       60

cggagaatct aaacgtaaag catcacccac ggtcgtgaac tgtaggctct cctggcatcc      120

gggatcttat tctggccttg gcggagttgg ggatggtgtc gcctagcagc cgctgccgct      180

ttggcttgct cgggaccatt tggctggacc cagagtccgc gtggaaccgc gatagggatc      240

tgtcagggcc cgcggccggg tccagcttgg tggttgcggt agtgagaggc ctccgctggt      300

tgccaggctt ggtctagagg tggagcacag tgaaagaatt caagatgcca cctaatataa      360

actggaaaga aataatgaaa gttgacccag atgacctgcc ccgtcaagaa gaactggcag      420

ataatttatt gatttcctta tccaaggtgg aagtaaatga gctaaaaagt gaaaagcaag      480

aaaatgtgat acaccttttc agaattactc agtcactaat gaagatgaaa gctcaagaag      540

tggagctggc tttggaagaa gtagaaaaag ctggagaaga acaagcaaaa tttgaaaatc      600

aattaaaaac taaagtaatg aaactggaaa atgaactgga gatggctcag cagtctgcag      660

gtggacgaga tactcggttt ttacgtaatg aaatttgcca acttgaaaaa caattagaac      720

aaaaagatag agaattggag gacatggaaa aggagttgga gaaagagaag aaagttaatg      780

agcaattggc tcttcgaaat gaggaggcag aaaatgaaaa cagcaaatta agaagagaga      840

acaaacgtct aaagaaaaag aatgaacaac tttgtcagga tattattgac taccagaaac      900

aaatagattc acagaaagaa acacttttat caagaagagg ggaagacagt gactaccgat      960

cacagttgtc taaaaaaaac tatgagctta tccaatatct tgatgaaatt cagactttaa     1020

cagaagctaa tgagaaaatt gaagttcaga atcaagaaat gagaaaaaat ttagaagagt     1080

ctgtacagga aatggagaag atgactgatg aatataatag aatgaaagct attgtgcatc     1140

agacagataa tgtaatagat cagttaaaaa aagaaaacga tcattatcaa cttcaagtgc     1200

aggagcttac agatcttctg aaatcaaaaa atgaagaaga tgatccaatt atggtagctg     1260

tcaatgcaaa agtagaagaa tggaagctaa ttttgtcttc taaagatgat gaaattattg     1320

agtatcagca aatgttacat aacctaaggg agaaacttaa gaatgctcag cttgatgctg     1380

ataaaagtaa tgttatggct ctacagcagg gtatacagga acgagacagt caaattaaga     1440

tgctcaccga acaagtagaa caatatacaa aagaaatgga aaagaatact tgtattattg     1500

aagatttgaa aaatgagctc caaagaaaca aaggtgcttc aaccctttct caacagactc     1560

atatgaaaat tcagtcaacg ttagacattt taaaagagaa aactaaagag gctgagagaa     1620

cagctgaact ggctgaggct gatgctaggg aaaaggataa agaattagtt gaggctctga     1680

agaggttaaa agattatgaa tcgggagtat atggtttaga agatgctgtc gttgaaataa     1740

agaattgtaa aaaccaaatt aaaataagag atcgagagat tgaaatatta acaaaggaaa     1800

tcaataaact tgaattgaag atcagtgatt tccttgatga aaatgaggca cttagagagc     1860

gtgtgggcct tgaaccaaag acaatgattg atttaactga atttagaaat agcaaacact     1920

taaaacagca gcagtacaga gctgaaaacc agattctttt gaaagagatt gaaagtctag     1980

aggaagaacg acttgatctg aaaaaaaaaa ttcgtcaaat ggctcaagaa agaggaaaaa     2040

gaagtgcaac ttcaggatta accactgagg acctgaacct aactgaaaac atttctcaag     2100

gagatagaat aagtgaaaga aaattggatt tattgagcct caaaaatatg agtgaagcac     2160

aatcaaagaa tgaatttctt tcaagagaac taattgaaaa agaaagagat ttagaaagga     2220

gtaggacagt gatagccaaa tttcagaata aattaaaaga attagttgaa gaaaataagc     2280

aacttgaaga aggtatgaaa gaaatattgc aagcaattaa ggaaatgcag aaagatcctg     2340

atgttaaagg aggagaaaca tctctaatta tccctagcct tgaaagacta gttaatgcta     2400

tagaatcaaa gaatgcagaa ggaatctttg atgcgagtct gcatttgaaa gcccaagttg     2460

atcagcttac cggaagaaat gaagaattaa gacaggagct cagggaatct cggaaagagg     2520

ctataaatta ttcacagcag ttggcaaaag ctaatttaaa gatagaccat cttgaaaaag     2580

aaactagtct tttacgacaa tcagaaggat cgaatgttgt ttttaaagga attgacttac     2640

ctgatgggat agcaccatct agtgccagta tcattaattc tcagaatgaa tatttaatac     2700

atttgttaca ggaactagaa aataaagaaa aaaagttaaa gaatttagaa gattctcttg     2760

aagattacaa cagaaaattt gctgtaattc gtcatcaaca aagtttgttg tataaagaat     2820

acctaagtga aaaggagacc tggaaaacag aatctaaaac aataaaagag gaaaagagaa     2880

aacttgagga tcaagtccaa caagatgcta taaaagtaaa agaatataat aatttgctca     2940

atgctcttca gatggattcg gatgaaatga aaaaaatact tgcagaaaat agtaggaaaa     3000

ttactgtttt gcaagtgaat gaaaaatcac ttataaggca atatacaacc ttagtagaat     3060

tggagcgaca acttagaaaa gaaaatgaga agcaaaagaa tgaattgttg tcaatggagg     3120

ctgaagtttg tgaaaaaatt gggtgtttgc aaagatttaa ggaaatggcc attttcaaga     3180

ttgcagctct ccaaaaagtt gtagataata gtgtttcttt gtctgaacta gaactggcta     3240

ataaacagta caatgaactg actgctaagt acagggacat cttgcaaaaa gataatatgc     3300

ttgttcaaag aacaagtaac ttggaacacc tggagtgtga aaacatctcc ttaaaagaac     3360

aagtggagtc tataaataaa gaactggaga ttaccaagga aaaacttcac actattgaac     3420

aagcctggga acaggaaact aaattaggta atgaatctag catggataag gcaaagaaat     3480

caataaccaa cagtgacatt gtttccattt caaaaaaaat aactatgctg gaaatgaagg     3540

aattaaatga aaggcagcgg gctgaacatt gtcaaaaaat gtatgaacac ttacggactt     3600

cgttaaagca aatggaggaa cgtaattttg aattggaaac caaatttgct gagcttacca     3660

aaatcaattt ggatgcacag aaggtggaac agatgttaag agatgaatta gctgatagtg     3720

tgagcaaggc agtaagtgat gctgataggc aacggattct agaattagag aagaatgaaa     3780

tggaactaaa agttgaagtg tcaaaactga gagagatttc tgatattgcc agaagacaag     3840

ttgaaatttt gaatgcacaa caacaatcta gggacaagga agtagagtcc ctcagaatgc     3900

aactgctaga ctatcaggca cagtctgatg aaaagtcgct cattgccaag ttgcaccaac     3960

ataatgtctc tcttcaactg agtgaggcta ctgctcttgg taagttggag tcaattacat     4020

ctaaactgca gaagatggag gcctacaact tgcgcttaga gcagaaactt gatgaaaaag     4080

aacaggctct ctattatgct cgtttggagg gaagaaacag agcaaaacat ctgcgccaaa     4140

caattcagtc tctacgacga cagtttagtg gagctttacc cttggcacaa caggaaaagt     4200

tctccaaaac aatgattcaa ctacaaaatg acaaacttaa gataatgcaa gaaatgaaaa     4260

attctcaaca agaacataga aatatggaga acaaaacatt ggagatggaa ttaaaattaa     4320

agggcctgga agagttaata agcactttaa aggataccaa aggagcccaa aaggtaatca     4380

actggcatat gaaaatagaa gaacttcgtc ttcaagaact taaactaaat cgggaattag     4440

tcaaggataa agaagaaata aaatatttga ataacataat ttctgaatat gaacgtacaa     4500

tcagcagtct tgaagaagaa attgtgcaac agaacaagtt tcatgaagaa agacaaatgg     4560

cctgggatca aagagaagtt gacctggaac gccaactaga catttttgac cgtcagcaaa     4620

atgaaatact aaatgcggca caaaagtttg aagaagctac aggatcaatc cctgacccta     4680

gtttgcccct tccaaatcaa cttgagatcg ctctaaggaa aattaaggag aacattcgaa     4740

taattctaga aacacgggca acttgcaaat cactagaaga gaaactaaaa gagaaagaat     4800

ctgctttaag gttagcagaa caaaatatac tgtcaagaga caaagtaatc aatgaactga     4860

ggcttcgatt gcctgccact gcagaaagag aaaagctcat agctgagcta ggcagaaaag     4920

agatggaacc aaaatctcac cacacattga aaattgctca tcaaaccatt gcaaacatgc     4980

aagcaaggtt aaatcaaaaa gaagaagtat taaagaagta tcaacgtctt ctagaaaaag     5040

ccagagagga gcaaagagaa attgtgaaga aacatgagga agaccttcat attcttcatc     5100

acagattaga actacaggct gatagttcac taaataaatt caaacaaacg gcttgggatt     5160

taatgaaaca gtctcccact ccagttccta ccaacaagca ttttattcgt ctggctgaga     5220

tggaacagac agtagcagaa caagatgact ctctttcctc actcttggtc aaactaaaga     5280

aagtatcaca agatttggag agacaaagag aaatcactga attaaaagta aaagaatttg     5340

aaaatatcaa attacagctt caagaaaacc atgaagatga agtgaaaaaa gtaaaagcgg     5400

aagtagagga tttaaagtat cttctggacc agtcacaaaa ggagtcacag tgtttaaaat     5460

ctgaacttca ggctcaaaaa gaagcaaatt caagagctcc aacaactaca atgagaaatc     5520

tagtagaacg gctaaagagc caattagcct tgaaggagaa acaacagaaa gcacttagtc     5580

gggcactttt agaactccgg gcagaaatga cagcagctgc tgaagaacgt attatttctg     5640

caacttctca aaaagaggcc catctcaatg ttcaacaaat cgttgatcga catactagag     5700

agctaaagac acaagttgaa gatttaaatg aaaatctttt aaaattgaaa gaagcactta     5760

aaacaagtaa aaacagagaa aactcactaa ctgataattt gaatgactta aataatgaac     5820

tgcaaaagaa acaaaaagcc tataataaaa tacttagaga gaaagaggaa attgatcaag     5880

agaatgatga actgaaaagg caaattaaaa gactaaccag tggattacag ggcaaacccc     5940

tgacagataa taaacaaagt ctaattgaag aactccaaag gaaagttaaa aaactagaga     6000

accaattaga gggaaaggtg gaggaagtag acctaaaacc tatgaaagaa aagaatgcta     6060

aagaagaatt aattaggtgg gaagaaggta aaaagtggca agccaaaata gaaggaattc     6120

gaaacaagtt aaaagagaaa gagggggaag tctttacttt aacaaagcag ttgaatactt     6180

tgaaggatct ttttgccaaa gccgataaag agaaacttac tttgcagagg aaactaaaaa     6240

caactggcat gactgttgat caggttttgg gaatacgagc tttggagtca gaaaaagaat     6300

tggaagaatt aaaaaagaga aatcttgact tagaaaatga tatattgtat atgagggccc     6360

accaagctct tcctcgagat tctgttgtag aagatttaca tttacaaaat agatacctcc     6420

aagaaaaact tcatgcttta gaaaaacagt tttcaaagga tacatattct aagccttcaa     6480

tttcaggaat agagtcagat gatcattgtc agagagaaca ggagcttcag aaggaaaact     6540

tgaagttgtc atctgaaaat attgaactga aatttcagct tgaacaagca aataaagatt     6600

tgccaagatt aaagaatcaa gtcagagatt tgaaggaaat gtgtgaattt cttaagaaag     6660

aaaaagcaga agttcagcgg aaacttggcc atgttagagg gtctggtaga agtggaaaga     6720

caatcccaga actggaaaaa accattggtt taatgaaaaa agtagttgaa aaagtccaga     6780

gagaaaatga acagttgaaa aaagcatcag gaatattgac tagtgaaaaa atggctaata     6840

ttgagcagga aaatgaaaaa ttgaaggctg aattagaaaa acttaaagct catcttgggc     6900

atcagttgag catgcactat gaatccaaga ccaaaggcac agaaaaaatt attgctgaaa     6960

atgaaaggct tcgtaaagaa cttaaaaaag aaactgatgc tgcagagaaa ttacggatag     7020

caaagaataa tttagagata ttaaatgaga agatgacagt tcaactagaa gagactggta     7080

agagattgca gtttgcagaa agcagaggtc cacagcttga aggtgctgac agtaagagct     7140

ggaaatccat tgtggttaca agaatgtatg aaaccaagtt aaaagaattg gaaactgata     7200

ttgccaaaaa aaatcaaagc attactgacc ttaaacagct tgtaaaagaa gcaacagaga     7260

gagaacaaaa agttaacaaa tacaatgaag accttgaaca acagattaag attcttaaac     7320

atgttcctga aggtgctgag acagagcaag gccttaaacg ggagcttcaa gttcttagat     7380

tagctaatca tcagctggat aaagagaaag cagaattaat ccatcagata gaagctaaca     7440

aggaccaaag tggagctgaa agcaccatac ctgatgctga tcaactaaag gaaaaaataa     7500

aagatctaga gacacagctc aaaatgtcag atctagaaaa gcagcatttg aaggaggaaa     7560

taaagaagct gaaaaaagaa ctggaaaatt ttgatccttc attttttgaa gaaattgaag     7620

atcttaagta taattacaag gaagaagtga agaagaatat tctcttagaa gagaaggtaa     7680

aaaaactttc agaacaattg ggagttgaat taactagccc tgttgctgct tctgaagagt     7740

ttgaagatga agaagaaagt cctgttaatt tccccattta ctaaaggtca cctataaact     7800

ttgtttcatt taactattta ttaactttat aagttaaata tacttggaaa taagcagttc     7860

tccgaactgt agtatttcct tctcactacc ttgtaccttt atacttagat tggaattctt     7920

aataaataaa attatatgaa attttcaact tattaaaaaa aaaaaaaaaa aa             7972


<210>  41
<211>  2479
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Pro Pro Asn Ile Asn Trp Lys Glu Ile Met Lys Val Asp Pro Asp 
1               5                   10                  15      


Asp Leu Pro Arg Gln Glu Glu Leu Ala Asp Asn Leu Leu Ile Ser Leu 
            20                  25                  30          


Ser Lys Val Glu Val Asn Glu Leu Lys Ser Glu Lys Gln Glu Asn Val 
        35                  40                  45              


Ile His Leu Phe Arg Ile Thr Gln Ser Leu Met Lys Met Lys Ala Gln 
    50                  55                  60                  


Glu Val Glu Leu Ala Leu Glu Glu Val Glu Lys Ala Gly Glu Glu Gln 
65                  70                  75                  80  


Ala Lys Phe Glu Asn Gln Leu Lys Thr Lys Val Met Lys Leu Glu Asn 
                85                  90                  95      


Glu Leu Glu Met Ala Gln Gln Ser Ala Gly Gly Arg Asp Thr Arg Phe 
            100                 105                 110         


Leu Arg Asn Glu Ile Cys Gln Leu Glu Lys Gln Leu Glu Gln Lys Asp 
        115                 120                 125             


Arg Glu Leu Glu Asp Met Glu Lys Glu Leu Glu Lys Glu Lys Lys Val 
    130                 135                 140                 


Asn Glu Gln Leu Ala Leu Arg Asn Glu Glu Ala Glu Asn Glu Asn Ser 
145                 150                 155                 160 


Lys Leu Arg Arg Glu Asn Lys Arg Leu Lys Lys Lys Asn Glu Gln Leu 
                165                 170                 175     


Cys Gln Asp Ile Ile Asp Tyr Gln Lys Gln Ile Asp Ser Gln Lys Glu 
            180                 185                 190         


Thr Leu Leu Ser Arg Arg Gly Glu Asp Ser Asp Tyr Arg Ser Gln Leu 
        195                 200                 205             


Ser Lys Lys Asn Tyr Glu Leu Ile Gln Tyr Leu Asp Glu Ile Gln Thr 
    210                 215                 220                 


Leu Thr Glu Ala Asn Glu Lys Ile Glu Val Gln Asn Gln Glu Met Arg 
225                 230                 235                 240 


Lys Asn Leu Glu Glu Ser Val Gln Glu Met Glu Lys Met Thr Asp Glu 
                245                 250                 255     


Tyr Asn Arg Met Lys Ala Ile Val His Gln Thr Asp Asn Val Ile Asp 
            260                 265                 270         


Gln Leu Lys Lys Glu Asn Asp His Tyr Gln Leu Gln Val Gln Glu Leu 
        275                 280                 285             


Thr Asp Leu Leu Lys Ser Lys Asn Glu Glu Asp Asp Pro Ile Met Val 
    290                 295                 300                 


Ala Val Asn Ala Lys Val Glu Glu Trp Lys Leu Ile Leu Ser Ser Lys 
305                 310                 315                 320 


Asp Asp Glu Ile Ile Glu Tyr Gln Gln Met Leu His Asn Leu Arg Glu 
                325                 330                 335     


Lys Leu Lys Asn Ala Gln Leu Asp Ala Asp Lys Ser Asn Val Met Ala 
            340                 345                 350         


Leu Gln Gln Gly Ile Gln Glu Arg Asp Ser Gln Ile Lys Met Leu Thr 
        355                 360                 365             


Glu Gln Val Glu Gln Tyr Thr Lys Glu Met Glu Lys Asn Thr Cys Ile 
    370                 375                 380                 


Ile Glu Asp Leu Lys Asn Glu Leu Gln Arg Asn Lys Gly Ala Ser Thr 
385                 390                 395                 400 


Leu Ser Gln Gln Thr His Met Lys Ile Gln Ser Thr Leu Asp Ile Leu 
                405                 410                 415     


Lys Glu Lys Thr Lys Glu Ala Glu Arg Thr Ala Glu Leu Ala Glu Ala 
            420                 425                 430         


Asp Ala Arg Glu Lys Asp Lys Glu Leu Val Glu Ala Leu Lys Arg Leu 
        435                 440                 445             


Lys Asp Tyr Glu Ser Gly Val Tyr Gly Leu Glu Asp Ala Val Val Glu 
    450                 455                 460                 


Ile Lys Asn Cys Lys Asn Gln Ile Lys Ile Arg Asp Arg Glu Ile Glu 
465                 470                 475                 480 


Ile Leu Thr Lys Glu Ile Asn Lys Leu Glu Leu Lys Ile Ser Asp Phe 
                485                 490                 495     


Leu Asp Glu Asn Glu Ala Leu Arg Glu Arg Val Gly Leu Glu Pro Lys 
            500                 505                 510         


Thr Met Ile Asp Leu Thr Glu Phe Arg Asn Ser Lys His Leu Lys Gln 
        515                 520                 525             


Gln Gln Tyr Arg Ala Glu Asn Gln Ile Leu Leu Lys Glu Ile Glu Ser 
    530                 535                 540                 


Leu Glu Glu Glu Arg Leu Asp Leu Lys Lys Lys Ile Arg Gln Met Ala 
545                 550                 555                 560 


Gln Glu Arg Gly Lys Arg Ser Ala Thr Ser Gly Leu Thr Thr Glu Asp 
                565                 570                 575     


Leu Asn Leu Thr Glu Asn Ile Ser Gln Gly Asp Arg Ile Ser Glu Arg 
            580                 585                 590         


Lys Leu Asp Leu Leu Ser Leu Lys Asn Met Ser Glu Ala Gln Ser Lys 
        595                 600                 605             


Asn Glu Phe Leu Ser Arg Glu Leu Ile Glu Lys Glu Arg Asp Leu Glu 
    610                 615                 620                 


Arg Ser Arg Thr Val Ile Ala Lys Phe Gln Asn Lys Leu Lys Glu Leu 
625                 630                 635                 640 


Val Glu Glu Asn Lys Gln Leu Glu Glu Gly Met Lys Glu Ile Leu Gln 
                645                 650                 655     


Ala Ile Lys Glu Met Gln Lys Asp Pro Asp Val Lys Gly Gly Glu Thr 
            660                 665                 670         


Ser Leu Ile Ile Pro Ser Leu Glu Arg Leu Val Asn Ala Ile Glu Ser 
        675                 680                 685             


Lys Asn Ala Glu Gly Ile Phe Asp Ala Ser Leu His Leu Lys Ala Gln 
    690                 695                 700                 


Val Asp Gln Leu Thr Gly Arg Asn Glu Glu Leu Arg Gln Glu Leu Arg 
705                 710                 715                 720 


Glu Ser Arg Lys Glu Ala Ile Asn Tyr Ser Gln Gln Leu Ala Lys Ala 
                725                 730                 735     


Asn Leu Lys Ile Asp His Leu Glu Lys Glu Thr Ser Leu Leu Arg Gln 
            740                 745                 750         


Ser Glu Gly Ser Asn Val Val Phe Lys Gly Ile Asp Leu Pro Asp Gly 
        755                 760                 765             


Ile Ala Pro Ser Ser Ala Ser Ile Ile Asn Ser Gln Asn Glu Tyr Leu 
    770                 775                 780                 


Ile His Leu Leu Gln Glu Leu Glu Asn Lys Glu Lys Lys Leu Lys Asn 
785                 790                 795                 800 


Leu Glu Asp Ser Leu Glu Asp Tyr Asn Arg Lys Phe Ala Val Ile Arg 
                805                 810                 815     


His Gln Gln Ser Leu Leu Tyr Lys Glu Tyr Leu Ser Glu Lys Glu Thr 
            820                 825                 830         


Trp Lys Thr Glu Ser Lys Thr Ile Lys Glu Glu Lys Arg Lys Leu Glu 
        835                 840                 845             


Asp Gln Val Gln Gln Asp Ala Ile Lys Val Lys Glu Tyr Asn Asn Leu 
    850                 855                 860                 


Leu Asn Ala Leu Gln Met Asp Ser Asp Glu Met Lys Lys Ile Leu Ala 
865                 870                 875                 880 


Glu Asn Ser Arg Lys Ile Thr Val Leu Gln Val Asn Glu Lys Ser Leu 
                885                 890                 895     


Ile Arg Gln Tyr Thr Thr Leu Val Glu Leu Glu Arg Gln Leu Arg Lys 
            900                 905                 910         


Glu Asn Glu Lys Gln Lys Asn Glu Leu Leu Ser Met Glu Ala Glu Val 
        915                 920                 925             


Cys Glu Lys Ile Gly Cys Leu Gln Arg Phe Lys Glu Met Ala Ile Phe 
    930                 935                 940                 


Lys Ile Ala Ala Leu Gln Lys Val Val Asp Asn Ser Val Ser Leu Ser 
945                 950                 955                 960 


Glu Leu Glu Leu Ala Asn Lys Gln Tyr Asn Glu Leu Thr Ala Lys Tyr 
                965                 970                 975     


Arg Asp Ile Leu Gln Lys Asp Asn Met Leu Val Gln Arg Thr Ser Asn 
            980                 985                 990         


Leu Glu His Leu Glu Cys Glu Asn  Ile Ser Leu Lys Glu  Gln Val Glu 
        995                 1000                 1005             


Ser Ile  Asn Lys Glu Leu Glu  Ile Thr Lys Glu Lys  Leu His Thr 
    1010                 1015                 1020             


Ile Glu  Gln Ala Trp Glu Gln  Glu Thr Lys Leu Gly  Asn Glu Ser 
    1025                 1030                 1035             


Ser Met  Asp Lys Ala Lys Lys  Ser Ile Thr Asn Ser  Asp Ile Val 
    1040                 1045                 1050             


Ser Ile  Ser Lys Lys Ile Thr  Met Leu Glu Met Lys  Glu Leu Asn 
    1055                 1060                 1065             


Glu Arg  Gln Arg Ala Glu His  Cys Gln Lys Met Tyr  Glu His Leu 
    1070                 1075                 1080             


Arg Thr  Ser Leu Lys Gln Met  Glu Glu Arg Asn Phe  Glu Leu Glu 
    1085                 1090                 1095             


Thr Lys  Phe Ala Glu Leu Thr  Lys Ile Asn Leu Asp  Ala Gln Lys 
    1100                 1105                 1110             


Val Glu  Gln Met Leu Arg Asp  Glu Leu Ala Asp Ser  Val Ser Lys 
    1115                 1120                 1125             


Ala Val  Ser Asp Ala Asp Arg  Gln Arg Ile Leu Glu  Leu Glu Lys 
    1130                 1135                 1140             


Asn Glu  Met Glu Leu Lys Val  Glu Val Ser Lys Leu  Arg Glu Ile 
    1145                 1150                 1155             


Ser Asp  Ile Ala Arg Arg Gln  Val Glu Ile Leu Asn  Ala Gln Gln 
    1160                 1165                 1170             


Gln Ser  Arg Asp Lys Glu Val  Glu Ser Leu Arg Met  Gln Leu Leu 
    1175                 1180                 1185             


Asp Tyr  Gln Ala Gln Ser Asp  Glu Lys Ser Leu Ile  Ala Lys Leu 
    1190                 1195                 1200             


His Gln  His Asn Val Ser Leu  Gln Leu Ser Glu Ala  Thr Ala Leu 
    1205                 1210                 1215             


Gly Lys  Leu Glu Ser Ile Thr  Ser Lys Leu Gln Lys  Met Glu Ala 
    1220                 1225                 1230             


Tyr Asn  Leu Arg Leu Glu Gln  Lys Leu Asp Glu Lys  Glu Gln Ala 
    1235                 1240                 1245             


Leu Tyr  Tyr Ala Arg Leu Glu  Gly Arg Asn Arg Ala  Lys His Leu 
    1250                 1255                 1260             


Arg Gln  Thr Ile Gln Ser Leu  Arg Arg Gln Phe Ser  Gly Ala Leu 
    1265                 1270                 1275             


Pro Leu  Ala Gln Gln Glu Lys  Phe Ser Lys Thr Met  Ile Gln Leu 
    1280                 1285                 1290             


Gln Asn  Asp Lys Leu Lys Ile  Met Gln Glu Met Lys  Asn Ser Gln 
    1295                 1300                 1305             


Gln Glu  His Arg Asn Met Glu  Asn Lys Thr Leu Glu  Met Glu Leu 
    1310                 1315                 1320             


Lys Leu  Lys Gly Leu Glu Glu  Leu Ile Ser Thr Leu  Lys Asp Thr 
    1325                 1330                 1335             


Lys Gly  Ala Gln Lys Val Ile  Asn Trp His Met Lys  Ile Glu Glu 
    1340                 1345                 1350             


Leu Arg  Leu Gln Glu Leu Lys  Leu Asn Arg Glu Leu  Val Lys Asp 
    1355                 1360                 1365             


Lys Glu  Glu Ile Lys Tyr Leu  Asn Asn Ile Ile Ser  Glu Tyr Glu 
    1370                 1375                 1380             


Arg Thr  Ile Ser Ser Leu Glu  Glu Glu Ile Val Gln  Gln Asn Lys 
    1385                 1390                 1395             


Phe His  Glu Glu Arg Gln Met  Ala Trp Asp Gln Arg  Glu Val Asp 
    1400                 1405                 1410             


Leu Glu  Arg Gln Leu Asp Ile  Phe Asp Arg Gln Gln  Asn Glu Ile 
    1415                 1420                 1425             


Leu Asn  Ala Ala Gln Lys Phe  Glu Glu Ala Thr Gly  Ser Ile Pro 
    1430                 1435                 1440             


Asp Pro  Ser Leu Pro Leu Pro  Asn Gln Leu Glu Ile  Ala Leu Arg 
    1445                 1450                 1455             


Lys Ile  Lys Glu Asn Ile Arg  Ile Ile Leu Glu Thr  Arg Ala Thr 
    1460                 1465                 1470             


Cys Lys  Ser Leu Glu Glu Lys  Leu Lys Glu Lys Glu  Ser Ala Leu 
    1475                 1480                 1485             


Arg Leu  Ala Glu Gln Asn Ile  Leu Ser Arg Asp Lys  Val Ile Asn 
    1490                 1495                 1500             


Glu Leu  Arg Leu Arg Leu Pro  Ala Thr Ala Glu Arg  Glu Lys Leu 
    1505                 1510                 1515             


Ile Ala  Glu Leu Gly Arg Lys  Glu Met Glu Pro Lys  Ser His His 
    1520                 1525                 1530             


Thr Leu  Lys Ile Ala His Gln  Thr Ile Ala Asn Met  Gln Ala Arg 
    1535                 1540                 1545             


Leu Asn  Gln Lys Glu Glu Val  Leu Lys Lys Tyr Gln  Arg Leu Leu 
    1550                 1555                 1560             


Glu Lys  Ala Arg Glu Glu Gln  Arg Glu Ile Val Lys  Lys His Glu 
    1565                 1570                 1575             


Glu Asp  Leu His Ile Leu His  His Arg Leu Glu Leu  Gln Ala Asp 
    1580                 1585                 1590             


Ser Ser  Leu Asn Lys Phe Lys  Gln Thr Ala Trp Asp  Leu Met Lys 
    1595                 1600                 1605             


Gln Ser  Pro Thr Pro Val Pro  Thr Asn Lys His Phe  Ile Arg Leu 
    1610                 1615                 1620             


Ala Glu  Met Glu Gln Thr Val  Ala Glu Gln Asp Asp  Ser Leu Ser 
    1625                 1630                 1635             


Ser Leu  Leu Val Lys Leu Lys  Lys Val Ser Gln Asp  Leu Glu Arg 
    1640                 1645                 1650             


Gln Arg  Glu Ile Thr Glu Leu  Lys Val Lys Glu Phe  Glu Asn Ile 
    1655                 1660                 1665             


Lys Leu  Gln Leu Gln Glu Asn  His Glu Asp Glu Val  Lys Lys Val 
    1670                 1675                 1680             


Lys Ala  Glu Val Glu Asp Leu  Lys Tyr Leu Leu Asp  Gln Ser Gln 
    1685                 1690                 1695             


Lys Glu  Ser Gln Cys Leu Lys  Ser Glu Leu Gln Ala  Gln Lys Glu 
    1700                 1705                 1710             


Ala Asn  Ser Arg Ala Pro Thr  Thr Thr Met Arg Asn  Leu Val Glu 
    1715                 1720                 1725             


Arg Leu  Lys Ser Gln Leu Ala  Leu Lys Glu Lys Gln  Gln Lys Ala 
    1730                 1735                 1740             


Leu Ser  Arg Ala Leu Leu Glu  Leu Arg Ala Glu Met  Thr Ala Ala 
    1745                 1750                 1755             


Ala Glu  Glu Arg Ile Ile Ser  Ala Thr Ser Gln Lys  Glu Ala His 
    1760                 1765                 1770             


Leu Asn  Val Gln Gln Ile Val  Asp Arg His Thr Arg  Glu Leu Lys 
    1775                 1780                 1785             


Thr Gln  Val Glu Asp Leu Asn  Glu Asn Leu Leu Lys  Leu Lys Glu 
    1790                 1795                 1800             


Ala Leu  Lys Thr Ser Lys Asn  Arg Glu Asn Ser Leu  Thr Asp Asn 
    1805                 1810                 1815             


Leu Asn  Asp Leu Asn Asn Glu  Leu Gln Lys Lys Gln  Lys Ala Tyr 
    1820                 1825                 1830             


Asn Lys  Ile Leu Arg Glu Lys  Glu Glu Ile Asp Gln  Glu Asn Asp 
    1835                 1840                 1845             


Glu Leu  Lys Arg Gln Ile Lys  Arg Leu Thr Ser Gly  Leu Gln Gly 
    1850                 1855                 1860             


Lys Pro  Leu Thr Asp Asn Lys  Gln Ser Leu Ile Glu  Glu Leu Gln 
    1865                 1870                 1875             


Arg Lys  Val Lys Lys Leu Glu  Asn Gln Leu Glu Gly  Lys Val Glu 
    1880                 1885                 1890             


Glu Val  Asp Leu Lys Pro Met  Lys Glu Lys Asn Ala  Lys Glu Glu 
    1895                 1900                 1905             


Leu Ile  Arg Trp Glu Glu Gly  Lys Lys Trp Gln Ala  Lys Ile Glu 
    1910                 1915                 1920             


Gly Ile  Arg Asn Lys Leu Lys  Glu Lys Glu Gly Glu  Val Phe Thr 
    1925                 1930                 1935             


Leu Thr  Lys Gln Leu Asn Thr  Leu Lys Asp Leu Phe  Ala Lys Ala 
    1940                 1945                 1950             


Asp Lys  Glu Lys Leu Thr Leu  Gln Arg Lys Leu Lys  Thr Thr Gly 
    1955                 1960                 1965             


Met Thr  Val Asp Gln Val Leu  Gly Ile Arg Ala Leu  Glu Ser Glu 
    1970                 1975                 1980             


Lys Glu  Leu Glu Glu Leu Lys  Lys Arg Asn Leu Asp  Leu Glu Asn 
    1985                 1990                 1995             


Asp Ile  Leu Tyr Met Arg Ala  His Gln Ala Leu Pro  Arg Asp Ser 
    2000                 2005                 2010             


Val Val  Glu Asp Leu His Leu  Gln Asn Arg Tyr Leu  Gln Glu Lys 
    2015                 2020                 2025             


Leu His  Ala Leu Glu Lys Gln  Phe Ser Lys Asp Thr  Tyr Ser Lys 
    2030                 2035                 2040             


Pro Ser  Ile Ser Gly Ile Glu  Ser Asp Asp His Cys  Gln Arg Glu 
    2045                 2050                 2055             


Gln Glu  Leu Gln Lys Glu Asn  Leu Lys Leu Ser Ser  Glu Asn Ile 
    2060                 2065                 2070             


Glu Leu  Lys Phe Gln Leu Glu  Gln Ala Asn Lys Asp  Leu Pro Arg 
    2075                 2080                 2085             


Leu Lys  Asn Gln Val Arg Asp  Leu Lys Glu Met Cys  Glu Phe Leu 
    2090                 2095                 2100             


Lys Lys  Glu Lys Ala Glu Val  Gln Arg Lys Leu Gly  His Val Arg 
    2105                 2110                 2115             


Gly Ser  Gly Arg Ser Gly Lys  Thr Ile Pro Glu Leu  Glu Lys Thr 
    2120                 2125                 2130             


Ile Gly  Leu Met Lys Lys Val  Val Glu Lys Val Gln  Arg Glu Asn 
    2135                 2140                 2145             


Glu Gln  Leu Lys Lys Ala Ser  Gly Ile Leu Thr Ser  Glu Lys Met 
    2150                 2155                 2160             


Ala Asn  Ile Glu Gln Glu Asn  Glu Lys Leu Lys Ala  Glu Leu Glu 
    2165                 2170                 2175             


Lys Leu  Lys Ala His Leu Gly  His Gln Leu Ser Met  His Tyr Glu 
    2180                 2185                 2190             


Ser Lys  Thr Lys Gly Thr Glu  Lys Ile Ile Ala Glu  Asn Glu Arg 
    2195                 2200                 2205             


Leu Arg  Lys Glu Leu Lys Lys  Glu Thr Asp Ala Ala  Glu Lys Leu 
    2210                 2215                 2220             


Arg Ile  Ala Lys Asn Asn Leu  Glu Ile Leu Asn Glu  Lys Met Thr 
    2225                 2230                 2235             


Val Gln  Leu Glu Glu Thr Gly  Lys Arg Leu Gln Phe  Ala Glu Ser 
    2240                 2245                 2250             


Arg Gly  Pro Gln Leu Glu Gly  Ala Asp Ser Lys Ser  Trp Lys Ser 
    2255                 2260                 2265             


Ile Val  Val Thr Arg Met Tyr  Glu Thr Lys Leu Lys  Glu Leu Glu 
    2270                 2275                 2280             


Thr Asp  Ile Ala Lys Lys Asn  Gln Ser Ile Thr Asp  Leu Lys Gln 
    2285                 2290                 2295             


Leu Val  Lys Glu Ala Thr Glu  Arg Glu Gln Lys Val  Asn Lys Tyr 
    2300                 2305                 2310             


Asn Glu  Asp Leu Glu Gln Gln  Ile Lys Ile Leu Lys  His Val Pro 
    2315                 2320                 2325             


Glu Gly  Ala Glu Thr Glu Gln  Gly Leu Lys Arg Glu  Leu Gln Val 
    2330                 2335                 2340             


Leu Arg  Leu Ala Asn His Gln  Leu Asp Lys Glu Lys  Ala Glu Leu 
    2345                 2350                 2355             


Ile His  Gln Ile Glu Ala Asn  Lys Asp Gln Ser Gly  Ala Glu Ser 
    2360                 2365                 2370             


Thr Ile  Pro Asp Ala Asp Gln  Leu Lys Glu Lys Ile  Lys Asp Leu 
    2375                 2380                 2385             


Glu Thr  Gln Leu Lys Met Ser  Asp Leu Glu Lys Gln  His Leu Lys 
    2390                 2395                 2400             


Glu Glu  Ile Lys Lys Leu Lys  Lys Glu Leu Glu Asn  Phe Asp Pro 
    2405                 2410                 2415             


Ser Phe  Phe Glu Glu Ile Glu  Asp Leu Lys Tyr Asn  Tyr Lys Glu 
    2420                 2425                 2430             


Glu Val  Lys Lys Asn Ile Leu  Leu Glu Glu Lys Val  Lys Lys Leu 
    2435                 2440                 2445             


Ser Glu  Gln Leu Gly Val Glu  Leu Thr Ser Pro Val  Ala Ala Ser 
    2450                 2455                 2460             


Glu Glu  Phe Glu Asp Glu Glu  Glu Ser Pro Val Asn  Phe Pro Ile 
    2465                 2470                 2475             


Tyr 
    


<210>  42
<211>  2625
<212>  DNA
<213>  Homo sapiens

<400>  42
actcgaccgg gctgcgctca ctgcccagcc ggggccccgg gagcctccag gctcccgccc       60

gccctgagct gcggcctccg catggagggg ccactcactc caccaccgct gcagggaggc      120

ggagccgccg ctgttccgga gcccggagcc cggcaacacc cgggacacga gacggcggcg      180

cagcggtaca gcgcccgact gctgcaggcc ggctacgagc ccgagagccc tagattggac      240

ctcgctacac acccgacgac accccgttca gaactatctt cagtggtctt actggcaggt      300

gttggtgtcc agatggatcg ccttcgcagg gctagcatgg cggactacct gatcagcggc      360

ggcaccggct acgtgcccga ggatgggctc accgcgcagc agctcttcgc cagcgccgac      420

ggcctcacct acaacgactt cctgattctc ccaggattca tagacttcat agctgatgag      480

gtggacctga cctcagccct gacccggaag atcacgctga agacgccact gatctcctcc      540

cccatggaca ctgtgacaga ggctgacatg gccattgcca tggctctgat gggaggtatt      600

ggtttcattc accacaactg caccccagag ttccaggcca acgaggtgcg gaaggtcaag      660

aagtttgaac agggcttcat cacggaccct gtggtgctga gcccctcgca cactgtgggc      720

gatgtgctgg aggccaagat gcggcatggc ttctctggca tccccatcac tgagacgggc      780

accatgggca gcaagctggt gggcatcgtc acctcccgag acatcgactt tcttgctgag      840

aaggaccaca ccaccctcct cagtgaggtg atgacgccaa ggattgaact ggtggtggct      900

ccagcaggtg tgacgttgaa agaggcaaat gagatcctgc agcgtagcaa gaaagggaag      960

ctgcctatcg tcaatgattg cgatgagctg gtggccatca tcgcccgcac cgacctgaag     1020

aagaaccgag actaccctct ggcctccaag gattcccaga agcagctgct ctgtggggca     1080

gctgtgggca cccgtgagga tgacaaatac cgtctggacc tgctcaccca ggcgggcgtc     1140

gacgtcatag tcttggactc gtcccaaggg aattcggtgt atcagatcgc catggtgcat     1200

tacatcaaac agaagtaccc ccacctccag gtgattgggg ggaacgtggt gacagcagcc     1260

caggccaaga acctgattga tgctggtgtg gacgggctgc gcgtgggcat gggctgcggc     1320

tccatctgca tcacccagga agtgatggcc tgtggtcggc cccagggcac tgctgtgtac     1380

aaggtggctg agtatgcccg gcgctttggt gtgcccatca tagccgatgg cggcatccag     1440

accgtgggac acgtggtcaa ggccctggcc cttggagcct ccacagtgat gatgggctcc     1500

ctgctggccg ccactacgga ggcccctggc gagtacttct tctcagacgg ggtgcggctc     1560

aagaagtacc ggggcatggg ctcactggat gccatggaga agagcagcag cagccagaaa     1620

cgatacttca gcgaggggga taaagtgaag atcgcgcagg gtgtctcggg ctccatccag     1680

gacaaaggat ccattcagaa gttcgtgccc tacctcatag caggcatcca acacggctgc     1740

caggatatcg gggcccgcag cctgtctgtc cttcggtcca tgatgtactc aggagagctc     1800

aagtttgaga agcggaccat gtcggcccag attgagggtg gtgtccatgg cctgcactct     1860

tacgaaaagc ggctgtactg aggacagcgg tggaggccga ggtggtggag gggatgcacc     1920

ccagtgtcca cttttgggca cagcctccct ccataactga gtggtccaca gatttgcact     1980

acgggttctc cagctccttt ccaggcagag aggaggggag gtcctgaggg gactgctgcc     2040

cctcactcgg catcccctgc agagtcagga ctgctcccgg ggccaggctg ccctgggagc     2100

ccccctccga gcccagccag ccaggctctc aggccctgcg cctgcctcag gtctttcttg     2160

ctgcagcctg ctccagcctg gcccccaccc caggggcagg cggcccctcc tggcttctcc     2220

tgtagggcac ctccctgccc ctagcctccc aggaaatggt gctctcctgg ccctgcctct     2280

ggcccttccc gggccgctgc ccctcagcca tgtggcactt ctgagctcct gacctaggcc     2340

aaggggaggt ctctgccccc ttccccggcc ctgggctacc cttgggtcct gctcctcagg     2400

ccgctcccct gtccctggcc atgggtagga gactgccctg gtcatggccg cctgcctgtc     2460

attcctgact caccaccgtc cccaggtgaa ccattcctcc cttctcctca gctgcagtcg     2520

aaggctttaa ctttgcacac ttgggatcac agttgcgtca ttgtgtatta aatacttgga     2580

ataaatcaag caggtctcaa cgcctccact aaaaaaaaaa aaaaa                     2625


<210>  43
<211>  599
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Glu Gly Pro Leu Thr Pro Pro Pro Leu Gln Gly Gly Gly Ala Ala 
1               5                   10                  15      


Ala Val Pro Glu Pro Gly Ala Arg Gln His Pro Gly His Glu Thr Ala 
            20                  25                  30          


Ala Gln Arg Tyr Ser Ala Arg Leu Leu Gln Ala Gly Tyr Glu Pro Glu 
        35                  40                  45              


Ser Pro Arg Leu Asp Leu Ala Thr His Pro Thr Thr Pro Arg Ser Glu 
    50                  55                  60                  


Leu Ser Ser Val Val Leu Leu Ala Gly Val Gly Val Gln Met Asp Arg 
65                  70                  75                  80  


Leu Arg Arg Ala Ser Met Ala Asp Tyr Leu Ile Ser Gly Gly Thr Gly 
                85                  90                  95      


Tyr Val Pro Glu Asp Gly Leu Thr Ala Gln Gln Leu Phe Ala Ser Ala 
            100                 105                 110         


Asp Gly Leu Thr Tyr Asn Asp Phe Leu Ile Leu Pro Gly Phe Ile Asp 
        115                 120                 125             


Phe Ile Ala Asp Glu Val Asp Leu Thr Ser Ala Leu Thr Arg Lys Ile 
    130                 135                 140                 


Thr Leu Lys Thr Pro Leu Ile Ser Ser Pro Met Asp Thr Val Thr Glu 
145                 150                 155                 160 


Ala Asp Met Ala Ile Ala Met Ala Leu Met Gly Gly Ile Gly Phe Ile 
                165                 170                 175     


His His Asn Cys Thr Pro Glu Phe Gln Ala Asn Glu Val Arg Lys Val 
            180                 185                 190         


Lys Lys Phe Glu Gln Gly Phe Ile Thr Asp Pro Val Val Leu Ser Pro 
        195                 200                 205             


Ser His Thr Val Gly Asp Val Leu Glu Ala Lys Met Arg His Gly Phe 
    210                 215                 220                 


Ser Gly Ile Pro Ile Thr Glu Thr Gly Thr Met Gly Ser Lys Leu Val 
225                 230                 235                 240 


Gly Ile Val Thr Ser Arg Asp Ile Asp Phe Leu Ala Glu Lys Asp His 
                245                 250                 255     


Thr Thr Leu Leu Ser Glu Val Met Thr Pro Arg Ile Glu Leu Val Val 
            260                 265                 270         


Ala Pro Ala Gly Val Thr Leu Lys Glu Ala Asn Glu Ile Leu Gln Arg 
        275                 280                 285             


Ser Lys Lys Gly Lys Leu Pro Ile Val Asn Asp Cys Asp Glu Leu Val 
    290                 295                 300                 


Ala Ile Ile Ala Arg Thr Asp Leu Lys Lys Asn Arg Asp Tyr Pro Leu 
305                 310                 315                 320 


Ala Ser Lys Asp Ser Gln Lys Gln Leu Leu Cys Gly Ala Ala Val Gly 
                325                 330                 335     


Thr Arg Glu Asp Asp Lys Tyr Arg Leu Asp Leu Leu Thr Gln Ala Gly 
            340                 345                 350         


Val Asp Val Ile Val Leu Asp Ser Ser Gln Gly Asn Ser Val Tyr Gln 
        355                 360                 365             


Ile Ala Met Val His Tyr Ile Lys Gln Lys Tyr Pro His Leu Gln Val 
    370                 375                 380                 


Ile Gly Gly Asn Val Val Thr Ala Ala Gln Ala Lys Asn Leu Ile Asp 
385                 390                 395                 400 


Ala Gly Val Asp Gly Leu Arg Val Gly Met Gly Cys Gly Ser Ile Cys 
                405                 410                 415     


Ile Thr Gln Glu Val Met Ala Cys Gly Arg Pro Gln Gly Thr Ala Val 
            420                 425                 430         


Tyr Lys Val Ala Glu Tyr Ala Arg Arg Phe Gly Val Pro Ile Ile Ala 
        435                 440                 445             


Asp Gly Gly Ile Gln Thr Val Gly His Val Val Lys Ala Leu Ala Leu 
    450                 455                 460                 


Gly Ala Ser Thr Val Met Met Gly Ser Leu Leu Ala Ala Thr Thr Glu 
465                 470                 475                 480 


Ala Pro Gly Glu Tyr Phe Phe Ser Asp Gly Val Arg Leu Lys Lys Tyr 
                485                 490                 495     


Arg Gly Met Gly Ser Leu Asp Ala Met Glu Lys Ser Ser Ser Ser Gln 
            500                 505                 510         


Lys Arg Tyr Phe Ser Glu Gly Asp Lys Val Lys Ile Ala Gln Gly Val 
        515                 520                 525             


Ser Gly Ser Ile Gln Asp Lys Gly Ser Ile Gln Lys Phe Val Pro Tyr 
    530                 535                 540                 


Leu Ile Ala Gly Ile Gln His Gly Cys Gln Asp Ile Gly Ala Arg Ser 
545                 550                 555                 560 


Leu Ser Val Leu Arg Ser Met Met Tyr Ser Gly Glu Leu Lys Phe Glu 
                565                 570                 575     


Lys Arg Thr Met Ser Ala Gln Ile Glu Gly Gly Val His Gly Leu His 
            580                 585                 590         


Ser Tyr Glu Lys Arg Leu Tyr 
        595                 


<210>  44
<211>  2981
<212>  DNA
<213>  Homo sapiens

<400>  44
gctgggtaaa tcccagagtc tcagccgcct aagtgtcttc cccggaggtg agattatctc       60

cgcctgtgct ggacacctcc ctttctcctg cagccatgga tgccgctctg ctcctgaacg      120

tggaaggggt caagaaaacc attctgcacg ggggcacggg cgagctccca aacttcatca      180

ccggatcccg agtgatcttt catttccgca ccatgaaatg tgatgaggag cggacagtca      240

ttgacgacag tcggcaggtg ggccagccca tgcacatcat catcggaaac atgttcaagc      300

tcgaggtctg ggagatcctg cttacctcca tgcgggtgca cgaggtggcc gagttctggt      360

gcgacaccat ccacacgggg gtctacccca tcctatcccg gagcctgagg cagatggccc      420

agggcaagga ccccacagag tggcacgtgc acacgtgcgg gctggccaac atgttcgcct      480

accacacgct gggctacgag gacctggacg agctgcagaa ggagcctcag cctctggtct      540

ttgtgatcga gctgctgcag gttgatgccc cgagtgatta ccagagggag acctggaacc      600

tgagcaatca tgagaagatg aaggcggtgc ccgtcctcca cggagaggga aatcggctct      660

tcaagctggg ccgctacgag gaggcctctt ccaagtacca ggaggccatc atctgcctaa      720

ggaacctgca gaccaaggag aagccatggg aggtgcagtg gctgaagctg gagaagatga      780

tcaatactct gatcctcaac tactgccagt gcctgctgaa gaaggaggag tactatgagg      840

tgctggagca caccagtgat attctccggc accacccagg catcgtgaag gcctactacg      900

tgcgtgcccg ggctcacgca gaggtgtgga atgaggccga ggccaaggcg gacctccaga      960

aagtgctgga gctggagccg tccatgcaga aggcggtgcg cagggagctg aggctgctgg     1020

agaaccgcat ggcggagaag caggaggagg agcggctgcg ctgccggaac atgctgagcc     1080

agggtgccac gcagcctccc gcagagccac ccacagagcc acccgcacag tcatccacag     1140

agccacctgc agagccaccc acagcaccat ctgcagagct gtccgcaggg ccccctgcag     1200

agccagccac agagccaccc ccgtccccag ggcactcgct gcagcactga gccccctgag     1260

gcccacagcc acccaggcag ggagcaagtg gcctggtcac ttctggttcg attgaccagg     1320

atcgtggtgt cactttttaa aatttaaaat taatttttga aatcaaagtc agacacaccc     1380

atggtaaaaa aaaaaaaaaa aacaatccca agggtacaga agagcttatg aataaaagta     1440

gttttctcct ctacccctct cattccttcc gtgccatggt tttaattgac cctgttttta     1500

attcttctgg tagttttctc tatttccaag taatctgttt aaatcagttt ctagatttta     1560

ccccatgtca atgacaaatg aggatttgat gctctgatcc tttctcatgc ctgatacccc     1620

tccctgtctc cccattttgg atagttacat ttgggggtca tctcggtgat ttttgtaact     1680

ttacgcagga cacttagagc tctctagaat cccactgact ttagtgggtc ttgatgtagg     1740

gtgggcaagc cccgacactg gagcttagcc tgagagggtt cttggcctcc cccaggaaag     1800

atttcaaagg caagcgccag tggtagggta gaagaaaaca gctgtggtcg ggcacggtgg     1860

ctcacgccta taatcccagc actttgggag gccgaggcgg gtggatcacc tgaggtcagg     1920

agttccagac cagcctggcc aacatggtga aacctcatct ctactaaaaa tacaaaaaaa     1980

ctagctgggc gtggtggcgg gcgcctataa tcccagctac ttgggaggct gaggcaggag     2040

aattgattga acctgggagg cggaggttgc agtgagccaa gatcacgtca ttgcactcca     2100

gcctggtcaa caagagtaaa acttcatctc aaaaaacaaa acaaaacaaa aacaacaaca     2160

aaaaacaaaa gaaaaacaaa caaaaccaaa accaaaacag ctgtattgaa gctgcagtgt     2220

tgcagctctg tgactgccct gcagagcagg gctaccccat aggcagcgag cagcagctca     2280

gggcagttct gcagtcagat ttatacccac ttttaattac atgtagatta aggagctgca     2340

tatacaaaga tttctaggga aggagtagta acttctgggt cctggggtct ttgccacgga     2400

acagggcagt atgccagggt gttgccacgg caatggtaaa ctgacatggc accctggggg     2460

tcatgcctta gggaaagccg cttccactcg cccctgtttt agctcatctt caagttagtc     2520

tggtgtccaa gctccaccgc ctgcctcagt ctggtgacct ccttctgtgt ctgatgagca     2580

tggcagcgtt gggaccttcc ccttccaact ctctccctcc tcttcgtcct ccctaaagga     2640

cgggtacgag gaggggctat cacgccagcg acatcctcta gcaccaccca ggtgtgtggg     2700

gtggggcagg ggggcgacga agtatccagc ccagggccac gtagtcaact gccaagggct     2760

tcctgggctt ctcttctgcc ccagagcttg tctccaccca gcaggggttc ccccagcgct     2820

aactgtatcc ctaaagttct gatgtacttt acttttccat cttccttgtt gttaacatct     2880

accttctgct ctgtaagcaa aactaaatct tctgtgcttt gtccataggt tgattctaca     2940

atctgaaaat caataaacag catttgcatg aaaaaaaaaa a                         2981


<210>  45
<211>  384
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Asp Ala Ala Leu Leu Leu Asn Val Glu Gly Val Lys Lys Thr Ile 
1               5                   10                  15      


Leu His Gly Gly Thr Gly Glu Leu Pro Asn Phe Ile Thr Gly Ser Arg 
            20                  25                  30          


Val Ile Phe His Phe Arg Thr Met Lys Cys Asp Glu Glu Arg Thr Val 
        35                  40                  45              


Ile Asp Asp Ser Arg Gln Val Gly Gln Pro Met His Ile Ile Ile Gly 
    50                  55                  60                  


Asn Met Phe Lys Leu Glu Val Trp Glu Ile Leu Leu Thr Ser Met Arg 
65                  70                  75                  80  


Val His Glu Val Ala Glu Phe Trp Cys Asp Thr Ile His Thr Gly Val 
                85                  90                  95      


Tyr Pro Ile Leu Ser Arg Ser Leu Arg Gln Met Ala Gln Gly Lys Asp 
            100                 105                 110         


Pro Thr Glu Trp His Val His Thr Cys Gly Leu Ala Asn Met Phe Ala 
        115                 120                 125             


Tyr His Thr Leu Gly Tyr Glu Asp Leu Asp Glu Leu Gln Lys Glu Pro 
    130                 135                 140                 


Gln Pro Leu Val Phe Val Ile Glu Leu Leu Gln Val Asp Ala Pro Ser 
145                 150                 155                 160 


Asp Tyr Gln Arg Glu Thr Trp Asn Leu Ser Asn His Glu Lys Met Lys 
                165                 170                 175     


Ala Val Pro Val Leu His Gly Glu Gly Asn Arg Leu Phe Lys Leu Gly 
            180                 185                 190         


Arg Tyr Glu Glu Ala Ser Ser Lys Tyr Gln Glu Ala Ile Ile Cys Leu 
        195                 200                 205             


Arg Asn Leu Gln Thr Lys Glu Lys Pro Trp Glu Val Gln Trp Leu Lys 
    210                 215                 220                 


Leu Glu Lys Met Ile Asn Thr Leu Ile Leu Asn Tyr Cys Gln Cys Leu 
225                 230                 235                 240 


Leu Lys Lys Glu Glu Tyr Tyr Glu Val Leu Glu His Thr Ser Asp Ile 
                245                 250                 255     


Leu Arg His His Pro Gly Ile Val Lys Ala Tyr Tyr Val Arg Ala Arg 
            260                 265                 270         


Ala His Ala Glu Val Trp Asn Glu Ala Glu Ala Lys Ala Asp Leu Gln 
        275                 280                 285             


Lys Val Leu Glu Leu Glu Pro Ser Met Gln Lys Ala Val Arg Arg Glu 
    290                 295                 300                 


Leu Arg Leu Leu Glu Asn Arg Met Ala Glu Lys Gln Glu Glu Glu Arg 
305                 310                 315                 320 


Leu Arg Cys Arg Asn Met Leu Ser Gln Gly Ala Thr Gln Pro Pro Ala 
                325                 330                 335     


Glu Pro Pro Thr Glu Pro Pro Ala Gln Ser Ser Thr Glu Pro Pro Ala 
            340                 345                 350         


Glu Pro Pro Thr Ala Pro Ser Ala Glu Leu Ser Ala Gly Pro Pro Ala 
        355                 360                 365             


Glu Pro Ala Thr Glu Pro Pro Pro Ser Pro Gly His Ser Leu Gln His 
    370                 375                 380                 


<210>  46
<211>  1934
<212>  DNA
<213>  Homo sapiens

<400>  46
gggcacaagc aatcctccct tctcagcttc ctgagtggcc aggactacag aggactgtat       60

gctgttctta aggactctct gcttcctgga caagctcaag ctaaggacta catctcccag      120

caggctgtgc tctgacagct cttggattta aataggattc tgggctctgc tcagagtcag      180

gctgctgctc agcacccagg acggagagga gcagagaagc agcagaagca gccaagagct      240

ggagccagac caggaacctg agccagagct ggggttgaag ctggagcagc agcaaaagca      300

acagcagcta cagaagttgg aacgatgctg gtcaccttgg gactgctcac ctccttcttc      360

tcgttcctgt atatggtagc tccatccatc aggaagttct ttgctggtgg agtgtgtaga      420

acaaatgtgc agcttcctgg caaggtagtg gtgatcactg gcgccaacac gggcattggc      480

aaggagacgg ccagagagct cgctagccga ggagcccgag tctatattgc ctgcagagat      540

gtactgaagg gggagtctgc tgccagtgaa atccgagtgg atacaaagaa ctcccaggtg      600

ctggtgcgga aattggacct atccgacacc aaatctatcc gagcctttgc tgagggcttt      660

ctggcagagg aaaagcagct ccatattctg atcaacaatg cgggagtaat gatgtgtcca      720

tattccaaga cagctgatgg ctttgaaacc cacctgggag tcaaccacct gggccacttc      780

ctcctcacct acctgctcct ggagcggcta aaggtgtctg cccctgcacg ggtggttaat      840

gtgtcctcgg tggctcacca cattggcaag attcccttcc acgacctcca gagcgagaag      900

cgctacagca ggggttttgc ctattgccac agcaagctgg ccaatgtgct ttttactcgt      960

gagctggcca agaggctcca aggcaccggg gtcaccacct acgcagtgca cccaggcgtc     1020

gtccgctctg agctggtccg gcactcctcc ctgctctgcc tgctctggcg gctcttctcc     1080

ccctttgtca agacggcacg ggagggggcg cagaccagcc tgcactgcgc cctggctgag     1140

ggcctggagc ccctgagtgg caagtacttc agtgactgca agaggacctg ggtgtctcca     1200

agggcccgaa ataacaaaac agctgagcgc ctatggaatg tcagctgtga gcttctagga     1260

atccggtggg agtagctggt ggaagagctg cagctttatc aggcccaatc catgccataa     1320

tgaacaggga ccaaggagaa ggccaaccct aaaggattgt cctcttggcc agctggtgct     1380

gcgaatcctg cctgctctga tcctcttgac ccttctggga atgtttgcac acctgacact     1440

cttgtgagac tggcttatgg catgagttgt ggacacctat agagtgttct tctctaagac     1500

ctggaaagtc agcaaccctc tgggggcagc aggactgggc agatcccagg ctgggcatgg     1560

gggtggcaga agagcccgag aaattgggtc agttccctca tcagcaccag aggctcagct     1620

gaggcaagaa gagcaccatc actgcctatt tctaggggct atacactcca actcttggtt     1680

gatctctttc tttttaaaaa tatttgccac caccctggag tctagaccaa cacacaaaga     1740

tcctggctaa ccctggccta tttagattcc ttcctctcac ctggaccttc ccatttcaat     1800

catgcagatg gtttcttttt gtaaagagtt ccgtttgcct ttcaattttt agagaaaata     1860

aagactgcat tcatctcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     1920

aaaaaaaaaa aaaa                                                       1934


<210>  47
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Leu Val Thr Leu Gly Leu Leu Thr Ser Phe Phe Ser Phe Leu Tyr 
1               5                   10                  15      


Met Val Ala Pro Ser Ile Arg Lys Phe Phe Ala Gly Gly Val Cys Arg 
            20                  25                  30          


Thr Asn Val Gln Leu Pro Gly Lys Val Val Val Ile Thr Gly Ala Asn 
        35                  40                  45              


Thr Gly Ile Gly Lys Glu Thr Ala Arg Glu Leu Ala Ser Arg Gly Ala 
    50                  55                  60                  


Arg Val Tyr Ile Ala Cys Arg Asp Val Leu Lys Gly Glu Ser Ala Ala 
65                  70                  75                  80  


Ser Glu Ile Arg Val Asp Thr Lys Asn Ser Gln Val Leu Val Arg Lys 
                85                  90                  95      


Leu Asp Leu Ser Asp Thr Lys Ser Ile Arg Ala Phe Ala Glu Gly Phe 
            100                 105                 110         


Leu Ala Glu Glu Lys Gln Leu His Ile Leu Ile Asn Asn Ala Gly Val 
        115                 120                 125             


Met Met Cys Pro Tyr Ser Lys Thr Ala Asp Gly Phe Glu Thr His Leu 
    130                 135                 140                 


Gly Val Asn His Leu Gly His Phe Leu Leu Thr Tyr Leu Leu Leu Glu 
145                 150                 155                 160 


Arg Leu Lys Val Ser Ala Pro Ala Arg Val Val Asn Val Ser Ser Val 
                165                 170                 175     


Ala His His Ile Gly Lys Ile Pro Phe His Asp Leu Gln Ser Glu Lys 
            180                 185                 190         


Arg Tyr Ser Arg Gly Phe Ala Tyr Cys His Ser Lys Leu Ala Asn Val 
        195                 200                 205             


Leu Phe Thr Arg Glu Leu Ala Lys Arg Leu Gln Gly Thr Gly Val Thr 
    210                 215                 220                 


Thr Tyr Ala Val His Pro Gly Val Val Arg Ser Glu Leu Val Arg His 
225                 230                 235                 240 


Ser Ser Leu Leu Cys Leu Leu Trp Arg Leu Phe Ser Pro Phe Val Lys 
                245                 250                 255     


Thr Ala Arg Glu Gly Ala Gln Thr Ser Leu His Cys Ala Leu Ala Glu 
            260                 265                 270         


Gly Leu Glu Pro Leu Ser Gly Lys Tyr Phe Ser Asp Cys Lys Arg Thr 
        275                 280                 285             


Trp Val Ser Pro Arg Ala Arg Asn Asn Lys Thr Ala Glu Arg Leu Trp 
    290                 295                 300                 


Asn Val Ser Cys Glu Leu Leu Gly Ile Arg Trp Glu 
305                 310                 315     


<210>  48
<211>  4729
<212>  DNA
<213>  Homo sapiens

<400>  48
agtctaggcc tccgcctccg ttaccctgga gcccaggtta ccgccgctgc cacccaggag       60

ccccgatcct cgcctctgtc ccatccttgt gttcaaacct cccgcatctc ggcaacctcg      120

gcacccgccc ggcagcctcc gcaggaacca ggcacccgct ctttggcggt cagacgccga      180

ggccccagct gggagtttgg tcctaagagg gaaggcaagg aggcgggacg ccgcatcggc      240

tctgctgaag agcctgcggg ttggaggtgg gctttgaagt gggcgtggag acggcggggg      300

aggtggaggt gcgagtataa atgatcaacc agaaattatc ttcaaaggaa taaaaccaga      360

agtatgtaaa taaaaagccc aagataaaga aacagaaaag ctgacactac atgaagcaga      420

gggcaaaaaa gtttatcttc tggatgccaa tgtgaattgt ggtctacaaa tacattgtgg      480

agaaaataga ttgcacagaa atgaatatta tcaggatctg aagactgtga aaatgttttt      540

cagtattgtc atagtctcct ctggagaaaa taatctgtga aattatgtga atagagacca      600

tttttcaaaa caatggggga aagagcagga agtccaggta ctgatcaaga aagaaaggca      660

ggcaaacacc attattctta cttatctgat tttgaaacgc cacagtcttc tggccgatca      720

tcgctggtca gttcttcacc tgcaagtgtt aggagaaaaa atcctaaaag acaaacttca      780

gatggccaag tacatcacca agcccctcgg aaaccaagcc ctaagggtct accaaacaga      840

aagggagtcc gagtgggatt tcgctcccag agcctcaata gagagccact tcggaaagat      900

actgatcttg ttacaaaacg gattctgtct gcaagactgc taaaaatcaa tgagttgcag      960

aatgaagtat ctgaactcca ggtcaagtta gctgagctgc taaaagaaaa taaatctttg     1020

aaaaggcttc agtacagaca ggagaaagcc ctgaataagt ttgaagatgc cgaaaatgaa     1080

atctcacaac ttatatttcg tcataacaat gagattacag cactcaaaga acgcttaaga     1140

aaatctcaag agaaagaacg ggcaactgag aaaagggtaa aagatacaga aagtgaacta     1200

tttaggacaa aattttcctt acagaaactg aaagagatct ctgaagctag acacctacct     1260

gaacgagatg atttggcaaa gaaactagtt tcagcagagt taaagttaga tgacaccgag     1320

agaagaatta aggagctatc gaaaaacctt gaactgagta ctaacagttt ccaacgacag     1380

ttgcttgctg aaaggaaaag ggcatatgag gctcatgatg aaaataaagt tcttcaaaag     1440

gaggtacagc gactatatca caaattaaag gaaaaggaga gagaactgga tataaaaaat     1500

atatattcta atcgtctgcc aaagtcctct ccaaataaag agaaagaact tgcattaaga     1560

aaaaatgctg catgccagag tgattttgca gacctgtgta caaaaggagt acaaaccatg     1620

gaagacttca agccagaaga atatccttta actccagaaa caattatgtg ttacgaaaac     1680

aaatgggaag aaccaggaca tcttactttg gacttgcaat ctcaaaagca agacaggcat     1740

ggagaagcag ggattctaaa cccaattatg gaaagagaag aaaaatttgt tacagatgaa     1800

gaactccatg tcgtaaaaca ggaggttgaa aagctggagg atgaatggga aagagaagaa     1860

cttgataaaa agcaaaaaga aaaggcatct ttactggaaa gagaagaaaa gccagagtgg     1920

gaaactggaa ggtaccaact aggaatgtat ccaattcaga atatggataa attgcaagga     1980

gaggaagaag aaagactgaa gagagaaatg ctacttgcta aactgaatga aattgacaga     2040

gaactccaag attctcgaaa tctaaaatac cctgttttgc cattgttacc tgattttgaa     2100

tcaaaactac actccccaga gagaagcccc aaaacataca ggttctctga atcctcagag     2160

agattattta atgggcatca tttgcaagac atcagtttct caactccaaa aggagaaggt     2220

cagaattcag gaaatgttag aagtccagcc tcccctaatg agttcgcatt tggtagctac     2280

gtgccttcgt ttgcaaaaac atcagagagg tcaaatccat ttagtcaaaa aagtagtttt     2340

ttggatttcc aaagaaacag tatggaaaaa cttagtaaag atggtgtaga tttaattaca     2400

agaaaagaga aaaaagctaa tttgatggaa cagttatttg gtgccagtgg tagcagcacc     2460

atttcctcca aaagcagtga cccaaattct gtggcttcca gtaaaggaga cattgaccct     2520

ctaaattttc tccctgggaa taaaggcagc agagatcaag aacatgatga agatgaaggc     2580

tttttcctca gtgaaggaag aagttttaat ccaaataggc accgattaaa acatgcagac     2640

gataaaccag cagtaaaagc agctgattct gtagaagatg aaattgaaga agtagcactg     2700

agatgactga ctagagtata cattttttct aattgtaaat attgaaatat tttaatacag     2760

tatttattat aaacatttag actttttaat gctaaaatgt ccttattaag gaatgatttt     2820

taatagctaa atacaatgca gttaaaaaga agtagatcat acatacacca catagatagt     2880

ttgccaagaa tgaaggaggc ttttttgaat gaaaccaaaa ataaaaatat gtcttgaaaa     2940

atgaaataga ttttaactct tcatccagtg ctatggcaag tttaactgca ctggaggtgg     3000

tattcctttt ctacttttat tcctatttat gtatttattt ttaatcatat tctcactgtg     3060

ctaaatacag tcttcccact aattgttgaa tgaaaattaa gggtgaaagt ctgtgttggg     3120

aagtgtagct ccggatggtg gagaaccagt gcttcttagg agcccttccc tttatggata     3180

gggccagggg tccctatctt acgtggcagt cctaagctac tcttgagtga tagcagtcac     3240

aacattggga tttcccattc ctctgaaagt acccacagct aaacactact catttcccaa     3300

tttcagtatt tactgaaatc acttacctac aattctgtta gaatattatg ttgagttcgg     3360

aagacatttc tctgtttgca aggacagtta gttgctctct gtcatagccc gcagaagctt     3420

ggctacagtg taattcctct ccttgttctc ctacactctt tgtatctcag tgactgggtg     3480

taagatttca tgccaaatgc aaggaatagt ggaaatacat accaactgca aagaatagaa     3540

aaactttatc ccaatatatt atagaaagat cttcagttca attatgtcca gagtaatata     3600

atttggcaat gttaatgctt ttaagatttg aacttgtcct caaaccaagg agacaacaat     3660

agtgtaatac tattggactt acaggattag ttttaaagca actttgaata gaagtgtttc     3720

agacatagga cttctgcctt gttgactaga gtggatagtt ttctgtttaa atgcattggt     3780

cttttggctg tttgtaattc acttcagctt atagagaagt tgatgacctt ggatcatgct     3840

gggtatgatt ggtctttaaa aagcagtaat ataccaccag cccaaggaga aaacattgtt     3900

aaaatgaaga gtggtggaaa tagtgtgttg ggaagaataa aaaatttaga ttggcactta     3960

ttctaaagtg agctgttttt ttcaagaatt tactagcatt tgctcgtagt atgatttctg     4020

acgccagtca tatatactga tgaggggaag gagttactgt gttattctga gttcttataa     4080

atgcatatta ttgaatttca ttgcatgact atttgtcaag acttacctgg ttaggtctcc     4140

aattaaaaga tgtaccacct gtcatcttct aaattgtgtt cctttcattt attgggaaca     4200

gaatctctca aaagtgctaa actatattaa aaagttttct taatagattt gtatgtctga     4260

tatgtataac catttactat aatatgttgc aaatcattct aatatatgta aaacaatatt     4320

atttgtaatg cagttattgg taaaatatta tgtaatgtta attttgttcc tagctgctaa     4380

tttttctgcc aaaagtattc taattttcag gttgttttaa aggcttttaa aactttttag     4440

ttaagttttt tattcacgtc atttaaatta gttttttgct ttttttctac ctgataatct     4500

ctttaacaag atgcaacaag acagaattat taaaattaaa cctaaagtta agttacagat     4560

ttaaaggcat tatgatatta agcattaaaa ttggagatta aaatgtacaa aacagggttt     4620

tccttatgaa caaaccttac agggtaaatt gttttttttt ctaaatgtca ttaaatttat     4680

ttgtactcag aactgttact aataaaaatt aaaaatgcaa aaaaaaaaa                 4729


<210>  49
<211>  697
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Gly Glu Arg Ala Gly Ser Pro Gly Thr Asp Gln Glu Arg Lys Ala 
1               5                   10                  15      


Gly Lys His His Tyr Ser Tyr Leu Ser Asp Phe Glu Thr Pro Gln Ser 
            20                  25                  30          


Ser Gly Arg Ser Ser Leu Val Ser Ser Ser Pro Ala Ser Val Arg Arg 
        35                  40                  45              


Lys Asn Pro Lys Arg Gln Thr Ser Asp Gly Gln Val His His Gln Ala 
    50                  55                  60                  


Pro Arg Lys Pro Ser Pro Lys Gly Leu Pro Asn Arg Lys Gly Val Arg 
65                  70                  75                  80  


Val Gly Phe Arg Ser Gln Ser Leu Asn Arg Glu Pro Leu Arg Lys Asp 
                85                  90                  95      


Thr Asp Leu Val Thr Lys Arg Ile Leu Ser Ala Arg Leu Leu Lys Ile 
            100                 105                 110         


Asn Glu Leu Gln Asn Glu Val Ser Glu Leu Gln Val Lys Leu Ala Glu 
        115                 120                 125             


Leu Leu Lys Glu Asn Lys Ser Leu Lys Arg Leu Gln Tyr Arg Gln Glu 
    130                 135                 140                 


Lys Ala Leu Asn Lys Phe Glu Asp Ala Glu Asn Glu Ile Ser Gln Leu 
145                 150                 155                 160 


Ile Phe Arg His Asn Asn Glu Ile Thr Ala Leu Lys Glu Arg Leu Arg 
                165                 170                 175     


Lys Ser Gln Glu Lys Glu Arg Ala Thr Glu Lys Arg Val Lys Asp Thr 
            180                 185                 190         


Glu Ser Glu Leu Phe Arg Thr Lys Phe Ser Leu Gln Lys Leu Lys Glu 
        195                 200                 205             


Ile Ser Glu Ala Arg His Leu Pro Glu Arg Asp Asp Leu Ala Lys Lys 
    210                 215                 220                 


Leu Val Ser Ala Glu Leu Lys Leu Asp Asp Thr Glu Arg Arg Ile Lys 
225                 230                 235                 240 


Glu Leu Ser Lys Asn Leu Glu Leu Ser Thr Asn Ser Phe Gln Arg Gln 
                245                 250                 255     


Leu Leu Ala Glu Arg Lys Arg Ala Tyr Glu Ala His Asp Glu Asn Lys 
            260                 265                 270         


Val Leu Gln Lys Glu Val Gln Arg Leu Tyr His Lys Leu Lys Glu Lys 
        275                 280                 285             


Glu Arg Glu Leu Asp Ile Lys Asn Ile Tyr Ser Asn Arg Leu Pro Lys 
    290                 295                 300                 


Ser Ser Pro Asn Lys Glu Lys Glu Leu Ala Leu Arg Lys Asn Ala Ala 
305                 310                 315                 320 


Cys Gln Ser Asp Phe Ala Asp Leu Cys Thr Lys Gly Val Gln Thr Met 
                325                 330                 335     


Glu Asp Phe Lys Pro Glu Glu Tyr Pro Leu Thr Pro Glu Thr Ile Met 
            340                 345                 350         


Cys Tyr Glu Asn Lys Trp Glu Glu Pro Gly His Leu Thr Leu Asp Leu 
        355                 360                 365             


Gln Ser Gln Lys Gln Asp Arg His Gly Glu Ala Gly Ile Leu Asn Pro 
    370                 375                 380                 


Ile Met Glu Arg Glu Glu Lys Phe Val Thr Asp Glu Glu Leu His Val 
385                 390                 395                 400 


Val Lys Gln Glu Val Glu Lys Leu Glu Asp Glu Trp Glu Arg Glu Glu 
                405                 410                 415     


Leu Asp Lys Lys Gln Lys Glu Lys Ala Ser Leu Leu Glu Arg Glu Glu 
            420                 425                 430         


Lys Pro Glu Trp Glu Thr Gly Arg Tyr Gln Leu Gly Met Tyr Pro Ile 
        435                 440                 445             


Gln Asn Met Asp Lys Leu Gln Gly Glu Glu Glu Glu Arg Leu Lys Arg 
    450                 455                 460                 


Glu Met Leu Leu Ala Lys Leu Asn Glu Ile Asp Arg Glu Leu Gln Asp 
465                 470                 475                 480 


Ser Arg Asn Leu Lys Tyr Pro Val Leu Pro Leu Leu Pro Asp Phe Glu 
                485                 490                 495     


Ser Lys Leu His Ser Pro Glu Arg Ser Pro Lys Thr Tyr Arg Phe Ser 
            500                 505                 510         


Glu Ser Ser Glu Arg Leu Phe Asn Gly His His Leu Gln Asp Ile Ser 
        515                 520                 525             


Phe Ser Thr Pro Lys Gly Glu Gly Gln Asn Ser Gly Asn Val Arg Ser 
    530                 535                 540                 


Pro Ala Ser Pro Asn Glu Phe Ala Phe Gly Ser Tyr Val Pro Ser Phe 
545                 550                 555                 560 


Ala Lys Thr Ser Glu Arg Ser Asn Pro Phe Ser Gln Lys Ser Ser Phe 
                565                 570                 575     


Leu Asp Phe Gln Arg Asn Ser Met Glu Lys Leu Ser Lys Asp Gly Val 
            580                 585                 590         


Asp Leu Ile Thr Arg Lys Glu Lys Lys Ala Asn Leu Met Glu Gln Leu 
        595                 600                 605             


Phe Gly Ala Ser Gly Ser Ser Thr Ile Ser Ser Lys Ser Ser Asp Pro 
    610                 615                 620                 


Asn Ser Val Ala Ser Ser Lys Gly Asp Ile Asp Pro Leu Asn Phe Leu 
625                 630                 635                 640 


Pro Gly Asn Lys Gly Ser Arg Asp Gln Glu His Asp Glu Asp Glu Gly 
                645                 650                 655     


Phe Phe Leu Ser Glu Gly Arg Ser Phe Asn Pro Asn Arg His Arg Leu 
            660                 665                 670         


Lys His Ala Asp Asp Lys Pro Ala Val Lys Ala Ala Asp Ser Val Glu 
        675                 680                 685             


Asp Glu Ile Glu Glu Val Ala Leu Arg 
    690                 695         


<210>  50
<211>  3771
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pR2.1 from ATG to L-opsin gene

<400>  50
ccagggtgag attatgaggc tgagctgaga atatcaagac tgtaccgagt agggggcctt       60

ggcaagtgtg gagagcccgg cagctggggc agagggcgga gtacggtgtg cgtttacgga      120

cctcttcaaa cgaggtagga aggtcagaag tcaaaaaggg aacaaatgat gtttaaccac      180

acaaaaatga aaatccaatg gttggatatc cattccaaat acacaaaggc aacggataag      240

tgatccgggc caggcacaga aggccatgca cccgtaggat tgcactcaga gctcccaaat      300

gcataggaat agaagggtgg gtgcaggagg ctgaggggtg gggaaagggc atgggtgttt      360

catgaggaca gagcttccgt ttcatgcaat gaaaagagtt tggagacgga tggtggtgac      420

tggactatac acttacacac ggtagcgatg gtacactttg tattatgtat attttaccac      480

gatcttttta aagtgtcaaa ggcaaatggc caaatggttc cttgtcctat agctgtagca      540

gccatcggct gttagtgaca aagcccctga gtcaagatga cagcagcccc cataactcct      600

aatcggctct cccgcgtgga gtcatttagg agtagtcgca ttagagacaa gtccaacatc      660

taatcttcca ccctggccag ggccccagct ggcagcgagg gtgggagact ccgggcagag      720

cagagggcgc tgacattggg gcccggcctg gcttgggtcc ctctggcctt tccccagggg      780

ccctctttcc ttggggcttt cttgggccgc cactgctccc gctcctctcc ccccatccca      840

ccccctcacc ccctcgttct tcatatcctt ctctagtgct ccctccactt tcatccaccc      900

ttctgcaaga gtgtgggacc acaaatgagt tttcacctgg cctggggaca cacgtgcccc      960

cacaggtgct gagtgacttt ctaggacagt aatctgcttt aggctaaaat gggacttgat     1020

cttctgttag ccctaatcat caattagcag agccggtgaa ggtgcagaac ctaccgcctt     1080

tccaggcctc ctcccacctc tgccacctcc actctccttc ctgggatgtg ggggctggca     1140

cacgtgtggc ccagggcatt ggtgggattg cactgagctg ggtcattagc gtaatcctgg     1200

acaagggcag acagggcgag cggagggcca gctccggggc tcaggcaagg ctgggggctt     1260

cccccagaca ccccactcct cctctgctgg acccccactt catagggcac ttcgtgttct     1320

caaagggctt ccaaatagca tggtggcctt ggatgcccag ggaagcctca gagttgctta     1380

tctccctcta gacagaaggg gaatctcggt caagagggag aggtcgccct gttcaaggcc     1440

acccagccag ctcatggcgg taatgggaca aggctggcca gccatcccac cctcagaagg     1500

gacccggtgg ggcaggtgat ctcagaggag gctcacttct gggtctcaca ttcttggatc     1560

cggttccagg cctcggccct aaatagtctc cctgggcttt caagagaacc acatgagaaa     1620

ggaggattcg ggctctgagc agtttcacca cccacccccc agtctgcaaa tcctgacccg     1680

tgggtccacc tgccccaaag gcggacgcag gacagtagaa gggaacagag aacacataaa     1740

cacagagagg gccacagcgg ctcccacagt caccgccacc ttcctggcgg ggatgggtgg     1800

ggcgtctgag tttggttccc agcaaatccc tctgagccgc ccttgcgggc tcgcctcagg     1860

agcaggggag caagaggtgg gaggaggagg tctaagtccc aggcccaatt aagagatcag     1920

gtagtgtagg gtttgggagc ttttaaggtg aagaggcccg ggctgatccc acaggccagt     1980

ataaagcgcc gtgaccctca ggtgatgcgc cagggccggc tgccgtcggg gacagggctt     2040

tccatagcca tgctagagga tccggtactc gaggaactga aaaaccagaa agttaactgg     2100

taagtttagt ctttttgtct tttatttcag gtcccggatc cggtggtggt gcaaatcaaa     2160

gaactgctcc tcagtggatg ttgcctttac ttctaggcct gtacggaagt gttacttctg     2220

ctctaaaagc tgcggaattg tacccgcggc cgcgggacag ggctttccat agccatggcc     2280

cagcagtgga gcctccaaag gctcgcaggc cgccatccgc aggacagcta tgaggacagc     2340

acccagtcca gcatcttcac ctacaccaac agcaactcca ccagaggccc cttcgaaggc     2400

ccgaattacc acatcgctcc cagatgggtg taccacctca ccagtgtctg gatgatcttt     2460

gtggtcactg catccgtctt cacaaatggg cttgtgctgg cggccaccat gaagttcaag     2520

aagctgcgcc acccgctgaa ctggatcctg gtgaacctgg cggtcgctga cctagcagag     2580

accgtcatcg ccagcactat cagcattgtg aaccaggtct ctggctactt cgtgctgggc     2640

caccctatgt gtgtcctgga gggctacacc gtctccctgt gtgggatcac aggtctctgg     2700

tctctggcca tcatttcctg ggagagatgg atggtggtct gcaagccctt tggcaatgtg     2760

agatttgatg ccaagctggc catcgtgggc attgccttct cctggatctg gtctgctgtg     2820

tggacagccc cgcccatctt tggttggagc aggtactggc cccacggcct gaagacttca     2880

tgcggcccag acgtgttcag cggcagctcg taccccgggg tgcagtctta catgattgtc     2940

ctcatggtca cctgctgcat catcccactc gctatcatca tgctctgcta cctccaagtg     3000

tggctggcca tccgagcggt ggcaaagcag cagaaagagt ctgaatccac ccagaaggca     3060

gagaaggaag tgacgcgcat ggtggtggtg atgatctttg cgtactgcgt ctgctgggga     3120

ccctacacct tcttcgcatg ctttgctgct gccaaccctg gttacgcctt ccaccctttg     3180

atggctgccc tgccggccta ctttgccaaa agtgccacta tctacaaccc cgttatctat     3240

gtctttatga accggcagtt tcgaaactgc atcttgcagc ttttcgggaa gaaggttgac     3300

gatggctctg aactctccag cgcctccaaa acggaggtct caactgtgtc ctcgacccag     3360

gtagggccta actgaggtct gcctcctacc catcccgccc accggggctt tggccacctc     3420

tcctttcccc ctccttctcc atccctgtaa aataaatgta atttatcttt gccaaaacca     3480

aaaaaaacgg aattcgtaat catgtcatag ctgtttcctg tgtgaaattg ttatccgctc     3540

acaattccac acaacatacg aggcggccgc gcggatccag acatgataag atacattgat     3600

gagtttggac aaaccacaac tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt     3660

gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat     3720

tgcattcatt ttatgtttca ggttcagggg gaggtgtggg aggtttttta g              3771


<210>  51
<211>  36
<212>  DNA
<213>  Homo sapiens

<400>  51
gacttgatct tctgttagcc ctaatcatca attagc                                 36


<210>  52
<211>  1565
<212>  DNA
<213>  Homo sapiens

<400>  52
cctacagcag ccagggtgag attatgaggc tgagctgaga atatcaagac tgtaccgagt       60

agggggcctt ggcaagtgtg gagagcccgg cagctggggc agagggcgga gtacggtgtg      120

cgtttacgga cctcttcaaa cgaggtagga aggtcagaag tcaaaaaggg aacaaatgat      180

gtttaaccac acaaaaatga aaatccaatg gttggatatc cattccaaat acacaaaggc      240

aacggataag tgatccgggc caggcacaga aggccatgca cccgtaggat tgcactcaga      300

gctcccaaat gcataggaat agaagggtgg gtgcaggagg ctgaggggtg gggaaagggc      360

atgggtgttt catgaggaca gagcttccgt ttcatgcaat gaaaagagtt tggagacgga      420

tggtggtgac tggactatac acttacacac ggtagcgatg gtacactttg tattatgtat      480

attttaccac gatcttttta aagtgtcaaa ggcaaatggc caaatggttc cttgtcctat      540

agctgtagca gccatcggct gttagtgaca aagcccctga gtcaagatga cagcagcccc      600

cataactcct aatcggctct cccgcgtgga gtcatttagg agtagtcgca ttagagacaa      660

gtccaacatc taatcttcca ccctggccag ggccccagct ggcagcgagg gtgggagact      720

ccgggcagag cagagggcgc tgacattggg gcccggcctg gcttgggtcc ctctggcctt      780

tccccagggg ccctctttcc ttggggcttt cttgggccgc cactgctccc gctcctctcc      840

ccccatccca ccccctcacc ccctcgttct tcatatcctt ctctagtgct ccctccactt      900

tcatccaccc ttctgcaaga gtgtgggacc acaaatgagt tttcacctgg cctggggaca      960

cacgtgcccc cacaggtgct gagtgacttt ctaggacagt aatctgcttt aggctaaaat     1020

gggacttgat cttctgttag ccctaatcat caattagcag agccggtgaa ggtgcagaac     1080

ctaccgcctt tccaggcctc ctcccacctc tgccacctcc actctccttc ctgggatgtg     1140

ggggctggca cacgtgtggc ccagggcatt ggtgggattg cactgagctg ggtcattagc     1200

gtaatcctgg acaagggcag acagggcgag cggagggcca gctccggggc tcaggcaagg     1260

ctgggggctt cccccagaca ccccactcct cctctgctgg acccccactt catagggcac     1320

ttcgtgttct caaagggctt ccaaatagca tggtggcctt ggatgcccag ggaagcctca     1380

gagttgctta tctccctcta gacagaaggg gaatctcggt caagagggag aggtcgccct     1440

gttcaaggcc acccagccag ctcatggcgg taatgggaca aggctggcca gccatcccac     1500

cctcagaagg gacccggtgg ggcaggtgat ctcagaggag gctcacttct gggtctcaca     1560

ttctt                                                                 1565


<210>  53
<211>  491
<212>  DNA
<213>  Homo sapiens

<400>  53
ggttccaggc ctcggcccta aatagtctcc ctgggctttc aagagaacca catgagaaag       60

gaggattcgg gctctgagca gtttcaccac ccacccccca gtctgcaaat cctgacccgt      120

gggtccacct gccccaaagg cggacgcagg acagtagaag ggaacagaga acacataaac      180

acagagaggg ccacagcggc tcccacagtc accgccacct tcctggcggg gatgggtggg      240

gcgtctgagt ttggttccca gcaaatccct ctgagccgcc cttgcgggct cgcctcagga      300

gcaggggagc aagaggtggg aggaggaggt ctaagtccca ggcccaatta agagatcagg      360

tagtgtaggg tttgggagct tttaaggtga agaggcccgg gctgatccca caggccagta      420

taaagcgccg tgaccctcag gtgatgcgcc agggccggct gccgtcgggg acagggcttt      480

ccatagccat g                                                           491


<210>  54
<211>  491
<212>  DNA
<213>  Homo sapiens

<400>  54
agtagaaacg gggtttcacc atgttagtca ggctggtcgg gaactcctga cctcaggaga       60

tctacccgcc ttggcctccc aaagtgctgg gattacaggc gtgtgccact gtgcccagcc      120

actttttttt agacagagtc ttggtctgtt gcccaggcta gagttcagtg gcgccatctc      180

agctcactgc aacctccgcc tcccagattc aagcgattct cctgcctcga cctcccagta      240

gctgggatta caggtttcca gcaaatccct ctgagccgcc cccgggggct cgcctcagga      300

gcaaggaagc aaggggtggg aggaggaggt ctaagtccca ggcccaatta agagatcaga      360

tggtgtagga tttgggagct tttaaggtga agaggcccgg gctgatccca ctggccggta      420

taaagcaccg tgaccctcag gtgacgcacc agggccggct gccgtcgggg acagggcttt      480

ccatagccat g                                                           491


<210>  55
<211>  239
<212>  DNA
<213>  Homo sapiens

<400>  55
ggtttccagc aaatccctct gagccgcccc cgggggctcg cctcaggagc aaggaagcaa       60

ggggtgggag gaggaggtct aagtcccagg cccaattaag agatcagatg gtgtaggatt      120

tgggagcttt taaggtgaag aggcccgggc tgatcccact ggccggtata aagcaccgtg      180

accctcaggt gacgcaccag ggccggctgc cgtcggggac agggctttcc atagccatg       239


<210>  56
<211>  169
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized 5'UTR

<400>  56
gccagggccg gcugccgucg gggacagggc uuuccauagc caugcuagag gauccgguac       60

ucgaggaacu gaaaaaccag aaaguuaacu ggccuguacg gaaguguuac uucugcucua      120

aaagcugcgg aauuguaccc gcggccgcgg gacagggcuu uccauagcc                  169


<210>  57
<211>  77
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthesized 5'UTR

<400>  57
gcaccagggc cggcugccgu cggggacagg gcuuuccaua gcccaggccu cuagagagga       60

guaucagugc cgccacc                                                      77


<210>  58
<211>  213
<212>  DNA
<213>  Homo sapiens

<400>  58
aacggctagc ctgaggagct gctgcgacag tccactacct ttttcgagag tgactcccgt       60

tgtcccaagg cttcccagag cgaacctgtg cggctgcagg caccggcgcg tcgagtttcc      120

ggcgtccgga aggaccgagc tcttctcgcg gatccagtgt tccgtttcca gcccccaatc      180

tcagagccga gccgacagag agcagggaac cgc                                   213


<210>  59
<211>  97
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pR2.1 intron sequence

<400>  59
gtaagtttag tctttttgtc ttttatttca ggtcccggat ccggtggtgg tgcaaatcaa       60

agaactgctc ctcagtggat gttgccttta cttctag                                97


<210>  60
<211>  133
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MNTC intron sequence

<400>  60
gtaagtatca aggttacaag acaggtttaa ggagaccaat agaaactggg cttgtcgaga       60

cagagaagac tcttgcgttt ctgataggca cctattggtc ttactgacat ccactttgcc      120

tttctctcca cag                                                         133


<210>  61
<211>  1095
<212>  DNA
<213>  Homo sapiens

<400>  61
atggcccagc agtggagcct ccaaaggctc gcaggccgcc atccgcagga cagctatgag       60

gacagcaccc agtccagcat cttcacctac accaacagca actccaccag aggccccttc      120

gaaggcccga attaccacat cgctcccaga tgggtgtacc acctcaccag tgtctggatg      180

atctttgtgg tcactgcatc cgtcttcaca aatgggcttg tgctggcggc caccatgaag      240

ttcaagaagc tgcgccaccc gctgaactgg atcctggtga acctggcggt cgctgaccta      300

gcagagaccg tcatcgccag cactatcagc attgtgaacc aggtctctgg ctacttcgtg      360

ctgggccacc ctatgtgtgt cctggagggc tacaccgtct ccctgtgtgg gatcacaggt      420

ctctggtctc tggccatcat ttcctgggag aggtggctgg tggtgtgcaa gccctttggc      480

aatgtgagat ttgatgccaa gctggccatc gtgggcattg ccttctcctg gatctggtct      540

gctgtgtgga cagccccgcc catctttggt tggagcaggt actggcccca cggcctgaag      600

acttcatgcg gcccagacgt gttcagcggc agctcgtacc ccggggtgca gtcttacatg      660

attgtcctca tggtcacctg ctgcatcatc ccactcgcta tcatcatgct ctgctacctc      720

caagtgtggc tggccatccg agcggtggca aagcagcaga aagagtctga atccacccag      780

aaggcagaga aggaagtgac gcgcatggtg gtggtgatga tctttgcgta ctgcgtctgc      840

tggggaccct acaccttctt cgcatgcttt gctgctgcca accctggtta cgccttccac      900

cctttgatgg ctgccctgcc ggcctacttt gccaaaagtg ccactatcta caaccccgtt      960

atctatgtct ttatgaaccg gcagtttcga aactgcatct tgcagctttt cgggaagaag     1020

gttgacgatg gctctgaact ctccagcgcc tccaaaacgg aggtctcatc tgtgtcctcg     1080

gtatcgcctg catga                                                      1095


<210>  62
<211>  1095
<212>  DNA
<213>  Homo sapiens

<400>  62
atggcccagc agtggagcct ccaaaggctc gcaggccgcc atccgcagga cagctatgag       60

gacagcaccc agtccagcat cttcacctac accaacagca actccaccag aggccccttc      120

gaaggcccga attaccacat cgctcccaga tgggtgtacc acctcaccag tgtctggatg      180

atctttgtgg tcattgcatc cgtcttcaca aatgggcttg tgctggcggc caccatgaag      240

ttcaagaagc tgcgccaccc gctgaactgg atcctggtga acctggcggt cgctgacctg      300

gcagagaccg tcatcgccag cactatcagc gttgtgaacc aggtctatgg ctacttcgtg      360

ctgggccacc ctatgtgtgt cctggagggc tacaccgtct ccctgtgtgg gatcacaggt      420

ctctggtctc tggccatcat ttcctgggag agatggatgg tggtctgcaa gccctttggc      480

aatgtgagat ttgatgccaa gctggccatc gtgggcattg ccttctcctg gatctgggct      540

gctgtgtgga cagccccgcc catctttggt tggagcaggt actggcccca cggcctgaag      600

acttcatgcg gcccagacgt gttcagcggc agctcgtacc ccggggtgca gtcttacatg      660

attgtcctca tggtcacctg ctgcatcacc ccactcagca tcatcgtgct ctgctacctc      720

caagtgtggc tggccatccg agcggtggca aagcagcaga aagagtctga atccacccag      780

aaggcagaga aggaagtgac gcgcatggtg gtggtgatgg tcctggcatt ctgcttctgc      840

tggggaccat acgccttctt cgcatgcttt gctgctgcca accctggcta ccccttccac      900

cctttgatgg ctgccctgcc ggccttcttt gccaaaagtg ccactatcta caaccccgtt      960

atctatgtct ttatgaaccg gcagtttcga aactgcatct tgcagctttt cgggaagaag     1020

gttgacgatg gctctgaact ctccagcgcc tccaaaacgg aggtctcatc tgtgtcctcg     1080

gtatcgcctg catga                                                      1095


<210>  63
<211>  1092
<212>  DNA
<213>  Homo sapiens

<400>  63
atggcccagc agtggagcct ccaaaggctc gcaggccgcc atccgcagga cagctatgag       60

gacagcaccc agtccagcat cttcacctac accaacagca actccaccag aggccccttc      120

gaaggcccga attaccacat cgctcccaga tgggtgtacc acctcaccag tgtctggatg      180

atctttgtgg tcattgcatc cgtcttcaca aatgggcttg tgctggcggc caccatgaag      240

ttcaagaagc tgcgccaccc gctgaactgg atcctggtga acctggcggt cgctgacctg      300

gcagagaccg tcatcgccag cactatcagc gttgtgaacc aggtctatgg ctacttcgtg      360

ctgggccacc ctatgtgtgt cctggagggc tacaccgtct ccctgtgtgg gatcacaggt      420

ctctggtctc tggccatcat ttcctgggag agatggctgg tggtctgcaa gccctttggc      480

aatgtgagat ttgatgccaa gctggccatc gtgggcattg ccttctcctg gatctgggct      540

gctgtgtgga cagccccgcc catctttggt tggagcaggt actggcccta cggcctgaag      600

acttcatgcg gcccagacgt gttcagcggc agctcgtacc ccggggtgca gtcttacatg      660

attgtcctca tggtcacctg ctgcatcacc ccactcagca tcatcgtgct ctgctacctc      720

caagtgtggc tggccatccg agcggtggca aagcagcaga aagagtctga atccacccag      780

aaggcagaga aggaagtgac gcgcatggtg gtggtgatgg tcctggcatt ctgcttctgc      840

tggggaccat acgccttctt cgcatgcttt gctgctgcca accctggcta ccccttccac      900

cctttgatgg ctgccctgcc gtcctacttt gccaaaagtg ccactatcta caaccccgtt      960

atctatgtct ttatgaaccg gcagtttcga aactgcatct tgcagctttt cgggaagaag     1020

gttgacgatg gctctgaact ctccagcgcc tccaaaacgg aggtctcatc tgtgtcctcg     1080

gtatcgcctg ca                                                         1092


<210>  64
<211>  1092
<212>  DNA
<213>  Homo sapiens

<400>  64
atggcccagc agtggagcct gcagcggctg gccggccggc acccccagga cagctacgag       60

gacagcaccc agagcagcat cttcacctac accaacagca acagcacccg gggccccttc      120

gagggcccca actaccacat cgccccccgg tgggtgtacc acctgaccag cgtgtggatg      180

atcttcgtgg tgatcgccag cgtgttcacc aacggcctgg tgctggccgc caccatgaag      240

ttcaagaagc tgcggcaccc cctgaactgg atcctggtga acctggccgt ggccgacctg      300

gccgagaccg tgatcgccag caccatcagc gtggtgaacc aggtgtacgg ctacttcgtg      360

ctgggccacc ccatgtgcgt gctggagggc tacaccgtga gcctgtgcgg catcaccggc      420

ctgtggagcc tggccatcat cagctgggag cggtggctgg tggtgtgcaa gcccttcggc      480

aacgtgcggt tcgacgccaa gctggccatc gtgggcatcg ccttcagctg gatctgggcc      540

gccgtgtgga ccgccccccc catcttcggc tggagccggt actggcccta cggcctgaag      600

accagctgcg gccccgacgt gttcagcggc agcagctacc ccggcgtgca gagctacatg      660

atcgtgctga tggtgacctg ctgcatcacc cccctgagca tcatcgtgct gtgctacctg      720

caggtgtggc tggccatccg ggccgtggcc aagcagcaga aggagagcga gagcacccag      780

aaggccgaga aggaggtgac ccggatggtg gtggtgatgg tgctggcctt ctgcttctgc      840

tggggcccct acgccttctt cgcctgcttc gccgccgcca accccggcta ccccttccac      900

cccctgatgg ccgccctgcc cagctacttc gccaagagcg ccaccatcta caaccccgtg      960

atctacgtgt tcatgaaccg gcagttccgg aactgcatcc tgcagctgtt cggcaagaag     1020

gtggacgacg gcagcgagct gagcagcgcc agcaagaccg aggtgagcag cgtgagcagc     1080

gtgagccccg cc                                                         1092


<210>  65
<211>  1092
<212>  DNA
<213>  Homo sapiens

<400>  65
atggcccagc agtggagcct gcagcggctg gccggccggc acccccagga cagctacgag       60

gacagcaccc agagcagcat cttcacctac accaacagca acagcacccg gggccccttc      120

gagggcccca actaccacat cgccccccgg tgggtgtacc acctgaccag cgtgtggatg      180

atcttcgtgg tgatcgccag cgtgttcacc aacggcctgg tgctggccgc cacaatgaag      240

ttcaagaagc tgcggcaccc cctgaactgg atcctggtga acctggccgt ggccgacctg      300

gccgagaccg tgatcgccag cacaatcagc gtggtgaacc aggtgtacgg ctacttcgtg      360

ctgggccacc ccatgtgcgt gctggagggc tacaccgtga gcctgtgcgg catcaccggc      420

ctgtggagcc tggccatcat cagctgggag cggtggctgg tggtgtgcaa gcccttcggc      480

aacgtgcggt tcgacgccaa gctggctatc gtgggaatcg ccttcagctg gatctgggcc      540

gccgtgtgga ccgccccccc tatcttcggc tggagccggt actggcccta cggcctgaag      600

accagctgcg gccccgacgt gttcagcggc agcagctacc ccggcgtgca gagctacatg      660

atcgtgctga tggtgacctg ctgcatcacc cccctgagca tcatcgtgct gtgctacctg      720

caggtgtggc tggccatccg ggccgtggcc aagcagcaga aggagagcga gagcacccag      780

aaggccgaga aggaggtgac ccggatggtg gtggtgatgg tgctggcctt ctgcttctgc      840

tggggcccct acgccttctt cgcctgcttc gccgccgcca accccggcta ccccttccac      900

cccctgatgg ccgccctgcc cagctacttc gccaagagcg ccaccatcta caaccccgtg      960

atctacgtgt tcatgaaccg gcagttccgg aactgcatcc tgcagctgtt cggcaagaag     1020

gtggacgacg gcagcgagct gagcagcgcc agcaagaccg aggtgtcaag cgtgagcagc     1080

gtgagccccg cc                                                         1092


<210>  66
<211>  1047
<212>  DNA
<213>  Homo sapiens

<400>  66
atgagaaaaa tgtcggagga agagttttat ctgttcaaaa atatctcttc agtggggccg       60

tgggatgggc ctcagtacca cattgcccct gtctgggcct tctacctcca ggcagctttc      120

atgggcactg tcttccttat agggttccca ctcaatgcca tggtgctggt ggccacactg      180

cgctacaaaa agttgcggca gcccctcaac tacattctgg tcaacgtgtc cttcggaggc      240

ttcctcctct gcatcttctc tgtcttccct gtcttcgtcg ccagctgtaa cggatacttc      300

gtcttcggtc gccatgtttg tgctttggag ggcttcctgg gcactgtagc aggtctggtt      360

acaggatggt cactggcctt cctggccttt gagcgctaca ttgtcatctg taagcccttc      420

ggcaacttcc gcttcagctc caagcatgca ctgacggtgg tcctggctac ctggaccatt      480

ggtattggcg tctccatccc acccttcttt ggctggagcc ggttcatccc tgagggcctg      540

cagtgttcct gtggccctga ctggtacacc gtgggcacca aataccgcag cgagtcctat      600

acgtggttcc tcttcatctt ctgcttcatt gtgcctctct ccctcatctg cttctcctac      660

actcagctgc tgagggccct gaaagctgtt gcagctcagc agcaggagtc agctacgacc      720

cagaaggctg aacgggaggt gagccgcatg gtggttgtga tggtaggatc cttctgtgtc      780

tgctacgtgc cctacgcggc cttcgccatg tacatggtca acaaccgtaa ccatgggctg      840

gacttacggc ttgtcaccat tccttcattc ttctccaaga gtgcttgcat ctacaatccc      900

atcatctact gcttcatgaa taagcagttc caagcttgca tcatgaagat ggtgtgtggg      960

aaggccatga cagatgaatc cgacacatgc agctcccaga aaacagaagt ttctactgtc     1020

tcgtctaccc aagttggccc caactga                                         1047


<210>  67
<211>  1064
<212>  DNA
<213>  Homo sapiens

<400>  67
acccagtcga gcatcttcac ctataccaac agcaacagta ccagaggtcc ctttgaaggc       60

cccaattatc acattgctcc caggtgggtg taccacctca ccagcgcctg gatgatcttt      120

gtggtcattg catcagtctt cactaatggg cttgtgctgg cagccaccat acggttcaag      180

aagctgcgcc atcctctgaa ttggattctg gtgaacttgg caattgctga cctaatagag      240

accatcattg ctggcactat cagtgttgtg aaccaaatct atggctactt cgtactaggc      300

caccctctgt gcgtcgtgga aggctacatt gtcgccctgt gtggcatcac aggcctctgg      360

tccctggccg ttatttcctg ggagaggtgg ctggtggtct gcaagccctt tggcaatatg      420

agatttgatg ctaagctggc cactgtggga atcatctttt cttgggtctg ggctgctgtg      480

tggacagccc caccaatctt tggttggagc aggtactggc cttatggcct gaagacatcc      540

tgtggtccag acgtgttcag cggcacttcg tatcctgggg ttcagtctta tatgatggtt      600

ctcatggtca cgtgctgcat cttcccactt agcatcatcg tgctctgcta cctccaagtg      660

tggctggcca tccgagcagt agcaaagcaa caaaaagaat ctgagtctac ccagaaggct      720

gagaaggagg tgacacgcat ggtgcttgtg atgatcttcg catactgcat ctgctggggc      780

ccctacgctg tctttgcatg ctttgctact gcccaccctg gctatgcatt ccacccactt      840

gtggcctccc taccatctta ctttgcgaaa agtgccacta tctacaaccc cattatctat      900

gtctttatga accgacagtt tcaaaactgc atcttacagc tctttggaaa gaaggttgat      960

gatagctctg aacttgccag tacctccaaa acagaaacct catctgaagc cgaattccag     1020

cacactggcg gccgtactag tgatccgagt cgtagcctgg accc                      1064


<210>  68
<211>  1041
<212>  DNA
<213>  Homo sapiens

<400>  68
atgtcaggag aggatgactt ttacctgttt cagaatatct cttcggtggg gccctgggat       60

gggcctcagt accaccttgc tcctgtctgg gccttccgcc tccaggcagc cttcatggga      120

tttgtcttct ttgtggggac cccactcaat gccatagtgc tggtggccac actgcattac      180

aaaaagttgc gacagcccct caactatatt ctggtcaatg tatccctcgg gggcttcctc      240

ttctgcatct tctctgtctt cacagtcttc atcgccagct gtcacggata cttcctcttt      300

ggtcgccatg tttgtgctct ggaggccttc ttgggctctg tagcaggtct agtgacagga      360

tggtcattgg ctttcctggc ttttgaacgc tacgttgtca tctgtaaacc cttcggcagc      420

atccgcttca actccaagca tgcactgatg gtggtcctgg ctacttggat tattggtatc      480

ggggtgtcca tcccaccctt ttttggctgg agcaggttca tccctgaggg cctgcagtgc      540

tcctgtggcc cagactggta cactgtgggc accaagtatc gaagcgagta ctacacctgg      600

ttcctcttca tcttctgttt catcattcct ctttccctca tctgcttctc ctactcccag      660

ttgctgagga ctctcagagc tgtggcagct cagcagcaag agtctgctac gacacaaaag      720

gctgaacggg aggtgagtca tatggtggtg gtgatggtgg gatccttctg tctctgctac      780

gtgccctatg ctgccctggc catgtacatg gtcaacaatc ggaaccacgg gctggactta      840

cggcttgtca ccatccccgc cttcttttcc aagagctcct gtgtctacaa ccccatcatc      900

tactgcttca tgaataagca gttccgggct tgcattctgg agatggtgtg caggaagccc      960

atggcagacg aatctgacgt gtctggctct cagaaaacag aagtttctac tgtctcttct     1020

agcaaagttg gccctcactg a                                               1041


<210>  69
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct channel rhodopsin

<400>  69
atggactatg gcggcgcttt gtctgccgtc ggacgcgaac ttttgttcgt tactaatcct       60

gtggtggtga acgggtccgt cctggtccct gaggatcaat gttactgtgc cggatggatt      120

gaatctcgcg gcacgaacgg cgctcagacc gcgtcaaatg tcctgcagtg gcttgcagca      180

ggattcagca ttttgctgct gatgttctat gcctaccaaa cctggaaatc tacatgcggc      240

tgggaggaga tctatgtgtg cgccattgaa atggttaagg tgattctcga gttctttttt      300

gagtttaaga atccctctat gctctacctt gccacaggac accgggtgca gtggctgcgc      360

tatgcagagt ggctgctcac ttgtcctgtc atccttatcc acctgagcaa cctcaccggc      420

ctgagcaacg actacagcag gagaaccatg ggactccttg tctcagacat cgggactatc      480

gtgtgggggg ctaccagcgc catggcaacc ggctatgtta aagtcatctt cttttgtctt      540

ggattgtgct atggcgcgaa cacatttttt cacgccgcca aagcatatat cgagggttat      600

catactgtgc caaagggtcg gtgccgccag gtcgtgaccg gcatggcatg gctgtttttc      660

gtgagctggg gtatgttccc aattctcttc attttggggc ccgaaggttt tggcgtcctg      720

agcgtctatg gctccaccgt aggtcacacg attattgatc tgatgagtaa aaattgttgg      780

gggttgttgg gacactacct gcgcgtcctg atccacgagc acatattgat tcacggagat      840

atccgcaaaa ccaccaaact gaacatcggc ggaacggaga tcgaggtcga gactctcgtc      900

gaagacgaag ccgaggccgg agccgtgcca                                       930


<210>  70
<211>  924
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct halorodopsin

<400>  70
atgaggggta cgcccctgct cctcgtcgtc tctctgttct ctctgcttca ggacacagag       60

accctgcctc ccgtgaccga gagtgccgtg gcccttcaag ccgaggttac ccaaagggag      120

ttgttcgagt tcgtgctgaa cgaccctttg cttgcaagca gtctctatat caacatcgca      180

cttgcaggac tgagtatact gctgttcgtt tttatgaccc gaggactcga tgatccacgg      240

gcaaaactta ttgctgtgtc aaccatcctt gtgcctgtcg tcagcattgc ctcctacact      300

ggattggcga gcggcctgac aatttccgtt cttgaaatgc cagcgggcca ttttgcagaa      360

ggcagctcag tgatgctggg aggagaagag gtagatggtg tagtcaccat gtggggacgg      420

tatctcacct gggcactttc cacgcccatg attctcctcg ctctgggtct cctggccgga      480

agcaatgcta caaagctctt cacagctatc actttcgata tcgctatgtg cgtgactggc      540

cttgccgcgg ccctgactac ctcctcccac ctcatgagat ggttctggta cgctatcagt      600

tgtgcatgct ttctggtggt cttgtatatc ctgctggtgg agtgggcaca ggacgccaaa      660

gccgcgggaa ccgctgacat gttcaatacc ctgaagctgt tgacagtagt gatgtggctg      720

gggtatccaa ttgtgtgggc tcttggagtc gagggtatcg cggtgttgcc cgttggggtg      780

acgagctggg gatattcttt cctggatatc gtggcaaagt acattttcgc attcttgctc      840

ctgaactatc tgacgtcaaa cgaatctgtc gtgtccggca gcattttgga tgttccatct      900

gcttctggga ccccggctga tgat                                             924


<210>  71
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct enhanced green fluorecent protein

<400>  71
atggtgagca agggcgagga gctgttcacc ggggtggtgc ccatcctggt cgagctggac       60

ggcgacgtaa acggccacaa gttcagcgtg tccggcgagg gcgagggcga tgccacctac      120

ggcaagctga ccctgaagtt catctgcacc accggcaagc tgcccgtgcc ctggcccacc      180

ctcgtgacca ccctgaccta cggcgtgcag tgcttcagcc gctaccccga ccacatgaag      240

cagcacgact tcttcaagtc cgccatgccc gaaggctacg tccaggagcg caccatcttc      300

ttcaaggacg acggcaacta caagacccgc gccgaggtga agttcgaggg cgacaccctg      360

gtgaaccgca tcgagctgaa gggcatcgac ttcaaggagg acggcaacat cctggggcac      420

aagctggagt acaactacaa cagccacaac gtctatatca tggccgacaa gcagaagaac      480

ggcatcaagg tgaacttcaa gatccgccac aacatcgagg acggcagcgt gcagctcgcc      540

gaccactacc agcagaacac ccccatcggc gacggccccg tgctgctgcc cgacaaccac      600

tacctgagca cccagtccgc cctgagcaaa gaccccaacg agaagcgcga tcacatggtc      660

ctgctggagt tcgtgaccgc cgccgggatc actctcggca tggacgagct gtacaag         717


<210>  72
<211>  7
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Translation initiation sequence

<400>  72
accatgg                                                                  7


<210>  73
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Translation initiation sequence


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  n is A or G

<400>  73
gccgccncca tgg                                                          13


<210>  74
<211>  221
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct pR2.1 poly A

<400>  74
agacatgata agatacattg atgagtttgg acaaaccaca actagaatgc agtgaaaaaa       60

atgctttatt tgtgaaattt gtgatgctat tgctttattt gtaaccatta taagctgcaa      120

taaacaagtt aacaacaaca attgcattca ttttatgttt caggttcagg gggagatgtg      180

ggaggttttt taaagcaagt aaaacctcta caaatgtggt a                          221


<210>  75
<211>  85
<212>  DNA
<213>  Homo sapiens

<400>  75
tgaggtctgc ctcctaccca tcccgcccac cggggctttg gccacctctc ctttccccct       60

ccttctccat ccctgtaaaa taaat                                             85


<210>  76
<211>  103
<212>  DNA
<213>  Homo sapiens

<400>  76
cccgggtggc atccctgtga cccctcccca gtgcctctcc tggccttgga agttgccact       60

ccagtgccca ccagccttgt cctaataaaa ttaagttgca tca                        103


<210>  77
<211>  225
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct  poly A region

<400>  77
tgtgccttct agttgccagc catctgttgt ttgcccctcc cccgtgcctt ccttgaccct       60

ggaaggtgcc actcccactg tcctttccta ataaaatgag gaaattgcat cgcattgtct      120

gagtaggtgt cattctattc tggggggtgg ggtggggcag gacagcaagg gggaggattg      180

ggaagacaat agcaggcatg ctggggatgc ggtgggctct atggc                      225


<210>  78
<211>  502
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct  poly A region

<400>  78
gtgcaggctg cctatcagaa ggtggtggct ggtgtggcca atgccctggc tcacaaatac       60

cactgagatc tttttccctc tgccaaaaat tatggggaca tcatgaagcc ccttgagcat      120

ctgacttctg gctaataaag gaaatttatt ttcattgcaa tagtgtgttg gaattttttg      180

tgtctctcac tcggaaggac atatgggagg gcaaatcatt taaaacatca gaatgagtat      240

ttggtttaga gtttggcaac atatgccata tgctggctgc catgaacaaa ggtggctata      300

aagaggtcat cagtatatga aacagccccc tgctgtccat tccttattcc atagaaaagc      360

cttgacttga ggttagattt tttttatatt ttgttttgtg ttattttttt ctttaacatc      420

cctaaaattt tccttacatg ttttactagc cagatttttc ctcctctcct gactactccc      480

agtcatagct gtccctcttc tc                                               502


<210>  79
<211>  496
<212>  DNA
<213>  Homo sapiens

<400>  79
ggatccggtt ccaggcctcg gccctaaata gtctccctgg gctttcaaga gaaccacatg       60

agaaaggagg attcgggctc tgagcagttt caccacccac cccccagtct gcaaatcctg      120

acccgtgggt ccacctgccc caaaggcgga cgcaggacag tagaagggaa cagagaacac      180

ataaacacag agagggccac agcggctccc acagtcaccg ccaccttcct ggcggggatg      240

ggtggggcgt ctgagtttgg ttcccagcaa atccctctga gccgcccttg cgggctcgcc      300

tcaggagcag gggagcaaga ggtgggagga ggaggtctaa gtcccaggcc caattaagag      360

atcaggtagt gtagggtttg ggagctttta aggtgaagag gcccgggctg atcccacagg      420

ccagtataaa gcgccgtgac cctcaggtga tgccagggcc ggctgccgtc ggggacaggg      480

ctttccatag ccatgg                                                      496


<210>  80
<211>  149
<212>  DNA
<213>  Homo sapiens

<400>  80
ccagcaaatc cctctgagcc gcccccgggg gctcgcctca ggagcaagga agcaaggggt       60

gggaggagga ggtctaagtc ccaggcccaa ttaagagatc agatggtgta ggatttggga      120

gcttttaagg tgaagaggcc cgggctgat                                        149


<210>  81
<211>  434
<212>  DNA
<213>  Homo sapiens

<400>  81
ggatccggtt ccaggcctcg gccctaaata gtctccctgg gctttcaaga gaaccacatg       60

agaaaggagg attcgggctc tgagcagttt caccacccac cccccagtct gcaaatcctg      120

acccgtgggt ccacctgccc caaaggcgga cgcaggacag tagaagggaa cagagaacac      180

ataaacacag agagggccac agcggctccc acagtcaccg ccaccttcct ggcggggatg      240

ggtggggcgt ctgagtttgg ttcccagcaa atccctctga gccgcccttg cgggctcgcc      300

tcaggagcag gggagcaaga ggtgggagga ggaggtctaa gtcccaggcc caattaagag      360

atcaggtagt gtagggtttg ggagctttta aggtgaagag gcccgggctg atcccacagg      420

ccagtataaa gcgc                                                        434


<210>  82
<211>  263
<212>  DNA
<213>  Homo sapiens

<400>  82
ggatccggtt ccaggcctcg gccctaaata gtctccctgg gctttcaaga gaaccacatg       60

agaaaggagg attcgggctc tgagcagttt caccacccac cccccagtct gcaaatcctg      120

acccgtgggt ccacctgccc caaaggcgga cgcaggacag tagaagggaa cagagaacac      180

ataaacacag agagggccac agcggctccc acagtcaccg ccaccttcct ggcggggatg      240

ggtggggcgt ctgagtttgg ttc                                              263


<210>  83
<211>  171
<212>  DNA
<213>  Homo sapiens

<400>  83
ccagcaaatc cctctgagcc gcccttgcgg gctcgcctca ggagcagggg agcaagaggt       60

gggaggagga ggtctaagtc ccaggcccaa ttaagagatc aggtagtgta gggtttggga      120

gcttttaagg tgaagaggcc cgggctgatc ccacaggcca gtataaagcg c               171


<210>  84
<211>  102
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized 5'UTR

<400>  84
cccactggcc ggtataaagc accgtgaccc tcaggtgacg caccagggcc ggctgccgtc       60

ggggacaggg ctttccatag cccaggccca gagaggagac ag                         102


<210>  85
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized 5'UTR

<400>  85
cccactggcc ggtataaagc accgtgaccc tcaggtgacg caccagggcc ggctgccgtc       60

ggggacaggg ctttccatag cccag                                             85


<210>  86
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized 5'UTR

<400>  86
gcccagagag gagacag                                                      17


<210>  87
<211>  185
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized 5'UTR construct

<400>  87
cgtgaccctc aggtgatgcg ccagggccgg ctgccgtcgg ggacagggct ttccatagcc       60

atgctagagg atccggtact cgaggaactg aaaaaccaga aagttaactg gcctgtacgg      120

aagtgttact tctgctctaa aagctgcgga attgtacccg cggccgcggg acagggcttt      180

ccata                                                                  185


<210>  88
<211>  110
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized 5'UTR construct

<400>  88
cgtgaccctc aggtgatgcg ccagggccgg ctgccgtcgg ggacagggct ttccatagcc       60

atgctagagg atccggtact cgaggaactg aaaaaccaga aagttaactg                 110


<210>  89
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized 5'UTR construct

<400>  89
gcctgtacgg aagtgttact tctgctctaa aagctgcgga attgtacccg cggccgcggg       60

acagggcttt ccata                                                        75


<210>  90
<211>  235
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct  poly A region

<400>  90
ggccgcgggg atccagacat gataagatac attgatgagt ttggacaaac cacaactaga       60

atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc      120

attataagct gcaataaaca agttaacaac aacaattgca ttcattttat gtttcaggtt      180

cagggggaga tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg tggta           235


<210>  91
<211>  152
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct  poly A region

<400>  91
ggccgcgggg atccagacat gataagatac attgatgagt ttggacaaac cacaactaga       60

atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt atttgtaacc      120

attataagct gcaataaaca agttaacaac aa                                    152


<210>  92
<211>  1714
<212>  DNA
<213>  Homo sapiens

<400>  92
cctacagcag ccagggtgag attatgaggc tgagctgaga atatcaagac tgtaccgagt       60

agggggcctt ggcaagtgtg gagagcccgg cagctggggc agagggcgga gtacggtgtg      120

cgtttacgga cctcttcaaa cgaggtagga aggtcagaag tcaaaaaggg aacaaatgat      180

gtttaaccac acaaaaatga aaatccaatg gttggatatc cattccaaat acacaaaggc      240

aacggataag tgatccgggc caggcacaga aggccatgca cccgtaggat tgcactcaga      300

gctcccaaat gcataggaat agaagggtgg gtgcaggagg ctgaggggtg gggaaagggc      360

atgggtgttt catgaggaca gagcttccgt ttcatgcaat gaaaagagtt tggagacgga      420

tggtggtgac tggactatac acttacacac ggtagcgatg gtacactttg tattatgtat      480

attttaccac gatcttttta aagtgtcaaa ggcaaatggc caaatggttc cttgtcctat      540

agctgtagca gccatcggct gttagtgaca aagcccctga gtcaagatga cagcagcccc      600

cataactcct aatcggctct cccgcgtgga gtcatttagg agtagtcgca ttagagacaa      660

gtccaacatc taatcttcca ccctggccag ggccccagct ggcagcgagg gtgggagact      720

ccgggcagag cagagggcgc tgacattggg gcccggcctg gcttgggtcc ctctggcctt      780

tccccagggg ccctctttcc ttggggcttt cttgggccgc cactgctccc gctcctctcc      840

ccccatccca ccccctcacc ccctcgttct tcatatcctt ctctagtgct ccctccactt      900

tcatccaccc ttctgcaaga gtgtgggacc acaaatgagt tttcacctgg cctggggaca      960

cacgtgcccc cacaggtgct gagtgacttt ctaggacagt aatctgcttt aggctaaaat     1020

gggacttgat cttctgttag ccctaatcat caattagcag agccggtgaa ggtgcagaac     1080

ctaccgcctt tccaggcctc ctcccacctc tgccacctcc actctccttc ctgggatgtg     1140

ggggctggca cacgtgtggc ccagggcatt ggtgggattg cactgagctg ggtcattagc     1200

gtaatcctgg acaagggcag acagggcgag cggagggcca gctccggggc tcaggcaagg     1260

ctgggggctt cccccagaca ccccactcct cctctgctgg acccccactt catagggcac     1320

ttcgtgttct caaagggctt ccaaatagca tggtggcctt ggatgcccag ggaagcctca     1380

gagttgctta tctccctcta gacagaaggg gaatctcggt caagagggag aggtcgccct     1440

gttcaaggcc acccagccag ctcatggcgg taatgggaca aggctggcca gccatcccac     1500

cctcagaagg gacccggtgg ggcaggtgat ctcagaggag gctcacttct gggtctcaca     1560

ttcttccagc aaatccctct gagccgcccc cgggggctcg cctcaggagc aaggaagcaa     1620

ggggtgggag gaggaggtct aagtcccagg cccaattaag agatcagatg gtgtaggatt     1680

tgggagcttt taaggtgaag aggcccgggc tgat                                 1714


<210>  93
<211>  234
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized promoter sequence

<400>  93
ccagcaaatc cctctgagcc gcccccgggg gctcgcctca ggagcaagga agcaaggggt       60

gggaggagga ggtctaagtc ccaggcccaa ttaagagatc agatggtgta ggatttggga      120

gcttttaagg tgaagaggcc cgggctgatc ccactggccg gtataaagca ccgtgaccct      180

caggtgacgc accagggccg gctgccgtcg gggacagggc tttccatagc ccag            234


<210>  94
<211>  235
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Optimized intron sequence

<400>  94
cccactggcc ggtataaagc accgtgaccc tcaggtgacg caccagggcc ggctgccgtc       60

ggggacaggg ctttccatag cccaggtaag tatcaaggtt acaagacagg tttaaggaga      120

ccaatagaaa ctgggcttgt cgagacagag aagactcttg cgtttctgat aggcacctat      180

tggtcttact gacatccact ttgcctttct ctccacaggc ccagagagga gacag           235


<210>  95
<211>  1958
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cassette comprising optimized enhance, optimized promoter, 
       optimized 5'UTR, optimized intron, optimized kozak and optimized 
       polyA region

<400>  95
cctacagcag ccagggtgag attatgaggc tgagctgaga atatcaagac tgtaccgagt       60

agggggcctt ggcaagtgtg gagagcccgg cagctggggc agagggcgga gtacggtgtg      120

cgtttacgga cctcttcaaa cgaggtagga aggtcagaag tcaaaaaggg aacaaatgat      180

gtttaaccac acaaaaatga aaatccaatg gttggatatc cattccaaat acacaaaggc      240

aacggataag tgatccgggc caggcacaga aggccatgca cccgtaggat tgcactcaga      300

gctcccaaat gcataggaat agaagggtgg gtgcaggagg ctgaggggtg gggaaagggc      360

atgggtgttt catgaggaca gagcttccgt ttcatgcaat gaaaagagtt tggagacgga      420

tggtggtgac tggactatac acttacacac ggtagcgatg gtacactttg tattatgtat      480

attttaccac gatcttttta aagtgtcaaa ggcaaatggc caaatggttc cttgtcctat      540

agctgtagca gccatcggct gttagtgaca aagcccctga gtcaagatga cagcagcccc      600

cataactcct aatcggctct cccgcgtgga gtcatttagg agtagtcgca ttagagacaa      660

gtccaacatc taatcttcca ccctggccag ggccccagct ggcagcgagg gtgggagact      720

ccgggcagag cagagggcgc tgacattggg gcccggcctg gcttgggtcc ctctggcctt      780

tccccagggg ccctctttcc ttggggcttt cttgggccgc cactgctccc gctcctctcc      840

ccccatccca ccccctcacc ccctcgttct tcatatcctt ctctagtgct ccctccactt      900

tcatccaccc ttctgcaaga gtgtgggacc acaaatgagt tttcacctgg cctggggaca      960

cacgtgcccc cacaggtgct gagtgacttt ctaggacagt aatctgcttt aggctaaaat     1020

gggacttgat cttctgttag ccctaatcat caattagcag agccggtgaa ggtgcagaac     1080

ctaccgcctt tccaggcctc ctcccacctc tgccacctcc actctccttc ctgggatgtg     1140

ggggctggca cacgtgtggc ccagggcatt ggtgggattg cactgagctg ggtcattagc     1200

gtaatcctgg acaagggcag acagggcgag cggagggcca gctccggggc tcaggcaagg     1260

ctgggggctt cccccagaca ccccactcct cctctgctgg acccccactt catagggcac     1320

ttcgtgttct caaagggctt ccaaatagca tggtggcctt ggatgcccag ggaagcctca     1380

gagttgctta tctccctcta gacagaaggg gaatctcggt caagagggag aggtcgccct     1440

gttcaaggcc acccagccag ctcatggcgg taatgggaca aggctggcca gccatcccac     1500

cctcagaagg gacccggtgg ggcaggtgat ctcagaggag gctcacttct gggtctcaca     1560

ttcttccagc aaatccctct gagccgcccc cgggggctcg cctcaggagc aaggaagcaa     1620

ggggtgggag gaggaggtct aagtcccagg cccaattaag agatcagatg gtgtaggatt     1680

tgggagcttt taaggtgaag aggcccgggc tgatcccact ggccggtata aagcaccgtg     1740

accctcaggt gacgcaccag ggccggctgc cgtcggggac agggctttcc atagcccagg     1800

taagtatcaa ggttacaaga caggtttaag gagaccaata gaaactgggc ttgtcgagac     1860

agagaagact cttgcgtttc tgataggcac ctattggtct tactgacatc cactttgcct     1920

ttctctccac aggcccagag aggagacagg ccgccacc                             1958


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide insertion in the AAV GH loop

<400>  96

Leu Gly Glu Thr Thr Arg Pro 
1               5           


<210>  97
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide insertion in the AAV GH loop

<400>  97

Asn Glu Thr Ile Thr Arg Pro 
1               5           


<210>  98
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide insertion in the AAV GH loop

<400>  98

Lys Ala Gly Gln Ala Asn Asn 
1               5           


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide insertion in the AAV GH loop

<400>  99

Lys Asp Pro Lys Thr Thr Asn 
1               5           


<210>  100
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide insertion in the AAV GH loop

<400>  100

Lys Asp Thr Asp Thr Thr Arg 
1               5           


<210>  101
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide insertion in the AAV GH loop

<400>  101

Arg Ala Gly Gly Ser Val Gly 
1               5           


<210>  102
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide insertion in the AAV GH loop

<400>  102

Ala Val Asp Thr Thr Lys Phe 
1               5           


<210>  103
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide insertion in the AAV GH loop

<400>  103

Ser Thr Gly Lys Val Pro Asn 
1               5           


