                         SEQUENCE LISTING

<110>  Sanford Health
       Egland, Kristi
       Evans, Rick
       Pottala, James V.
 
<120>  Reagents and Methods for Breast Cancer Detection

<130>  13-761-PCT

<150>  61/954914
<151>  2014-03-18

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Lys Ser Pro Arg Phe Ala Ser Trp Asp Glu Met Asn Val Leu Ala His 
1               5                   10                  15      


Gly Leu Leu Gln Leu Gly Gln Gly Leu Arg Glu His Ala Glu Arg Thr 
            20                  25                  30          


Arg Ser Gln Leu Ser Ala Leu Glu Arg Arg Leu Ser Ala Cys Gly Ser 
        35                  40                  45              


Ala Cys Gln Gly Thr Glu Gly Ser Thr Asp Leu Pro Leu Ala Pro Glu 
    50                  55                  60                  


Ser Arg Val Asp Pro Glu Val Leu His Ser Leu Gln Thr Gln Leu Lys 
65                  70                  75                  80  


Ala Gln Asn Ser Arg Ile Gln Gln Leu Phe His Lys Val Ala Gln Gln 
                85                  90                  95      


Gln Arg His Leu Glu Lys Gln His Leu Arg Ile Gln His Leu Gln Ser 
            100                 105                 110         


Gln Phe Gly Leu Leu Asp His Lys His Leu Asp His Glu Val Ala Lys 
        115                 120                 125             


Pro Ala Arg Arg Lys Arg Leu Pro Glu Met Ala Gln Pro Val Asp Pro 
    130                 135                 140                 


Ala His Asn Val Ser Arg Leu His Arg Leu Pro Arg Asp Cys Gln Glu 
145                 150                 155                 160 


Leu Phe Gln Val Gly Glu Arg Gln Ser Gly Leu Phe Glu Ile Gln Pro 
                165                 170                 175     


Gln Gly Ser Pro Pro Phe Leu Val Asn Cys Lys Met Thr Ser Asp Gly 
            180                 185                 190         


Gly Trp Thr Val Ile Gln Arg Arg His Asp Gly Ser Val Asp Phe Asn 
        195                 200                 205             


Arg Pro Trp Glu Ala Tyr Lys Ala Gly Phe Gly Asp Pro His Gly Glu 
    210                 215                 220                 


Phe Trp Leu Gly Leu Glu Lys Val His Ser Ile Thr Gly Asp Arg Asn 
225                 230                 235                 240 


Ser Arg Leu Ala Val Gln Leu Arg Asp Trp Asp Gly Asn Ala Glu Leu 
                245                 250                 255     


Leu Gln Phe Ser Val His Leu Gly Gly Glu Asp Thr Ala Tyr Ser Leu 
            260                 265                 270         


Gln Leu Thr Ala Pro Val Ala Gly Gln Leu Gly Ala Thr Thr Val Pro 
        275                 280                 285             


Pro Ser Gly Leu Ser Val Pro Phe Ser Thr Trp Asp Gln Asp His Asp 
    290                 295                 300                 


Leu Arg Arg Asp Lys Asn Cys Ala Lys Ser Leu Ser Gly Gly Trp Trp 
305                 310                 315                 320 


Phe Gly Thr Cys Ser His Ser Asn Leu Asn Gly Gln Tyr Phe Arg Ser 
                325                 330                 335     


Ile Pro Gln Gln Arg Gln Lys Leu Lys Lys Gly Ile Phe Trp Lys Thr 
            340                 345                 350         


Trp Arg Gly Arg Tyr Tyr Pro Leu Gln Ala Thr Thr Met Leu Ile Gln 
        355                 360                 365             


Pro Met Ala Ala Glu Ala Ala Ser 
    370                 375     


<210>  2
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Val Ser Ala Thr Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn 
1               5                   10                  15      


Leu Pro Pro Pro Leu Gly Gly Ala Ala Gly His Pro Gly Ser Ala Val 
            20                  25                  30          


Ser Ala Ala Pro Gly Ile Leu Tyr Pro Gly Gly Asn Lys Tyr Gln Thr 
        35                  40                  45              


Ile Asp Asn Tyr Gln Pro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly 
    50                  55                  60                  


Thr Asp Glu Tyr Cys Ala Ser Pro Thr Arg Gly Gly Asp Ala Gly Val 
65                  70                  75                  80  


Gln Ile Cys Leu Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His 
                85                  90                  95      


Ala Met Cys Cys Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Val Ser 
            100                 105                 110         


Ser Asp Gln Asn His Phe Arg Gly Glu Ile Glu Glu Thr Ile Thr Glu 
        115                 120                 125             


Ser Phe Gly Asn Asp His Ser Thr Leu Asp Gly Tyr Ser Arg Arg Thr 
    130                 135                 140                 


Thr Leu Ser Ser Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val 
145                 150                 155                 160 


Cys Leu Arg Ser Ser Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His 
                165                 170                 175     


Phe Trp Ser Lys Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys 
            180                 185                 190         


Thr Lys His Arg Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg 
        195                 200                 205             


Cys Tyr Cys Gly Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His 
    210                 215                 220                 


Gln Ala Ser Asn Ser Ser Arg Leu His Thr Cys Gln Arg His 
225                 230                 235             


<210>  3
<211>  509
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Lys Glu Val Val Leu Leu Asp Phe Ala Ala Ala Gly Gly Glu Leu Gly 
1               5                   10                  15      


Trp Leu Thr His Pro Tyr Gly Lys Gly Trp Asp Leu Met Gln Asn Ile 
            20                  25                  30          


Met Asn Asp Met Pro Ile Tyr Met Tyr Ser Val Cys Asn Val Met Ser 
        35                  40                  45              


Gly Asp Gln Asp Asn Trp Leu Arg Thr Asn Trp Val Tyr Arg Gly Glu 
    50                  55                  60                  


Ala Glu Arg Ile Phe Ile Glu Leu Lys Phe Thr Val Arg Asp Cys Asn 
65                  70                  75                  80  


Ser Phe Pro Gly Gly Ala Ser Ser Cys Lys Glu Thr Phe Asn Leu Tyr 
                85                  90                  95      


Tyr Ala Glu Ser Asp Leu Asp Tyr Gly Thr Asn Phe Gln Lys Arg Leu 
            100                 105                 110         


Phe Thr Lys Ile Asp Thr Ile Ala Pro Asp Glu Ile Thr Val Ser Ser 
        115                 120                 125             


Asp Phe Glu Ala Arg His Val Lys Leu Asn Val Glu Glu Arg Ser Val 
    130                 135                 140                 


Gly Pro Leu Thr Arg Lys Gly Phe Tyr Leu Ala Phe Gln Asp Ile Gly 
145                 150                 155                 160 


Ala Cys Val Ala Leu Leu Ser Val Arg Val Tyr Tyr Lys Lys Cys Pro 
                165                 170                 175     


Glu Leu Leu Gln Gly Leu Ala His Phe Pro Glu Thr Ile Ala Gly Ser 
            180                 185                 190         


Asp Ala Pro Ser Leu Ala Thr Val Ala Gly Thr Cys Val Asp His Ala 
        195                 200                 205             


Val Val Pro Pro Gly Gly Glu Glu Pro Arg Met His Cys Ala Val Asp 
    210                 215                 220                 


Gly Glu Trp Leu Val Pro Ile Gly Gln Cys Leu Cys Gln Ala Gly Tyr 
225                 230                 235                 240 


Glu Lys Val Glu Asp Ala Cys Gln Ala Cys Ser Pro Gly Phe Phe Lys 
                245                 250                 255     


Phe Glu Ala Ser Glu Ser Pro Cys Leu Glu Cys Pro Glu His Thr Leu 
            260                 265                 270         


Pro Ser Pro Glu Gly Ala Thr Ser Cys Glu Cys Glu Glu Gly Phe Phe 
        275                 280                 285             


Arg Ala Pro Gln Asp Pro Ala Ser Met Pro Cys Thr Arg Pro Pro Ser 
    290                 295                 300                 


Ala Pro His Tyr Leu Thr Ala Val Gly Met Gly Ala Lys Val Glu Leu 
305                 310                 315                 320 


Arg Trp Thr Pro Pro Gln Asp Ser Gly Gly Arg Glu Asp Ile Val Tyr 
                325                 330                 335     


Ser Val Thr Cys Glu Gln Cys Trp Pro Glu Ser Gly Glu Cys Gly Pro 
            340                 345                 350         


Cys Glu Ala Ser Val Arg Tyr Ser Glu Pro Pro His Gly Leu Thr Arg 
        355                 360                 365             


Thr Ser Val Thr Val Ser Asp Leu Glu Pro His Met Asn Tyr Thr Phe 
    370                 375                 380                 


Thr Val Glu Ala Arg Asn Gly Val Ser Gly Leu Val Thr Ser Arg Ser 
385                 390                 395                 400 


Phe Arg Thr Ala Ser Val Ser Ile Asn Gln Thr Glu Pro Pro Lys Val 
                405                 410                 415     


Arg Leu Glu Gly Arg Ser Thr Thr Ser Leu Ser Val Ser Trp Ser Ile 
            420                 425                 430         


Pro Pro Pro Gln Gln Ser Arg Val Trp Lys Tyr Glu Val Thr Tyr Arg 
        435                 440                 445             


Lys Lys Gly Asp Ser Asn Ser Tyr Asn Val Arg Arg Thr Glu Gly Phe 
    450                 455                 460                 


Ser Val Thr Leu Asp Asp Leu Ala Pro Asp Thr Thr Tyr Leu Val Gln 
465                 470                 475                 480 


Val Gln Ala Leu Thr Gln Glu Gly Gln Gly Ala Gly Ser Lys Val His 
                485                 490                 495     


Glu Phe Gln Thr Leu Ser Pro Glu Gly Ser Gly Asn Leu 
            500                 505                 


<210>  4
<211>  1090
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Thr Ser Arg Arg Glu Val Cys Asp Cys Asn Gly Lys Ser Arg Gln Cys 
1               5                   10                  15      


Ile Phe Asp Arg Glu Leu His Arg Gln Thr Gly Asn Gly Phe Arg Cys 
            20                  25                  30          


Leu Asn Cys Asn Asp Asn Thr Asp Gly Ile His Cys Glu Lys Cys Lys 
        35                  40                  45              


Asn Gly Phe Tyr Arg His Arg Glu Arg Asp Arg Cys Leu Pro Cys Asn 
    50                  55                  60                  


Cys Asn Ser Lys Gly Ser Leu Ser Ala Arg Cys Asp Asn Ser Gly Arg 
65                  70                  75                  80  


Cys Ser Cys Lys Pro Gly Val Thr Gly Ala Arg Cys Asp Arg Cys Leu 
                85                  90                  95      


Pro Gly Phe His Met Leu Thr Asp Ala Gly Cys Thr Gln Asp Gln Arg 
            100                 105                 110         


Leu Leu Asp Ser Lys Cys Asp Cys Asp Pro Ala Gly Ile Ala Gly Pro 
        115                 120                 125             


Cys Asp Ala Gly Arg Cys Val Cys Lys Pro Ala Val Thr Gly Glu Arg 
    130                 135                 140                 


Cys Asp Arg Cys Arg Ser Gly Tyr Tyr Asn Leu Asp Gly Gly Asn Pro 
145                 150                 155                 160 


Glu Gly Cys Thr Gln Cys Phe Cys Tyr Gly His Ser Ala Ser Cys Arg 
                165                 170                 175     


Ser Ser Ala Glu Tyr Ser Val His Lys Ile Thr Ser Thr Phe His Gln 
            180                 185                 190         


Asp Val Asp Gly Trp Lys Ala Val Gln Arg Asn Gly Ser Pro Ala Lys 
        195                 200                 205             


Leu Gln Trp Ser Gln Arg His Gln Asp Val Phe Ser Ser Ala Gln Arg 
    210                 215                 220                 


Leu Asp Pro Val Tyr Phe Val Ala Pro Ala Lys Phe Leu Gly Asn Gln 
225                 230                 235                 240 


Gln Val Ser Tyr Gly Gln Ser Leu Ser Phe Asp Tyr Arg Val Asp Arg 
                245                 250                 255     


Gly Gly Arg His Pro Ser Ala His Asp Val Ile Leu Glu Gly Ala Gly 
            260                 265                 270         


Leu Arg Ile Thr Ala Pro Leu Met Pro Leu Gly Lys Thr Leu Pro Cys 
        275                 280                 285             


Gly Leu Thr Lys Thr Tyr Thr Phe Arg Leu Asn Glu His Pro Ser Asn 
    290                 295                 300                 


Asn Trp Ser Pro Gln Leu Ser Tyr Phe Glu Tyr Arg Arg Leu Leu Arg 
305                 310                 315                 320 


Asn Leu Thr Ala Leu Arg Ile Arg Ala Thr Tyr Gly Glu Tyr Ser Thr 
                325                 330                 335     


Gly Tyr Ile Asp Asn Val Thr Leu Ile Ser Ala Arg Pro Val Ser Gly 
            340                 345                 350         


Ala Pro Ala Pro Trp Val Glu Gln Cys Ile Cys Pro Val Gly Tyr Lys 
        355                 360                 365             


Gly Gln Phe Cys Gln Asp Cys Ala Ser Gly Tyr Lys Arg Asp Ser Ala 
    370                 375                 380                 


Arg Leu Gly Pro Phe Gly Thr Cys Ile Pro Cys Asn Cys Gln Gly Gly 
385                 390                 395                 400 


Gly Ala Cys Asp Pro Asp Thr Gly Asp Cys Tyr Ser Gly Asp Glu Asn 
                405                 410                 415     


Pro Asp Ile Glu Cys Ala Asp Cys Pro Ile Gly Phe Tyr Asn Asp Pro 
            420                 425                 430         


His Asp Pro Arg Ser Cys Lys Pro Cys Pro Cys His Asn Gly Phe Ser 
        435                 440                 445             


Cys Ser Val Met Pro Glu Thr Glu Glu Val Val Cys Asn Asn Cys Pro 
    450                 455                 460                 


Pro Gly Val Thr Gly Ala Arg Cys Glu Leu Cys Ala Asp Gly Tyr Phe 
465                 470                 475                 480 


Gly Asp Pro Phe Gly Glu His Gly Pro Val Arg Pro Cys Gln Pro Cys 
                485                 490                 495     


Gln Cys Asn Asn Asn Val Asp Pro Ser Ala Ser Gly Asn Cys Asp Arg 
            500                 505                 510         


Leu Thr Gly Arg Cys Leu Lys Cys Ile His Asn Thr Ala Gly Ile Tyr 
        515                 520                 525             


Cys Asp Gln Cys Lys Ala Gly Tyr Phe Gly Asp Pro Leu Ala Pro Asn 
    530                 535                 540                 


Pro Ala Asp Lys Cys Arg Ala Cys Asn Cys Asn Pro Met Gly Ser Glu 
545                 550                 555                 560 


Pro Val Gly Cys Arg Ser Asp Gly Thr Cys Val Cys Lys Pro Gly Phe 
                565                 570                 575     


Gly Gly Pro Asn Cys Glu His Gly Ala Phe Ser Cys Pro Ala Cys Tyr 
            580                 585                 590         


Asn Gln Val Lys Ile Gln Met Asp Gln Phe Met Gln Gln Leu Gln Arg 
        595                 600                 605             


Met Glu Ala Leu Ile Ser Lys Ala Gln Gly Gly Asp Gly Val Val Pro 
    610                 615                 620                 


Asp Thr Glu Leu Glu Gly Arg Met Gln Gln Ala Glu Gln Ala Leu Gln 
625                 630                 635                 640 


Asp Ile Leu Arg Asp Ala Gln Ile Ser Glu Gly Ala Ser Arg Ser Leu 
                645                 650                 655     


Gly Leu Gln Leu Ala Lys Val Arg Ser Gln Glu Asn Ser Tyr Gln Ser 
            660                 665                 670         


Arg Leu Asp Asp Leu Lys Met Thr Val Glu Arg Val Arg Ala Leu Gly 
        675                 680                 685             


Ser Gln Tyr Gln Asn Arg Val Arg Asp Thr His Arg Leu Ile Thr Gln 
    690                 695                 700                 


Met Gln Leu Ser Leu Ala Glu Ser Glu Ala Ser Leu Gly Asn Thr Asn 
705                 710                 715                 720 


Ile Pro Ala Ser Asp His Tyr Val Gly Pro Asn Gly Phe Lys Ser Leu 
                725                 730                 735     


Ala Gln Glu Ala Thr Arg Leu Ala Glu Ser His Val Glu Ser Ala Ser 
            740                 745                 750         


Asn Met Glu Gln Leu Thr Arg Glu Thr Glu Asp Tyr Ser Lys Gln Ala 
        755                 760                 765             


Leu Ser Leu Val Arg Lys Ala Leu His Glu Gly Val Gly Ser Gly Ser 
    770                 775                 780                 


Gly Ser Pro Asp Gly Ala Val Val Gln Gly Leu Val Glu Lys Leu Glu 
785                 790                 795                 800 


Lys Thr Lys Ser Leu Ala Gln Gln Leu Thr Arg Glu Ala Thr Gln Ala 
                805                 810                 815     


Glu Ile Glu Ala Asp Arg Ser Tyr Gln His Ser Leu Arg Leu Leu Asp 
            820                 825                 830         


Ser Val Ser Arg Leu Gln Gly Val Ser Asp Gln Ser Phe Gln Val Glu 
        835                 840                 845             


Glu Ala Lys Arg Ile Lys Gln Lys Ala Asp Ser Leu Ser Ser Leu Val 
    850                 855                 860                 


Thr Arg His Met Asp Glu Phe Lys Arg Thr Gln Lys Asn Leu Gly Asn 
865                 870                 875                 880 


Trp Lys Glu Glu Ala Gln Gln Leu Leu Gln Asn Gly Lys Ser Gly Arg 
                885                 890                 895     


Glu Lys Ser Asp Gln Leu Leu Ser Arg Ala Asn Leu Ala Lys Ser Arg 
            900                 905                 910         


Ala Gln Glu Ala Leu Ser Met Gly Asn Ala Thr Phe Tyr Glu Val Glu 
        915                 920                 925             


Ser Ile Leu Lys Asn Leu Arg Glu Phe Asp Leu Gln Val Asp Asn Arg 
    930                 935                 940                 


Lys Ala Glu Ala Glu Glu Ala Met Lys Arg Leu Ser Tyr Ile Ser Gln 
945                 950                 955                 960 


Lys Val Ser Asp Ala Ser Asp Lys Thr Gln Gln Ala Glu Arg Ala Leu 
                965                 970                 975     


Gly Ser Ala Ala Ala Asp Ala Gln Arg Ala Lys Asn Gly Ala Gly Glu 
            980                 985                 990         


Ala Leu Glu Ile Ser Ser Glu Ile  Glu Gln Glu Ile Gly  Ser Leu Asn 
        995                 1000                 1005             


Leu Glu  Ala Asn Val Thr Ala  Asp Gly Ala Leu Ala  Met Glu Lys 
    1010                 1015                 1020             


Gly Leu  Ala Ser Leu Lys Ser  Glu Met Arg Glu Val  Glu Gly Glu 
    1025                 1030                 1035             


Leu Glu  Arg Lys Glu Leu Glu  Phe Asp Thr Asn Met  Asp Ala Val 
    1040                 1045                 1050             


Gln Met  Val Ile Thr Glu Ala  Gln Lys Val Asp Thr  Arg Ala Lys 
    1055                 1060                 1065             


Asn Ala  Gly Val Thr Ile Gln  Asp Thr Leu Asn Thr  Leu Asp Gly 
    1070                 1075                 1080             


Leu Leu  His Leu Met Gly Met  
    1085                 1090 


<210>  5
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Gln Pro Leu Gly Gly Glu Ser Ile Cys Ser Ala Arg Ala Pro Ala Lys 
1               5                   10                  15      


Tyr Ser Ile Thr Phe Thr Gly Lys Trp Ser Gln Thr Ala Phe Pro Lys 
            20                  25                  30          


Gln Tyr Pro Leu Phe Arg Pro Pro Ala Gln Trp Ser Ser Leu Leu Gly 
        35                  40                  45              


Ala Ala His Ser Ser Asp Tyr Ser Met Trp Arg Lys Asn Gln Tyr Val 
    50                  55                  60                  


Ser Asn Gly Leu Arg Asp Phe Ala Glu Arg Gly Glu Ala Trp Ala Leu 
65                  70                  75                  80  


Met Lys Glu Ile Glu Ala Ala Gly Glu Ala Leu Gln Ser Val His Glu 
                85                  90                  95      


Val Phe Ser Ala Pro Ala Val Pro Ser Gly Thr Gly Gln Thr Ser Ala 
            100                 105                 110         


Glu Leu Glu Val Gln Arg Arg His Ser Leu Val Ser Phe Val Val Arg 
        115                 120                 125             


Ile Val Pro Ser Pro Asp Trp Phe Val Gly Val Asp Ser Leu Asp Leu 
    130                 135                 140                 


Cys Asp Gly Asp Arg Trp Arg Glu Gln Ala Ala Leu Asp Leu Tyr Pro 
145                 150                 155                 160 


Tyr Asp Ala Gly Thr Asp Ser Gly Phe Thr Phe Ser Ser Pro Asn Phe 
                165                 170                 175     


Ala Thr Ile Pro Gln Asp Thr Val Thr Glu Ile Thr Ser Ser Ser Pro 
            180                 185                 190         


Ser His Pro Ala Asn Ser Phe Tyr Tyr Pro Arg Leu Lys Ala Leu Pro 
        195                 200                 205             


Pro Ile Ala Arg Val Thr Leu Leu Arg Leu Arg Gln Ser Pro Arg Ala 
    210                 215                 220                 


Phe Ile Pro Pro Ala Pro Val Leu Pro Ser Arg Asp Asn Glu Ile Val 
225                 230                 235                 240 


Asp Ser Ala Ser Val Pro Glu Thr Pro Leu Asp Cys Glu Val Ser Leu 
                245                 250                 255     


Trp Ser Ser Trp Gly Leu Cys Gly Gly His Cys Gly Arg Leu Gly Thr 
            260                 265                 270         


Lys Ser Arg Thr Arg Tyr Val Arg Val Gln Pro Ala Asn Asn Gly Ser 
        275                 280                 285             


Pro Cys Pro Glu Leu Glu Glu Glu Ala Glu Cys Val Pro Asp Asn Cys 
    290                 295                 300                 


Val 
305 


<210>  6
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Glu Glu Gly Ala Arg Leu Leu Ala Ser Lys Ser Leu Leu Asn Arg Tyr 
1               5                   10                  15      


Ala Val Glu Gly Arg Asp Leu Thr Leu Gln Tyr Asn Ile Tyr Asn Val 
            20                  25                  30          


Gly Ser Ser Ala Ala Leu Asp Val Glu Leu Ser Asp Asp Ser Phe Pro 
        35                  40                  45              


Pro Glu Asp Phe Gly Ile Val Ser Gly Met Leu Asn Val Lys Trp Asp 
    50                  55                  60                  


Arg Ile Ala Pro Ala Ser Asn Val Ser His Thr Val Val Leu Arg Pro 
65                  70                  75                  80  


Leu Lys Ala Gly Tyr Phe Asn Phe Thr Ser Ala Thr Ile Thr Tyr Leu 
                85                  90                  95      


Ala Gln Glu Asp Gly Pro Val Val Ile Gly Ser Thr Ser Ala Pro Gly 
            100                 105                 110         


Gln Gly Gly Ile Leu Ala Gln Arg Glu Phe Asp Arg Arg Phe Ser Pro 
        115                 120                 125             


His 
    


<210>  7
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Leu Arg Val Arg Gly Glu Val Ala Pro Asp Ala Lys Ser Phe Val Leu 
1               5                   10                  15      


Asn Leu Gly Lys Asp Ser Asn Asn Leu Cys Leu His Phe Asn Pro Arg 
            20                  25                  30          


Phe Asn Ala His Gly Asp Ala Asn Thr Ile Val Cys Asn Ser Lys Asp 
        35                  40                  45              


Gly Gly Ala Trp Gly Thr Glu Gln Arg Glu Ala Val Phe Pro Phe Gln 
    50                  55                  60                  


Pro Gly Ser Val Ala Glu Val Cys Ile Thr Phe Asp Gln Ala Asn Leu 
65                  70                  75                  80  


Thr Val Lys Leu Pro Asp Gly Tyr Glu Phe Lys Phe Pro Asn Arg Leu 
                85                  90                  95      


Asn Leu Glu Ala Ile Asn Tyr Met Ala Ala Asp Gly Asp Phe Lys Ile 
            100                 105                 110         


Lys Cys Val Ala Phe Asp 
        115             


<210>  8
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Asp Arg Leu Asp Cys Val Lys Ala Ser Asp Gln Cys Leu Lys Glu Gln 
1               5                   10                  15      


Ser Cys Ser Thr Lys Tyr Arg Thr Leu Arg Gln Cys Val Ala Gly Lys 
            20                  25                  30          


Glu Thr Asn Phe Ser Leu Ala Ser Gly Leu Glu Ala Lys Asp Glu Cys 
        35                  40                  45              


Arg Ser Ala Met Glu Ala Leu Lys Gln Lys Ser Leu Tyr Asn Cys Arg 
    50                  55                  60                  


Cys Lys Arg Gly Met Lys Lys Glu Lys Asn Cys Leu Arg Ile Tyr Trp 
65                  70                  75                  80  


Ser Met Tyr Gln Ser Leu Gln Gly Asn Asp Leu Leu Glu Asp Ser Pro 
                85                  90                  95      


Tyr Glu Pro Val Asn Ser Arg Leu Ser Asp Ile Phe Arg Val Val Pro 
            100                 105                 110         


Phe Ile Ser Asp Val Phe Gln Gln Val Glu His Ile Pro Lys Gly Asn 
        115                 120                 125             


Asn Cys Leu Asp Ala Ala Lys Ala Cys Asn Leu Asp Asp Ile Cys Lys 
    130                 135                 140                 


Lys Tyr Arg Ser Ala Tyr Ile Thr Pro Cys Thr Thr Ser Val Ser Asn 
145                 150                 155                 160 


Asp Val Cys Asn Arg Arg Lys Cys His Lys Ala Leu Arg Gln Phe Phe 
                165                 170                 175     


Asp Lys Val Pro Ala Lys His Ser Tyr Gly Met Leu Phe Cys Ser Cys 
            180                 185                 190         


Arg Asp Ile Ala Cys Thr Glu Arg Arg Arg Gln Thr Ile Val Pro Val 
        195                 200                 205             


Cys Ser Tyr Glu Glu Arg Glu Lys Pro Asn Cys Leu Asn Leu Gln Asp 
    210                 215                 220                 


Ser Cys Lys Thr Asn Tyr Ile Cys Arg Ser Arg Leu Ala Asp Phe Phe 
225                 230                 235                 240 


Thr Asn Cys Gln Pro Glu Ser Arg Ser Val Ser Ser Cys Leu Lys Glu 
                245                 250                 255     


Asn Tyr Ala Asp Cys Leu Leu Ala Tyr Ser Gly Leu Ile Gly Thr Val 
            260                 265                 270         


Met Thr Pro Asn Tyr Ile Asp Ser Ser Ser Leu Ser Val Ala Pro Trp 
        275                 280                 285             


Cys Asp Cys Ser Asn Ser Gly Asn Asp Leu Glu Glu Cys Leu Lys Phe 
    290                 295                 300                 


Leu Asn Phe Phe Lys Asp Asn Thr Cys Leu Lys Asn Ala Ile Gln Ala 
305                 310                 315                 320 


Phe Gly Asn Gly Ser Asp Val Thr Val Trp Gln Pro Ala Phe Pro Val 
                325                 330                 335     


Gln Thr Thr Thr Ala Thr Thr Thr Thr Ala Leu Arg Val Lys Asn Lys 
            340                 345                 350         


Pro Leu Gly Pro Ala Gly Ser Glu Asn Glu Ile Pro Thr His Val Leu 
        355                 360                 365             


Pro Pro Cys Ala Asn Leu Gln Ala Gln Lys Leu Lys Ser Asn Val Ser 
    370                 375                 380                 


Gly Asn Thr His Leu Cys Ile Ser Asn Gly Asn Tyr Glu Lys Glu Gly 
385                 390                 395                 400 


Leu Gly Ala Ser Ser His Ile Thr Thr Lys Ser Met Ala Ala Pro Pro 
                405                 410                 415     


Ser Cys Gly Leu Ser Pro Leu Leu Val Leu Val Val Thr Ala Leu Ser 
            420                 425                 430         


Thr Leu Leu Ser Leu Thr Glu Thr Ser 
        435                 440     


<210>  9
<211>  517
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Tyr His Gly Cys Pro Ser Glu Cys Thr Cys Ser Arg Ala Ser Gln Val 
1               5                   10                  15      


Glu Cys Thr Gly Ala Arg Ile Val Ala Val Pro Thr Pro Leu Pro Trp 
            20                  25                  30          


Asn Ala Met Ser Leu Gln Ile Leu Asn Thr His Ile Thr Glu Leu Asn 
        35                  40                  45              


Glu Ser Pro Phe Leu Asn Ile Ser Ala Leu Ile Ala Leu Arg Ile Glu 
    50                  55                  60                  


Lys Asn Glu Leu Ser Arg Ile Thr Pro Gly Ala Phe Arg Asn Leu Gly 
65                  70                  75                  80  


Ser Leu Arg Tyr Leu Ser Leu Ala Asn Asn Lys Leu Gln Val Leu Pro 
                85                  90                  95      


Ile Gly Leu Phe Gln Gly Leu Asp Ser Leu Glu Ser Leu Leu Leu Ser 
            100                 105                 110         


Ser Asn Gln Leu Leu Gln Ile Gln Pro Ala His Phe Ser Gln Cys Ser 
        115                 120                 125             


Asn Leu Lys Glu Leu Gln Leu His Gly Asn His Leu Glu Tyr Ile Pro 
    130                 135                 140                 


Asp Gly Ala Phe Asp His Leu Val Gly Leu Thr Lys Leu Asn Leu Gly 
145                 150                 155                 160 


Lys Asn Ser Leu Thr His Ile Ser Pro Arg Val Phe Gln His Leu Gly 
                165                 170                 175     


Asn Leu Gln Val Leu Arg Leu Tyr Glu Asn Arg Leu Thr Asp Ile Pro 
            180                 185                 190         


Met Gly Thr Phe Asp Gly Leu Val Asn Leu Gln Glu Leu Ala Leu Gln 
        195                 200                 205             


Gln Asn Gln Ile Gly Leu Leu Ser Pro Gly Leu Phe His Asn Asn His 
    210                 215                 220                 


Asn Leu Gln Arg Leu Tyr Leu Ser Asn Asn His Ile Ser Gln Leu Pro 
225                 230                 235                 240 


Pro Ser Val Phe Met Gln Leu Pro Gln Leu Asn Arg Leu Thr Leu Phe 
                245                 250                 255     


Gly Asn Ser Leu Lys Glu Leu Ser Pro Gly Ile Phe Gly Pro Met Pro 
            260                 265                 270         


Asn Leu Arg Glu Leu Trp Leu Tyr Asp Asn His Ile Ser Ser Leu Pro 
        275                 280                 285             


Asp Asn Val Phe Ser Asn Leu Arg Gln Leu Gln Val Leu Ile Leu Ser 
    290                 295                 300                 


Arg Asn Gln Ile Ser Phe Ile Ser Pro Gly Ala Phe Asn Gly Leu Thr 
305                 310                 315                 320 


Glu Leu Arg Glu Leu Ser Leu His Thr Asn Ala Leu Gln Asp Leu Asp 
                325                 330                 335     


Gly Asn Val Phe Arg Met Leu Ala Asn Leu Gln Asn Ile Ser Leu Gln 
            340                 345                 350         


Asn Asn Arg Leu Arg Gln Leu Pro Gly Asn Ile Phe Ala Asn Val Asn 
        355                 360                 365             


Gly Leu Met Ala Ile Gln Leu Gln Asn Asn Gln Leu Glu Asn Leu Pro 
    370                 375                 380                 


Leu Gly Ile Phe Asp His Leu Gly Lys Leu Cys Glu Leu Arg Leu Tyr 
385                 390                 395                 400 


Asp Asn Pro Trp Arg Cys Asp Ser Asp Ile Leu Pro Leu Arg Asn Trp 
                405                 410                 415     


Leu Leu Leu Asn Gln Pro Arg Leu Gly Thr Asp Thr Val Pro Val Cys 
            420                 425                 430         


Phe Ser Pro Ala Asn Val Arg Gly Gln Ser Leu Ile Ile Ile Asn Val 
        435                 440                 445             


Asn Val Ala Val Pro Ser Val His Val Pro Glu Val Pro Ser Tyr Pro 
    450                 455                 460                 


Glu Thr Pro Trp Tyr Pro Asp Thr Pro Ser Tyr Pro Asp Thr Thr Ser 
465                 470                 475                 480 


Val Ser Ser Thr Thr Glu Leu Thr Ser Pro Val Glu Asp Tyr Thr Asp 
                485                 490                 495     


Leu Thr Thr Ile Gln Val Thr Asp Asp Arg Ser Val Trp Gly Met Thr 
            500                 505                 510         


Gln Ala Gln Ser Gly 
        515         


<210>  10
<211>  576
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Thr Arg Cys Pro Asp Gly Gln Phe Cys Pro Val Ala Cys Cys Leu Asp 
1               5                   10                  15      


Pro Gly Gly Ala Ser Tyr Ser Cys Cys Arg Pro Leu Leu Asp Lys Trp 
            20                  25                  30          


Pro Thr Thr Leu Ser Arg His Leu Gly Gly Pro Cys Gln Val Asp Ala 
        35                  40                  45              


His Cys Ser Ala Gly His Ser Cys Ile Phe Thr Val Ser Gly Thr Ser 
    50                  55                  60                  


Ser Cys Cys Pro Phe Pro Glu Ala Val Ala Cys Gly Asp Gly His His 
65                  70                  75                  80  


Cys Cys Pro Arg Gly Phe His Cys Ser Ala Asp Gly Arg Ser Cys Phe 
                85                  90                  95      


Gln Arg Ser Gly Asn Asn Ser Val Gly Ala Ile Gln Cys Pro Asp Ser 
            100                 105                 110         


Gln Phe Glu Cys Pro Asp Phe Ser Thr Cys Cys Val Met Val Asp Gly 
        115                 120                 125             


Ser Trp Gly Cys Cys Pro Met Pro Gln Ala Ser Cys Cys Glu Asp Arg 
    130                 135                 140                 


Val His Cys Cys Pro His Gly Ala Phe Cys Asp Leu Val His Thr Arg 
145                 150                 155                 160 


Cys Ile Thr Pro Thr Gly Thr His Pro Leu Ala Lys Lys Leu Pro Ala 
                165                 170                 175     


Gln Arg Thr Asn Arg Ala Val Ala Leu Ser Ser Ser Val Met Cys Pro 
            180                 185                 190         


Asp Ala Arg Ser Arg Cys Pro Asp Gly Ser Thr Cys Cys Glu Leu Pro 
        195                 200                 205             


Ser Gly Lys Tyr Gly Cys Cys Pro Met Pro Asn Ala Thr Cys Cys Ser 
    210                 215                 220                 


Asp His Leu His Cys Cys Pro Gln Asp Thr Val Cys Asp Leu Ile Gln 
225                 230                 235                 240 


Ser Lys Cys Leu Ser Lys Glu Asn Ala Thr Thr Asp Leu Leu Thr Lys 
                245                 250                 255     


Leu Pro Ala His Thr Val Gly Asp Val Lys Cys Asp Met Glu Val Ser 
            260                 265                 270         


Cys Pro Asp Gly Tyr Thr Cys Cys Arg Leu Gln Ser Gly Ala Trp Gly 
        275                 280                 285             


Cys Cys Pro Phe Thr Gln Ala Val Cys Cys Glu Asp His Ile His Cys 
    290                 295                 300                 


Cys Pro Ala Gly Phe Thr Cys Asp Thr Gln Lys Gly Thr Cys Glu Gln 
305                 310                 315                 320 


Gly Pro His Gln Val Pro Trp Met Glu Lys Ala Pro Ala His Leu Ser 
                325                 330                 335     


Leu Pro Asp Pro Gln Ala Leu Lys Arg Asp Val Pro Cys Asp Asn Val 
            340                 345                 350         


Ser Ser Cys Pro Ser Ser Asp Thr Cys Cys Gln Leu Thr Ser Gly Glu 
        355                 360                 365             


Trp Gly Cys Cys Pro Ile Pro Glu Ala Val Cys Cys Ser Asp His Gln 
    370                 375                 380                 


His Cys Cys Pro Gln Gly Tyr Thr Cys Val Ala Glu Gly Gln Cys Gln 
385                 390                 395                 400 


Arg Gly Ser Glu Ile Val Ala Gly Leu Glu Lys Met Pro Ala Arg Arg 
                405                 410                 415     


Ala Ser Leu Ser His Pro Arg Asp Ile Gly Cys Asp Gln His Thr Ser 
            420                 425                 430         


Cys Pro Val Gly Gln Thr Cys Cys Pro Ser Leu Gly Gly Ser Trp Ala 
        435                 440                 445             


Cys Cys Gln Leu Pro His Ala Val Cys Cys Glu Asp Arg Gln His Cys 
    450                 455                 460                 


Cys Pro Ala Gly Tyr Thr Cys Asn Val Lys Ala Arg Ser Cys Glu Lys 
465                 470                 475                 480 


Glu Val Val Ser Ala Gln Pro Ala Thr Phe Leu Ala Arg Ser Pro His 
                485                 490                 495     


Val Gly Val Lys Asp Val Glu Cys Gly Glu Gly His Phe Cys His Asp 
            500                 505                 510         


Asn Gln Thr Cys Cys Arg Asp Asn Arg Gln Gly Trp Ala Cys Cys Pro 
        515                 520                 525             


Tyr Arg Gln Gly Val Cys Cys Ala Asp Arg Arg His Cys Cys Pro Ala 
    530                 535                 540                 


Gly Phe Arg Cys Ala Ala Arg Gly Thr Lys Cys Leu Arg Arg Glu Ala 
545                 550                 555                 560 


Pro Arg Trp Asp Ala Pro Leu Arg Asp Pro Ala Leu Arg Gln Leu Leu 
                565                 570                 575     


<210>  11
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Ala Pro Lys Pro Ala Thr Val Val Thr Gly Ser Gly His Ala Ser Ser 
1               5                   10                  15      


Thr Pro Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val 
            20                  25                  30          


Pro Ser Ser Thr Glu Lys Asn Ala Phe Asn Ser Ser Leu Glu Asp Pro 
        35                  40                  45              


Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe 
    50                  55                  60                  


Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys 
65                  70                  75                  80  


Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu 
                85                  90                  95      


Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
            100                 105                 110         


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
        115                 120                 125             


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro 
    130                 135                 140                 


Gly 
145 


<210>  12
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Ala Ala Gly Thr Val Phe Thr Thr Val Glu Asp Leu Gly Ser Lys Ile 
1               5                   10                  15      


Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala Thr Glu Val Thr Gly His 
            20                  25                  30          


Arg Trp Leu Lys Gly Gly Val Val Leu Lys Glu Asp Ala Leu Pro Gly 
        35                  40                  45              


Gln Lys Thr Glu Phe Lys Val Asp Ser Asp Asp Gln Trp Gly Glu Tyr 
    50                  55                  60                  


Ser Cys Val Phe Leu Pro Glu Pro Met Gly Thr Ala Asn Ile Gln Leu 
65                  70                  75                  80  


His Gly Pro Pro Arg Val Lys Ala Val Lys Ser Ser Glu His Ile Asn 
                85                  90                  95      


Glu Gly Glu Thr Ala Met Leu Val Cys Lys Ser Glu Ser Val Pro Pro 
            100                 105                 110         


Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr Asp Ser Glu Asp Lys Ala 
        115                 120                 125             


Leu Met Asn Gly Ser Glu Ser Arg Phe Phe Val Ser Ser 
    130                 135                 140     


<210>  13
<211>  184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Ala Gly Pro Ser Ser Gly Ser Cys Pro Pro Thr Lys Phe Gln Cys Arg 
1               5                   10                  15      


Thr Ser Gly Leu Cys Val Pro Leu Thr Trp Arg Cys Asp Arg Asp Leu 
            20                  25                  30          


Asp Cys Ser Asp Gly Ser Asp Glu Glu Glu Cys Arg Ile Glu Pro Cys 
        35                  40                  45              


Thr Gln Lys Gly Gln Cys Pro Pro Pro Pro Gly Leu Pro Cys Pro Cys 
    50                  55                  60                  


Thr Gly Val Ser Asp Cys Ser Gly Gly Thr Asp Lys Lys Leu Arg Asn 
65                  70                  75                  80  


Cys Ser Arg Leu Ala Cys Leu Ala Gly Glu Leu Arg Cys Thr Leu Ser 
                85                  90                  95      


Asp Asp Cys Ile Pro Leu Thr Trp Arg Cys Asp Gly His Pro Asp Cys 
            100                 105                 110         


Pro Asp Ser Ser Asp Glu Leu Gly Cys Gly Thr Asn Glu Ile Leu Pro 
        115                 120                 125             


Glu Gly Asp Ala Thr Thr Met Gly Pro Pro Val Thr Leu Glu Ser Val 
    130                 135                 140                 


Thr Ser Leu Arg Asn Ala Thr Thr Met Gly Pro Pro Val Thr Leu Glu 
145                 150                 155                 160 


Ser Val Pro Ser Val Gly Asn Ala Thr Ser Ser Ser Ala Gly Asp Gln 
                165                 170                 175     


Ser Gly Ser Pro Thr Ala Tyr Gly 
            180                 


<210>  14
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Glu Pro Cys Arg Ala Val Phe Arg Glu Ala Glu Val Thr Leu Glu Ala 
1               5                   10                  15      


Gly Gly Ala Glu Gln Glu Pro Gly Gln Ala Leu Gly Lys Val Phe Met 
            20                  25                  30          


Gly Cys Pro Gly Gln Glu Pro Ala Leu Phe Ser Thr Asp Asn Asp Asp 
        35                  40                  45              


Phe Thr Val Arg Asn Gly Glu Thr Val Gln Glu Arg Arg Ser Leu Lys 
    50                  55                  60                  


Glu Arg Asn Pro Leu Lys Ile Phe Pro Ser Lys Arg Ile Leu Arg Arg 
65                  70                  75                  80  


His Lys Arg Asp Trp Val Val Ala Pro Ile Ser Val Pro Glu Asn Gly 
                85                  90                  95      


Lys Gly Pro Phe Pro Gln Arg Leu Asn Gln Leu Lys Ser Asn Lys Asp 
            100                 105                 110         


Arg Asp Thr Lys Ile Phe Tyr Ser Ile Thr Gly Pro Gly Ala Asp Ser 
        115                 120                 125             


Pro Pro Glu Gly Val Phe Ala Val Glu Lys Glu Thr Gly Trp Leu Leu 
    130                 135                 140                 


Leu Asn Lys Pro Leu Asp Arg Glu Glu Ile Ala Lys Tyr Glu Leu Phe 
145                 150                 155                 160 


Gly His Ala Val Ser Glu Asn Gly Ala Ser Val Glu Asp Pro Met Asn 
                165                 170                 175     


Ile Ser Ile Ile Val Thr Asp Gln Asn Asp His Lys Pro Lys Phe Thr 
            180                 185                 190         


Gln Asp Thr Phe Arg Gly Ser Val Leu Glu Gly Val Leu Pro Gly Thr 
        195                 200                 205             


Ser Val Met Gln Met Thr Ala Thr Asp Glu Asp Asp Ala Ile Tyr Thr 
    210                 215                 220                 


Tyr Asn Gly Val Val Ala Tyr Ser Ile His Ser Gln Glu Pro Lys Asp 
225                 230                 235                 240 


Pro His Asp Leu Met Phe Thr Ile His Arg Ser Thr Gly Thr Ile Ser 
                245                 250                 255     


Val Ile Ser Ser Gly Leu Asp Arg Glu Lys Val Pro Glu Tyr Thr Leu 
            260                 265                 270         


Thr Ile Gln Ala Thr Asp Met Asp Gly Asp Gly Ser Thr Thr Thr Ala 
        275                 280                 285             


Val Ala Val Val Glu Ile Leu Asp Ala Asn Asp Asn Ala Pro Met Phe 
    290                 295                 300                 


Asp Pro Gln Lys Tyr Glu Ala His Val Pro Glu Asn Ala Val Gly His 
305                 310                 315                 320 


Glu Val Gln Arg Leu Thr Val Thr Asp Leu Asp Ala Pro Asn Ser Pro 
                325                 330                 335     


Ala Trp Arg Ala Thr Tyr Leu Ile Met Gly Gly Asp Asp Gly Asp His 
            340                 345                 350         


Phe Thr Ile Thr Thr His Pro Glu Ser Asn Gln Gly Ile Leu Thr Thr 
        355                 360                 365             


Arg Lys Gly Leu Asp Phe Glu Ala Lys Asn Gln His Thr Leu Tyr Val 
    370                 375                 380                 


Glu Val Thr Asn Glu Ala Pro Phe Val Leu Lys Leu Pro Thr Ser Thr 
385                 390                 395                 400 


Ala Thr Ile Val Val His Val Glu Asp Val Asn Glu Ala Pro Val Phe 
                405                 410                 415     


Val Pro Pro Ser Lys Val Val Glu Val Gln Glu Gly Ile Pro Thr Gly 
            420                 425                 430         


Glu Pro Val Cys Val Tyr Thr Ala Glu Asp Pro Asp Lys Glu Asn Gln 
        435                 440                 445             


Lys Ile Ser Tyr Arg Ile Leu Arg Asp Pro Ala Gly Trp Leu Ala Met 
    450                 455                 460                 


Asp Pro Asp Ser Gly Gln Val Thr Ala Val Gly Thr Leu Asp Arg Glu 
465                 470                 475                 480 


Asp Glu Gln Phe Val Arg Asn Asn Ile Tyr Glu Val Met Val Leu Ala 
                485                 490                 495     


Met Asp Asn Gly Ser Pro Pro Thr Thr Gly Thr Gly Thr Leu Leu Leu 
            500                 505                 510         


Thr Leu Ile Asp Val Asn Asp His Gly Pro Val Pro Glu Pro Arg Gln 
        515                 520                 525             


Ile Thr Ile Cys Asn Gln Ser Pro Val Arg Gln Val Leu Asn Ile Thr 
    530                 535                 540                 


Asp Lys Asp Leu Ser Pro His Thr Ser Pro Phe Gln Ala Gln Leu Thr 
545                 550                 555                 560 


Asp Asp Ser Asp Ile Tyr Trp Thr Ala Glu Val Asn Glu Glu Gly Asp 
                565                 570                 575     


Thr Val Val Leu Ser Leu Lys Lys Phe Leu Lys Gln Asp Thr Tyr Asp 
            580                 585                 590         


Val His Leu Ser Leu Ser Asp His Gly Asn Lys Glu Gln Leu Thr Val 
        595                 600                 605             


Ile Arg Ala Thr Val Cys Asp Cys His Gly His Val Glu Thr Cys Pro 
    610                 615                 620                 


Gly Pro Trp Lys Gly Gly 
625                 630 


<210>  15
<211>  630
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Thr Gln Val Cys Thr Gly Thr Asp Met Lys Leu Arg Leu Pro Ala Ser 
1               5                   10                  15      


Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln Gly Cys Gln 
            20                  25                  30          


Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr Asn Ala Ser 
        35                  40                  45              


Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr Val Leu Ile 
    50                  55                  60                  


Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu Arg Ile Val 
65                  70                  75                  80  


Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala Val Leu Asp 
                85                  90                  95      


Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly Ala Ser Pro 
            100                 105                 110         


Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu Ile Leu Lys 
        115                 120                 125             


Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr Gln Asp Thr 
    130                 135                 140                 


Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu Ala Leu Thr 
145                 150                 155                 160 


Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys Ser Pro Met 
                165                 170                 175     


Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp Cys Gln Ser 
            180                 185                 190         


Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys Lys Gly Pro 
        195                 200                 205             


Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly Cys Thr Gly 
    210                 215                 220                 


Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn His Ser Gly 
225                 230                 235                 240 


Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn Thr Asp Thr 
                245                 250                 255     


Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe Gly Ala Ser 
            260                 265                 270         


Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp Val Gly Ser 
        275                 280                 285             


Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr Ala Glu Asp 
    290                 295                 300                 


Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala Arg Val Cys 
305                 310                 315                 320 


Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala Val Thr Ser 
                325                 330                 335     


Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe Gly Ser Leu 
            340                 345                 350         


Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser Asn Thr Ala 
        355                 360                 365             


Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu Glu Glu Ile 
    370                 375                 380                 


Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu Pro Asp Leu 
385                 390                 395                 400 


Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile Leu His Asn 
                405                 410                 415     


Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser Trp Leu Gly 
            420                 425                 430         


Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu Ile His His 
        435                 440                 445             


Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp Gln Leu Phe 
    450                 455                 460                 


Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg Pro Glu Asp 
465                 470                 475                 480 


Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys Ala Arg Gly 
                485                 490                 495     


His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys Ser Gln Phe 
            500                 505                 510         


Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu Gln Gly Leu 
        515                 520                 525             


Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys His Pro Glu 
    530                 535                 540                 


Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro Glu Ala Asp 
545                 550                 555                 560 


Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe Cys Val Ala 
                565                 570                 575     


Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met Pro Ile Trp 
            580                 585                 590         


Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro Ile Asn Cys 
        595                 600                 605             


Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro Ala Glu Gln 
    610                 615                 620                 


Arg Ala Ser Pro Leu Thr 
625                 630 


<210>  16
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Glu Val Leu Phe Arg Cys Pro Pro Cys Thr Pro Glu Arg Leu Ala Ala 
1               5                   10                  15      


Cys Gly Pro Pro Pro Val Ala Pro Pro Ala Ala Val Ala Ala Val Ala 
            20                  25                  30          


Gly Gly Ala Arg Met Pro Cys Ala Glu Leu Val Arg Glu Pro Gly Cys 
        35                  40                  45              


Gly Cys Cys Ser Val Cys Ala Arg Leu Glu Gly Glu Ala Cys Gly Val 
    50                  55                  60                  


Tyr Thr Pro Arg Cys Gly Gln Gly Leu Arg Cys Tyr Pro His Pro Gly 
65                  70                  75                  80  


Ser Glu Leu Pro Leu Gln Ala Leu Val Met Gly Glu Gly Thr Cys Glu 
                85                  90                  95      


Lys Arg Arg Asp Ala Glu Tyr Gly Ala Ser Pro Glu Gln Val Ala Asp 
            100                 105                 110         


Asn Gly Asp Asp His Ser Glu Gly Gly Leu Val Glu Asn His Val Asp 
        115                 120                 125             


Ser Thr Met Asn Met Leu Gly Gly Gly Gly Ser Ala Gly Arg Lys Pro 
    130                 135                 140                 


Leu Lys Ser Gly Met Lys Glu Leu Ala Val Phe Arg Glu Lys Val Thr 
145                 150                 155                 160 


Glu Gln His Arg Gln Met Gly Lys Gly Gly Lys His His Leu Gly Leu 
                165                 170                 175     


Glu Glu Pro Lys Lys Leu Arg Pro Pro Pro Ala Arg Thr Pro Cys Gln 
            180                 185                 190         


Gln Glu Leu Asp Gln Val Leu Glu Arg Ile Ser Thr Met Arg Leu Pro 
        195                 200                 205             


Asp Glu Arg Gly Pro Leu Glu His Leu Tyr Ser Leu His Ile Pro Asn 
    210                 215                 220                 


Cys Asp Lys His Gly Leu Tyr Asn Leu Lys Gln Cys Lys Met Ser Leu 
225                 230                 235                 240 


Asn Gly Gln Arg Gly Glu Cys Trp Cys Val Asn Pro Asn Thr Gly Lys 
                245                 250                 255     


Leu Ile Gln Gly Ala Pro Thr Ile Arg Gly Asp Pro Glu Cys His Leu 
            260                 265                 270         


Phe Tyr Asn Glu Gln Gln Glu Ala Arg Gly Val His Thr Gln Arg Met 
        275                 280                 285             


Gln 
    


<210>  17
<211>  424
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

His Pro Asp Arg Ile Ile Phe Pro Asn His Ala Cys Glu Asp Pro Pro 
1               5                   10                  15      


Ala Val Leu Leu Glu Val Gln Gly Thr Leu Gln Arg Pro Leu Val Arg 
            20                  25                  30          


Asp Ser Arg Thr Ser Pro Ala Asn Cys Thr Trp Leu Ile Leu Gly Ser 
        35                  40                  45              


Lys Glu Gln Thr Val Thr Ile Arg Phe Gln Lys Leu His Leu Ala Cys 
    50                  55                  60                  


Gly Ser Glu Arg Leu Thr Leu Arg Ser Pro Leu Gln Pro Leu Ile Ser 
65                  70                  75                  80  


Leu Cys Glu Ala Pro Pro Ser Pro Leu Gln Leu Pro Gly Gly Asn Val 
                85                  90                  95      


Thr Ile Thr Tyr Ser Tyr Ala Gly Ala Arg Ala Pro Met Gly Gln Gly 
            100                 105                 110         


Phe Leu Leu Ser Tyr Ser Gln Asp Trp Leu Met Cys Leu Gln Glu Glu 
        115                 120                 125             


Phe Gln Cys Leu Asn His Arg Cys Val Ser Ala Val Gln Arg Cys Asp 
    130                 135                 140                 


Gly Val Asp Ala Cys Gly Asp Gly Ser Asp Glu Ala Gly Cys Ser Ser 
145                 150                 155                 160 


Asp Pro Phe Pro Gly Leu Thr Pro Arg Pro Val Pro Ser Leu Pro Cys 
                165                 170                 175     


Asn Val Thr Leu Glu Asp Phe Tyr Gly Val Phe Ser Ser Pro Gly Tyr 
            180                 185                 190         


Thr His Leu Ala Ser Val Ser His Pro Gln Ser Cys His Trp Leu Leu 
        195                 200                 205             


Asp Pro His Asp Gly Arg Arg Leu Ala Val Arg Phe Thr Ala Leu Asp 
    210                 215                 220                 


Leu Gly Phe Gly Asp Ala Val His Val Tyr Asp Gly Pro Gly Pro Pro 
225                 230                 235                 240 


Glu Ser Ser Arg Leu Leu Arg Ser Leu Thr His Phe Ser Asn Gly Lys 
                245                 250                 255     


Ala Val Thr Val Glu Thr Leu Ser Gly Gln Ala Val Val Ser Tyr His 
            260                 265                 270         


Thr Val Ala Trp Ser Asn Gly Arg Gly Phe Asn Ala Thr Tyr His Val 
        275                 280                 285             


Arg Gly Tyr Cys Leu Pro Trp Asp Arg Pro Cys Gly Leu Gly Ser Gly 
    290                 295                 300                 


Leu Gly Ala Gly Glu Gly Leu Gly Glu Arg Cys Tyr Ser Glu Ala Gln 
305                 310                 315                 320 


Arg Cys Asp Gly Ser Trp Asp Cys Ala Asp Gly Thr Asp Glu Glu Asp 
                325                 330                 335     


Cys Pro Gly Cys Pro Pro Gly His Phe Pro Cys Gly Ala Ala Gly Thr 
            340                 345                 350         


Ser Gly Ala Thr Ala Cys Tyr Leu Pro Ala Asp Arg Cys Asn Tyr Gln 
        355                 360                 365             


Thr Phe Cys Ala Asp Gly Ala Asp Glu Arg Arg Cys Arg His Cys Gln 
    370                 375                 380                 


Pro Gly Asn Phe Arg Cys Arg Asp Glu Lys Cys Val Tyr Glu Thr Trp 
385                 390                 395                 400 


Val Cys Asp Gly Gln Pro Asp Cys Ala Asp Gly Ser Asp Glu Trp Asp 
                405                 410                 415     


Cys Ser Tyr Val Leu Pro Arg Lys 
            420                 


<210>  18
<211>  171
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Ala Asp Arg Glu Arg Ser Ile His Asp Phe Cys Leu Val Ser Lys Val 
1               5                   10                  15      


Val Gly Arg Cys Arg Ala Ser Met Pro Arg Trp Trp Tyr Asn Val Thr 
            20                  25                  30          


Asp Gly Ser Cys Gln Leu Phe Val Tyr Gly Gly Cys Asp Gly Asn Ser 
        35                  40                  45              


Asn Asn Tyr Leu Thr Lys Glu Glu Cys Leu Lys Lys Cys Ala Thr Val 
    50                  55                  60                  


Thr Glu Asn Ala Thr Gly Asp Leu Ala Thr Ser Arg Asn Ala Ala Asp 
65                  70                  75                  80  


Ser Ser Val Pro Ser Ala Pro Arg Arg Gln Asp Ser Glu Asp His Ser 
                85                  90                  95      


Ser Asp Met Phe Asn Tyr Glu Glu Tyr Cys Thr Ala Asn Ala Val Thr 
            100                 105                 110         


Gly Pro Cys Arg Ala Ser Phe Pro Arg Trp Tyr Phe Asp Val Glu Arg 
        115                 120                 125             


Asn Ser Cys Asn Asn Phe Ile Tyr Gly Gly Cys Arg Gly Asn Lys Asn 
    130                 135                 140                 


Ser Tyr Arg Ser Glu Glu Ala Cys Met Leu Arg Cys Phe Arg Gln Gln 
145                 150                 155                 160 


Glu Asn Pro Pro Leu Pro Leu Gly Ser Lys Val 
                165                 170     


<210>  19
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Gln Glu Ser Cys Ser Met Arg Cys Gly Ala Leu Asp Gly Pro Cys Ser 
1               5                   10                  15      


Cys His Pro Thr Cys Ser Gly Leu Gly Thr Cys Cys Leu Asp Phe Arg 
            20                  25                  30          


Asp Phe Cys Leu Glu Ile Leu Pro Tyr Ser Gly Ser Met Met Gly Gly 
        35                  40                  45              


Lys Asp Phe Val Val Arg His Phe Lys Met Ser Ser Pro Thr Asp Ala 
    50                  55                  60                  


Ser Val Ile Cys Arg Phe Lys Asp Ser Ile Gln Thr Leu Gly His Val 
65                  70                  75                  80  


Asp Ser Ser Gly Gln Val His Cys Val Ser Pro Leu Leu Tyr Glu Ser 
                85                  90                  95      


Gly Arg Ile Pro Phe Thr Val Ser Leu Asp Asn Gly His Ser Phe Pro 
            100                 105                 110         


Arg Ala Gly Thr Trp Leu Ala Val His Pro Asn Lys Val Ser Met Met 
        115                 120                 125             


Glu Lys Ser Glu Leu Val Asn Glu Thr Arg Trp Gln Tyr Tyr Gly Thr 
    130                 135                 140                 


Ala Asn Thr Ser Gly Asn Leu Ser Leu Thr Trp His Val Lys Ser Leu 
145                 150                 155                 160 


Pro Thr Gln Thr Ile Thr Ile Glu Leu Trp Gly Tyr Glu Glu Thr Gly 
                165                 170                 175     


Met Pro Tyr Ser Gln Glu Trp Thr Ala Lys Trp Ser Tyr Leu Tyr Pro 
            180                 185                 190         


Leu Ala Thr His Ile Pro Asn Ser Gly Ser Phe Thr Phe Thr Pro Lys 
        195                 200                 205             


Pro Ala Pro Pro Ser Tyr Gln Arg Trp Arg Val Gly Ala Leu Arg Ile 
    210                 215                 220                 


Ile Asp Ser Lys Asn Tyr Ala Gly Gln Lys Asp Val Gln Ala Leu Trp 
225                 230                 235                 240 


Thr Asn Asp His Ala Leu Ala Trp His Leu Ser Asp Asp Phe Arg Glu 
                245                 250                 255     


Asp Pro Val Ala Trp Ala Arg Thr Gln Cys Gln Ala Trp Glu Glu Leu 
            260                 265                 270         


Glu Asp Gln Leu Pro Asn Phe Leu Glu Glu Leu Pro Asp Cys Pro Cys 
        275                 280                 285             


Thr Leu Thr Gln Ala Arg Ala Asp Ser Gly Arg Phe Phe Thr Asp Tyr 
    290                 295                 300                 


Gly Cys Asp Met Glu Gln Gly Ser Val Cys Thr Tyr His Pro Gly Ala 
305                 310                 315                 320 


Val His Cys Val Arg Ser Val Gln Ala Ser Leu Arg Tyr Gly Ser Gly 
                325                 330                 335     


Gln Gln Cys Cys Tyr Thr Ala Asp Gly Thr Gln Leu Leu Thr Ala Asp 
            340                 345                 350         


Ser Ser Gly Gly Ser Thr Pro Asp Arg Gly His Asp Trp Gly Ala Pro 
        355                 360                 365             


Pro Phe Arg Thr Pro Pro Arg Val Pro Ser Met Ser His Trp Leu Tyr 
    370                 375                 380                 


Asp Val Leu Ser Phe Tyr Tyr Cys Cys Leu Trp Ala Pro Asp Cys Pro 
385                 390                 395                 400 


Arg Tyr Met Gln Arg Arg Pro Ser Asn Asp Cys Arg Asn Tyr Arg Pro 
                405                 410                 415     


Pro Arg Leu Ala Ser Ala Phe Gly Asp Pro His Phe Val Thr Phe Asp 
            420                 425                 430         


Gly Thr Asn Phe Thr Phe Asn Gly Arg Gly Glu Tyr Val Leu Leu Glu 
        435                 440                 445             


Ala Ala Leu Thr Asp Leu Arg Val Gln Ala Arg Ala Gln Pro Gly Thr 
    450                 455                 460                 


Met Ser Asn Gly Thr Glu Thr Arg Gly Thr Gly Leu Thr Ala Val Ala 
465                 470                 475                 480 


Val Gln Glu Gly Asn Ser Asp Val Val Glu Val Arg Leu Ala Asn Arg 
                485                 490                 495     


Thr Gly Gly Leu Glu Val Leu Leu Asn Gln Glu Val Leu Ser Phe Thr 
            500                 505                 510         


Glu Gln Ser Trp Met Asp Leu Lys Gly Met Phe Leu Ser Val Ala Ala 
        515                 520                 525             


Gly Asp Arg Val Ser Ile Met Leu Ala Ser Gly Ala Gly Leu Glu Val 
    530                 535                 540                 


Ser Val Gln Gly Pro Phe Leu Ser Val Ser Val Leu Leu Pro Glu Lys 
545                 550                 555                 560 


Phe Leu Thr His Thr His Gly Leu Leu Gly Thr Leu Asn Asn Asp Pro 
                565                 570                 575     


Thr Asp Asp Phe Thr Leu His Ser Gly Arg Val Leu Pro Pro Gly Thr 
            580                 585                 590         


Ser Pro Gln Glu Leu Phe Leu Phe Gly Ala Asn Trp Thr Val His Asn 
        595                 600                 605             


Ala Ser Ser Leu Leu Thr Tyr Asp Ser Trp Phe Leu Val His Asn Phe 
    610                 615                 620                 


Leu Tyr Gln Pro Lys His Asp Pro Thr Phe Glu Pro Leu Phe Pro Ser 
625                 630                 635                 640 


Glu Thr Thr Leu Asn Pro Ser Leu Ala Gln Glu Ala Ala Lys Leu Cys 
                645                 650                 655     


Gly Asp Asp His Phe Cys Asn Phe Asp Val Ala Ala Thr Gly Ser Leu 
            660                 665                 670         


Ser Thr Gly Thr Ala Thr Arg Val Ala His Gln Leu His Gln Arg Arg 
        675                 680                 685             


Met Gln Ser Leu Gln Pro Val Val Ser Cys Gly Trp Leu Ala Pro Pro 
    690                 695                 700                 


Pro Asn Gly Gln Lys Glu Gly Asn Arg Tyr Leu Ala Gly Ser Thr Ile 
705                 710                 715                 720 


Tyr Phe His Cys Asp Asn Gly Tyr Ser Leu Ala Gly Ala Glu Thr Ser 
                725                 730                 735     


Thr Cys Gln Ala Asp Gly Thr Trp Ser Ser Pro Thr Pro Lys Cys Gln 
            740                 745                 750         


Pro Gly Arg Ser Tyr Ala 
        755             


<210>  20
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Trp Ser Pro Gln Glu Glu Asp Arg Ile Ile Glu Gly Gly Ile Tyr Asp 
1               5                   10                  15      


Ala Asp Leu Asn Asp Glu Arg Val Gln Arg Ala Leu His Phe Val Ile 
            20                  25                  30          


Ser Glu Tyr Asn Lys Ala Thr Glu Asp Glu Tyr Tyr Arg Arg Leu Leu 
        35                  40                  45              


Arg Val Leu Arg Ala Arg Glu Gln Ile Val Gly Gly Val Asn Tyr Phe 
    50                  55                  60                  


Phe Asp Ile Glu Val Gly Arg Thr Ile Cys Thr Lys Ser Gln Pro Asn 
65                  70                  75                  80  


Leu Asp Thr Cys Ala Phe His Glu Gln Pro Glu Leu Gln Lys Lys Gln 
                85                  90                  95      


Leu Cys Ser Phe Gln Ile Tyr Glu Val Pro Trp Glu Asp Arg Met Ser 
            100                 105                 110         


Leu Val Asn Ser Arg Cys Gln Glu Ala 
        115                 120     


<210>  21
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21
ccggatatca gcaagcccac gtgcccacc                                         29


<210>  22
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
aaggaaaaaa gcggccgctc atttacccgg agagcgggag                             40


<210>  23
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
cccaagcttg cagcacccaa gtgtgcaccg gcac                                   34


<210>  24
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
gtgctcgagt cacgtcagag ggctggctct ctgctcg                                37


