                         SEQUENCE LISTING

<110>  VIB VZW
       UNIVERSITEIT GENT
 
<120>  Necroptosis inducing MLKL fragment and inhibitors thereof

<130>  PVDA/NEC/490

<150>  EP 14160920.6
<151>  2014-03-20

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Asn Leu Lys His Ile Ile Thr Leu Gly Gln Val Ile His Lys 
1               5                   10                  15      


Arg Cys Glu Glu Met Lys Tyr Cys Lys Lys Gln Cys Arg Arg Leu Gly 
            20                  25                  30          


His Arg Val Leu Gly Leu Ile Lys Pro Leu Glu Met Leu Gln Asp Gln 
        35                  40                  45              


Gly Lys Arg Ser Val Pro Ser Glu Lys Leu Thr Thr Ala Met Asn Arg 
    50                  55                  60                  


Phe Lys Ala Ala Leu Glu Glu Ala Asn Gly Glu Ile Glu Lys Phe Ser 
65                  70                  75                  80  


Asn Arg Ser Asn Ile Cys Arg Phe Leu Thr Ala Ser Gln Asp Lys Ile 
                85                  90                  95      


Leu Phe Lys Asp Val Asn Arg Lys Leu Ser Asp Val Trp Lys Glu Leu 
            100                 105                 110         


Ser Leu Leu Leu Gln Val Glu Gln Arg Met Pro Val Ser Pro Ile Ser 
        115                 120                 125             


Gln Gly Ala Ser Trp Ala Gln Glu Asp Gln Gln Asp Ala Asp Glu Asp 
    130                 135                 140                 


Arg Arg Ala Phe Gln Met Leu Arg Arg Asp Asn Glu Lys Ile Glu Ala 
145                 150                 155                 160 


Ser Leu Arg Arg Leu Glu Ile Asn Met Lys Glu Ile Lys Glu Thr Leu 
                165                 170                 175     


Arg Gln Tyr Leu 
            180 


<210>  2
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  posKRas

<400>  2

Ala Arg Asp Gly Arg Arg Arg Arg Arg Arg Ala Arg Ala Arg Cys Val 
1               5                   10                  15      


Ile Met 
        


<210>  3
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  3

Lys Tyr Cys Lys Lys Gln Cys Arg Arg Leu Gly His Arg 
1               5                   10              


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cell penetrating peptide TAT47-57

<400>  4

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro 
1               5                   10      


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cell penetrating peptide ECP 32-40

<400>  5

Asn Tyr Arg Trp Arg Cys Lys Asn Gln 
1               5                   


<210>  6
<211>  60
<212>  PRT
<213>  Pan troglodytes

<400>  6

Met Glu Asn Leu Lys His Ile Ile Thr Leu Gly Gln Val Ile His Lys 
1               5                   10                  15      


Arg Cys Glu Glu Met Lys Tyr Cys Lys Lys Gln Cys Arg Arg Leu Gly 
            20                  25                  30          


His Arg Val Leu Gly Leu Ile Lys Pro Leu Glu Met Leu Gln Asp Gln 
        35                  40                  45              


Gly Lys Arg Ser Val Pro Ser Glu Lys Leu Thr Thr 
    50                  55                  60  


<210>  7
<211>  59
<212>  PRT
<213>  Bos taurus

<400>  7

Met Asp Gln Leu Lys Gln Ile Ile Ser Leu Gly Arg Leu Ile Tyr Asn 
1               5                   10                  15      


Gln Cys Glu Glu Met Lys Tyr Cys Gln Lys Gln Cys Arg Arg Leu Gly 
            20                  25                  30          


Asn Arg Val Gln Ser Leu Leu Gln Pro Leu Gln Met Leu Gln Asp Gln 
        35                  40                  45              


Gly Glu Arg Asn Leu Pro Pro Gln Ile Thr Ala 
    50                  55                  


<210>  8
<211>  59
<212>  PRT
<213>  Equus caballus

<400>  8

Met Asp Lys Leu Gly Gln Ile Thr Ser Leu Gly Gln Ile Ile Tyr Lys 
1               5                   10                  15      


Gln Cys Asn Glu Met Lys Tyr Cys Gln Lys Gln Cys Gln Arg Leu Gly 
            20                  25                  30          


Gln Arg Val Asn Gly Leu Leu Gln Pro Leu Gln Met Leu Gln Thr Glu 
        35                  40                  45              


Gly Gly Arg Ser Leu Pro Asp Lys Ile Ile Asn 
    50                  55                  


<210>  9
<211>  59
<212>  PRT
<213>  Mus musculus

<400>  9

Met Asp Lys Leu Gly Gln Ile Ile Lys Leu Gly Gln Leu Ile Tyr Glu 
1               5                   10                  15      


Gln Cys Glu Lys Met Lys Tyr Cys Arg Lys Gln Cys Gln Arg Leu Gly 
            20                  25                  30          


Asn Arg Val His Gly Leu Leu Gln Pro Leu Gln Arg Leu Gln Ala Gln 
        35                  40                  45              


Gly Lys Lys Asn Leu Pro Asp Asp Ile Thr Ala 
    50                  55                  


