SEQUENCE LISTING


<110>  CELLECTIS

<120>  CD123 SPECIFIC CHIMERIC ANTIGEN RECEPTORS FOR CANCER IMMUNOTHERAPY

<130>  P81401654PCT00

<150>  PA201470137
<151>  2014-03-19

<160>  77

<210>  1

<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  signal peptide

<400>  1
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  2

<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  signal peptide

<400>  2
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  3

<211>  16
<212>  PRT
<213>  homo sapiens

<220>
<223>  FcgRIIIa hinge

<400>  3
Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
1               5                   10                  15      






<210>  4

<211>  45
<212>  PRT
<213>  homo sapiens

<220>
<223>  Fragment of T-cell surface glycoprotein CD8 alpha chain isoform 1 precursor (residues 138-206)

<400>  4
Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  5

<211>  231
<212>  PRT
<213>  homo sapiens

<220>
<223>  IgG1 hinge

<400>  5
Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  6

<211>  24
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD8alpha transmembrane domain

<400>  6
Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  7

<211>  27
<212>  PRT
<213>  homo sapiens

<220>
<223>  41BB transmembrane domain

<400>  7
Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu 
1               5                   10                  15      


Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val 
            20                  25          


<210>  8

<211>  42
<212>  PRT
<213>  homo sapiens

<220>
<223>  Fragment of 4-1BB (residues 214-255)

<400>  8
Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  9

<211>  112
<212>  PRT
<213>  homo sapiens

<220>
<223>  fragment of T-cell surface glycoprotein CD3 zeta chain

<400>  9
Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         






<210>  10

<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  10
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  11

<211>  141
<212>  PRT
<213>  artificial sequence

<220>
<223>  7G3 heavy chain variable region

<400>  11
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Val Ser Gly Thr Gly Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser 
    130                 135                 140     


<210>  12

<211>  134
<212>  PRT
<213>  artificial sequence

<220>
<223>  7G3 light chain variable region

<400>  12
Met Glu Ser Gln Thr Gln Val Leu Met Ser Leu Leu Phe Trp Val Ser 
1               5                   10                  15      


Gly Thr Cys Gly Asp Phe Val Met Thr Gln Ser Pro Ser Ser Leu Thr 
            20                  25                  30          


Val Thr Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Arg 
    130                 


<210>  13

<211>  140
<212>  PRT
<213>  artificial sequence

<220>
<223>  Old4 heavy chain variable region

<400>  13
Trp Thr Trp Arg Phe Leu Phe Val Val Ala Ala Ala Thr Gly Val Gln 
1               5                   10                  15      


Ser Gln Val Gln Leu Leu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
            20                  25                  30          


Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr 
        35                  40                  45              


Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
    50                  55                  60                  


Met Gly Gly Ile Ile Pro Ile Phe Gly Ile Val Asn Tyr Ala Gln Lys 
65                  70                  75                  80  


Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala 
                85                  90                  95      


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Arg Gly Gly Gly Ser Gly Pro Asp Val Leu Asp Ile Trp Gly 
        115                 120                 125             


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140 


<210>  14

<211>  132
<212>  PRT
<213>  artificial sequence

<220>
<223>  Old4 light chain variable region

<400>  14
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Arg Cys Val Ile Trp Met Thr Gln Ser Pro Ser Leu 
            20                  25                  30          


Leu Ser Ala Ser Thr Gly Asp Arg Val Thr Ile Ser Cys Arg Met Ser 
        35                  40                  45              


Gln Gly Ile Arg Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
    50                  55                  60                  


Ala Pro Glu Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val 
65                  70                  75                  80  


Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                85                  90                  95      


Ile Ser Ser Leu Gln Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Tyr Tyr Ser Phe Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
        115                 120                 125             


Lys Arg Thr Val 
    130         


<210>  15

<211>  115
<212>  PRT
<213>  artificial sequence

<220>
<223>  26292 heavy chain variable region

<400>  15
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  16

<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  26292 light chain variable region

<400>  16
Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Asp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  17

<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  32716 heavy chain variable region

<400>  17
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Ser Phe Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  18

<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  32716 light chain variable region

<400>  18
Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110     


<210>  19

<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  Klon43 heavy chain variable region

<400>  19
Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His Lys Phe Met 
1               5                   10                  15      


Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln 
            20                  25                  30          


Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  20

<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  Klon43 light chain variable region

<400>  20
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125         


<210>  21

<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  12F1 heavy chain variable region

<400>  21
Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser 
1               5                   10                  15      


Leu Ser Leu Thr Cys Ser Val Thr Asp Tyr Ser Ile Thr Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ser 
                85                  90                  95      


Arg Gly Glu Gly Phe Tyr Phe Asp Ser Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Arg Ser 
        115                 


<210>  22

<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  12F1 light chain variable region

<400>  22
Asp Ile Met Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly 
1               5                   10                  15      


Glu Lys Phe Thr Met Thr Cys Lys Ser Ser Gln Ser Leu Phe Phe Gly 
            20                  25                  30          


Ser Thr Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ala 
65                  70                  75                  80  


Ile Ser Ser Val Met Pro Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Asn Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  23

<211>  484
<212>  PRT
<213>  artificial sequence

<220>
<223>  7GR-1 polypeptide CAR sequence

<400>  23
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Val Ser Gly Thr Gly Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Glu Ser Gln 
145                 150                 155                 160 


Thr Gln Val Leu Met Ser Leu Leu Phe Trp Val Ser Gly Thr Cys Gly 
                165                 170                 175     


Asp Phe Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
            180                 185                 190         


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
        195                 200                 205             


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
    210                 215                 220                 


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
225                 230                 235                 240 


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                245                 250                 255     


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
            260                 265                 270         


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        275                 280                 285             


Lys Arg Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly 
    290                 295                 300                 


Tyr Gln Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu 
305                 310                 315                 320 


Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys 
                325                 330                 335     


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
            340                 345                 350         


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
        355                 360                 365             


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
    370                 375                 380                 


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
385                 390                 395                 400 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
                405                 410                 415     


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
            420                 425                 430         


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
        435                 440                 445             


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
    450                 455                 460                 


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
465                 470                 475                 480 


Leu Pro Pro Arg 
                


<210>  24

<211>  487
<212>  PRT
<213>  artificial sequence

<220>
<223>  7GR-2 polypeptide CAR sequence

<400>  24
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Val Ser Gly Thr Gly Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Glu Ser Gln 
145                 150                 155                 160 


Thr Gln Val Leu Met Ser Leu Leu Phe Trp Val Ser Gly Thr Cys Gly 
                165                 170                 175     


Asp Phe Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
            180                 185                 190         


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
        195                 200                 205             


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
    210                 215                 220                 


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
225                 230                 235                 240 


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                245                 250                 255     


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
            260                 265                 270         


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        275                 280                 285             


Lys Arg Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly 
    290                 295                 300                 


Tyr Gln Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu 
305                 310                 315                 320 


Phe Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly 
                325                 330                 335     


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
            340                 345                 350         


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
        355                 360                 365             


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
    370                 375                 380                 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
385                 390                 395                 400 


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
                405                 410                 415     


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
            420                 425                 430         


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
        435                 440                 445             


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
    450                 455                 460                 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
465                 470                 475                 480 


Met Gln Ala Leu Pro Pro Arg 
                485         


<210>  25

<211>  513
<212>  PRT
<213>  artificial sequence

<220>
<223>  7GR-3 polypeptide CAR sequence

<400>  25
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Val Ser Gly Thr Gly Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Glu Ser Gln 
145                 150                 155                 160 


Thr Gln Val Leu Met Ser Leu Leu Phe Trp Val Ser Gly Thr Cys Gly 
                165                 170                 175     


Asp Phe Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
            180                 185                 190         


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
        195                 200                 205             


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
    210                 215                 220                 


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
225                 230                 235                 240 


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                245                 250                 255     


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
            260                 265                 270         


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        275                 280                 285             


Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    290                 295                 300                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
305                 310                 315                 320 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
                325                 330                 335     


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
            340                 345                 350         


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
        355                 360                 365             


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
    370                 375                 380                 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
385                 390                 395                 400 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
                405                 410                 415     


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
            420                 425                 430         


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
        435                 440                 445             


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    450                 455                 460                 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
465                 470                 475                 480 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                485                 490                 495     


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            500                 505                 510         


Arg 
    


<210>  26

<211>  516
<212>  PRT
<213>  artificial sequence

<220>
<223>  7GR-4 polypeptide CAR sequence

<400>  26
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Val Ser Gly Thr Gly Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Glu Ser Gln 
145                 150                 155                 160 


Thr Gln Val Leu Met Ser Leu Leu Phe Trp Val Ser Gly Thr Cys Gly 
                165                 170                 175     


Asp Phe Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
            180                 185                 190         


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
        195                 200                 205             


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
    210                 215                 220                 


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
225                 230                 235                 240 


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                245                 250                 255     


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
            260                 265                 270         


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        275                 280                 285             


Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr 
    290                 295                 300                 


Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala 
305                 310                 315                 320 


Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile 
                325                 330                 335     


Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu 
            340                 345                 350         


Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys 
        355                 360                 365             


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
    370                 375                 380                 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
385                 390                 395                 400 


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
                405                 410                 415     


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
            420                 425                 430         


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
        435                 440                 445             


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
    450                 455                 460                 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
465                 470                 475                 480 


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
                485                 490                 495     


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
            500                 505                 510         


Leu Pro Pro Arg 
        515     


<210>  27

<211>  699
<212>  PRT
<213>  artificial sequence

<220>
<223>  7GR-5 polypeptide CAR sequence

<400>  27
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Val Ser Gly Thr Gly Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Glu Ser Gln 
145                 150                 155                 160 


Thr Gln Val Leu Met Ser Leu Leu Phe Trp Val Ser Gly Thr Cys Gly 
                165                 170                 175     


Asp Phe Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
            180                 185                 190         


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
        195                 200                 205             


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
    210                 215                 220                 


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
225                 230                 235                 240 


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                245                 250                 255     


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
            260                 265                 270         


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        275                 280                 285             


Lys Arg Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys 
    290                 295                 300                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
305                 310                 315                 320 


Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
                325                 330                 335     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            340                 345                 350         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        355                 360                 365             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    370                 375                 380                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
385                 390                 395                 400 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                405                 410                 415     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            420                 425                 430         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        435                 440                 445             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    450                 455                 460                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
465                 470                 475                 480 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                485                 490                 495     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            500                 505                 510         


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Tyr Ile Trp Ala Pro Leu 
        515                 520                 525             


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
    530                 535                 540                 


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
545                 550                 555                 560 


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
                565                 570                 575     


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
            580                 585                 590         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        595                 600                 605             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    610                 615                 620                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
625                 630                 635                 640 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                645                 650                 655     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            660                 665                 670         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        675                 680                 685             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    690                 695                 


<210>  28

<211>  702
<212>  PRT
<213>  artificial sequence

<220>
<223>  7GR-6 polypeptide CAR sequence

<400>  28
Met Gly Trp Ser Trp Ile Phe Leu Phe Leu Val Ser Gly Thr Gly Gly 
1               5                   10                  15      


Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Lys Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Ile Pro Ser Asn Gly Ala Thr Phe Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Arg Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Asn Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Ser His Leu Leu Arg Ala Ser Trp Phe Ala Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Glu Ser Gln 
145                 150                 155                 160 


Thr Gln Val Leu Met Ser Leu Leu Phe Trp Val Ser Gly Thr Cys Gly 
                165                 170                 175     


Asp Phe Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly 
            180                 185                 190         


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
        195                 200                 205             


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Leu Gln Lys Pro Gly Gln 
    210                 215                 220                 


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
225                 230                 235                 240 


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
                245                 250                 255     


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn 
            260                 265                 270         


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile 
        275                 280                 285             


Lys Arg Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys 
    290                 295                 300                 


Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
305                 310                 315                 320 


Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
                325                 330                 335     


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
            340                 345                 350         


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
        355                 360                 365             


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
    370                 375                 380                 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
385                 390                 395                 400 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
                405                 410                 415     


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
            420                 425                 430         


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
        435                 440                 445             


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
    450                 455                 460                 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
465                 470                 475                 480 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
                485                 490                 495     


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
            500                 505                 510         


Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Ile Ser Phe Phe Leu Ala 
        515                 520                 525             


Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu Arg 
    530                 535                 540                 


Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
545                 550                 555                 560 


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
                565                 570                 575     


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
            580                 585                 590         


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
        595                 600                 605             


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
    610                 615                 620                 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
625                 630                 635                 640 


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
                645                 650                 655     


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
            660                 665                 670         


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
        675                 680                 685             


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    690                 695                 700         


<210>  29

<211>  510
<212>  PRT
<213>  artificial sequence

<220>
<223>  Old4-3 polypeptide CAR sequence

<400>  29
Trp Thr Trp Arg Phe Leu Phe Val Val Ala Ala Ala Thr Gly Val Gln 
1               5                   10                  15      


Ser Gln Val Gln Leu Leu Gln Ser Gly Ala Glu Val Lys Lys Pro Gly 
            20                  25                  30          


Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Thr 
        35                  40                  45              


Tyr Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp 
    50                  55                  60                  


Met Gly Gly Ile Ile Pro Ile Phe Gly Ile Val Asn Tyr Ala Gln Lys 
65                  70                  75                  80  


Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala 
                85                  90                  95      


Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr 
            100                 105                 110         


Cys Ala Arg Gly Gly Gly Ser Gly Pro Asp Val Leu Asp Ile Trp Gly 
        115                 120                 125             


Gln Gly Thr Met Val Thr Val Ser Ser Ala Ser Thr Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Asp Met Arg Val 
145                 150                 155                 160 


Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp Leu Pro Gly Ala Arg 
                165                 170                 175     


Cys Val Ile Trp Met Thr Gln Ser Pro Ser Leu Leu Ser Ala Ser Thr 
            180                 185                 190         


Gly Asp Arg Val Thr Ile Ser Cys Arg Met Ser Gln Gly Ile Arg Ser 
        195                 200                 205             


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu 
    210                 215                 220                 


Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser 
225                 230                 235                 240 


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
                245                 250                 255     


Ser Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Phe Pro 
            260                 265                 270         


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Thr 
        275                 280                 285             


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
    290                 295                 300                 


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
305                 310                 315                 320 


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
                325                 330                 335     


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
            340                 345                 350         


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
        355                 360                 365             


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
    370                 375                 380                 


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
385                 390                 395                 400 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
                405                 410                 415     


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
            420                 425                 430         


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
        435                 440                 445             


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
    450                 455                 460                 


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
465                 470                 475                 480 


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
                485                 490                 495     


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505                 510 


<210>  30

<211>  431
<212>  PRT
<213>  artificial sequence

<220>
<223>  26292-1 polypeptide CAR sequence

<400>  30
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser 
    130                 135                 140                 


Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser 
145                 150                 155                 160 


Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu 
                165                 170                 175     


Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        195                 200                 205             


Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr 
    210                 215                 220                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Leu Ala 
225                 230                 235                 240 


Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Ile Tyr Ile 
                245                 250                 255     


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
            260                 265                 270         


Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
        275                 280                 285             


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
    290                 295                 300                 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
305                 310                 315                 320 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
                325                 330                 335     


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
            340                 345                 350         


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
        355                 360                 365             


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
    370                 375                 380                 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
385                 390                 395                 400 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
                405                 410                 415     


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425                 430     


<210>  31

<211>  434
<212>  PRT
<213>  artificial sequence

<220>
<223>  26292-2 polypeptide CAR sequence

<400>  31
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser 
    130                 135                 140                 


Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser 
145                 150                 155                 160 


Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu 
                165                 170                 175     


Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        195                 200                 205             


Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr 
    210                 215                 220                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Leu Ala 
225                 230                 235                 240 


Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Ile Ile Ser 
                245                 250                 255     


Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe 
            260                 265                 270         


Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu 
        275                 280                 285             


Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu 
    290                 295                 300                 


Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys 
305                 310                 315                 320 


Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln 
                325                 330                 335     


Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu 
            340                 345                 350         


Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly 
        355                 360                 365             


Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu 
    370                 375                 380                 


Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly 
385                 390                 395                 400 


Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser 
                405                 410                 415     


Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro 
            420                 425                 430         


Pro Arg 
        


<210>  32

<211>  460
<212>  PRT
<213>  artificial sequence

<220>
<223>  26292-3 polypeptide CAR sequence

<400>  32
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser 
    130                 135                 140                 


Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser 
145                 150                 155                 160 


Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu 
                165                 170                 175     


Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        195                 200                 205             


Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr 
    210                 215                 220                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr 
225                 230                 235                 240 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
                245                 250                 255     


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
            260                 265                 270         


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
        275                 280                 285             


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
    290                 295                 300                 


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
305                 310                 315                 320 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                325                 330                 335     


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
            340                 345                 350         


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        355                 360                 365             


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    370                 375                 380                 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
385                 390                 395                 400 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                405                 410                 415     


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            420                 425                 430         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        435                 440                 445             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460 


<210>  33

<211>  463
<212>  PRT
<213>  artificial sequence

<220>
<223>  26292-4 polypeptide CAR sequence

<400>  33
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser 
    130                 135                 140                 


Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser 
145                 150                 155                 160 


Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu 
                165                 170                 175     


Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        195                 200                 205             


Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr 
    210                 215                 220                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr 
225                 230                 235                 240 


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
                245                 250                 255     


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
            260                 265                 270         


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Ile Ser Phe Phe Leu 
        275                 280                 285             


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
    290                 295                 300                 


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
305                 310                 315                 320 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
                325                 330                 335     


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg 
            340                 345                 350         


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
        355                 360                 365             


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
    370                 375                 380                 


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
385                 390                 395                 400 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
                405                 410                 415     


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
            420                 425                 430         


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
        435                 440                 445             


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460             


<210>  34

<211>  646
<212>  PRT
<213>  artificial sequence

<220>
<223>  26292-5 polypeptide CAR sequence

<400>  34
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser 
    130                 135                 140                 


Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser 
145                 150                 155                 160 


Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu 
                165                 170                 175     


Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        195                 200                 205             


Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr 
    210                 215                 220                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Pro Lys 
225                 230                 235                 240 


Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
                245                 250                 255     


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
465                 470                 475                 480 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
                485                 490                 495     


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
            500                 505                 510         


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
        515                 520                 525             


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
    530                 535                 540                 


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
545                 550                 555                 560 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
                565                 570                 575     


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
            580                 585                 590         


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
        595                 600                 605             


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
    610                 615                 620                 


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
625                 630                 635                 640 


Gln Ala Leu Pro Pro Arg 
                645     


<210>  35

<211>  649
<212>  PRT
<213>  artificial sequence

<220>
<223>  26292-6 polypeptide CAR sequence

<400>  35
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Trp Asp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser 
    130                 135                 140                 


Pro Gly Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser 
145                 150                 155                 160 


Lys Asp Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu 
                165                 170                 175     


Leu Ile Tyr Ser Gly Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        195                 200                 205             


Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln His Asn Lys Tyr 
    210                 215                 220                 


Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Glu Pro Lys 
225                 230                 235                 240 


Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val 
                245                 250                 255     


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala 
465                 470                 475                 480 


Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys 
                485                 490                 495     


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
            500                 505                 510         


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
        515                 520                 525             


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
    530                 535                 540                 


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
545                 550                 555                 560 


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
                565                 570                 575     


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
            580                 585                 590         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        595                 600                 605             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    610                 615                 620                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
625                 630                 635                 640 


Leu His Met Gln Ala Leu Pro Pro Arg 
                645                 


<210>  36

<211>  438
<212>  PRT
<213>  artificial sequence

<220>
<223>  32716-1 polypeptide CAR sequence

<400>  36
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Ser Phe Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
    130                 135                 140                 


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
145                 150                 155                 160 


Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu 
            180                 185                 190         


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro 
                245                 250                 255     


Pro Gly Tyr Gln Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
            260                 265                 270         


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
        275                 280                 285             


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
    290                 295                 300                 


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
305                 310                 315                 320 


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
                325                 330                 335     


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
            340                 345                 350         


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
        355                 360                 365             


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
    370                 375                 380                 


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
385                 390                 395                 400 


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
                405                 410                 415     


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
            420                 425                 430         


Gln Ala Leu Pro Pro Arg 
        435             


<210>  37

<211>  441
<212>  PRT
<213>  artificial sequence

<220>
<223>  32716-2 polypeptide CAR sequence

<400>  37
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Ser Phe Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
    130                 135                 140                 


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
145                 150                 155                 160 


Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu 
            180                 185                 190         


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro 
                245                 250                 255     


Pro Gly Tyr Gln Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala 
            260                 265                 270         


Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys 
        275                 280                 285             


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
    290                 295                 300                 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
305                 310                 315                 320 


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
                325                 330                 335     


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
            340                 345                 350         


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
        355                 360                 365             


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
    370                 375                 380                 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
385                 390                 395                 400 


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
                405                 410                 415     


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
            420                 425                 430         


Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440     


<210>  38

<211>  467
<212>  PRT
<213>  artificial sequence

<220>
<223>  32716-3 polypeptide CAR sequence

<400>  38
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Ser Phe Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
    130                 135                 140                 


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
145                 150                 155                 160 


Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu 
            180                 185                 190         


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
    290                 295                 300                 


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
305                 310                 315                 320 


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
                325                 330                 335     


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
            340                 345                 350         


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        355                 360                 365             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    370                 375                 380                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
385                 390                 395                 400 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                405                 410                 415     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            420                 425                 430         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        435                 440                 445             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    450                 455                 460                 


Pro Pro Arg 
465         


<210>  39

<211>  470
<212>  PRT
<213>  artificial sequence

<220>
<223>  32716-4 polypeptide CAR sequence

<400>  39
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Ser Phe Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
    130                 135                 140                 


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
145                 150                 155                 160 


Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu 
            180                 185                 190         


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
                245                 250                 255     


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
            260                 265                 270         


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
        275                 280                 285             


Asp Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe 
    290                 295                 300                 


Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg 
305                 310                 315                 320 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
                325                 330                 335     


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
            340                 345                 350         


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        355                 360                 365             


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    370                 375                 380                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
385                 390                 395                 400 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                405                 410                 415     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            420                 425                 430         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        435                 440                 445             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    450                 455                 460                 


Gln Ala Leu Pro Pro Arg 
465                 470 


<210>  40

<211>  653
<212>  PRT
<213>  artificial sequence

<220>
<223>  32716-5 polypeptide CAR sequence

<400>  40
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Ser Phe Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
    130                 135                 140                 


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
145                 150                 155                 160 


Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu 
            180                 185                 190         


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Tyr Ile Trp Ala 
465                 470                 475                 480 


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
                485                 490                 495     


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
            500                 505                 510         


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
        515                 520                 525             


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
    530                 535                 540                 


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
545                 550                 555                 560 


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
                565                 570                 575     


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
            580                 585                 590         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        595                 600                 605             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    610                 615                 620                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
625                 630                 635                 640 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                645                 650             


<210>  41

<211>  656
<212>  PRT
<213>  artificial sequence

<220>
<223>  32716-6 polypeptide CAR sequence

<400>  41
Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Lys Gln Ala Pro Gly Lys Ser Phe Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Ser Thr Tyr Ser Ala Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu His Ile Asn Asp Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Gly Gly Tyr Asp Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
    130                 135                 140                 


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
145                 150                 155                 160 


Ser Val Asp Asn Tyr Gly Asn Thr Phe Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu 
            180                 185                 190         


Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Asn Glu Asp Pro Pro Thr Phe Gly Ala Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Leu Lys Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Ile Ser Phe Phe 
465                 470                 475                 480 


Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr 
                485                 490                 495     


Leu Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
            500                 505                 510         


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
        515                 520                 525             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    530                 535                 540                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
545                 550                 555                 560 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                565                 570                 575     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            580                 585                 590         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        595                 600                 605             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    610                 615                 620                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
625                 630                 635                 640 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                645                 650                 655     






<210>  42

<211>  449
<212>  PRT
<213>  artificial sequence

<220>
<223>  Klo43-1 polypeptide CAR sequence

<400>  42
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala 
    130                 135                 140                 


Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
            180                 185                 190         


Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg 
        195                 200                 205             


Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
    210                 215                 220                 


Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser 
225                 230                 235                 240 


Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly 
                245                 250                 255     


Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Ile 
            260                 265                 270         


Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser 
        275                 280                 285             


Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
    290                 295                 300                 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
305                 310                 315                 320 


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
                325                 330                 335     


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
            340                 345                 350         


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
        355                 360                 365             


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
    370                 375                 380                 


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
385                 390                 395                 400 


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
                405                 410                 415     


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
            420                 425                 430         


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
        435                 440                 445             


Arg 
    


<210>  43

<211>  452
<212>  PRT
<213>  artificial sequence

<220>
<223>  Klo43-2 polypeptide CAR sequence

<400>  43
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala 
    130                 135                 140                 


Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
            180                 185                 190         


Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg 
        195                 200                 205             


Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
    210                 215                 220                 


Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser 
225                 230                 235                 240 


Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Gly 
                245                 250                 255     


Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln Ile 
            260                 265                 270         


Ile Ser Phe Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu 
        275                 280                 285             


Phe Phe Leu Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys 
    290                 295                 300                 


Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr 
305                 310                 315                 320 


Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly 
                325                 330                 335     


Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
            340                 345                 350         


Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
        355                 360                 365             


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
    370                 375                 380                 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
385                 390                 395                 400 


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
                405                 410                 415     


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
            420                 425                 430         


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
        435                 440                 445             


Leu Pro Pro Arg 
    450         


<210>  44

<211>  478
<212>  PRT
<213>  artificial sequence

<220>
<223>  Klo43-3 polypeptide CAR sequence

<400>  44
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala 
    130                 135                 140                 


Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
            180                 185                 190         


Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg 
        195                 200                 205             


Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
    210                 215                 220                 


Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser 
225                 230                 235                 240 


Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
                245                 250                 255     


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
            260                 265                 270         


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
        275                 280                 285             


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp 
    290                 295                 300                 


Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile 
305                 310                 315                 320 


Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys 
                325                 330                 335     


Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys 
            340                 345                 350         


Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val 
        355                 360                 365             


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn 
    370                 375                 380                 


Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val 
385                 390                 395                 400 


Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg 
                405                 410                 415     


Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys 
            420                 425                 430         


Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg 
        435                 440                 445             


Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys 
    450                 455                 460                 


Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
465                 470                 475             


<210>  45

<211>  481
<212>  PRT
<213>  artificial sequence

<220>
<223>  Klo43-4 polypeptide CAR sequence

<400>  45
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala 
    130                 135                 140                 


Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
            180                 185                 190         


Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg 
        195                 200                 205             


Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
    210                 215                 220                 


Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser 
225                 230                 235                 240 


Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr 
                245                 250                 255     


Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser 
            260                 265                 270         


Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly 
        275                 280                 285             


Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Ile Ser Phe 
    290                 295                 300                 


Phe Leu Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu 
305                 310                 315                 320 


Thr Leu Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
                325                 330                 335     


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
            340                 345                 350         


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        355                 360                 365             


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
    370                 375                 380                 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
385                 390                 395                 400 


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
                405                 410                 415     


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
            420                 425                 430         


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
        435                 440                 445             


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
    450                 455                 460                 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
465                 470                 475                 480 


Arg 
    


<210>  46

<211>  664
<212>  PRT
<213>  artificial sequence

<220>
<223>  Klo43-5 polypeptide CAR sequence

<400>  46
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala 
    130                 135                 140                 


Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
            180                 185                 190         


Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg 
        195                 200                 205             


Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
    210                 215                 220                 


Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser 
225                 230                 235                 240 


Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Glu 
                245                 250                 255     


Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            260                 265                 270         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        275                 280                 285             


Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    290                 295                 300                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
305                 310                 315                 320 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                325                 330                 335     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            340                 345                 350         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        355                 360                 365             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    370                 375                 380                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
385                 390                 395                 400 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                405                 410                 415     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            420                 425                 430         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        435                 440                 445             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    450                 455                 460                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
465                 470                 475                 480 


Ser Leu Ser Pro Gly Lys Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr 
                485                 490                 495     


Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg 
            500                 505                 510         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        515                 520                 525             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    530                 535                 540                 


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
545                 550                 555                 560 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
                565                 570                 575     


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
            580                 585                 590         


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
        595                 600                 605             


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
    610                 615                 620                 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
625                 630                 635                 640 


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
                645                 650                 655     


His Met Gln Ala Leu Pro Pro Arg 
            660                 


<210>  47

<211>  667
<212>  PRT
<213>  artificial sequence

<220>
<223>  Klo43-6 polypeptide CAR sequence

<400>  47
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 
        35                  40                  45              


Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp Asp Ser Gln Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu Asp Ser Ala Thr Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Met Ala 
    130                 135                 140                 


Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr 
145                 150                 155                 160 


Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asn Val 
                165                 170                 175     


Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
            180                 185                 190         


Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg 
        195                 200                 205             


Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
    210                 215                 220                 


Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser 
225                 230                 235                 240 


Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Glu 
                245                 250                 255     


Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
            260                 265                 270         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        275                 280                 285             


Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    290                 295                 300                 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
305                 310                 315                 320 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
                325                 330                 335     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            340                 345                 350         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
        355                 360                 365             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    370                 375                 380                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
385                 390                 395                 400 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                405                 410                 415     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            420                 425                 430         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        435                 440                 445             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    450                 455                 460                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
465                 470                 475                 480 


Ser Leu Ser Pro Gly Lys Ile Ile Ser Phe Phe Leu Ala Leu Thr Ser 
                485                 490                 495     


Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu Arg Phe Ser Val 
            500                 505                 510         


Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        515                 520                 525             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    530                 535                 540                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
545                 550                 555                 560 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
                565                 570                 575     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            580                 585                 590         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        595                 600                 605             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    610                 615                 620                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
625                 630                 635                 640 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                645                 650                 655     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            660                 665         


<210>  48

<211>  470
<212>  PRT
<213>  artificial sequence

<220>
<223>  12F1-3 polypeptide CAR sequence

<400>  48
Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Ser 
1               5                   10                  15      


Leu Ser Leu Thr Cys Ser Val Thr Asp Tyr Ser Ile Thr Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ser 
                85                  90                  95      


Arg Gly Glu Gly Phe Tyr Phe Asp Ser Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser Ala Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Met Met Ser Gln Ser Pro Ser Ser 
    130                 135                 140                 


Leu Ala Val Ser Val Gly Glu Lys Phe Thr Met Thr Cys Lys Ser Ser 
145                 150                 155                 160 


Gln Ser Leu Phe Phe Gly Ser Thr Gln Lys Asn Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser 
            180                 185                 190         


Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Ala Ile Ser Ser Val Met Pro Glu Asp Leu Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Gln Gln Tyr Tyr Asn Tyr Pro Trp Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Thr Thr Thr Pro Ala Pro Arg Pro Pro 
                245                 250                 255     


Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu 
            260                 265                 270         


Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp 
        275                 280                 285             


Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
    290                 295                 300                 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
305                 310                 315                 320 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
                325                 330                 335     


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
            340                 345                 350         


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        355                 360                 365             


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    370                 375                 380                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
385                 390                 395                 400 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                405                 410                 415     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            420                 425                 430         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        435                 440                 445             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    450                 455                 460                 


Gln Ala Leu Pro Pro Arg 
465                 470 


<210>  49

<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Target TALEN TRAC_T01

<400>  49
Thr Thr Gly Thr Cys Cys Cys Ala Cys Ala Gly Ala Thr Ala Thr Cys 
1               5                   10                  15      


Cys Ala Gly Ala Ala Cys Cys Cys Thr Gly Ala Cys Cys Cys Thr Gly 
            20                  25                  30          


Cys Cys Gly Thr Gly Thr Ala Cys Cys Ala Gly Cys Thr Gly Ala Gly 
        35                  40                  45              


Ala 
    


<210>  50

<211>  530
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAL binding domain  TRAC_T01-L

<400>  50
Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
        35                  40                  45              


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    50                  55                  60                  


Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn 
65                  70                  75                  80  


Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                85                  90                  95      


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
            100                 105                 110         


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
        115                 120                 125             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
225                 230                 235                 240 


Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            260                 265                 270         


Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala 
    290                 295                 300                 


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            340                 345                 350         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            500                 505                 510         


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 
        515                 520                 525             


Leu Glu 
    530 


<210>  51

<211>  530
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TAL binding domain TRAC_T01-R

<400>  51
Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys 
1               5                   10                  15      


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
            20                  25                  30          


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
        35                  40                  45              


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
    50                  55                  60                  


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His 
65                  70                  75                  80  


Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val 
                85                  90                  95      


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
            100                 105                 110         


Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu 
        115                 120                 125             


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala 
    130                 135                 140                 


Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg 
145                 150                 155                 160 


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
                165                 170                 175     


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
            180                 185                 190         


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
        195                 200                 205             


Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu 
    210                 215                 220                 


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
225                 230                 235                 240 


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala 
                245                 250                 255     


Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly 
            260                 265                 270         


Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys 
        275                 280                 285             


Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala 
    290                 295                 300                 


His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly 
305                 310                 315                 320 


Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys 
                325                 330                 335     


Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn 
            340                 345                 350         


Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val 
        355                 360                 365             


Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala 
    370                 375                 380                 


Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu 
385                 390                 395                 400 


Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala 
                405                 410                 415     


Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Ala 
            420                 425                 430         


Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val 
        435                 440                 445             


Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val 
    450                 455                 460                 


Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln 
465                 470                 475                 480 


Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu 
                485                 490                 495     


Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr 
            500                 505                 510         


Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Arg Pro Ala 
        515                 520                 525             


Leu Glu 
    530 


<210>  52

<211>  2814
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polynucleotide encoding  TRAC_T01-L TALEN

<400>  52
Ala Thr Gly Gly Gly Cys Gly Ala Thr Cys Cys Thr Ala Ala Ala Ala 
1               5                   10                  15      


Ala Gly Ala Ala Ala Cys Gly Thr Ala Ala Gly Gly Thr Cys Ala Thr 
            20                  25                  30          


Cys Gly Ala Thr Thr Ala Cys Cys Cys Ala Thr Ala Cys Gly Ala Thr 
        35                  40                  45              


Gly Thr Thr Cys Cys Ala Gly Ala Thr Thr Ala Cys Gly Cys Thr Ala 
    50                  55                  60                  


Thr Cys Gly Ala Thr Ala Thr Cys Gly Cys Cys Gly Ala Thr Cys Thr 
65                  70                  75                  80  


Ala Cys Gly Cys Ala Cys Gly Cys Thr Cys Gly Gly Cys Thr Ala Cys 
                85                  90                  95      


Ala Gly Cys Cys Ala Gly Cys Ala Gly Cys Ala Ala Cys Ala Gly Gly 
            100                 105                 110         


Ala Gly Ala Ala Gly Ala Thr Cys Ala Ala Ala Cys Cys Gly Ala Ala 
        115                 120                 125             


Gly Gly Thr Thr Cys Gly Thr Thr Cys Gly Ala Cys Ala Gly Thr Gly 
    130                 135                 140                 


Gly Cys Gly Cys Ala Gly Cys Ala Cys Cys Ala Cys Gly Ala Gly Gly 
145                 150                 155                 160 


Cys Ala Cys Thr Gly Gly Thr Cys Gly Gly Cys Cys Ala Cys Gly Gly 
                165                 170                 175     


Gly Thr Thr Thr Ala Cys Ala Cys Ala Cys Gly Cys Gly Cys Ala Cys 
            180                 185                 190         


Ala Thr Cys Gly Thr Thr Gly Cys Gly Thr Thr Ala Ala Gly Cys Cys 
        195                 200                 205             


Ala Ala Cys Ala Cys Cys Cys Gly Gly Cys Ala Gly Cys Gly Thr Thr 
    210                 215                 220                 


Ala Gly Gly Gly Ala Cys Cys Gly Thr Cys Gly Cys Thr Gly Thr Cys 
225                 230                 235                 240 


Ala Ala Gly Thr Ala Thr Cys Ala Gly Gly Ala Cys Ala Thr Gly Ala 
                245                 250                 255     


Thr Cys Gly Cys Ala Gly Cys Gly Thr Thr Gly Cys Cys Ala Gly Ala 
            260                 265                 270         


Gly Gly Cys Gly Ala Cys Ala Cys Ala Cys Gly Ala Ala Gly Cys Gly 
        275                 280                 285             


Ala Thr Cys Gly Thr Thr Gly Gly Cys Gly Thr Cys Gly Gly Cys Ala 
    290                 295                 300                 


Ala Ala Cys Ala Gly Thr Gly Gly Thr Cys Cys Gly Gly Cys Gly Cys 
305                 310                 315                 320 


Ala Cys Gly Cys Gly Cys Thr Cys Thr Gly Gly Ala Gly Gly Cys Cys 
                325                 330                 335     


Thr Thr Gly Cys Thr Cys Ala Cys Gly Gly Thr Gly Gly Cys Gly Gly 
            340                 345                 350         


Gly Ala Gly Ala Gly Thr Thr Gly Ala Gly Ala Gly Gly Thr Cys Cys 
        355                 360                 365             


Ala Cys Cys Gly Thr Thr Ala Cys Ala Gly Thr Thr Gly Gly Ala Cys 
    370                 375                 380                 


Ala Cys Ala Gly Gly Cys Cys Ala Ala Cys Thr Thr Cys Thr Cys Ala 
385                 390                 395                 400 


Ala Gly Ala Thr Thr Gly Cys Ala Ala Ala Ala Cys Gly Thr Gly Gly 
                405                 410                 415     


Cys Gly Gly Cys Gly Thr Gly Ala Cys Cys Gly Cys Ala Gly Thr Gly 
            420                 425                 430         


Gly Ala Gly Gly Cys Ala Gly Thr Gly Cys Ala Thr Gly Cys Ala Thr 
        435                 440                 445             


Gly Gly Cys Gly Cys Ala Ala Thr Gly Cys Ala Cys Thr Gly Ala Cys 
    450                 455                 460                 


Gly Gly Gly Thr Gly Cys Cys Cys Cys Gly Cys Thr Cys Ala Ala Cys 
465                 470                 475                 480 


Thr Thr Gly Ala Cys Cys Cys Cys Cys Cys Ala Gly Cys Ala Gly Gly 
                485                 490                 495     


Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly 
            500                 505                 510         


Cys Ala Ala Thr Gly Gly Cys Gly Gly Thr Gly Gly Cys Ala Ala Gly 
        515                 520                 525             


Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Gly Ala Cys Gly Gly 
    530                 535                 540                 


Thr Cys Cys Ala Gly Cys Gly Gly Cys Thr Gly Thr Thr Gly Cys Cys 
545                 550                 555                 560 


Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Cys Cys 
                565                 570                 575     


Cys Ala Cys Gly Gly Cys Thr Thr Gly Ala Cys Cys Cys Cys Cys Cys 
            580                 585                 590         


Ala Gly Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr 
        595                 600                 605             


Cys Gly Cys Cys Ala Gly Cys Ala Ala Thr Ala Ala Thr Gly Gly Thr 
    610                 615                 620                 


Gly Gly Cys Ala Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly 
625                 630                 635                 640 


Ala Gly Ala Cys Gly Gly Thr Cys Cys Ala Gly Cys Gly Gly Cys Thr 
                645                 650                 655     


Gly Thr Thr Gly Cys Cys Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys 
            660                 665                 670         


Cys Ala Gly Gly Cys Cys Cys Ala Cys Gly Gly Cys Thr Thr Gly Ala 
        675                 680                 685             


Cys Cys Cys Cys Cys Cys Ala Gly Cys Ala Gly Gly Thr Gly Gly Thr 
    690                 695                 700                 


Gly Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Ala Ala Thr 
705                 710                 715                 720 


Gly Gly Cys Gly Gly Thr Gly Gly Cys Ala Ala Gly Cys Ala Gly Gly 
                725                 730                 735     


Cys Gly Cys Thr Gly Gly Ala Gly Ala Cys Gly Gly Thr Cys Cys Ala 
            740                 745                 750         


Gly Cys Gly Gly Cys Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Gly 
        755                 760                 765             


Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Cys Cys Cys Ala Cys Gly 
    770                 775                 780                 


Gly Cys Thr Thr Gly Ala Cys Cys Cys Cys Gly Gly Ala Gly Cys Ala 
785                 790                 795                 800 


Gly Gly Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr Cys Gly Cys Cys 
                805                 810                 815     


Ala Gly Cys Cys Ala Cys Gly Ala Thr Gly Gly Cys Gly Gly Cys Ala 
            820                 825                 830         


Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Gly Ala Cys 
        835                 840                 845             


Gly Gly Thr Cys Cys Ala Gly Cys Gly Gly Cys Thr Gly Thr Thr Gly 
    850                 855                 860                 


Cys Cys Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly 
865                 870                 875                 880 


Cys Cys Cys Ala Cys Gly Gly Cys Thr Thr Gly Ala Cys Cys Cys Cys 
                885                 890                 895     


Gly Gly Ala Gly Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly Cys Cys 
            900                 905                 910         


Ala Thr Cys Gly Cys Cys Ala Gly Cys Cys Ala Cys Gly Ala Thr Gly 
        915                 920                 925             


Gly Cys Gly Gly Cys Ala Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr 
    930                 935                 940                 


Gly Gly Ala Gly Ala Cys Gly Gly Thr Cys Cys Ala Gly Cys Gly Gly 
945                 950                 955                 960 


Cys Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Gly Cys Thr Gly Thr 
                965                 970                 975     


Gly Cys Cys Ala Gly Gly Cys Cys Cys Ala Cys Gly Gly Cys Thr Thr 
            980                 985                 990         


Gly Ala Cys Cys Cys Cys Gly Gly Ala Gly Cys Ala Gly Gly Thr Gly 
        995                 1000                1005            


Gly Thr Gly Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Cys 
    1010                1015                1020                


Ala Cys Gly Ala Thr Gly Gly Cys Gly Gly Cys Ala Ala Gly Cys Ala 
1025                1030                1035                1040


Gly Gly Cys Gly Cys Thr Gly Gly Ala Gly Ala Cys Gly Gly Thr Cys 
                1045                1050                1055    


Cys Ala Gly Cys Gly Gly Cys Thr Gly Thr Thr Gly Cys Cys Gly Gly 
            1060                1065                1070        


Thr Gly Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Cys Cys Cys Ala 
        1075                1080                1085            


Cys Gly Gly Cys Thr Thr Gly Ala Cys Cys Cys Cys Gly Gly Ala Gly 
    1090                1095                1100                


Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr Cys Gly 
1105                1110                1115                1120


Cys Cys Ala Gly Cys Ala Ala Thr Ala Thr Thr Gly Gly Thr Gly Gly 
                1125                1130                1135    


Cys Ala Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Gly 
            1140                1145                1150        


Ala Cys Gly Gly Thr Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly Thr 
        1155                1160                1165            


Thr Gly Cys Cys Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys Cys Ala 
    1170                1175                1180                


Gly Gly Cys Cys Cys Ala Cys Gly Gly Cys Thr Thr Gly Ala Cys Cys 
1185                1190                1195                1200


Cys Cys Gly Gly Ala Gly Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly 
                1205                1210                1215    


Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Cys Ala Cys Gly Ala 
            1220                1225                1230        


Thr Gly Gly Cys Gly Gly Cys Ala Ala Gly Cys Ala Gly Gly Cys Gly 
        1235                1240                1245            


Cys Thr Gly Gly Ala Gly Ala Cys Gly Gly Thr Cys Cys Ala Gly Cys 
    1250                1255                1260                


Gly Gly Cys Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Gly Cys Thr 
1265                1270                1275                1280


Gly Thr Gly Cys Cys Ala Gly Gly Cys Cys Cys Ala Cys Gly Gly Cys 
                1285                1290                1295    


Thr Thr Gly Ala Cys Cys Cys Cys Gly Gly Ala Gly Cys Ala Gly Gly 
            1300                1305                1310        


Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly 
        1315                1320                1325            


Cys Ala Ala Thr Ala Thr Thr Gly Gly Thr Gly Gly Cys Ala Ala Gly 
    1330                1335                1340                


Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Gly Ala Cys Gly Gly 
1345                1350                1355                1360


Thr Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly Thr Thr Gly Cys Cys 
                1365                1370                1375    


Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Cys Cys 
            1380                1385                1390        


Cys Ala Cys Gly Gly Cys Thr Thr Gly Ala Cys Cys Cys Cys Cys Cys 
        1395                1400                1405            


Ala Gly Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr 
    1410                1415                1420                


Cys Gly Cys Cys Ala Gly Cys Ala Ala Thr Ala Ala Thr Gly Gly Thr 
1425                1430                1435                1440


Gly Gly Cys Ala Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly 
                1445                1450                1455    


Ala Gly Ala Cys Gly Gly Thr Cys Cys Ala Gly Cys Gly Gly Cys Thr 
            1460                1465                1470        


Gly Thr Thr Gly Cys Cys Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys 
        1475                1480                1485            


Cys Ala Gly Gly Cys Cys Cys Ala Cys Gly Gly Cys Thr Thr Gly Ala 
    1490                1495                1500                


Cys Cys Cys Cys Gly Gly Ala Gly Cys Ala Gly Gly Thr Gly Gly Thr 
1505                1510                1515                1520


Gly Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Ala Ala Thr 
                1525                1530                1535    


Ala Thr Thr Gly Gly Thr Gly Gly Cys Ala Ala Gly Cys Ala Gly Gly 
            1540                1545                1550        


Cys Gly Cys Thr Gly Gly Ala Gly Ala Cys Gly Gly Thr Gly Cys Ala 
        1555                1560                1565            


Gly Gly Cys Gly Cys Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Gly 
    1570                1575                1580                


Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Cys Cys Cys Ala Cys Gly 
1585                1590                1595                1600


Gly Cys Thr Thr Gly Ala Cys Cys Cys Cys Cys Cys Ala Gly Cys Ala 
                1605                1610                1615    


Gly Gly Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr Cys Gly Cys Cys 
            1620                1625                1630        


Ala Gly Cys Ala Ala Thr Gly Gly Cys Gly Gly Thr Gly Gly Cys Ala 
        1635                1640                1645            


Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Gly Ala Cys 
    1650                1655                1660                


Gly Gly Thr Cys Cys Ala Gly Cys Gly Gly Cys Thr Gly Thr Thr Gly 
1665                1670                1675                1680


Cys Cys Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly 
                1685                1690                1695    


Cys Cys Cys Ala Cys Gly Gly Cys Thr Thr Gly Ala Cys Cys Cys Cys 
            1700                1705                1710        


Gly Gly Ala Gly Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly Cys Cys 
        1715                1720                1725            


Ala Thr Cys Gly Cys Cys Ala Gly Cys Ala Ala Thr Ala Thr Thr Gly 
    1730                1735                1740                


Gly Thr Gly Gly Cys Ala Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr 
1745                1750                1755                1760


Gly Gly Ala Gly Ala Cys Gly Gly Thr Gly Cys Ala Gly Gly Cys Gly 
                1765                1770                1775    


Cys Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Gly Cys Thr Gly Thr 
            1780                1785                1790        


Gly Cys Cys Ala Gly Gly Cys Cys Cys Ala Cys Gly Gly Cys Thr Thr 
        1795                1800                1805            


Gly Ala Cys Cys Cys Cys Cys Cys Ala Gly Cys Ala Gly Gly Thr Gly 
    1810                1815                1820                


Gly Thr Gly Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Ala 
1825                1830                1835                1840


Ala Thr Gly Gly Cys Gly Gly Thr Gly Gly Cys Ala Ala Gly Cys Ala 
                1845                1850                1855    


Gly Gly Cys Gly Cys Thr Gly Gly Ala Gly Ala Cys Gly Gly Thr Cys 
            1860                1865                1870        


Cys Ala Gly Cys Gly Gly Cys Thr Gly Thr Thr Gly Cys Cys Gly Gly 
        1875                1880                1885            


Thr Gly Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Cys Cys Cys Ala 
    1890                1895                1900                


Cys Gly Gly Cys Thr Thr Gly Ala Cys Cys Cys Cys Gly Gly Ala Gly 
1905                1910                1915                1920


Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr Cys Gly 
                1925                1930                1935    


Cys Cys Ala Gly Cys Cys Ala Cys Gly Ala Thr Gly Gly Cys Gly Gly 
            1940                1945                1950        


Cys Ala Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Gly 
        1955                1960                1965            


Ala Cys Gly Gly Thr Cys Cys Ala Gly Cys Gly Gly Cys Thr Gly Thr 
    1970                1975                1980                


Thr Gly Cys Cys Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys Cys Ala 
1985                1990                1995                2000


Gly Gly Cys Cys Cys Ala Cys Gly Gly Cys Thr Thr Gly Ala Cys Cys 
                2005                2010                2015    


Cys Cys Thr Cys Ala Gly Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly 
            2020                2025                2030        


Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Ala Ala Thr Gly Gly 
        2035                2040                2045            


Cys Gly Gly Cys Gly Gly Cys Ala Gly Gly Cys Cys Gly Gly Cys Gly 
    2050                2055                2060                


Cys Thr Gly Gly Ala Gly Ala Gly Cys Ala Thr Thr Gly Thr Thr Gly 
2065                2070                2075                2080


Cys Cys Cys Ala Gly Thr Thr Ala Thr Cys Thr Cys Gly Cys Cys Cys 
                2085                2090                2095    


Thr Gly Ala Thr Cys Cys Gly Gly Cys Gly Thr Thr Gly Gly Cys Cys 
            2100                2105                2110        


Gly Cys Gly Thr Thr Gly Ala Cys Cys Ala Ala Cys Gly Ala Cys Cys 
        2115                2120                2125            


Ala Cys Cys Thr Cys Gly Thr Cys Gly Cys Cys Thr Thr Gly Gly Cys 
    2130                2135                2140                


Cys Thr Gly Cys Cys Thr Cys Gly Gly Cys Gly Gly Gly Cys Gly Thr 
2145                2150                2155                2160


Cys Cys Thr Gly Cys Gly Cys Thr Gly Gly Ala Thr Gly Cys Ala Gly 
                2165                2170                2175    


Thr Gly Ala Ala Ala Ala Ala Gly Gly Gly Ala Thr Thr Gly Gly Gly 
            2180                2185                2190        


Gly Gly Ala Thr Cys Cys Thr Ala Thr Cys Ala Gly Cys Cys Gly Thr 
        2195                2200                2205            


Thr Cys Cys Cys Ala Gly Cys Thr Gly Gly Thr Gly Ala Ala Gly Thr 
    2210                2215                2220                


Cys Cys Gly Ala Gly Cys Thr Gly Gly Ala Gly Gly Ala Gly Ala Ala 
2225                2230                2235                2240


Gly Ala Ala Ala Thr Cys Cys Gly Ala Gly Thr Thr Gly Ala Gly Gly 
                2245                2250                2255    


Cys Ala Cys Ala Ala Gly Cys Thr Gly Ala Ala Gly Thr Ala Cys Gly 
            2260                2265                2270        


Thr Gly Cys Cys Cys Cys Ala Cys Gly Ala Gly Thr Ala Cys Ala Thr 
        2275                2280                2285            


Cys Gly Ala Gly Cys Thr Gly Ala Thr Cys Gly Ala Gly Ala Thr Cys 
    2290                2295                2300                


Gly Cys Cys Cys Gly Gly Ala Ala Cys Ala Gly Cys Ala Cys Cys Cys 
2305                2310                2315                2320


Ala Gly Gly Ala Cys Cys Gly Thr Ala Thr Cys Cys Thr Gly Gly Ala 
                2325                2330                2335    


Gly Ala Thr Gly Ala Ala Gly Gly Thr Gly Ala Thr Gly Gly Ala Gly 
            2340                2345                2350        


Thr Thr Cys Thr Thr Cys Ala Thr Gly Ala Ala Gly Gly Thr Gly Thr 
        2355                2360                2365            


Ala Cys Gly Gly Cys Thr Ala Cys Ala Gly Gly Gly Gly Cys Ala Ala 
    2370                2375                2380                


Gly Cys Ala Cys Cys Thr Gly Gly Gly Cys Gly Gly Cys Thr Cys Cys 
2385                2390                2395                2400


Ala Gly Gly Ala Ala Gly Cys Cys Cys Gly Ala Cys Gly Gly Cys Gly 
                2405                2410                2415    


Cys Cys Ala Thr Cys Thr Ala Cys Ala Cys Cys Gly Thr Gly Gly Gly 
            2420                2425                2430        


Cys Thr Cys Cys Cys Cys Cys Ala Thr Cys Gly Ala Cys Thr Ala Cys 
        2435                2440                2445            


Gly Gly Cys Gly Thr Gly Ala Thr Cys Gly Thr Gly Gly Ala Cys Ala 
    2450                2455                2460                


Cys Cys Ala Ala Gly Gly Cys Cys Thr Ala Cys Thr Cys Cys Gly Gly 
2465                2470                2475                2480


Cys Gly Gly Cys Thr Ala Cys Ala Ala Cys Cys Thr Gly Cys Cys Cys 
                2485                2490                2495    


Ala Thr Cys Gly Gly Cys Cys Ala Gly Gly Cys Cys Gly Ala Cys Gly 
            2500                2505                2510        


Ala Ala Ala Thr Gly Cys Ala Gly Ala Gly Gly Thr Ala Cys Gly Thr 
        2515                2520                2525            


Gly Gly Ala Gly Gly Ala Gly Ala Ala Cys Cys Ala Gly Ala Cys Cys 
    2530                2535                2540                


Ala Gly Gly Ala Ala Cys Ala Ala Gly Cys Ala Cys Ala Thr Cys Ala 
2545                2550                2555                2560


Ala Cys Cys Cys Cys Ala Ala Cys Gly Ala Gly Thr Gly Gly Thr Gly 
                2565                2570                2575    


Gly Ala Ala Gly Gly Thr Gly Thr Ala Cys Cys Cys Cys Thr Cys Cys 
            2580                2585                2590        


Ala Gly Cys Gly Thr Gly Ala Cys Cys Gly Ala Gly Thr Thr Cys Ala 
        2595                2600                2605            


Ala Gly Thr Thr Cys Cys Thr Gly Thr Thr Cys Gly Thr Gly Thr Cys 
    2610                2615                2620                


Cys Gly Gly Cys Cys Ala Cys Thr Thr Cys Ala Ala Gly Gly Gly Cys 
2625                2630                2635                2640


Ala Ala Cys Thr Ala Cys Ala Ala Gly Gly Cys Cys Cys Ala Gly Cys 
                2645                2650                2655    


Thr Gly Ala Cys Cys Ala Gly Gly Cys Thr Gly Ala Ala Cys Cys Ala 
            2660                2665                2670        


Cys Ala Thr Cys Ala Cys Cys Ala Ala Cys Thr Gly Cys Ala Ala Cys 
        2675                2680                2685            


Gly Gly Cys Gly Cys Cys Gly Thr Gly Cys Thr Gly Thr Cys Cys Gly 
    2690                2695                2700                


Thr Gly Gly Ala Gly Gly Ala Gly Cys Thr Cys Cys Thr Gly Ala Thr 
2705                2710                2715                2720


Cys Gly Gly Cys Gly Gly Cys Gly Ala Gly Ala Thr Gly Ala Thr Cys 
                2725                2730                2735    


Ala Ala Gly Gly Cys Cys Gly Gly Cys Ala Cys Cys Cys Thr Gly Ala 
            2740                2745                2750        


Cys Cys Cys Thr Gly Gly Ala Gly Gly Ala Gly Gly Thr Gly Ala Gly 
        2755                2760                2765            


Gly Ala Gly Gly Ala Ala Gly Thr Thr Cys Ala Ala Cys Ala Ala Cys 
    2770                2775                2780                


Gly Gly Cys Gly Ala Gly Ala Thr Cys Ala Ala Cys Thr Thr Cys Gly 
2785                2790                2795                2800


Cys Gly Gly Cys Cys Gly Ala Cys Thr Gly Ala Thr Ala Ala 
                2805                2810                


<210>  53

<211>  2832
<212>  PRT
<213>  Artificial sequence

<220>
<223>  polynucleotide encoding TRAC_T01-R TALEN

<400>  53
Ala Thr Gly Gly Gly Cys Gly Ala Thr Cys Cys Thr Ala Ala Ala Ala 
1               5                   10                  15      


Ala Gly Ala Ala Ala Cys Gly Thr Ala Ala Gly Gly Thr Cys Ala Thr 
            20                  25                  30          


Cys Gly Ala Thr Ala Ala Gly Gly Ala Gly Ala Cys Cys Gly Cys Cys 
        35                  40                  45              


Gly Cys Thr Gly Cys Cys Ala Ala Gly Thr Thr Cys Gly Ala Gly Ala 
    50                  55                  60                  


Gly Ala Cys Ala Gly Cys Ala Cys Ala Thr Gly Gly Ala Cys Ala Gly 
65                  70                  75                  80  


Cys Ala Thr Cys Gly Ala Thr Ala Thr Cys Gly Cys Cys Gly Ala Thr 
                85                  90                  95      


Cys Thr Ala Cys Gly Cys Ala Cys Gly Cys Thr Cys Gly Gly Cys Thr 
            100                 105                 110         


Ala Cys Ala Gly Cys Cys Ala Gly Cys Ala Gly Cys Ala Ala Cys Ala 
        115                 120                 125             


Gly Gly Ala Gly Ala Ala Gly Ala Thr Cys Ala Ala Ala Cys Cys Gly 
    130                 135                 140                 


Ala Ala Gly Gly Thr Thr Cys Gly Thr Thr Cys Gly Ala Cys Ala Gly 
145                 150                 155                 160 


Thr Gly Gly Cys Gly Cys Ala Gly Cys Ala Cys Cys Ala Cys Gly Ala 
                165                 170                 175     


Gly Gly Cys Ala Cys Thr Gly Gly Thr Cys Gly Gly Cys Cys Ala Cys 
            180                 185                 190         


Gly Gly Gly Thr Thr Thr Ala Cys Ala Cys Ala Cys Gly Cys Gly Cys 
        195                 200                 205             


Ala Cys Ala Thr Cys Gly Thr Thr Gly Cys Gly Thr Thr Ala Ala Gly 
    210                 215                 220                 


Cys Cys Ala Ala Cys Ala Cys Cys Cys Gly Gly Cys Ala Gly Cys Gly 
225                 230                 235                 240 


Thr Thr Ala Gly Gly Gly Ala Cys Cys Gly Thr Cys Gly Cys Thr Gly 
                245                 250                 255     


Thr Cys Ala Ala Gly Thr Ala Thr Cys Ala Gly Gly Ala Cys Ala Thr 
            260                 265                 270         


Gly Ala Thr Cys Gly Cys Ala Gly Cys Gly Thr Thr Gly Cys Cys Ala 
        275                 280                 285             


Gly Ala Gly Gly Cys Gly Ala Cys Ala Cys Ala Cys Gly Ala Ala Gly 
    290                 295                 300                 


Cys Gly Ala Thr Cys Gly Thr Thr Gly Gly Cys Gly Thr Cys Gly Gly 
305                 310                 315                 320 


Cys Ala Ala Ala Cys Ala Gly Thr Gly Gly Thr Cys Cys Gly Gly Cys 
                325                 330                 335     


Gly Cys Ala Cys Gly Cys Gly Cys Thr Cys Thr Gly Gly Ala Gly Gly 
            340                 345                 350         


Cys Cys Thr Thr Gly Cys Thr Cys Ala Cys Gly Gly Thr Gly Gly Cys 
        355                 360                 365             


Gly Gly Gly Ala Gly Ala Gly Thr Thr Gly Ala Gly Ala Gly Gly Thr 
    370                 375                 380                 


Cys Cys Ala Cys Cys Gly Thr Thr Ala Cys Ala Gly Thr Thr Gly Gly 
385                 390                 395                 400 


Ala Cys Ala Cys Ala Gly Gly Cys Cys Ala Ala Cys Thr Thr Cys Thr 
                405                 410                 415     


Cys Ala Ala Gly Ala Thr Thr Gly Cys Ala Ala Ala Ala Cys Gly Thr 
            420                 425                 430         


Gly Gly Cys Gly Gly Cys Gly Thr Gly Ala Cys Cys Gly Cys Ala Gly 
        435                 440                 445             


Thr Gly Gly Ala Gly Gly Cys Ala Gly Thr Gly Cys Ala Thr Gly Cys 
    450                 455                 460                 


Ala Thr Gly Gly Cys Gly Cys Ala Ala Thr Gly Cys Ala Cys Thr Gly 
465                 470                 475                 480 


Ala Cys Gly Gly Gly Thr Gly Cys Cys Cys Cys Gly Cys Thr Cys Ala 
                485                 490                 495     


Ala Cys Thr Thr Gly Ala Cys Cys Cys Cys Gly Gly Ala Gly Cys Ala 
            500                 505                 510         


Gly Gly Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr Cys Gly Cys Cys 
        515                 520                 525             


Ala Gly Cys Cys Ala Cys Gly Ala Thr Gly Gly Cys Gly Gly Cys Ala 
    530                 535                 540                 


Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Gly Ala Cys 
545                 550                 555                 560 


Gly Gly Thr Cys Cys Ala Gly Cys Gly Gly Cys Thr Gly Thr Thr Gly 
                565                 570                 575     


Cys Cys Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly 
            580                 585                 590         


Cys Cys Cys Ala Cys Gly Gly Cys Thr Thr Gly Ala Cys Cys Cys Cys 
        595                 600                 605             


Cys Cys Ala Gly Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly Cys Cys 
    610                 615                 620                 


Ala Thr Cys Gly Cys Cys Ala Gly Cys Ala Ala Thr Gly Gly Cys Gly 
625                 630                 635                 640 


Gly Thr Gly Gly Cys Ala Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr 
                645                 650                 655     


Gly Gly Ala Gly Ala Cys Gly Gly Thr Cys Cys Ala Gly Cys Gly Gly 
            660                 665                 670         


Cys Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Gly Cys Thr Gly Thr 
        675                 680                 685             


Gly Cys Cys Ala Gly Gly Cys Cys Cys Ala Cys Gly Gly Cys Thr Thr 
    690                 695                 700                 


Gly Ala Cys Cys Cys Cys Gly Gly Ala Gly Cys Ala Gly Gly Thr Gly 
705                 710                 715                 720 


Gly Thr Gly Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Cys 
                725                 730                 735     


Ala Cys Gly Ala Thr Gly Gly Cys Gly Gly Cys Ala Ala Gly Cys Ala 
            740                 745                 750         


Gly Gly Cys Gly Cys Thr Gly Gly Ala Gly Ala Cys Gly Gly Thr Cys 
        755                 760                 765             


Cys Ala Gly Cys Gly Gly Cys Thr Gly Thr Thr Gly Cys Cys Gly Gly 
    770                 775                 780                 


Thr Gly Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Cys Cys Cys Ala 
785                 790                 795                 800 


Cys Gly Gly Cys Thr Thr Gly Ala Cys Cys Cys Cys Gly Gly Ala Gly 
                805                 810                 815     


Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr Cys Gly 
            820                 825                 830         


Cys Cys Ala Gly Cys Ala Ala Thr Ala Thr Thr Gly Gly Thr Gly Gly 
        835                 840                 845             


Cys Ala Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Gly 
    850                 855                 860                 


Ala Cys Gly Gly Thr Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly Thr 
865                 870                 875                 880 


Thr Gly Cys Cys Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys Cys Ala 
                885                 890                 895     


Gly Gly Cys Cys Cys Ala Cys Gly Gly Cys Thr Thr Gly Ala Cys Cys 
            900                 905                 910         


Cys Cys Cys Cys Ala Gly Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly 
        915                 920                 925             


Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Ala Ala Thr Ala Ala 
    930                 935                 940                 


Thr Gly Gly Thr Gly Gly Cys Ala Ala Gly Cys Ala Gly Gly Cys Gly 
945                 950                 955                 960 


Cys Thr Gly Gly Ala Gly Ala Cys Gly Gly Thr Cys Cys Ala Gly Cys 
                965                 970                 975     


Gly Gly Cys Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Gly Cys Thr 
            980                 985                 990         


Gly Thr Gly Cys Cys Ala Gly Gly Cys Cys Cys Ala Cys Gly Gly Cys 
        995                 1000                1005            


Thr Thr Gly Ala Cys Cys Cys Cys Gly Gly Ala Gly Cys Ala Gly Gly 
    1010                1015                1020                


Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly 
1025                1030                1035                1040


Cys Cys Ala Cys Gly Ala Thr Gly Gly Cys Gly Gly Cys Ala Ala Gly 
                1045                1050                1055    


Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Gly Ala Cys Gly Gly 
            1060                1065                1070        


Thr Cys Cys Ala Gly Cys Gly Gly Cys Thr Gly Thr Thr Gly Cys Cys 
        1075                1080                1085            


Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Cys Cys 
    1090                1095                1100                


Cys Ala Cys Gly Gly Cys Thr Thr Gly Ala Cys Cys Cys Cys Cys Cys 
1105                1110                1115                1120


Ala Gly Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr 
                1125                1130                1135    


Cys Gly Cys Cys Ala Gly Cys Ala Ala Thr Gly Gly Cys Gly Gly Thr 
            1140                1145                1150        


Gly Gly Cys Ala Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly 
        1155                1160                1165            


Ala Gly Ala Cys Gly Gly Thr Cys Cys Ala Gly Cys Gly Gly Cys Thr 
    1170                1175                1180                


Gly Thr Thr Gly Cys Cys Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys 
1185                1190                1195                1200


Cys Ala Gly Gly Cys Cys Cys Ala Cys Gly Gly Cys Thr Thr Gly Ala 
                1205                1210                1215    


Cys Cys Cys Cys Cys Cys Ala Gly Cys Ala Gly Gly Thr Gly Gly Thr 
            1220                1225                1230        


Gly Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Ala Ala Thr 
        1235                1240                1245            


Ala Ala Thr Gly Gly Thr Gly Gly Cys Ala Ala Gly Cys Ala Gly Gly 
    1250                1255                1260                


Cys Gly Cys Thr Gly Gly Ala Gly Ala Cys Gly Gly Thr Cys Cys Ala 
1265                1270                1275                1280


Gly Cys Gly Gly Cys Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Gly 
                1285                1290                1295    


Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Cys Cys Cys Ala Cys Gly 
            1300                1305                1310        


Gly Cys Thr Thr Gly Ala Cys Cys Cys Cys Cys Cys Ala Gly Cys Ala 
        1315                1320                1325            


Gly Gly Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr Cys Gly Cys Cys 
    1330                1335                1340                


Ala Gly Cys Ala Ala Thr Ala Ala Thr Gly Gly Thr Gly Gly Cys Ala 
1345                1350                1355                1360


Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Gly Ala Cys 
                1365                1370                1375    


Gly Gly Thr Cys Cys Ala Gly Cys Gly Gly Cys Thr Gly Thr Thr Gly 
            1380                1385                1390        


Cys Cys Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly 
        1395                1400                1405            


Cys Cys Cys Ala Cys Gly Gly Cys Thr Thr Gly Ala Cys Cys Cys Cys 
    1410                1415                1420                


Cys Cys Ala Gly Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly Cys Cys 
1425                1430                1435                1440


Ala Thr Cys Gly Cys Cys Ala Gly Cys Ala Ala Thr Gly Gly Cys Gly 
                1445                1450                1455    


Gly Thr Gly Gly Cys Ala Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr 
            1460                1465                1470        


Gly Gly Ala Gly Ala Cys Gly Gly Thr Cys Cys Ala Gly Cys Gly Gly 
        1475                1480                1485            


Cys Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Gly Cys Thr Gly Thr 
    1490                1495                1500                


Gly Cys Cys Ala Gly Gly Cys Cys Cys Ala Cys Gly Gly Cys Thr Thr 
1505                1510                1515                1520


Gly Ala Cys Cys Cys Cys Gly Gly Ala Gly Cys Ala Gly Gly Thr Gly 
                1525                1530                1535    


Gly Thr Gly Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Ala 
            1540                1545                1550        


Ala Thr Ala Thr Thr Gly Gly Thr Gly Gly Cys Ala Ala Gly Cys Ala 
        1555                1560                1565            


Gly Gly Cys Gly Cys Thr Gly Gly Ala Gly Ala Cys Gly Gly Thr Gly 
    1570                1575                1580                


Cys Ala Gly Gly Cys Gly Cys Thr Gly Thr Thr Gly Cys Cys Gly Gly 
1585                1590                1595                1600


Thr Gly Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Cys Cys Cys Ala 
                1605                1610                1615    


Cys Gly Gly Cys Thr Thr Gly Ala Cys Cys Cys Cys Gly Gly Ala Gly 
            1620                1625                1630        


Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr Cys Gly 
        1635                1640                1645            


Cys Cys Ala Gly Cys Cys Ala Cys Gly Ala Thr Gly Gly Cys Gly Gly 
    1650                1655                1660                


Cys Ala Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Gly 
1665                1670                1675                1680


Ala Cys Gly Gly Thr Cys Cys Ala Gly Cys Gly Gly Cys Thr Gly Thr 
                1685                1690                1695    


Thr Gly Cys Cys Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys Cys Ala 
            1700                1705                1710        


Gly Gly Cys Cys Cys Ala Cys Gly Gly Cys Thr Thr Gly Ala Cys Cys 
        1715                1720                1725            


Cys Cys Gly Gly Ala Gly Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly 
    1730                1735                1740                


Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Ala Ala Thr Ala Thr 
1745                1750                1755                1760


Thr Gly Gly Thr Gly Gly Cys Ala Ala Gly Cys Ala Gly Gly Cys Gly 
                1765                1770                1775    


Cys Thr Gly Gly Ala Gly Ala Cys Gly Gly Thr Gly Cys Ala Gly Gly 
            1780                1785                1790        


Cys Gly Cys Thr Gly Thr Thr Gly Cys Cys Gly Gly Thr Gly Cys Thr 
        1795                1800                1805            


Gly Thr Gly Cys Cys Ala Gly Gly Cys Cys Cys Ala Cys Gly Gly Cys 
    1810                1815                1820                


Thr Thr Gly Ala Cys Cys Cys Cys Gly Gly Ala Gly Cys Ala Gly Gly 
1825                1830                1835                1840


Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly 
                1845                1850                1855    


Cys Cys Ala Cys Gly Ala Thr Gly Gly Cys Gly Gly Cys Ala Ala Gly 
            1860                1865                1870        


Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly Ala Gly Ala Cys Gly Gly 
        1875                1880                1885            


Thr Cys Cys Ala Gly Cys Gly Gly Cys Thr Gly Thr Thr Gly Cys Cys 
    1890                1895                1900                


Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys Cys Ala Gly Gly Cys Cys 
1905                1910                1915                1920


Cys Ala Cys Gly Gly Cys Thr Thr Gly Ala Cys Cys Cys Cys Cys Cys 
                1925                1930                1935    


Ala Gly Cys Ala Gly Gly Thr Gly Gly Thr Gly Gly Cys Cys Ala Thr 
            1940                1945                1950        


Cys Gly Cys Cys Ala Gly Cys Ala Ala Thr Ala Ala Thr Gly Gly Thr 
        1955                1960                1965            


Gly Gly Cys Ala Ala Gly Cys Ala Gly Gly Cys Gly Cys Thr Gly Gly 
    1970                1975                1980                


Ala Gly Ala Cys Gly Gly Thr Cys Cys Ala Gly Cys Gly Gly Cys Thr 
1985                1990                1995                2000


Gly Thr Thr Gly Cys Cys Gly Gly Thr Gly Cys Thr Gly Thr Gly Cys 
                2005                2010                2015    


Cys Ala Gly Gly Cys Cys Cys Ala Cys Gly Gly Cys Thr Thr Gly Ala 
            2020                2025                2030        


Cys Cys Cys Cys Thr Cys Ala Gly Cys Ala Gly Gly Thr Gly Gly Thr 
        2035                2040                2045            


Gly Gly Cys Cys Ala Thr Cys Gly Cys Cys Ala Gly Cys Ala Ala Thr 
    2050                2055                2060                


Gly Gly Cys Gly Gly Cys Gly Gly Cys Ala Gly Gly Cys Cys Gly Gly 
2065                2070                2075                2080


Cys Gly Cys Thr Gly Gly Ala Gly Ala Gly Cys Ala Thr Thr Gly Thr 
                2085                2090                2095    


Thr Gly Cys Cys Cys Ala Gly Thr Thr Ala Thr Cys Thr Cys Gly Cys 
            2100                2105                2110        


Cys Cys Thr Gly Ala Thr Cys Cys Gly Gly Cys Gly Thr Thr Gly Gly 
        2115                2120                2125            


Cys Cys Gly Cys Gly Thr Thr Gly Ala Cys Cys Ala Ala Cys Gly Ala 
    2130                2135                2140                


Cys Cys Ala Cys Cys Thr Cys Gly Thr Cys Gly Cys Cys Thr Thr Gly 
2145                2150                2155                2160


Gly Cys Cys Thr Gly Cys Cys Thr Cys Gly Gly Cys Gly Gly Gly Cys 
                2165                2170                2175    


Gly Thr Cys Cys Thr Gly Cys Gly Cys Thr Gly Gly Ala Thr Gly Cys 
            2180                2185                2190        


Ala Gly Thr Gly Ala Ala Ala Ala Ala Gly Gly Gly Ala Thr Thr Gly 
        2195                2200                2205            


Gly Gly Gly Gly Ala Thr Cys Cys Thr Ala Thr Cys Ala Gly Cys Cys 
    2210                2215                2220                


Gly Thr Thr Cys Cys Cys Ala Gly Cys Thr Gly Gly Thr Gly Ala Ala 
2225                2230                2235                2240


Gly Thr Cys Cys Gly Ala Gly Cys Thr Gly Gly Ala Gly Gly Ala Gly 
                2245                2250                2255    


Ala Ala Gly Ala Ala Ala Thr Cys Cys Gly Ala Gly Thr Thr Gly Ala 
            2260                2265                2270        


Gly Gly Cys Ala Cys Ala Ala Gly Cys Thr Gly Ala Ala Gly Thr Ala 
        2275                2280                2285            


Cys Gly Thr Gly Cys Cys Cys Cys Ala Cys Gly Ala Gly Thr Ala Cys 
    2290                2295                2300                


Ala Thr Cys Gly Ala Gly Cys Thr Gly Ala Thr Cys Gly Ala Gly Ala 
2305                2310                2315                2320


Thr Cys Gly Cys Cys Cys Gly Gly Ala Ala Cys Ala Gly Cys Ala Cys 
                2325                2330                2335    


Cys Cys Ala Gly Gly Ala Cys Cys Gly Thr Ala Thr Cys Cys Thr Gly 
            2340                2345                2350        


Gly Ala Gly Ala Thr Gly Ala Ala Gly Gly Thr Gly Ala Thr Gly Gly 
        2355                2360                2365            


Ala Gly Thr Thr Cys Thr Thr Cys Ala Thr Gly Ala Ala Gly Gly Thr 
    2370                2375                2380                


Gly Thr Ala Cys Gly Gly Cys Thr Ala Cys Ala Gly Gly Gly Gly Cys 
2385                2390                2395                2400


Ala Ala Gly Cys Ala Cys Cys Thr Gly Gly Gly Cys Gly Gly Cys Thr 
                2405                2410                2415    


Cys Cys Ala Gly Gly Ala Ala Gly Cys Cys Cys Gly Ala Cys Gly Gly 
            2420                2425                2430        


Cys Gly Cys Cys Ala Thr Cys Thr Ala Cys Ala Cys Cys Gly Thr Gly 
        2435                2440                2445            


Gly Gly Cys Thr Cys Cys Cys Cys Cys Ala Thr Cys Gly Ala Cys Thr 
    2450                2455                2460                


Ala Cys Gly Gly Cys Gly Thr Gly Ala Thr Cys Gly Thr Gly Gly Ala 
2465                2470                2475                2480


Cys Ala Cys Cys Ala Ala Gly Gly Cys Cys Thr Ala Cys Thr Cys Cys 
                2485                2490                2495    


Gly Gly Cys Gly Gly Cys Thr Ala Cys Ala Ala Cys Cys Thr Gly Cys 
            2500                2505                2510        


Cys Cys Ala Thr Cys Gly Gly Cys Cys Ala Gly Gly Cys Cys Gly Ala 
        2515                2520                2525            


Cys Gly Ala Ala Ala Thr Gly Cys Ala Gly Ala Gly Gly Thr Ala Cys 
    2530                2535                2540                


Gly Thr Gly Gly Ala Gly Gly Ala Gly Ala Ala Cys Cys Ala Gly Ala 
2545                2550                2555                2560


Cys Cys Ala Gly Gly Ala Ala Cys Ala Ala Gly Cys Ala Cys Ala Thr 
                2565                2570                2575    


Cys Ala Ala Cys Cys Cys Cys Ala Ala Cys Gly Ala Gly Thr Gly Gly 
            2580                2585                2590        


Thr Gly Gly Ala Ala Gly Gly Thr Gly Thr Ala Cys Cys Cys Cys Thr 
        2595                2600                2605            


Cys Cys Ala Gly Cys Gly Thr Gly Ala Cys Cys Gly Ala Gly Thr Thr 
    2610                2615                2620                


Cys Ala Ala Gly Thr Thr Cys Cys Thr Gly Thr Thr Cys Gly Thr Gly 
2625                2630                2635                2640


Thr Cys Cys Gly Gly Cys Cys Ala Cys Thr Thr Cys Ala Ala Gly Gly 
                2645                2650                2655    


Gly Cys Ala Ala Cys Thr Ala Cys Ala Ala Gly Gly Cys Cys Cys Ala 
            2660                2665                2670        


Gly Cys Thr Gly Ala Cys Cys Ala Gly Gly Cys Thr Gly Ala Ala Cys 
        2675                2680                2685            


Cys Ala Cys Ala Thr Cys Ala Cys Cys Ala Ala Cys Thr Gly Cys Ala 
    2690                2695                2700                


Ala Cys Gly Gly Cys Gly Cys Cys Gly Thr Gly Cys Thr Gly Thr Cys 
2705                2710                2715                2720


Cys Gly Thr Gly Gly Ala Gly Gly Ala Gly Cys Thr Cys Cys Thr Gly 
                2725                2730                2735    


Ala Thr Cys Gly Gly Cys Gly Gly Cys Gly Ala Gly Ala Thr Gly Ala 
            2740                2745                2750        


Thr Cys Ala Ala Gly Gly Cys Cys Gly Gly Cys Ala Cys Cys Cys Thr 
        2755                2760                2765            


Gly Ala Cys Cys Cys Thr Gly Gly Ala Gly Gly Ala Gly Gly Thr Gly 
    2770                2775                2780                


Ala Gly Gly Ala Gly Gly Ala Ala Gly Thr Thr Cys Ala Ala Cys Ala 
2785                2790                2795                2800


Ala Cys Gly Gly Cys Gly Ala Gly Ala Thr Cys Ala Ala Cys Thr Thr 
                2805                2810                2815    


Cys Gly Cys Gly Gly Cys Cys Gly Ala Cys Thr Gly Ala Thr Ala Ala 
            2820                2825                2830        






<210>  54

<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized scFv Klon43 Variant VL1

<400>  54
Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser Pro Ser Ser Val 
1               5                   10                  15      


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
            20                  25                  30          


Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  55

<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized scFv Klon43 Variant VL2

<400>  55
Met Ala Asp Tyr Lys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val 
1               5                   10                  15      


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
            20                  25                  30          


Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Arg Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  56

<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized scFv Klon43 Variant VL3

<400>  56
Met Ala Asp Tyr Lys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val 
1               5                   10                  15      


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
            20                  25                  30          


Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  57

<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized scFv Klon43 Variant VL4

<400>  57
Met Ala Asp Tyr Lys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val 
1               5                   10                  15      


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
            20                  25                  30          


Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  58

<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized scFv Klon43 Variant VL5

<400>  58
Met Ala Asp Tyr Lys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val 
1               5                   10                  15      


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
            20                  25                  30          


Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Arg Gln Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  59

<211>  113
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized scFv Klon43 Variant VL6

<400>  59
Met Ala Asp Tyr Lys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val 
1               5                   10                  15      


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
            20                  25                  30          


Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Tyr Gly Gln Ser Gly Val Pro 
    50                  55                  60                  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr 
                85                  90                  95      


Tyr Ser Thr Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  60

<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized scFv Klon43 variant VH1

<400>  60
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  61

<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized scFv Klon43 variant VH2

<400>  61
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  62

<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized scFv Klon43 variant VH3

<400>  62
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  63

<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized scFv Klon43 variant VH4

<400>  63
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ser Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  64

<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized scFv Klon43 variant VH5

<400>  64
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  65

<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized scFv Klon43 variant VH6

<400>  65
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  66

<211>  127
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Humanized scFv Klon43 variant VH7

<400>  66
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Phe Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly 
            100                 105                 110         


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  67

<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR1

<400>  67
Gly Phe Thr Phe Thr Asp Tyr Tyr 
1               5               


<210>  68

<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR2

<400>  68
Arg Ser Lys Ala Asp Gly Tyr Thr Thr 
1               5                   


<210>  69

<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR3

<400>  69
Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr Tyr Ser Pro Glu Gly Ala Met 
1               5                   10                  15      


Asp Tyr 
        


<210>  70

<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR4

<400>  70
Gln Asn Val Asp Ser Ala 
1               5       


<210>  71

<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR5

<400>  71
Ser Ala Ser 
1           


<210>  72

<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  CDR6

<400>  72
Gln Gln Tyr Tyr Ser Thr Pro Trp Thr 
1               5                   


<210>  73

<211>  117
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hVH Klo43-3 generic

<400>  73
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Ile Arg Ser Lys Ala Asp Gly Tyr Thr Thr Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Arg Asp Ala Ala Tyr Tyr Ser 
                85                  90                  95      


Tyr Tyr Ser Pro Glu Gly Ala Met Asp Tyr Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa 
        115         


<210>  74

<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  hVL Klo43-3 generic

<400>  74
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln 
            20                  25                  30          


Asn Val Asp Ser Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Ser Ala Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Gln Tyr 
                85                  90                  95      


Tyr Ser Thr Pro Trp Thr Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110     

<210>  75

<211>  470
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Klo43-1+SP

<400>  75
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr 
65                  70                  75                  80  


Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp 
                85                  90                  95      


Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu 
            100                 105                 110         


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr 
        115                 120                 125             


Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His 
                165                 170                 175     


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
    210                 215                 220                 


Gly Val Pro Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
                245                 250                 255     


Gln Gln Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Arg Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro 
        275                 280                 285             


Pro Gly Tyr Gln Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly 
    290                 295                 300                 


Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg 
305                 310                 315                 320 


Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln 
                325                 330                 335     


Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu 
            340                 345                 350         


Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala 
        355                 360                 365             


Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu 
    370                 375                 380                 


Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp 
385                 390                 395                 400 


Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu 
                405                 410                 415     


Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile 
            420                 425                 430         


Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr 
        435                 440                 445             


Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met 
    450                 455                 460                 


Gln Ala Leu Pro Pro Arg 
465                 470 


<210>  76

<211>  499
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Klo43-3+SP

<400>  76
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr 
65                  70                  75                  80  


Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp 
                85                  90                  95      


Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu 
            100                 105                 110         


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr 
        115                 120                 125             


Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His 
                165                 170                 175     


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
    210                 215                 220                 


Gly Val Pro Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
                245                 250                 255     


Gln Gln Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Arg Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala 
        275                 280                 285             


Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg 
    290                 295                 300                 


Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys 
305                 310                 315                 320 


Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu 
                325                 330                 335     


Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu 
            340                 345                 350         


Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln 
        355                 360                 365             


Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly 
    370                 375                 380                 


Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
385                 390                 395                 400 


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
                405                 410                 415     


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
            420                 425                 430         


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
        435                 440                 445             


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
    450                 455                 460                 


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
465                 470                 475                 480 


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
                485                 490                 495     


Pro Pro Arg 
            


<210>  77

<211>  685
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Klo43-5+SP

<400>  77
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Ser Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Thr Asp Tyr Tyr Met Ser Trp Val Arg Gln Pro Pro Gly Lys 
    50                  55                  60                  


Ala Leu Glu Trp Leu Ala Leu Ile Arg Ser Lys Ala Asp Gly Tyr Thr 
65                  70                  75                  80  


Thr Glu Tyr Ser Ala Ser Val Lys Gly Arg Phe Thr Leu Ser Arg Asp 
                85                  90                  95      


Asp Ser Gln Ser Ile Leu Tyr Leu Gln Met Asn Ala Leu Arg Pro Glu 
            100                 105                 110         


Asp Ser Ala Thr Tyr Tyr Cys Ala Arg Asp Ala Ala Tyr Tyr Ser Tyr 
        115                 120                 125             


Tyr Ser Pro Glu Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
    130                 135                 140                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Met Ala Asp Tyr Lys Asp Ile Val Met Thr Gln Ser His 
                165                 170                 175     


Lys Phe Met Ser Thr Ser Val Gly Asp Arg Val Asn Ile Thr Cys Lys 
            180                 185                 190         


Ala Ser Gln Asn Val Asp Ser Ala Val Ala Trp Tyr Gln Gln Lys Pro 
        195                 200                 205             


Gly Gln Ser Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser 
    210                 215                 220                 


Gly Val Pro Asp Arg Phe Thr Gly Arg Gly Ser Gly Thr Asp Phe Thr 
225                 230                 235                 240 


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
                245                 250                 255     


Gln Gln Tyr Tyr Ser Thr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
            260                 265                 270         


Glu Ile Lys Arg Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro 
        275                 280                 285             


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
    290                 295                 300                 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ala Arg Thr Pro Glu Val Thr 
305                 310                 315                 320 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
                325                 330                 335     


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            340                 345                 350         


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
        355                 360                 365             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    370                 375                 380                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
385                 390                 395                 400 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
                405                 410                 415     


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            420                 425                 430         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        435                 440                 445             


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    450                 455                 460                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
465                 470                 475                 480 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                485                 490                 495     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Ile Tyr Ile Trp Ala 
            500                 505                 510         


Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr 
        515                 520                 525             


Leu Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln 
    530                 535                 540                 


Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser 
545                 550                 555                 560 


Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys 
                565                 570                 575     


Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln 
            580                 585                 590         


Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu 
        595                 600                 605             


Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg 
    610                 615                 620                 


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
625                 630                 635                 640 


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
                645                 650                 655     


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
            660                 665                 670         


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        675                 680                 685 



