                         SEQUENCE LISTING

<110>  Capon, Daniel J.
 
<120>  HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE

<130>  0893/86150-PCT/JPW/REB/PEA

<150>  61/953,650
<151>  2014-03-14

<160>  203   

<170>  PatentIn version 3.5

<210>  1
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc domain having the N-terminal sequence 
       CDKTHTCPPCPAPE

<400>  1

Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
1               5                   10                  15      


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            20                  25                  30          


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        35                  40                  45              


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    50                  55                  60                  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
65                  70                  75                  80  


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                85                  90                  95      


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            100                 105                 110         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        115                 120                 125             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    130                 135                 140                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
145                 150                 155                 160 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                165                 170                 175     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            180                 185                 190         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        195                 200                 205             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    210                 215                 220                 


Ser Pro Gly Lys 
225             


<210>  2
<211>  684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human IgG1 Fc domain having the N-terminal sequence 
       CDKTHTCPPCPAPE

<400>  2
tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctg aactcctggg ggggccctca       60

gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc      120

acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg      180

gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg      240

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac      300

aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc      360

aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc      420

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg      480

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac      540

tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag      600

gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag      660

agcctctccc tgtctccggg taaa                                             684


<210>  3
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having SHH signal peptide

<400>  3

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Asp Lys Thr His Thr Cys Pro Pro 
            20                  25                  30          


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        35                  40                  45              


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    50                  55                  60                  


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
65                  70                  75                  80  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                85                  90                  95      


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            100                 105                 110         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        115                 120                 125             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    130                 135                 140                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
145                 150                 155                 160 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                165                 170                 175     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            180                 185                 190         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        195                 200                 205             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    210                 215                 220                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
225                 230                 235                 240 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250     


<210>  4
<211>  785
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having SHH signal 
       peptide

<400>  4
aagcttgaat tcccaccatg ctgctgctgg cgagatgtct gctgctagtc ctcgtctcct       60

cgctgctggt atgctcggga ctggcgtgtg acaaaactca cacatgccca ccgtgcccag      120

cacctgaact cctggggggg ccctcagtct tcctcttccc cccaaaaccc aaggacaccc      180

tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc      240

ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc aagacaaagc      300

cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc      360

aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc ctcccagccc      420

ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag gtgtacaccc      480

tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc ctggtcaaag      540

gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg gagaacaact      600

acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac agcaagctca      660

ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg atgcatgagg      720

ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa tgactcgagc      780

ggccg                                                                  785


<210>  5
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having IFN signal peptide

<400>  5

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Lys Thr His Thr Cys Pro Pro 
            20                  25                  30          


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        35                  40                  45              


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    50                  55                  60                  


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
65                  70                  75                  80  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                85                  90                  95      


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            100                 105                 110         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        115                 120                 125             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    130                 135                 140                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
145                 150                 155                 160 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                165                 170                 175     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            180                 185                 190         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        195                 200                 205             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    210                 215                 220                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
225                 230                 235                 240 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250     


<210>  6
<211>  785
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having IFN signal 
       peptide

<400>  6
aagcttgaat tcccaccatg gccttgacct ttgctttact ggtggccctc ctggtgctca       60

gctgcaagtc aagctgctct gtgggctgtg acaaaactca cacatgccca ccgtgcccag      120

cacctgaact cctggggggg ccctcagtct tcctcttccc cccaaaaccc aaggacaccc      180

tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc      240

ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc aagacaaagc      300

cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc      360

aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc ctcccagccc      420

ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag gtgtacaccc      480

tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc ctggtcaaag      540

gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg gagaacaact      600

acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac agcaagctca      660

ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg atgcatgagg      720

ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa tgactcgagc      780

ggccg                                                                  785


<210>  7
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having CETP signal peptide

<400>  7

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            20                  25                  30          


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                85                  90                  95      


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        115                 120                 125             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Pro Gly Lys 
                245 


<210>  8
<211>  767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having CETP signal 
       peptide

<400>  8
aagcttgaat tcccaccatg ctggctgcca cagtcctgac cctggccctg ctgggcaatg       60

cccatgcctg tgacaaaact cacacatgcc caccgtgccc agcacctgaa ctcctggggg      120

ggccctcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc tcccggaccc      180

ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc aagttcaact      240

ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag gagcagtaca      300

acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg ctgaatggca      360

aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag aaaaccatct      420

ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca tcccgggatg      480

agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat cccagcgaca      540

tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc acgcctcccg      600

tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac aagagcaggt      660

ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac aaccactaca      720

cgcagaagag cctctccctg tctccgggta aatgactcga gcggccg                    767


<210>  9
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc domain having the N-terminal sequence CPPCPAPE

<400>  9

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220         


<210>  10
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human IgG1 Fc domain having the N-terminal sequence 
       CPPCPAPE

<400>  10
tgcccaccgt gcccagcacc tgaactcctg ggggggccct cagtcttcct cttcccccca       60

aaacccaagg acaccctcat gatctcccgg acccctgagg tcacatgcgt ggtggtggac      120

gtgagccacg aagaccctga ggtcaagttc aactggtacg tggacggcgt ggaggtgcat      180

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgtaccgtgt ggtcagcgtc      240

ctcaccgtcc tgcaccagga ctggctgaat ggcaaggagt acaagtgcaa ggtctccaac      300

aaagccctcc cagcccccat cgagaaaacc atctccaaag ccaaagggca gccccgagaa      360

ccacaggtgt acaccctgcc cccatcccgg gatgagctga ccaagaacca ggtcagcctg      420

acctgcctgg tcaaaggctt ctatcccagc gacatcgccg tggagtggga gagcaatggg      480

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc      540

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacgt cttctcatgc      600

tccgtgatgc atgaggctct gcacaaccac tacacgcaga agagcctctc cctgtctccg      660

ggtaaa                                                                 666


<210>  11
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having SHH signal peptide

<400>  11

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            20                  25                  30          


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                85                  90                  95      


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        115                 120                 125             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Pro Gly Lys 
                245 


<210>  12
<211>  767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having SHH signal 
       peptide

<400>  12
aagcttgaat tcccaccatg ctgctgctgg cgagatgtct gctgctagtc ctcgtctcct       60

cgctgctggt atgctcggga ctggcgtgcc caccgtgccc agcacctgaa ctcctggggg      120

ggccctcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc tcccggaccc      180

ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc aagttcaact      240

ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag gagcagtaca      300

acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg ctgaatggca      360

aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag aaaaccatct      420

ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca tcccgggatg      480

agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat cccagcgaca      540

tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc acgcctcccg      600

tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac aagagcaggt      660

ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac aaccactaca      720

cgcagaagag cctctccctg tctccgggta aatgactcga gcggccg                    767


<210>  13
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having IFN signal peptide

<400>  13

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            20                  25                  30          


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                85                  90                  95      


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        115                 120                 125             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Pro Gly Lys 
                245 


<210>  14
<211>  767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having IFN signal 
       peptide

<400>  14
aagcttgaat tcccaccatg gccttgacct ttgctttact ggtggccctc ctggtgctca       60

gctgcaagtc aagctgctct gtgggctgcc caccgtgccc agcacctgaa ctcctggggg      120

ggccctcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc tcccggaccc      180

ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc aagttcaact      240

ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag gagcagtaca      300

acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg ctgaatggca      360

aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag aaaaccatct      420

ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca tcccgggatg      480

agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat cccagcgaca      540

tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc acgcctcccg      600

tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac aagagcaggt      660

ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac aaccactaca      720

cgcagaagag cctctccctg tctccgggta aatgactcga gcggccg                    767


<210>  15
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having CETP signal peptide

<400>  15

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            20                  25                  30          


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        35                  40                  45              


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    50                  55                  60                  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
65                  70                  75                  80  


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                85                  90                  95      


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            100                 105                 110         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        115                 120                 125             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    130                 135                 140                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
145                 150                 155                 160 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                165                 170                 175     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            180                 185                 190         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        195                 200                 205             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    210                 215                 220                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235                 


<210>  16
<211>  749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having CETP signal 
       peptide

<400>  16
aagcttgaat tcccaccatg ctggctgcca cagtcctgac cctggccctg ctgggcaatg       60

cccatgcctg cccaccgtgc ccagcacctg aactcctggg ggggccctca gtcttcctct      120

tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc acatgcgtgg      180

tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg gacggcgtgg      240

aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg taccgtgtgg      300

tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac aagtgcaagg      360

tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc aaagggcagc      420

cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc aagaaccagg      480

tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg gagtgggaga      540

gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct      600

ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacgtct      660

tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag agcctctccc      720

tgtctccggg taaatgactc gagcggccg                                        749


<210>  17
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc domain having the N-terminal sequence CPAPE

<400>  17

Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
1               5                   10                  15      


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            20                  25                  30          


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        35                  40                  45              


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    50                  55                  60                  


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
65                  70                  75                  80  


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                85                  90                  95      


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        115                 120                 125             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    130                 135                 140                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
145                 150                 155                 160 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                165                 170                 175     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            180                 185                 190         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        195                 200                 205             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 


<210>  18
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human IgG1 Fc domain having the N-terminal sequence 
       CPAPE

<400>  18
tgcccagcac ctgaactcct gggggggccc tcagtcttcc tcttcccccc aaaacccaag       60

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      120

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag      180

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc      240

ctgcaccagg actggctgaa tggcaaggag tacaagtgca aggtctccaa caaagccctc      300

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg      360

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg      420

gtcaaaggct tctatcccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag      480

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc      540

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg      600

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtaaa         657


<210>  19
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having SHH signal peptide

<400>  19

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    50                  55                  60                  


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
65                  70                  75                  80  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            100                 105                 110         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        115                 120                 125             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    130                 135                 140                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
145                 150                 155                 160 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                165                 170                 175     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            180                 185                 190         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        195                 200                 205             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    210                 215                 220                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
225                 230                 235                 240 


Gly Lys 
        


<210>  20
<211>  758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having SHH signal 
       peptide

<400>  20
aagcttgaat tcccaccatg ctgctgctgg cgagatgtct gctgctagtc ctcgtctcct       60

cgctgctggt atgctcggga ctggcgtgcc cagcacctga actcctgggg gggccctcag      120

tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc cctgaggtca      180

catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac tggtacgtgg      240

acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac aacagcacgt      300

accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc aaggagtaca      360

agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc tccaaagcca      420

aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat gagctgacca      480

agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac atcgccgtgg      540

agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc gtgctggact      600

ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg tggcagcagg      660

ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac acgcagaaga      720

gcctctccct gtctccgggt aaatgactcg agcggccg                              758


<210>  21
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having IFN signal peptide

<400>  21

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    50                  55                  60                  


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
65                  70                  75                  80  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            100                 105                 110         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        115                 120                 125             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    130                 135                 140                 


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
145                 150                 155                 160 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                165                 170                 175     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            180                 185                 190         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        195                 200                 205             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    210                 215                 220                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
225                 230                 235                 240 


Gly Lys 
        


<210>  22
<211>  758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having IFN signal 
       peptide

<400>  22
aagcttgaat tcccaccatg gccttgacct ttgctttact ggtggccctc ctggtgctca       60

gctgcaagtc aagctgctct gtgggctgcc cagcacctga actcctgggg gggccctcag      120

tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc cctgaggtca      180

catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac tggtacgtgg      240

acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac aacagcacgt      300

accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc aaggagtaca      360

agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc tccaaagcca      420

aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat gagctgacca      480

agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac atcgccgtgg      540

agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc gtgctggact      600

ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg tggcagcagg      660

ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac acgcagaaga      720

gcctctccct gtctccgggt aaatgactcg agcggccg                              758


<210>  23
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having CETP signal peptide

<400>  23

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            20                  25                  30          


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        35                  40                  45              


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    50                  55                  60                  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
65                  70                  75                  80  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                85                  90                  95      


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            100                 105                 110         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        115                 120                 125             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    130                 135                 140                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
145                 150                 155                 160 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                165                 170                 175     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            180                 185                 190         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        195                 200                 205             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    210                 215                 220                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235     


<210>  24
<211>  740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having CETP signal 
       peptide

<400>  24
aagcttgaat tcccaccatg ctggctgcca cagtcctgac cctggccctg ctgggcaatg       60

cccatgcctg cccagcacct gaactcctgg gggggccctc agtcttcctc ttccccccaa      120

aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg gtggtggacg      180

tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg gaggtgcata      240

atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc      300

tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag gtctccaaca      360

aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag ccccgagaac      420

cacaggtgta caccctgccc ccatcccggg atgagctgac caagaaccag gtcagcctga      480

cctgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag agcaatgggc      540

agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc tccttcttcc      600

tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc ttctcatgct      660

ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc ctgtctccgg      720

gtaaatgact cgagcggccg                                                  740


<210>  25
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc domain having the N-terminal sequence CCVECPPCPAPE

<400>  25

Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
1               5                   10                  15      


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            20                  25                  30          


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        35                  40                  45              


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    50                  55                  60                  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val 
65                  70                  75                  80  


Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu 
                85                  90                  95      


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys 
            100                 105                 110         


Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        115                 120                 125             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
    130                 135                 140                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
145                 150                 155                 160 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu 
                165                 170                 175     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            180                 185                 190         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        195                 200                 205             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220                 


Lys 
225 


<210>  26
<211>  675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human IgG2 Fc domain having the N-terminal sequence 
       CCVECPPCPAPE

<400>  26
tgttgtgtcg agtgcccacc gtgcccagca ccacctgtgg caggaccgtc agtcttcctc       60

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacgtgcgtg      120

gtggtggacg tgagccacga agaccccgag gtccagttca actggtacgt ggacggcgtg      180

gaggtgcata atgccaagac aaagccacgg gaggagcagt tcaacagcac gttccgtgtg      240

gtcagcgtcc tcaccgttgt gcaccaggac tggctgaacg gcaaggagta caagtgcaag      300

gtctccaaca aaggcctccc agcccccatc gagaaaacca tctccaaaac caaagggcag      360

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag      420

gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag      480

agcaatgggc agccggagaa caactacaag accacacctc ccatgctgga ctccgacggc      540

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc      600

ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc      660

ctgtctccgg gtaaa                                                       675


<210>  27
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having SHH signal peptide

<400>  27

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Cys Val Glu Cys Pro Pro Cys Pro 
            20                  25                  30          


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        35                  40                  45              


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    50                  55                  60                  


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
65                  70                  75                  80  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                85                  90                  95      


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
            100                 105                 110         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
        115                 120                 125             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
    130                 135                 140                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
145                 150                 155                 160 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                165                 170                 175     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            180                 185                 190         


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        195                 200                 205             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    210                 215                 220                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
225                 230                 235                 240 


Ser Leu Ser Leu Ser Pro Gly Lys 
                245             


<210>  28
<211>  776
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having SHH signal 
       peptide

<400>  28
aagcttgaat tcccaccatg ctgctgctgg cgagatgtct gctgctagtc ctcgtctcct       60

cgctgctggt atgctcggga ctggcgtgtt gtgtcgagtg cccaccgtgc ccagcaccac      120

ctgtggcagg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc ctcatgatct      180

cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccacgaagac cccgaggtcc      240

agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag ccacgggagg      300

agcagttcaa cagcacgttc cgtgtggtca gcgtcctcac cgttgtgcac caggactggc      360

tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccagcc cccatcgaga      420

aaaccatctc caaaaccaaa gggcagcccc gagaaccaca ggtgtacacc ctgcccccat      480

cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa ggcttctacc      540

ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac tacaagacca      600

cacctcccat gctggactcc gacggctcct tcttcctcta cagcaagctc accgtggaca      660

agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag gctctgcaca      720

accactacac gcagaagagc ctctccctgt ctccgggtaa atgactcgag cggccg          776


<210>  29
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having IFN signal peptide

<400>  29

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Cys Val Glu Cys Pro Pro Cys Pro 
            20                  25                  30          


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        35                  40                  45              


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    50                  55                  60                  


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
65                  70                  75                  80  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                85                  90                  95      


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
            100                 105                 110         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
        115                 120                 125             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
    130                 135                 140                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
145                 150                 155                 160 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                165                 170                 175     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            180                 185                 190         


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        195                 200                 205             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    210                 215                 220                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
225                 230                 235                 240 


Ser Leu Ser Leu Ser Pro Gly Lys 
                245             


<210>  30
<211>  776
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having IFN signal 
       peptide

<400>  30
aagcttgaat tcccaccatg gccttgacct ttgctttact ggtggccctc ctggtgctca       60

gctgcaagtc aagctgctct gtgggctgtt gtgtcgagtg cccaccgtgc ccagcaccac      120

ctgtggcagg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc ctcatgatct      180

cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccacgaagac cccgaggtcc      240

agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag ccacgggagg      300

agcagttcaa cagcacgttc cgtgtggtca gcgtcctcac cgttgtgcac caggactggc      360

tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccagcc cccatcgaga      420

aaaccatctc caaaaccaaa gggcagcccc gagaaccaca ggtgtacacc ctgcccccat      480

cccgggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa ggcttctacc      540

ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac tacaagacca      600

cacctcccat gctggactcc gacggctcct tcttcctcta cagcaagctc accgtggaca      660

agagcaggtg gcagcagggg aacgtcttct catgctccgt gatgcatgag gctctgcaca      720

accactacac gcagaagagc ctctccctgt ctccgggtaa atgactcgag cggccg          776


<210>  31
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having CETP signal peptide

<400>  31

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
            20                  25                  30          


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    50                  55                  60                  


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
65                  70                  75                  80  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
                85                  90                  95      


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
            100                 105                 110         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
        115                 120                 125             


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    130                 135                 140                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
145                 150                 155                 160 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                165                 170                 175     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
            180                 185                 190         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        195                 200                 205             


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    210                 215                 220                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
225                 230                 235                 240 


Gly Lys 
        


<210>  32
<211>  758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having CETP signal 
       peptide

<400>  32
aagcttgaat tcccaccatg ctggctgcca cagtcctgac cctggccctg ctgggcaatg       60

cccatgcctg ttgtgtcgag tgcccaccgt gcccagcacc acctgtggca ggaccgtcag      120

tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc cctgaggtca      180

cgtgcgtggt ggtggacgtg agccacgaag accccgaggt ccagttcaac tggtacgtgg      240

acggcgtgga ggtgcataat gccaagacaa agccacggga ggagcagttc aacagcacgt      300

tccgtgtggt cagcgtcctc accgttgtgc accaggactg gctgaacggc aaggagtaca      360

agtgcaaggt ctccaacaaa ggcctcccag cccccatcga gaaaaccatc tccaaaacca      420

aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag gagatgacca      480

agaaccaggt cagcctgacc tgcctggtca aaggcttcta ccccagcgac atcgccgtgg      540

agtgggagag caatgggcag ccggagaaca actacaagac cacacctccc atgctggact      600

ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg tggcagcagg      660

ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac acgcagaaga      720

gcctctccct gtctccgggt aaatgactcg agcggccg                              758


<210>  33
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc domain having the N-terminal sequence CVECPPCPAPE

<400>  33

Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        35                  40                  45              


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220                 


<210>  34
<211>  672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human IgG2 Fc domain having the N-terminal sequence 
       CVECPPCPAPE

<400>  34
tgtgtcgagt gcccaccgtg cccagcacca cctgtggcag gaccgtcagt cttcctcttc       60

cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg      120

gtggacgtga gccacgaaga ccccgaggtc cagttcaact ggtacgtgga cggcgtggag      180

gtgcataatg ccaagacaaa gccacgggag gagcagttca acagcacgtt ccgtgtggtc      240

agcgtcctca ccgttgtgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc      300

tccaacaaag gcctcccagc ccccatcgag aaaaccatct ccaaaaccaa agggcagccc      360

cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc      420

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc      480

aatgggcagc cggagaacaa ctacaagacc acacctccca tgctggactc cgacggctcc      540

ttcttcctct acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc      600

tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg      660

tctccgggta aa                                                          672


<210>  35
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having SHH signal peptide

<400>  35

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Val Glu Cys Pro Pro Cys Pro Ala 
            20                  25                  30          


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                85                  90                  95      


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Lys 
                245         


<210>  36
<211>  773
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having SHH signal 
       peptide

<400>  36
aagcttgaat tcccaccatg ctgctgctgg cgagatgtct gctgctagtc ctcgtctcct       60

cgctgctggt atgctcggga ctggcgtgtg tcgagtgccc accgtgccca gcaccacctg      120

tggcaggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc atgatctccc      180

ggacccctga ggtcacgtgc gtggtggtgg acgtgagcca cgaagacccc gaggtccagt      240

tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagcca cgggaggagc      300

agttcaacag cacgttccgt gtggtcagcg tcctcaccgt tgtgcaccag gactggctga      360

acggcaagga gtacaagtgc aaggtctcca acaaaggcct cccagccccc atcgagaaaa      420

ccatctccaa aaccaaaggg cagccccgag aaccacaggt gtacaccctg cccccatccc      480

gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc ttctacccca      540

gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacac      600

ctcccatgct ggactccgac ggctccttct tcctctacag caagctcacc gtggacaaga      660

gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct ctgcacaacc      720

actacacgca gaagagcctc tccctgtctc cgggtaaatg actcgagcgg ccg             773


<210>  37
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having IFN signal peptide

<400>  37

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Val Glu Cys Pro Pro Cys Pro Ala 
            20                  25                  30          


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                85                  90                  95      


Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        115                 120                 125             


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Lys 
                245         


<210>  38
<211>  773
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having IFN signal 
       peptide

<400>  38
aagcttgaat tcccaccatg gccttgacct ttgctttact ggtggccctc ctggtgctca       60

gctgcaagtc aagctgctct gtgggctgtg tcgagtgccc accgtgccca gcaccacctg      120

tggcaggacc gtcagtcttc ctcttccccc caaaacccaa ggacaccctc atgatctccc      180

ggacccctga ggtcacgtgc gtggtggtgg acgtgagcca cgaagacccc gaggtccagt      240

tcaactggta cgtggacggc gtggaggtgc ataatgccaa gacaaagcca cgggaggagc      300

agttcaacag cacgttccgt gtggtcagcg tcctcaccgt tgtgcaccag gactggctga      360

acggcaagga gtacaagtgc aaggtctcca acaaaggcct cccagccccc atcgagaaaa      420

ccatctccaa aaccaaaggg cagccccgag aaccacaggt gtacaccctg cccccatccc      480

gggaggagat gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc ttctacccca      540

gcgacatcgc cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacac      600

ctcccatgct ggactccgac ggctccttct tcctctacag caagctcacc gtggacaaga      660

gcaggtggca gcaggggaac gtcttctcat gctccgtgat gcatgaggct ctgcacaacc      720

actacacgca gaagagcctc tccctgtctc cgggtaaatg actcgagcgg ccg             773


<210>  39
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having CETP signal peptide

<400>  39

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys 
    


<210>  40
<211>  755
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having CETP signal 
       peptide

<400>  40
aagcttgaat tcccaccatg ctggctgcca cagtcctgac cctggccctg ctgggcaatg       60

cccatgcctg tgtcgagtgc ccaccgtgcc cagcaccacc tgtggcagga ccgtcagtct      120

tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacgt      180

gcgtggtggt ggacgtgagc cacgaagacc ccgaggtcca gttcaactgg tacgtggacg      240

gcgtggaggt gcataatgcc aagacaaagc cacgggagga gcagttcaac agcacgttcc      300

gtgtggtcag cgtcctcacc gttgtgcacc aggactggct gaacggcaag gagtacaagt      360

gcaaggtctc caacaaaggc ctcccagccc ccatcgagaa aaccatctcc aaaaccaaag      420

ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag atgaccaaga      480

accaggtcag cctgacctgc ctggtcaaag gcttctaccc cagcgacatc gccgtggagt      540

gggagagcaa tgggcagccg gagaacaact acaagaccac acctcccatg ctggactccg      600

acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga      660

acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc      720

tctccctgtc tccgggtaaa tgactcgagc ggccg                                 755


<210>  41
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc domain having the N-terminal sequence CPPCPAPE

<400>  41

Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
1               5                   10                  15      


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            20                  25                  30          


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
        35                  40                  45              


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    50                  55                  60                  


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
65                  70                  75                  80  


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                85                  90                  95      


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            100                 105                 110         


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        115                 120                 125             


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    130                 135                 140                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
145                 150                 155                 160 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
                165                 170                 175     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220     


<210>  42
<211>  663
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human IgG2 Fc domain having the N-terminal sequence 
       CPPCPAPE

<400>  42
tgcccaccgt gcccagcacc acctgtggca ggaccgtcag tcttcctctt ccccccaaaa       60

cccaaggaca ccctcatgat ctcccggacc cctgaggtca cgtgcgtggt ggtggacgtg      120

agccacgaag accccgaggt ccagttcaac tggtacgtgg acggcgtgga ggtgcataat      180

gccaagacaa agccacggga ggagcagttc aacagcacgt tccgtgtggt cagcgtcctc      240

accgttgtgc accaggactg gctgaacggc aaggagtaca agtgcaaggt ctccaacaaa      300

ggcctcccag cccccatcga gaaaaccatc tccaaaacca aagggcagcc ccgagaacca      360

caggtgtaca ccctgccccc atcccgggag gagatgacca agaaccaggt cagcctgacc      420

tgcctggtca aaggcttcta ccccagcgac atcgccgtgg agtgggagag caatgggcag      480

ccggagaaca actacaagac cacacctccc atgctggact ccgacggctc cttcttcctc      540

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc      600

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt      660

aaa                                                                    663


<210>  43
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having SHH signal peptide

<400>  43

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Pro Cys Pro Ala Pro Pro Val 
            20                  25                  30          


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        35                  40                  45              


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    50                  55                  60                  


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
65                  70                  75                  80  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                85                  90                  95      


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
            100                 105                 110         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
        115                 120                 125             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
    130                 135                 140                 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
145                 150                 155                 160 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                165                 170                 175     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            180                 185                 190         


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        195                 200                 205             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    210                 215                 220                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
225                 230                 235                 240 


Ser Pro Gly Lys 
                


<210>  44
<211>  764
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having SHH signal 
       peptide

<400>  44
aagcttgaat tcccaccatg ctgctgctgg cgagatgtct gctgctagtc ctcgtctcct       60

cgctgctggt atgctcggga ctggcgtgcc caccgtgccc agcaccacct gtggcaggac      120

cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc cggacccctg      180

aggtcacgtg cgtggtggtg gacgtgagcc acgaagaccc cgaggtccag ttcaactggt      240

acgtggacgg cgtggaggtg cataatgcca agacaaagcc acgggaggag cagttcaaca      300

gcacgttccg tgtggtcagc gtcctcaccg ttgtgcacca ggactggctg aacggcaagg      360

agtacaagtg caaggtctcc aacaaaggcc tcccagcccc catcgagaaa accatctcca      420

aaaccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc cgggaggaga      480

tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctacccc agcgacatcg      540

ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccaca cctcccatgc      600

tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag agcaggtggc      660

agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac cactacacgc      720

agaagagcct ctccctgtct ccgggtaaat gactcgagcg gccg                       764


<210>  45
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having IFN signal peptide

<400>  45

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Pro Cys Pro Ala Pro Pro Val 
            20                  25                  30          


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        35                  40                  45              


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    50                  55                  60                  


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
65                  70                  75                  80  


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
                85                  90                  95      


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
            100                 105                 110         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
        115                 120                 125             


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
    130                 135                 140                 


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
145                 150                 155                 160 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                165                 170                 175     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            180                 185                 190         


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        195                 200                 205             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    210                 215                 220                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
225                 230                 235                 240 


Ser Pro Gly Lys 
                


<210>  46
<211>  764
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having IFN signal 
       peptide

<400>  46
aagcttgaat tcccaccatg gccttgacct ttgctttact ggtggccctc ctggtgctca       60

gctgcaagtc aagctgctct gtgggctgcc caccgtgccc agcaccacct gtggcaggac      120

cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc cggacccctg      180

aggtcacgtg cgtggtggtg gacgtgagcc acgaagaccc cgaggtccag ttcaactggt      240

acgtggacgg cgtggaggtg cataatgcca agacaaagcc acgggaggag cagttcaaca      300

gcacgttccg tgtggtcagc gtcctcaccg ttgtgcacca ggactggctg aacggcaagg      360

agtacaagtg caaggtctcc aacaaaggcc tcccagcccc catcgagaaa accatctcca      420

aaaccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc cgggaggaga      480

tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctacccc agcgacatcg      540

ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccaca cctcccatgc      600

tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag agcaggtggc      660

agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac cactacacgc      720

agaagagcct ctccctgtct ccgggtaaat gactcgagcg gccg                       764


<210>  47
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having CETP signal peptide

<400>  47

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
            20                  25                  30          


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        35                  40                  45              


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    50                  55                  60                  


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
65                  70                  75                  80  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
                85                  90                  95      


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            100                 105                 110         


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        115                 120                 125             


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
    130                 135                 140                 


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
145                 150                 155                 160 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                165                 170                 175     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
            180                 185                 190         


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        195                 200                 205             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    210                 215                 220                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235             


<210>  48
<211>  746
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having CETP signal 
       peptide

<400>  48
aagcttgaat tcccaccatg ctggctgcca cagtcctgac cctggccctg ctgggcaatg       60

cccatgcctg cccaccgtgc ccagcaccac ctgtggcagg accgtcagtc ttcctcttcc      120

ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg      180

tggacgtgag ccacgaagac cccgaggtcc agttcaactg gtacgtggac ggcgtggagg      240

tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc cgtgtggtca      300

gcgtcctcac cgttgtgcac caggactggc tgaacggcaa ggagtacaag tgcaaggtct      360

ccaacaaagg cctcccagcc cccatcgaga aaaccatctc caaaaccaaa gggcagcccc      420

gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag aaccaggtca      480

gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag tgggagagca      540

atgggcagcc ggagaacaac tacaagacca cacctcccat gctggactcc gacggctcct      600

tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg aacgtcttct      660

catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc ctctccctgt      720

ctccgggtaa atgactcgag cggccg                                           746


<210>  49
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 Fc domain having the N-terminal sequence CPAPE

<400>  49

Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
1               5                   10                  15      


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
            20                  25                  30          


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp 
        35                  40                  45              


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
    50                  55                  60                  


Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val 
65                  70                  75                  80  


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
                85                  90                  95      


Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly 
            100                 105                 110         


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
        115                 120                 125             


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
    130                 135                 140                 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
145                 150                 155                 160 


Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe 
                165                 170                 175     


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
            180                 185                 190         


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        195                 200                 205             


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215             


<210>  50
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human IgG2 Fc domain having the N-terminal sequence 
       CPAPE

<400>  50
tgcccagcac cacctgtggc aggaccgtca gtcttcctct tccccccaaa acccaaggac       60

accctcatga tctcccggac ccctgaggtc acgtgcgtgg tggtggacgt gagccacgaa      120

gaccccgagg tccagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca      180

aagccacggg aggagcagtt caacagcacg ttccgtgtgg tcagcgtcct caccgttgtg      240

caccaggact ggctgaacgg caaggagtac aagtgcaagg tctccaacaa aggcctccca      300

gcccccatcg agaaaaccat ctccaaaacc aaagggcagc cccgagaacc acaggtgtac      360

accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc      420

aaaggcttct accccagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac      480

aactacaaga ccacacctcc catgctggac tccgacggct ccttcttcct ctacagcaag      540

ctcaccgtgg acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat      600

gaggctctgc acaaccacta cacgcagaag agcctctccc tgtctccggg taaa            654


<210>  51
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having SHH signal peptide

<400>  51

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys 
    


<210>  52
<211>  755
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having SHH signal 
       peptide

<400>  52
aagcttgaat tcccaccatg ctgctgctgg cgagatgtct gctgctagtc ctcgtctcct       60

cgctgctggt atgctcggga ctggcgtgcc cagcaccacc tgtggcagga ccgtcagtct      120

tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacgt      180

gcgtggtggt ggacgtgagc cacgaagacc ccgaggtcca gttcaactgg tacgtggacg      240

gcgtggaggt gcataatgcc aagacaaagc cacgggagga gcagttcaac agcacgttcc      300

gtgtggtcag cgtcctcacc gttgtgcacc aggactggct gaacggcaag gagtacaagt      360

gcaaggtctc caacaaaggc ctcccagccc ccatcgagaa aaccatctcc aaaaccaaag      420

ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag atgaccaaga      480

accaggtcag cctgacctgc ctggtcaaag gcttctaccc cagcgacatc gccgtggagt      540

gggagagcaa tgggcagccg gagaacaact acaagaccac acctcccatg ctggactccg      600

acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga      660

acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc      720

tctccctgtc tccgggtaaa tgactcgagc ggccg                                 755


<210>  53
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having IFN signal peptide

<400>  53

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Ala Pro Pro Val Ala Gly Pro 
            20                  25                  30          


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        35                  40                  45              


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    50                  55                  60                  


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
65                  70                  75                  80  


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val 
                85                  90                  95      


Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu 
            100                 105                 110         


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys 
        115                 120                 125             


Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    130                 135                 140                 


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
145                 150                 155                 160 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                165                 170                 175     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu 
            180                 185                 190         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        195                 200                 205             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    210                 215                 220                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235                 240 


Lys 
    


<210>  54
<211>  755
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having IFN signal 
       peptide

<400>  54
aagcttgaat tcccaccatg gccttgacct ttgctttact ggtggccctc ctggtgctca       60

gctgcaagtc aagctgctct gtgggctgcc cagcaccacc tgtggcagga ccgtcagtct      120

tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct gaggtcacgt      180

gcgtggtggt ggacgtgagc cacgaagacc ccgaggtcca gttcaactgg tacgtggacg      240

gcgtggaggt gcataatgcc aagacaaagc cacgggagga gcagttcaac agcacgttcc      300

gtgtggtcag cgtcctcacc gttgtgcacc aggactggct gaacggcaag gagtacaagt      360

gcaaggtctc caacaaaggc ctcccagccc ccatcgagaa aaccatctcc aaaaccaaag      420

ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag atgaccaaga      480

accaggtcag cctgacctgc ctggtcaaag gcttctaccc cagcgacatc gccgtggagt      540

gggagagcaa tgggcagccg gagaacaact acaagaccac acctcccatg ctggactccg      600

acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg cagcagggga      660

acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg cagaagagcc      720

tctccctgtc tccgggtaaa tgactcgagc ggccg                                 755


<210>  55
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having CETP signal peptide

<400>  55

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235 


<210>  56
<211>  737
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having CETP signal 
       peptide

<400>  56
aagcttgaat tcccaccatg ctggctgcca cagtcctgac cctggccctg ctgggcaatg       60

cccatgcctg cccagcacca cctgtggcag gaccgtcagt cttcctcttc cccccaaaac      120

ccaaggacac cctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg gtggacgtga      180

gccacgaaga ccccgaggtc cagttcaact ggtacgtgga cggcgtggag gtgcataatg      240

ccaagacaaa gccacgggag gagcagttca acagcacgtt ccgtgtggtc agcgtcctca      300

ccgttgtgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc tccaacaaag      360

gcctcccagc ccccatcgag aaaaccatct ccaaaaccaa agggcagccc cgagaaccac      420

aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc agcctgacct      480

gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc aatgggcagc      540

cggagaacaa ctacaagacc acacctccca tgctggactc cgacggctcc ttcttcctct      600

acagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg      660

tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg tctccgggta      720

aatgactcga gcggccg                                                     737


<210>  57
<211>  267
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG3 Fc domain having the N-terminal sequence 
       (CPRCPEPKSDTPPP)3-CPRCPAPE

<400>  57

Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
1               5                   10                  15      


Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
            20                  25                  30          


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        35                  40                  45              


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
    50                  55                  60                  


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
65                  70                  75                  80  


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys 
                85                  90                  95      


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
            100                 105                 110         


Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
        115                 120                 125             


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
    130                 135                 140                 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
145                 150                 155                 160 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
                165                 170                 175     


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            180                 185                 190         


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu 
        195                 200                 205             


Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    210                 215                 220                 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
225                 230                 235                 240 


Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
                245                 250                 255     


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 265         


<210>  58
<211>  801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human IgG3 Fc domain having the N-terminal sequence 
       (CPRCPEPKSDTPPP)3-CPRCPAPE

<400>  58
tgcccacggt gcccagagcc caaatcttgt gacacacctc ccccgtgccc acggtgccca       60

gagcccaaat cttgtgacac acctccccca tgcccacggt gcccagagcc caaatcttgt      120

gacacacctc ccccgtgccc aaggtgccca gcacctgaac tcctgggagg accgtcagtc      180

ttcctcttcc ccccaaaacc caaggatacc cttatgattt cccggacccc tgaggtcacg      240

tgcgtggtgg tggacgtgag ccacgaagac cccgaggtcc agttcaagtg gtacgtggac      300

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgttc      360

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      420

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaaaccaaa      480

ggacagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag      540

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      600

tgggagagca gcgggcagcc ggagaacaac tacaacacca cgcctcccat gctggactcc      660

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      720

aacatcttct catgctccgt gatgcatgag gctctgcaca accgcttcac gcagaagagc      780

ctctccctgt ctccgggtaa a                                                801


<210>  59
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide  having SHH signal peptide

<400>  59

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Arg Cys Pro Glu Pro Lys Ser 
            20                  25                  30          


Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys 
        35                  40                  45              


Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    50                  55                  60                  


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg 
    130                 135                 140                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  60
<211>  902
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide  having SHH signal 
       peptide

<400>  60
aagcttgaat tcccaccatg ctgctgctgg cgagatgtct gctgctagtc ctcgtctcct       60

cgctgctggt atgctcggga ctggcgtgcc cacggtgccc agagcccaaa tcttgtgaca      120

cacctccccc gtgcccacgg tgcccagagc ccaaatcttg tgacacacct cccccatgcc      180

cacggtgccc agagcccaaa tcttgtgaca cacctccccc gtgcccaagg tgcccagcac      240

ctgaactcct gggaggaccg tcagtcttcc tcttcccccc aaaacccaag gataccctta      300

tgatttcccg gacccctgag gtcacgtgcg tggtggtgga cgtgagccac gaagaccccg      360

aggtccagtt caagtggtac gtggacggcg tggaggtgca taatgccaag acaaagccgc      420

gggaggagca gtacaacagc acgttccgtg tggtcagcgt cctcaccgtc ctgcaccagg      480

actggctgaa cggcaaggag tacaagtgca aggtctccaa caaagccctc ccagccccca      540

tcgagaaaac catctccaaa accaaaggac agccccgaga accacaggtg tacaccctgc      600

ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg gtcaaaggct      660

tctaccccag cgacatcgcc gtggagtggg agagcagcgg gcagccggag aacaactaca      720

acaccacgcc tcccatgctg gactccgacg gctccttctt cctctacagc aagctcaccg      780

tggacaagag caggtggcag caggggaaca tcttctcatg ctccgtgatg catgaggctc      840

tgcacaaccg cttcacgcag aagagcctct ccctgtctcc gggtaaatga ctcgagcggc      900

cg                                                                     902


<210>  61
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide  having IFN signal peptide

<400>  61

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Arg Cys Pro Glu Pro Lys Ser 
            20                  25                  30          


Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys 
        35                  40                  45              


Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp 
    50                  55                  60                  


Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly 
65                  70                  75                  80  


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                85                  90                  95      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            100                 105                 110         


Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His 
        115                 120                 125             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg 
    130                 135                 140                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
145                 150                 155                 160 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                165                 170                 175     


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            180                 185                 190         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        195                 200                 205             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    210                 215                 220                 


Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met 
225                 230                 235                 240 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                245                 250                 255     


Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His 
            260                 265                 270         


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        275                 280                 285             


Gly Lys 
    290 


<210>  62
<211>  902
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having IFN signal 
       peptide

<400>  62
aagcttgaat tcccaccatg gccttgacct ttgctttact ggtggccctc ctggtgctca       60

gctgcaagtc aagctgctct gtgggctgcc cacggtgccc agagcccaaa tcttgtgaca      120

cacctccccc gtgcccacgg tgcccagagc ccaaatcttg tgacacacct cccccatgcc      180

cacggtgccc agagcccaaa tcttgtgaca cacctccccc gtgcccaagg tgcccagcac      240

ctgaactcct gggaggaccg tcagtcttcc tcttcccccc aaaacccaag gataccctta      300

tgatttcccg gacccctgag gtcacgtgcg tggtggtgga cgtgagccac gaagaccccg      360

aggtccagtt caagtggtac gtggacggcg tggaggtgca taatgccaag acaaagccgc      420

gggaggagca gtacaacagc acgttccgtg tggtcagcgt cctcaccgtc ctgcaccagg      480

actggctgaa cggcaaggag tacaagtgca aggtctccaa caaagccctc ccagccccca      540

tcgagaaaac catctccaaa accaaaggac agccccgaga accacaggtg tacaccctgc      600

ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg gtcaaaggct      660

tctaccccag cgacatcgcc gtggagtggg agagcagcgg gcagccggag aacaactaca      720

acaccacgcc tcccatgctg gactccgacg gctccttctt cctctacagc aagctcaccg      780

tggacaagag caggtggcag caggggaaca tcttctcatg ctccgtgatg catgaggctc      840

tgcacaaccg cttcacgcag aagagcctct ccctgtctcc gggtaaatga ctcgagcggc      900

cg                                                                     902


<210>  63
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having CETP signal peptide

<400>  63

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
            20                  25                  30          


Cys Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys 
        35                  40                  45              


Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 
    50                  55                  60                  


Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
65                  70                  75                  80  


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                85                  90                  95      


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            100                 105                 110         


Lys Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        115                 120                 125             


Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    130                 135                 140                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
145                 150                 155                 160 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                165                 170                 175     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            180                 185                 190         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        195                 200                 205             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro 
    210                 215                 220                 


Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
225                 230                 235                 240 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                245                 250                 255     


Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg 
            260                 265                 270         


Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        275                 280                 


<210>  64
<211>  884
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having CETP signal 
       peptide

<400>  64
aagcttgaat tcccaccatg ctggctgcca cagtcctgac cctggccctg ctgggcaatg       60

cccatgcctg cccacggtgc ccagagccca aatcttgtga cacacctccc ccgtgcccac      120

ggtgcccaga gcccaaatct tgtgacacac ctcccccatg cccacggtgc ccagagccca      180

aatcttgtga cacacctccc ccgtgcccaa ggtgcccagc acctgaactc ctgggaggac      240

cgtcagtctt cctcttcccc ccaaaaccca aggataccct tatgatttcc cggacccctg      300

aggtcacgtg cgtggtggtg gacgtgagcc acgaagaccc cgaggtccag ttcaagtggt      360

acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag cagtacaaca      420

gcacgttccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg aacggcaagg      480

agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa accatctcca      540

aaaccaaagg acagccccga gaaccacagg tgtacaccct gcccccatcc cgggaggaga      600

tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctacccc agcgacatcg      660

ccgtggagtg ggagagcagc gggcagccgg agaacaacta caacaccacg cctcccatgc      720

tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag agcaggtggc      780

agcaggggaa catcttctca tgctccgtga tgcatgaggc tctgcacaac cgcttcacgc      840

agaagagcct ctccctgtct ccgggtaaat gactcgagcg gccg                       884


<210>  65
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG3 Fc domain having the N-terminal sequence CPRCPAPE

<400>  65

Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220         


<210>  66
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA  encoding human IgG3 Fc domain having the N-terminal sequence
       CPRCPAPE

<400>  66
tgcccaaggt gcccagcacc tgaactcctg ggaggaccgt cagtcttcct cttcccccca       60

aaacccaagg atacccttat gatttcccgg acccctgagg tcacgtgcgt ggtggtggac      120

gtgagccacg aagaccccga ggtccagttc aagtggtacg tggacggcgt ggaggtgcat      180

aatgccaaga caaagccgcg ggaggagcag tacaacagca cgttccgtgt ggtcagcgtc      240

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac      300

aaagccctcc cagcccccat cgagaaaacc atctccaaaa ccaaaggaca gccccgagaa      360

ccacaggtgt acaccctgcc cccatcccgg gaggagatga ccaagaacca ggtcagcctg      420

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcagcggg      480

cagccggaga acaactacaa caccacgcct cccatgctgg actccgacgg ctccttcttc      540

ctctacagca agctcaccgt ggacaagagc aggtggcagc aggggaacat cttctcatgc      600

tccgtgatgc atgaggctct gcacaaccgc ttcacgcaga agagcctctc cctgtctccg      660

ggtaaatgac tcgagcggcc g                                                681


<210>  67
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having SHH signal peptide

<400>  67

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Arg Cys Pro Ala Pro Glu Leu 
            20                  25                  30          


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                85                  90                  95      


Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        115                 120                 125             


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr 
            180                 185                 190         


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Pro Gly Lys 
                245 


<210>  68
<211>  767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having SHH signal 
       peptide

<400>  68
aagcttgaat tcccaccatg ctgctgctgg cgagatgtct gctgctagtc ctcgtctcct       60

cgctgctggt atgctcggga ctggcgtgcc caaggtgccc agcacctgaa ctcctgggag      120

gaccgtcagt cttcctcttc cccccaaaac ccaaggatac ccttatgatt tcccggaccc      180

ctgaggtcac gtgcgtggtg gtggacgtga gccacgaaga ccccgaggtc cagttcaagt      240

ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag gagcagtaca      300

acagcacgtt ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg ctgaacggca      360

aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag aaaaccatct      420

ccaaaaccaa aggacagccc cgagaaccac aggtgtacac cctgccccca tcccgggagg      480

agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctac cccagcgaca      540

tcgccgtgga gtgggagagc agcgggcagc cggagaacaa ctacaacacc acgcctccca      600

tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac aagagcaggt      660

ggcagcaggg gaacatcttc tcatgctccg tgatgcatga ggctctgcac aaccgcttca      720

cgcagaagag cctctccctg tctccgggta aatgactcga gcggccg                    767


<210>  69
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having IFN signal peptide

<400>  69

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Arg Cys Pro Ala Pro Glu Leu 
            20                  25                  30          


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                85                  90                  95      


Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        115                 120                 125             


Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr 
            180                 185                 190         


Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Pro Gly Lys 
                245 


<210>  70
<211>  767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having IFN signal 
       peptide

<400>  70
aagcttgaat tcccaccatg gccttgacct ttgctttact ggtggccctc ctggtgctca       60

gctgcaagtc aagctgctct gtgggctgcc caaggtgccc agcacctgaa ctcctgggag      120

gaccgtcagt cttcctcttc cccccaaaac ccaaggatac ccttatgatt tcccggaccc      180

ctgaggtcac gtgcgtggtg gtggacgtga gccacgaaga ccccgaggtc cagttcaagt      240

ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag gagcagtaca      300

acagcacgtt ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg ctgaacggca      360

aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag aaaaccatct      420

ccaaaaccaa aggacagccc cgagaaccac aggtgtacac cctgccccca tcccgggagg      480

agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctac cccagcgaca      540

tcgccgtgga gtgggagagc agcgggcagc cggagaacaa ctacaacacc acgcctccca      600

tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac aagagcaggt      660

ggcagcaggg gaacatcttc tcatgctccg tgatgcatga ggctctgcac aaccgcttca      720

cgcagaagag cctctccctg tctccgggta aatgactcga gcggccg                    767


<210>  71
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having CETP signal peptide

<400>  71

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            20                  25                  30          


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        35                  40                  45              


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    50                  55                  60                  


Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
65                  70                  75                  80  


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser 
                85                  90                  95      


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            100                 105                 110         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        115                 120                 125             


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    130                 135                 140                 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
145                 150                 155                 160 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser 
                165                 170                 175     


Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser 
            180                 185                 190         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        195                 200                 205             


Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu 
    210                 215                 220                 


His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235                 


<210>  72
<211>  749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having CETP signal 
       peptide

<400>  72
aagcttgaat tcccaccatg ctggctgcca cagtcctgac cctggccctg ctgggcaatg       60

cccatgcctg cccaaggtgc ccagcacctg aactcctggg aggaccgtca gtcttcctct      120

tccccccaaa acccaaggat acccttatga tttcccggac ccctgaggtc acgtgcgtgg      180

tggtggacgt gagccacgaa gaccccgagg tccagttcaa gtggtacgtg gacggcgtgg      240

aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg ttccgtgtgg      300

tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac aagtgcaagg      360

tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaaacc aaaggacagc      420

cccgagaacc acaggtgtac accctgcccc catcccggga ggagatgacc aagaaccagg      480

tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg gagtgggaga      540

gcagcgggca gccggagaac aactacaaca ccacgcctcc catgctggac tccgacggct      600

ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag gggaacatct      660

tctcatgctc cgtgatgcat gaggctctgc acaaccgctt cacgcagaag agcctctccc      720

tgtctccggg taaatgactc gagcggccg                                        749


<210>  73
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG3 Fc domain having the N-terminal sequence CPAPE

<400>  73

Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
1               5                   10                  15      


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            20                  25                  30          


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys 
        35                  40                  45              


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    50                  55                  60                  


Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
65                  70                  75                  80  


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                85                  90                  95      


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            100                 105                 110         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
        115                 120                 125             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    130                 135                 140                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu 
145                 150                 155                 160 


Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
                165                 170                 175     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            180                 185                 190         


Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
        195                 200                 205             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 


<210>  74
<211>  672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human IgG3 Fc domain having the N-terminal sequence 
       CPAPE

<400>  74
tgcccagcac ctgaactcct gggaggaccg tcagtcttcc tcttcccccc aaaacccaag       60

gataccctta tgatttcccg gacccctgag gtcacgtgcg tggtggtgga cgtgagccac      120

gaagaccccg aggtccagtt caagtggtac gtggacggcg tggaggtgca taatgccaag      180

acaaagccgc gggaggagca gtacaacagc acgttccgtg tggtcagcgt cctcaccgtc      240

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtctccaa caaagccctc      300

ccagccccca tcgagaaaac catctccaaa accaaaggac agccccgaga accacaggtg      360

tacaccctgc ccccatcccg ggaggagatg accaagaacc aggtcagcct gacctgcctg      420

gtcaaaggct tctaccccag cgacatcgcc gtggagtggg agagcagcgg gcagccggag      480

aacaactaca acaccacgcc tcccatgctg gactccgacg gctccttctt cctctacagc      540

aagctcaccg tggacaagag caggtggcag caggggaaca tcttctcatg ctccgtgatg      600

catgaggctc tgcacaaccg cttcacgcag aagagcctct ccctgtctcc gggtaaatga      660

ctcgagcggc cg                                                          672


<210>  75
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having SHH signal peptide

<400>  75

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    50                  55                  60                  


Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His 
65                  70                  75                  80  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg 
                85                  90                  95      


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            100                 105                 110         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        115                 120                 125             


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    130                 135                 140                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
145                 150                 155                 160 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                165                 170                 175     


Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met 
            180                 185                 190         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        195                 200                 205             


Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His 
    210                 215                 220                 


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
225                 230                 235                 240 


Gly Lys 
        


<210>  76
<211>  758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having SHH signal 
       peptide

<400>  76
aagcttgaat tcccaccatg ctgctgctgg cgagatgtct gctgctagtc ctcgtctcct       60

cgctgctggt atgctcggga ctggcgtgcc cagcacctga actcctggga ggaccgtcag      120

tcttcctctt ccccccaaaa cccaaggata cccttatgat ttcccggacc cctgaggtca      180

cgtgcgtggt ggtggacgtg agccacgaag accccgaggt ccagttcaag tggtacgtgg      240

acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac aacagcacgt      300

tccgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc aaggagtaca      360

agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc tccaaaacca      420

aaggacagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag gagatgacca      480

agaaccaggt cagcctgacc tgcctggtca aaggcttcta ccccagcgac atcgccgtgg      540

agtgggagag cagcgggcag ccggagaaca actacaacac cacgcctccc atgctggact      600

ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg tggcagcagg      660

ggaacatctt ctcatgctcc gtgatgcatg aggctctgca caaccgcttc acgcagaaga      720

gcctctccct gtctccgggt aaatgactcg agcggccg                              758


<210>  77
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having IFN signal peptide

<400>  77

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    50                  55                  60                  


Asp Pro Glu Val Gln Phe Lys Trp Tyr Val Asp Gly Val Glu Val His 
65                  70                  75                  80  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg 
                85                  90                  95      


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            100                 105                 110         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        115                 120                 125             


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    130                 135                 140                 


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
145                 150                 155                 160 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                165                 170                 175     


Glu Ser Ser Gly Gln Pro Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met 
            180                 185                 190         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        195                 200                 205             


Lys Ser Arg Trp Gln Gln Gly Asn Ile Phe Ser Cys Ser Val Met His 
    210                 215                 220                 


Glu Ala Leu His Asn Arg Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro 
225                 230                 235                 240 


Gly Lys 
        


<210>  78
<211>  758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having IFN signal 
       peptide

<400>  78
aagcttgaat tcccaccatg gccttgacct ttgctttact ggtggccctc ctggtgctca       60

gctgcaagtc aagctgctct gtgggctgcc cagcacctga actcctggga ggaccgtcag      120

tcttcctctt ccccccaaaa cccaaggata cccttatgat ttcccggacc cctgaggtca      180

cgtgcgtggt ggtggacgtg agccacgaag accccgaggt ccagttcaag tggtacgtgg      240

acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac aacagcacgt      300

tccgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc aaggagtaca      360

agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc tccaaaacca      420

aaggacagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag gagatgacca      480

agaaccaggt cagcctgacc tgcctggtca aaggcttcta ccccagcgac atcgccgtgg      540

agtgggagag cagcgggcag ccggagaaca actacaacac cacgcctccc atgctggact      600

ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg tggcagcagg      660

ggaacatctt ctcatgctcc gtgatgcatg aggctctgca caaccgcttc acgcagaaga      720

gcctctccct gtctccgggt aaatgactcg agcggccg                              758


<210>  79
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having CETP signal peptide

<400>  79

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            20                  25                  30          


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        35                  40                  45              


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
    50                  55                  60                  


Lys Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
65                  70                  75                  80  


Arg Glu Glu Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
                85                  90                  95      


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            100                 105                 110         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
        115                 120                 125             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    130                 135                 140                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
145                 150                 155                 160 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro 
                165                 170                 175     


Glu Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
            180                 185                 190         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        195                 200                 205             


Gly Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg 
    210                 215                 220                 


Phe Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230                 235 


<210>  80
<211>  740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having CETP signal 
       peptide

<400>  80
aagcttgaat tcccaccatg ctggctgcca cagtcctgac cctggccctg ctgggcaatg       60

cccatgcctg cccagcacct gaactcctgg gaggaccgtc agtcttcctc ttccccccaa      120

aacccaagga tacccttatg atttcccgga cccctgaggt cacgtgcgtg gtggtggacg      180

tgagccacga agaccccgag gtccagttca agtggtacgt ggacggcgtg gaggtgcata      240

atgccaagac aaagccgcgg gaggagcagt acaacagcac gttccgtgtg gtcagcgtcc      300

tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag gtctccaaca      360

aagccctccc agcccccatc gagaaaacca tctccaaaac caaaggacag ccccgagaac      420

cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag gtcagcctga      480

cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag agcagcgggc      540

agccggagaa caactacaac accacgcctc ccatgctgga ctccgacggc tccttcttcc      600

tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacatc ttctcatgct      660

ccgtgatgca tgaggctctg cacaaccgct tcacgcagaa gagcctctcc ctgtctccgg      720

gtaaatgact cgagcggccg                                                  740


<210>  81
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 Fc domain having the N-terminal sequence CPSCPAPE

<400>  81

Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        35                  40                  45              


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215                 220         


<210>  82
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human IgG4 Fc domain having the N-terminal sequence 
       CPSCPAPE

<400>  82
tgcccatcat gcccagcacc tgagttcctg gggggaccat cagtcttcct gttcccccca       60

aaacccaagg acactctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      120

gtgagccagg aagaccccga ggtccagttc aactggtacg tggatggcgt ggaggtgcat      180

aatgccaaga caaagccgcg ggaggagcag ttcaacagca cgtaccgtgt ggtcagcgtc      240

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac      300

aaaggcctcc cgtcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagag      360

ccacaggtgt acaccctgcc cccatcccag gaggagatga ccaagaacca ggtcagcctg      420

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg      480

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc      540

ctctacagca ggctaaccgt ggacaagagc aggtggcagg aggggaatgt cttctcatgc      600

tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc cctgtctctg      660

ggtaaa                                                                 666


<210>  83
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having a SHH signal peptide

<400>  83

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Ser Cys Pro Ala Pro Glu Phe 
            20                  25                  30          


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                85                  90                  95      


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
        115                 120                 125             


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Leu Gly Lys 
                245 


<210>  84
<211>  767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having a SHH signal 
       peptide

<400>  84
aagcttgaat tcccaccatg ctgctgctgg cgagatgtct gctgctagtc ctcgtctcct       60

cgctgctggt atgctcggga ctggcgtgcc catcatgccc agcacctgag ttcctggggg      120

gaccatcagt cttcctgttc cccccaaaac ccaaggacac tctcatgatc tcccggaccc      180

ctgaggtcac gtgcgtggtg gtggacgtga gccaggaaga ccccgaggtc cagttcaact      240

ggtacgtgga tggcgtggag gtgcataatg ccaagacaaa gccgcgggag gagcagttca      300

acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg ctgaacggca      360

aggagtacaa gtgcaaggtc tccaacaaag gcctcccgtc ctccatcgag aaaaccatct      420

ccaaagccaa agggcagccc cgagagccac aggtgtacac cctgccccca tcccaggagg      480

agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctac cccagcgaca      540

tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc acgcctcccg      600

tgctggactc cgacggctcc ttcttcctct acagcaggct aaccgtggac aagagcaggt      660

ggcaggaggg gaatgtcttc tcatgctccg tgatgcatga ggctctgcac aaccactaca      720

cacagaagag cctctccctg tctctgggta aatgactcga gcggccg                    767


<210>  85
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having a IFN signal peptide

<400>  85

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Ser Cys Pro Ala Pro Glu Phe 
            20                  25                  30          


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
                85                  90                  95      


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
        115                 120                 125             


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Leu Gly Lys 
                245 


<210>  86
<211>  767
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having a IFN signal 
       peptide

<400>  86
aagcttgaat tcccaccatg gccttgacct ttgctttact ggtggccctc ctggtgctca       60

gctgcaagtc aagctgctct gtgggctgcc catcatgccc agcacctgag ttcctggggg      120

gaccatcagt cttcctgttc cccccaaaac ccaaggacac tctcatgatc tcccggaccc      180

ctgaggtcac gtgcgtggtg gtggacgtga gccaggaaga ccccgaggtc cagttcaact      240

ggtacgtgga tggcgtggag gtgcataatg ccaagacaaa gccgcgggag gagcagttca      300

acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg ctgaacggca      360

aggagtacaa gtgcaaggtc tccaacaaag gcctcccgtc ctccatcgag aaaaccatct      420

ccaaagccaa agggcagccc cgagagccac aggtgtacac cctgccccca tcccaggagg      480

agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctac cccagcgaca      540

tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc acgcctcccg      600

tgctggactc cgacggctcc ttcttcctct acagcaggct aaccgtggac aagagcaggt      660

ggcaggaggg gaatgtcttc tcatgctccg tgatgcatga ggctctgcac aaccactaca      720

cacagaagag cctctccctg tctctgggta aatgactcga gcggccg                    767


<210>  87
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having a CETP signal peptide

<400>  87

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
            20                  25                  30          


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        35                  40                  45              


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
    50                  55                  60                  


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
65                  70                  75                  80  


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
                85                  90                  95      


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            100                 105                 110         


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
        115                 120                 125             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    130                 135                 140                 


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
145                 150                 155                 160 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                165                 170                 175     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            180                 185                 190         


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
        195                 200                 205             


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    210                 215                 220                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
225                 230                 235                 


<210>  88
<211>  749
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having a CETP signal 
       peptide

<400>  88
aagcttgaat tcccaccatg ctggctgcca cagtcctgac cctggccctg ctgggcaatg       60

cccatgcctg cccatcatgc ccagcacctg agttcctggg gggaccatca gtcttcctgt      120

tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc acgtgcgtgg      180

tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg gatggcgtgg      240

aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg taccgtgtgg      300

tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac aagtgcaagg      360

tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc aaagggcagc      420

cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc aagaaccagg      480

tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg gagtgggaga      540

gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac tccgacggct      600

ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag gggaatgtct      660

tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag agcctctccc      720

tgtctctggg taaatgactc gagcggccg                                        749


<210>  89
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 Fc domain having the N-terminal sequence CPAPE

<400>  89

Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
1               5                   10                  15      


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            20                  25                  30          


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
        35                  40                  45              


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    50                  55                  60                  


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
65                  70                  75                  80  


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                85                  90                  95      


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
        115                 120                 125             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    130                 135                 140                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
145                 150                 155                 160 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                165                 170                 175     


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
            180                 185                 190         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        195                 200                 205             


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215                 


<210>  90
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding human IgG4 Fc domain having the N-terminal sequence 
       CPAPE

<400>  90
tgcccagcac ctgagttcct ggggggacca tcagtcttcc tgttcccccc aaaacccaag       60

gacactctca tgatctcccg gacccctgag gtcacgtgcg tggtggtgga cgtgagccag      120

gaagaccccg aggtccagtt caactggtac gtggatggcg tggaggtgca taatgccaag      180

acaaagccgc gggaggagca gttcaacagc acgtaccgtg tggtcagcgt cctcaccgtc      240

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtctccaa caaaggcctc      300

ccgtcctcca tcgagaaaac catctccaaa gccaaagggc agccccgaga gccacaggtg      360

tacaccctgc ccccatccca ggaggagatg accaagaacc aggtcagcct gacctgcctg      420

gtcaaaggct tctaccccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag      480

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc      540

aggctaaccg tggacaagag caggtggcag gaggggaatg tcttctcatg ctccgtgatg      600

catgaggctc tgcacaacca ctacacacag aagagcctct ccctgtctct gggtaaa         657


<210>  91
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having a SHH signal peptide

<400>  91

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Ala Pro Glu Phe Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
    50                  55                  60                  


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
65                  70                  75                  80  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            100                 105                 110         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
        115                 120                 125             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    130                 135                 140                 


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
145                 150                 155                 160 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                165                 170                 175     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            180                 185                 190         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
        195                 200                 205             


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
    210                 215                 220                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
225                 230                 235                 240 


Gly Lys 
        


<210>  92
<211>  758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having a SHH signal 
       peptide

<400>  92
aagcttgaat tcccaccatg ctgctgctgg cgagatgtct gctgctagtc ctcgtctcct       60

cgctgctggt atgctcggga ctggcgtgcc cagcacctga gttcctgggg ggaccatcag      120

tcttcctgtt ccccccaaaa cccaaggaca ctctcatgat ctcccggacc cctgaggtca      180

cgtgcgtggt ggtggacgtg agccaggaag accccgaggt ccagttcaac tggtacgtgg      240

atggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagttc aacagcacgt      300

accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc aaggagtaca      360

agtgcaaggt ctccaacaaa ggcctcccgt cctccatcga gaaaaccatc tccaaagcca      420

aagggcagcc ccgagagcca caggtgtaca ccctgccccc atcccaggag gagatgacca      480

agaaccaggt cagcctgacc tgcctggtca aaggcttcta ccccagcgac atcgccgtgg      540

agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc gtgctggact      600

ccgacggctc cttcttcctc tacagcaggc taaccgtgga caagagcagg tggcaggagg      660

ggaatgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac acacagaaga      720

gcctctccct gtctctgggt aaatgactcg agcggccg                              758


<210>  93
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having a IFN signal peptide

<400>  93

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Ala Pro Glu Phe Leu Gly Gly 
            20                  25                  30          


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        35                  40                  45              


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu 
    50                  55                  60                  


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
65                  70                  75                  80  


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg 
                85                  90                  95      


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            100                 105                 110         


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu 
        115                 120                 125             


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    130                 135                 140                 


Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
145                 150                 155                 160 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                165                 170                 175     


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            180                 185                 190         


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp 
        195                 200                 205             


Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His 
    210                 215                 220                 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu 
225                 230                 235                 240 


Gly Lys 
        


<210>  94
<211>  758
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having a IFN signal 
       peptide

<400>  94
aagcttgaat tcccaccatg gccttgacct ttgctttact ggtggccctc ctggtgctca       60

gctgcaagtc aagctgctct gtgggctgcc cagcacctga gttcctgggg ggaccatcag      120

tcttcctgtt ccccccaaaa cccaaggaca ctctcatgat ctcccggacc cctgaggtca      180

cgtgcgtggt ggtggacgtg agccaggaag accccgaggt ccagttcaac tggtacgtgg      240

atggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagttc aacagcacgt      300

accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc aaggagtaca      360

agtgcaaggt ctccaacaaa ggcctcccgt cctccatcga gaaaaccatc tccaaagcca      420

aagggcagcc ccgagagcca caggtgtaca ccctgccccc atcccaggag gagatgacca      480

agaaccaggt cagcctgacc tgcctggtca aaggcttcta ccccagcgac atcgccgtgg      540

agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc gtgctggact      600

ccgacggctc cttcttcctc tacagcaggc taaccgtgga caagagcagg tggcaggagg      660

ggaatgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac acacagaaga      720

gcctctccct gtctctgggt aaatgactcg agcggccg                              758


<210>  95
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc chimeric polypeptide having a CETP signal peptide

<400>  95

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe 
            20                  25                  30          


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        35                  40                  45              


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
    50                  55                  60                  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
65                  70                  75                  80  


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                85                  90                  95      


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            100                 105                 110         


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
        115                 120                 125             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
    130                 135                 140                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
145                 150                 155                 160 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                165                 170                 175     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            180                 185                 190         


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
        195                 200                 205             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    210                 215                 220                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
225                 230                 235     


<210>  96
<211>  740
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding pre-Fc chimeric polypeptide having a CETP signal 
       peptide

<400>  96
aagcttgaat tcccaccatg ctggctgcca cagtcctgac cctggccctg ctgggcaatg       60

cccatgcctg cccagcacct gagttcctgg ggggaccatc agtcttcctg ttccccccaa      120

aacccaagga cactctcatg atctcccgga cccctgaggt cacgtgcgtg gtggtggacg      180

tgagccagga agaccccgag gtccagttca actggtacgt ggatggcgtg gaggtgcata      240

atgccaagac aaagccgcgg gaggagcagt tcaacagcac gtaccgtgtg gtcagcgtcc      300

tcaccgtcct gcaccaggac tggctgaacg gcaaggagta caagtgcaag gtctccaaca      360

aaggcctccc gtcctccatc gagaaaacca tctccaaagc caaagggcag ccccgagagc      420

cacaggtgta caccctgccc ccatcccagg aggagatgac caagaaccag gtcagcctga      480

cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag agcaatgggc      540

agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc tccttcttcc      600

tctacagcag gctaaccgtg gacaagagca ggtggcagga ggggaatgtc ttctcatgct      660

ccgtgatgca tgaggctctg cacaaccact acacacagaa gagcctctcc ctgtctctgg      720

gtaaatgact cgagcggccg                                                  740


<210>  97
<211>  5428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDNA3.1(+)

<400>  97
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

gtttaaactt aagcttggta ccgagctcgg atccactagt ccagtgtggt ggaattctgc      960

agatatccag cacagtggcg gccgctcgag tctagagggc ccgtttaaac ccgctgatca     1020

gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc cgtgccttcc     1080

ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga aattgcatcg     1140

cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga cagcaagggg     1200

gaggattggg aagacaatag caggcatgct ggggatgcgg tgggctctat ggcttctgag     1260

gcggaaagaa ccagctgggg ctctaggggg tatccccacg cgccctgtag cggcgcatta     1320

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     1380

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     1440

gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc     1500

aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt     1560

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     1620

acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc     1680

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattaatt ctgtggaatg     1740

tgtgtcagtt agggtgtgga aagtccccag gctccccagc aggcagaagt atgcaaagca     1800

tgcatctcaa ttagtcagca accaggtgtg gaaagtcccc aggctcccca gcaggcagaa     1860

gtatgcaaag catgcatctc aattagtcag caaccatagt cccgccccta actccgccca     1920

tcccgcccct aactccgccc agttccgccc attctccgcc ccatggctga ctaatttttt     1980

ttatttatgc agaggccgag gccgcctctg cctctgagct attccagaag tagtgaggag     2040

gcttttttgg aggcctaggc ttttgcaaaa agctcccggg agcttgtata tccattttcg     2100

gatctgatca agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg     2160

caggttctcc ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa     2220

tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg     2280

tcaagaccga cctgtccggt gccctgaatg aactgcagga cgaggcagcg cggctatcgt     2340

ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa     2400

gggactggct gctattgggc gaagtgccgg ggcaggatct cctgtcatct caccttgctc     2460

ctgccgagaa agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg     2520

ctacctgccc attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg     2580

aagccggtct tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg     2640

aactgttcgc caggctcaag gcgcgcatgc ccgacggcga ggatctcgtc gtgacccatg     2700

gcgatgcctg cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact     2760

gtggccggct gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg     2820

ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc     2880

ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga gcgggactct     2940

ggggttcgaa atgaccgacc aagcgacgcc caacctgcca tcacgagatt tcgattccac     3000

cgccgccttc tatgaaaggt tgggcttcgg aatcgttttc cgggacgccg gctggatgat     3060

cctccagcgc ggggatctca tgctggagtt cttcgcccac cccaacttgt ttattgcagc     3120

ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc     3180

actgcattct agttgtggtt tgtccaaact catcaatgta tcttatcatg tctgtatacc     3240

gtcgacctct agctagagct tggcgtaatc atggtcatag ctgtttcctg tgtgaaattg     3300

ttatccgctc acaattccac acaacatacg agccggaagc ataaagtgta aagcctgggg     3360

tgcctaatga gtgagctaac tcacattaat tgcgttgcgc tcactgcccg ctttccagtc     3420

gggaaacctg tcgtgccagc tgcattaatg aatcggccaa cgcgcgggga gaggcggttt     3480

gcgtattggg cgctcttccg cttcctcgct cactgactcg ctgcgctcgg tcgttcggct     3540

gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg ttatccacag aatcagggga     3600

taacgcagga aagaacatgt gagcaaaagg ccagcaaaag gccaggaacc gtaaaaaggc     3660

cgcgttgctg gcgtttttcc ataggctccg cccccctgac gagcatcaca aaaatcgacg     3720

ctcaagtcag aggtggcgaa acccgacagg actataaaga taccaggcgt ttccccctgg     3780

aagctccctc gtgcgctctc ctgttccgac cctgccgctt accggatacc tgtccgcctt     3840

tctcccttcg ggaagcgtgg cgctttctca tagctcacgc tgtaggtatc tcagttcggt     3900

gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc cccgttcagc ccgaccgctg     3960

cgccttatcc ggtaactatc gtcttgagtc caacccggta agacacgact tatcgccact     4020

ggcagcagcc actggtaaca ggattagcag agcgaggtat gtaggcggtg ctacagagtt     4080

cttgaagtgg tggcctaact acggctacac tagaagaaca gtatttggta tctgcgctct     4140

gctgaagcca gttaccttcg gaaaaagagt tggtagctct tgatccggca aacaaaccac     4200

cgctggtagc ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca     4260

agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta     4320

agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa     4380

atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg     4440

cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg     4500

actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc     4560

aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc     4620

cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa     4680

ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc     4740

cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     4800

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     4860

cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat     4920

ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg     4980

tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc     5040

ggcgtcaata cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg     5100

aaaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat     5160

gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg     5220

gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg     5280

ttgaatactc atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct     5340

catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg ttccgcgcac     5400

atttccccga aaagtgccac ctgacgtc                                        5428


<210>  98
<211>  4195
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pSA

<400>  98
ctaaattgta agcgttaata ttttgttaaa attcgcgtta aatttttgtt aaatcagctc       60

attttttaac caataggccg aaatcggcaa aatcccttat aaatcaaaag aatagaccga      120

gatagggttg agtgttgttc cagtttggaa caagagtcca ctattaaaga acgtggactc      180

caacgtcaaa gggcgaaaaa ccgtctatca gggcgatggc ccactacgtg aaccatcacc      240

ctaatcaagt tttttggggt cgaggtgccg taaagcacta aatcggaacc ctaaagggag      300

cccccgattt agagcttgac ggggaaagcc ggcgaacgtg gcgagaaagg aagggaagaa      360

agcgaaagga gcgggcgcta gggcgctggc aagtgtagcg gtcacgctgc gcgtaaccac      420

cacacccgcc gcgcttaatg cgccgctaca gggcgcgtcc cattcgccat tcaggctgcg      480

caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc tggcgaaagg      540

gggatgtgct gcaaggcgat taagttgggt aacgccaggg ttttcccagt cacgacgttg      600

taaaacgacg gccagtgagc gcgcaagcgg ccgcaacccg ggaaaagctt ggccattgca      660

tacgttgtat ccatatcata atatgtacat ttatattggc tcatgtccaa cattaccgcc      720

atgttgacat tgattattga ctagttatta atagtaatca attacggggt cattagttca      780

tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc      840

gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat      900

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt      960

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc     1020

cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta     1080

cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg     1140

atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt     1200

gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac     1260

gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc gtttagtgaa     1320

ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa gacaccggga     1380

ccgatccagc ctccgcggcc gggaacggtg cattggaacg cggattcccc gtgccaagag     1440

tgacgtaagt accgcctata gagtctatag gcccaccccc ttggcttctt atgcatgctc     1500

ccctgctccg acccgggctc ctcgcccgcc cggacccaca ggccaccctc aaccgtcctg     1560

gccccggacc caaaccccac ccctcactct gcttctcccc gcaggagaat tcaatcgcga     1620

aagggcccaa agatctgcca taccacattt gtagaggttt tacttgcttt aaaaaacctc     1680

ccacacctcc ccctgaacct gaaacataaa atgaatgcaa ttgttgttgt taacttgttt     1740

attgcagctt ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca     1800

tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc     1860

tggagctagc atcccgcccc taactccgcc ctgttccgcc cattctccgc cccatggctg     1920

actaattttt tttatttatg cagaggccga ggccgcctcg gcctctgagc tattccagaa     1980

gtagtgagga ggcttttttg gaggcctagg cttttgcgtc gagaagcgcg cttggcgtaa     2040

tcatggtcat agctgtttcc tgtgtgaaat tgttatccgc tcacaattcc acacaacata     2100

cgagccggaa gcataaagtg taaagcctgg ggtgcctaat gagtgagcta actcacatta     2160

attgcgttgc gctcactgcc cgctttccag tcgggaaacc tgtcgtgcca gctgcattaa     2220

tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg ggcgctcttc cgcttcctcg     2280

ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag cggtatcagc tcactcaaag     2340

gcggtaatac ggttatccac agaatcaggg gataacgcag gaaagaacat gtgagcaaaa     2400

ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc tggcgttttt ccataggctc     2460

cgcccccctg acgagcatca caaaaatcga cgctcaagtc agaggtggcg aaacccgaca     2520

ggactataaa gataccaggc gtttccccct ggaagctccc tcgtgcgctc tcctgttccg     2580

accctgccgc ttaccggata cctgtccgcc tttctccctt cgggaagcgt ggcgctttct     2640

catagctcac gctgtaggta tctcagttcg gtgtaggtcg ttcgctccaa gctgggctgt     2700

gtgcacgaac cccccgttca gcccgaccgc tgcgccttat ccggtaacta tcgtcttgag     2760

tccaacccgg taagacacga cttatcgcca ctggcagcag ccactggtaa caggattagc     2820

agagcgaggt atgtaggcgg tgctacagag ttcttgaagt ggtggcctaa ctacggctac     2880

actagaagga cagtatttgg tatctgcgct ctgctgaagc cagttacctt cggaaaaaga     2940

gttggtagct cttgatccgg caaacaaacc accgctggta gcggtggttt ttttgtttgc     3000

aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag atcctttgat cttttctacg     3060

gggtctgacg ctcagtggaa cgaaaactca cgttaaggga ttttggtcat gagattatca     3120

aaaaggatct tcacctagat ccttttaaat taaaaatgaa gttttaaatc aatctaaagt     3180

atatatgagt aaacttggtc tgacagttac caatgcttaa tcagtgaggc acctatctca     3240

gcgatctgtc tatttcgttc atccatagtt gcctgactcc ccgtcgtgta gataactacg     3300

atacgggagg gcttaccatc tggccccagt gctgcaatga taccgcgaga cccacgctca     3360

ccggctccag atttatcagc aataaaccag ccagccggaa gggccgagcg cagaagtggt     3420

cctgcaactt tatccgcctc catccagtct attaattgtt gccgggaagc tagagtaagt     3480

agttcgccag ttaatagttt gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca     3540

cgctcgtcgt ttggtatggc ttcattcagc tccggttccc aacgatcaag gcgagttaca     3600

tgatccccca tgttgtgcaa aaaagcggtt agctccttcg gtcctccgat cgttgtcaga     3660

agtaagttgg ccgcagtgtt atcactcatg gttatggcag cactgcataa ttctcttact     3720

gtcatgccat ccgtaagatg cttttctgtg actggtgagt actcaaccaa gtcattctga     3780

gaatagtgta tgcggcgacc gagttgctct tgcccggcgt caatacggga taataccgcg     3840

ccacatagca gaactttaaa agtgctcatc attggaaaac gttcttcggg gcgaaaactc     3900

tcaaggatct taccgctgtt gagatccagt tcgatgtaac ccactcgtgc acccaactga     3960

tcttcagcat cttttacttt caccagcgtt tctgggtgag caaaaacagg aaggcaaaat     4020

gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa tactcatact cttccttttt     4080

caatattatt gaagcattta tcagggttat tgtctcatga gcggatacat atttgaatgt     4140

atttagaaaa ataaacaaat aggggttccg cgcacatttc cccgaaaagt gccac          4195


<210>  99
<211>  824
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Construct

<400>  99
gttaacgaat tcccaccatg attgaacaag atggattgca cgcaggttct ccggccgctt       60

gggtggagag gctattcggc tatgactggg cacaacagac aatcggctgc tctgatgccg      120

ccgtgttccg gctgtcagcg caggggcgcc cggttctttt tgtcaagacc gacctgtccg      180

gtgccctgaa tgaactgcag gacgaggcag cgcggctatc gtggctggcc acgacgggcg      240

ttccttgcgc agctgtgctc gacgttgtca ctgaagcggg aagggactgg ctgctattgg      300

gcgaagtgcc ggggcaggat ctcctgtcat ctcaccttgc tcctgccgag aaagtatcca      360

tcatggctga tgcaatgcgg cggctgcata cgcttgatcc ggctacctgc ccattcgacc      420

accaagcgaa acatcgcatc gagcgagcac gtactcggat ggaagccggt cttgtcgatc      480

aggatgatct ggacgaagag catcaggggc tcgcgccagc cgaactgttc gccaggctca      540

aggcgcgcat gcccgacggc gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga      600

atatcatggt ggaaaatggc cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg      660

cggaccgcta tcaggacata gcgttggcta cccgtgatat tgctgaagag cttggcggcg      720

aatgggctga ccgcttcctc gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg      780

ccttctatcg ccttcttgac gagttcttct gaagatctgt taac                       824


<210>  100
<211>  6739
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDNA3-TNR1B-Mth

<400>  100
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

gtttaaactt aagcttgaat tcccaccatg gcgcccgtcg ccgtctgggc cgcgctggcc      960

gtcggactgg agctctgggc tgcggcgcac gccttgcccg cccaggtggc atttacaccc     1020

tacgccccgg agcccgggag cacatgccgg ctcagagaat actatgacca gacagctcag     1080

atgtgctgca gcaaatgctc gccgggccaa catgcaaaag tcttctgtac caagacctcg     1140

gacaccgtgt gtgactcctg tgaggacagc acatacaccc agctctggaa ctgggttccc     1200

gagtgcttga gctgtggctc ccgctgtagc tctgaccagg tggaaactca agcctgcact     1260

cgggaacaga accgcatctg cacctgcagg cccggctggt actgcgcgct gagcaagcag     1320

gaggggtgcc ggctgtgcgc gccgctgcgc aagtgccgcc cgggcttcgg cgtggccaga     1380

ccaggaactg aaacatcaga cgtggtgtgc aagccctgtg ccccggggac gttctccaac     1440

acgacttcat ccacggatat ttgcaggccc caccagatct gtaacgtggt ggccatccct     1500

gggaatgcaa gcatggatgc agtctgcacg tccacgtccc ccacccggag tatggcccca     1560

ggggcagtac acttacccca gccagtgtcc acacgatccc aacacacgca gccaactcca     1620

gaacccagca ctgctccaag cacctccttc ctgctcccaa tggggcccag ccccccagct     1680

gaagggagca ctggcgacgg gtgcgtatcc ggtgacacca ttgtaatgac tagtggcggg     1740

ccccgcactg tggctgaact ggagggcaaa ccgttcaccg cactgattcg cggctctggc     1800

tacccatgcc cctcaggttt cttccgcacc tgtgaacgtg acgtatatga tctgcgtaca     1860

cgtgagggtc attgcttacg tttgacccat gatcaccgtg ttctggtgat ggatggtggc     1920

ctggaatggc gtgccgcggg tgaactggaa cgcggcgacc gcctggtgat ggatgatgca     1980

gctggcgagt ttccggcact ggcaaccttc cgtggcctgc gtggcgctgg ccgccaggat     2040

gtttatgacg ctactgttta cggtgctagc gcattcactg ctaatggctt cattgtacac     2100

gcatgtggcg agcagcccgg gaccggtctg aactcaggcc tcacgacaaa tcctggtgta     2160

tccgcttggc aggtcaacac agcttatact gcgggacaat tggtcacata taacggcaag     2220

acgtataaat gtttgcagcc ccacacctcc ttggcaggat gggaaccatc caacgttcct     2280

gccttgtggc agcttcaatg actcgagcgg cccgtttaaa cccgctgatc agcctcgact     2340

gtgccttcta gttgccagcc atctgttgtt tgcccctccc ccgtgccttc cttgaccctg     2400

gaaggtgcca ctcccactgt cctttcctaa taaaatgagg aaattgcatc gcattgtctg     2460

agtaggtgtc attctattct ggggggtggg gtggggcagg acagcaaggg ggaggattgg     2520

gaagacaata gcaggcatgc tggggatgcg gtgggctcta tggcttctga ggcggaaaga     2580

accagctggg gctctagggg gtatccccac gcgccctgta gcggcgcatt aagcgcggcg     2640

ggtgtggtgg ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct     2700

ttcgctttct tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat     2760

cgggggctcc ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt     2820

gattagggtg atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg     2880

acgttggagt ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac     2940

cctatctcgg tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta     3000

aaaaatgagc tgatttaaca aaaatttaac gcgaattaat tctgtggaat gtgtgtcagt     3060

tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca     3120

attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga agtatgcaaa     3180

gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc atcccgcccc     3240

taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt tttatttatg     3300

cagaggccga ggccgcctct gcctctgagc tattccagaa gtagtgagga ggcttttttg     3360

gaggcctagg cttttgcaaa aagctcccgg gagcttgtat atccattttc ggatctgatc     3420

aagagacagg atgaggatcg tttcgcatga ttgaacaaga tggattgcac gcaggttctc     3480

cggccgcttg ggtggagagg ctattcggct atgactgggc acaacagaca atcggctgct     3540

ctgatgccgc cgtgttccgg ctgtcagcgc aggggcgccc ggttcttttt gtcaagaccg     3600

acctgtccgg tgccctgaat gaactgcagg acgaggcagc gcggctatcg tggctggcca     3660

cgacgggcgt tccttgcgca gctgtgctcg acgttgtcac tgaagcggga agggactggc     3720

tgctattggg cgaagtgccg gggcaggatc tcctgtcatc tcaccttgct cctgccgaga     3780

aagtatccat catggctgat gcaatgcggc ggctgcatac gcttgatccg gctacctgcc     3840

cattcgacca ccaagcgaaa catcgcatcg agcgagcacg tactcggatg gaagccggtc     3900

ttgtcgatca ggatgatctg gacgaagagc atcaggggct cgcgccagcc gaactgttcg     3960

ccaggctcaa ggcgcgcatg cccgacggcg aggatctcgt cgtgacccat ggcgatgcct     4020

gcttgccgaa tatcatggtg gaaaatggcc gcttttctgg attcatcgac tgtggccggc     4080

tgggtgtggc ggaccgctat caggacatag cgttggctac ccgtgatatt gctgaagagc     4140

ttggcggcga atgggctgac cgcttcctcg tgctttacgg tatcgccgct cccgattcgc     4200

agcgcatcgc cttctatcgc cttcttgacg agttcttctg agcgggactc tggggttcga     4260

aatgaccgac caagcgacgc ccaacctgcc atcacgagat ttcgattcca ccgccgcctt     4320

ctatgaaagg ttgggcttcg gaatcgtttt ccgggacgcc ggctggatga tcctccagcg     4380

cggggatctc atgctggagt tcttcgccca ccccaacttg tttattgcag cttataatgg     4440

ttacaaataa agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc     4500

tagttgtggt ttgtccaaac tcatcaatgt atcttatcat gtctgtatac cgtcgacctc     4560

tagctagagc ttggcgtaat catggtcata gctgtttcct gtgtgaaatt gttatccgct     4620

cacaattcca cacaacatac gagccggaag cataaagtgt aaagcctggg gtgcctaatg     4680

agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc gctttccagt cgggaaacct     4740

gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg     4800

gcgctcttcc gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc     4860

ggtatcagct cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg     4920

aaagaacatg tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct     4980

ggcgtttttc cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca     5040

gaggtggcga aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct     5100

cgtgcgctct cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc     5160

gggaagcgtg gcgctttctc atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt     5220

tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc     5280

cggtaactat cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc     5340

cactggtaac aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg     5400

gtggcctaac tacggctaca ctagaagaac agtatttggt atctgcgctc tgctgaagcc     5460

agttaccttc ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag     5520

cggttttttt gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc     5580

tttgatcttt tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt     5640

ggtcatgaga ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt     5700

taaatcaatc taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag     5760

tgaggcacct atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt     5820

cgtgtagata actacgatac gggagggctt accatctggc cccagtgctg caatgatacc     5880

gcgagaccca cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc     5940

cgagcgcaga agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg     6000

ggaagctaga gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac     6060

aggcatcgtg gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg     6120

atcaaggcga gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc     6180

tccgatcgtt gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact     6240

gcataattct cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc     6300

aaccaagtca ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat     6360

acgggataat accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc     6420

ttcggggcga aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac     6480

tcgtgcaccc aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa     6540

aacaggaagg caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact     6600

catactcttc ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg     6660

atacatattt gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg     6720

aaaagtgcca cctgacgtc                                                  6739


<210>  101
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-TNR1B-intein chimeric polypeptide

<400>  101

Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu 
1               5                   10                  15      


Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp Gly Cys Val Ser Gly Asp Thr Ile Val Met Thr Ser Gly Gly Pro 
            260                 265                 270         


Arg Thr Val Ala Glu Leu Glu Gly Lys Pro Phe Thr Ala Leu Ile Arg 
        275                 280                 285             


Gly Ser Gly Tyr Pro Cys Pro Ser Gly Phe Phe Arg Thr Cys Glu Arg 
    290                 295                 300                 


Asp Val Tyr Asp Leu Arg Thr Arg Glu Gly His Cys Leu Arg Leu Thr 
305                 310                 315                 320 


His Asp His Arg Val Leu Val Met Asp Gly Gly Leu Glu Trp Arg Ala 
                325                 330                 335     


Ala Gly Glu Leu Glu Arg Gly Asp Arg Leu Val Met Asp Asp Ala Ala 
            340                 345                 350         


Gly Glu Phe Pro Ala Leu Ala Thr Phe Arg Gly Leu Arg Gly Ala Gly 
        355                 360                 365             


Arg Gln Asp Val Tyr Asp Ala Thr Val Tyr Gly Ala Ser Ala Phe Thr 
    370                 375                 380                 


Ala Asn Gly Phe Ile Val His Ala Cys Gly Glu Gln Pro Gly Thr Gly 
385                 390                 395                 400 


Leu Asn Ser Gly Leu Thr Thr Asn Pro Gly Val Ser Ala Trp Gln Val 
                405                 410                 415     


Asn Thr Ala Tyr Thr Ala Gly Gln Leu Val Thr Tyr Asn Gly Lys Thr 
            420                 425                 430         


Tyr Lys Cys Leu Gln Pro His Thr Ser Leu Ala Gly Trp Glu Pro Ser 
        435                 440                 445             


Asn Val Pro Ala Leu Trp Gln Leu Gln 
    450                 455         


<210>  102
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mature TNR1B-intein fusion protein

<400>  102

Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr Ala Pro Glu Pro Gly Ser 
1               5                   10                  15      


Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln Thr Ala Gln Met Cys Cys 
            20                  25                  30          


Ser Lys Cys Ser Pro Gly Gln His Ala Lys Val Phe Cys Thr Lys Thr 
        35                  40                  45              


Ser Asp Thr Val Cys Asp Ser Cys Glu Asp Ser Thr Tyr Thr Gln Leu 
    50                  55                  60                  


Trp Asn Trp Val Pro Glu Cys Leu Ser Cys Gly Ser Arg Cys Ser Ser 
65                  70                  75                  80  


Asp Gln Val Glu Thr Gln Ala Cys Thr Arg Glu Gln Asn Arg Ile Cys 
                85                  90                  95      


Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu Ser Lys Gln Glu Gly Cys 
            100                 105                 110         


Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg Pro Gly Phe Gly Val Ala 
        115                 120                 125             


Arg Pro Gly Thr Glu Thr Ser Asp Val Val Cys Lys Pro Cys Ala Pro 
    130                 135                 140                 


Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr Asp Ile Cys Arg Pro His 
145                 150                 155                 160 


Gln Ile Cys Asn Val Val Ala Ile Pro Gly Asn Ala Ser Met Asp Ala 
                165                 170                 175     


Val Cys Thr Ser Thr Ser Pro Thr Arg Ser Met Ala Pro Gly Ala Val 
            180                 185                 190         


His Leu Pro Gln Pro Val Ser Thr Arg Ser Gln His Thr Gln Pro Thr 
        195                 200                 205             


Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser Phe Leu Leu Pro Met Gly 
    210                 215                 220                 


Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly Asp Gly Cys Val Ser Gly 
225                 230                 235                 240 


Asp Thr Ile Val Met Thr Ser Gly Gly Pro Arg Thr Val Ala Glu Leu 
                245                 250                 255     


Glu Gly Lys Pro Phe Thr Ala Leu Ile Arg Gly Ser Gly Tyr Pro Cys 
            260                 265                 270         


Pro Ser Gly Phe Phe Arg Thr Cys Glu Arg Asp Val Tyr Asp Leu Arg 
        275                 280                 285             


Thr Arg Glu Gly His Cys Leu Arg Leu Thr His Asp His Arg Val Leu 
    290                 295                 300                 


Val Met Asp Gly Gly Leu Glu Trp Arg Ala Ala Gly Glu Leu Glu Arg 
305                 310                 315                 320 


Gly Asp Arg Leu Val Met Asp Asp Ala Ala Gly Glu Phe Pro Ala Leu 
                325                 330                 335     


Ala Thr Phe Arg Gly Leu Arg Gly Ala Gly Arg Gln Asp Val Tyr Asp 
            340                 345                 350         


Ala Thr Val Tyr Gly Ala Ser Ala Phe Thr Ala Asn Gly Phe Ile Val 
        355                 360                 365             


His Ala Cys Gly Glu Gln Pro Gly Thr Gly Leu Asn Ser Gly Leu Thr 
    370                 375                 380                 


Thr Asn Pro Gly Val Ser Ala Trp Gln Val Asn Thr Ala Tyr Thr Ala 
385                 390                 395                 400 


Gly Gln Leu Val Thr Tyr Asn Gly Lys Thr Tyr Lys Cys Leu Gln Pro 
                405                 410                 415     


His Thr Ser Leu Ala Gly Trp Glu Pro Ser Asn Val Pro Ala Leu Trp 
            420                 425                 430         


Gln Leu Gln 
        435 


<210>  103
<211>  6103
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCDNA3-SHH-IgG1-Fc11

<400>  103
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

gtttaaactt aagcttgaat tcccaccatg ctgctgctgg cgagatgtct gctgctagtc      960

ctcgtctcct cgctgctggt atgctcggga ctggcgtgcc caccgtgccc agcacctgaa     1020

ctcctggggg ggccctcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     1080

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     1140

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     1200

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1260

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1320

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1380

tcccgggatg agctgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1440

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1500

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1560

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1620

aaccactaca cgcagaagag cctctccctg tctccgggta aatgactcga gcggcccgtt     1680

taaacccgct gatcagcctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc     1740

tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat     1800

gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg     1860

caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga tgcggtgggc     1920

tctatggctt ctgaggcgga aagaaccagc tggggctcta gggggtatcc ccacgcgccc     1980

tgtagcggcg cattaagcgc ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt     2040

gccagcgccc tagcgcccgc tcctttcgct ttcttccctt cctttctcgc cacgttcgcc     2100

ggctttcccc gtcaagctct aaatcggggg ctccctttag ggttccgatt tagtgcttta     2160

cggcacctcg accccaaaaa acttgattag ggtgatggtt cacgtagtgg gccatcgccc     2220

tgatagacgg tttttcgccc tttgacgttg gagtccacgt tctttaatag tggactcttg     2280

ttccaaactg gaacaacact caaccctatc tcggtctatt cttttgattt ataagggatt     2340

ttgccgattt cggcctattg gttaaaaaat gagctgattt aacaaaaatt taacgcgaat     2400

taattctgtg gaatgtgtgt cagttagggt gtggaaagtc cccaggctcc ccagcaggca     2460

gaagtatgca aagcatgcat ctcaattagt cagcaaccag gtgtggaaag tccccaggct     2520

ccccagcagg cagaagtatg caaagcatgc atctcaatta gtcagcaacc atagtcccgc     2580

ccctaactcc gcccatcccg cccctaactc cgcccagttc cgcccattct ccgccccatg     2640

gctgactaat tttttttatt tatgcagagg ccgaggccgc ctctgcctct gagctattcc     2700

agaagtagtg aggaggcttt tttggaggcc taggcttttg caaaaagctc ccgggagctt     2760

gtatatccat tttcggatct gatcaagaga caggatgagg atcgtttcgc atgattgaac     2820

aagatggatt gcacgcaggt tctccggccg cttgggtgga gaggctattc ggctatgact     2880

gggcacaaca gacaatcggc tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc     2940

gcccggttct ttttgtcaag accgacctgt ccggtgccct gaatgaactg caggacgagg     3000

cagcgcggct atcgtggctg gccacgacgg gcgttccttg cgcagctgtg ctcgacgttg     3060

tcactgaagc gggaagggac tggctgctat tgggcgaagt gccggggcag gatctcctgt     3120

catctcacct tgctcctgcc gagaaagtat ccatcatggc tgatgcaatg cggcggctgc     3180

atacgcttga tccggctacc tgcccattcg accaccaagc gaaacatcgc atcgagcgag     3240

cacgtactcg gatggaagcc ggtcttgtcg atcaggatga tctggacgaa gagcatcagg     3300

ggctcgcgcc agccgaactg ttcgccaggc tcaaggcgcg catgcccgac ggcgaggatc     3360

tcgtcgtgac ccatggcgat gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt     3420

ctggattcat cgactgtggc cggctgggtg tggcggaccg ctatcaggac atagcgttgg     3480

ctacccgtga tattgctgaa gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt     3540

acggtatcgc cgctcccgat tcgcagcgca tcgccttcta tcgccttctt gacgagttct     3600

tctgagcggg actctggggt tcgaaatgac cgaccaagcg acgcccaacc tgccatcacg     3660

agatttcgat tccaccgccg ccttctatga aaggttgggc ttcggaatcg ttttccggga     3720

cgccggctgg atgatcctcc agcgcgggga tctcatgctg gagttcttcg cccaccccaa     3780

cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa     3840

taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta     3900

tcatgtctgt ataccgtcga cctctagcta gagcttggcg taatcatggt catagctgtt     3960

tcctgtgtga aattgttatc cgctcacaat tccacacaac atacgagccg gaagcataaa     4020

gtgtaaagcc tggggtgcct aatgagtgag ctaactcaca ttaattgcgt tgcgctcact     4080

gcccgctttc cagtcgggaa acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc     4140

ggggagaggc ggtttgcgta ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg     4200

ctcggtcgtt cggctgcggc gagcggtatc agctcactca aaggcggtaa tacggttatc     4260

cacagaatca ggggataacg caggaaagaa catgtgagca aaaggccagc aaaaggccag     4320

gaaccgtaaa aaggccgcgt tgctggcgtt tttccatagg ctccgccccc ctgacgagca     4380

tcacaaaaat cgacgctcaa gtcagaggtg gcgaaacccg acaggactat aaagatacca     4440

ggcgtttccc cctggaagct ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg     4500

atacctgtcc gcctttctcc cttcgggaag cgtggcgctt tctcatagct cacgctgtag     4560

gtatctcagt tcggtgtagg tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt     4620

tcagcccgac cgctgcgcct tatccggtaa ctatcgtctt gagtccaacc cggtaagaca     4680

cgacttatcg ccactggcag cagccactgg taacaggatt agcagagcga ggtatgtagg     4740

cggtgctaca gagttcttga agtggtggcc taactacggc tacactagaa gaacagtatt     4800

tggtatctgc gctctgctga agccagttac cttcggaaaa agagttggta gctcttgatc     4860

cggcaaacaa accaccgctg gtagcggttt ttttgtttgc aagcagcaga ttacgcgcag     4920

aaaaaaagga tctcaagaag atcctttgat cttttctacg gggtctgacg ctcagtggaa     4980

cgaaaactca cgttaaggga ttttggtcat gagattatca aaaaggatct tcacctagat     5040

ccttttaaat taaaaatgaa gttttaaatc aatctaaagt atatatgagt aaacttggtc     5100

tgacagttac caatgcttaa tcagtgaggc acctatctca gcgatctgtc tatttcgttc     5160

atccatagtt gcctgactcc ccgtcgtgta gataactacg atacgggagg gcttaccatc     5220

tggccccagt gctgcaatga taccgcgaga cccacgctca ccggctccag atttatcagc     5280

aataaaccag ccagccggaa gggccgagcg cagaagtggt cctgcaactt tatccgcctc     5340

catccagtct attaattgtt gccgggaagc tagagtaagt agttcgccag ttaatagttt     5400

gcgcaacgtt gttgccattg ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc     5460

ttcattcagc tccggttccc aacgatcaag gcgagttaca tgatccccca tgttgtgcaa     5520

aaaagcggtt agctccttcg gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt     5580

atcactcatg gttatggcag cactgcataa ttctcttact gtcatgccat ccgtaagatg     5640

cttttctgtg actggtgagt actcaaccaa gtcattctga gaatagtgta tgcggcgacc     5700

gagttgctct tgcccggcgt caatacggga taataccgcg ccacatagca gaactttaaa     5760

agtgctcatc attggaaaac gttcttcggg gcgaaaactc tcaaggatct taccgctgtt     5820

gagatccagt tcgatgtaac ccactcgtgc acccaactga tcttcagcat cttttacttt     5880

caccagcgtt tctgggtgag caaaaacagg aaggcaaaat gccgcaaaaa agggaataag     5940

ggcgacacgg aaatgttgaa tactcatact cttccttttt caatattatt gaagcattta     6000

tcagggttat tgtctcatga gcggatacat atttgaatgt atttagaaaa ataaacaaat     6060

aggggttccg cgcacatttc cccgaaaagt gccacctgac gtc                       6103


<210>  104
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-Fc6 polypeptide

<400>  104

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            20                  25                  30          


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        35                  40                  45              


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    50                  55                  60                  


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
65                  70                  75                  80  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                85                  90                  95      


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            100                 105                 110         


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        115                 120                 125             


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    130                 135                 140                 


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
145                 150                 155                 160 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                165                 170                 175     


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            180                 185                 190         


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        195                 200                 205             


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    210                 215                 220                 


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
225                 230                 235                 240 


Leu Ser Pro Gly Lys 
                245 


<210>  105
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mature Fc6 protein

<400>  105

Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
1               5                   10                  15      


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            20                  25                  30          


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        35                  40                  45              


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    50                  55                  60                  


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
65                  70                  75                  80  


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                85                  90                  95      


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            100                 105                 110         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        115                 120                 125             


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    130                 135                 140                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
145                 150                 155                 160 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                165                 170                 175     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            180                 185                 190         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        195                 200                 205             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220         


<210>  106
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cleaved alkyne-modified TNR1B


<220>
<221>  SITE
<222>  (237)..(237)
<223>  Xaa = cysteine-alkyne

<400>  106

Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr Ala Pro Glu Pro Gly Ser 
1               5                   10                  15      


Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln Thr Ala Gln Met Cys Cys 
            20                  25                  30          


Ser Lys Cys Ser Pro Gly Gln His Ala Lys Val Phe Cys Thr Lys Thr 
        35                  40                  45              


Ser Asp Thr Val Cys Asp Ser Cys Glu Asp Ser Thr Tyr Thr Gln Leu 
    50                  55                  60                  


Trp Asn Trp Val Pro Glu Cys Leu Ser Cys Gly Ser Arg Cys Ser Ser 
65                  70                  75                  80  


Asp Gln Val Glu Thr Gln Ala Cys Thr Arg Glu Gln Asn Arg Ile Cys 
                85                  90                  95      


Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu Ser Lys Gln Glu Gly Cys 
            100                 105                 110         


Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg Pro Gly Phe Gly Val Ala 
        115                 120                 125             


Arg Pro Gly Thr Glu Thr Ser Asp Val Val Cys Lys Pro Cys Ala Pro 
    130                 135                 140                 


Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr Asp Ile Cys Arg Pro His 
145                 150                 155                 160 


Gln Ile Cys Asn Val Val Ala Ile Pro Gly Asn Ala Ser Met Asp Ala 
                165                 170                 175     


Val Cys Thr Ser Thr Ser Pro Thr Arg Ser Met Ala Pro Gly Ala Val 
            180                 185                 190         


His Leu Pro Gln Pro Val Ser Thr Arg Ser Gln His Thr Gln Pro Thr 
        195                 200                 205             


Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser Phe Leu Leu Pro Met Gly 
    210                 215                 220                 


Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly Asp Gly Xaa 
225                 230                 235         


<210>  107
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  azide-modified TNR1B protein


<220>
<221>  SITE
<222>  (237)..(237)
<223>  Xaa = cysteine-azide

<400>  107

Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr Ala Pro Glu Pro Gly Ser 
1               5                   10                  15      


Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln Thr Ala Gln Met Cys Cys 
            20                  25                  30          


Ser Lys Cys Ser Pro Gly Gln His Ala Lys Val Phe Cys Thr Lys Thr 
        35                  40                  45              


Ser Asp Thr Val Cys Asp Ser Cys Glu Asp Ser Thr Tyr Thr Gln Leu 
    50                  55                  60                  


Trp Asn Trp Val Pro Glu Cys Leu Ser Cys Gly Ser Arg Cys Ser Ser 
65                  70                  75                  80  


Asp Gln Val Glu Thr Gln Ala Cys Thr Arg Glu Gln Asn Arg Ile Cys 
                85                  90                  95      


Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu Ser Lys Gln Glu Gly Cys 
            100                 105                 110         


Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg Pro Gly Phe Gly Val Ala 
        115                 120                 125             


Arg Pro Gly Thr Glu Thr Ser Asp Val Val Cys Lys Pro Cys Ala Pro 
    130                 135                 140                 


Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr Asp Ile Cys Arg Pro His 
145                 150                 155                 160 


Gln Ile Cys Asn Val Val Ala Ile Pro Gly Asn Ala Ser Met Asp Ala 
                165                 170                 175     


Val Cys Thr Ser Thr Ser Pro Thr Arg Ser Met Ala Pro Gly Ala Val 
            180                 185                 190         


His Leu Pro Gln Pro Val Ser Thr Arg Ser Gln His Thr Gln Pro Thr 
        195                 200                 205             


Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser Phe Leu Leu Pro Met Gly 
    210                 215                 220                 


Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly Asp Gly Xaa 
225                 230                 235         


<210>  108
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  cysteine-modified TNR1B

<400>  108

Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr Ala Pro Glu Pro Gly Ser 
1               5                   10                  15      


Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln Thr Ala Gln Met Cys Cys 
            20                  25                  30          


Ser Lys Cys Ser Pro Gly Gln His Ala Lys Val Phe Cys Thr Lys Thr 
        35                  40                  45              


Ser Asp Thr Val Cys Asp Ser Cys Glu Asp Ser Thr Tyr Thr Gln Leu 
    50                  55                  60                  


Trp Asn Trp Val Pro Glu Cys Leu Ser Cys Gly Ser Arg Cys Ser Ser 
65                  70                  75                  80  


Asp Gln Val Glu Thr Gln Ala Cys Thr Arg Glu Gln Asn Arg Ile Cys 
                85                  90                  95      


Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu Ser Lys Gln Glu Gly Cys 
            100                 105                 110         


Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg Pro Gly Phe Gly Val Ala 
        115                 120                 125             


Arg Pro Gly Thr Glu Thr Ser Asp Val Val Cys Lys Pro Cys Ala Pro 
    130                 135                 140                 


Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr Asp Ile Cys Arg Pro His 
145                 150                 155                 160 


Gln Ile Cys Asn Val Val Ala Ile Pro Gly Asn Ala Ser Met Asp Ala 
                165                 170                 175     


Val Cys Thr Ser Thr Ser Pro Thr Arg Ser Met Ala Pro Gly Ala Val 
            180                 185                 190         


His Leu Pro Gln Pro Val Ser Thr Arg Ser Gln His Thr Gln Pro Thr 
        195                 200                 205             


Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser Phe Leu Leu Pro Met Gly 
    210                 215                 220                 


Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly Asp Gly Cys 
225                 230                 235         


<210>  109
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  thioester-modified TNR1B


<220>
<221>  SITE
<222>  (236)..(236)
<223>  Xaa = glycine-thioester

<400>  109

Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr Ala Pro Glu Pro Gly Ser 
1               5                   10                  15      


Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln Thr Ala Gln Met Cys Cys 
            20                  25                  30          


Ser Lys Cys Ser Pro Gly Gln His Ala Lys Val Phe Cys Thr Lys Thr 
        35                  40                  45              


Ser Asp Thr Val Cys Asp Ser Cys Glu Asp Ser Thr Tyr Thr Gln Leu 
    50                  55                  60                  


Trp Asn Trp Val Pro Glu Cys Leu Ser Cys Gly Ser Arg Cys Ser Ser 
65                  70                  75                  80  


Asp Gln Val Glu Thr Gln Ala Cys Thr Arg Glu Gln Asn Arg Ile Cys 
                85                  90                  95      


Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu Ser Lys Gln Glu Gly Cys 
            100                 105                 110         


Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg Pro Gly Phe Gly Val Ala 
        115                 120                 125             


Arg Pro Gly Thr Glu Thr Ser Asp Val Val Cys Lys Pro Cys Ala Pro 
    130                 135                 140                 


Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr Asp Ile Cys Arg Pro His 
145                 150                 155                 160 


Gln Ile Cys Asn Val Val Ala Ile Pro Gly Asn Ala Ser Met Asp Ala 
                165                 170                 175     


Val Cys Thr Ser Thr Ser Pro Thr Arg Ser Met Ala Pro Gly Ala Val 
            180                 185                 190         


His Leu Pro Gln Pro Val Ser Thr Arg Ser Gln His Thr Gln Pro Thr 
        195                 200                 205             


Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser Phe Leu Leu Pro Met Gly 
    210                 215                 220                 


Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly Asp Xaa 
225                 230                 235     


<210>  110
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Az-DKTHT-Fc6 protein


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Xaa = azide-aspartic acid

<400>  110

Xaa Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  111
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Az-PEG4-DKTHT-Fc6


<220>
<221>  SITE
<222>  (1)..(1)
<223>  Xaa = azide-PEG4-aspartic acid

<400>  111

Xaa Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  112
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide with internal non-peptidyl moiety. 
       TNR1B-alkyne-azide-Fc6


<220>
<221>  SITE
<222>  (238)..(238)
<223>  Xaa = non-peptidyl moiety

<400>  112

Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr Ala Pro Glu Pro Gly Ser 
1               5                   10                  15      


Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln Thr Ala Gln Met Cys Cys 
            20                  25                  30          


Ser Lys Cys Ser Pro Gly Gln His Ala Lys Val Phe Cys Thr Lys Thr 
        35                  40                  45              


Ser Asp Thr Val Cys Asp Ser Cys Glu Asp Ser Thr Tyr Thr Gln Leu 
    50                  55                  60                  


Trp Asn Trp Val Pro Glu Cys Leu Ser Cys Gly Ser Arg Cys Ser Ser 
65                  70                  75                  80  


Asp Gln Val Glu Thr Gln Ala Cys Thr Arg Glu Gln Asn Arg Ile Cys 
                85                  90                  95      


Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu Ser Lys Gln Glu Gly Cys 
            100                 105                 110         


Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg Pro Gly Phe Gly Val Ala 
        115                 120                 125             


Arg Pro Gly Thr Glu Thr Ser Asp Val Val Cys Lys Pro Cys Ala Pro 
    130                 135                 140                 


Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr Asp Ile Cys Arg Pro His 
145                 150                 155                 160 


Gln Ile Cys Asn Val Val Ala Ile Pro Gly Asn Ala Ser Met Asp Ala 
                165                 170                 175     


Val Cys Thr Ser Thr Ser Pro Thr Arg Ser Met Ala Pro Gly Ala Val 
            180                 185                 190         


His Leu Pro Gln Pro Val Ser Thr Arg Ser Gln His Thr Gln Pro Thr 
        195                 200                 205             


Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser Phe Leu Leu Pro Met Gly 
    210                 215                 220                 


Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly Asp Gly Cys Xaa Asp Lys 
225                 230                 235                 240 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys 
465 


<210>  113
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Polypeptide with internal non-peptidyl moiety. 
       TNR1B-alkyne-azide-PEG4-Fc6


<220>
<221>  SITE
<222>  (238)..(238)
<223>  Xaa = non-peptidyl moiety containing PEG4 linker

<400>  113

Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr Ala Pro Glu Pro Gly Ser 
1               5                   10                  15      


Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln Thr Ala Gln Met Cys Cys 
            20                  25                  30          


Ser Lys Cys Ser Pro Gly Gln His Ala Lys Val Phe Cys Thr Lys Thr 
        35                  40                  45              


Ser Asp Thr Val Cys Asp Ser Cys Glu Asp Ser Thr Tyr Thr Gln Leu 
    50                  55                  60                  


Trp Asn Trp Val Pro Glu Cys Leu Ser Cys Gly Ser Arg Cys Ser Ser 
65                  70                  75                  80  


Asp Gln Val Glu Thr Gln Ala Cys Thr Arg Glu Gln Asn Arg Ile Cys 
                85                  90                  95      


Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu Ser Lys Gln Glu Gly Cys 
            100                 105                 110         


Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg Pro Gly Phe Gly Val Ala 
        115                 120                 125             


Arg Pro Gly Thr Glu Thr Ser Asp Val Val Cys Lys Pro Cys Ala Pro 
    130                 135                 140                 


Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr Asp Ile Cys Arg Pro His 
145                 150                 155                 160 


Gln Ile Cys Asn Val Val Ala Ile Pro Gly Asn Ala Ser Met Asp Ala 
                165                 170                 175     


Val Cys Thr Ser Thr Ser Pro Thr Arg Ser Met Ala Pro Gly Ala Val 
            180                 185                 190         


His Leu Pro Gln Pro Val Ser Thr Arg Ser Gln His Thr Gln Pro Thr 
        195                 200                 205             


Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser Phe Leu Leu Pro Met Gly 
    210                 215                 220                 


Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly Asp Gly Cys Xaa Asp Lys 
225                 230                 235                 240 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        275                 280                 285             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    290                 295                 300                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                325                 330                 335     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            340                 345                 350         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        355                 360                 365             


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
    370                 375                 380                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
385                 390                 395                 400 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                405                 410                 415     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            420                 425                 430         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        435                 440                 445             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460                 


Lys 
465 


<210>  114
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Etanercept

<400>  114

Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr Ala Pro Glu Pro Gly Ser 
1               5                   10                  15      


Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln Thr Ala Gln Met Cys Cys 
            20                  25                  30          


Ser Lys Cys Ser Pro Gly Gln His Ala Lys Val Phe Cys Thr Lys Thr 
        35                  40                  45              


Ser Asp Thr Val Cys Asp Ser Cys Glu Asp Ser Thr Tyr Thr Gln Leu 
    50                  55                  60                  


Trp Asn Trp Val Pro Glu Cys Leu Ser Cys Gly Ser Arg Cys Ser Ser 
65                  70                  75                  80  


Asp Gln Val Glu Thr Gln Ala Cys Thr Arg Glu Gln Asn Arg Ile Cys 
                85                  90                  95      


Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu Ser Lys Gln Glu Gly Cys 
            100                 105                 110         


Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg Pro Gly Phe Gly Val Ala 
        115                 120                 125             


Arg Pro Gly Thr Glu Thr Ser Asp Val Val Cys Lys Pro Cys Ala Pro 
    130                 135                 140                 


Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr Asp Ile Cys Arg Pro His 
145                 150                 155                 160 


Gln Ile Cys Asn Val Val Ala Ile Pro Gly Asn Ala Ser Met Asp Ala 
                165                 170                 175     


Val Cys Thr Ser Thr Ser Pro Thr Arg Ser Met Ala Pro Gly Ala Val 
            180                 185                 190         


His Leu Pro Gln Pro Val Ser Thr Arg Ser Gln His Thr Gln Pro Thr 
        195                 200                 205             


Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser Phe Leu Leu Pro Met Gly 
    210                 215                 220                 


Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly Asp Glu Pro Lys Ser Cys 
225                 230                 235                 240 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        275                 280                 285             


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Pro Gly Lys 
465         


<210>  115
<211>  4175
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pFUSE2ss-DE27-V -CLIg-hk

<400>  115
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaacatgta caggatgcaa ctcctgtctt gcattgcact aagtcttgca      600

cttgtcacga attcagacat ccagatgacc cagtctccat cctccctgtc tgcatctgta      660

ggggacagag tcaccatcac ttgtcgggca agtcagggca tcagaaatta cttagcctgg      720

tatcagcaaa aaccagggaa agcccctaag ctcctgatct atgctgcatc cactttgcaa      780

tcaggggtcc catctcggtt cagtggcagt ggatctggga cagatttcac tctcaccatc      840

agcagcctac agcctgaaga tgttgcaact tattactgtc aaaggtataa ccgtgcaccg      900

tatacttttg gccaggggac caaggtggaa atcaaacgta cggtggctgc accatctgtc      960

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg     1020

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa     1080

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc     1140

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa     1200

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgttag     1260

agggagctag ctcgacatga taagatacat tgatgagttt ggacaaacca caactagaat     1320

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtgaaatt     1380

tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt taacaacaac     1440

aattgcattc attttatgtt tcaggttcag ggggaggtgt gggaggtttt ttaaagcaag     1500

taaaacctct acaaatgtgg tatggaatta attctaaaat acagcatagc aaaactttaa     1560

cctccaaatc aagcctctac ttgaatcctt ttctgaggga tgaataaggc ataggcatca     1620

ggggctgttg ccaatgtgca ttagctgttt gcagcctcac cttctttcat ggagtttaag     1680

atatagtgta ttttcccaag gtttgaacta gctcttcatt tctttatgtt ttaaatgcac     1740

tgacctccca cattcccttt ttagtaaaat attcagaaat aatttaaata catcattgca     1800

atgaaaataa atgtttttta ttaggcagaa tccagatgct caaggccctt cataatatcc     1860

cccagtttag tagttggact tagggaacaa aggaaccttt aatagaaatt ggacagcaag     1920

aaagcgagct tctagcttta gttcctggtg tacttgaggg ggatgagttc ctcaatggtg     1980

gttttgacca gcttgccatt catctcaatg agcacaaagc agtcaggagc atagtcagag     2040

atgagctctc tgcacatgcc acaggggctg accaccctga tggatctgtc cacctcatca     2100

gagtaggggt gcctgacagc cacaatggtg tcaaagtcct tctgcccgtt gctcacagca     2160

gacccaatgg caatggcttc agcacagaca gtgaccctgc caatgtaggc ctcaatgtgg     2220

acagcagaga tgatctcccc agtcttggtc ctgatggccg ccccgacatg gtgcttgttg     2280

tcctcataga gcatggtgat cttctcagtg gcgacctcca ccagctccag atcctgctga     2340

gagatgttga aggtcttcat gatggctcct cctgtcagga gaggaaagag aagaaggtta     2400

gtacaattgc tatagtgagt tgtattatac tatgcttatg attaattgtc aaactagggc     2460

tgcagggttc atagtgccac ttttcctgca ctgccccatc tcctgcccac cctttcccag     2520

gcatagacag tcagtgactt accaaactca caggagggag aaggcagaag cttgagacag     2580

acccgcggga ccgccgaact gcgaggggac gtggctaggg cggcttcttt tatggtgcgc     2640

cggccctcgg aggcagggcg ctcggggagg cctagcggcc aatctgcggt ggcaggaggc     2700

ggggccgaag gccgtgcctg accaatccgg agcacatagg agtctcagcc ccccgcccca     2760

aagcaagggg aagtcacgcg cctgtagcgc cagcgtgttg tgaaatgggg gcttgggggg     2820

gttggggccc tgactagtca aaacaaactc ccattgacgt caatggggtg gagacttgga     2880

aatccccgtg agtcaaaccg ctatccacgc ccattgatgt actgccaaaa ccgcatcatc     2940

atggtaatag cgatgactaa tacgtagatg tactgccaag taggaaagtc ccataaggtc     3000

atgtactggg cataatgcca ggcgggccat ttaccgtcat tgacgtcaat agggggcgta     3060

cttggcatat gatacacttg atgtactgcc aagtgggcag tttaccgtaa atactccacc     3120

cattgacgtc aatggaaagt ccctattggc gttactatgg gaacatacgt cattattgac     3180

gtcaatgggc gggggtcgtt gggcggtcag ccaggcgggc catttaccgt aagttatgta     3240

acgcctgcag gttaattaag aacatgtgag caaaaggcca gcaaaaggcc aggaaccgta     3300

aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa     3360

atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc     3420

cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt     3480

ccgcctttct cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca     3540

gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg     3600

accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat     3660

cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta     3720

cagagttctt gaagtggtgg cctaactacg gctacactag aagaacagta tttggtatct     3780

gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac     3840

aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa     3900

aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa     3960

actcacgtta agggattttg gtcatggcta gttaattaac atttaaatca gcggccgcaa     4020

taaaatatct ttattttcat tacatctgtg tgttggtttt ttgtgtgaat cgtaactaac     4080

atacgctctc catcaaaaca aaacgaaaca aaacaaacta gcaaaatagg ctgtccccag     4140

tgcaagtgca ggtgccagaa catttctcta tcgaa                                4175


<210>  116
<211>  4776
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pPUSEss-DE27-V 1-CHIg-hG1-Mth-1

<400>  116
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca      600

ttgcactaag tcttgcactt gtcacgaatt cggaggtgca gctggtggag tctgggggag      660

gcttggtaca gcccggcagg tccctgagac tctcctgtgc ggcctctgga ttcacctttg      720

atgattatgc catgcactgg gtccggcaag ctccagggaa gggcctggaa tgggtctcag      780

ctatcacttg gaatagtggt cacatagact atgcggactc tgtggagggc cgattcacca      840

tctccagaga caacgccaag aactccctgt atctgcaaat gaacagtctg agagctgagg      900

atacggccgt atattactgt gcgaaagtct cgtaccttag caccgcgtcc tcccttgact      960

attggggcca aggtaccctg gtcaccgtct cgagtgctag caccaagggc ccatcggtct     1020

tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg ggctgcctgg     1080

tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg     1140

gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc agcagcgtgg     1200

tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg aatcacaagc     1260

ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa actcacacat     1320

gcgtatccgg tgacaccatt gtaatgacta gtggcgggcc ccgcactgtg gctgaactgg     1380

agggcaaacc gttcaccgca ctgattcgcg gctctggcta cccatgcccc tcaggtttct     1440

tccgcacctg tgaacgtgac gtatatgatc tgcgtacacg tgagggtcat tgcttacgtt     1500

tgacccatga tcaccgtgtt ctggtgatgg atggtggcct ggaatggcgt gccgcgggtg     1560

aactggaacg cggcgaccgc ctggtgatgg atgatgcagc tggcgagttt ccggcactgg     1620

caaccttccg tggcctgcgt ggcgctggcc gccaggatgt ttatgacgct actgtttacg     1680

gtgctagcgc attcactgct aatggcttca ttgtacacgc atgtggcgag cagcccggga     1740

ccggtctgaa ctcaggcctc acgacaaatc ctggtgtatc cgcttggcag gtcaacacag     1800

cttatactgc gggacaattg gtcacatata acggcaagac gtataaatgt ttgcagcccc     1860

acacctcctt ggcaggatgg gaaccatcca acgttcctgc cttgtggcag cttcaatgag     1920

tcctagctgg ccagacatga taagatacat tgatgagttt ggacaaacca caactagaat     1980

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat     2040

tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca     2100

gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtatggaatt     2160

aattctaaaa tacagcatag caaaacttta acctccaaat caagcctcta cttgaatcct     2220

tttctgaggg atgaataagg cataggcatc aggggctgtt gccaatgtgc attagctgtt     2280

tgcagcctca ccttctttca tggagtttaa gatatagtgt attttcccaa ggtttgaact     2340

agctcttcat ttctttatgt tttaaatgca ctgacctccc acattccctt tttagtaaaa     2400

tattcagaaa taatttaaat acatcattgc aatgaaaata aatgtttttt attaggcaga     2460

atccagatgc tcaaggccct tcataatatc ccccagttta gtagttggac ttagggaaca     2520

aaggaacctt taatagaaat tggacagcaa gaaagcgagc ttctagctta tcctcagtcc     2580

tgctcctctg ccacaaagtg cacgcagttg ccggccgggt cgcgcagggc gaactcccgc     2640

ccccacggct gctcgccgat ctcggtcatg gccggcccgg aggcgtcccg gaagttcgtg     2700

gacacgacct ccgaccactc ggcgtacagc tcgtccaggc cgcgcaccca cacccaggcc     2760

agggtgttgt ccggcaccac ctggtcctgg accgcgctga tgaacagggt cacgtcgtcc     2820

cggaccacac cggcgaagtc gtcctccacg aagtcccggg agaacccgag ccggtcggtc     2880

cagaactcga ccgctccggc gacgtcgcgc gcggtgagca ccggaacggc actggtcaac     2940

ttggccatga tggctcctcc tgtcaggaga ggaaagagaa gaaggttagt acaattgcta     3000

tagtgagttg tattatacta tgcagatata ctatgccaat gattaattgt caaactaggg     3060

ctgcagggtt catagtgcca cttttcctgc actgccccat ctcctgccca ccctttccca     3120

ggcatagaca gtcagtgact taccaaactc acaggaggga gaaggcagaa gcttgagaca     3180

gacccgcggg accgccgaac tgcgagggga cgtggctagg gcggcttctt ttatggtgcg     3240

ccggccctcg gaggcagggc gctcggggag gcctagcggc caatctgcgg tggcaggagg     3300

cggggccgaa ggccgtgcct gaccaatccg gagcacatag gagtctcagc cccccgcccc     3360

aaagcaaggg gaagtcacgc gcctgtagcg ccagcgtgtt gtgaaatggg ggcttggggg     3420

ggttggggcc ctgactagtc aaaacaaact cccattgacg tcaatggggt ggagacttgg     3480

aaatccccgt gagtcaaacc gctatccacg cccattgatg tactgccaaa accgcatcat     3540

catggtaata gcgatgacta atacgtagat gtactgccaa gtaggaaagt cccataaggt     3600

catgtactgg gcataatgcc aggcgggcca tttaccgtca ttgacgtcaa tagggggcgt     3660

acttggcata tgatacactt gatgtactgc caagtgggca gtttaccgta aatactccac     3720

ccattgacgt caatggaaag tccctattgg cgttactatg ggaacatacg tcattattga     3780

cgtcaatggg cgggggtcgt tgggcggtca gccaggcggg ccatttaccg taagttatgt     3840

aacgcctgca ggttaattaa gaacatgtga gcaaaaggcc agcaaaaggc caggaaccgt     3900

aaaaaggccg cgttgctggc gtttttccat aggctccgcc cccctgacga gcatcacaaa     3960

aatcgacgct caagtcagag gtggcgaaac ccgacaggac tataaagata ccaggcgttt     4020

ccccctggaa gctccctcgt gcgctctcct gttccgaccc tgccgcttac cggatacctg     4080

tccgcctttc tcccttcggg aagcgtggcg ctttctcata gctcacgctg taggtatctc     4140

agttcggtgt aggtcgttcg ctccaagctg ggctgtgtgc acgaaccccc cgttcagccc     4200

gaccgctgcg ccttatccgg taactatcgt cttgagtcca acccggtaag acacgactta     4260

tcgccactgg cagcagccac tggtaacagg attagcagag cgaggtatgt aggcggtgct     4320

acagagttct tgaagtggtg gcctaactac ggctacacta gaagaacagt atttggtatc     4380

tgcgctctgc tgaagccagt taccttcgga aaaagagttg gtagctcttg atccggcaaa     4440

caaaccaccg ctggtagcgg tggttttttt gtttgcaagc agcagattac gcgcagaaaa     4500

aaaggatctc aagaagatcc tttgatcttt tctacggggt ctgacgctca gtggaacgaa     4560

aactcacgtt aagggatttt ggtcatggct agttaattaa catttaaatc agcggccgca     4620

ataaaatatc tttattttca ttacatctgt gtgttggttt tttgtgtgaa tcgtaactaa     4680

catacgctct ccatcaaaac aaaacgaaac aaaacaaact agcaaaatag gctgtcccca     4740

gtgcaagtgc aggtgccaga acatttctct atcgaa                               4776


<210>  117
<211>  4779
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pFUSEss-DE27-V 1-CHIg-hG1-Mth-2

<400>  117
ggatctgcga tcgctccggt gcccgtcagt gggcagagcg cacatcgccc acagtccccg       60

agaagttggg gggaggggtc ggcaattgaa cgggtgccta gagaaggtgg cgcggggtaa      120

actgggaaag tgatgtcgtg tactggctcc gcctttttcc cgagggtggg ggagaaccgt      180

atataagtgc agtagtcgcc gtgaacgttc tttttcgcaa cgggtttgcc gccagaacac      240

agctgaagct tcgaggggct cgcatctctc cttcacgcgc ccgccgccct acctgaggcc      300

gccatccacg ccggttgagt cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg      360

cgtccgccgt ctaggtaagt ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc      420

cttggagcct acctagactc agccggctct ccacgctttg cctgaccctg cttgctcaac      480

tctacgtctt tgtttcgttt tctgttctgc gccgttacag atccaagctg tgaccggcgc      540

ctacctgaga tcaccggcga aggagggcca ccatgtacag gatgcaactc ctgtcttgca      600

ttgcactaag tcttgcactt gtcacgaatt cggaggtgca gctggtggag tctgggggag      660

gcttggtaca gcccggcagg tccctgagac tctcctgtgc ggcctctgga ttcacctttg      720

atgattatgc catgcactgg gtccggcaag ctccagggaa gggcctggaa tgggtctcag      780

ctatcacttg gaatagtggt cacatagact atgcggactc tgtggagggc cgattcacca      840

tctccagaga caacgccaag aactccctgt atctgcaaat gaacagtctg agagctgagg      900

atacggccgt atattactgt gcgaaagtct cgtaccttag caccgcgtcc tcccttgact      960

attggggcca aggtaccctg gtcaccgtct cgagtgctag caccaagggc ccatcggtct     1020

tccccctggc accctcctcc aagagcacct ctgggggcac agcggccctg ggctgcctgg     1080

tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg     1140

gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc agcagcgtgg     1200

tgaccgtgcc ctccagcagc ttgggcaccc agacctacat ctgcaacgtg aatcacaagc     1260

ccagcaacac caaggtggac aagaaagttg agcccaaatc ttgtgacaaa actcacacag     1320

ggtgcgtatc cggtgacacc attgtaatga ctagtggcgg gccccgcact gtggctgaac     1380

tggagggcaa accgttcacc gcactgattc gcggctctgg ctacccatgc ccctcaggtt     1440

tcttccgcac ctgtgaacgt gacgtatatg atctgcgtac acgtgagggt cattgcttac     1500

gtttgaccca tgatcaccgt gttctggtga tggatggtgg cctggaatgg cgtgccgcgg     1560

gtgaactgga acgcggcgac cgcctggtga tggatgatgc agctggcgag tttccggcac     1620

tggcaacctt ccgtggcctg cgtggcgctg gccgccagga tgtttatgac gctactgttt     1680

acggtgctag cgcattcact gctaatggct tcattgtaca cgcatgtggc gagcagcccg     1740

ggaccggtct gaactcaggc ctcacgacaa atcctggtgt atccgcttgg caggtcaaca     1800

cagcttatac tgcgggacaa ttggtcacat ataacggcaa gacgtataaa tgtttgcagc     1860

cccacacctc cttggcagga tgggaaccat ccaacgttcc tgccttgtgg cagcttcaat     1920

gagtcctagc tggccagaca tgataagata cattgatgag tttggacaaa ccacaactag     1980

aatgcagtga aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac     2040

cattataagc tgcaataaac aagttaacaa caacaattgc attcatttta tgtttcaggt     2100

tcagggggag gtgtgggagg ttttttaaag caagtaaaac ctctacaaat gtggtatgga     2160

attaattcta aaatacagca tagcaaaact ttaacctcca aatcaagcct ctacttgaat     2220

ccttttctga gggatgaata aggcataggc atcaggggct gttgccaatg tgcattagct     2280

gtttgcagcc tcaccttctt tcatggagtt taagatatag tgtattttcc caaggtttga     2340

actagctctt catttcttta tgttttaaat gcactgacct cccacattcc ctttttagta     2400

aaatattcag aaataattta aatacatcat tgcaatgaaa ataaatgttt tttattaggc     2460

agaatccaga tgctcaaggc ccttcataat atcccccagt ttagtagttg gacttaggga     2520

acaaaggaac ctttaataga aattggacag caagaaagcg agcttctagc ttatcctcag     2580

tcctgctcct ctgccacaaa gtgcacgcag ttgccggccg ggtcgcgcag ggcgaactcc     2640

cgcccccacg gctgctcgcc gatctcggtc atggccggcc cggaggcgtc ccggaagttc     2700

gtggacacga cctccgacca ctcggcgtac agctcgtcca ggccgcgcac ccacacccag     2760

gccagggtgt tgtccggcac cacctggtcc tggaccgcgc tgatgaacag ggtcacgtcg     2820

tcccggacca caccggcgaa gtcgtcctcc acgaagtccc gggagaaccc gagccggtcg     2880

gtccagaact cgaccgctcc ggcgacgtcg cgcgcggtga gcaccggaac ggcactggtc     2940

aacttggcca tgatggctcc tcctgtcagg agaggaaaga gaagaaggtt agtacaattg     3000

ctatagtgag ttgtattata ctatgcagat atactatgcc aatgattaat tgtcaaacta     3060

gggctgcagg gttcatagtg ccacttttcc tgcactgccc catctcctgc ccaccctttc     3120

ccaggcatag acagtcagtg acttaccaaa ctcacaggag ggagaaggca gaagcttgag     3180

acagacccgc gggaccgccg aactgcgagg ggacgtggct agggcggctt cttttatggt     3240

gcgccggccc tcggaggcag ggcgctcggg gaggcctagc ggccaatctg cggtggcagg     3300

aggcggggcc gaaggccgtg cctgaccaat ccggagcaca taggagtctc agccccccgc     3360

cccaaagcaa ggggaagtca cgcgcctgta gcgccagcgt gttgtgaaat gggggcttgg     3420

gggggttggg gccctgacta gtcaaaacaa actcccattg acgtcaatgg ggtggagact     3480

tggaaatccc cgtgagtcaa accgctatcc acgcccattg atgtactgcc aaaaccgcat     3540

catcatggta atagcgatga ctaatacgta gatgtactgc caagtaggaa agtcccataa     3600

ggtcatgtac tgggcataat gccaggcggg ccatttaccg tcattgacgt caataggggg     3660

cgtacttggc atatgataca cttgatgtac tgccaagtgg gcagtttacc gtaaatactc     3720

cacccattga cgtcaatgga aagtccctat tggcgttact atgggaacat acgtcattat     3780

tgacgtcaat gggcgggggt cgttgggcgg tcagccaggc gggccattta ccgtaagtta     3840

tgtaacgcct gcaggttaat taagaacatg tgagcaaaag gccagcaaaa ggccaggaac     3900

cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc gcccccctga cgagcatcac     3960

aaaaatcgac gctcaagtca gaggtggcga aacccgacag gactataaag ataccaggcg     4020

tttccccctg gaagctccct cgtgcgctct cctgttccga ccctgccgct taccggatac     4080

ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc atagctcacg ctgtaggtat     4140

ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg tgcacgaacc ccccgttcag     4200

cccgaccgct gcgccttatc cggtaactat cgtcttgagt ccaacccggt aagacacgac     4260

ttatcgccac tggcagcagc cactggtaac aggattagca gagcgaggta tgtaggcggt     4320

gctacagagt tcttgaagtg gtggcctaac tacggctaca ctagaagaac agtatttggt     4380

atctgcgctc tgctgaagcc agttaccttc ggaaaaagag ttggtagctc ttgatccggc     4440

aaacaaacca ccgctggtag cggtggtttt tttgtttgca agcagcagat tacgcgcaga     4500

aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg ggtctgacgc tcagtggaac     4560

gaaaactcac gttaagggat tttggtcatg gctagttaat taacatttaa atcagcggcc     4620

gcaataaaat atctttattt tcattacatc tgtgtgttgg ttttttgtgt gaatcgtaac     4680

taacatacgc tctccatcaa aacaaaacga aacaaaacaa actagcaaaa taggctgtcc     4740

ccagtgcaag tgcaggtgcc agaacatttc tctatcgaa                            4779


<210>  118
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-kappa light chain of adalimumab

<400>  118

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly 
        35                  40                  45              


Ile Arg Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn 
            100                 105                 110         


Arg Ala Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  119
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mature kappa light chain of adalimumab

<400>  119

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  120
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain-intein chimeric polypeptide

<400>  120

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Val Ser Gly Asp Thr Ile 
                245                 250                 255     


Val Met Thr Ser Gly Gly Pro Arg Thr Val Ala Glu Leu Glu Gly Lys 
            260                 265                 270         


Pro Phe Thr Ala Leu Ile Arg Gly Ser Gly Tyr Pro Cys Pro Ser Gly 
        275                 280                 285             


Phe Phe Arg Thr Cys Glu Arg Asp Val Tyr Asp Leu Arg Thr Arg Glu 
    290                 295                 300                 


Gly His Cys Leu Arg Leu Thr His Asp His Arg Val Leu Val Met Asp 
305                 310                 315                 320 


Gly Gly Leu Glu Trp Arg Ala Ala Gly Glu Leu Glu Arg Gly Asp Arg 
                325                 330                 335     


Leu Val Met Asp Asp Ala Ala Gly Glu Phe Pro Ala Leu Ala Thr Phe 
            340                 345                 350         


Arg Gly Leu Arg Gly Ala Gly Arg Gln Asp Val Tyr Asp Ala Thr Val 
        355                 360                 365             


Tyr Gly Ala Ser Ala Phe Thr Ala Asn Gly Phe Ile Val His Ala Cys 
    370                 375                 380                 


Gly Glu Gln Pro Gly Thr Gly Leu Asn Ser Gly Leu Thr Thr Asn Pro 
385                 390                 395                 400 


Gly Val Ser Ala Trp Gln Val Asn Thr Ala Tyr Thr Ala Gly Gln Leu 
                405                 410                 415     


Val Thr Tyr Asn Gly Lys Thr Tyr Lys Cys Leu Gln Pro His Thr Ser 
            420                 425                 430         


Leu Ala Gly Trp Glu Pro Ser Asn Val Pro Ala Leu Trp Gln Leu Gln 
        435                 440                 445             


<210>  121
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mature heavy chain-intein fusion protein

<400>  121

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Val Ser Gly Asp Thr Ile Val Met Thr Ser 
225                 230                 235                 240 


Gly Gly Pro Arg Thr Val Ala Glu Leu Glu Gly Lys Pro Phe Thr Ala 
                245                 250                 255     


Leu Ile Arg Gly Ser Gly Tyr Pro Cys Pro Ser Gly Phe Phe Arg Thr 
            260                 265                 270         


Cys Glu Arg Asp Val Tyr Asp Leu Arg Thr Arg Glu Gly His Cys Leu 
        275                 280                 285             


Arg Leu Thr His Asp His Arg Val Leu Val Met Asp Gly Gly Leu Glu 
    290                 295                 300                 


Trp Arg Ala Ala Gly Glu Leu Glu Arg Gly Asp Arg Leu Val Met Asp 
305                 310                 315                 320 


Asp Ala Ala Gly Glu Phe Pro Ala Leu Ala Thr Phe Arg Gly Leu Arg 
                325                 330                 335     


Gly Ala Gly Arg Gln Asp Val Tyr Asp Ala Thr Val Tyr Gly Ala Ser 
            340                 345                 350         


Ala Phe Thr Ala Asn Gly Phe Ile Val His Ala Cys Gly Glu Gln Pro 
        355                 360                 365             


Gly Thr Gly Leu Asn Ser Gly Leu Thr Thr Asn Pro Gly Val Ser Ala 
    370                 375                 380                 


Trp Gln Val Asn Thr Ala Tyr Thr Ala Gly Gln Leu Val Thr Tyr Asn 
385                 390                 395                 400 


Gly Lys Thr Tyr Lys Cys Leu Gln Pro His Thr Ser Leu Ala Gly Trp 
                405                 410                 415     


Glu Pro Ser Asn Val Pro Ala Leu Trp Gln Leu Gln 
            420                 425             


<210>  122
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain-intein chimeric polypeptide

<400>  122

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
        35                  40                  45              


Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                85                  90                  95      


Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Gly Cys Val Ser Gly Asp Thr 
                245                 250                 255     


Ile Val Met Thr Ser Gly Gly Pro Arg Thr Val Ala Glu Leu Glu Gly 
            260                 265                 270         


Lys Pro Phe Thr Ala Leu Ile Arg Gly Ser Gly Tyr Pro Cys Pro Ser 
        275                 280                 285             


Gly Phe Phe Arg Thr Cys Glu Arg Asp Val Tyr Asp Leu Arg Thr Arg 
    290                 295                 300                 


Glu Gly His Cys Leu Arg Leu Thr His Asp His Arg Val Leu Val Met 
305                 310                 315                 320 


Asp Gly Gly Leu Glu Trp Arg Ala Ala Gly Glu Leu Glu Arg Gly Asp 
                325                 330                 335     


Arg Leu Val Met Asp Asp Ala Ala Gly Glu Phe Pro Ala Leu Ala Thr 
            340                 345                 350         


Phe Arg Gly Leu Arg Gly Ala Gly Arg Gln Asp Val Tyr Asp Ala Thr 
        355                 360                 365             


Val Tyr Gly Ala Ser Ala Phe Thr Ala Asn Gly Phe Ile Val His Ala 
    370                 375                 380                 


Cys Gly Glu Gln Pro Gly Thr Gly Leu Asn Ser Gly Leu Thr Thr Asn 
385                 390                 395                 400 


Pro Gly Val Ser Ala Trp Gln Val Asn Thr Ala Tyr Thr Ala Gly Gln 
                405                 410                 415     


Leu Val Thr Tyr Asn Gly Lys Thr Tyr Lys Cys Leu Gln Pro His Thr 
            420                 425                 430         


Ser Leu Ala Gly Trp Glu Pro Ser Asn Val Pro Ala Leu Trp Gln Leu 
        435                 440                 445             


Gln 
    


<210>  123
<211>  429
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mature heavy chain-intein fusion protein

<400>  123

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Gly Cys Val Ser Gly Asp Thr Ile Val Met Thr 
225                 230                 235                 240 


Ser Gly Gly Pro Arg Thr Val Ala Glu Leu Glu Gly Lys Pro Phe Thr 
                245                 250                 255     


Ala Leu Ile Arg Gly Ser Gly Tyr Pro Cys Pro Ser Gly Phe Phe Arg 
            260                 265                 270         


Thr Cys Glu Arg Asp Val Tyr Asp Leu Arg Thr Arg Glu Gly His Cys 
        275                 280                 285             


Leu Arg Leu Thr His Asp His Arg Val Leu Val Met Asp Gly Gly Leu 
    290                 295                 300                 


Glu Trp Arg Ala Ala Gly Glu Leu Glu Arg Gly Asp Arg Leu Val Met 
305                 310                 315                 320 


Asp Asp Ala Ala Gly Glu Phe Pro Ala Leu Ala Thr Phe Arg Gly Leu 
                325                 330                 335     


Arg Gly Ala Gly Arg Gln Asp Val Tyr Asp Ala Thr Val Tyr Gly Ala 
            340                 345                 350         


Ser Ala Phe Thr Ala Asn Gly Phe Ile Val His Ala Cys Gly Glu Gln 
        355                 360                 365             


Pro Gly Thr Gly Leu Asn Ser Gly Leu Thr Thr Asn Pro Gly Val Ser 
    370                 375                 380                 


Ala Trp Gln Val Asn Thr Ala Tyr Thr Ala Gly Gln Leu Val Thr Tyr 
385                 390                 395                 400 


Asn Gly Lys Thr Tyr Lys Cys Leu Gln Pro His Thr Ser Leu Ala Gly 
                405                 410                 415     


Trp Glu Pro Ser Asn Val Pro Ala Leu Trp Gln Leu Gln 
            420                 425                 


<210>  124
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of alkyne-modified adalimumab Fab-1 protein. Modified at 
       C-Terminus.


<220>
<221>  SITE
<222>  (230)..(230)
<223>  Xaa = cysteine-alkyne

<400>  124

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Xaa 
225                 230 


<210>  125
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of alkyne-modified adalimumab Fab-2 protein. Motified at 
       C-Terminus


<220>
<221>  SITE
<222>  (131)..(131)
<223>  Xaa = cysteine-alkyne

<220>
<221>  misc_feature
<222>  (231)..(231)
<223>  Xaa can be any naturally occurring amino acid

<400>  125

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Gly Xaa 
225                 230     


<210>  126
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of azide-modified adalimumab Fab-1 protein. Modified 
       C-Terminus


<220>
<221>  SITE
<222>  (230)..(230)
<223>  Xaa = cysteine-azide

<400>  126

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Xaa 
225                 230 


<210>  127
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Part of azide-modified adalimumab Fab-2 protein. Modified 
       C-Terminus


<220>
<221>  SITE
<222>  (231)..(231)
<223>  Xaa = cysteine-azide

<400>  127

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Gly Xaa 
225                 230     


<210>  128
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  128

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  129
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  129

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  130
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab light chain having the N-terminal sequence C

<400>  130

Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val 
1               5                   10                  15      


Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr 
            20                  25                  30          


Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser 
    50                  55                  60                  


Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro 
                85                  90                  95      


Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  131
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having SHH signal peptide

<400>  131

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Asp Ile Gln Met Thr Gln Ser Pro 
            20                  25                  30          


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
        35                  40                  45              


Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  132
<211>  238
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having IFN signal peptide

<400>  132

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Ile Gln Met Thr Gln Ser Pro 
            20                  25                  30          


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
        35                  40                  45              


Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser 
65                  70                  75                  80  


Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  133
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having CETP signal peptide

<400>  133

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
            20                  25                  30          


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn 
        35                  40                  45              


Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
    50                  55                  60                  


Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe 
65                  70                  75                  80  


Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
                85                  90                  95      


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr 
            100                 105                 110         


Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
        115                 120                 125             


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
    130                 135                 140                 


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
145                 150                 155                 160 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
                165                 170                 175     


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
            180                 185                 190         


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
        195                 200                 205             


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
    210                 215                 220                 


Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230         


<210>  134
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab light chain having the N-terminal sequence CP

<400>  134

Cys Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser 
1               5                   10                  15      


Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn 
            20                  25                  30          


Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe 
    50                  55                  60                  


Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
65                  70                  75                  80  


Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr 
                85                  90                  95      


Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  135
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having SHH signal peptide

<400>  135

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Asp Ile Gln Met Thr Gln Ser 
            20                  25                  30          


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr 
65                  70                  75                  80  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  136
<211>  239
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having IFN signal peptide

<400>  136

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Asp Ile Gln Met Thr Gln Ser 
            20                  25                  30          


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr 
65                  70                  75                  80  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe 
                85                  90                  95      


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
            100                 105                 110         


Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys 
        115                 120                 125             


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  137
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having CETP signal peptide

<400>  137

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
            20                  25                  30          


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
        35                  40                  45              


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
    50                  55                  60                  


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
            100                 105                 110         


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
    130                 135                 140                 


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
145                 150                 155                 160 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
                165                 170                 175     


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
            180                 185                 190         


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
        195                 200                 205             


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
    210                 215                 220                 


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230             


<210>  138
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab light chain having the N-terminal sequence CPP

<400>  138

Cys Pro Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
            20                  25                  30          


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
                85                  90                  95      


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  139
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having SHH signal peptide

<400>  139

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Pro Asp Ile Gln Met Thr Gln 
            20                  25                  30          


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        35                  40                  45              


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
65                  70                  75                  80  


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  140
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having IFN signal peptide

<400>  140

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Pro Asp Ile Gln Met Thr Gln 
            20                  25                  30          


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        35                  40                  45              


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
65                  70                  75                  80  


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  141
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having CETP signal peptide

<400>  141

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  142
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab light chain having the N-terminal sequence CPR

<400>  142

Cys Pro Arg Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
            20                  25                  30          


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
                85                  90                  95      


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  143
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having SHH signal peptide

<400>  143

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Arg Asp Ile Gln Met Thr Gln 
            20                  25                  30          


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        35                  40                  45              


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
65                  70                  75                  80  


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  144
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having IFN signal peptide

<400>  144

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Arg Asp Ile Gln Met Thr Gln 
            20                  25                  30          


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        35                  40                  45              


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
65                  70                  75                  80  


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  145
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having CETP signal peptide

<400>  145

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Arg Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  146
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab light chain having the N-terminal sequence CPS

<400>  146

Cys Pro Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
            20                  25                  30          


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
                85                  90                  95      


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  147
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having SHH signal peptide

<400>  147

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Ser Asp Ile Gln Met Thr Gln 
            20                  25                  30          


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        35                  40                  45              


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
65                  70                  75                  80  


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  148
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having IFN signal peptide

<400>  148

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Ser Asp Ile Gln Met Thr Gln 
            20                  25                  30          


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        35                  40                  45              


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
65                  70                  75                  80  


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  149
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having CETP signal peptide

<400>  149

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  150
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab light chain having the N-terminal sequence CDKT

<400>  150

Cys Asp Lys Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
1               5                   10                  15      


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
            20                  25                  30          


Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
                85                  90                  95      


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  151
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having SHH signal peptide

<400>  151

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Asp Lys Thr Asp Ile Gln Met Thr 
            20                  25                  30          


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        35                  40                  45              


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
65                  70                  75                  80  


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
    130                 135                 140                 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
145                 150                 155                 160 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
                165                 170                 175     


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
    210                 215                 220                 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
225                 230                 235                 240 


Cys 
    


<210>  152
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having IFN signal peptide

<400>  152

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Lys Thr Asp Ile Gln Met Thr 
            20                  25                  30          


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
        35                  40                  45              


Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln 
    50                  55                  60                  


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe 
65                  70                  75                  80  


Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
            100                 105                 110         


Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
    130                 135                 140                 


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
145                 150                 155                 160 


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
                165                 170                 175     


Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 
            180                 185                 190         


Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 
        195                 200                 205             


Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 
    210                 215                 220                 


His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 
225                 230                 235                 240 


Cys 
    


<210>  153
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having CETP signal peptide

<400>  153

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Asp Lys Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        35                  40                  45              


Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His 
            100                 105                 110         


Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        115                 120                 125             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    130                 135                 140                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
145                 150                 155                 160 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                165                 170                 175     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            180                 185                 190         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        195                 200                 205             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    210                 215                 220                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235 


<210>  154
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab light chain having the N-terminal sequence CDKTHT

<400>  154

Cys Asp Lys Thr His Thr Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
1               5                   10                  15      


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25                  30          


Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  155
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having SHH signal peptide

<400>  155

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Asp Lys Thr His Thr Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala 
65                  70                  75                  80  


Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser 
                85                  90                  95      


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly 
        115                 120                 125             


Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val 
    130                 135                 140                 


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
145                 150                 155                 160 


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
                165                 170                 175     


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
            180                 185                 190         


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
        195                 200                 205             


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
    210                 215                 220                 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
225                 230                 235                 240 


Gly Glu Cys 
            


<210>  156
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having IFN signal peptide

<400>  156

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Lys Thr His Thr Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala 
65                  70                  75                  80  


Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser 
                85                  90                  95      


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly 
        115                 120                 125             


Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val 
    130                 135                 140                 


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
145                 150                 155                 160 


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
                165                 170                 175     


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
            180                 185                 190         


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
        195                 200                 205             


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
    210                 215                 220                 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
225                 230                 235                 240 


Gly Glu Cys 
            


<210>  157
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having CETP signal peptide

<400>  157

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Asp Lys Thr His Thr Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  158
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab light chain having the N-terminal sequence CVE

<400>  158

Cys Val Glu Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala 
1               5                   10                  15      


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val 
            20                  25                  30          


Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg 
    50                  55                  60                  


Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
65                  70                  75                  80  


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr 
                85                  90                  95      


Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
            100                 105                 110         


Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 
        115                 120                 125             


Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 
    130                 135                 140                 


Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 
145                 150                 155                 160 


Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 
                165                 170                 175     


Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 
            180                 185                 190         


Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 
        195                 200                 205             


Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215         


<210>  159
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having SHH signal peptide

<400>  159

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Val Glu Asp Ile Gln Met Thr Gln 
            20                  25                  30          


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        35                  40                  45              


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
65                  70                  75                  80  


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  160
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having IFN signal peptide

<400>  160

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Val Glu Asp Ile Gln Met Thr Gln 
            20                  25                  30          


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
        35                  40                  45              


Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu 
65                  70                  75                  80  


Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210>  161
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having CETP signal peptide

<400>  161

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Val Glu Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr 
            100                 105                 110         


Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  162
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab light chain having the N-terminal sequence CDTPPP

<400>  162

Cys Asp Thr Pro Pro Pro Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
1               5                   10                  15      


Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25                  30          


Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys 
        35                  40                  45              


Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val 
    50                  55                  60                  


Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
        115                 120                 125             


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
    130                 135                 140                 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
145                 150                 155                 160 


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
                165                 170                 175     


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
            180                 185                 190         


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
        195                 200                 205             


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 220 


<210>  163
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having SHH signal peptide

<400>  163

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Asp Thr Pro Pro Pro Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala 
65                  70                  75                  80  


Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser 
                85                  90                  95      


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly 
        115                 120                 125             


Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val 
    130                 135                 140                 


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
145                 150                 155                 160 


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
                165                 170                 175     


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
            180                 185                 190         


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
        195                 200                 205             


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
    210                 215                 220                 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
225                 230                 235                 240 


Gly Glu Cys 
            


<210>  164
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having IFN signal peptide

<400>  164

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Thr Pro Pro Pro Asp Ile Gln 
            20                  25                  30          


Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val 
        35                  40                  45              


Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala Val Ala Trp 
    50                  55                  60                  


Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala 
65                  70                  75                  80  


Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser 
                85                  90                  95      


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro Thr Phe Gly 
        115                 120                 125             


Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val 
    130                 135                 140                 


Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser 
145                 150                 155                 160 


Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln 
                165                 170                 175     


Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val 
            180                 185                 190         


Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu 
        195                 200                 205             


Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu 
    210                 215                 220                 


Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg 
225                 230                 235                 240 


Gly Glu Cys 
            


<210>  165
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-light chimeric polypeptide having CETP signal peptide

<400>  165

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Asp Thr Pro Pro Pro Asp Ile Gln Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala 
        35                  40                  45              


Ser Gln Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ala Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            100                 105                 110         


Gln His Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu 
        115                 120                 125             


Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser 
    130                 135                 140                 


Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn 
145                 150                 155                 160 


Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala 
                165                 170                 175     


Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys 
            180                 185                 190         


Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp 
        195                 200                 205             


Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu 
    210                 215                 220                 


Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235         


<210>  166
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab heavy chain having the N-terminal sequence C

<400>  166

Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp 
            20                  25                  30          


Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  167
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having SHH signal peptide

<400>  167

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Glu Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
65                  70                  75                  80  


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
                85                  90                  95      


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
        115                 120                 125             


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  168
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having IFN signal peptide

<400>  168

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Glu Val Gln Leu Val Glu Ser Gly 
            20                  25                  30          


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        35                  40                  45              


Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala 
    50                  55                  60                  


Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly 
65                  70                  75                  80  


Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala 
                85                  90                  95      


Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala 
            100                 105                 110         


Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe 
        115                 120                 125             


Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    130                 135                 140                 


Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
145                 150                 155                 160 


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
                165                 170                 175     


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
            180                 185                 190         


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
        195                 200                 205             


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
    210                 215                 220                 


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
225                 230                 235                 240 


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
    370                 375                 380                 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 


<210>  169
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having CETP signal peptide

<400>  169

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys 
        35                  40                  45              


Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr 
                85                  90                  95      


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  170
<211>  452
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab heavy chain having the N-terminal sequence CP

<400>  170

Cys Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys 
            20                  25                  30          


Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  171
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having SHH signal peptide

<400>  171

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Glu Val Gln Leu Val Glu Ser 
            20                  25                  30          


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        35                  40                  45              


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln 
    50                  55                  60                  


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn 
65                  70                  75                  80  


Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                85                  90                  95      


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
            100                 105                 110         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly 
        115                 120                 125             


Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  172
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having IFN signal peptide

<400>  172

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Glu Val Gln Leu Val Glu Ser 
            20                  25                  30          


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        35                  40                  45              


Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln 
    50                  55                  60                  


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn 
65                  70                  75                  80  


Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                85                  90                  95      


Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg 
            100                 105                 110         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly 
        115                 120                 125             


Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135                 140                 


Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 
145                 150                 155                 160 


Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 
                165                 170                 175     


Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 
            180                 185                 190         


Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
        195                 200                 205             


Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 
    210                 215                 220                 


Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 
225                 230                 235                 240 


Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                245                 250                 255     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    290                 295                 300                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                325                 330                 335     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            340                 345                 350         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        355                 360                 365             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
    370                 375                 380                 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
385                 390                 395                 400 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                405                 410                 415     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            420                 425                 430         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        435                 440                 445             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    450                 455                 460                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475 


<210>  173
<211>  469
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having CETP signal peptide

<400>  173

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
                85                  90                  95      


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
    210                 215                 220                 


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
225                 230                 235                 240 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
                245                 250                 255     


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            260                 265                 270         


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        275                 280                 285             


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
    290                 295                 300                 


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
305                 310                 315                 320 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                325                 330                 335     


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
            340                 345                 350         


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        355                 360                 365             


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
    370                 375                 380                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
385                 390                 395                 400 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                405                 410                 415     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
            420                 425                 430         


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
        435                 440                 445             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    450                 455                 460                 


Leu Ser Pro Gly Lys 
465                 


<210>  174
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab heavy chain having the N-terminal sequence CPP

<400>  174

Cys Pro Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
            20                  25                  30          


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  175
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having SHH signal peptide

<400>  175

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Pro Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr 
65                  70                  75                  80  


Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp 
        115                 120                 125             


Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  176
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having IFN signal peptide

<400>  176

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Pro Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr 
65                  70                  75                  80  


Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp 
        115                 120                 125             


Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  177
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having CETP signal peptide

<400>  177

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
        35                  40                  45              


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  178
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab heavy chain having the N-terminal sequence CPR

<400>  178

Cys Pro Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
            20                  25                  30          


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  179
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having SHH signal peptide

<400>  179

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Arg Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr 
65                  70                  75                  80  


Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp 
        115                 120                 125             


Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  180
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having IFN signal peptide

<400>  180

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Arg Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr 
65                  70                  75                  80  


Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp 
        115                 120                 125             


Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  181
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having CETP signal peptide

<400>  181

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
        35                  40                  45              


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  182
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab heavy chain having the N-terminal sequence CPS

<400>  182

Cys Pro Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
            20                  25                  30          


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  183
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having SHH signal peptide

<400>  183

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Pro Ser Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr 
65                  70                  75                  80  


Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp 
        115                 120                 125             


Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  184
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having IFN signal peptide

<400>  184

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Pro Ser Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr 
65                  70                  75                  80  


Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp 
        115                 120                 125             


Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  185
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having CETP signal peptide

<400>  185

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Pro Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
        35                  40                  45              


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  186
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab heavy chain having the N-terminal sequence CDKT

<400>  186

Cys Asp Lys Thr Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
1               5                   10                  15      


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
            20                  25                  30          


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
    50                  55                  60                  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
65                  70                  75                  80  


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  187
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having SHH signal peptide

<400>  187

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Asp Lys Thr Glu Val Gln Leu Val 
            20                  25                  30          


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
        35                  40                  45              


Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val 
    50                  55                  60                  


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro 
65                  70                  75                  80  


Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                85                  90                  95      


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
            100                 105                 110         


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly 
        115                 120                 125             


Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475         


<210>  188
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having IFN signal peptide

<400>  188

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Lys Thr Glu Val Gln Leu Val 
            20                  25                  30          


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
        35                  40                  45              


Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val 
    50                  55                  60                  


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro 
65                  70                  75                  80  


Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                85                  90                  95      


Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser 
            100                 105                 110         


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly 
        115                 120                 125             


Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
    130                 135                 140                 


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
145                 150                 155                 160 


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
                165                 170                 175     


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
            180                 185                 190         


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
        195                 200                 205             


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
    210                 215                 220                 


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
225                 230                 235                 240 


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
                245                 250                 255     


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            260                 265                 270         


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        275                 280                 285             


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    290                 295                 300                 


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
305                 310                 315                 320 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                325                 330                 335     


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            340                 345                 350         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        355                 360                 365             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    370                 375                 380                 


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
385                 390                 395                 400 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                405                 410                 415     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            420                 425                 430         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        435                 440                 445             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    450                 455                 460                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475         


<210>  189
<211>  471
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having CETP signal peptide

<400>  189

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Asp Lys Thr Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg 
65                  70                  75                  80  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser 
                85                  90                  95      


Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser 
145                 150                 155                 160 


Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys 
    210                 215                 220                 


Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu 
225                 230                 235                 240 


Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
                245                 250                 255     


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            260                 265                 270         


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        275                 280                 285             


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    290                 295                 300                 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
305                 310                 315                 320 


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                325                 330                 335     


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            340                 345                 350         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        355                 360                 365             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
    370                 375                 380                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
385                 390                 395                 400 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                405                 410                 415     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            420                 425                 430         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        435                 440                 445             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    450                 455                 460                 


Leu Ser Leu Ser Pro Gly Lys 
465                 470     


<210>  190
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab heavy chain having the N-terminal sequence CDKTHT

<400>  190

Cys Asp Lys Thr His Thr Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
1               5                   10                  15      


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25                  30          


Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly 
        35                  40                  45              


Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr 
    50                  55                  60                  


Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
65                  70                  75                  80  


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
                85                  90                  95      


Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala 
            100                 105                 110         


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  191
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having SHH signal peptide

<400>  191

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Asp Lys Thr His Thr Glu Val Gln 
            20                  25                  30          


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
        35                  40                  45              


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
    50                  55                  60                  


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
65                  70                  75                  80  


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
                85                  90                  95      


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
            100                 105                 110         


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
        115                 120                 125             


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
    130                 135                 140                 


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
145                 150                 155                 160 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
                165                 170                 175     


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
            180                 185                 190         


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
        195                 200                 205             


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
    210                 215                 220                 


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
225                 230                 235                 240 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  192
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having IFN signal peptide

<400>  192

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Lys Thr His Thr Glu Val Gln 
            20                  25                  30          


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
        35                  40                  45              


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
    50                  55                  60                  


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
65                  70                  75                  80  


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
                85                  90                  95      


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
            100                 105                 110         


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
        115                 120                 125             


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
    130                 135                 140                 


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
145                 150                 155                 160 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
                165                 170                 175     


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
            180                 185                 190         


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
        195                 200                 205             


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
    210                 215                 220                 


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
225                 230                 235                 240 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  193
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having CETP signal peptide

<400>  193

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Asp Lys Thr His Thr Glu Val Gln Leu Val Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr 
65                  70                  75                  80  


Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp 
                85                  90                  95      


Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr 
        115                 120                 125             


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  194
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab heavy chain having the N-terminal sequence CVE

<400>  194

Cys Val Glu Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
            20                  25                  30          


Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala 
    50                  55                  60                  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn 
65                  70                  75                  80  


Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  195
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having SHH signal peptide

<400>  195

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Val Glu Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr 
65                  70                  75                  80  


Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp 
        115                 120                 125             


Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  196
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having IFN signal peptide

<400>  196

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Val Glu Glu Val Gln Leu Val Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr 
65                  70                  75                  80  


Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp 
        115                 120                 125             


Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
    130                 135                 140                 


Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 
145                 150                 155                 160 


Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 
                165                 170                 175     


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
            180                 185                 190         


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
        195                 200                 205             


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
    210                 215                 220                 


Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 
225                 230                 235                 240 


Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  197
<211>  470
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having CETP signal peptide

<400>  197

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Val Glu Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            20                  25                  30          


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn 
        35                  40                  45              


Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly 
    50                  55                  60                  


Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr 
65                  70                  75                  80  


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys 
                85                  90                  95      


Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            100                 105                 110         


Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
145                 150                 155                 160 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    210                 215                 220                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
225                 230                 235                 240 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                245                 250                 255     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            260                 265                 270         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        275                 280                 285             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    290                 295                 300                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
305                 310                 315                 320 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                325                 330                 335     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            340                 345                 350         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        355                 360                 365             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
    370                 375                 380                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
385                 390                 395                 400 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                405                 410                 415     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            420                 425                 430         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        435                 440                 445             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    450                 455                 460                 


Ser Leu Ser Pro Gly Lys 
465                 470 


<210>  198
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab heavy chain having the N-terminal sequence CDTPPP

<400>  198

Cys Asp Thr Pro Pro Pro Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
1               5                   10                  15      


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            20                  25                  30          


Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro Gly 
        35                  40                  45              


Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr 
    50                  55                  60                  


Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr 
65                  70                  75                  80  


Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
                85                  90                  95      


Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala 
            100                 105                 110         


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
        115                 120                 125             


Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr 
    130                 135                 140                 


Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro 
145                 150                 155                 160 


Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val 
                165                 170                 175     


His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser 
            180                 185                 190         


Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile 
        195                 200                 205             


Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val 
    210                 215                 220                 


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
225                 230                 235                 240 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  199
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having SHH signal peptide

<400>  199

Met Leu Leu Leu Ala Arg Cys Leu Leu Leu Val Leu Val Ser Ser Leu 
1               5                   10                  15      


Leu Val Cys Ser Gly Leu Ala Cys Asp Thr Pro Pro Pro Glu Val Gln 
            20                  25                  30          


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
        35                  40                  45              


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
    50                  55                  60                  


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
65                  70                  75                  80  


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
                85                  90                  95      


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
            100                 105                 110         


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
        115                 120                 125             


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
    130                 135                 140                 


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
145                 150                 155                 160 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
                165                 170                 175     


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
            180                 185                 190         


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
        195                 200                 205             


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
    210                 215                 220                 


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
225                 230                 235                 240 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  200
<211>  479
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having IFN signal peptide

<400>  200

Met Ala Leu Thr Phe Ala Leu Leu Val Ala Leu Leu Val Leu Ser Cys 
1               5                   10                  15      


Lys Ser Ser Cys Ser Val Gly Cys Asp Thr Pro Pro Pro Glu Val Gln 
            20                  25                  30          


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
        35                  40                  45              


Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
    50                  55                  60                  


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Arg Ile 
65                  70                  75                  80  


Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg 
                85                  90                  95      


Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met 
            100                 105                 110         


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp 
        115                 120                 125             


Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu 
    130                 135                 140                 


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
145                 150                 155                 160 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
                165                 170                 175     


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
            180                 185                 190         


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
        195                 200                 205             


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
    210                 215                 220                 


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
225                 230                 235                 240 


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
                245                 250                 255     


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
            260                 265                 270         


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
        275                 280                 285             


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
    290                 295                 300                 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
305                 310                 315                 320 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
                325                 330                 335     


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
            340                 345                 350         


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
        355                 360                 365             


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
    370                 375                 380                 


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
385                 390                 395                 400 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
                405                 410                 415     


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
            420                 425                 430         


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
        435                 440                 445             


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
    450                 455                 460                 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475                 


<210>  201
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  pre-heavy chain chimeric polypeptide having CETP signal peptide

<400>  201

Met Leu Ala Ala Thr Val Leu Thr Leu Ala Leu Leu Gly Asn Ala His 
1               5                   10                  15      


Ala Cys Asp Thr Pro Pro Pro Glu Val Gln Leu Val Glu Ser Gly Gly 
            20                  25                  30          


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        35                  40                  45              


Gly Phe Asn Ile Lys Asp Thr Tyr Ile His Trp Val Arg Gln Ala Pro 
    50                  55                  60                  


Gly Lys Gly Leu Glu Trp Val Ala Arg Ile Tyr Pro Thr Asn Gly Tyr 
65                  70                  75                  80  


Thr Arg Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Ala Asp 
                85                  90                  95      


Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
            100                 105                 110         


Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gly Asp Gly Phe Tyr 
        115                 120                 125             


Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala 
    130                 135                 140                 


Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser 
145                 150                 155                 160 


Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
                165                 170                 175     


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
            180                 185                 190         


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
        195                 200                 205             


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr 
    210                 215                 220                 


Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys 
225                 230                 235                 240 


Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  202
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  202

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  203
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  203
agaggtagta ggttgcatag tt                                                22


