                         SEQUENCE LISTING

<110>  RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
 
<120>  METHODS OF DELIVERING HEPARIN BINDING EPIDERMAL GROWTH FACTOR 
       USING STEM CELL GENERATED EXOCOMES

<130>  28335/48517A

<150>  61/952,632
<151>  2014-03-13

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  624
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(624)

<400>  1
atg aag ctg ctg ccg tcg gtg gtg ctg aag ctc ttt ctg gct gca gtt         48
Met Lys Leu Leu Pro Ser Val Val Leu Lys Leu Phe Leu Ala Ala Val           
1               5                   10                  15                

ctc tcg gca ctg gtg act ggc gag agc ctg gag cgg ctt cgg aga ggg         96
Leu Ser Ala Leu Val Thr Gly Glu Ser Leu Glu Arg Leu Arg Arg Gly           
            20                  25                  30                    

cta gct gct gga acc agc aac ccg gac cct ccc act gta tcc acg gac        144
Leu Ala Ala Gly Thr Ser Asn Pro Asp Pro Pro Thr Val Ser Thr Asp           
        35                  40                  45                        

cag ctg cta ccc cta gga ggc ggc cgg gac cgg aaa gtc cgt gac ttg        192
Gln Leu Leu Pro Leu Gly Gly Gly Arg Asp Arg Lys Val Arg Asp Leu           
    50                  55                  60                            

caa gag gca gat ctg gac ctt ttg aga gtc act tta tcc tcc aag cca        240
Gln Glu Ala Asp Leu Asp Leu Leu Arg Val Thr Leu Ser Ser Lys Pro           
65                  70                  75                  80            

caa gca ctg gcc aca cca aac aag gag gag cac ggg aaa aga aag aag        288
Gln Ala Leu Ala Thr Pro Asn Lys Glu Glu His Gly Lys Arg Lys Lys           
                85                  90                  95                

aaa ggc aag ggg cta ggg aag aag agg gac cca tgt ctt cgg aaa tac        336
Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg Lys Tyr           
            100                 105                 110                   

aag gac ttc tgc atc cat gga gaa tgc aaa tat gtg aag gag ctc cgg        384
Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu Leu Arg           
        115                 120                 125                       

gct ccc tcc tgc atc tgc cac ccg ggt tac cat gga gag agg tgt cat        432
Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg Cys His           
    130                 135                 140                           

ggg ctg agc ctc cca gtg gaa aat cgc tta tat acc tat gac cac aca        480
Gly Leu Ser Leu Pro Val Glu Asn Arg Leu Tyr Thr Tyr Asp His Thr           
145                 150                 155                 160           

acc atc ctg gcc gtg gtg gct gtg gtg ctg tca tct gtc tgt ctg ctg        528
Thr Ile Leu Ala Val Val Ala Val Val Leu Ser Ser Val Cys Leu Leu           
                165                 170                 175               

gtc atc gtg ggg ctt ctc atg ttt agg tac cat agg aga gga ggt tat        576
Val Ile Val Gly Leu Leu Met Phe Arg Tyr His Arg Arg Gly Gly Tyr           
            180                 185                 190                   

gat gtg gaa aat gaa gag aaa gtg aag ttg ggc atg act aat tcc cac        624
Asp Val Glu Asn Glu Glu Lys Val Lys Leu Gly Met Thr Asn Ser His           
        195                 200                 205                       


<210>  2
<211>  208
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Leu Leu Pro Ser Val Val Leu Lys Leu Phe Leu Ala Ala Val 
1               5                   10                  15      


Leu Ser Ala Leu Val Thr Gly Glu Ser Leu Glu Arg Leu Arg Arg Gly 
            20                  25                  30          


Leu Ala Ala Gly Thr Ser Asn Pro Asp Pro Pro Thr Val Ser Thr Asp 
        35                  40                  45              


Gln Leu Leu Pro Leu Gly Gly Gly Arg Asp Arg Lys Val Arg Asp Leu 
    50                  55                  60                  


Gln Glu Ala Asp Leu Asp Leu Leu Arg Val Thr Leu Ser Ser Lys Pro 
65                  70                  75                  80  


Gln Ala Leu Ala Thr Pro Asn Lys Glu Glu His Gly Lys Arg Lys Lys 
                85                  90                  95      


Lys Gly Lys Gly Leu Gly Lys Lys Arg Asp Pro Cys Leu Arg Lys Tyr 
            100                 105                 110         


Lys Asp Phe Cys Ile His Gly Glu Cys Lys Tyr Val Lys Glu Leu Arg 
        115                 120                 125             


Ala Pro Ser Cys Ile Cys His Pro Gly Tyr His Gly Glu Arg Cys His 
    130                 135                 140                 


Gly Leu Ser Leu Pro Val Glu Asn Arg Leu Tyr Thr Tyr Asp His Thr 
145                 150                 155                 160 


Thr Ile Leu Ala Val Val Ala Val Val Leu Ser Ser Val Cys Leu Leu 
                165                 170                 175     


Val Ile Val Gly Leu Leu Met Phe Arg Tyr His Arg Arg Gly Gly Tyr 
            180                 185                 190         


Asp Val Glu Asn Glu Glu Lys Val Lys Leu Gly Met Thr Asn Ser His 
        195                 200                 205             


<210>  3
<211>  4913
<212>  DNA
<213>  Homo sapiens

<400>  3
aaaaagagaa actgttggga gaggaatcgt atctccatat ttcttctttc agccccaatc       60

caagggttgt agctggaact ttccatcagt tcttcctttc tttttcctct ctaagccttt      120

gccttgctct gtcacagtga agtcagccag agcagggctg ttaaactctg tgaaatttgt      180

cataagggtg tcaggtattt cttactggct tccaaagaaa catagataaa gaaatctttc      240

ctgtggcttc ccttggcagg ctgcattcag aaggtctctc agttgaagaa agagcttgga      300

ggacaacagc acaacaggag agtaaaagat gccccagggc tgaggcctcc gctcaggcag      360

ccgcatctgg ggtcaatcat actcaccttg cccgggccat gctccagcaa aatcaagctg      420

ttttcttttg aaagttcaaa ctcatcaaga ttatgctgct cactcttatc attctgttgc      480

cagtagtttc aaaatttagt tttgttagtc tctcagcacc gcagcactgg agctgtcctg      540

aaggtactct cgcaggaaat gggaattcta cttgtgtggg tcctgcaccc ttcttaattt      600

tctcccatgg aaatagtatc tttaggattg acacagaagg aaccaattat gagcaattgg      660

tggtggatgc tggtgtctca gtgatcatgg attttcatta taatgagaaa agaatctatt      720

gggtggattt agaaagacaa cttttgcaaa gagtttttct gaatgggtca aggcaagaga      780

gagtatgtaa tatagagaaa aatgtttctg gaatggcaat aaattggata aatgaagaag      840

ttatttggtc aaatcaacag gaaggaatca ttacagtaac agatatgaaa ggaaataatt      900

cccacattct tttaagtgct ttaaaatatc ctgcaaatgt agcagttgat ccagtagaaa      960

ggtttatatt ttggtcttca gaggtggctg gaagccttta tagagcagat ctcgatggtg     1020

tgggagtgaa ggctctgttg gagacatcag agaaaataac agctgtgtca ttggatgtgc     1080

ttgataagcg gctgttttgg attcagtaca acagagaagg aagcaattct cttatttgct     1140

cctgtgatta tgatggaggt tctgtccaca ttagtaaaca tccaacacag cataatttgt     1200

ttgcaatgtc cctttttggt gaccgtatct tctattcaac atggaaaatg aagacaattt     1260

ggatagccaa caaacacact ggaaaggaca tggttagaat taacctccat tcatcatttg     1320

taccacttgg tgaactgaaa gtagtgcatc cacttgcaca acccaaggca gaagatgaca     1380

cttgggagcc tgagcagaaa ctttgcaaat tgaggaaagg aaactgcagc agcactgtgt     1440

gtgggcaaga cctccagtca cacttgtgca tgtgtgcaga gggatacgcc ctaagtcgag     1500

accggaagta ctgtgaagat gttaatgaat gtgctttttg gaatcatggc tgtactcttg     1560

ggtgtaaaaa cacccctgga tcctattact gcacgtgccc tgtaggattt gttctgcttc     1620

ctgatgggaa acgatgtcat caacttgttt cctgtccacg caatgtgtct gaatgcagcc     1680

atgactgtgt tctgacatca gaaggtccct tatgtttctg tcctgaaggc tcagtgcttg     1740

agagagatgg gaaaacatgt agcggttgtt cctcacccga taatggtgga tgtagccagc     1800

tctgcgttcc tcttagccca gtatcctggg aatgtgattg ctttcctggg tatgacctac     1860

aactggatga aaaaagctgt gcagcttcag gaccacaacc atttttgctg tttgccaatt     1920

ctcaagatat tcgacacatg cattttgatg gaacagacta tggaactctg ctcagccagc     1980

agatgggaat ggtttatgcc ctagatcatg accctgtgga aaataagata tactttgccc     2040

atacagccct gaagtggata gagagagcta atatggatgg ttcccagcga gaaaggctta     2100

ttgaggaagg agtagatgtg ccagaaggtc ttgctgtgga ctggattggc cgtagattct     2160

attggacaga cagagggaaa tctctgattg gaaggagtga tttaaatggg aaacgttcca     2220

aaataatcac taaggagaac atctctcaac cacgaggaat tgctgttcat ccaatggcca     2280

agagattatt ctggactgat acagggatta atccacgaat tgaaagttct tccctccaag     2340

gccttggccg tctggttata gccagctctg atctaatctg gcccagtgga ataacgattg     2400

acttcttaac tgacaagttg tactggtgcg atgccaagca gtctgtgatt gaaatggcca     2460

atctggatgg ttcaaaacgc cgaagactta cccagaatga tgtaggtcac ccatttgctg     2520

tagcagtgtt tgaggattat gtgtggttct cagattgggc tatgccatca gtaatgagag     2580

taaacaagag gactggcaaa gatagagtac gtctccaagg cagcatgctg aagccctcat     2640

cactggttgt ggttcatcca ttggcaaaac caggagcaga tccctgctta tatcaaaacg     2700

gaggctgtga acatatttgc aaaaagaggc ttggaactgc ttggtgttcg tgtcgtgaag     2760

gttttatgaa agcctcagat gggaaaacgt gtctggctct ggatggtcat cagctgttgg     2820

caggtggtga agttgatcta aagaaccaag taacaccatt ggacatcttg tccaagacta     2880

gagtgtcaga agataacatt acagaatctc aacacatgct agtggctgaa atcatggtgt     2940

cagatcaaga tgactgtgct cctgtgggat gcagcatgta tgctcggtgt atttcagagg     3000

gagaggatgc cacatgtcag tgtttgaaag gatttgctgg ggatggaaaa ctatgttctg     3060

atatagatga atgtgagatg ggtgtcccag tgtgcccccc tgcctcctcc aagtgcatca     3120

acaccgaagg tggttatgtc tgccggtgct cagaaggcta ccaaggagat gggattcact     3180

gtcttgatat tgatgagtgc caactggggg agcacagctg tggagagaat gccagctgca     3240

caaatacaga gggaggctat acctgcatgt gtgctggacg cctgtctgaa ccaggactga     3300

tttgccctga ctctactcca ccccctcacc tcagggaaga tgaccaccac tattccgtaa     3360

gaaatagtga ctctgaatgt cccctgtccc acgatgggta ctgcctccat gatggtgtgt     3420

gcatgtatat tgaagcattg gacaagtatg catgcaactg tgttgttggc tacatcgggg     3480

agcgatgtca gtaccgagac ctgaagtggt gggaactgcg ccacgctggc cacgggcagc     3540

agcagaaggt catcgtggtg gctgtctgcg tggtggtgct tgtcatgctg ctcctcctga     3600

gcctgtgggg ggcccactac tacaggactc agaagctgct atcgaaaaac ccaaagaatc     3660

cttatgagga gtcgagcaga gatgtgagga gtcgcaggcc tgctgacact gaggatggga     3720

tgtcctcttg ccctcaacct tggtttgtgg ttataaaaga acaccaagac ctcaagaatg     3780

ggggtcaacc agtggctggt gaggatggcc aggcagcaga tgggtcaatg caaccaactt     3840

catggaggca ggagccccag ttatgtggaa tgggcacaga gcaaggctgc tggattccag     3900

tatccagtga taagggctcc tgtccccagg taatggagcg aagctttcat atgccctcct     3960

atgggacaca gacccttgaa gggggtgtcg agaagcccca ttctctccta tcagctaacc     4020

cattatggca acaaagggcc ctggacccac cacaccaaat ggagctgact cagtgaaaac     4080

tggaattaaa aggaaagtca agaagaatga actatgtcga tgcacagtat cttttctttc     4140

aaaagtagag caaaactata ggttttggtt ccacaatctc tacgactaat cacctactca     4200

atgcctggag acagatacgt agttgtgctt ttgtttgctc ttttaagcag tctcactgca     4260

gtcttatttc caagtaagag tactgggaga atcactaggt aacttattag aaacccaaat     4320

tgggacaaca gtgctttgta aattgtgttg tcttcagcag tcaatacaaa tagatttttg     4380

tttttgttgt tcctgcagcc ccagaagaaa ttaggggtta aagcagacag tcacactggt     4440

ttggtcagtt acaaagtaat ttctttgatc tggacagaac atttatatca gtttcatgaa     4500

atgattggaa tattacaata ccgttaagat acagtgtagg catttaactc ctcattggcg     4560

tggtccatgc tgatgatttt gcaaaatgag ttgtgatgaa tcaatgaaaa atgtaattta     4620

gaaactgatt tcttcagaat tagatggctt attttttaaa atatttgaat gaaaacattt     4680

tatttttaaa atattacaca ggaggcttcg gagtttctta gtcattactg tccttttccc     4740

ctacagaatt ttccctcttg gtgtgattgc acagaatttg tatgtatttt cagttacaag     4800

attgtaagta aattgcctga tttgttttca ttatagacaa cgatgaattt cttctaatta     4860

tttaaataaa atcaccaaaa acataaaaaa aaaaaaaaaa aaaaaaaaaa aaa            4913


<210>  4
<211>  1207
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Leu Thr Leu Ile Ile Leu Leu Pro Val Val Ser Lys Phe Ser 
1               5                   10                  15      


Phe Val Ser Leu Ser Ala Pro Gln His Trp Ser Cys Pro Glu Gly Thr 
            20                  25                  30          


Leu Ala Gly Asn Gly Asn Ser Thr Cys Val Gly Pro Ala Pro Phe Leu 
        35                  40                  45              


Ile Phe Ser His Gly Asn Ser Ile Phe Arg Ile Asp Thr Glu Gly Thr 
    50                  55                  60                  


Asn Tyr Glu Gln Leu Val Val Asp Ala Gly Val Ser Val Ile Met Asp 
65                  70                  75                  80  


Phe His Tyr Asn Glu Lys Arg Ile Tyr Trp Val Asp Leu Glu Arg Gln 
                85                  90                  95      


Leu Leu Gln Arg Val Phe Leu Asn Gly Ser Arg Gln Glu Arg Val Cys 
            100                 105                 110         


Asn Ile Glu Lys Asn Val Ser Gly Met Ala Ile Asn Trp Ile Asn Glu 
        115                 120                 125             


Glu Val Ile Trp Ser Asn Gln Gln Glu Gly Ile Ile Thr Val Thr Asp 
    130                 135                 140                 


Met Lys Gly Asn Asn Ser His Ile Leu Leu Ser Ala Leu Lys Tyr Pro 
145                 150                 155                 160 


Ala Asn Val Ala Val Asp Pro Val Glu Arg Phe Ile Phe Trp Ser Ser 
                165                 170                 175     


Glu Val Ala Gly Ser Leu Tyr Arg Ala Asp Leu Asp Gly Val Gly Val 
            180                 185                 190         


Lys Ala Leu Leu Glu Thr Ser Glu Lys Ile Thr Ala Val Ser Leu Asp 
        195                 200                 205             


Val Leu Asp Lys Arg Leu Phe Trp Ile Gln Tyr Asn Arg Glu Gly Ser 
    210                 215                 220                 


Asn Ser Leu Ile Cys Ser Cys Asp Tyr Asp Gly Gly Ser Val His Ile 
225                 230                 235                 240 


Ser Lys His Pro Thr Gln His Asn Leu Phe Ala Met Ser Leu Phe Gly 
                245                 250                 255     


Asp Arg Ile Phe Tyr Ser Thr Trp Lys Met Lys Thr Ile Trp Ile Ala 
            260                 265                 270         


Asn Lys His Thr Gly Lys Asp Met Val Arg Ile Asn Leu His Ser Ser 
        275                 280                 285             


Phe Val Pro Leu Gly Glu Leu Lys Val Val His Pro Leu Ala Gln Pro 
    290                 295                 300                 


Lys Ala Glu Asp Asp Thr Trp Glu Pro Glu Gln Lys Leu Cys Lys Leu 
305                 310                 315                 320 


Arg Lys Gly Asn Cys Ser Ser Thr Val Cys Gly Gln Asp Leu Gln Ser 
                325                 330                 335     


His Leu Cys Met Cys Ala Glu Gly Tyr Ala Leu Ser Arg Asp Arg Lys 
            340                 345                 350         


Tyr Cys Glu Asp Val Asn Glu Cys Ala Phe Trp Asn His Gly Cys Thr 
        355                 360                 365             


Leu Gly Cys Lys Asn Thr Pro Gly Ser Tyr Tyr Cys Thr Cys Pro Val 
    370                 375                 380                 


Gly Phe Val Leu Leu Pro Asp Gly Lys Arg Cys His Gln Leu Val Ser 
385                 390                 395                 400 


Cys Pro Arg Asn Val Ser Glu Cys Ser His Asp Cys Val Leu Thr Ser 
                405                 410                 415     


Glu Gly Pro Leu Cys Phe Cys Pro Glu Gly Ser Val Leu Glu Arg Asp 
            420                 425                 430         


Gly Lys Thr Cys Ser Gly Cys Ser Ser Pro Asp Asn Gly Gly Cys Ser 
        435                 440                 445             


Gln Leu Cys Val Pro Leu Ser Pro Val Ser Trp Glu Cys Asp Cys Phe 
    450                 455                 460                 


Pro Gly Tyr Asp Leu Gln Leu Asp Glu Lys Ser Cys Ala Ala Ser Gly 
465                 470                 475                 480 


Pro Gln Pro Phe Leu Leu Phe Ala Asn Ser Gln Asp Ile Arg His Met 
                485                 490                 495     


His Phe Asp Gly Thr Asp Tyr Gly Thr Leu Leu Ser Gln Gln Met Gly 
            500                 505                 510         


Met Val Tyr Ala Leu Asp His Asp Pro Val Glu Asn Lys Ile Tyr Phe 
        515                 520                 525             


Ala His Thr Ala Leu Lys Trp Ile Glu Arg Ala Asn Met Asp Gly Ser 
    530                 535                 540                 


Gln Arg Glu Arg Leu Ile Glu Glu Gly Val Asp Val Pro Glu Gly Leu 
545                 550                 555                 560 


Ala Val Asp Trp Ile Gly Arg Arg Phe Tyr Trp Thr Asp Arg Gly Lys 
                565                 570                 575     


Ser Leu Ile Gly Arg Ser Asp Leu Asn Gly Lys Arg Ser Lys Ile Ile 
            580                 585                 590         


Thr Lys Glu Asn Ile Ser Gln Pro Arg Gly Ile Ala Val His Pro Met 
        595                 600                 605             


Ala Lys Arg Leu Phe Trp Thr Asp Thr Gly Ile Asn Pro Arg Ile Glu 
    610                 615                 620                 


Ser Ser Ser Leu Gln Gly Leu Gly Arg Leu Val Ile Ala Ser Ser Asp 
625                 630                 635                 640 


Leu Ile Trp Pro Ser Gly Ile Thr Ile Asp Phe Leu Thr Asp Lys Leu 
                645                 650                 655     


Tyr Trp Cys Asp Ala Lys Gln Ser Val Ile Glu Met Ala Asn Leu Asp 
            660                 665                 670         


Gly Ser Lys Arg Arg Arg Leu Thr Gln Asn Asp Val Gly His Pro Phe 
        675                 680                 685             


Ala Val Ala Val Phe Glu Asp Tyr Val Trp Phe Ser Asp Trp Ala Met 
    690                 695                 700                 


Pro Ser Val Met Arg Val Asn Lys Arg Thr Gly Lys Asp Arg Val Arg 
705                 710                 715                 720 


Leu Gln Gly Ser Met Leu Lys Pro Ser Ser Leu Val Val Val His Pro 
                725                 730                 735     


Leu Ala Lys Pro Gly Ala Asp Pro Cys Leu Tyr Gln Asn Gly Gly Cys 
            740                 745                 750         


Glu His Ile Cys Lys Lys Arg Leu Gly Thr Ala Trp Cys Ser Cys Arg 
        755                 760                 765             


Glu Gly Phe Met Lys Ala Ser Asp Gly Lys Thr Cys Leu Ala Leu Asp 
    770                 775                 780                 


Gly His Gln Leu Leu Ala Gly Gly Glu Val Asp Leu Lys Asn Gln Val 
785                 790                 795                 800 


Thr Pro Leu Asp Ile Leu Ser Lys Thr Arg Val Ser Glu Asp Asn Ile 
                805                 810                 815     


Thr Glu Ser Gln His Met Leu Val Ala Glu Ile Met Val Ser Asp Gln 
            820                 825                 830         


Asp Asp Cys Ala Pro Val Gly Cys Ser Met Tyr Ala Arg Cys Ile Ser 
        835                 840                 845             


Glu Gly Glu Asp Ala Thr Cys Gln Cys Leu Lys Gly Phe Ala Gly Asp 
    850                 855                 860                 


Gly Lys Leu Cys Ser Asp Ile Asp Glu Cys Glu Met Gly Val Pro Val 
865                 870                 875                 880 


Cys Pro Pro Ala Ser Ser Lys Cys Ile Asn Thr Glu Gly Gly Tyr Val 
                885                 890                 895     


Cys Arg Cys Ser Glu Gly Tyr Gln Gly Asp Gly Ile His Cys Leu Asp 
            900                 905                 910         


Ile Asp Glu Cys Gln Leu Gly Glu His Ser Cys Gly Glu Asn Ala Ser 
        915                 920                 925             


Cys Thr Asn Thr Glu Gly Gly Tyr Thr Cys Met Cys Ala Gly Arg Leu 
    930                 935                 940                 


Ser Glu Pro Gly Leu Ile Cys Pro Asp Ser Thr Pro Pro Pro His Leu 
945                 950                 955                 960 


Arg Glu Asp Asp His His Tyr Ser Val Arg Asn Ser Asp Ser Glu Cys 
                965                 970                 975     


Pro Leu Ser His Asp Gly Tyr Cys Leu His Asp Gly Val Cys Met Tyr 
            980                 985                 990         


Ile Glu Ala Leu Asp Lys Tyr Ala  Cys Asn Cys Val Val  Gly Tyr Ile 
        995                 1000                 1005             


Gly Glu  Arg Cys Gln Tyr Arg  Asp Leu Lys Trp Trp  Glu Leu Arg 
    1010                 1015                 1020             


His Ala  Gly His Gly Gln Gln  Gln Lys Val Ile Val  Val Ala Val 
    1025                 1030                 1035             


Cys Val  Val Val Leu Val Met  Leu Leu Leu Leu Ser  Leu Trp Gly 
    1040                 1045                 1050             


Ala His  Tyr Tyr Arg Thr Gln  Lys Leu Leu Ser Lys  Asn Pro Lys 
    1055                 1060                 1065             


Asn Pro  Tyr Glu Glu Ser Ser  Arg Asp Val Arg Ser  Arg Arg Pro 
    1070                 1075                 1080             


Ala Asp  Thr Glu Asp Gly Met  Ser Ser Cys Pro Gln  Pro Trp Phe 
    1085                 1090                 1095             


Val Val  Ile Lys Glu His Gln  Asp Leu Lys Asn Gly  Gly Gln Pro 
    1100                 1105                 1110             


Val Ala  Gly Glu Asp Gly Gln  Ala Ala Asp Gly Ser  Met Gln Pro 
    1115                 1120                 1125             


Thr Ser  Trp Arg Gln Glu Pro  Gln Leu Cys Gly Met  Gly Thr Glu 
    1130                 1135                 1140             


Gln Gly  Cys Trp Ile Pro Val  Ser Ser Asp Lys Gly  Ser Cys Pro 
    1145                 1150                 1155             


Gln Val  Met Glu Arg Ser Phe  His Met Pro Ser Tyr  Gly Thr Gln 
    1160                 1165                 1170             


Thr Leu  Glu Gly Gly Val Glu  Lys Pro His Ser Leu  Leu Ser Ala 
    1175                 1180                 1185             


Asn Pro  Leu Trp Gln Gln Arg  Ala Leu Asp Pro Pro  His Gln Met 
    1190                 1195                 1200             


Glu Leu  Thr Gln 
    1205         


<210>  5
<211>  4261
<212>  DNA
<213>  Homo sapiens

<400>  5
agccgccttc ctatttccgc ccggcgggca gcgctgcggg gcgagtgcca gcagagaggc       60

gctcggtcct ccctccgccc tcccgcgccg ggggcaggcc ctgcctagtc tgcgtctttt      120

tcccccgcac cgcggcgccg ctccgccact cgggcaccgc aggtagggca ggaggctgga      180

gagcctgctg cccgcccgcc cgtaaaatgg tcccctcggc tggacagctc gccctgttcg      240

ctctgggtat tgtgttggct gcgtgccagg ccttggagaa cagcacgtcc ccgctgagtg      300

acccgcccgt ggctgcagca gtggtgtccc attttaatga ctgcccagat tcccacactc      360

agttctgctt ccatggaacc tgcaggtttt tggtgcagga ggacaagcca gcatgtgtct      420

gccattctgg gtacgttggt gcacgctgtg agcatgcgga cctcctggcc gtggtggctg      480

ccagccagaa gaagcaggcc atcaccgcct tggtggtggt ctccatcgtg gccctggctg      540

tccttatcat cacatgtgtg ctgatacact gctgccaggt ccgaaaacac tgtgagtggt      600

gccgggccct catctgccgg cacgagaagc ccagcgccct cctgaaggga agaaccgctt      660

gctgccactc agaaacagtg gtctgaagag cccagaggag gagtttggcc aggtggactg      720

tggcagatca ataaagaaag gcttcttcag gacagcactg ccagagatgc ctgggtgtgc      780

cacagacctt cctacttggc ctgtaatcac ctgtgcagcc ttttgtgggc cttcaaaact      840

ctgtcaagaa ctccgtctgc ttggggttat tcagtgtgac ctagagaaga aatcagcgga      900

ccacgatttc aagacttgtt aaaaaagaac tgcaaagaga cggactcctg ttcacctagg      960

tgaggtgtgt gcagcagttg gtgtctgagt ccacatgtgt gcagttgtct tctgccagcc     1020

atggattcca ggctatatat ttctttttaa tgggccacct ccccacaaca gaattctgcc     1080

caacacagga gatttctata gttattgttt tctgtcattt gcctactggg gaagaaagtg     1140

aaggagggga aactgtttaa tatcacatga agaccctagc tttaagagaa gctgtatcct     1200

ctaaccacga gaccctcaac cagcccaaca tcttccatgg acacatgaca ttgaagacca     1260

tcccaagcta tcgccaccct tggagatgat gtcttattta ttagatggat aatggtttta     1320

tttttaatct cttaagtcaa tgtaaaaagt ataaaacccc ttcagacttc tacattaatg     1380

atgtatgtgt tgctgactga aaagctatac tgattagaaa tgtctggcct cttcaagaca     1440

gctaaggctt gggaaaagtc ttccagggtg cggagatgga accagaggct gggttactgg     1500

taggaataaa ggtaggggtt cagaaatggt gccattgaag ccacaaagcc ggtaaatgcc     1560

tcaatacgtt ctgggagaaa acttagcaaa tccatcagca gggatctgtc ccctctgttg     1620

gggagagagg aagagtgtgt gtgtctacac aggataaacc caatacatat tgtactgctc     1680

agtgattaaa tgggttcact tcctcgtgag ccctcggtaa gtatgtttag aaatagaaca     1740

ttagccacga gccataggca tttcaggcca aatccatgaa agggggacca gtcatttatt     1800

ttccattttg ttgcttggtt ggtttgttgc tttattttta aaaggagaag tttaactttg     1860

ctatttattt tcgagcacta ggaaaactat tccagtaatt tttttttcct catttccatt     1920

caggatgccg gctttattaa caaaaactct aacaagtcac ctccactatg tgggtcttcc     1980

tttcccctca agagaaggag caattgttcc cctgagcatc tgggtccatc tgacccatgg     2040

ggcctgcctg tgagaaacag tgggtccctt caaatacata gtggatagct catccctagg     2100

aattttcatt aaaatttgga aacagagtaa tgaagaaata atatataaac tccttatgtg     2160

aggaaatgct actaatatct gaaaagtgaa agatttctat gtattaactc ttaagtgcac     2220

ctagcttatt acatcgtgaa aggtacattt aaaatatgtt aaattggctt gaaattttca     2280

gagaattttg tcttccccta attcttcttc cttggtctgg aagaacaatt tctatgaatt     2340

ttctctttat ttttttttat aattcagaca attctatgac ccgtgtcttc atttttggca     2400

ctcttattta acaatgccac acctgaagca cttggatctg ttcagagctg accccctagc     2460

aacgtagttg acacagctcc aggtttttaa attactaaaa taagttcaag tttacatccc     2520

ttgggccaga tatgtgggtt gaggcttgac tgtagcatcc tgcttagaga ccaatcaacg     2580

gacactggtt tttagacctc tatcaatcag tagttagcat ccaagagact ttgcagaggc     2640

gtaggaatga ggctggacag atggcggaag cagaggttcc ctgcgaagac ttgagattta     2700

gtgtctgtga atgttctagt tcctaggtcc agcaagtcac acctgccagt gccctcatcc     2760

ttatgcctgt aacacacatg cagtgagagg cctcacatat acgcctccct agaagtgcct     2820

tccaagtcag tcctttggaa accagcaggt ctgaaaaaga ggctgcatca atgcaagcct     2880

ggttggacca ttgtccatgc ctcaggatag aacagcctgg cttatttggg gatttttctt     2940

ctagaaatca aatgactgat aagcattgga tccctctgcc atttaatggc aatggtagtc     3000

tttggttagc tgcaaaaata ctccatttca agttaaaaat gcatcttcta atccatctct     3060

gcaagctccc tgtgtttcct tgccctttag aaaatgaatt gttcactaca attagagaat     3120

catttaacat cctgacctgg taagctgcca cacacctggc agtggggagc atcgctgttt     3180

ccaatggctc aggagacaat gaaaagcccc catttaaaaa aataacaaac attttttaaa     3240

aggcctccaa tactcttatg gagcctggat ttttcccact gctctacagg ctgtgacttt     3300

ttttaagcat cctgacagga aatgttttct tctacatgga aagatagaca gcagccaacc     3360

ctgatctgga agacagggcc ccggctggac acacgtggaa ccaagccagg gatgggctgg     3420

ccattgtgtc cccgcaggag agatgggcag aatggcccta gagttctttt ccctgagaaa     3480

ggagaaaaag atgggattgc cactcaccca cccacactgg taagggagga gaatttgtgc     3540

ttctggagct tctcaaggga ttgtgttttg caggtacaga aaactgcctg ttatcttcaa     3600

gccaggtttt cgagggcaca tgggtcacca gttgcttttt cagtcaattt ggccgggatg     3660

gactaatgag gctctaacac tgctcaggag acccctgccc tctagttggt tctgggcttt     3720

gatctcttcc aacctgccca gtcacagaag gaggaatgac tcaaatgccc aaaaccaaga     3780

acacattgca gaagtaagac aaacatgtat atttttaaat gttctaacat aagacctgtt     3840

ctctctagcc attgatttac caggctttct gaaagatcta gtggttcaca cagagagaga     3900

gagagtactg aaaaagcaac tcctcttctt agtcttaata atttactaaa atggtcaact     3960

tttcattatc tttattataa taaacctgat gctttttttt agaactcctt actctgatgt     4020

ctgtatatgt tgcactgaaa aggttaatat ttaatgtttt aatttatttt gtgtggtaag     4080

ttaattttga tttctgtaat gtgttaatgt gattagcagt tattttcctt aatatctgaa     4140

ttatacttaa agagtagtga gcaatataag acgcaattgt gtttttcagt aatgtgcatt     4200

gttattgagt tgtactgtac cttatttgga aggatgaagg aatgaatctt tttttcctaa     4260

a                                                                     4261


<210>  6
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Val Pro Ser Ala Gly Gln Leu Ala Leu Phe Ala Leu Gly Ile Val 
1               5                   10                  15      


Leu Ala Ala Cys Gln Ala Leu Glu Asn Ser Thr Ser Pro Leu Ser Asp 
            20                  25                  30          


Pro Pro Val Ala Ala Ala Val Val Ser His Phe Asn Asp Cys Pro Asp 
        35                  40                  45              


Ser His Thr Gln Phe Cys Phe His Gly Thr Cys Arg Phe Leu Val Gln 
    50                  55                  60                  


Glu Asp Lys Pro Ala Cys Val Cys His Ser Gly Tyr Val Gly Ala Arg 
65                  70                  75                  80  


Cys Glu His Ala Asp Leu Leu Ala Val Val Ala Ala Ser Gln Lys Lys 
                85                  90                  95      


Gln Ala Ile Thr Ala Leu Val Val Val Ser Ile Val Ala Leu Ala Val 
            100                 105                 110         


Leu Ile Ile Thr Cys Val Leu Ile His Cys Cys Gln Val Arg Lys His 
        115                 120                 125             


Cys Glu Trp Cys Arg Ala Leu Ile Cys Arg His Glu Lys Pro Ser Ala 
    130                 135                 140                 


Leu Leu Lys Gly Arg Thr Ala Cys Cys His Ser Glu Thr Val Val 
145                 150                 155                 


<210>  7
<211>  1270
<212>  DNA
<213>  Homo sapiens

<400>  7
agacgttcgc acacctgggt gccagcgccc cagaggtccc gggacagccc gaggcgccgc       60

gcccgccgcc ccgagctccc caagccttcg agagcggcgc acactcccgg tctccactcg      120

ctcttccaac acccgctcgt tttggcggca gctcgtgtcc cagagaccga gttgccccag      180

agaccgagac gccgccgctg cgaaggacca atgagagccc cgctgctacc gccggcgccg      240

gtggtgctgt cgctcttgat actcggctca ggccattatg ctgctggatt ggacctcaat      300

gacacctact ctgggaagcg tgaaccattt tctggggacc acagtgctga tggatttgag      360

gttacctcaa gaagtgagat gtcttcaggg agtgagattt cccctgtgag tgaaatgcct      420

tctagtagtg aaccgtcctc gggagccgac tatgactact cagaagagta tgataacgaa      480

ccacaaatac ctggctatat tgtcgatgat tcagtcagag ttgaacaggt agttaagccc      540

ccccaaaaca agacggaaag tgaaaatact tcagataaac ccaaaagaaa gaaaaaggga      600

ggcaaaaatg gaaaaaatag aagaaacaga aagaagaaaa atccatgtaa tgcagaattt      660

caaaatttct gcattcacgg agaatgcaaa tatatagagc acctggaagc agtaacatgc      720

aaatgtcagc aagaatattt cggtgaacgg tgtggggaaa agtccatgaa aactcacagc      780

atgattgaca gtagtttatc aaaaattgca ttagcagcca tagctgcctt tatgtctgct      840

gtgatcctca cagctgttgc tgttattaca gtccagctta gaagacaata cgtcaggaaa      900

tatgaaggag aagctgagga acgaaagaaa cttcgacaag agaatggaaa tgtacatgct      960

atagcataac tgaagataaa attacaggat atcacattgg agtcactgcc aagtcatagc     1020

cataaatgat gagtcggtcc tctttccagt ggatcataag acaatggacc ctttttgtta     1080

tgatggtttt aaactttcaa ttgtcacttt ttatgctatt tctgtatata aaggtgcacg     1140

aaggtaaaaa gtattttttc aagttgtaaa taatttattt aatatttaat ggaagtgtat     1200

ttattttaca gctcattaaa cttttttaac caaacagaaa aaaaaaaaaa aaaaaaaaaa     1260

aaaaaaaaaa                                                            1270


<210>  8
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Ala Pro Leu Leu Pro Pro Ala Pro Val Val Leu Ser Leu Leu 
1               5                   10                  15      


Ile Leu Gly Ser Gly His Tyr Ala Ala Gly Leu Asp Leu Asn Asp Thr 
            20                  25                  30          


Tyr Ser Gly Lys Arg Glu Pro Phe Ser Gly Asp His Ser Ala Asp Gly 
        35                  40                  45              


Phe Glu Val Thr Ser Arg Ser Glu Met Ser Ser Gly Ser Glu Ile Ser 
    50                  55                  60                  


Pro Val Ser Glu Met Pro Ser Ser Ser Glu Pro Ser Ser Gly Ala Asp 
65                  70                  75                  80  


Tyr Asp Tyr Ser Glu Glu Tyr Asp Asn Glu Pro Gln Ile Pro Gly Tyr 
                85                  90                  95      


Ile Val Asp Asp Ser Val Arg Val Glu Gln Val Val Lys Pro Pro Gln 
            100                 105                 110         


Asn Lys Thr Glu Ser Glu Asn Thr Ser Asp Lys Pro Lys Arg Lys Lys 
        115                 120                 125             


Lys Gly Gly Lys Asn Gly Lys Asn Arg Arg Asn Arg Lys Lys Lys Asn 
    130                 135                 140                 


Pro Cys Asn Ala Glu Phe Gln Asn Phe Cys Ile His Gly Glu Cys Lys 
145                 150                 155                 160 


Tyr Ile Glu His Leu Glu Ala Val Thr Cys Lys Cys Gln Gln Glu Tyr 
                165                 170                 175     


Phe Gly Glu Arg Cys Gly Glu Lys Ser Met Lys Thr His Ser Met Ile 
            180                 185                 190         


Asp Ser Ser Leu Ser Lys Ile Ala Leu Ala Ala Ile Ala Ala Phe Met 
        195                 200                 205             


Ser Ala Val Ile Leu Thr Ala Val Ala Val Ile Thr Val Gln Leu Arg 
    210                 215                 220                 


Arg Gln Tyr Val Arg Lys Tyr Glu Gly Glu Ala Glu Glu Arg Lys Lys 
225                 230                 235                 240 


Leu Arg Gln Glu Asn Gly Asn Val His Ala Ile Ala 
                245                 250         


<210>  9
<211>  1323
<212>  DNA
<213>  Homo sapiens

<400>  9
gcccgaatat gtccctgggt gtgggtatgg gtgtggggca atttgggtgg gagcagcgtg       60

gaggctccca ggaccaagtc ctgcgcctct ttggcggggt gtgtgcagga ggagggggga      120

taaataggag gctccctcct cccggcgaca ttcacggagc cggccggcct cccgccctgg      180

gtgtttccct gccttgtagc cagggtgcca gcctgggaag tagtttcgtt tccttctgcc      240

tccgggatta gtttccaggc accctctcag gcgcccgagg cccgggaagg gggcgaagaa      300

ggagggagac ttgtctaggg gctgcccggc ccggcagagc ggggttgatg gaccgggccg      360

cccggtgcag cggcgccagc tccctgccac tgctcctggc ccttgccctg ggtctagtga      420

tccttcactg tgtggtggca gatgggaatt ccaccagaag tcctgaaact aatggcctcc      480

tctgtggaga ccctgaggaa aactgtgcag ctaccaccac acaatcaaag cggaaaggcc      540

acttctctag gtgccccaag caatacaagc attactgcat caaagggaga tgccgcttcg      600

tggtggccga gcagacgccc tcctgtgtct gtgatgaagg ctacattgga gcaaggtgtg      660

agagagttga cttgttttac ctaagaggag acagaggaca gattctggtg atttgtttga      720

tagcagttat ggtagttttt attattttgg tcatcggtgt ctgcacatgc tgtcaccctc      780

ttcggaaacg tcgtaaaaga aagaagaaag aagaagaaat ggaaactctg ggtaaagata      840

taactcctat caatgaagat attgaagaga caaatattgc ttaaaaggct atgaagttac      900

ctccaggttg gtggcaagct gcaaagtgcc ttgctcattt gaaaatggac agaatgtgtc      960

tcaggaaaac agctagtaga catgaatttt aaataatgta tttacttttt atttgcaact     1020

ttagtttgtg ttattatttt ttaataagaa cattaattat atgtatattg tctagtaatt     1080

gggaaaaaag caactggtta ggtagcaaca acagaaggga aatttcaata acctttcact     1140

taagtattgt caccaggatt actagtcaaa caaaaaagaa aagtagaaag gaggttaggt     1200

cttaggaatt gaattaataa taaagctacc atttatcaag catttaccat gtgctaataa     1260

gtttgaaata tattatttcc tttattcctt tcagcaatcc atgagatagc tattataatc     1320

ctc                                                                   1323


<210>  10
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Asp Arg Ala Ala Arg Cys Ser Gly Ala Ser Ser Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Leu Ala Leu Gly Leu Val Ile Leu His Cys Val Val Ala Asp 
            20                  25                  30          


Gly Asn Ser Thr Arg Ser Pro Glu Thr Asn Gly Leu Leu Cys Gly Asp 
        35                  40                  45              


Pro Glu Glu Asn Cys Ala Ala Thr Thr Thr Gln Ser Lys Arg Lys Gly 
    50                  55                  60                  


His Phe Ser Arg Cys Pro Lys Gln Tyr Lys His Tyr Cys Ile Lys Gly 
65                  70                  75                  80  


Arg Cys Arg Phe Val Val Ala Glu Gln Thr Pro Ser Cys Val Cys Asp 
                85                  90                  95      


Glu Gly Tyr Ile Gly Ala Arg Cys Glu Arg Val Asp Leu Phe Tyr Leu 
            100                 105                 110         


Arg Gly Asp Arg Gly Gln Ile Leu Val Ile Cys Leu Ile Ala Val Met 
        115                 120                 125             


Val Val Phe Ile Ile Leu Val Ile Gly Val Cys Thr Cys Cys His Pro 
    130                 135                 140                 


Leu Arg Lys Arg Arg Lys Arg Lys Lys Lys Glu Glu Glu Met Glu Thr 
145                 150                 155                 160 


Leu Gly Lys Asp Ile Thr Pro Ile Asn Glu Asp Ile Glu Glu Thr Asn 
                165                 170                 175     


Ile Ala 
        


<210>  11
<211>  4628
<212>  DNA
<213>  Homo sapiens

<400>  11
tcacttgcct gatatttcca gtgtcagagg gacacagcca acgtggggtc ccttctaggc       60

tgacagccgc tctccagcca ctgccgcgag cccgtctgct cccgccctgc ccgtgcactc      120

tccgcagccg ccctccgcca agccccagcg cccgctccca tcgccgatga ccgcggggag      180

gaggatggag atgctctgtg ccggcagggt ccctgcgctg ctgctctgcc tgggtttcca      240

tcttctacag gcagtcctca gtacaactgt gattccatca tgtatcccag gagagtccag      300

tgataactgc acagctttag ttcagacaga agacaatcca cgtgtggctc aagtgtcaat      360

aacaaagtgt agctctgaca tgaatggcta ttgtttgcat ggacagtgca tctatctggt      420

ggacatgagt caaaactact gcaggtgtga agtgggttat actggtgtcc gatgtgaaca      480

cttcttttta accgtccacc aacctttaag caaagaatat gtggctttga ccgtgattct      540

tattattttg tttcttatca cagtcgtcgg ttccacatat tatttctgca gatggtacag      600

aaatcgaaaa agtaaagaac caaagaagga atatgagaga gttacctcag gggatccaga      660

gttgccgcaa gtctgaatgg cgccatcaaa cttatgggca gggataacag tgtgcctggt      720

taatattaat attcccattt tattaataat atttatgttg ggtcaagtgt taggtcaata      780

acactgtatt ttaatgtact tgaaaaatgt ttttattttt gttttatttt tgacagacta      840

tttgctaatg tataatgtgc agaaaatatt taatatcaaa agaaaattga tatttttata      900

caagtaattt cctgagctaa atgcttcatt gaaagcttca aagtttatat gcctggtgca      960

cagtgcttag aagtaagcaa ttcccaggtc atagctcaag aattgttagc aaatgacaga     1020

tttctgtaag cctatatata tagtcaaatc gatttagtaa gtatgttttt tatgttcctc     1080

aaatcagtga taattggttt gactgtacca tggtttgata tgtagttggc accatggtat     1140

catatattaa aacaataatg caattagaat ttgggagaag caaatatagg tcctgtgtta     1200

aacactacac atttgaaaca agctaaccct ggggagtcta tggtctcttc actcaggtct     1260

cagctataat tctgttatat gaggggcagt ggacagttcc ctatgccaac tcacgactcc     1320

tacaggtact agtcactcat ctaccagatt ctgcctatgt aaaatgaatt gaaaaacaat     1380

tttctgtaat cttttattta agtagtgggc atttcatagc ttcacaatgt tccttttttg     1440

tatattacaa catttatgtg aggtaattat tgctcaacag acaattagaa aaaagtccac     1500

acttgaagcc taaatttgtg ctttttaaga atatttttag actatttctt tttatagggg     1560

ctttgctgaa ttctaacatt aaatcacagc ccaaaatttg atggactaat tattatttta     1620

aaatatatga agacaataat tctacatgtt gtcttaagat ggaaatacag ttatttcatc     1680

ttttattcaa ggaagtttta actttaatac agctcagtaa atggcttctt ctagaatgta     1740

aagttatgta tttaaagttg tatcttgaca caggaaatgg gaaaaaactt aaaaattaat     1800

atggtgtatt tttccaaatg aaaaatctca attgaaagct tttaaaatgt agaaacttaa     1860

acacaccttc ctgtggaggc tgagatgaaa actagggctc attttcctga catttgttta     1920

ttttttggaa gagacaaaga tttcttctgc actctgagcc cataggtctc agagagttaa     1980

taggagtatt tttgggctat tgcataagga gccactgctg ccaccacttt tggattttat     2040

gggaggctcc ttcatcgaat gctaaacctt tgagtagagt ctccctggat cacataccag     2100

gtcagggagg atctgttctt cctctacgtt tatcctggca tgtgctaggg taaacgaagg     2160

cataataagc catggctgac ctctggagca ccaggtgcca ggacttgtct ccatgtgtat     2220

ccatgcatta tataccctgg tgcaatcaca cgactgtcat ctaaagtcct ggccctggcc     2280

cttactatta ggaaaataaa cagacaaaaa caagtaaata tatatggtca tatacatatt     2340

gtatatatat tcatatacaa acatgtatgt atacatgacc ttaatggatc atagaattgc     2400

agtcatttgg tgctctgcta accatttata taaaacttaa aaacaagaga aaagaaaaat     2460

caattagatc taaacagtta tttctgtttc ctatttaata cagctgaagt caaaatatgt     2520

aagaacacat tttaaatact ctacttacag ttggccctct gtggttagtt ccacatctgt     2580

ggattcaacc aaccaaggac ggaaaatgct taaaaaataa tacaacaaca acaaaaaata     2640

cattataaca actatttact tttttttttt tctttttgag atggagtctc gctctgttgc     2700

ccaggttgga gtgcagtggc acgatctcgg ctcactgcaa cctcacctcc cgggttcaag     2760

agatcctcct gcctcagcct cctgagcagc tgggactaca ggcgcatgcc accatgccca     2820

gctaattttt gtatttttag tagaggcggg gtttcaccat gttggccagg atggtctcaa     2880

tctcctaacc ttgagatcca ccctccacag cctcccaaac tgctgggatt acaggtgtga     2940

gccaccgcac gtagcattta cattaggtat tacaagtaat gtaaagatga tttaagtata     3000

caggaggatg tgaataggtt atatgcaagc actatgccct tttatataag tgacttgaac     3060

atctgtgccc gattttagta tgtgcagggg ggcgatctgg gaatcagtcc cctgtggata     3120

ccaaggtaca actgtattta ttaacgctta ctagatgtga ggagagtctg aatattttca     3180

gtgatcttgg ctgtttcaaa aaaatctatt gacttttcaa taaatcagct gcaatccatt     3240

tatttcattt acaaaagatt tattgtaagc atctcaatct tggtttgtca gtttatctta     3300

agcatgtcaa ttcataaaaa caagtcattt ttgtattttt catctttaag aatgcttaaa     3360

aaagctaatc cctaaaatag ttagatcttt gtaaatgcat attaaataat aaagtatgac     3420

ccacattact ttttatgggt gaaaataaga caaaaataat agttttagtg aggatggtgc     3480

tgagtaaaca taaaaactga tttgctctca gctgatgtgt cctgtacaca gtgggaagat     3540

tttagttcac acttagtcta actcccccat tttacagatt tctcactata tatatttcta     3600

gaaggggcta tgcatattca atgtattgag aaccaaagca accacaaatg cataaatgca     3660

taatttatgg tcttcaacca aggccacata ataacccagt taacttactc tttaaccagg     3720

aatattaagt tctataacta gtactcaagg tttaacctta aaattaagat ttccttaacc     3780

ttaaccttaa aattgatatt atattaaaca tacataatac aatgtaactc cactgttctc     3840

ctgaatattt tttgctctaa tctctctgcc gaaagtcaaa gtgatgggag aattggtata     3900

ctggtatgac tacgtcttaa gtcagatttt tatttatgag tctttgagac taaattcaat     3960

caccaccagg tatcaaatca acttttatgc agcaaatata tgattctagt gtctgacttt     4020

tgttaaattc agtaatgcag tttttaaaaa cctgtatctg acccactttg taatttttgc     4080

tccaatatcc attctgtaga cttttgaaaa aaaagttttt aatttgatgc ccaatatatt     4140

ctgaccgtta aaaaattctt gttcatatgg gagaaggggg agtaatgact tgtacaaaca     4200

gtatttctgg tgtatatttt aatgttttta aaaagagtaa tttcatttaa atatctgtta     4260

ttcaaatttg atgatgttaa atgtaatata atgtattttc tttttatttt gcactctgta     4320

attgcacttt ttaagtttga agagccattt tggtaaacgg tttttattaa agatgctatg     4380

gaacataaag ttgtattgca tgcaatttga agtaacttat ttgactatga atgttatcgg     4440

attactgaat tgtatcaatt tgtttgtgtt caatatcagc tttgataatt gtgtacctta     4500

agatattgaa ggagaaaata gataatttac aagatattat taatttttat ttatttttct     4560

tgggaattga aaaaaattga aataaataaa aatgcattga acatcttgca ttcaaaatct     4620

tcactgac                                                              4628


<210>  12
<211>  169
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Thr Ala Gly Arg Arg Met Glu Met Leu Cys Ala Gly Arg Val Pro 
1               5                   10                  15      


Ala Leu Leu Leu Cys Leu Gly Phe His Leu Leu Gln Ala Val Leu Ser 
            20                  25                  30          


Thr Thr Val Ile Pro Ser Cys Ile Pro Gly Glu Ser Ser Asp Asn Cys 
        35                  40                  45              


Thr Ala Leu Val Gln Thr Glu Asp Asn Pro Arg Val Ala Gln Val Ser 
    50                  55                  60                  


Ile Thr Lys Cys Ser Ser Asp Met Asn Gly Tyr Cys Leu His Gly Gln 
65                  70                  75                  80  


Cys Ile Tyr Leu Val Asp Met Ser Gln Asn Tyr Cys Arg Cys Glu Val 
                85                  90                  95      


Gly Tyr Thr Gly Val Arg Cys Glu His Phe Phe Leu Thr Val His Gln 
            100                 105                 110         


Pro Leu Ser Lys Glu Tyr Val Ala Leu Thr Val Ile Leu Ile Ile Leu 
        115                 120                 125             


Phe Leu Ile Thr Val Val Gly Ser Thr Tyr Tyr Phe Cys Arg Trp Tyr 
    130                 135                 140                 


Arg Asn Arg Lys Ser Lys Glu Pro Lys Lys Glu Tyr Glu Arg Val Thr 
145                 150                 155                 160 


Ser Gly Asp Pro Glu Leu Pro Gln Val 
                165                 


<210>  13
<211>  847
<212>  DNA
<213>  Homo sapiens

<400>  13
cgtcagtcta gaaggataag agaaagaaag ttaagcaact acaggaaatg gctttgggag       60

ttccaatatc agtctatctt ttattcaacg caatgacagc actgaccgaa gaggcagccg      120

tgactgtaac acctccaatc acagcccagc aagctgacaa catagaagga cccatagcct      180

tgaagttctc acacctttgc ctggaagatc ataacagtta ctgcatcaac ggtgcttgtg      240

cattccacca tgagctagag aaagccatct gcaggtgttt tactggttat actggagaaa      300

ggtgtgagca cttgacttta acttcatatg ctgtggattc ttatgaaaaa tacattgcaa      360

ttgggattgg tgttggatta ctattaagtg gttttcttgt tattttttac tgctatataa      420

gaaagaggta tgaaaaagac aaaatatgaa gtcacttcat atgcaatcgt ttgacaaata      480

gttattcagg ccctataatg tgtcaggcac tgacatgtaa aattttttta attaaaaaag      540

agctgtaatc tggcaaaaag tttctatgta atatttttca tgccttttct cataaaccca      600

gacgagtggt aaaaatttgc cttcagttgt aataggagag ttcaaacgta cagtctccct      660

tcaacctatc tctgtctgcc catatcaaaa ttataaatga ggaggacagc aggccccaag      720

aaagtaggga ctaagtatgt cttgttcaaa attgtatatt cagtgactta cactatgcct      780

agcacacaac acacactgag taaatatttg ttgagtgaaa taaaatcaag aaacaagtaa      840

aaactga                                                                847


<210>  14
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Leu Gly Val Pro Ile Ser Val Tyr Leu Leu Phe Asn Ala Met 
1               5                   10                  15      


Thr Ala Leu Thr Glu Glu Ala Ala Val Thr Val Thr Pro Pro Ile Thr 
            20                  25                  30          


Ala Gln Gln Ala Asp Asn Ile Glu Gly Pro Ile Ala Leu Lys Phe Ser 
        35                  40                  45              


His Leu Cys Leu Glu Asp His Asn Ser Tyr Cys Ile Asn Gly Ala Cys 
    50                  55                  60                  


Ala Phe His His Glu Leu Glu Lys Ala Ile Cys Arg Cys Phe Thr Gly 
65                  70                  75                  80  


Tyr Thr Gly Glu Arg Cys Glu His Leu Thr Leu Thr Ser Tyr Ala Val 
                85                  90                  95      


Asp Ser Tyr Glu Lys Tyr Ile Ala Ile Gly Ile Gly Val Gly Leu Leu 
            100                 105                 110         


Leu Ser Gly Phe Leu Val Ile Phe Tyr Cys Tyr Ile Arg Lys Arg Tyr 
        115                 120                 125             


Glu Lys Asp Lys Ile 
    130             


<210>  15
<211>  5616
<212>  DNA
<213>  Homo sapiens

<400>  15
ccccggcgca gcgcggccgc agcagcctcc gccccccgca cggtgtgagc gcccgacgcg       60

gccgaggcgg ccggagtccc gagctagccc cggcggccgc cgccgcccag accggacgac      120

aggccacctc gtcggcgtcc gcccgagtcc ccgcctcgcc gccaacgcca caaccaccgc      180

gcacggcccc ctgactccgt ccagtattga tcgggagagc cggagcgagc tcttcgggga      240

gcagcgatgc gaccctccgg gacggccggg gcagcgctcc tggcgctgct ggctgcgctc      300

tgcccggcga gtcgggctct ggaggaaaag aaagtttgcc aaggcacgag taacaagctc      360

acgcagttgg gcacttttga agatcatttt ctcagcctcc agaggatgtt caataactgt      420

gaggtggtcc ttgggaattt ggaaattacc tatgtgcaga ggaattatga tctttccttc      480

ttaaagacca tccaggaggt ggctggttat gtcctcattg ccctcaacac agtggagcga      540

attcctttgg aaaacctgca gatcatcaga ggaaatatgt actacgaaaa ttcctatgcc      600

ttagcagtct tatctaacta tgatgcaaat aaaaccggac tgaaggagct gcccatgaga      660

aatttacagg aaatcctgca tggcgccgtg cggttcagca acaaccctgc cctgtgcaac      720

gtggagagca tccagtggcg ggacatagtc agcagtgact ttctcagcaa catgtcgatg      780

gacttccaga accacctggg cagctgccaa aagtgtgatc caagctgtcc caatgggagc      840

tgctggggtg caggagagga gaactgccag aaactgacca aaatcatctg tgcccagcag      900

tgctccgggc gctgccgtgg caagtccccc agtgactgct gccacaacca gtgtgctgca      960

ggctgcacag gcccccggga gagcgactgc ctggtctgcc gcaaattccg agacgaagcc     1020

acgtgcaagg acacctgccc cccactcatg ctctacaacc ccaccacgta ccagatggat     1080

gtgaaccccg agggcaaata cagctttggt gccacctgcg tgaagaagtg tccccgtaat     1140

tatgtggtga cagatcacgg ctcgtgcgtc cgagcctgtg gggccgacag ctatgagatg     1200

gaggaagacg gcgtccgcaa gtgtaagaag tgcgaagggc cttgccgcaa agtgtgtaac     1260

ggaataggta ttggtgaatt taaagactca ctctccataa atgctacgaa tattaaacac     1320

ttcaaaaact gcacctccat cagtggcgat ctccacatcc tgccggtggc atttaggggt     1380

gactccttca cacatactcc tcctctggat ccacaggaac tggatattct gaaaaccgta     1440

aaggaaatca cagggttttt gctgattcag gcttggcctg aaaacaggac ggacctccat     1500

gcctttgaga acctagaaat catacgcggc aggaccaagc aacatggtca gttttctctt     1560

gcagtcgtca gcctgaacat aacatccttg ggattacgct ccctcaagga gataagtgat     1620

ggagatgtga taatttcagg aaacaaaaat ttgtgctatg caaatacaat aaactggaaa     1680

aaactgtttg ggacctccgg tcagaaaacc aaaattataa gcaacagagg tgaaaacagc     1740

tgcaaggcca caggccaggt ctgccatgcc ttgtgctccc ccgagggctg ctggggcccg     1800

gagcccaggg actgcgtctc ttgccggaat gtcagccgag gcagggaatg cgtggacaag     1860

tgcaaccttc tggagggtga gccaagggag tttgtggaga actctgagtg catacagtgc     1920

cacccagagt gcctgcctca ggccatgaac atcacctgca caggacgggg accagacaac     1980

tgtatccagt gtgcccacta cattgacggc ccccactgcg tcaagacctg cccggcagga     2040

gtcatgggag aaaacaacac cctggtctgg aagtacgcag acgccggcca tgtgtgccac     2100

ctgtgccatc caaactgcac ctacggatgc actgggccag gtcttgaagg ctgtccaacg     2160

aatgggccta agatcccgtc catcgccact gggatggtgg gggccctcct cttgctgctg     2220

gtggtggccc tggggatcgg cctcttcatg cgaaggcgcc acatcgttcg gaagcgcacg     2280

ctgcggaggc tgctgcagga gagggagctt gtggagcctc ttacacccag tggagaagct     2340

cccaaccaag ctctcttgag gatcttgaag gaaactgaat tcaaaaagat caaagtgctg     2400

ggctccggtg cgttcggcac ggtgtataag ggactctgga tcccagaagg tgagaaagtt     2460

aaaattcccg tcgctatcaa ggaattaaga gaagcaacat ctccgaaagc caacaaggaa     2520

atcctcgatg aagcctacgt gatggccagc gtggacaacc cccacgtgtg ccgcctgctg     2580

ggcatctgcc tcacctccac cgtgcagctc atcacgcagc tcatgccctt cggctgcctc     2640

ctggactatg tccgggaaca caaagacaat attggctccc agtacctgct caactggtgt     2700

gtgcagatcg caaagggcat gaactacttg gaggaccgtc gcttggtgca ccgcgacctg     2760

gcagccagga acgtactggt gaaaacaccg cagcatgtca agatcacaga ttttgggctg     2820

gccaaactgc tgggtgcgga agagaaagaa taccatgcag aaggaggcaa agtgcctatc     2880

aagtggatgg cattggaatc aattttacac agaatctata cccaccagag tgatgtctgg     2940

agctacgggg tgaccgtttg ggagttgatg acctttggat ccaagccata tgacggaatc     3000

cctgccagcg agatctcctc catcctggag aaaggagaac gcctccctca gccacccata     3060

tgtaccatcg atgtctacat gatcatggtc aagtgctgga tgatagacgc agatagtcgc     3120

ccaaagttcc gtgagttgat catcgaattc tccaaaatgg cccgagaccc ccagcgctac     3180

cttgtcattc agggggatga aagaatgcat ttgccaagtc ctacagactc caacttctac     3240

cgtgccctga tggatgaaga agacatggac gacgtggtgg atgccgacga gtacctcatc     3300

ccacagcagg gcttcttcag cagcccctcc acgtcacgga ctcccctcct gagctctctg     3360

agtgcaacca gcaacaattc caccgtggct tgcattgata gaaatgggct gcaaagctgt     3420

cccatcaagg aagacagctt cttgcagcga tacagctcag accccacagg cgccttgact     3480

gaggacagca tagacgacac cttcctccca gtgcctgaat acataaacca gtccgttccc     3540

aaaaggcccg ctggctctgt gcagaatcct gtctatcaca atcagcctct gaaccccgcg     3600

cccagcagag acccacacta ccaggacccc cacagcactg cagtgggcaa ccccgagtat     3660

ctcaacactg tccagcccac ctgtgtcaac agcacattcg acagccctgc ccactgggcc     3720

cagaaaggca gccaccaaat tagcctggac aaccctgact accagcagga cttctttccc     3780

aaggaagcca agccaaatgg catctttaag ggctccacag ctgaaaatgc agaataccta     3840

agggtcgcgc cacaaagcag tgaatttatt ggagcatgac cacggaggat agtatgagcc     3900

ctaaaaatcc agactctttc gatacccagg accaagccac agcaggtcct ccatcccaac     3960

agccatgccc gcattagctc ttagacccac agactggttt tgcaacgttt acaccgacta     4020

gccaggaagt acttccacct cgggcacatt ttgggaagtt gcattccttt gtcttcaaac     4080

tgtgaagcat ttacagaaac gcatccagca agaatattgt ccctttgagc agaaatttat     4140

ctttcaaaga ggtatatttg aaaaaaaaaa aaagtatatg tgaggatttt tattgattgg     4200

ggatcttgga gtttttcatt gtcgctattg atttttactt caatgggctc ttccaacaag     4260

gaagaagctt gctggtagca cttgctaccc tgagttcatc caggcccaac tgtgagcaag     4320

gagcacaagc cacaagtctt ccagaggatg cttgattcca gtggttctgc ttcaaggctt     4380

ccactgcaaa acactaaaga tccaagaagg ccttcatggc cccagcaggc cggatcggta     4440

ctgtatcaag tcatggcagg tacagtagga taagccactc tgtcccttcc tgggcaaaga     4500

agaaacggag gggatggaat tcttccttag acttactttt gtaaaaatgt ccccacggta     4560

cttactcccc actgatggac cagtggtttc cagtcatgag cgttagactg acttgtttgt     4620

cttccattcc attgttttga aactcagtat gctgcccctg tcttgctgtc atgaaatcag     4680

caagagagga tgacacatca aataataact cggattccag cccacattgg attcatcagc     4740

atttggacca atagcccaca gctgagaatg tggaatacct aaggatagca ccgcttttgt     4800

tctcgcaaaa acgtatctcc taatttgagg ctcagatgaa atgcatcagg tcctttgggg     4860

catagatcag aagactacaa aaatgaagct gctctgaaat ctcctttagc catcacccca     4920

accccccaaa attagtttgt gttacttatg gaagatagtt ttctcctttt acttcacttc     4980

aaaagctttt tactcaaaga gtatatgttc cctccaggtc agctgccccc aaaccccctc     5040

cttacgcttt gtcacacaaa aagtgtctct gccttgagtc atctattcaa gcacttacag     5100

ctctggccac aacagggcat tttacaggtg cgaatgacag tagcattatg agtagtgtgg     5160

aattcaggta gtaaatatga aactagggtt tgaaattgat aatgctttca caacatttgc     5220

agatgtttta gaaggaaaaa agttccttcc taaaataatt tctctacaat tggaagattg     5280

gaagattcag ctagttagga gcccaccttt tttcctaatc tgtgtgtgcc ctgtaacctg     5340

actggttaac agcagtcctt tgtaaacagt gttttaaact ctcctagtca atatccaccc     5400

catccaattt atcaaggaag aaatggttca gaaaatattt tcagcctaca gttatgttca     5460

gtcacacaca catacaaaat gttccttttg cttttaaagt aatttttgac tcccagatca     5520

gtcagagccc ctacagcatt gttaagaaag tatttgattt ttgtctcaat gaaaataaaa     5580

ctatattcat ttccactcta aaaaaaaaaa aaaaaa                               5616


<210>  16
<211>  1210
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala 
1               5                   10                  15      


Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln 
            20                  25                  30          


Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe 
        35                  40                  45              


Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn 
    50                  55                  60                  


Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys 
65                  70                  75                  80  


Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val 
                85                  90                  95      


Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr 
            100                 105                 110         


Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn 
        115                 120                 125             


Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu 
    130                 135                 140                 


His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu 
145                 150                 155                 160 


Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met 
                165                 170                 175     


Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro 
            180                 185                 190         


Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln 
        195                 200                 205             


Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg 
    210                 215                 220                 


Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys 
225                 230                 235                 240 


Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp 
                245                 250                 255     


Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro 
            260                 265                 270         


Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly 
        275                 280                 285             


Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His 
    290                 295                 300                 


Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu 
305                 310                 315                 320 


Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val 
                325                 330                 335     


Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn 
            340                 345                 350         


Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp 
        355                 360                 365             


Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr 
    370                 375                 380                 


Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu 
385                 390                 395                 400 


Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp 
                405                 410                 415     


Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln 
            420                 425                 430         


His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu 
        435                 440                 445             


Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser 
    450                 455                 460                 


Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu 
465                 470                 475                 480 


Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu 
                485                 490                 495     


Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro 
            500                 505                 510         


Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn 
        515                 520                 525             


Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly 
    530                 535                 540                 


Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro 
545                 550                 555                 560 


Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro 
                565                 570                 575     


Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val 
            580                 585                 590         


Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp 
        595                 600                 605             


Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys 
    610                 615                 620                 


Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly 
625                 630                 635                 640 


Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu 
                645                 650                 655     


Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His 
            660                 665                 670         


Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu 
        675                 680                 685             


Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu 
    690                 695                 700                 


Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser 
705                 710                 715                 720 


Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu 
                725                 730                 735     


Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser 
            740                 745                 750         


Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser 
        755                 760                 765             


Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser 
    770                 775                 780                 


Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp 
785                 790                 795                 800 


Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn 
                805                 810                 815     


Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg 
            820                 825                 830         


Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro 
        835                 840                 845             


Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala 
    850                 855                 860                 


Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp 
865                 870                 875                 880 


Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp 
                885                 890                 895     


Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser 
            900                 905                 910         


Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu 
        915                 920                 925             


Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr 
    930                 935                 940                 


Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys 
945                 950                 955                 960 


Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln 
                965                 970                 975     


Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro 
            980                 985                 990         


Thr Asp Ser Asn Phe Tyr Arg Ala  Leu Met Asp Glu Glu  Asp Met Asp 
        995                 1000                 1005             


Asp Val  Val Asp Ala Asp Glu  Tyr Leu Ile Pro Gln  Gln Gly Phe 
    1010                 1015                 1020             


Phe Ser  Ser Pro Ser Thr Ser  Arg Thr Pro Leu Leu  Ser Ser Leu 
    1025                 1030                 1035             


Ser Ala  Thr Ser Asn Asn Ser  Thr Val Ala Cys Ile  Asp Arg Asn 
    1040                 1045                 1050             


Gly Leu  Gln Ser Cys Pro Ile  Lys Glu Asp Ser Phe  Leu Gln Arg 
    1055                 1060                 1065             


Tyr Ser  Ser Asp Pro Thr Gly  Ala Leu Thr Glu Asp  Ser Ile Asp 
    1070                 1075                 1080             


Asp Thr  Phe Leu Pro Val Pro  Glu Tyr Ile Asn Gln  Ser Val Pro 
    1085                 1090                 1095             


Lys Arg  Pro Ala Gly Ser Val  Gln Asn Pro Val Tyr  His Asn Gln 
    1100                 1105                 1110             


Pro Leu  Asn Pro Ala Pro Ser  Arg Asp Pro His Tyr  Gln Asp Pro 
    1115                 1120                 1125             


His Ser  Thr Ala Val Gly Asn  Pro Glu Tyr Leu Asn  Thr Val Gln 
    1130                 1135                 1140             


Pro Thr  Cys Val Asn Ser Thr  Phe Asp Ser Pro Ala  His Trp Ala 
    1145                 1150                 1155             


Gln Lys  Gly Ser His Gln Ile  Ser Leu Asp Asn Pro  Asp Tyr Gln 
    1160                 1165                 1170             


Gln Asp  Phe Phe Pro Lys Glu  Ala Lys Pro Asn Gly  Ile Phe Lys 
    1175                 1180                 1185             


Gly Ser  Thr Ala Glu Asn Ala  Glu Tyr Leu Arg Val  Ala Pro Gln 
    1190                 1195                 1200             


Ser Ser  Glu Phe Ile Gly Ala  
    1205                 1210 


