                         SEQUENCE LISTING

<110>  Diehn, Maximilian
       Gentles, Andrew J
       Alizadeh, Arash A
       Bratman, Scott V
 
<120>  METHODS AND COMPOSITIONS FOR ASSESSING PATIENTS WITH NON-SMALL 
       CELL LUNG CANCER

<130>  STAN-1023WO

<150>  61/952,057
<151>  2014-03-12

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  2470
<212>  DNA
<213>  Homo sapiens

<400>  1
ctctggctcc cagccccgca gcggccgagc tgcagcccgg gctcagtctc cgccgccgcc       60

gtgaacatgg agcccccgga cgcaccggcc caggcgcgcg gggccccgcg gctgctgttg      120

ctcgcagtcc tgctggcggc gcacccagat gcccaggcgg aggtgcgctt gtctgtaccc      180

ccgctggtgg aggtgatgcg aggaaagtct gtcattctgg actgcacccc tacgggaacc      240

cacgaccatt atatgctgga atggttcctt accgaccgct cgggagctcg cccccgccta      300

gcctcggctg agatgcaggg ctctgagctc caggtcacaa tgcacgacac ccggggccgc      360

agtcccccat accagctgga ctcccagggg cgcctggtgc tggctgaggc ccaggtgggc      420

gacgagcgag actacgtgtg cgtggtgagg gcaggggcgg caggcactgc tgaggccact      480

gcgcggctca acgtgtttgc aaagccagag gccactgagg tctcccccaa caaagggaca      540

ctgtctgtga tggaggactc tgcccaggag atcgccacct gcaacagccg gaacgggaac      600

ccggccccca agatcacgtg gtatcgcaac gggcagcgcc tggaggtgcc cgtagagatg      660

aacccagagg gctacatgac cagccgcacg gtccgggagg cctcgggcct gctctccctc      720

accagcaccc tctacctgcg gctccgcaag gatgaccgag acgccagctt ccactgcgcc      780

gcccactaca gcctgcccga gggccgccac ggccgcctgg acagccccac cttccacctc      840

accctgcact atcccacgga gcacgtgcag ttctgggtgg gcagcccgtc caccccagca      900

ggctgggtac gcgagggtga cactgtccag ctgctctgcc ggggggacgg cagccccagc      960

ccggagtata cgcttttccg ccttcaggat gagcaggagg aagtgctgaa tgtgaatctc     1020

gaggggaact tgaccctgga gggagtgacc cggggccaga gcgggaccta tggctgcaga     1080

gtggaggatt acgacgcggc agatgacgtg cagctctcca agacgctgga gctgcgcgtg     1140

gcctatctgg accccctgga gctcagcgag gggaaggtgc tttccttacc tctaaacagc     1200

agtgcagtcg tgaactgctc cgtgcacggc ctgcccaccc ctgccctacg ctggaccaag     1260

gactccactc ccctgggcga tggccccatg ctgtcgctca gttctatcac cttcgattcc     1320

aatggcacct acgtatgtga ggcctccctg cccacagtcc cggtcctcag ccgcacccag     1380

aacttcacgc tgctggtcca aggctcgcca gagctaaaga cagcggaaat agagcccaag     1440

gcagatggca gctggaggga aggagacgaa gtcacactca tctgctctgc ccgcggccat     1500

ccagacccca aactcagctg gagccaattg gggggcagcc ccgcagagcc aatccccgga     1560

cggcagggtt gggtgagcag ctctctgacc ctgaaagtga ccagcgccct gagccgcgat     1620

ggcatctcct gtgaagcctc caacccccac gggaacaagc gccatgtctt ccacttcggc     1680

accgtgagcc cccagacctc ccaggctgga gtggccgtca tggccgtggc cgtcagcgtg     1740

ggcctcctgc tcctcgtcgt tgctgtcttc tactgcgtga gacgcaaagg gggcccctgc     1800

tgccgccagc ggcgggagaa gggggctccg ccgccagggg agccagggct gagccactcg     1860

gggtcggagc aaccagagca gaccggcctt ctcatgggag gtgcctccgg aggagccagg     1920

ggtggcagcg ggggcttcgg agacgagtgc tgagccaaga acctcctaga ggctgtccct     1980

ggacctggag ctgcaggcat cagagaacca gccctgctca cgccatgccc gcccccgcct     2040

tccctcttcc ctcttccctc tccctgccca gccctccctt ccttcctctg ccggcaaggc     2100

agggacccac agtggctgcc tgcctccggg agggaaggag agggagggtg ggtgggtggg     2160

agggggcctt cctccaggga atgtgactct cccaggcccc agaatagctc ctggacccaa     2220

gcccaaggcc cagcctggga caaggctccg agggtcggct ggccggagct atttttacct     2280

cccgcctccc ctgctggtcc ccccacctga cgtcttgctg cagagtctga cactggattc     2340

ccccccctca ccccgcccct ggtcccactc ctgcccccgc cctacctccg ccccacccca     2400

tcatctgtgg acactggagt ctggaataaa tgctgtttgt cacatcaaca ccaaaaaaaa     2460

aaaaaaaaaa                                                            2470


<210>  2
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 
            20                  25                  30          


Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser 
        35                  40                  45              


Val Ile Leu Asp Cys Thr Pro Thr Gly Thr His Asp His Tyr Met Leu 
    50                  55                  60                  


Glu Trp Phe Leu Thr Asp Arg Ser Gly Ala Arg Pro Arg Leu Ala Ser 
65                  70                  75                  80  


Ala Glu Met Gln Gly Ser Glu Leu Gln Val Thr Met His Asp Thr Arg 
                85                  90                  95      


Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu 
            100                 105                 110         


Ala Glu Ala Gln Val Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg 
        115                 120                 125             


Ala Gly Ala Ala Gly Thr Ala Glu Ala Thr Ala Arg Leu Asn Val Phe 
    130                 135                 140                 


Ala Lys Pro Glu Ala Thr Glu Val Ser Pro Asn Lys Gly Thr Leu Ser 
145                 150                 155                 160 


Val Met Glu Asp Ser Ala Gln Glu Ile Ala Thr Cys Asn Ser Arg Asn 
                165                 170                 175     


Gly Asn Pro Ala Pro Lys Ile Thr Trp Tyr Arg Asn Gly Gln Arg Leu 
            180                 185                 190         


Glu Val Pro Val Glu Met Asn Pro Glu Gly Tyr Met Thr Ser Arg Thr 
        195                 200                 205             


Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Thr Ser Thr Leu Tyr Leu 
    210                 215                 220                 


Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser Phe His Cys Ala Ala His 
225                 230                 235                 240 


Tyr Ser Leu Pro Glu Gly Arg His Gly Arg Leu Asp Ser Pro Thr Phe 
                245                 250                 255     


His Leu Thr Leu His Tyr Pro Thr Glu His Val Gln Phe Trp Val Gly 
            260                 265                 270         


Ser Pro Ser Thr Pro Ala Gly Trp Val Arg Glu Gly Asp Thr Val Gln 
        275                 280                 285             


Leu Leu Cys Arg Gly Asp Gly Ser Pro Ser Pro Glu Tyr Thr Leu Phe 
    290                 295                 300                 


Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly 
305                 310                 315                 320 


Asn Leu Thr Leu Glu Gly Val Thr Arg Gly Gln Ser Gly Thr Tyr Gly 
                325                 330                 335     


Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp Asp Val Gln Leu Ser Lys 
            340                 345                 350         


Thr Leu Glu Leu Arg Val Ala Tyr Leu Asp Pro Leu Glu Leu Ser Glu 
        355                 360                 365             


Gly Lys Val Leu Ser Leu Pro Leu Asn Ser Ser Ala Val Val Asn Cys 
    370                 375                 380                 


Ser Val His Gly Leu Pro Thr Pro Ala Leu Arg Trp Thr Lys Asp Ser 
385                 390                 395                 400 


Thr Pro Leu Gly Asp Gly Pro Met Leu Ser Leu Ser Ser Ile Thr Phe 
                405                 410                 415     


Asp Ser Asn Gly Thr Tyr Val Cys Glu Ala Ser Leu Pro Thr Val Pro 
            420                 425                 430         


Val Leu Ser Arg Thr Gln Asn Phe Thr Leu Leu Val Gln Gly Ser Pro 
        435                 440                 445             


Glu Leu Lys Thr Ala Glu Ile Glu Pro Lys Ala Asp Gly Ser Trp Arg 
    450                 455                 460                 


Glu Gly Asp Glu Val Thr Leu Ile Cys Ser Ala Arg Gly His Pro Asp 
465                 470                 475                 480 


Pro Lys Leu Ser Trp Ser Gln Leu Gly Gly Ser Pro Ala Glu Pro Ile 
                485                 490                 495     


Pro Gly Arg Gln Gly Trp Val Ser Ser Ser Leu Thr Leu Lys Val Thr 
            500                 505                 510         


Ser Ala Leu Ser Arg Asp Gly Ile Ser Cys Glu Ala Ser Asn Pro His 
        515                 520                 525             


Gly Asn Lys Arg His Val Phe His Phe Gly Thr Val Ser Pro Gln Thr 
    530                 535                 540                 


Ser Gln Ala Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly Leu 
545                 550                 555                 560 


Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg Arg Lys Gly Gly 
                565                 570                 575     


Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly Ala Pro Pro Pro Gly Glu 
            580                 585                 590         


Pro Gly Leu Ser His Ser Gly Ser Glu Gln Pro Glu Gln Thr Gly Leu 
        595                 600                 605             


Leu Met Gly Gly Ala Ser Gly Gly Ala Arg Gly Gly Ser Gly Gly Phe 
    610                 615                 620                 


Gly Asp Glu Cys 
625             


<210>  3
<211>  3448
<212>  DNA
<213>  Homo sapiens

<400>  3
ctctggctcc cagccccgca gcggccgagc tgcagcccgg gctcagtctc cgccgccgcc       60

gtgaacatgg agcccccgga cgcaccggcc caggcgcgcg gggccccgcg gctgctgttg      120

ctcgcagtcc tgctggcggc gcacccagat gcccaggcgg aggtgcgctt gtctgtaccc      180

ccgctggtgg aggtgatgcg aggaaagtct gtcattctgg actgcacccc tacgggaacc      240

cacgaccatt atatgctgga atggttcctt accgaccgct cgggagctcg cccccgccta      300

gcctcggctg agatgcaggg ctctgagctc caggtcacaa tgcacgacac ccggggccgc      360

agtcccccat accagctgga ctcccagggg cgcctggtgc tggctgaggc ccaggtgggc      420

gacgagcgag actacgtgtg cgtggtgagg gcaggggcgg caggcactgc tgaggccact      480

gcgcggctca acgtgtttgc aaagccagag gccactgagg tctcccccaa caaagggaca      540

ctgtctgtga tggaggactc tgcccaggag atcgccacct gcaacagccg gaacgggaac      600

ccggccccca agatcacgtg gtatcgcaac gggcagcgcc tggaggtgcc cgtagagatg      660

aacccagagg gctacatgac cagccgcacg gtccgggagg cctcgggcct gctctccctc      720

accagcaccc tctacctgcg gctccgcaag gatgaccgag acgccagctt ccactgcgcc      780

gcccactaca gcctgcccga gggccgccac ggccgcctgg acagccccac cttccacctc      840

accctgcact atcccacgga gcacgtgcag ttctgggtgg gcagcccgtc caccccagca      900

ggctgggtac gcgagggtga cactgtccag ctgctctgcc ggggggacgg cagccccagc      960

ccggagtata cgcttttccg ccttcaggat gagcaggagg aagtgctgaa tgtgaatctc     1020

gaggggaact tgaccctgga gggagtgacc cggggccaga gcgggaccta tggctgcaga     1080

gtggaggatt acgacgcggc agatgacgtg cagctctcca agacgctgga gctgcgcgtg     1140

gcctatctgg accccctgga gctcagcgag gggaaggtgc tttccttacc tctaaacagc     1200

agtgcagtcg tgaactgctc cgtgcacggc ctgcccaccc ctgccctacg ctggaccaag     1260

gactccactc ccctgggcga tggccccatg ctgtcgctca gttctatcac cttcgattcc     1320

aatggcacct acgtatgtga ggcctccctg cccacagtcc cggtcctcag ccgcacccag     1380

aacttcacgc tgctggtcca aggctcgcca gagctaaaga cagcggaaat agagcccaag     1440

gcagatggca gctggaggga aggagacgaa gtcacactca tctgctctgc ccgcggccat     1500

ccagacccca aactcagctg gagccaattg gggggcagcc ccgcagagcc aatccccgga     1560

cggcagggtt gggtgagcag ctctctgacc ctgaaagtga ccagcgccct gagccgcgat     1620

ggcatctcct gtgaagcctc caacccccac gggaacaagc gccatgtctt ccacttcggc     1680

accgtgagcc cccagacctc ccaggctgga gtggccgtca tggccgtggc cgtcagcgtg     1740

ggcctcctgc tcctcgtcgt tgctgtcttc tactgcgtga gacgcaaagg gggcccctgc     1800

tgccgccagc ggcgggagaa gggggctccg tgagtggcct gctatctgca atgaccacca     1860

tagcttaacc ccatccccac cctcaacccc aagctcaacc cataacctca accacatctt     1920

atcctccacc ccacatccca ccacatccac ctccatcccc aacccatcct catccccaac     1980

tacagcccca aacccagccc cagactaatc cacagccatc cccaactcat cctcatcccc     2040

aactgcagcc ccaaacccaa cccagggcca tccccaaacc catccccaag ccaaactcaa     2100

caccatcccc ttccctaatc acctctcctg cccctagctc agcctcatcc ccaactccat     2160

gcctgtctcc aatcccaacc ctgcccccaa tctcccctca actccaatcc ataaccccct     2220

tcaaaccatc ctcaactaag ctcctctcca gccctggcca catccccatc ctcccccaac     2280

ctccagcccc aacacccatc atccccctga gctcaccctt aactccaatt tatcctccaa     2340

gcctatctct caccatccag ccctcaccta gccatttccc aaccctagtc ctccaccgtc     2400

ccgaagccaa cttcacccat gtccccatcc ccaatcttgt ccccattcct gactccaaat     2460

ccaaccccta agcctcccca agctcctcct catctaacct tgtctccagc cccaaccaca     2520

tggccgtcct cacctccaat ccgtaaccat cccagaccga tcccaaagcc aactccagct     2580

acattcccac ctccaacccc aatagcatct gcatccccat gcccaaccct aaccccagtg     2640

ccattaccag cccctacccc atccctatgc catccccacc cagcacaccc ccatcctcac     2700

ctccatcccc agccgcatcc tagtcccacc cacccccatc ctcagttcct ccccctgccg     2760

tgtgcacctc caacacgacg cctccgcccg ctgcctcctc cccccaggcc gccaggggag     2820

ccagggctga gccactcggg gtcggagcaa ccagagcaga ccggccttct catgggaggt     2880

gcctccggag gagccagggg tggcagcggg ggcttcggag acgagtgctg agccaagaac     2940

ctcctagagg ctgtccctgg acctggagct gcaggcatca gagaaccagc cctgctcacg     3000

ccatgcccgc ccccgccttc cctcttccct cttccctctc cctgcccagc cctcccttcc     3060

ttcctctgcc ggcaaggcag ggacccacag tggctgcctg cctccgggag ggaaggagag     3120

ggagggtggg tgggtgggag ggggccttcc tccagggaat gtgactctcc caggccccag     3180

aatagctcct ggacccaagc ccaaggccca gcctgggaca aggctccgag ggtcggctgg     3240

ccggagctat ttttacctcc cgcctcccct gctggtcccc ccacctgacg tcttgctgca     3300

gagtctgaca ctggattccc ccccctcacc ccgcccctgg tcccactcct gcccccgccc     3360

tacctccgcc ccaccccatc atctgtggac actggagtct ggaataaatg ctgtttgtca     3420

catcaacacc aaaaaaaaaa aaaaaaaa                                        3448


<210>  4
<211>  588
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Pro Pro Asp Ala Pro Ala Gln Ala Arg Gly Ala Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ala Val Leu Leu Ala Ala His Pro Asp Ala Gln Ala Glu 
            20                  25                  30          


Val Arg Leu Ser Val Pro Pro Leu Val Glu Val Met Arg Gly Lys Ser 
        35                  40                  45              


Val Ile Leu Asp Cys Thr Pro Thr Gly Thr His Asp His Tyr Met Leu 
    50                  55                  60                  


Glu Trp Phe Leu Thr Asp Arg Ser Gly Ala Arg Pro Arg Leu Ala Ser 
65                  70                  75                  80  


Ala Glu Met Gln Gly Ser Glu Leu Gln Val Thr Met His Asp Thr Arg 
                85                  90                  95      


Gly Arg Ser Pro Pro Tyr Gln Leu Asp Ser Gln Gly Arg Leu Val Leu 
            100                 105                 110         


Ala Glu Ala Gln Val Gly Asp Glu Arg Asp Tyr Val Cys Val Val Arg 
        115                 120                 125             


Ala Gly Ala Ala Gly Thr Ala Glu Ala Thr Ala Arg Leu Asn Val Phe 
    130                 135                 140                 


Ala Lys Pro Glu Ala Thr Glu Val Ser Pro Asn Lys Gly Thr Leu Ser 
145                 150                 155                 160 


Val Met Glu Asp Ser Ala Gln Glu Ile Ala Thr Cys Asn Ser Arg Asn 
                165                 170                 175     


Gly Asn Pro Ala Pro Lys Ile Thr Trp Tyr Arg Asn Gly Gln Arg Leu 
            180                 185                 190         


Glu Val Pro Val Glu Met Asn Pro Glu Gly Tyr Met Thr Ser Arg Thr 
        195                 200                 205             


Val Arg Glu Ala Ser Gly Leu Leu Ser Leu Thr Ser Thr Leu Tyr Leu 
    210                 215                 220                 


Arg Leu Arg Lys Asp Asp Arg Asp Ala Ser Phe His Cys Ala Ala His 
225                 230                 235                 240 


Tyr Ser Leu Pro Glu Gly Arg His Gly Arg Leu Asp Ser Pro Thr Phe 
                245                 250                 255     


His Leu Thr Leu His Tyr Pro Thr Glu His Val Gln Phe Trp Val Gly 
            260                 265                 270         


Ser Pro Ser Thr Pro Ala Gly Trp Val Arg Glu Gly Asp Thr Val Gln 
        275                 280                 285             


Leu Leu Cys Arg Gly Asp Gly Ser Pro Ser Pro Glu Tyr Thr Leu Phe 
    290                 295                 300                 


Arg Leu Gln Asp Glu Gln Glu Glu Val Leu Asn Val Asn Leu Glu Gly 
305                 310                 315                 320 


Asn Leu Thr Leu Glu Gly Val Thr Arg Gly Gln Ser Gly Thr Tyr Gly 
                325                 330                 335     


Cys Arg Val Glu Asp Tyr Asp Ala Ala Asp Asp Val Gln Leu Ser Lys 
            340                 345                 350         


Thr Leu Glu Leu Arg Val Ala Tyr Leu Asp Pro Leu Glu Leu Ser Glu 
        355                 360                 365             


Gly Lys Val Leu Ser Leu Pro Leu Asn Ser Ser Ala Val Val Asn Cys 
    370                 375                 380                 


Ser Val His Gly Leu Pro Thr Pro Ala Leu Arg Trp Thr Lys Asp Ser 
385                 390                 395                 400 


Thr Pro Leu Gly Asp Gly Pro Met Leu Ser Leu Ser Ser Ile Thr Phe 
                405                 410                 415     


Asp Ser Asn Gly Thr Tyr Val Cys Glu Ala Ser Leu Pro Thr Val Pro 
            420                 425                 430         


Val Leu Ser Arg Thr Gln Asn Phe Thr Leu Leu Val Gln Gly Ser Pro 
        435                 440                 445             


Glu Leu Lys Thr Ala Glu Ile Glu Pro Lys Ala Asp Gly Ser Trp Arg 
    450                 455                 460                 


Glu Gly Asp Glu Val Thr Leu Ile Cys Ser Ala Arg Gly His Pro Asp 
465                 470                 475                 480 


Pro Lys Leu Ser Trp Ser Gln Leu Gly Gly Ser Pro Ala Glu Pro Ile 
                485                 490                 495     


Pro Gly Arg Gln Gly Trp Val Ser Ser Ser Leu Thr Leu Lys Val Thr 
            500                 505                 510         


Ser Ala Leu Ser Arg Asp Gly Ile Ser Cys Glu Ala Ser Asn Pro His 
        515                 520                 525             


Gly Asn Lys Arg His Val Phe His Phe Gly Thr Val Ser Pro Gln Thr 
    530                 535                 540                 


Ser Gln Ala Gly Val Ala Val Met Ala Val Ala Val Ser Val Gly Leu 
545                 550                 555                 560 


Leu Leu Leu Val Val Ala Val Phe Tyr Cys Val Arg Arg Lys Gly Gly 
                565                 570                 575     


Pro Cys Cys Arg Gln Arg Arg Glu Lys Gly Ala Pro 
            580                 585             


<210>  5
<211>  3109
<212>  DNA
<213>  Homo sapiens

<400>  5
agcctgagaa tagttagcaa acaagggagg ttgtcatttc ctcatcgtca agctttgttc       60

ctcgtggggg ctagaaatct ctttccagtt ccagattgtg aagggttcct gagtaagcag      120

cgtgtctcca tccccctctc taggggctct tggatggacc ttgcactcta gaagggacaa      180

tggacttctg gctttggcca ctttacttcc tgccagtatc gggggccctg aggatcctcc      240

cagaagtaaa ggtagagggg gagctgggcg gatcagttac catcaagtgc ccacttcctg      300

aaatgcatgt gaggatatat ctgtgccggg agatggctgg atctggaaca tgtggtaccg      360

tggtatccac caccaacttc atcaaggcag aatacaaggg ccgagttact ctgaagcaat      420

acccacgcaa gaatctgttc ctagtggagg taacacagct gacagaaagt gacagcggag      480

tctatgcctg cggagcgggc atgaacacag accggggaaa gacccagaaa gtcaccctga      540

atgtccacag tgaatacgag ccatcatggg aagagcagcc aatgcctgag actccaaaat      600

ggtttcatct gccctatttg ttccagatgc ctgcatatgc cagttcttcc aaattcgtaa      660

ccagagttac cacaccagct caaaggggca aggtccctcc agttcaccac tcctccccca      720

ccacccaaat cacccaccgc cctcgagtgt ccagagcatc ttcagtagca ggtgacaagc      780

cccgaacctt cctgccatcc actacagcct caaaaatctc agctctggag gggctgctca      840

agccccagac gcccagctac aaccaccaca ccaggctgca caggcagaga gcactggact      900

atggctcaca gtctgggagg gaaggccaag gatttcacat cctgatcccg accatcctgg      960

gccttttcct gctggcactt ctggggctgg tggtgaaaag ggccgttgaa aggaggaaag     1020

ccctctccag gcgggcccgc cgactggccg tgaggatgcg cgccctggag agctcccaga     1080

ggccccgcgg gtcgccgcga ccgcgctccc aaaacaacat ctacagcgcc tgcccgcggc     1140

gcgctcgtgg agcggacgct gcaggcacag gggaggcccc cgttcccggc cccggagcgc     1200

cgttgccccc cgccccgctg caggtgtctg aatctccctg gctccatgcc ccatctctga     1260

agaccagctg tgaatacgtg agcctctacc accagcctgc cgccatgatg gaggacagtg     1320

attcagatga ctacatcaat gttcctgcct gacaactccc cagctatccc ccaaccccag     1380

gctcggactg tggtgccaag gagtctcatc tatctgctga tgtccaatac ctgcttcatg     1440

tgttctcaga gccctcatca cttcccatgc cccatctcga ctcccatccc catctatctg     1500

tgccctgagc atggctctgc ccccaggtcg tcttgcacac cttggcagcc ccctgtagtt     1560

gacaggtaag ctgtaggcat gtagagcaat tgtcccaatg ccacttgctt cctttccaag     1620

ccgtcgaaca gactgtggga tttgcagagt gtttcttcca tgtctttgac cacagggttg     1680

ttgctgccca ggctctagat cacatggcat caggctgggg cagaggcata gctattgtct     1740

cgggcatcct tcccagggtt gggtcttaca caaatagaag gctcttgctc tgagttatgt     1800

gacatgcctc agccccatgg actaagcagg ggtctggtat aaaaacactc ctggaaacgc     1860

ctttgccctg atccaaatgt tagcacttgc tagtgaacgt ctacttatct caagttctat     1920

gctaaaggca atttatcttg atgtgatgat aaaccaaact tattagcaag atatgcatat     1980

atatccataa attctcttta ctctgtctcc atcacttgat gcacataagt gccctgacct     2040

cagcatctcc cctctaaaaa aaaaaaaaaa aaagtatctc tttatctttc ttccatagcc     2100

tgacactgat atttgtgcac ttaccttaac tttggtctat tttattcatc caaaaccatt     2160

acatttcttg gttttcacaa atgttcccca tttcttagcc agttccagac aatgtatagc     2220

aagcagggga aggaaagcag tcaggagttc ctgggtggcc acggctctgc aatagcactt     2280

atgtcatgga agtgatatcc cacctcctac atatactctt tgcctaggtt tttggaacaa     2340

ggttatagtc agacactgta tctttagatt gatgtcgacc acaaagttca gccagagctt     2400

gaggctagat gcacagcctt gctattggga agaaggcctt ttctagctgt acaacacagt     2460

ctcactgggc attcatccag aaatagagaa gaaagtctgc cagacttgag ttatgttgtc     2520

ttttattagc agggaatgtc atcacagatt ggatagtaca tccaggtgca atgtcaccat     2580

cagcaaggtc agcttgacac tcaagtggaa gattagggaa gaatgactag gataaaaaaa     2640

aaaggagggc accaagggaa agggatgatg gggtgagctg gcgagtgtgg gtgggaaatg     2700

aaatgtttat tgaggatctg ctttgtgctg ggcactttaa tccacatttt atcgtttact     2760

tttcaaacag atgcacctta cccccacccc aatgctctgt ccctgcagat atcagaagac     2820

agtgtgattt tcatgctctg aagttcagtt ttacatccaa gcatccctct ctgtttttta     2880

acaatccaaa gacaggccaa aaaaagcacc acagtttatt aagtacttac taagcaccca     2940

tccactgccc cacactgtgg caaggattgt gaggggtaaa gaagcatggg gcacaatatt     3000

ctgctgcctt catgtaactt acagtctcac aaataaatag aacttcagtt gaaatactga     3060

cattaattaa atagagttgt aataaaaaaa aaaaaaaaaa aaaaaaaaa                 3109


<210>  6
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Phe Trp Leu Trp Pro Leu Tyr Phe Leu Pro Val Ser Gly Ala 
1               5                   10                  15      


Leu Arg Ile Leu Pro Glu Val Lys Val Glu Gly Glu Leu Gly Gly Ser 
            20                  25                  30          


Val Thr Ile Lys Cys Pro Leu Pro Glu Met His Val Arg Ile Tyr Leu 
        35                  40                  45              


Cys Arg Glu Met Ala Gly Ser Gly Thr Cys Gly Thr Val Val Ser Thr 
    50                  55                  60                  


Thr Asn Phe Ile Lys Ala Glu Tyr Lys Gly Arg Val Thr Leu Lys Gln 
65                  70                  75                  80  


Tyr Pro Arg Lys Asn Leu Phe Leu Val Glu Val Thr Gln Leu Thr Glu 
                85                  90                  95      


Ser Asp Ser Gly Val Tyr Ala Cys Gly Ala Gly Met Asn Thr Asp Arg 
            100                 105                 110         


Gly Lys Thr Gln Lys Val Thr Leu Asn Val His Ser Glu Tyr Glu Pro 
        115                 120                 125             


Ser Trp Glu Glu Gln Pro Met Pro Glu Thr Pro Lys Trp Phe His Leu 
    130                 135                 140                 


Pro Tyr Leu Phe Gln Met Pro Ala Tyr Ala Ser Ser Ser Lys Phe Val 
145                 150                 155                 160 


Thr Arg Val Thr Thr Pro Ala Gln Arg Gly Lys Val Pro Pro Val His 
                165                 170                 175     


His Ser Ser Pro Thr Thr Gln Ile Thr His Arg Pro Arg Val Ser Arg 
            180                 185                 190         


Ala Ser Ser Val Ala Gly Asp Lys Pro Arg Thr Phe Leu Pro Ser Thr 
        195                 200                 205             


Thr Ala Ser Lys Ile Ser Ala Leu Glu Gly Leu Leu Lys Pro Gln Thr 
    210                 215                 220                 


Pro Ser Tyr Asn His His Thr Arg Leu His Arg Gln Arg Ala Leu Asp 
225                 230                 235                 240 


Tyr Gly Ser Gln Ser Gly Arg Glu Gly Gln Gly Phe His Ile Leu Ile 
                245                 250                 255     


Pro Thr Ile Leu Gly Leu Phe Leu Leu Ala Leu Leu Gly Leu Val Val 
            260                 265                 270         


Lys Arg Ala Val Glu Arg Arg Lys Ala Leu Ser Arg Arg Ala Arg Arg 
        275                 280                 285             


Leu Ala Val Arg Met Arg Ala Leu Glu Ser Ser Gln Arg Pro Arg Gly 
    290                 295                 300                 


Ser Pro Arg Pro Arg Ser Gln Asn Asn Ile Tyr Ser Ala Cys Pro Arg 
305                 310                 315                 320 


Arg Ala Arg Gly Ala Asp Ala Ala Gly Thr Gly Glu Ala Pro Val Pro 
                325                 330                 335     


Gly Pro Gly Ala Pro Leu Pro Pro Ala Pro Leu Gln Val Ser Glu Ser 
            340                 345                 350         


Pro Trp Leu His Ala Pro Ser Leu Lys Thr Ser Cys Glu Tyr Val Ser 
        355                 360                 365             


Leu Tyr His Gln Pro Ala Ala Met Met Glu Asp Ser Asp Ser Asp Asp 
    370                 375                 380                 


Tyr Ile Asn Val Pro Ala 
385                 390 


<210>  7
<211>  2773
<212>  DNA
<213>  Homo sapiens

<400>  7
agcctgagaa tagttagcaa acaagggagg ttgtcatttc ctcatcgtca agctttgttc       60

ctcgtggggg ctagaaatct ctttccagtt ccagattgtg aagggttcct gagtaagcag      120

cgtgtctcca tccccctctc taggggctct tggatggacc ttgcactcta gaagggacaa      180

tggacttctg gctttggcca ctttacttcc tgccagaata cgagccatca tgggaagagc      240

agccaatgcc tgagactcca aaatggtttc atctgcccta tttgttccag atgcctgcat      300

atgccagttc ttccaaattc gtaaccagag ttaccacacc agctcaaagg ggcaaggtcc      360

ctccagttca ccactcctcc cccaccaccc aaatcaccca ccgccctcga gtgtccagag      420

catcttcagt agcaggtgac aagccccgaa ccttcctgcc atccactaca gcctcaaaaa      480

tctcagctct ggaggggctg ctcaagcccc agacgcccag ctacaaccac cacaccaggc      540

tgcacaggca gagagcactg gactatggct cacagtctgg gagggaaggc caaggatttc      600

acatcctgat cccgaccatc ctgggccttt tcctgctggc acttctgggg ctggtggtga      660

aaagggccgt tgaaaggagg aaagccctct ccaggcgggc ccgccgactg gccgtgagga      720

tgcgcgccct ggagagctcc cagaggcccc gcgggtcgcc gcgaccgcgc tcccaaaaca      780

acatctacag cgcctgcccg cggcgcgctc gtggagcgga cgctgcaggc acaggggagg      840

cccccgttcc cggccccgga gcgccgttgc cccccgcccc gctgcaggtg tctgaatctc      900

cctggctcca tgccccatct ctgaagacca gctgtgaata cgtgagcctc taccaccagc      960

ctgccgccat gatggaggac agtgattcag atgactacat caatgttcct gcctgacaac     1020

tccccagcta tcccccaacc ccaggctcgg actgtggtgc caaggagtct catctatctg     1080

ctgatgtcca atacctgctt catgtgttct cagagccctc atcacttccc atgccccatc     1140

tcgactccca tccccatcta tctgtgccct gagcatggct ctgcccccag gtcgtcttgc     1200

acaccttggc agccccctgt agttgacagg taagctgtag gcatgtagag caattgtccc     1260

aatgccactt gcttcctttc caagccgtcg aacagactgt gggatttgca gagtgtttct     1320

tccatgtctt tgaccacagg gttgttgctg cccaggctct agatcacatg gcatcaggct     1380

ggggcagagg catagctatt gtctcgggca tccttcccag ggttgggtct tacacaaata     1440

gaaggctctt gctctgagtt atgtgacatg cctcagcccc atggactaag caggggtctg     1500

gtataaaaac actcctggaa acgcctttgc cctgatccaa atgttagcac ttgctagtga     1560

acgtctactt atctcaagtt ctatgctaaa ggcaatttat cttgatgtga tgataaacca     1620

aacttattag caagatatgc atatatatcc ataaattctc tttactctgt ctccatcact     1680

tgatgcacat aagtgccctg acctcagcat ctcccctcta aaaaaaaaaa aaaaaaagta     1740

tctctttatc tttcttccat agcctgacac tgatatttgt gcacttacct taactttggt     1800

ctattttatt catccaaaac cattacattt cttggttttc acaaatgttc cccatttctt     1860

agccagttcc agacaatgta tagcaagcag gggaaggaaa gcagtcagga gttcctgggt     1920

ggccacggct ctgcaatagc acttatgtca tggaagtgat atcccacctc ctacatatac     1980

tctttgccta ggtttttgga acaaggttat agtcagacac tgtatcttta gattgatgtc     2040

gaccacaaag ttcagccaga gcttgaggct agatgcacag ccttgctatt gggaagaagg     2100

ccttttctag ctgtacaaca cagtctcact gggcattcat ccagaaatag agaagaaagt     2160

ctgccagact tgagttatgt tgtcttttat tagcagggaa tgtcatcaca gattggatag     2220

tacatccagg tgcaatgtca ccatcagcaa ggtcagcttg acactcaagt ggaagattag     2280

ggaagaatga ctaggataaa aaaaaaagga gggcaccaag ggaaagggat gatggggtga     2340

gctggcgagt gtgggtggga aatgaaatgt ttattgagga tctgctttgt gctgggcact     2400

ttaatccaca ttttatcgtt tacttttcaa acagatgcac cttaccccca ccccaatgct     2460

ctgtccctgc agatatcaga agacagtgtg attttcatgc tctgaagttc agttttacat     2520

ccaagcatcc ctctctgttt tttaacaatc caaagacagg ccaaaaaaag caccacagtt     2580

tattaagtac ttactaagca cccatccact gccccacact gtggcaagga ttgtgagggg     2640

taaagaagca tggggcacaa tattctgctg ccttcatgta acttacagtc tcacaaataa     2700

atagaacttc agttgaaata ctgacattaa ttaaatagag ttgtaataaa aaaaaaaaaa     2760

aaaaaaaaaa aaa                                                        2773


<210>  8
<211>  278
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Asp Phe Trp Leu Trp Pro Leu Tyr Phe Leu Pro Glu Tyr Glu Pro 
1               5                   10                  15      


Ser Trp Glu Glu Gln Pro Met Pro Glu Thr Pro Lys Trp Phe His Leu 
            20                  25                  30          


Pro Tyr Leu Phe Gln Met Pro Ala Tyr Ala Ser Ser Ser Lys Phe Val 
        35                  40                  45              


Thr Arg Val Thr Thr Pro Ala Gln Arg Gly Lys Val Pro Pro Val His 
    50                  55                  60                  


His Ser Ser Pro Thr Thr Gln Ile Thr His Arg Pro Arg Val Ser Arg 
65                  70                  75                  80  


Ala Ser Ser Val Ala Gly Asp Lys Pro Arg Thr Phe Leu Pro Ser Thr 
                85                  90                  95      


Thr Ala Ser Lys Ile Ser Ala Leu Glu Gly Leu Leu Lys Pro Gln Thr 
            100                 105                 110         


Pro Ser Tyr Asn His His Thr Arg Leu His Arg Gln Arg Ala Leu Asp 
        115                 120                 125             


Tyr Gly Ser Gln Ser Gly Arg Glu Gly Gln Gly Phe His Ile Leu Ile 
    130                 135                 140                 


Pro Thr Ile Leu Gly Leu Phe Leu Leu Ala Leu Leu Gly Leu Val Val 
145                 150                 155                 160 


Lys Arg Ala Val Glu Arg Arg Lys Ala Leu Ser Arg Arg Ala Arg Arg 
                165                 170                 175     


Leu Ala Val Arg Met Arg Ala Leu Glu Ser Ser Gln Arg Pro Arg Gly 
            180                 185                 190         


Ser Pro Arg Pro Arg Ser Gln Asn Asn Ile Tyr Ser Ala Cys Pro Arg 
        195                 200                 205             


Arg Ala Arg Gly Ala Asp Ala Ala Gly Thr Gly Glu Ala Pro Val Pro 
    210                 215                 220                 


Gly Pro Gly Ala Pro Leu Pro Pro Ala Pro Leu Gln Val Ser Glu Ser 
225                 230                 235                 240 


Pro Trp Leu His Ala Pro Ser Leu Lys Thr Ser Cys Glu Tyr Val Ser 
                245                 250                 255     


Leu Tyr His Gln Pro Ala Ala Met Met Glu Asp Ser Asp Ser Asp Asp 
            260                 265                 270         


Tyr Ile Asn Val Pro Ala 
        275             


<210>  9
<211>  2835
<212>  DNA
<213>  Homo sapiens

<400>  9
gggctcttgg atggaccttg cactctagaa gggacaatgg acttctggct ttggccactt       60

tacttcctgc cagtatcggg ggccctgagg atcctcccag aagtaaaggt agagggggag      120

ctgggcggat cagttaccat caagtgccca cttcctgaaa tgcatgtgag gatatatctg      180

tgccgggaga tggctggatc tggaacatgt ggtaccgtgg tatccaccac caacttcatc      240

aaggcagaat acaagggccg agttactctg aagcaatacc cacgcaagaa tctgttccta      300

gtggaggtaa cacagctgac agaaagtgac agcggagtct atgcctgcgg agcgggcatg      360

aacacagacc ggggaaagac ccagaaagtc accctgaatg tccacagtga atacgagcca      420

tcatgggaag agcagccaat gcctgagact ccaaaatggt ttcatctgcc ctatttgttc      480

cagatgcctg catatgccag ttcttccaaa ttcgtaacca gagttaccac accagctcaa      540

aggggcaagg tccctccagt tcaccactcc tcccccacca cccaaatcac ccaccgccct      600

cgagtgtcca gagcatcttc agtagcaggt gacaagcccc gaaccttcct gccatccact      660

acagcctcaa aaatctcagc tctggagggg ctgctcaagc cccagacgcc cagctacaac      720

caccacacca ggctgcacag gcagagccct ctccaggcgg gcccgccgac tggccgtgag      780

gatgcgcgcc ctggagagct cccagaggcc ccgcgggtcg ccgcgaccgc gctcccaaaa      840

caacatctac agcgcctgcc cgcggcgcgc tcgtggagcg gacgctgcag gcacagggga      900

ggcccccgtt cccggccccg gagcgccgtt gccccccgcc ccgctgcagg tgtctgaatc      960

tccctggctc catgccccat ctctgaagac cagctgtgaa tacgtgagcc tctaccacca     1020

gcctgccgcc atgatggagg acagtgattc agatgactac atcaatgttc ctgcctgaca     1080

actccccagc tatcccccaa ccccaggctc ggactgtggt gccaaggagt ctcatctatc     1140

tgctgatgtc caatacctgc ttcatgtgtt ctcagagccc tcatcacttc ccatgcccca     1200

tctcgactcc catccccatc tatctgtgcc ctgagcatgg ctctgccccc aggtcgtctt     1260

gcacaccttg gcagccccct gtagttgaca ggtaagctgt aggcatgtag agcaattgtc     1320

ccaatgccac ttgcttcctt tccaagccgt cgaacagact gtgggatttg cagagtgttt     1380

cttccatgtc tttgaccaca gggttgttgc tgcccaggct ctagatcaca tggcatcagg     1440

ctggggcaga ggcatagcta ttgtctcggg catccttccc agggttgggt cttacacaaa     1500

tagaaggctc ttgctctgag ttatgtgaca tgcctcagcc ccatggacta agcaggggtc     1560

tggtataaaa acactcctgg aaacgccttt gccctgatcc aaatgttagc acttgctagt     1620

gaacgtctac ttatctcaag ttctatgcta aaggcaattt atcttgatgt gatgataaac     1680

caaacttatt agcaagatat gcatatatat ccataaattc tctttactct gtctccatca     1740

cttgatgcac ataagtgccc tgacctcagc atctcccctc taaaaaaaaa aaaaaaaaag     1800

tatctcttta tctttcttcc atagcctgac actgatattt gtgcacttac cttaactttg     1860

gtctatttta ttcatccaaa accattacat ttcttggttt tcacaaatgt tccccatttc     1920

ttagccagtt ccagacaatg tatagcaagc aggggaagga aagcagtcag gagttcctgg     1980

gtggccacgg ctctgcaata gcacttatgt catggaagtg atatcccacc tcctacatat     2040

actctttgcc taggtttttg gaacaaggtt atagtcagac actgtatctt tagattgatg     2100

tcgaccacaa agttcagcca gagcttgagg ctagatgcac agccttgcta ttgggaagaa     2160

ggccttttct agctgtacaa cacagtctca ctgggcattc atccagaaat agagaagaaa     2220

gtctgccaga cttgagttat gttgtctttt attagcaggg aatgtcatca cagattggat     2280

agtacatcca ggtgcaatgt caccatcagc aaggtcagct tgacactcaa gtggaagatt     2340

agggaagaat gactaggata aaaaaaaaag gagggcacca agggaaaggg atgatggggt     2400

gagctggcga gtgtgggtgg gaaatgaaat gtttattgag gatctgcttt gtgctgggca     2460

ctttaatcca cattttatcg tttacttttc aaacagatgc accttacccc caccccaatg     2520

ctctgtccct gcagatatca gaagacagtg tgattttcat gctctgaagt tcagttttac     2580

atccaagcat ccctctctgt tttttaacaa tccaaagaca ggccaaaaaa agcaccacag     2640

tttattaagt acttactaag cacccatcca ctgccccaca ctgtggcaag gattgtgagg     2700

ggtaaagaag catggggcac aatattctgc tgccttcatg taacttacag tctcacaaat     2760

aaatagaact tcagttgaaa tactgacatt aattaaatag agttgtaata aaaaaaaaaa     2820

aaaaaaaaaa aaaaa                                                      2835


<210>  10
<211>  306
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Asp Phe Trp Leu Trp Pro Leu Tyr Phe Leu Pro Val Ser Gly Ala 
1               5                   10                  15      


Leu Arg Ile Leu Pro Glu Val Lys Val Glu Gly Glu Leu Gly Gly Ser 
            20                  25                  30          


Val Thr Ile Lys Cys Pro Leu Pro Glu Met His Val Arg Ile Tyr Leu 
        35                  40                  45              


Cys Arg Glu Met Ala Gly Ser Gly Thr Cys Gly Thr Val Val Ser Thr 
    50                  55                  60                  


Thr Asn Phe Ile Lys Ala Glu Tyr Lys Gly Arg Val Thr Leu Lys Gln 
65                  70                  75                  80  


Tyr Pro Arg Lys Asn Leu Phe Leu Val Glu Val Thr Gln Leu Thr Glu 
                85                  90                  95      


Ser Asp Ser Gly Val Tyr Ala Cys Gly Ala Gly Met Asn Thr Asp Arg 
            100                 105                 110         


Gly Lys Thr Gln Lys Val Thr Leu Asn Val His Ser Glu Tyr Glu Pro 
        115                 120                 125             


Ser Trp Glu Glu Gln Pro Met Pro Glu Thr Pro Lys Trp Phe His Leu 
    130                 135                 140                 


Pro Tyr Leu Phe Gln Met Pro Ala Tyr Ala Ser Ser Ser Lys Phe Val 
145                 150                 155                 160 


Thr Arg Val Thr Thr Pro Ala Gln Arg Gly Lys Val Pro Pro Val His 
                165                 170                 175     


His Ser Ser Pro Thr Thr Gln Ile Thr His Arg Pro Arg Val Ser Arg 
            180                 185                 190         


Ala Ser Ser Val Ala Gly Asp Lys Pro Arg Thr Phe Leu Pro Ser Thr 
        195                 200                 205             


Thr Ala Ser Lys Ile Ser Ala Leu Glu Gly Leu Leu Lys Pro Gln Thr 
    210                 215                 220                 


Pro Ser Tyr Asn His His Thr Arg Leu His Arg Gln Ser Pro Leu Gln 
225                 230                 235                 240 


Ala Gly Pro Pro Thr Gly Arg Glu Asp Ala Arg Pro Gly Glu Leu Pro 
                245                 250                 255     


Glu Ala Pro Arg Val Ala Ala Thr Ala Leu Pro Lys Gln His Leu Gln 
            260                 265                 270         


Arg Leu Pro Ala Ala Arg Ser Trp Ser Gly Arg Cys Arg His Arg Gly 
        275                 280                 285             


Gly Pro Arg Ser Arg Pro Arg Ser Ala Val Ala Pro Arg Pro Ala Ala 
    290                 295                 300                 


Gly Val 
305     


<210>  11
<211>  1893
<212>  DNA
<213>  Homo sapiens

<400>  11
gaaggatatt aaagagcacc tgcaggaatt ttttaagggg atgccggggg aagggcttga       60

aggaggaact aaggaggctt ccagaagatt ttgattaaca gcgagcgcta gggaaggcca      120

cggggataca gaggggtagg aggaggatcc agagacctcc aagttgtgga ctccggaggc      180

atcgagttcc tttcccagtt ttgtcaagaa ttccctgagc ggcagacacc ctcaaagtaa      240

aaaacgggaa ccacagagaa ggaaaaagaa gaaccacaag cgttttgaga aacaaacagg      300

ctgggcctag ggcctggggt gtgccctgca actggggggt ggggctggat gttcttggag      360

tcagggagca gcagcctccc acaggatgtg agagaggaac tggggtctcc agtcacggga      420

gccaggagcc ggccagggcc gcaggcagga agggagcgag gctgaaggga acgtcgtcct      480

ctcagcatgg gggtcccgcg gcctcagccc tgggcgctgg ggctcctgct ctttctcctt      540

cctgggagcc tgggcgcaga aagccacctc tccctcctgt accaccttac cgcggtgtcc      600

tcgcctgccc cggggactcc tgccttctgg gtgtccggct ggctgggccc gcagcagtac      660

ctgagctaca atagcctgcg gggcgaggcg gagccctgtg gagcttgggt ctgggaaaac      720

caggtgtcct ggtattggga gaaagagacc acagatctga ggatcaagga gaagctcttt      780

ctggaagctt tcaaagcttt ggggggaaaa ggtccctaca ctctgcaggg cctgctgggc      840

tgtgaactgg gccctgacaa cacctcggtg cccaccgcca agttcgccct gaacggcgag      900

gagttcatga atttcgacct caagcagggc acctggggtg gggactggcc cgaggccctg      960

gctatcagtc agcggtggca gcagcaggac aaggcggcca acaaggagct caccttcctg     1020

ctattctcct gcccgcaccg cctgcgggag cacctggaga ggggccgcgg aaacctggag     1080

tggaaggagc ccccctccat gcgcctgaag gcccgaccca gcagccctgg cttttccgtg     1140

cttacctgca gcgccttctc cttctaccct ccggagctgc aacttcggtt cctgcggaat     1200

gggctggccg ctggcaccgg ccagggtgac ttcggcccca acagtgacgg atccttccac     1260

gcctcgtcgt cactaacagt caaaagtggc gatgagcacc actactgctg cattgtgcag     1320

cacgcggggc tggcgcagcc cctcagggtg gagctggaat ctccagccaa gtcctccgtg     1380

ctcgtggtgg gaatcgtcat cggtgtcttg ctactcacgg cagcggctgt aggaggagct     1440

ctgttgtgga gaaggatgag gagtgggctg ccagcccctt ggatctccct tcgtggagac     1500

gacaccgggg tcctcctgcc caccccaggg gaggcccagg atgctgattt gaaggatgta     1560

aatgtgattc cagccaccgc ctgaccatcc gccattccga ctgctaaaag cgaatgtagt     1620

caggcccctt tcatgctgtg agacctcctg gaacactggc atctctgagc ctccagaagg     1680

ggttctgggc ctagttgtcc tccctctgga gccccgtcct gtggtctgcc tcagtttccc     1740

ctcctaatac atatggctgt tttccacctc gataatataa cacgagtttg ggcccgaatc     1800

agtgtgttct catcattttt caggcagggg aggtaaggga ataagtcggg ggactgaatg     1860

gcggctgggc ctcggatctc tcctacaggt aac                                  1893


<210>  12
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
    130                 135                 140                 


Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
145                 150                 155                 160 


Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                165                 170                 175     


Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                245                 250                 255     


Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
            260                 265                 270         


Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
        275                 280                 285             


Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
    290                 295                 300                 


Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
305                 310                 315                 320 


Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                325                 330                 335     


Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
            340                 345                 350         


Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
        355                 360                 365 


<210>  13
<211>  1629
<212>  DNA
<213>  Homo sapiens

<400>  13
agcctatcaa gtgtctgtaa ttaattaacc aactgagatc cagttcaggg gtgaaagttc       60

ttcaggtacg aggagggcat tgttgtcagt ctggaccgag cccgcagagc ccctcctcgg      120

cgtcctggtc ccggccgtgc ccgcggtgtc ccgggaggaa ggggcgggcc gggggtcggg      180

aggagtcacg tgccccctcc cgccccaggt cgtcctctca gcatgggggt cccgcggcct      240

cagccctggg cgctggggct cctgctcttt ctccttcctg ggagcctggg cgcagaaagc      300

cacctctccc tcctgtacca ccttaccgcg gtgtcctcgc ctgccccggg gactcctgcc      360

ttctgggtgt ccggctggct gggcccgcag cagtacctga gctacaatag cctgcggggc      420

gaggcggagc cctgtggagc ttgggtctgg gaaaaccagg tgtcctggta ttgggagaaa      480

gagaccacag atctgaggat caaggagaag ctctttctgg aagctttcaa agctttgggg      540

ggaaaaggtc cctacactct gcagggcctg ctgggctgtg aactgggccc tgacaacacc      600

tcggtgccca ccgccaagtt cgccctgaac ggcgaggagt tcatgaattt cgacctcaag      660

cagggcacct ggggtgggga ctggcccgag gccctggcta tcagtcagcg gtggcagcag      720

caggacaagg cggccaacaa ggagctcacc ttcctgctat tctcctgccc gcaccgcctg      780

cgggagcacc tggagagggg ccgcggaaac ctggagtgga aggagccccc ctccatgcgc      840

ctgaaggccc gacccagcag ccctggcttt tccgtgctta cctgcagcgc cttctccttc      900

taccctccgg agctgcaact tcggttcctg cggaatgggc tggccgctgg caccggccag      960

ggtgacttcg gccccaacag tgacggatcc ttccacgcct cgtcgtcact aacagtcaaa     1020

agtggcgatg agcaccacta ctgctgcatt gtgcagcacg cggggctggc gcagcccctc     1080

agggtggagc tggaatctcc agccaagtcc tccgtgctcg tggtgggaat cgtcatcggt     1140

gtcttgctac tcacggcagc ggctgtagga ggagctctgt tgtggagaag gatgaggagt     1200

gggctgccag ccccttggat ctcccttcgt ggagacgaca ccggggtcct cctgcccacc     1260

ccaggggagg cccaggatgc tgatttgaag gatgtaaatg tgattccagc caccgcctga     1320

ccatccgcca ttccgactgc taaaagcgaa tgtagtcagg cccctttcat gctgtgagac     1380

ctcctggaac actggcatct ctgagcctcc agaaggggtt ctgggcctag ttgtcctccc     1440

tctggagccc cgtcctgtgg tctgcctcag tttcccctcc taatacatat ggctgttttc     1500

cacctcgata atataacacg agtttgggcc cgaatcagtg tgttctcatc atttttcagg     1560

caggggaggt aagggaataa gtcgggggac tgaatggcgg ctgggcctcg gatctctcct     1620

acaggtaac                                                             1629


<210>  14
<211>  365
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Val Pro Arg Pro Gln Pro Trp Ala Leu Gly Leu Leu Leu Phe 
1               5                   10                  15      


Leu Leu Pro Gly Ser Leu Gly Ala Glu Ser His Leu Ser Leu Leu Tyr 
            20                  25                  30          


His Leu Thr Ala Val Ser Ser Pro Ala Pro Gly Thr Pro Ala Phe Trp 
        35                  40                  45              


Val Ser Gly Trp Leu Gly Pro Gln Gln Tyr Leu Ser Tyr Asn Ser Leu 
    50                  55                  60                  


Arg Gly Glu Ala Glu Pro Cys Gly Ala Trp Val Trp Glu Asn Gln Val 
65                  70                  75                  80  


Ser Trp Tyr Trp Glu Lys Glu Thr Thr Asp Leu Arg Ile Lys Glu Lys 
                85                  90                  95      


Leu Phe Leu Glu Ala Phe Lys Ala Leu Gly Gly Lys Gly Pro Tyr Thr 
            100                 105                 110         


Leu Gln Gly Leu Leu Gly Cys Glu Leu Gly Pro Asp Asn Thr Ser Val 
        115                 120                 125             


Pro Thr Ala Lys Phe Ala Leu Asn Gly Glu Glu Phe Met Asn Phe Asp 
    130                 135                 140                 


Leu Lys Gln Gly Thr Trp Gly Gly Asp Trp Pro Glu Ala Leu Ala Ile 
145                 150                 155                 160 


Ser Gln Arg Trp Gln Gln Gln Asp Lys Ala Ala Asn Lys Glu Leu Thr 
                165                 170                 175     


Phe Leu Leu Phe Ser Cys Pro His Arg Leu Arg Glu His Leu Glu Arg 
            180                 185                 190         


Gly Arg Gly Asn Leu Glu Trp Lys Glu Pro Pro Ser Met Arg Leu Lys 
        195                 200                 205             


Ala Arg Pro Ser Ser Pro Gly Phe Ser Val Leu Thr Cys Ser Ala Phe 
    210                 215                 220                 


Ser Phe Tyr Pro Pro Glu Leu Gln Leu Arg Phe Leu Arg Asn Gly Leu 
225                 230                 235                 240 


Ala Ala Gly Thr Gly Gln Gly Asp Phe Gly Pro Asn Ser Asp Gly Ser 
                245                 250                 255     


Phe His Ala Ser Ser Ser Leu Thr Val Lys Ser Gly Asp Glu His His 
            260                 265                 270         


Tyr Cys Cys Ile Val Gln His Ala Gly Leu Ala Gln Pro Leu Arg Val 
        275                 280                 285             


Glu Leu Glu Ser Pro Ala Lys Ser Ser Val Leu Val Val Gly Ile Val 
    290                 295                 300                 


Ile Gly Val Leu Leu Leu Thr Ala Ala Ala Val Gly Gly Ala Leu Leu 
305                 310                 315                 320 


Trp Arg Arg Met Arg Ser Gly Leu Pro Ala Pro Trp Ile Ser Leu Arg 
                325                 330                 335     


Gly Asp Asp Thr Gly Val Leu Leu Pro Thr Pro Gly Glu Ala Gln Asp 
            340                 345                 350         


Ala Asp Leu Lys Asp Val Asn Val Ile Pro Ala Thr Ala 
        355                 360                 365 


<210>  15
<211>  2812
<212>  DNA
<213>  Homo sapiens

<400>  15
agctgggctt tgtggagcgc tgcggagggt gcgtgcgggc cgcggcagcc gaacaaagga       60

gcaggggcgc cgccgcaggg acccgccacc cacctcccgg ggccgcgcag cggcctctcg      120

tctactgcca ccatgaccgc caacggcaca gccgaggcgg tgcagatcca gttcggcctc      180

atcaactgcg gcaacaagta cctgacggcc gaggcgttcg ggttcaaggt gaacgcgtcc      240

gccagcagcc tgaagaagaa gcagatctgg acgctggagc agccccctga cgaggcgggc      300

agcgcggccg tgtgcctgcg cagccacctg ggccgctacc tggcggcgga caaggacggc      360

aacgtgacct gcgagcgcga ggtgcccggt cccgactgcc gtttcctcat cgtggcgcac      420

gacgacggtc gctggtcgct gcagtccgag gcgcaccggc gctacttcgg cggcaccgag      480

gaccgcctgt cctgcttcgc gcagacggtg tcccccgccg agaagtggag cgtgcacatc      540

gccatgcacc ctcaggtcaa catctacagc gtcacccgta agcgctacgc gcacctgagc      600

gcgcggccgg ccgacgagat cgccgtggac cgcgacgtgc cctggggcgt cgactcgctc      660

atcaccctcg ccttccagga ccagcgctac agcgtgcaga ccgccgacca ccgcttcctg      720

cgccacgacg ggcgcctggt ggcgcgcccc gagccggcca ctggctacac gctggagttc      780

cgctccggca aggtggcctt ccgcgactgc gagggccgtt acctggcgcc gtcggggccc      840

agcggcacgc tcaaggcggg caaggccacc aaggtgggca aggacgagct ctttgctctg      900

gagcagagct gcgcccaggt cgtgctgcag gcggccaacg agaggaacgt gtccacgcgc      960

cagggtatgg acctgtctgc caatcaggac gaggagaccg accaggagac cttccagctg     1020

gagatcgacc gcgacaccaa aaagtgtgcc ttccgtaccc acacgggcaa gtactggacg     1080

ctgacggcca ccgggggcgt gcagtccacc gcctccagca agaatgccag ctgctacttt     1140

gacatcgagt ggcgtgaccg gcgcatcaca ctgagggcgt ccaatggcaa gtttgtgacc     1200

tccaagaaga atgggcagct ggccgcctcg gtggagacag caggggactc agagctcttc     1260

ctcatgaagc tcatcaaccg ccccatcatc gtgttccgcg gggagcatgg cttcatcggc     1320

tgccgcaagg tcacgggcac cctggacgcc aaccgctcca gctatgacgt cttccagctg     1380

gagttcaacg atggcgccta caacatcaaa gactccacag gcaaatactg gacggtgggc     1440

agtgactccg cggtcaccag cagcggcgac actcctgtgg acttcttctt cgagttctgc     1500

gactataaca aggtggccat caaggtgggc gggcgctacc tgaagggcga ccacgcaggc     1560

gtcctgaagg cctcggcgga aaccgtggac cccgcctcgc tctgggagta ctagggccgg     1620

cccgtccttc cccgcccctg cccacatggc ggctcctgcc aaccctccct gctaacccct     1680

tctccgccag gtgggctcca gggcgggagg caagccccct tgcctttcaa actggaaacc     1740

ccagagaaaa cggtgccccc acctgtcgcc cctatggact ccccactctc ccctccgccc     1800

gggttcccta ctcccctcgg gtcagcggct gcggcctggc cctgggaggg atttcagatg     1860

cccctgccct cttgtctgcc acggggcgag tctggcacct ctttcttctg acctcagacg     1920

gctctgagcc ttatttctct ggaagcggct aagggacggt tgggggctgg gagccctggg     1980

cgtgtagtgt aactggaatc ttttgcctct cccagccacc tcctcccagc cccccaggag     2040

agctgggcac atgtcccaag cctgtcagtg gccctccctg gtgcactgtc cccgaaaccc     2100

ctgcttggga agggaagctg tcgggtgggc taggactgac ccttgtggtg tttttttggg     2160

tggtggctgg aaacagcccc tctcccacgt ggcagaggct cagcctggct cccttccctg     2220

gagcggcagg gcgtgacggc cacagggtct gcccgctgca cgttctgcca aggtggtggt     2280

ggcgggcggg taggggtgtg ggggccgtct tcctcctgtc tctttccttt caccctagcc     2340

tgactggaag cagaaaatga ccaaatcagt atttttttta atgaaatatt attgctggag     2400

gcgtcccagg caagcctggc tgtagtagcg agtgatctgg cggggggcgt ctcagcaccc     2460

tccccagggg gtgcatctca gccccctctt tccgtccttc ccgtccagcc ccagccctgg     2520

gcctgggctg ccgacacctg ggccagagcc cctgctgtga ttggtgctcc ctgggcctcc     2580

cgggtggatg aagccaggcg tcgccccctc cgggagccct ggggtgagcc gccggggccc     2640

ccctgctgcc agcctccccc gtccccaaca tgcatctcac tctgggtgtc ttggtctttt     2700

attttttgta agtgtcattt gtataactct aaacgcccat gatagtagct tcaaactgga     2760

aatagcgaaa taaaataact cagtctgcag ccccagaaaa aaaaaaaaaa aa             2812


<210>  16
<211>  493
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Thr Ala Asn Gly Thr Ala Glu Ala Val Gln Ile Gln Phe Gly Leu 
1               5                   10                  15      


Ile Asn Cys Gly Asn Lys Tyr Leu Thr Ala Glu Ala Phe Gly Phe Lys 
            20                  25                  30          


Val Asn Ala Ser Ala Ser Ser Leu Lys Lys Lys Gln Ile Trp Thr Leu 
        35                  40                  45              


Glu Gln Pro Pro Asp Glu Ala Gly Ser Ala Ala Val Cys Leu Arg Ser 
    50                  55                  60                  


His Leu Gly Arg Tyr Leu Ala Ala Asp Lys Asp Gly Asn Val Thr Cys 
65                  70                  75                  80  


Glu Arg Glu Val Pro Gly Pro Asp Cys Arg Phe Leu Ile Val Ala His 
                85                  90                  95      


Asp Asp Gly Arg Trp Ser Leu Gln Ser Glu Ala His Arg Arg Tyr Phe 
            100                 105                 110         


Gly Gly Thr Glu Asp Arg Leu Ser Cys Phe Ala Gln Thr Val Ser Pro 
        115                 120                 125             


Ala Glu Lys Trp Ser Val His Ile Ala Met His Pro Gln Val Asn Ile 
    130                 135                 140                 


Tyr Ser Val Thr Arg Lys Arg Tyr Ala His Leu Ser Ala Arg Pro Ala 
145                 150                 155                 160 


Asp Glu Ile Ala Val Asp Arg Asp Val Pro Trp Gly Val Asp Ser Leu 
                165                 170                 175     


Ile Thr Leu Ala Phe Gln Asp Gln Arg Tyr Ser Val Gln Thr Ala Asp 
            180                 185                 190         


His Arg Phe Leu Arg His Asp Gly Arg Leu Val Ala Arg Pro Glu Pro 
        195                 200                 205             


Ala Thr Gly Tyr Thr Leu Glu Phe Arg Ser Gly Lys Val Ala Phe Arg 
    210                 215                 220                 


Asp Cys Glu Gly Arg Tyr Leu Ala Pro Ser Gly Pro Ser Gly Thr Leu 
225                 230                 235                 240 


Lys Ala Gly Lys Ala Thr Lys Val Gly Lys Asp Glu Leu Phe Ala Leu 
                245                 250                 255     


Glu Gln Ser Cys Ala Gln Val Val Leu Gln Ala Ala Asn Glu Arg Asn 
            260                 265                 270         


Val Ser Thr Arg Gln Gly Met Asp Leu Ser Ala Asn Gln Asp Glu Glu 
        275                 280                 285             


Thr Asp Gln Glu Thr Phe Gln Leu Glu Ile Asp Arg Asp Thr Lys Lys 
    290                 295                 300                 


Cys Ala Phe Arg Thr His Thr Gly Lys Tyr Trp Thr Leu Thr Ala Thr 
305                 310                 315                 320 


Gly Gly Val Gln Ser Thr Ala Ser Ser Lys Asn Ala Ser Cys Tyr Phe 
                325                 330                 335     


Asp Ile Glu Trp Arg Asp Arg Arg Ile Thr Leu Arg Ala Ser Asn Gly 
            340                 345                 350         


Lys Phe Val Thr Ser Lys Lys Asn Gly Gln Leu Ala Ala Ser Val Glu 
        355                 360                 365             


Thr Ala Gly Asp Ser Glu Leu Phe Leu Met Lys Leu Ile Asn Arg Pro 
    370                 375                 380                 


Ile Ile Val Phe Arg Gly Glu His Gly Phe Ile Gly Cys Arg Lys Val 
385                 390                 395                 400 


Thr Gly Thr Leu Asp Ala Asn Arg Ser Ser Tyr Asp Val Phe Gln Leu 
                405                 410                 415     


Glu Phe Asn Asp Gly Ala Tyr Asn Ile Lys Asp Ser Thr Gly Lys Tyr 
            420                 425                 430         


Trp Thr Val Gly Ser Asp Ser Ala Val Thr Ser Ser Gly Asp Thr Pro 
        435                 440                 445             


Val Asp Phe Phe Phe Glu Phe Cys Asp Tyr Asn Lys Val Ala Ile Lys 
    450                 455                 460                 


Val Gly Gly Arg Tyr Leu Lys Gly Asp His Ala Gly Val Leu Lys Ala 
465                 470                 475                 480 


Ser Ala Glu Thr Val Asp Pro Ala Ser Leu Trp Glu Tyr 
                485                 490             


<210>  17
<211>  3289
<212>  DNA
<213>  Homo sapiens

<400>  17
cgcggagcgg aggccgaggc gagagcctgg cgctgtagga ctagaacgaa aggagtgagg       60

cgccgagagc ccagatacca ttttggcgtg agagctggtg gttggcaagg ccgcgggagt      120

gggaagcgtc cgccatgttc tgcgaaaaag ccatggaact gatccgcgag ctgcatcgcg      180

cgcccgaagg gcaactgcct gccttcaacg aggatggact cagacaagtt ctggaggaga      240

tgaaagcttt gtatgaacaa aaccagtctg atgtgaatga agcaaagtca ggtggacgaa      300

gtgatttgat accaactatc aaatttcgac actgttctct gttaagaaat cgacgctgca      360

ctgtagcata cctgtatgac cgcttgcttc ggatcagagc actcagatgg gaatatggta      420

gcgtcttgcc aaatgcatta cgatttcaca tggctgctga agaaatggag tggtttaata      480

attataaaag atctcttgct acttatatga ggtcactggg aggagatgaa ggtttggaca      540

ttacacagga tatgaaacca ccaaaaagcc tatatattga agtccggtgt ctaaaagact      600

atggagaatt tgaagttgat gatggcactt cagtcctatt aaaaaaaaat agccagcact      660

ttttacctcg atggaaatgt gagcagctga tcagacaagg agtcctggag cacatcctgt      720

catgaccatg cgccgaggca cttccaggct tcactcaact catggactcc tctgtactca      780

ctctctccac cactcccttc acctccctct ttgattttag aagctataga cattgtttaa      840

gataactaag aatacttggc taagaagtat aatttgctaa ctattaagga ctttcttttt      900

ttaatgttgt acactattct tcctactctt ttttggtttt ggttttgttt tgtagagact      960

gtctcactat gttgcccaag ctggtctcaa actcctggcc tcaagcagtc ctcccacctt     1020

agcttctcaa agtgttgaga tcacaggcgt gagccactgc acccggcccc tactcctttt     1080

tctaataagc tgtatctgta atcacagcat tcctacagtt gttacagtgt gttttttaaa     1140

tgaaagtaaa catggttaca tttgaatctc ttaaataagc agtcacttgg ctggacagga     1200

agaaggtaga tcctgtgtgt cttgttttct ggtcatgtgt attgtacaag ctagagagct     1260

gaatttctga gatacacatt ttcaaatcac atgcaagtga agatgatggt ctgtagaaat     1320

tttcagtata tataatgttt aatgacatac taatttatca tctggctatt tgggaaggaa     1380

ggacacacat ggattttgca catttccacc atggtggctg gtgtggcttg tggctatggg     1440

gtgatcacca gtatcaccac tttggaaggg gacagtgaaa ttggggctag agaaggaact     1500

ttgtacagtt ttccctgaga ttcagattga ctgaaaagtc acatgaagag ttgattgtct     1560

tttaatggta tgttttaaac agctgacatt ttaaattttg atgaaatcca gtttattcgt     1620

ttgttctttt atgctttggg tgttgcatcc gagaaatctt ttcccatccc aagatcacaa     1680

ttttttttcc tttttacttc tagaagtgtt ataattttaa gctttatact ttggtctatg     1740

acccgttttt ttttttgttt tgttttgttt tttcgtttgt ttctttgttt tgagatggag     1800

tcttgttctg tcacccaggc tggggtgcag tggcgtgatc ttggctcact gcaatctcta     1860

tcccctgggt tcaagtgatt ctcttgtctc agcctcccaa gtagctggga ttacaggcac     1920

aggccgccac gcctggctaa tttttgtatt tttagtagag acagagtttt accatgttgg     1980

ccaggctggt ttcaaactcc tgacctcaag tgacccacct tggcctccca aagttttggg     2040

attacaagtg tgggccaccg cggccagcct atgatccatt ttgaatgaat tttttatatg     2100

gtgcaaggtg tcaatccacc ttcacttttt cttgggaata tagatatcca gctgtttcac     2160

taccattttt tgaaaggact gccctttgct ctatcacctt tgcatttttg ttaaaaagta     2220

gttgtcaatg tatatgtggg tttatttcag gactctgttt tgttccattg acctgttttt     2280

ctctcctgaa tgccaatacc atatttgtat gtagtgtatg taattttcta ataattcttg     2340

aaacagatag tattaatgtg tcatattttt gctgttgttt gtattttttg tagagatggg     2400

gtttcaccgt gttggccagg ctgtgttgaa ctcctgagct aaagcaatac acttgcctcg     2460

tcctccccat gtgctgggat tacaggcgtg agccttggtg ctggcccagt gtaccacatt     2520

tctttttgag atttgttttg gctatgttaa gtcctttgct tttgatgtga aatttgggaa     2580

caggcagggt gtggtggctt atgcctgtaa tcctagaact ttgggaggcc tagatgggtg     2640

gatcacttga gctcaggagt tccagaccag cccgggccta tggcaaaact ccgtctctac     2700

aaaaaataga aaaaattagc caggtgtggt ggtgcatgcc tgtagtcaca gttacacggc     2760

aggctgaggt gggaggatca cttgaacccc agaggtcaag actgcagtga gctgagatca     2820

caccactgta ctccagcctg ggtgacaaag tgagactcta tctcaaaaag aaattaggat     2880

caatttgtca atttctacaa caacaacaac aaaaacccct gttgggcacc ttgattgaga     2940

ttgcattgaa tttatataaa actgttggga gaattgacat cttaataata ttgagtcttc     3000

tggcctataa acaaggtctg tcttcctagg tattaatgtt ttgtcttcta tttctcttaa     3060

taatcttttg tagttttcag tgtacaggtc taccatgtca gcatttcata gttttgatgc     3120

taaatggtat tttaaaattt caaattctaa ccacttgttg ctagtaaata gaaatacaat     3180

tgatgttgaa cttgtatcct tcagccttgc taaactgtga gttctcatgg tgtttttgta     3240

aattacatca acagtcatgt gttctatgaa taaagagttt tactccttc                 3289


<210>  18
<211>  196
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Phe Cys Glu Lys Ala Met Glu Leu Ile Arg Glu Leu His Arg Ala 
1               5                   10                  15      


Pro Glu Gly Gln Leu Pro Ala Phe Asn Glu Asp Gly Leu Arg Gln Val 
            20                  25                  30          


Leu Glu Glu Met Lys Ala Leu Tyr Glu Gln Asn Gln Ser Asp Val Asn 
        35                  40                  45              


Glu Ala Lys Ser Gly Gly Arg Ser Asp Leu Ile Pro Thr Ile Lys Phe 
    50                  55                  60                  


Arg His Cys Ser Leu Leu Arg Asn Arg Arg Cys Thr Val Ala Tyr Leu 
65                  70                  75                  80  


Tyr Asp Arg Leu Leu Arg Ile Arg Ala Leu Arg Trp Glu Tyr Gly Ser 
                85                  90                  95      


Val Leu Pro Asn Ala Leu Arg Phe His Met Ala Ala Glu Glu Met Glu 
            100                 105                 110         


Trp Phe Asn Asn Tyr Lys Arg Ser Leu Ala Thr Tyr Met Arg Ser Leu 
        115                 120                 125             


Gly Gly Asp Glu Gly Leu Asp Ile Thr Gln Asp Met Lys Pro Pro Lys 
    130                 135                 140                 


Ser Leu Tyr Ile Glu Val Arg Cys Leu Lys Asp Tyr Gly Glu Phe Glu 
145                 150                 155                 160 


Val Asp Asp Gly Thr Ser Val Leu Leu Lys Lys Asn Ser Gln His Phe 
                165                 170                 175     


Leu Pro Arg Trp Lys Cys Glu Gln Leu Ile Arg Gln Gly Val Leu Glu 
            180                 185                 190         


His Ile Leu Ser 
        195     


<210>  19
<211>  5778
<212>  DNA
<213>  Homo sapiens

<400>  19
gtgacacaat tacaacaact ttgtgctggt gccggggaag tttgtgtctc caacgaatcc       60

cctcagtgct ccccagcccc gcgcgctccg gccgttcccg ccgtccccgc ctgtggctgc      120

cccctgccca accccgcgat gtgaccctac agccgaaagc cgccgctgcc gacccggggg      180

ctccgcagcc cctgccgccg ccgccgccgc cttcaccgcc gccgcgttgg gatttttcgt      240

cgccgccgcc cgcggcggag gaggaggcgg cgataaagtt ggtgtgctgg tcccgcgcgc      300

agattggggg cgtcactgcg ggccccggtc cgaggggggg tgtcggcgtt ggagttgtga      360

attcgctgcg tttccatgaa atcctgcgga gtgtcgctcg ctaccgccgc cgctgccgcc      420

gccgctttcg gtgatgagga aaagaaaatg gcggcgggaa aagcgagcgg cgagagcgag      480

gaggcgtccc ccagcctgac agccgaggag agggaggcgc tcggcggact ggacagccgc      540

ctctttgggt tcgtgagatt tcatgaagat ggcgccagga cgaaggccct actgggcaag      600

gctgttcgct gctatgaatc tctaatctta aaagctgaag gaaaagtgga gtctgatttc      660

ttttgtcaat taggtcactt caacctctta ttggaagatt atccaaaagc attatctgca      720

taccagaggt actacagttt acagtctgac tactggaaga atgctgcctt tttatatggt      780

cttggtttgg tctacttcca ttataatgca tttcagtggg caattaaagc atttcaggag      840

gtgctttatg ttgatcccag cttttgtcga gccaaggaaa ttcatttacg acttgggctt      900

atgttcaaag tgaacacaga ctatgagtct agtttaaagc attttcagtt agctttggtt      960

gactgtaatc cctgcacttt gtccaatgct gaaattcaat ttcacattgc ccacttatat     1020

gaaacccaga ggaaatatca ttctgcaaaa gaagcttatg aacaactttt gcagacagag     1080

aatctttctg cacaagtaaa agcaactgtc ttacaacagt taggttggat gcatcacact     1140

gtagatctcc tgggagataa agccaccaag gaaagctatg ctattcagta tctccaaaag     1200

tccttggaag cagatcctaa ttctggccag tcctggtatt tcctcggaag gtgctattca     1260

agtattggga aagttcagga tgcctttata tcttacaggc agtctattga taaatcagaa     1320

gcaagtgcag atacatggtg ttcaataggt gtgctatatc agcagcaaaa tcagcccatg     1380

gatgctttac aggcctatat ttgtgctgta caattggacc atggccatgc tgcagcctgg     1440

atggacctag gcactctcta tgaatcctgc aaccagcctc aggatgccat taaatgctac     1500

ttaaatgcaa ctagaagcaa aagttgtagt aatacctctg cacttgcagc acgaattaag     1560

tatttacagg ctcagttgtg taaccttcca caaggtagtc tacagaataa aactaaatta     1620

cttcctagta ttgaggaggc gtggagccta ccaattcccg cagagcttac ctccaggcag     1680

ggtgccatga acacagcaca gcagaatact tctgacaatt ggagtggtgg acatgctgtg     1740

tcacatcctc cagtacagca acaagctcat tcatggtgtt tgacaccaca gaaattacag     1800

catttggaac agctccgcgc aaatagaaat aatttaaatc cagcacagaa actgatgctg     1860

gaacagctgg aaagtcagtt tgtcttaatg caacaacacc aaatgagacc aacaggagtt     1920

gcacaggtac gatctactgg aattcctaat gggccaacag ctgactcatc actgcctaca     1980

aactcagtct ctggccagca gccacagctt gctctgacca gagtgcctag cgtctctcag     2040

cctggagtcc gtcctgcctg ccctgggcag cctttggcca atggaccctt ttctgcaggc     2100

catgttccct gtagcacatc aagaacgctg ggaagtacag acactatttt gataggcaat     2160

aatcatataa caggaagtgg aagtaatgga aacgtgcctt acctgcagcg aaacgcactc     2220

actctacctc ataaccgcac aaacctgacc agcagcgcag aggagccgtg gaaaaaccaa     2280

ctatctaact ccactcaggg gcttcacaaa ggtcagagtt cacattcggc aggtcctaat     2340

ggtgaacgac ctctctcttc cactgggcct tcccagcatc tccaggcagc tggctctggt     2400

attcagaatc agaacggaca tcccaccctg cctagcaatt cagtaacaca gggggctgct     2460

ctcaatcacc tctcctctca cactgctacc tcaggtggac aacaaggcat taccttaacc     2520

aaagagagca agccttcagg aaacatattg acggtgcctg aaacaagcag gcacactgga     2580

gagacaccta acagcactgc cagtgtcgag ggacttccta atcatgtcca tcagatgacg     2640

gcagatgctg tttgcagtcc tagccatgga gattctaagt caccaggttt actaagttca     2700

gacaatcctc agctctctgc cttgttgatg ggaaaagcca ataacaatgt gggtactgga     2760

acctgtgaca aagtcaataa catccaccca gctgttcata caaagactga taactctgtt     2820

gcctcttcac catcttcagc catttcaaca gcaacacctt ctccaaaatc cactgagcag     2880

acaaccacaa acagtgttac cagccttaac agccctcaca gtgggctaca cacaattaat     2940

ggagaaggga tggaagaatc tcagagcccc atgaaaacag atctgcttct ggttaaccac     3000

aaacctagtc cacagatcat accatcaatg tctgtgtcca tataccccag ctcagcagaa     3060

gttctgaagg catgcaggaa tctaggtaaa aatggcttat ctaacagtag cattttgttg     3120

gataaatgtc cacctccaag accaccatct tcaccatacc ctcccttgcc aaaggacaag     3180

ttgaatccac ctacacctag tatttacttg gaaaataaac gtgatgcttt ctttcctcca     3240

ttacatcaat tttgtacaaa tccgaacaac cctgttacag taatacgtgg ccttgctgga     3300

gctcttaagt tagacctggg acttttctct actaaaactt tggtggaagc taacaatgaa     3360

catatggtag aagtgaggac acagttgttg cagccagcag atgaaaactg ggatcccact     3420

ggaacaaaga aaatctggca ttgtgaaagt aatagatctc atactacaat tgctaaatat     3480

gcacagtacc aggcctcctc attccaggaa tcattgagag aagaaaatga aaaaagaagt     3540

catcataaag accactcaga tagtgaatct acatcgtcag ataattctgg gaggaggagg     3600

aaaggaccct ttaaaaccat aaagtttggg accaatattg acctatctga tgacaaaaag     3660

tggaagttgc agctacatga gctgactaaa cttcctgctt ttgtgcgtgt cgtatcagca     3720

ggaaatcttc taagccatgt tggtcatacc atattgggca tgaacacagt tcaactatac     3780

atgaaagttc cagggagcag aacaccaggt catcaggaaa ataacaactt ctgttcagtt     3840

aacataaata ttggcccagg tgactgtgaa tggtttgttg ttcctgaagg ttactggggt     3900

gttctgaatg acttctgtga aaaaaataat ttgaatttcc taatgggttc ttggtggccc     3960

aatcttgaag atctttatga agcaaatgtt ccagtgtata ggtttattca gcgacctgga     4020

gatttggtct ggataaatgc aggcactgtt cattgggttc aggctattgg ctggtgcaac     4080

aacattgctt ggaatgttgg tccacttaca gcctgccagt ataaattggc agtggaacgg     4140

tacgaatgga acaaattgca aagtgtgaag tcaatagtac ccatggttca tctttcctgg     4200

aatatggcac gaaatatcaa ggtctcagat ccaaagcttt ttgaaatgat taagtattgt     4260

cttctaagaa ctctgaagca atgtcagaca ttgagggaag ctctcattgc tgcaggaaaa     4320

gagattatat ggcatgggcg gacaaaagaa gaaccagctc attactgtag catttgtgaa     4380

gtggaggttt ttgatctgct ttttgtcact aatgagagta attcacgaaa gacctacata     4440

gtacattgcc aagattgtgc acgaaaaaca agcggaaact tggaaaactt tgtggtgcta     4500

gaacagtaca aaatggagga cctgatgcaa gtctatgacc aatttacatt agctcctcca     4560

ttaccatccg cctcatcttg atattgttcc atggacatta aatgagacct tttctgctat     4620

tcaggaaata acccagttct gcaccactgg tttttgtagc tatctcgtaa ggctgctggc     4680

tgaaaactgt gtctatgcaa ccttccaagt gcggagtgtc aaccaactgg acgggagaga     4740

gtactgctcc tactccagga ctctcacaaa gctgatgagc tgtacttcag aaaaaaataa     4800

taatttccat gttttgtata tatctgacaa aactggcaac atcttacaga ctactgactt     4860

gaagacaacc tcttttatat ttctctattt ctgggctgat gaatttgttt tcatctgtct     4920

tttccccctt cagaattttc cttggaaaaa aaatactagc ctagctggtc atttctttgt     4980

aaggtagtta gcaattttaa gtctttcttt ggtcaacttt tttttaatgt gaaaagttag     5040

gtaagacact tttttactgc ttttatgttt ttctgtcttg ttttgagacc atgatggtta     5100

cacttttggt tcctaaataa aatttaaaaa attaacagcc aagtcacaaa ggtaatggat     5160

tgcacataga ctaaggaata aacttcagat ttgtgatttt tgtttctaat cttgatgtaa     5220

atttacacta tttataaata catatttatt gcttgaaaat atttgtgaat ggaatgctgt     5280

tattttttcc agatttacct gccattgaaa ttttaaggag ttctgtaatt tcaaacacta     5340

ctcctattac attttctatg tgtaaataaa actgcttagc attgtacaga aacttttatt     5400

aaaattgttt aatgtttaaa gagttttcta ttgtttgagt tttaaaaaag actttatgta     5460

cagtgcccag tttttgttca tttttgaaat ctgattatat atattttata tatacttatg     5520

tatgtatata taatatatat agaaatctgg atatatatgt ataaatcttt agaacttaaa     5580

tttttctcgt tttaagtttc acatctatgg tagatttttg aggtgtctac tgtaaagtat     5640

tgcttacaaa aagtatgatt atttttaaag aaatatatat ggtatgtatc ctcaagacct     5700

aaaatgtcag actggtttat tgttaagttg caattactgc aatgacagac caataaacaa     5760

ttgctgccaa aaaaaaaa                                                   5778


<210>  20
<211>  1401
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Lys Ser Cys Gly Val Ser Leu Ala Thr Ala Ala Ala Ala Ala Ala 
1               5                   10                  15      


Ala Phe Gly Asp Glu Glu Lys Lys Met Ala Ala Gly Lys Ala Ser Gly 
            20                  25                  30          


Glu Ser Glu Glu Ala Ser Pro Ser Leu Thr Ala Glu Glu Arg Glu Ala 
        35                  40                  45              


Leu Gly Gly Leu Asp Ser Arg Leu Phe Gly Phe Val Arg Phe His Glu 
    50                  55                  60                  


Asp Gly Ala Arg Thr Lys Ala Leu Leu Gly Lys Ala Val Arg Cys Tyr 
65                  70                  75                  80  


Glu Ser Leu Ile Leu Lys Ala Glu Gly Lys Val Glu Ser Asp Phe Phe 
                85                  90                  95      


Cys Gln Leu Gly His Phe Asn Leu Leu Leu Glu Asp Tyr Pro Lys Ala 
            100                 105                 110         


Leu Ser Ala Tyr Gln Arg Tyr Tyr Ser Leu Gln Ser Asp Tyr Trp Lys 
        115                 120                 125             


Asn Ala Ala Phe Leu Tyr Gly Leu Gly Leu Val Tyr Phe His Tyr Asn 
    130                 135                 140                 


Ala Phe Gln Trp Ala Ile Lys Ala Phe Gln Glu Val Leu Tyr Val Asp 
145                 150                 155                 160 


Pro Ser Phe Cys Arg Ala Lys Glu Ile His Leu Arg Leu Gly Leu Met 
                165                 170                 175     


Phe Lys Val Asn Thr Asp Tyr Glu Ser Ser Leu Lys His Phe Gln Leu 
            180                 185                 190         


Ala Leu Val Asp Cys Asn Pro Cys Thr Leu Ser Asn Ala Glu Ile Gln 
        195                 200                 205             


Phe His Ile Ala His Leu Tyr Glu Thr Gln Arg Lys Tyr His Ser Ala 
    210                 215                 220                 


Lys Glu Ala Tyr Glu Gln Leu Leu Gln Thr Glu Asn Leu Ser Ala Gln 
225                 230                 235                 240 


Val Lys Ala Thr Val Leu Gln Gln Leu Gly Trp Met His His Thr Val 
                245                 250                 255     


Asp Leu Leu Gly Asp Lys Ala Thr Lys Glu Ser Tyr Ala Ile Gln Tyr 
            260                 265                 270         


Leu Gln Lys Ser Leu Glu Ala Asp Pro Asn Ser Gly Gln Ser Trp Tyr 
        275                 280                 285             


Phe Leu Gly Arg Cys Tyr Ser Ser Ile Gly Lys Val Gln Asp Ala Phe 
    290                 295                 300                 


Ile Ser Tyr Arg Gln Ser Ile Asp Lys Ser Glu Ala Ser Ala Asp Thr 
305                 310                 315                 320 


Trp Cys Ser Ile Gly Val Leu Tyr Gln Gln Gln Asn Gln Pro Met Asp 
                325                 330                 335     


Ala Leu Gln Ala Tyr Ile Cys Ala Val Gln Leu Asp His Gly His Ala 
            340                 345                 350         


Ala Ala Trp Met Asp Leu Gly Thr Leu Tyr Glu Ser Cys Asn Gln Pro 
        355                 360                 365             


Gln Asp Ala Ile Lys Cys Tyr Leu Asn Ala Thr Arg Ser Lys Ser Cys 
    370                 375                 380                 


Ser Asn Thr Ser Ala Leu Ala Ala Arg Ile Lys Tyr Leu Gln Ala Gln 
385                 390                 395                 400 


Leu Cys Asn Leu Pro Gln Gly Ser Leu Gln Asn Lys Thr Lys Leu Leu 
                405                 410                 415     


Pro Ser Ile Glu Glu Ala Trp Ser Leu Pro Ile Pro Ala Glu Leu Thr 
            420                 425                 430         


Ser Arg Gln Gly Ala Met Asn Thr Ala Gln Gln Asn Thr Ser Asp Asn 
        435                 440                 445             


Trp Ser Gly Gly His Ala Val Ser His Pro Pro Val Gln Gln Gln Ala 
    450                 455                 460                 


His Ser Trp Cys Leu Thr Pro Gln Lys Leu Gln His Leu Glu Gln Leu 
465                 470                 475                 480 


Arg Ala Asn Arg Asn Asn Leu Asn Pro Ala Gln Lys Leu Met Leu Glu 
                485                 490                 495     


Gln Leu Glu Ser Gln Phe Val Leu Met Gln Gln His Gln Met Arg Pro 
            500                 505                 510         


Thr Gly Val Ala Gln Val Arg Ser Thr Gly Ile Pro Asn Gly Pro Thr 
        515                 520                 525             


Ala Asp Ser Ser Leu Pro Thr Asn Ser Val Ser Gly Gln Gln Pro Gln 
    530                 535                 540                 


Leu Ala Leu Thr Arg Val Pro Ser Val Ser Gln Pro Gly Val Arg Pro 
545                 550                 555                 560 


Ala Cys Pro Gly Gln Pro Leu Ala Asn Gly Pro Phe Ser Ala Gly His 
                565                 570                 575     


Val Pro Cys Ser Thr Ser Arg Thr Leu Gly Ser Thr Asp Thr Ile Leu 
            580                 585                 590         


Ile Gly Asn Asn His Ile Thr Gly Ser Gly Ser Asn Gly Asn Val Pro 
        595                 600                 605             


Tyr Leu Gln Arg Asn Ala Leu Thr Leu Pro His Asn Arg Thr Asn Leu 
    610                 615                 620                 


Thr Ser Ser Ala Glu Glu Pro Trp Lys Asn Gln Leu Ser Asn Ser Thr 
625                 630                 635                 640 


Gln Gly Leu His Lys Gly Gln Ser Ser His Ser Ala Gly Pro Asn Gly 
                645                 650                 655     


Glu Arg Pro Leu Ser Ser Thr Gly Pro Ser Gln His Leu Gln Ala Ala 
            660                 665                 670         


Gly Ser Gly Ile Gln Asn Gln Asn Gly His Pro Thr Leu Pro Ser Asn 
        675                 680                 685             


Ser Val Thr Gln Gly Ala Ala Leu Asn His Leu Ser Ser His Thr Ala 
    690                 695                 700                 


Thr Ser Gly Gly Gln Gln Gly Ile Thr Leu Thr Lys Glu Ser Lys Pro 
705                 710                 715                 720 


Ser Gly Asn Ile Leu Thr Val Pro Glu Thr Ser Arg His Thr Gly Glu 
                725                 730                 735     


Thr Pro Asn Ser Thr Ala Ser Val Glu Gly Leu Pro Asn His Val His 
            740                 745                 750         


Gln Met Thr Ala Asp Ala Val Cys Ser Pro Ser His Gly Asp Ser Lys 
        755                 760                 765             


Ser Pro Gly Leu Leu Ser Ser Asp Asn Pro Gln Leu Ser Ala Leu Leu 
    770                 775                 780                 


Met Gly Lys Ala Asn Asn Asn Val Gly Thr Gly Thr Cys Asp Lys Val 
785                 790                 795                 800 


Asn Asn Ile His Pro Ala Val His Thr Lys Thr Asp Asn Ser Val Ala 
                805                 810                 815     


Ser Ser Pro Ser Ser Ala Ile Ser Thr Ala Thr Pro Ser Pro Lys Ser 
            820                 825                 830         


Thr Glu Gln Thr Thr Thr Asn Ser Val Thr Ser Leu Asn Ser Pro His 
        835                 840                 845             


Ser Gly Leu His Thr Ile Asn Gly Glu Gly Met Glu Glu Ser Gln Ser 
    850                 855                 860                 


Pro Met Lys Thr Asp Leu Leu Leu Val Asn His Lys Pro Ser Pro Gln 
865                 870                 875                 880 


Ile Ile Pro Ser Met Ser Val Ser Ile Tyr Pro Ser Ser Ala Glu Val 
                885                 890                 895     


Leu Lys Ala Cys Arg Asn Leu Gly Lys Asn Gly Leu Ser Asn Ser Ser 
            900                 905                 910         


Ile Leu Leu Asp Lys Cys Pro Pro Pro Arg Pro Pro Ser Ser Pro Tyr 
        915                 920                 925             


Pro Pro Leu Pro Lys Asp Lys Leu Asn Pro Pro Thr Pro Ser Ile Tyr 
    930                 935                 940                 


Leu Glu Asn Lys Arg Asp Ala Phe Phe Pro Pro Leu His Gln Phe Cys 
945                 950                 955                 960 


Thr Asn Pro Asn Asn Pro Val Thr Val Ile Arg Gly Leu Ala Gly Ala 
                965                 970                 975     


Leu Lys Leu Asp Leu Gly Leu Phe Ser Thr Lys Thr Leu Val Glu Ala 
            980                 985                 990         


Asn Asn Glu His Met Val Glu Val  Arg Thr Gln Leu Leu  Gln Pro Ala 
        995                 1000                 1005             


Asp Glu  Asn Trp Asp Pro Thr  Gly Thr Lys Lys Ile  Trp His Cys 
    1010                 1015                 1020             


Glu Ser  Asn Arg Ser His Thr  Thr Ile Ala Lys Tyr  Ala Gln Tyr 
    1025                 1030                 1035             


Gln Ala  Ser Ser Phe Gln Glu  Ser Leu Arg Glu Glu  Asn Glu Lys 
    1040                 1045                 1050             


Arg Ser  His His Lys Asp His  Ser Asp Ser Glu Ser  Thr Ser Ser 
    1055                 1060                 1065             


Asp Asn  Ser Gly Arg Arg Arg  Lys Gly Pro Phe Lys  Thr Ile Lys 
    1070                 1075                 1080             


Phe Gly  Thr Asn Ile Asp Leu  Ser Asp Asp Lys Lys  Trp Lys Leu 
    1085                 1090                 1095             


Gln Leu  His Glu Leu Thr Lys  Leu Pro Ala Phe Val  Arg Val Val 
    1100                 1105                 1110             


Ser Ala  Gly Asn Leu Leu Ser  His Val Gly His Thr  Ile Leu Gly 
    1115                 1120                 1125             


Met Asn  Thr Val Gln Leu Tyr  Met Lys Val Pro Gly  Ser Arg Thr 
    1130                 1135                 1140             


Pro Gly  His Gln Glu Asn Asn  Asn Phe Cys Ser Val  Asn Ile Asn 
    1145                 1150                 1155             


Ile Gly  Pro Gly Asp Cys Glu  Trp Phe Val Val Pro  Glu Gly Tyr 
    1160                 1165                 1170             


Trp Gly  Val Leu Asn Asp Phe  Cys Glu Lys Asn Asn  Leu Asn Phe 
    1175                 1180                 1185             


Leu Met  Gly Ser Trp Trp Pro  Asn Leu Glu Asp Leu  Tyr Glu Ala 
    1190                 1195                 1200             


Asn Val  Pro Val Tyr Arg Phe  Ile Gln Arg Pro Gly  Asp Leu Val 
    1205                 1210                 1215             


Trp Ile  Asn Ala Gly Thr Val  His Trp Val Gln Ala  Ile Gly Trp 
    1220                 1225                 1230             


Cys Asn  Asn Ile Ala Trp Asn  Val Gly Pro Leu Thr  Ala Cys Gln 
    1235                 1240                 1245             


Tyr Lys  Leu Ala Val Glu Arg  Tyr Glu Trp Asn Lys  Leu Gln Ser 
    1250                 1255                 1260             


Val Lys  Ser Ile Val Pro Met  Val His Leu Ser Trp  Asn Met Ala 
    1265                 1270                 1275             


Arg Asn  Ile Lys Val Ser Asp  Pro Lys Leu Phe Glu  Met Ile Lys 
    1280                 1285                 1290             


Tyr Cys  Leu Leu Arg Thr Leu  Lys Gln Cys Gln Thr  Leu Arg Glu 
    1295                 1300                 1305             


Ala Leu  Ile Ala Ala Gly Lys  Glu Ile Ile Trp His  Gly Arg Thr 
    1310                 1315                 1320             


Lys Glu  Glu Pro Ala His Tyr  Cys Ser Ile Cys Glu  Val Glu Val 
    1325                 1330                 1335             


Phe Asp  Leu Leu Phe Val Thr  Asn Glu Ser Asn Ser  Arg Lys Thr 
    1340                 1345                 1350             


Tyr Ile  Val His Cys Gln Asp  Cys Ala Arg Lys Thr  Ser Gly Asn 
    1355                 1360                 1365             


Leu Glu  Asn Phe Val Val Leu  Glu Gln Tyr Lys Met  Glu Asp Leu 
    1370                 1375                 1380             


Met Gln  Val Tyr Asp Gln Phe  Thr Leu Ala Pro Pro  Leu Pro Ser 
    1385                 1390                 1395             


Ala Ser  Ser 
    1400     


<210>  21
<211>  2450
<212>  DNA
<213>  Homo sapiens

<400>  21
atatttcata cctttctaga aactgggtgt gatctcactg ttggtaaagc ccagcccttc       60

ccaacctgca agctcacctt ccaggactgg gcccagccca tgctctccat atataagctg      120

ctgccccgag cctgattcct agtcctgctt ctcttccctc tctcctccag cctctcacac      180

tctcctcagc tctctcatct cctggaacca tggccagcac atccaccacc atcaggagcc      240

acagcagcag ccgccggggt ttcagtgcca actcagccag gctccctggg gtcagccgct      300

ctggcttcag cagcgtctcc gtgtcccgct ccaggggcag tggtggcctg ggtggtgcat      360

gtggaggagc tggctttggc agccgcagtc tgtatggcct ggggggctcc aagaggatct      420

ccattggagg gggcagctgt gccatcagtg gcggctatgg cagcagagcc ggaggcagct      480

atggctttgg tggcgccggg agtggatttg gtttcggtgg tggagccggc attggctttg      540

gtctgggtgg tggagccggc cttgctggtg gctttggggg ccctggcttc cctgtgtgcc      600

cccctggagg catccaagag gtcaccgtca accagagtct cctgactccc ctcaacctgc      660

aaatcgatcc caccatccag cgggtgcggg ctgaggagcg tgaacagatc aagaccctca      720

acaacaagtt tgcctccttc atcgacaagg tgcggttcct ggagcagcag aacaaggttc      780

tggaaacaaa gtggaccctg ctgcaggagc agggcaccaa gactgtgagg cagaacctgg      840

agccgttgtt cgagcagtac atcaacaacc tcaggaggca gctggacagc attgtcgggg      900

aacggggccg cctggactca gagctcagag gcatgcagga cctggtggag gacttcaaga      960

acaaatatga ggatgaaatc aacaagcgca cagcagcaga gaatgaattt gtgactctga     1020

agaaggatgt ggatgctgcc tacatgaaca aggttgaact gcaagccaag gcagacactc     1080

tcacagacga gatcaacttc ctgagagcct tgtatgatgc agagctgtcc cagatgcaga     1140

cccacatctc agacacatct gtggtgctgt ccatggacaa caaccgcaac ctggacctgg     1200

acagcatcat cgctgaggtc aaggcccaat atgaggagat tgctcagaga agccgggctg     1260

aggctgagtc ctggtaccag accaagtacg aggagctgca ggtcacagca ggcagacatg     1320

gggacgacct gcgcaacacc aagcaggaga ttgctgagat caaccgcatg atccagaggc     1380

tgagatctga gatcgaccac gtcaagaagc agtgcgccaa cctgcaggcc gccattgctg     1440

atgctgagca gcgtggggag atggccctca aggatgccaa gaacaagctg gaagggctgg     1500

aggatgccct gcagaaggcc aagcaggacc tggcccggct gctgaaggag taccaggagc     1560

tgatgaatgt caagctggcc ctggacgtgg agatcgccac ctaccgcaag ctgctggagg     1620

gtgaggagtg caggctgaat ggcgaaggcg ttggacaagt caacatctct gtggtgcagt     1680

ccaccgtctc cagtggctat ggcggtgcca gtggtgtcgg cagtggctta ggcctgggtg     1740

gaggaagcag ctactcctat ggcagtggtc ttggcgttgg aggtggcttc agttccagca     1800

gtggcagagc cattgggggt ggcctcagct ctgttggagg cggcagttcc accatcaagt     1860

acaccaccac ctcctcctcc agcaggaaga gctataagca ctaaagtgcg tctgctagct     1920

ctcggtccca cagtcctcag gcccctctct ggctgcagag ccctctcctc aggttgcctt     1980

tcctctcctg gcctccagtc tcccctgctg tcccaggtag agctgggtat ggatgcttag     2040

tgccctcact tcttctctct ctctctatac catctgagca cccattgctc accatcagat     2100

caacctctga ttttacatca tgatgtaatc accactggag cttcactgtt actaaattat     2160

taatttcttg cctccagtgt tctatctctg aggctgagca ttataagaaa atgacctctg     2220

ctccttttca ttgcagaaaa ttgccagggg cttatttcag aacaacttcc acttactttc     2280

cactggctct caaactctct aacttataag tgttgtgaac ccccacccag gcagtatcca     2340

tgaaagcaca agtgactagt cctatgatgt acaaagcctg tatctctgtg atgatttctg     2400

tgctcttcgc tgtttgcaat tgctaaataa agcagattta taatacaata                2450


<210>  22
<211>  564
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Ser Thr Ser Thr Thr Ile Arg Ser His Ser Ser Ser Arg Arg 
1               5                   10                  15      


Gly Phe Ser Ala Asn Ser Ala Arg Leu Pro Gly Val Ser Arg Ser Gly 
            20                  25                  30          


Phe Ser Ser Val Ser Val Ser Arg Ser Arg Gly Ser Gly Gly Leu Gly 
        35                  40                  45              


Gly Ala Cys Gly Gly Ala Gly Phe Gly Ser Arg Ser Leu Tyr Gly Leu 
    50                  55                  60                  


Gly Gly Ser Lys Arg Ile Ser Ile Gly Gly Gly Ser Cys Ala Ile Ser 
65                  70                  75                  80  


Gly Gly Tyr Gly Ser Arg Ala Gly Gly Ser Tyr Gly Phe Gly Gly Ala 
                85                  90                  95      


Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly Ile Gly Phe Gly Leu 
            100                 105                 110         


Gly Gly Gly Ala Gly Leu Ala Gly Gly Phe Gly Gly Pro Gly Phe Pro 
        115                 120                 125             


Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln Ser Leu 
    130                 135                 140                 


Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Thr Ile Gln Arg Val Arg 
145                 150                 155                 160 


Ala Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser 
                165                 170                 175     


Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Glu 
            180                 185                 190         


Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr Lys Thr Val Arg Gln 
        195                 200                 205             


Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn Asn Leu Arg Arg Gln 
    210                 215                 220                 


Leu Asp Ser Ile Val Gly Glu Arg Gly Arg Leu Asp Ser Glu Leu Arg 
225                 230                 235                 240 


Gly Met Gln Asp Leu Val Glu Asp Phe Lys Asn Lys Tyr Glu Asp Glu 
                245                 250                 255     


Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val Thr Leu Lys Lys 
            260                 265                 270         


Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Gln Ala Lys Ala 
        275                 280                 285             


Asp Thr Leu Thr Asp Glu Ile Asn Phe Leu Arg Ala Leu Tyr Asp Ala 
    290                 295                 300                 


Glu Leu Ser Gln Met Gln Thr His Ile Ser Asp Thr Ser Val Val Leu 
305                 310                 315                 320 


Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu 
                325                 330                 335     


Val Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Arg Ala Glu Ala 
            340                 345                 350         


Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Val Thr Ala Gly 
        355                 360                 365             


Arg His Gly Asp Asp Leu Arg Asn Thr Lys Gln Glu Ile Ala Glu Ile 
    370                 375                 380                 


Asn Arg Met Ile Gln Arg Leu Arg Ser Glu Ile Asp His Val Lys Lys 
385                 390                 395                 400 


Gln Cys Ala Asn Leu Gln Ala Ala Ile Ala Asp Ala Glu Gln Arg Gly 
                405                 410                 415     


Glu Met Ala Leu Lys Asp Ala Lys Asn Lys Leu Glu Gly Leu Glu Asp 
            420                 425                 430         


Ala Leu Gln Lys Ala Lys Gln Asp Leu Ala Arg Leu Leu Lys Glu Tyr 
        435                 440                 445             


Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr 
    450                 455                 460                 


Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Leu Asn Gly Glu Gly 
465                 470                 475                 480 


Val Gly Gln Val Asn Ile Ser Val Val Gln Ser Thr Val Ser Ser Gly 
                485                 490                 495     


Tyr Gly Gly Ala Ser Gly Val Gly Ser Gly Leu Gly Leu Gly Gly Gly 
            500                 505                 510         


Ser Ser Tyr Ser Tyr Gly Ser Gly Leu Gly Val Gly Gly Gly Phe Ser 
        515                 520                 525             


Ser Ser Ser Gly Arg Ala Ile Gly Gly Gly Leu Ser Ser Val Gly Gly 
    530                 535                 540                 


Gly Ser Ser Thr Ile Lys Tyr Thr Thr Thr Ser Ser Ser Ser Arg Lys 
545                 550                 555                 560 


Ser Tyr Lys His 
                


<210>  23
<211>  3687
<212>  DNA
<213>  Homo sapiens

<400>  23
tccaccattt tgctagagaa ggccgcggag gctcagagag gtgcgcacac ttgccctgag       60

tcacacagcg aatgccctcc gcggtcccaa cgcagagaga acgagccgat cggcagcctg      120

agcgaggcag tggttagggg gggccccggc cccggccact cccctcaccc cctccccgca      180

gagcgccgcc caggacaggc tgggccccag gccccgcccc gaggtcctgc ccacacaccc      240

ctgacacacc ggcgtcgcca gccaatggcc ggggtcctat aaacgctacg gtccgcgcgc      300

tctctggcaa gaggcaagag gtagcaacag cgagcgtgcc ggtcgctagt cgcgggtccc      360

cgagtgagca cgccagggag caggagacca aacgacgggg gtcggagtca gagtcgcagt      420

gggagtcccc ggaccggagc acgagcctga gcgggagagc gccgctcgca cgcccgtcgc      480

cacccgcgta cccggcgcag ccagagccac cagcgcagcg ctgccatgga gcccagcagc      540

aagaagctga cgggtcgcct catgctggcc gtgggaggag cagtgcttgg ctccctgcag      600

tttggctaca acactggagt catcaatgcc ccccagaagg tgatcgagga gttctacaac      660

cagacatggg tccaccgcta tggggagagc atcctgccca ccacgctcac cacgctctgg      720

tccctctcag tggccatctt ttctgttggg ggcatgattg gctccttctc tgtgggcctt      780

ttcgttaacc gctttggccg gcggaattca atgctgatga tgaacctgct ggccttcgtg      840

tccgccgtgc tcatgggctt ctcgaaactg ggcaagtcct ttgagatgct gatcctgggc      900

cgcttcatca tcggtgtgta ctgcggcctg accacaggct tcgtgcccat gtatgtgggt      960

gaagtgtcac ccacagccct tcgtggggcc ctgggcaccc tgcaccagct gggcatcgtc     1020

gtcggcatcc tcatcgccca ggtgttcggc ctggactcca tcatgggcaa caaggacctg     1080

tggcccctgc tgctgagcat catcttcatc ccggccctgc tgcagtgcat cgtgctgccc     1140

ttctgccccg agagtccccg cttcctgctc atcaaccgca acgaggagaa ccgggccaag     1200

agtgtgctaa agaagctgcg cgggacagct gacgtgaccc atgacctgca ggagatgaag     1260

gaagagagtc ggcagatgat gcgggagaag aaggtcacca tcctggagct gttccgctcc     1320

cccgcctacc gccagcccat cctcatcgct gtggtgctgc agctgtccca gcagctgtct     1380

ggcatcaacg ctgtcttcta ttactccacg agcatcttcg agaaggcggg ggtgcagcag     1440

cctgtgtatg ccaccattgg ctccggtatc gtcaacacgg ccttcactgt cgtgtcgctg     1500

tttgtggtgg agcgagcagg ccggcggacc ctgcacctca taggcctcgc tggcatggcg     1560

ggttgtgcca tactcatgac catcgcgcta gcactgctgg agcagctacc ctggatgtcc     1620

tatctgagca tcgtggccat ctttggcttt gtggccttct ttgaagtggg tcctggcccc     1680

atcccatggt tcatcgtggc tgaactcttc agccagggtc cacgtccagc tgccattgcc     1740

gttgcaggct tctccaactg gacctcaaat ttcattgtgg gcatgtgctt ccagtatgtg     1800

gagcaactgt gtggtcccta cgtcttcatc atcttcactg tgctcctggt tctgttcttc     1860

atcttcacct acttcaaagt tcctgagact aaaggccgga ccttcgatga gatcgcttcc     1920

ggcttccggc aggggggagc cagccaaagt gacaagacac ccgaggagct gttccatccc     1980

ctgggggctg attcccaagt gtgagtcgcc ccagatcacc agcccggcct gctcccagca     2040

gccctaagga tctctcagga gcacaggcag ctggatgaga cttccaaacc tgacagatgt     2100

cagccgagcc gggcctgggg ctcctttctc cagccagcaa tgatgtccag aagaatattc     2160

aggacttaac ggctccagga ttttaacaaa agcaagactg ttgctcaaat ctattcagac     2220

aagcaacagg ttttataatt tttttattac tgattttgtt atttttatat cagcctgagt     2280

ctcctgtgcc cacatcccag gcttcaccct gaatggttcc atgcctgagg gtggagacta     2340

agccctgtcg agacacttgc cttcttcacc cagctaatct gtagggctgg acctatgtcc     2400

taaggacaca ctaatcgaac tatgaactac aaagcttcta tcccaggagg tggctatggc     2460

cacccgttct gctggcctgg atctccccac tctaggggtc aggctccatt aggatttgcc     2520

ccttcccatc tcttcctacc caaccactca aattaatctt tctttacctg agaccagttg     2580

ggagcactgg agtgcaggga ggagagggga agggccagtc tgggctgccg ggttctagtc     2640

tcctttgcac tgagggccac actattacca tgagaagagg gcctgtggga gcctgcaaac     2700

tcactgctca agaagacatg gagactcctg ccctgttgtg tatagatgca agatatttat     2760

atatattttt ggttgtcaat attaaataca gacactaagt tatagtatat ctggacaagc     2820

caacttgtaa atacaccacc tcactcctgt tacttaccta aacagatata aatggctggt     2880

ttttagaaac atggttttga aatgcttgtg gattgagggt aggaggtttg gatgggagtg     2940

agacagaagt aagtggggtt gcaaccactg caacggctta gacttcgact caggatccag     3000

tcccttacac gtacctctca tcagtgtcct cttgctcaaa aatctgtttg atccctgtta     3060

cccagagaat atatacattc tttatcttga cattcaaggc atttctatca catatttgat     3120

agttggtgtt caaaaaaaca ctagttttgt gccagccgtg atgctcaggc ttgaaatgca     3180

ttattttgaa tgtgaagtaa atactgtacc tttattggac aggctcaaag aggttatgtg     3240

cctgaagtcg cacagtgaat aagctaaaac acctgctttt aacaatggta ccatacaacc     3300

actactccat taactccacc cacctcctgc acccctcccc acacacacaa aatgaaccac     3360

gttctttgta tgggcccaat gagctgtcaa gctgccctgt gttcatttca tttggaattg     3420

ccccctctgg ttcctctgta tactactgct tcatctctaa agacagctca tcctcctcct     3480

tcacccctga atttccagag cacttcatct gctccttcat cacaagtcca gttttctgcc     3540

actagtctga atttcatgag aagatgccga tttggttcct gtgggtcctc agcactattc     3600

agtacagtgc ttgatgcaca gcaggcactc agaaaatact ggaggaaata aaacaccaaa     3660

gatatttgtc aaaaaaaaaa aaaaaaa                                         3687


<210>  24
<211>  492
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Glu Pro Ser Ser Lys Lys Leu Thr Gly Arg Leu Met Leu Ala Val 
1               5                   10                  15      


Gly Gly Ala Val Leu Gly Ser Leu Gln Phe Gly Tyr Asn Thr Gly Val 
            20                  25                  30          


Ile Asn Ala Pro Gln Lys Val Ile Glu Glu Phe Tyr Asn Gln Thr Trp 
        35                  40                  45              


Val His Arg Tyr Gly Glu Ser Ile Leu Pro Thr Thr Leu Thr Thr Leu 
    50                  55                  60                  


Trp Ser Leu Ser Val Ala Ile Phe Ser Val Gly Gly Met Ile Gly Ser 
65                  70                  75                  80  


Phe Ser Val Gly Leu Phe Val Asn Arg Phe Gly Arg Arg Asn Ser Met 
                85                  90                  95      


Leu Met Met Asn Leu Leu Ala Phe Val Ser Ala Val Leu Met Gly Phe 
            100                 105                 110         


Ser Lys Leu Gly Lys Ser Phe Glu Met Leu Ile Leu Gly Arg Phe Ile 
        115                 120                 125             


Ile Gly Val Tyr Cys Gly Leu Thr Thr Gly Phe Val Pro Met Tyr Val 
    130                 135                 140                 


Gly Glu Val Ser Pro Thr Ala Leu Arg Gly Ala Leu Gly Thr Leu His 
145                 150                 155                 160 


Gln Leu Gly Ile Val Val Gly Ile Leu Ile Ala Gln Val Phe Gly Leu 
                165                 170                 175     


Asp Ser Ile Met Gly Asn Lys Asp Leu Trp Pro Leu Leu Leu Ser Ile 
            180                 185                 190         


Ile Phe Ile Pro Ala Leu Leu Gln Cys Ile Val Leu Pro Phe Cys Pro 
        195                 200                 205             


Glu Ser Pro Arg Phe Leu Leu Ile Asn Arg Asn Glu Glu Asn Arg Ala 
    210                 215                 220                 


Lys Ser Val Leu Lys Lys Leu Arg Gly Thr Ala Asp Val Thr His Asp 
225                 230                 235                 240 


Leu Gln Glu Met Lys Glu Glu Ser Arg Gln Met Met Arg Glu Lys Lys 
                245                 250                 255     


Val Thr Ile Leu Glu Leu Phe Arg Ser Pro Ala Tyr Arg Gln Pro Ile 
            260                 265                 270         


Leu Ile Ala Val Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn 
        275                 280                 285             


Ala Val Phe Tyr Tyr Ser Thr Ser Ile Phe Glu Lys Ala Gly Val Gln 
    290                 295                 300                 


Gln Pro Val Tyr Ala Thr Ile Gly Ser Gly Ile Val Asn Thr Ala Phe 
305                 310                 315                 320 


Thr Val Val Ser Leu Phe Val Val Glu Arg Ala Gly Arg Arg Thr Leu 
                325                 330                 335     


His Leu Ile Gly Leu Ala Gly Met Ala Gly Cys Ala Ile Leu Met Thr 
            340                 345                 350         


Ile Ala Leu Ala Leu Leu Glu Gln Leu Pro Trp Met Ser Tyr Leu Ser 
        355                 360                 365             


Ile Val Ala Ile Phe Gly Phe Val Ala Phe Phe Glu Val Gly Pro Gly 
    370                 375                 380                 


Pro Ile Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg 
385                 390                 395                 400 


Pro Ala Ala Ile Ala Val Ala Gly Phe Ser Asn Trp Thr Ser Asn Phe 
                405                 410                 415     


Ile Val Gly Met Cys Phe Gln Tyr Val Glu Gln Leu Cys Gly Pro Tyr 
            420                 425                 430         


Val Phe Ile Ile Phe Thr Val Leu Leu Val Leu Phe Phe Ile Phe Thr 
        435                 440                 445             


Tyr Phe Lys Val Pro Glu Thr Lys Gly Arg Thr Phe Asp Glu Ile Ala 
    450                 455                 460                 


Ser Gly Phe Arg Gln Gly Gly Ala Ser Gln Ser Asp Lys Thr Pro Glu 
465                 470                 475                 480 


Glu Leu Phe His Pro Leu Gly Ala Asp Ser Gln Val 
                485                 490         


<210>  25
<211>  5816
<212>  DNA
<213>  Homo sapiens

<400>  25
attataacag ccaatgcagc cgccatccac gcacaagcaa agaagcatgt cccatttaaa       60

tacacccacg cagccccagc gcccttagcc gatcggggcg ctcagcccac acgcaccgct      120

gctcggggct tggagatccg cgcaggctgg gctcccggac ccggcggacc gacgcgcgga      180

ggatcgggat ccggcgctgt ggggctgggg tgggcggggg aggctgggcc cggggcctct      240

ggcgcgacac ccgcatgagg acgcgagtga aatagaccaa ggtggaattt ccaagggaaa      300

agcttcgggg tggttttggt ccatttctcc agcgaagaag tagacatggc gagcgactcc      360

ccggctcgaa gcctggatga aatagatctc tcggctctga gggaccccgc agggatcttt      420

gaattggtgg aacttgttgg aaatggaaca tacgggcaag tttataaggg tcgtcatgtc      480

aaaacgggcc agcttgcagc catcaaggtt atggatgtca caggggatga agaggaagaa      540

atcaaacaag aaattaacat gttgaagaaa tattctcatc accggaatat tgctacatac      600

tatggtgctt ttatcaaaaa gaacccacca ggcatggatg accaactttg gttggtgatg      660

gagttttgtg gtgctggctc tgtcaccgac ctgatcaaga acacaaaagg taacacgttg      720

aaagaggagt ggattgcata catctgcagg gaaatcttac gggggctgag tcacctgcac      780

cagcataaag tgattcatcg agatattaaa gggcaaaatg tcttgctgac tgaaaatgca      840

gaagttaaac tagtggactt tggagtcagt gctcagcttg atcgaacagt gggcaggagg      900

aatactttca ttggaactcc ctactggatg gcaccagaag ttattgcctg tgatgaaaac      960

ccagatgcca catatgattt caagagtgac ttgtggtctt tgggtatcac cgccattgaa     1020

atggcagaag gtgctccccc tctctgtgac atgcacccca tgagagctct cttcctcatc     1080

ccccggaacc cagcgcctcg gctgaagtct aagaagtggt caaaaaaatt ccagtcattt     1140

attgagagct gcttggtaaa gaatcacagc cagcgaccag caacagaaca attgatgaag     1200

catccattta tacgagacca acctaatgag cgacaggtcc gcattcaact caaggaccat     1260

attgatagaa caaagaagaa gcgaggagaa aaagatgaga cagagtatga gtacagtgga     1320

agtgaggaag aagaggagga gaatgactca ggagagccca gctccatcct gaatctgcca     1380

ggggagtcga cgctgcggag ggactttctg aggctgcagc tggccaacaa ggagcgttct     1440

gaggccctac ggaggcagca gctggagcag cagcagcggg agaatgagga gcacaagcgg     1500

cagctgctgg ccgagcgtca gaagcgcatc gaggagcaga aagagcagag gcggcggctg     1560

gaggagcaac aaaggcgaga gaaggagctg cggaagcagc aggagaggga gcagcgccgg     1620

cactatgagg agcagatgcg ccgggaggag gagaggaggc gtgcggagca tgaacaggaa     1680

tacatcaggc gacagttaga ggaggagcag agacagttag agatcttgca gcagcagcta     1740

ctgcatgaac aagctctact tctggaatat aagcgcaaac aattggaaga acagagacaa     1800

gcagaaagac tgcagaggca gctaaagcaa gaaagagact acttagtttc ccttcagcat     1860

cagcggcagg agcagaggcc tgtggagaag aagccactgt accattacaa agaaggaatg     1920

agtcctagtg agaagccagc atgggccaag gaggtagaag aacggtcaag gctcaaccgg     1980

caaagttccc ctgccatgcc tcacaaggtt gccaacagga tatctgaccc caacctgccc     2040

ccaaggtcgg agtccttcag cattagtgga gttcagcctg ctcgaacacc ccccatgctc     2100

agaccagtcg atccccagat cccacatctg gtagctgtaa aatcccaggg acctgccttg     2160

accgcctccc agtcagtgca cgagcagccc acaaagggcc tctctgggtt tcaggaggct     2220

ctgaacgtga cctcccaccg cgtggagatg ccacgccaga actcagatcc cacctcggaa     2280

aatcctcctc tccccactcg cattgaaaag tttgaccgaa gctcttggtt acgacaggaa     2340

gaagacattc caccaaaggt gcctcaaaga acaacttcta tatccccagc attagccaga     2400

aagaattctc ctgggaatgg tagtgctctg ggacccagac taggatctca acccatcaga     2460

gcaagcaacc ctgatctccg gagaactgag cccatcttgg agagcccctt gcagaggacc     2520

agcagtggca gttcctccag ctccagcacc cctagctccc agcccagctc ccaaggaggc     2580

tcccagcctg gatcacaagc aggatccagt gaacgcacca gagttcgagc caacagtaag     2640

tcagaaggat cacctgtgct cccccatgag cctgccaagg tgaaaccaga agaatccagg     2700

gacattaccc ggcccagtcg accagctagc tacaaaaaag ctatagatga ggatctgacg     2760

gcattagcca aagaactaag agaactccgg attgaagaaa caaaccgccc aatgaagaag     2820

gtgactgatt actcctcctc cagtgaggag tcagaaagta gcgaggaaga ggaggaagat     2880

ggagagagcg agacccatga tgggacagtg gctgtcagcg acatacccag actgatacca     2940

acaggagctc caggcagcaa cgagcagtac aatgtgggaa tggtggggac gcatgggctg     3000

gagacctctc atgcggacag tttcagcggc agtatttcaa gagaaggaac cttgatgatt     3060

agagagacgt ctggagagaa gaagcgatct ggccacagtg acagcaatgg ctttgctggc     3120

cacatcaacc tccctgacct ggtgcagcag agccattctc cagctggaac cccgactgag     3180

ggactggggc gcgtctcaac ccattcccag gagatggact ctgggactga atatggcatg     3240

gggagcagca ccaaagcctc cttcaccccc tttgtggacc ccagagtata ccagacgtct     3300

cccactgatg aagatgaaga ggatgaggaa tcatcagccg cagctctgtt tactagcgaa     3360

cttcttaggc aagaacaggc caaactcaat gaagcaagaa agatttcggt ggtaaatgta     3420

aacccaacca acattcggcc tcatagcgac acaccagaaa tcagaaaata caagaaacga     3480

ttcaactcag aaatactttg tgcagctctg tggggtgtaa accttctggt ggggactgaa     3540

aatggcctga tgcttttgga ccgaagtggg caaggcaaag tctataatct gatcaaccgg     3600

aggcgatttc agcagatgga tgtgctagag ggactgaatg tccttgtgac aatttcagga     3660

aagaagaata agctacgagt ttactatctt tcatggttaa gaaacagaat actacataat     3720

gacccagaag tagaaaagaa acaaggctgg atcactgttg gggacttgga aggctgtata     3780

cattataaag ttgttaaata tgaaaggatc aaatttttgg tgattgcctt aaagaatgct     3840

gtggaaatat atgcttgggc tcctaaaccg tatcataaat tcatggcatt taagtctttt     3900

gcagatctcc agcacaagcc tctgctagtt gatctcacgg tagaagaagg tcaaagatta     3960

aaggttattt ttggttcaca cactggtttc catgtaattg atgttgattc aggaaactct     4020

tatgatatct acataccatc tcatattcag ggcaatatca ctcctcatgc tattgtcatc     4080

ttgcctaaaa cagatggaat ggaaatgctt gtttgctatg aggatgaggg ggtgtatgta     4140

aacacctatg gccggataac taaggatgtg gtgctccaat ggggagaaat gcccacgtct     4200

gtggcctaca ttcattccaa tcagataatg ggctggggcg agaaagctat tgagatccgg     4260

tcagtggaaa caggacattt ggatggagta tttatgcata agcgagctca aaggttaaag     4320

tttctatgtg aaagaaatga taaggtattt tttgcatccg tgcgatctgg aggaagtagc     4380

caagtgtttt tcatgaccct caacagaaat tccatgatga actggtaaca gaagagcact     4440

tggcacttat cttcatggcg ttatttctaa tttaaaagaa cataactcat gtggacttat     4500

gccagtctag aggcagaatc agaaggcttg gttgaacata tcgctttccc tttttcctct     4560

ccctccgccc ctcccagtac agtccatctt tcaatgttgc agcctggttg agaaggagag     4620

aaaaaggtgg caggaatttc caggagatcc ccaagaatgc tgccttgtct gtggacaaag     4680

atggaccatg tgcccttcgg aattagggat agaaacaaat attgtgtgct cttaacgatt     4740

aagctgtgtt atggtgggtt ttcaggtttt tacctttttt ctttacccct ttactctgca     4800

agaatgggga aagaatgcat actgcgaaaa tgagtctttt aaattctgtc tgcctactag     4860

ttttaagtat atggtatgtt gtaaaatttc caatgatgag agacagcaca ataaatgtac     4920

cttatctcct taggctgaag gccataacta catagtggag taatttaaga actctcttgc     4980

cttcaccaac ccaaaaggtt gctttttgat agcaactggc taatgaattt ttaaaaagag     5040

aagaaaaata ctagttttcc cctcttttgg gaaatagatt ttaaatggct aaactactag     5100

ccttaaaact actagtctaa taaaatcaac taccactttt gtgaatctga caggccacat     5160

ttttatatgg ccctttacag aatggagtgt gttgaacagg atactaacgc cattgagttg     5220

agctggccta gcgatggagg gacactctaa cacaactttc cctcagctat tatgcaacag     5280

atcagggaaa aagatgggat gacagatggg gtcagacaga aagagcttct gggaaacaag     5340

cttacatagt cttttttaaa atgcacaaag cctcccagct aagaggtcac ttggtttggg     5400

cttcattagg actgagactt tgttgagttc tttctgggac ttggagagtg gatgatattc     5460

aggctctgaa cattcccagc gctctcccga gggtgccact ttctcaagat gaaaactgtg     5520

actgaaaaaa ttaataataa atgtttctga gctgcctgtg ttctccctgt gtgggtgaga     5580

gaagggacta gactcctaag cctgcctcag atacaagagg catcattggc tccaatttta     5640

gagaacttga aagcaaggct ttggacaaaa ttttgagacc ctaatcactt taccttcctc     5700

caaattaccc aacatacggt aaacaacatt tgtgcagaag tatgtatgta tttagttcag     5760

gttgacttgt gtccttataa actcttactc aaatgatttg aactttaaaa aaaaaa         5816


<210>  26
<211>  1360
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Ser Asp Ser Pro Ala Arg Ser Leu Asp Glu Ile Asp Leu Ser 
1               5                   10                  15      


Ala Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Leu Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Gly Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Gln Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Asn Pro Pro Gly 
                85                  90                  95      


Met Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Val Thr Asp Leu Ile Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Glu 
        115                 120                 125             


Trp Ile Ala Tyr Ile Cys Arg Glu Ile Leu Arg Gly Leu Ser His Leu 
    130                 135                 140                 


His Gln His Lys Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala 
                165                 170                 175     


Gln Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro 
            180                 185                 190         


Tyr Trp Met Ala Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala 
        195                 200                 205             


Thr Tyr Asp Phe Lys Ser Asp Leu Trp Ser Leu Gly Ile Thr Ala Ile 
    210                 215                 220                 


Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 
225                 230                 235                 240 


Ala Leu Phe Leu Ile Pro Arg Asn Pro Ala Pro Arg Leu Lys Ser Lys 
                245                 250                 255     


Lys Trp Ser Lys Lys Phe Gln Ser Phe Ile Glu Ser Cys Leu Val Lys 
            260                 265                 270         


Asn His Ser Gln Arg Pro Ala Thr Glu Gln Leu Met Lys His Pro Phe 
        275                 280                 285             


Ile Arg Asp Gln Pro Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp 
    290                 295                 300                 


His Ile Asp Arg Thr Lys Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu 
305                 310                 315                 320 


Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Glu Glu Glu Asn Asp Ser Gly 
                325                 330                 335     


Glu Pro Ser Ser Ile Leu Asn Leu Pro Gly Glu Ser Thr Leu Arg Arg 
            340                 345                 350         


Asp Phe Leu Arg Leu Gln Leu Ala Asn Lys Glu Arg Ser Glu Ala Leu 
        355                 360                 365             


Arg Arg Gln Gln Leu Glu Gln Gln Gln Arg Glu Asn Glu Glu His Lys 
    370                 375                 380                 


Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu Glu Gln Lys Glu 
385                 390                 395                 400 


Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu Lys Glu Leu Arg 
                405                 410                 415     


Lys Gln Gln Glu Arg Glu Gln Arg Arg His Tyr Glu Glu Gln Met Arg 
            420                 425                 430         


Arg Glu Glu Glu Arg Arg Arg Ala Glu His Glu Gln Glu Tyr Ile Arg 
        435                 440                 445             


Arg Gln Leu Glu Glu Glu Gln Arg Gln Leu Glu Ile Leu Gln Gln Gln 
    450                 455                 460                 


Leu Leu His Glu Gln Ala Leu Leu Leu Glu Tyr Lys Arg Lys Gln Leu 
465                 470                 475                 480 


Glu Glu Gln Arg Gln Ala Glu Arg Leu Gln Arg Gln Leu Lys Gln Glu 
                485                 490                 495     


Arg Asp Tyr Leu Val Ser Leu Gln His Gln Arg Gln Glu Gln Arg Pro 
            500                 505                 510         


Val Glu Lys Lys Pro Leu Tyr His Tyr Lys Glu Gly Met Ser Pro Ser 
        515                 520                 525             


Glu Lys Pro Ala Trp Ala Lys Glu Val Glu Glu Arg Ser Arg Leu Asn 
    530                 535                 540                 


Arg Gln Ser Ser Pro Ala Met Pro His Lys Val Ala Asn Arg Ile Ser 
545                 550                 555                 560 


Asp Pro Asn Leu Pro Pro Arg Ser Glu Ser Phe Ser Ile Ser Gly Val 
                565                 570                 575     


Gln Pro Ala Arg Thr Pro Pro Met Leu Arg Pro Val Asp Pro Gln Ile 
            580                 585                 590         


Pro His Leu Val Ala Val Lys Ser Gln Gly Pro Ala Leu Thr Ala Ser 
        595                 600                 605             


Gln Ser Val His Glu Gln Pro Thr Lys Gly Leu Ser Gly Phe Gln Glu 
    610                 615                 620                 


Ala Leu Asn Val Thr Ser His Arg Val Glu Met Pro Arg Gln Asn Ser 
625                 630                 635                 640 


Asp Pro Thr Ser Glu Asn Pro Pro Leu Pro Thr Arg Ile Glu Lys Phe 
                645                 650                 655     


Asp Arg Ser Ser Trp Leu Arg Gln Glu Glu Asp Ile Pro Pro Lys Val 
            660                 665                 670         


Pro Gln Arg Thr Thr Ser Ile Ser Pro Ala Leu Ala Arg Lys Asn Ser 
        675                 680                 685             


Pro Gly Asn Gly Ser Ala Leu Gly Pro Arg Leu Gly Ser Gln Pro Ile 
    690                 695                 700                 


Arg Ala Ser Asn Pro Asp Leu Arg Arg Thr Glu Pro Ile Leu Glu Ser 
705                 710                 715                 720 


Pro Leu Gln Arg Thr Ser Ser Gly Ser Ser Ser Ser Ser Ser Thr Pro 
                725                 730                 735     


Ser Ser Gln Pro Ser Ser Gln Gly Gly Ser Gln Pro Gly Ser Gln Ala 
            740                 745                 750         


Gly Ser Ser Glu Arg Thr Arg Val Arg Ala Asn Ser Lys Ser Glu Gly 
        755                 760                 765             


Ser Pro Val Leu Pro His Glu Pro Ala Lys Val Lys Pro Glu Glu Ser 
    770                 775                 780                 


Arg Asp Ile Thr Arg Pro Ser Arg Pro Ala Ser Tyr Lys Lys Ala Ile 
785                 790                 795                 800 


Asp Glu Asp Leu Thr Ala Leu Ala Lys Glu Leu Arg Glu Leu Arg Ile 
                805                 810                 815     


Glu Glu Thr Asn Arg Pro Met Lys Lys Val Thr Asp Tyr Ser Ser Ser 
            820                 825                 830         


Ser Glu Glu Ser Glu Ser Ser Glu Glu Glu Glu Glu Asp Gly Glu Ser 
        835                 840                 845             


Glu Thr His Asp Gly Thr Val Ala Val Ser Asp Ile Pro Arg Leu Ile 
    850                 855                 860                 


Pro Thr Gly Ala Pro Gly Ser Asn Glu Gln Tyr Asn Val Gly Met Val 
865                 870                 875                 880 


Gly Thr His Gly Leu Glu Thr Ser His Ala Asp Ser Phe Ser Gly Ser 
                885                 890                 895     


Ile Ser Arg Glu Gly Thr Leu Met Ile Arg Glu Thr Ser Gly Glu Lys 
            900                 905                 910         


Lys Arg Ser Gly His Ser Asp Ser Asn Gly Phe Ala Gly His Ile Asn 
        915                 920                 925             


Leu Pro Asp Leu Val Gln Gln Ser His Ser Pro Ala Gly Thr Pro Thr 
    930                 935                 940                 


Glu Gly Leu Gly Arg Val Ser Thr His Ser Gln Glu Met Asp Ser Gly 
945                 950                 955                 960 


Thr Glu Tyr Gly Met Gly Ser Ser Thr Lys Ala Ser Phe Thr Pro Phe 
                965                 970                 975     


Val Asp Pro Arg Val Tyr Gln Thr Ser Pro Thr Asp Glu Asp Glu Glu 
            980                 985                 990         


Asp Glu Glu Ser Ser Ala Ala Ala  Leu Phe Thr Ser Glu  Leu Leu Arg 
        995                 1000                 1005             


Gln Glu  Gln Ala Lys Leu Asn  Glu Ala Arg Lys Ile  Ser Val Val 
    1010                 1015                 1020             


Asn Val  Asn Pro Thr Asn Ile  Arg Pro His Ser Asp  Thr Pro Glu 
    1025                 1030                 1035             


Ile Arg  Lys Tyr Lys Lys Arg  Phe Asn Ser Glu Ile  Leu Cys Ala 
    1040                 1045                 1050             


Ala Leu  Trp Gly Val Asn Leu  Leu Val Gly Thr Glu  Asn Gly Leu 
    1055                 1060                 1065             


Met Leu  Leu Asp Arg Ser Gly  Gln Gly Lys Val Tyr  Asn Leu Ile 
    1070                 1075                 1080             


Asn Arg  Arg Arg Phe Gln Gln  Met Asp Val Leu Glu  Gly Leu Asn 
    1085                 1090                 1095             


Val Leu  Val Thr Ile Ser Gly  Lys Lys Asn Lys Leu  Arg Val Tyr 
    1100                 1105                 1110             


Tyr Leu  Ser Trp Leu Arg Asn  Arg Ile Leu His Asn  Asp Pro Glu 
    1115                 1120                 1125             


Val Glu  Lys Lys Gln Gly Trp  Ile Thr Val Gly Asp  Leu Glu Gly 
    1130                 1135                 1140             


Cys Ile  His Tyr Lys Val Val  Lys Tyr Glu Arg Ile  Lys Phe Leu 
    1145                 1150                 1155             


Val Ile  Ala Leu Lys Asn Ala  Val Glu Ile Tyr Ala  Trp Ala Pro 
    1160                 1165                 1170             


Lys Pro  Tyr His Lys Phe Met  Ala Phe Lys Ser Phe  Ala Asp Leu 
    1175                 1180                 1185             


Gln His  Lys Pro Leu Leu Val  Asp Leu Thr Val Glu  Glu Gly Gln 
    1190                 1195                 1200             


Arg Leu  Lys Val Ile Phe Gly  Ser His Thr Gly Phe  His Val Ile 
    1205                 1210                 1215             


Asp Val  Asp Ser Gly Asn Ser  Tyr Asp Ile Tyr Ile  Pro Ser His 
    1220                 1225                 1230             


Ile Gln  Gly Asn Ile Thr Pro  His Ala Ile Val Ile  Leu Pro Lys 
    1235                 1240                 1245             


Thr Asp  Gly Met Glu Met Leu  Val Cys Tyr Glu Asp  Glu Gly Val 
    1250                 1255                 1260             


Tyr Val  Asn Thr Tyr Gly Arg  Ile Thr Lys Asp Val  Val Leu Gln 
    1265                 1270                 1275             


Trp Gly  Glu Met Pro Thr Ser  Val Ala Tyr Ile His  Ser Asn Gln 
    1280                 1285                 1290             


Ile Met  Gly Trp Gly Glu Lys  Ala Ile Glu Ile Arg  Ser Val Glu 
    1295                 1300                 1305             


Thr Gly  His Leu Asp Gly Val  Phe Met His Lys Arg  Ala Gln Arg 
    1310                 1315                 1320             


Leu Lys  Phe Leu Cys Glu Arg  Asn Asp Lys Val Phe  Phe Ala Ser 
    1325                 1330                 1335             


Val Arg  Ser Gly Gly Ser Ser  Gln Val Phe Phe Met  Thr Leu Asn 
    1340                 1345                 1350             


Arg Asn  Ser Met Met Asn Trp  
    1355                 1360 


<210>  27
<211>  5792
<212>  DNA
<213>  Homo sapiens

<400>  27
attataacag ccaatgcagc cgccatccac gcacaagcaa agaagcatgt cccatttaaa       60

tacacccacg cagccccagc gcccttagcc gatcggggcg ctcagcccac acgcaccgct      120

gctcggggct tggagatccg cgcaggctgg gctcccggac ccggcggacc gacgcgcgga      180

ggatcgggat ccggcgctgt ggggctgggg tgggcggggg aggctgggcc cggggcctct      240

ggcgcgacac ccgcatgagg acgcgagtga aatagaccaa ggtggaattt ccaagggaaa      300

agcttcgggg tggttttggt ccatttctcc agcgaagaag tagacatggc gagcgactcc      360

ccggctcgaa gcctggatga aatagatctc tcggctctga gggaccccgc agggatcttt      420

gaattggtgg aacttgttgg aaatggaaca tacgggcaag tttataaggg tcgtcatgtc      480

aaaacgggcc agcttgcagc catcaaggtt atggatgtca caggggatga agaggaagaa      540

atcaaacaag aaattaacat gttgaagaaa tattctcatc accggaatat tgctacatac      600

tatggtgctt ttatcaaaaa gaacccacca ggcatggatg accaactttg gttggtgatg      660

gagttttgtg gtgctggctc tgtcaccgac ctgatcaaga acacaaaagg taacacgttg      720

aaagaggagt ggattgcata catctgcagg gaaatcttac gggggctgag tcacctgcac      780

cagcataaag tgattcatcg agatattaaa gggcaaaatg tcttgctgac tgaaaatgca      840

gaagttaaac tagtggactt tggagtcagt gctcagcttg atcgaacagt gggcaggagg      900

aatactttca ttggaactcc ctactggatg gcaccagaag ttattgcctg tgatgaaaac      960

ccagatgcca catatgattt caagagtgac ttgtggtctt tgggtatcac cgccattgaa     1020

atggcagaag gtgctccccc tctctgtgac atgcacccca tgagagctct cttcctcatc     1080

ccccggaacc cagcgcctcg gctgaagtct aagaagtggt caaaaaaatt ccagtcattt     1140

attgagagct gcttggtaaa gaatcacagc cagcgaccag caacagaaca attgatgaag     1200

catccattta tacgagacca acctaatgag cgacaggtcc gcattcaact caaggaccat     1260

attgatagaa caaagaagaa gcgaggagaa aaagatgaga cagagtatga gtacagtgga     1320

agtgaggaag aagaggagga gaatgactca ggagagccca gctccatcct gaatctgcca     1380

ggggagtcga cgctgcggag ggactttctg aggctgcagc tggccaacaa ggagcgttct     1440

gaggccctac ggaggcagca gctggagcag cagcagcggg agaatgagga gcacaagcgg     1500

cagctgctgg ccgagcgtca gaagcgcatc gaggagcaga aagagcagag gcggcggctg     1560

gaggagcaac aaaggcgaga gaaggagctg cggaagcagc aggagaggga gcagcgccgg     1620

cactatgagg agcagatgcg ccgggaggag gagaggaggc gtgcggagca tgaacaggaa     1680

tacatcaggc gacagttaga ggaggagcag agacagttag agatcttgca gcagcagcta     1740

ctgcatgaac aagctctact tctggaatat aagcgcaaac aattggaaga acagagacaa     1800

gcagaaagac tgcagaggca gctaaagcaa gaaagagact acttagtttc ccttcagcat     1860

cagcggcagg agcagaggcc tgtggagaag aagccactgt accattacaa agaaggaatg     1920

agtcctagtg agaagccagc atgggccaag gaggtagaag aacggtcaag gctcaaccgg     1980

caaagttccc ctgccatgcc tcacaaggtt gccaacagga tatctgaccc caacctgccc     2040

ccaaggtcgg agtccttcag cattagtgga gttcagcctg ctcgaacacc ccccatgctc     2100

agaccagtcg atccccagat cccacatctg gtagctgtaa aatcccaggg acctgccttg     2160

accgcctccc agtcagtgca cgagcagccc acaaagggcc tctctgggtt tcaggaggct     2220

ctgaacgtga cctcccaccg cgtggagatg ccacgccaga actcagatcc cacctcggaa     2280

aatcctcctc tccccactcg cattgaaaag tttgaccgaa gctcttggtt acgacaggaa     2340

gaagacattc caccaaaggt gcctcaaaga acaacttcta tatccccagc attagccaga     2400

aagaattctc ctgggaatgg tagtgctctg ggacccagac taggatctca acccatcaga     2460

gcaagcaacc ctgatctccg gagaactgag cccatcttgg agagcccctt gcagaggacc     2520

agcagtggca gttcctccag ctccagcacc cctagctccc agcccagctc ccaaggaggc     2580

tcccagcctg gatcacaagc aggatccagt gaacgcacca gagttcgagc caacagtaag     2640

tcagaaggat cacctgtgct cccccatgag cctgccaagg tgaaaccaga agaatccagg     2700

gacattaccc ggcccagtcg accagctgat ctgacggcat tagccaaaga actaagagaa     2760

ctccggattg aagaaacaaa ccgcccaatg aagaaggtga ctgattactc ctcctccagt     2820

gaggagtcag aaagtagcga ggaagaggag gaagatggag agagcgagac ccatgatggg     2880

acagtggctg tcagcgacat acccagactg ataccaacag gagctccagg cagcaacgag     2940

cagtacaatg tgggaatggt ggggacgcat gggctggaga cctctcatgc ggacagtttc     3000

agcggcagta tttcaagaga aggaaccttg atgattagag agacgtctgg agagaagaag     3060

cgatctggcc acagtgacag caatggcttt gctggccaca tcaacctccc tgacctggtg     3120

cagcagagcc attctccagc tggaaccccg actgagggac tggggcgcgt ctcaacccat     3180

tcccaggaga tggactctgg gactgaatat ggcatgggga gcagcaccaa agcctccttc     3240

accccctttg tggaccccag agtataccag acgtctccca ctgatgaaga tgaagaggat     3300

gaggaatcat cagccgcagc tctgtttact agcgaacttc ttaggcaaga acaggccaaa     3360

ctcaatgaag caagaaagat ttcggtggta aatgtaaacc caaccaacat tcggcctcat     3420

agcgacacac cagaaatcag aaaatacaag aaacgattca actcagaaat actttgtgca     3480

gctctgtggg gtgtaaacct tctggtgggg actgaaaatg gcctgatgct tttggaccga     3540

agtgggcaag gcaaagtcta taatctgatc aaccggaggc gatttcagca gatggatgtg     3600

ctagagggac tgaatgtcct tgtgacaatt tcaggaaaga agaataagct acgagtttac     3660

tatctttcat ggttaagaaa cagaatacta cataatgacc cagaagtaga aaagaaacaa     3720

ggctggatca ctgttgggga cttggaaggc tgtatacatt ataaagttgt taaatatgaa     3780

aggatcaaat ttttggtgat tgccttaaag aatgctgtgg aaatatatgc ttgggctcct     3840

aaaccgtatc ataaattcat ggcatttaag tcttttgcag atctccagca caagcctctg     3900

ctagttgatc tcacggtaga agaaggtcaa agattaaagg ttatttttgg ttcacacact     3960

ggtttccatg taattgatgt tgattcagga aactcttatg atatctacat accatctcat     4020

attcagggca atatcactcc tcatgctatt gtcatcttgc ctaaaacaga tggaatggaa     4080

atgcttgttt gctatgagga tgagggggtg tatgtaaaca cctatggccg gataactaag     4140

gatgtggtgc tccaatgggg agaaatgccc acgtctgtgg cctacattca ttccaatcag     4200

ataatgggct ggggcgagaa agctattgag atccggtcag tggaaacagg acatttggat     4260

ggagtattta tgcataagcg agctcaaagg ttaaagtttc tatgtgaaag aaatgataag     4320

gtattttttg catccgtgcg atctggagga agtagccaag tgtttttcat gaccctcaac     4380

agaaattcca tgatgaactg gtaacagaag agcacttggc acttatcttc atggcgttat     4440

ttctaattta aaagaacata actcatgtgg acttatgcca gtctagaggc agaatcagaa     4500

ggcttggttg aacatatcgc tttccctttt tcctctccct ccgcccctcc cagtacagtc     4560

catctttcaa tgttgcagcc tggttgagaa ggagagaaaa aggtggcagg aatttccagg     4620

agatccccaa gaatgctgcc ttgtctgtgg acaaagatgg accatgtgcc cttcggaatt     4680

agggatagaa acaaatattg tgtgctctta acgattaagc tgtgttatgg tgggttttca     4740

ggtttttacc ttttttcttt acccctttac tctgcaagaa tggggaaaga atgcatactg     4800

cgaaaatgag tcttttaaat tctgtctgcc tactagtttt aagtatatgg tatgttgtaa     4860

aatttccaat gatgagagac agcacaataa atgtacctta tctccttagg ctgaaggcca     4920

taactacata gtggagtaat ttaagaactc tcttgccttc accaacccaa aaggttgctt     4980

tttgatagca actggctaat gaatttttaa aaagagaaga aaaatactag ttttcccctc     5040

ttttgggaaa tagattttaa atggctaaac tactagcctt aaaactacta gtctaataaa     5100

atcaactacc acttttgtga atctgacagg ccacattttt atatggccct ttacagaatg     5160

gagtgtgttg aacaggatac taacgccatt gagttgagct ggcctagcga tggagggaca     5220

ctctaacaca actttccctc agctattatg caacagatca gggaaaaaga tgggatgaca     5280

gatggggtca gacagaaaga gcttctggga aacaagctta catagtcttt tttaaaatgc     5340

acaaagcctc ccagctaaga ggtcacttgg tttgggcttc attaggactg agactttgtt     5400

gagttctttc tgggacttgg agagtggatg atattcaggc tctgaacatt cccagcgctc     5460

tcccgagggt gccactttct caagatgaaa actgtgactg aaaaaattaa taataaatgt     5520

ttctgagctg cctgtgttct ccctgtgtgg gtgagagaag ggactagact cctaagcctg     5580

cctcagatac aagaggcatc attggctcca attttagaga acttgaaagc aaggctttgg     5640

acaaaatttt gagaccctaa tcactttacc ttcctccaaa ttacccaaca tacggtaaac     5700

aacatttgtg cagaagtatg tatgtattta gttcaggttg acttgtgtcc ttataaactc     5760

ttactcaaat gatttgaact ttaaaaaaaa aa                                   5792


<210>  28
<211>  1352
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala Ser Asp Ser Pro Ala Arg Ser Leu Asp Glu Ile Asp Leu Ser 
1               5                   10                  15      


Ala Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Leu Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Gly Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Gln Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Asn Pro Pro Gly 
                85                  90                  95      


Met Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Val Thr Asp Leu Ile Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Glu 
        115                 120                 125             


Trp Ile Ala Tyr Ile Cys Arg Glu Ile Leu Arg Gly Leu Ser His Leu 
    130                 135                 140                 


His Gln His Lys Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala 
                165                 170                 175     


Gln Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro 
            180                 185                 190         


Tyr Trp Met Ala Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala 
        195                 200                 205             


Thr Tyr Asp Phe Lys Ser Asp Leu Trp Ser Leu Gly Ile Thr Ala Ile 
    210                 215                 220                 


Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 
225                 230                 235                 240 


Ala Leu Phe Leu Ile Pro Arg Asn Pro Ala Pro Arg Leu Lys Ser Lys 
                245                 250                 255     


Lys Trp Ser Lys Lys Phe Gln Ser Phe Ile Glu Ser Cys Leu Val Lys 
            260                 265                 270         


Asn His Ser Gln Arg Pro Ala Thr Glu Gln Leu Met Lys His Pro Phe 
        275                 280                 285             


Ile Arg Asp Gln Pro Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp 
    290                 295                 300                 


His Ile Asp Arg Thr Lys Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu 
305                 310                 315                 320 


Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Glu Glu Glu Asn Asp Ser Gly 
                325                 330                 335     


Glu Pro Ser Ser Ile Leu Asn Leu Pro Gly Glu Ser Thr Leu Arg Arg 
            340                 345                 350         


Asp Phe Leu Arg Leu Gln Leu Ala Asn Lys Glu Arg Ser Glu Ala Leu 
        355                 360                 365             


Arg Arg Gln Gln Leu Glu Gln Gln Gln Arg Glu Asn Glu Glu His Lys 
    370                 375                 380                 


Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu Glu Gln Lys Glu 
385                 390                 395                 400 


Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu Lys Glu Leu Arg 
                405                 410                 415     


Lys Gln Gln Glu Arg Glu Gln Arg Arg His Tyr Glu Glu Gln Met Arg 
            420                 425                 430         


Arg Glu Glu Glu Arg Arg Arg Ala Glu His Glu Gln Glu Tyr Ile Arg 
        435                 440                 445             


Arg Gln Leu Glu Glu Glu Gln Arg Gln Leu Glu Ile Leu Gln Gln Gln 
    450                 455                 460                 


Leu Leu His Glu Gln Ala Leu Leu Leu Glu Tyr Lys Arg Lys Gln Leu 
465                 470                 475                 480 


Glu Glu Gln Arg Gln Ala Glu Arg Leu Gln Arg Gln Leu Lys Gln Glu 
                485                 490                 495     


Arg Asp Tyr Leu Val Ser Leu Gln His Gln Arg Gln Glu Gln Arg Pro 
            500                 505                 510         


Val Glu Lys Lys Pro Leu Tyr His Tyr Lys Glu Gly Met Ser Pro Ser 
        515                 520                 525             


Glu Lys Pro Ala Trp Ala Lys Glu Val Glu Glu Arg Ser Arg Leu Asn 
    530                 535                 540                 


Arg Gln Ser Ser Pro Ala Met Pro His Lys Val Ala Asn Arg Ile Ser 
545                 550                 555                 560 


Asp Pro Asn Leu Pro Pro Arg Ser Glu Ser Phe Ser Ile Ser Gly Val 
                565                 570                 575     


Gln Pro Ala Arg Thr Pro Pro Met Leu Arg Pro Val Asp Pro Gln Ile 
            580                 585                 590         


Pro His Leu Val Ala Val Lys Ser Gln Gly Pro Ala Leu Thr Ala Ser 
        595                 600                 605             


Gln Ser Val His Glu Gln Pro Thr Lys Gly Leu Ser Gly Phe Gln Glu 
    610                 615                 620                 


Ala Leu Asn Val Thr Ser His Arg Val Glu Met Pro Arg Gln Asn Ser 
625                 630                 635                 640 


Asp Pro Thr Ser Glu Asn Pro Pro Leu Pro Thr Arg Ile Glu Lys Phe 
                645                 650                 655     


Asp Arg Ser Ser Trp Leu Arg Gln Glu Glu Asp Ile Pro Pro Lys Val 
            660                 665                 670         


Pro Gln Arg Thr Thr Ser Ile Ser Pro Ala Leu Ala Arg Lys Asn Ser 
        675                 680                 685             


Pro Gly Asn Gly Ser Ala Leu Gly Pro Arg Leu Gly Ser Gln Pro Ile 
    690                 695                 700                 


Arg Ala Ser Asn Pro Asp Leu Arg Arg Thr Glu Pro Ile Leu Glu Ser 
705                 710                 715                 720 


Pro Leu Gln Arg Thr Ser Ser Gly Ser Ser Ser Ser Ser Ser Thr Pro 
                725                 730                 735     


Ser Ser Gln Pro Ser Ser Gln Gly Gly Ser Gln Pro Gly Ser Gln Ala 
            740                 745                 750         


Gly Ser Ser Glu Arg Thr Arg Val Arg Ala Asn Ser Lys Ser Glu Gly 
        755                 760                 765             


Ser Pro Val Leu Pro His Glu Pro Ala Lys Val Lys Pro Glu Glu Ser 
    770                 775                 780                 


Arg Asp Ile Thr Arg Pro Ser Arg Pro Ala Asp Leu Thr Ala Leu Ala 
785                 790                 795                 800 


Lys Glu Leu Arg Glu Leu Arg Ile Glu Glu Thr Asn Arg Pro Met Lys 
                805                 810                 815     


Lys Val Thr Asp Tyr Ser Ser Ser Ser Glu Glu Ser Glu Ser Ser Glu 
            820                 825                 830         


Glu Glu Glu Glu Asp Gly Glu Ser Glu Thr His Asp Gly Thr Val Ala 
        835                 840                 845             


Val Ser Asp Ile Pro Arg Leu Ile Pro Thr Gly Ala Pro Gly Ser Asn 
    850                 855                 860                 


Glu Gln Tyr Asn Val Gly Met Val Gly Thr His Gly Leu Glu Thr Ser 
865                 870                 875                 880 


His Ala Asp Ser Phe Ser Gly Ser Ile Ser Arg Glu Gly Thr Leu Met 
                885                 890                 895     


Ile Arg Glu Thr Ser Gly Glu Lys Lys Arg Ser Gly His Ser Asp Ser 
            900                 905                 910         


Asn Gly Phe Ala Gly His Ile Asn Leu Pro Asp Leu Val Gln Gln Ser 
        915                 920                 925             


His Ser Pro Ala Gly Thr Pro Thr Glu Gly Leu Gly Arg Val Ser Thr 
    930                 935                 940                 


His Ser Gln Glu Met Asp Ser Gly Thr Glu Tyr Gly Met Gly Ser Ser 
945                 950                 955                 960 


Thr Lys Ala Ser Phe Thr Pro Phe Val Asp Pro Arg Val Tyr Gln Thr 
                965                 970                 975     


Ser Pro Thr Asp Glu Asp Glu Glu Asp Glu Glu Ser Ser Ala Ala Ala 
            980                 985                 990         


Leu Phe Thr Ser Glu Leu Leu Arg  Gln Glu Gln Ala Lys  Leu Asn Glu 
        995                 1000                 1005             


Ala Arg  Lys Ile Ser Val Val  Asn Val Asn Pro Thr  Asn Ile Arg 
    1010                 1015                 1020             


Pro His  Ser Asp Thr Pro Glu  Ile Arg Lys Tyr Lys  Lys Arg Phe 
    1025                 1030                 1035             


Asn Ser  Glu Ile Leu Cys Ala  Ala Leu Trp Gly Val  Asn Leu Leu 
    1040                 1045                 1050             


Val Gly  Thr Glu Asn Gly Leu  Met Leu Leu Asp Arg  Ser Gly Gln 
    1055                 1060                 1065             


Gly Lys  Val Tyr Asn Leu Ile  Asn Arg Arg Arg Phe  Gln Gln Met 
    1070                 1075                 1080             


Asp Val  Leu Glu Gly Leu Asn  Val Leu Val Thr Ile  Ser Gly Lys 
    1085                 1090                 1095             


Lys Asn  Lys Leu Arg Val Tyr  Tyr Leu Ser Trp Leu  Arg Asn Arg 
    1100                 1105                 1110             


Ile Leu  His Asn Asp Pro Glu  Val Glu Lys Lys Gln  Gly Trp Ile 
    1115                 1120                 1125             


Thr Val  Gly Asp Leu Glu Gly  Cys Ile His Tyr Lys  Val Val Lys 
    1130                 1135                 1140             


Tyr Glu  Arg Ile Lys Phe Leu  Val Ile Ala Leu Lys  Asn Ala Val 
    1145                 1150                 1155             


Glu Ile  Tyr Ala Trp Ala Pro  Lys Pro Tyr His Lys  Phe Met Ala 
    1160                 1165                 1170             


Phe Lys  Ser Phe Ala Asp Leu  Gln His Lys Pro Leu  Leu Val Asp 
    1175                 1180                 1185             


Leu Thr  Val Glu Glu Gly Gln  Arg Leu Lys Val Ile  Phe Gly Ser 
    1190                 1195                 1200             


His Thr  Gly Phe His Val Ile  Asp Val Asp Ser Gly  Asn Ser Tyr 
    1205                 1210                 1215             


Asp Ile  Tyr Ile Pro Ser His  Ile Gln Gly Asn Ile  Thr Pro His 
    1220                 1225                 1230             


Ala Ile  Val Ile Leu Pro Lys  Thr Asp Gly Met Glu  Met Leu Val 
    1235                 1240                 1245             


Cys Tyr  Glu Asp Glu Gly Val  Tyr Val Asn Thr Tyr  Gly Arg Ile 
    1250                 1255                 1260             


Thr Lys  Asp Val Val Leu Gln  Trp Gly Glu Met Pro  Thr Ser Val 
    1265                 1270                 1275             


Ala Tyr  Ile His Ser Asn Gln  Ile Met Gly Trp Gly  Glu Lys Ala 
    1280                 1285                 1290             


Ile Glu  Ile Arg Ser Val Glu  Thr Gly His Leu Asp  Gly Val Phe 
    1295                 1300                 1305             


Met His  Lys Arg Ala Gln Arg  Leu Lys Phe Leu Cys  Glu Arg Asn 
    1310                 1315                 1320             


Asp Lys  Val Phe Phe Ala Ser  Val Arg Ser Gly Gly  Ser Ser Gln 
    1325                 1330                 1335             


Val Phe  Phe Met Thr Leu Asn  Arg Asn Ser Met Met  Asn Trp 
    1340                 1345                 1350         


<210>  29
<211>  5729
<212>  DNA
<213>  Homo sapiens

<400>  29
attataacag ccaatgcagc cgccatccac gcacaagcaa agaagcatgt cccatttaaa       60

tacacccacg cagccccagc gcccttagcc gatcggggcg ctcagcccac acgcaccgct      120

gctcggggct tggagatccg cgcaggctgg gctcccggac ccggcggacc gacgcgcgga      180

ggatcgggat ccggcgctgt ggggctgggg tgggcggggg aggctgggcc cggggcctct      240

ggcgcgacac ccgcatgagg acgcgagtga aatagaccaa ggtggaattt ccaagggaaa      300

agcttcgggg tggttttggt ccatttctcc agcgaagaag tagacatggc gagcgactcc      360

ccggctcgaa gcctggatga aatagatctc tcggctctga gggaccccgc agggatcttt      420

gaattggtgg aacttgttgg aaatggaaca tacgggcaag tttataaggg tcgtcatgtc      480

aaaacgggcc agcttgcagc catcaaggtt atggatgtca caggggatga agaggaagaa      540

atcaaacaag aaattaacat gttgaagaaa tattctcatc accggaatat tgctacatac      600

tatggtgctt ttatcaaaaa gaacccacca ggcatggatg accaactttg gttggtgatg      660

gagttttgtg gtgctggctc tgtcaccgac ctgatcaaga acacaaaagg taacacgttg      720

aaagaggagt ggattgcata catctgcagg gaaatcttac gggggctgag tcacctgcac      780

cagcataaag tgattcatcg agatattaaa gggcaaaatg tcttgctgac tgaaaatgca      840

gaagttaaac tagtggactt tggagtcagt gctcagcttg atcgaacagt gggcaggagg      900

aatactttca ttggaactcc ctactggatg gcaccagaag ttattgcctg tgatgaaaac      960

ccagatgcca catatgattt caagagtgac ttgtggtctt tgggtatcac cgccattgaa     1020

atggcagaag gtgctccccc tctctgtgac atgcacccca tgagagctct cttcctcatc     1080

ccccggaacc cagcgcctcg gctgaagtct aagaagtggt caaaaaaatt ccagtcattt     1140

attgagagct gcttggtaaa gaatcacagc cagcgaccag caacagaaca attgatgaag     1200

catccattta tacgagacca acctaatgag cgacaggtcc gcattcaact caaggaccat     1260

attgatagaa caaagaagaa gcgaggagaa aaagatgaga cagagtatga gtacagtgga     1320

agtgaggaag aagaggagga gaatgactca ggagagccca gctccatcct gaatctgcca     1380

ggggagtcga cgctgcggag ggactttctg aggctgcagc tggccaacaa ggagcgttct     1440

gaggccctac ggaggcagca gctggagcag cagcagcggg agaatgagga gcacaagcgg     1500

cagctgctgg ccgagcgtca gaagcgcatc gaggagcaga aagagcagag gcggcggctg     1560

gaggagcaac aaaggcgaga gaaggagctg cggaagcagc aggagaggga gcagcgccgg     1620

cactatgagg agcagatgcg ccgggaggag gagaggaggc gtgcggagca tgaacaggaa     1680

tataagcgca aacaattgga agaacagaga caagcagaaa gactgcagag gcagctaaag     1740

caagaaagag actacttagt ttcccttcag catcagcggc aggagcagag gcctgtggag     1800

aagaagccac tgtaccatta caaagaagga atgagtccta gtgagaagcc agcatgggcc     1860

aaggaggtag aagaacggtc aaggctcaac cggcaaagtt cccctgccat gcctcacaag     1920

gttgccaaca ggatatctga ccccaacctg cccccaaggt cggagtcctt cagcattagt     1980

ggagttcagc ctgctcgaac accccccatg ctcagaccag tcgatcccca gatcccacat     2040

ctggtagctg taaaatccca gggacctgcc ttgaccgcct cccagtcagt gcacgagcag     2100

cccacaaagg gcctctctgg gtttcaggag gctctgaacg tgacctccca ccgcgtggag     2160

atgccacgcc agaactcaga tcccacctcg gaaaatcctc ctctccccac tcgcattgaa     2220

aagtttgacc gaagctcttg gttacgacag gaagaagaca ttccaccaaa ggtgcctcaa     2280

agaacaactt ctatatcccc agcattagcc agaaagaatt ctcctgggaa tggtagtgct     2340

ctgggaccca gactaggatc tcaacccatc agagcaagca accctgatct ccggagaact     2400

gagcccatct tggagagccc cttgcagagg accagcagtg gcagttcctc cagctccagc     2460

acccctagct cccagcccag ctcccaagga ggctcccagc ctggatcaca agcaggatcc     2520

agtgaacgca ccagagttcg agccaacagt aagtcagaag gatcacctgt gctcccccat     2580

gagcctgcca aggtgaaacc agaagaatcc agggacatta cccggcccag tcgaccagct     2640

agctacaaaa aagctataga tgaggatctg acggcattag ccaaagaact aagagaactc     2700

cggattgaag aaacaaaccg cccaatgaag aaggtgactg attactcctc ctccagtgag     2760

gagtcagaaa gtagcgagga agaggaggaa gatggagaga gcgagaccca tgatgggaca     2820

gtggctgtca gcgacatacc cagactgata ccaacaggag ctccaggcag caacgagcag     2880

tacaatgtgg gaatggtggg gacgcatggg ctggagacct ctcatgcgga cagtttcagc     2940

ggcagtattt caagagaagg aaccttgatg attagagaga cgtctggaga gaagaagcga     3000

tctggccaca gtgacagcaa tggctttgct ggccacatca acctccctga cctggtgcag     3060

cagagccatt ctccagctgg aaccccgact gagggactgg ggcgcgtctc aacccattcc     3120

caggagatgg actctgggac tgaatatggc atggggagca gcaccaaagc ctccttcacc     3180

ccctttgtgg accccagagt ataccagacg tctcccactg atgaagatga agaggatgag     3240

gaatcatcag ccgcagctct gtttactagc gaacttctta ggcaagaaca ggccaaactc     3300

aatgaagcaa gaaagatttc ggtggtaaat gtaaacccaa ccaacattcg gcctcatagc     3360

gacacaccag aaatcagaaa atacaagaaa cgattcaact cagaaatact ttgtgcagct     3420

ctgtggggtg taaaccttct ggtggggact gaaaatggcc tgatgctttt ggaccgaagt     3480

gggcaaggca aagtctataa tctgatcaac cggaggcgat ttcagcagat ggatgtgcta     3540

gagggactga atgtccttgt gacaatttca ggaaagaaga ataagctacg agtttactat     3600

ctttcatggt taagaaacag aatactacat aatgacccag aagtagaaaa gaaacaaggc     3660

tggatcactg ttggggactt ggaaggctgt atacattata aagttgttaa atatgaaagg     3720

atcaaatttt tggtgattgc cttaaagaat gctgtggaaa tatatgcttg ggctcctaaa     3780

ccgtatcata aattcatggc atttaagtct tttgcagatc tccagcacaa gcctctgcta     3840

gttgatctca cggtagaaga aggtcaaaga ttaaaggtta tttttggttc acacactggt     3900

ttccatgtaa ttgatgttga ttcaggaaac tcttatgata tctacatacc atctcatatt     3960

cagggcaata tcactcctca tgctattgtc atcttgccta aaacagatgg aatggaaatg     4020

cttgtttgct atgaggatga gggggtgtat gtaaacacct atggccggat aactaaggat     4080

gtggtgctcc aatggggaga aatgcccacg tctgtggcct acattcattc caatcagata     4140

atgggctggg gcgagaaagc tattgagatc cggtcagtgg aaacaggaca tttggatgga     4200

gtatttatgc ataagcgagc tcaaaggtta aagtttctat gtgaaagaaa tgataaggta     4260

ttttttgcat ccgtgcgatc tggaggaagt agccaagtgt ttttcatgac cctcaacaga     4320

aattccatga tgaactggta acagaagagc acttggcact tatcttcatg gcgttatttc     4380

taatttaaaa gaacataact catgtggact tatgccagtc tagaggcaga atcagaaggc     4440

ttggttgaac atatcgcttt ccctttttcc tctccctccg cccctcccag tacagtccat     4500

ctttcaatgt tgcagcctgg ttgagaagga gagaaaaagg tggcaggaat ttccaggaga     4560

tccccaagaa tgctgccttg tctgtggaca aagatggacc atgtgccctt cggaattagg     4620

gatagaaaca aatattgtgt gctcttaacg attaagctgt gttatggtgg gttttcaggt     4680

ttttaccttt tttctttacc cctttactct gcaagaatgg ggaaagaatg catactgcga     4740

aaatgagtct tttaaattct gtctgcctac tagttttaag tatatggtat gttgtaaaat     4800

ttccaatgat gagagacagc acaataaatg taccttatct ccttaggctg aaggccataa     4860

ctacatagtg gagtaattta agaactctct tgccttcacc aacccaaaag gttgcttttt     4920

gatagcaact ggctaatgaa tttttaaaaa gagaagaaaa atactagttt tcccctcttt     4980

tgggaaatag attttaaatg gctaaactac tagccttaaa actactagtc taataaaatc     5040

aactaccact tttgtgaatc tgacaggcca catttttata tggcccttta cagaatggag     5100

tgtgttgaac aggatactaa cgccattgag ttgagctggc ctagcgatgg agggacactc     5160

taacacaact ttccctcagc tattatgcaa cagatcaggg aaaaagatgg gatgacagat     5220

ggggtcagac agaaagagct tctgggaaac aagcttacat agtctttttt aaaatgcaca     5280

aagcctccca gctaagaggt cacttggttt gggcttcatt aggactgaga ctttgttgag     5340

ttctttctgg gacttggaga gtggatgata ttcaggctct gaacattccc agcgctctcc     5400

cgagggtgcc actttctcaa gatgaaaact gtgactgaaa aaattaataa taaatgtttc     5460

tgagctgcct gtgttctccc tgtgtgggtg agagaaggga ctagactcct aagcctgcct     5520

cagatacaag aggcatcatt ggctccaatt ttagagaact tgaaagcaag gctttggaca     5580

aaattttgag accctaatca ctttaccttc ctccaaatta cccaacatac ggtaaacaac     5640

atttgtgcag aagtatgtat gtatttagtt caggttgact tgtgtcctta taaactctta     5700

ctcaaatgat ttgaacttta aaaaaaaaa                                       5729


<210>  30
<211>  1331
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ala Ser Asp Ser Pro Ala Arg Ser Leu Asp Glu Ile Asp Leu Ser 
1               5                   10                  15      


Ala Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Leu Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Gly Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Gln Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Asn Pro Pro Gly 
                85                  90                  95      


Met Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Val Thr Asp Leu Ile Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Glu 
        115                 120                 125             


Trp Ile Ala Tyr Ile Cys Arg Glu Ile Leu Arg Gly Leu Ser His Leu 
    130                 135                 140                 


His Gln His Lys Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala 
                165                 170                 175     


Gln Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro 
            180                 185                 190         


Tyr Trp Met Ala Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala 
        195                 200                 205             


Thr Tyr Asp Phe Lys Ser Asp Leu Trp Ser Leu Gly Ile Thr Ala Ile 
    210                 215                 220                 


Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 
225                 230                 235                 240 


Ala Leu Phe Leu Ile Pro Arg Asn Pro Ala Pro Arg Leu Lys Ser Lys 
                245                 250                 255     


Lys Trp Ser Lys Lys Phe Gln Ser Phe Ile Glu Ser Cys Leu Val Lys 
            260                 265                 270         


Asn His Ser Gln Arg Pro Ala Thr Glu Gln Leu Met Lys His Pro Phe 
        275                 280                 285             


Ile Arg Asp Gln Pro Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp 
    290                 295                 300                 


His Ile Asp Arg Thr Lys Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu 
305                 310                 315                 320 


Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Glu Glu Glu Asn Asp Ser Gly 
                325                 330                 335     


Glu Pro Ser Ser Ile Leu Asn Leu Pro Gly Glu Ser Thr Leu Arg Arg 
            340                 345                 350         


Asp Phe Leu Arg Leu Gln Leu Ala Asn Lys Glu Arg Ser Glu Ala Leu 
        355                 360                 365             


Arg Arg Gln Gln Leu Glu Gln Gln Gln Arg Glu Asn Glu Glu His Lys 
    370                 375                 380                 


Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu Glu Gln Lys Glu 
385                 390                 395                 400 


Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu Lys Glu Leu Arg 
                405                 410                 415     


Lys Gln Gln Glu Arg Glu Gln Arg Arg His Tyr Glu Glu Gln Met Arg 
            420                 425                 430         


Arg Glu Glu Glu Arg Arg Arg Ala Glu His Glu Gln Glu Tyr Lys Arg 
        435                 440                 445             


Lys Gln Leu Glu Glu Gln Arg Gln Ala Glu Arg Leu Gln Arg Gln Leu 
    450                 455                 460                 


Lys Gln Glu Arg Asp Tyr Leu Val Ser Leu Gln His Gln Arg Gln Glu 
465                 470                 475                 480 


Gln Arg Pro Val Glu Lys Lys Pro Leu Tyr His Tyr Lys Glu Gly Met 
                485                 490                 495     


Ser Pro Ser Glu Lys Pro Ala Trp Ala Lys Glu Val Glu Glu Arg Ser 
            500                 505                 510         


Arg Leu Asn Arg Gln Ser Ser Pro Ala Met Pro His Lys Val Ala Asn 
        515                 520                 525             


Arg Ile Ser Asp Pro Asn Leu Pro Pro Arg Ser Glu Ser Phe Ser Ile 
    530                 535                 540                 


Ser Gly Val Gln Pro Ala Arg Thr Pro Pro Met Leu Arg Pro Val Asp 
545                 550                 555                 560 


Pro Gln Ile Pro His Leu Val Ala Val Lys Ser Gln Gly Pro Ala Leu 
                565                 570                 575     


Thr Ala Ser Gln Ser Val His Glu Gln Pro Thr Lys Gly Leu Ser Gly 
            580                 585                 590         


Phe Gln Glu Ala Leu Asn Val Thr Ser His Arg Val Glu Met Pro Arg 
        595                 600                 605             


Gln Asn Ser Asp Pro Thr Ser Glu Asn Pro Pro Leu Pro Thr Arg Ile 
    610                 615                 620                 


Glu Lys Phe Asp Arg Ser Ser Trp Leu Arg Gln Glu Glu Asp Ile Pro 
625                 630                 635                 640 


Pro Lys Val Pro Gln Arg Thr Thr Ser Ile Ser Pro Ala Leu Ala Arg 
                645                 650                 655     


Lys Asn Ser Pro Gly Asn Gly Ser Ala Leu Gly Pro Arg Leu Gly Ser 
            660                 665                 670         


Gln Pro Ile Arg Ala Ser Asn Pro Asp Leu Arg Arg Thr Glu Pro Ile 
        675                 680                 685             


Leu Glu Ser Pro Leu Gln Arg Thr Ser Ser Gly Ser Ser Ser Ser Ser 
    690                 695                 700                 


Ser Thr Pro Ser Ser Gln Pro Ser Ser Gln Gly Gly Ser Gln Pro Gly 
705                 710                 715                 720 


Ser Gln Ala Gly Ser Ser Glu Arg Thr Arg Val Arg Ala Asn Ser Lys 
                725                 730                 735     


Ser Glu Gly Ser Pro Val Leu Pro His Glu Pro Ala Lys Val Lys Pro 
            740                 745                 750         


Glu Glu Ser Arg Asp Ile Thr Arg Pro Ser Arg Pro Ala Ser Tyr Lys 
        755                 760                 765             


Lys Ala Ile Asp Glu Asp Leu Thr Ala Leu Ala Lys Glu Leu Arg Glu 
    770                 775                 780                 


Leu Arg Ile Glu Glu Thr Asn Arg Pro Met Lys Lys Val Thr Asp Tyr 
785                 790                 795                 800 


Ser Ser Ser Ser Glu Glu Ser Glu Ser Ser Glu Glu Glu Glu Glu Asp 
                805                 810                 815     


Gly Glu Ser Glu Thr His Asp Gly Thr Val Ala Val Ser Asp Ile Pro 
            820                 825                 830         


Arg Leu Ile Pro Thr Gly Ala Pro Gly Ser Asn Glu Gln Tyr Asn Val 
        835                 840                 845             


Gly Met Val Gly Thr His Gly Leu Glu Thr Ser His Ala Asp Ser Phe 
    850                 855                 860                 


Ser Gly Ser Ile Ser Arg Glu Gly Thr Leu Met Ile Arg Glu Thr Ser 
865                 870                 875                 880 


Gly Glu Lys Lys Arg Ser Gly His Ser Asp Ser Asn Gly Phe Ala Gly 
                885                 890                 895     


His Ile Asn Leu Pro Asp Leu Val Gln Gln Ser His Ser Pro Ala Gly 
            900                 905                 910         


Thr Pro Thr Glu Gly Leu Gly Arg Val Ser Thr His Ser Gln Glu Met 
        915                 920                 925             


Asp Ser Gly Thr Glu Tyr Gly Met Gly Ser Ser Thr Lys Ala Ser Phe 
    930                 935                 940                 


Thr Pro Phe Val Asp Pro Arg Val Tyr Gln Thr Ser Pro Thr Asp Glu 
945                 950                 955                 960 


Asp Glu Glu Asp Glu Glu Ser Ser Ala Ala Ala Leu Phe Thr Ser Glu 
                965                 970                 975     


Leu Leu Arg Gln Glu Gln Ala Lys Leu Asn Glu Ala Arg Lys Ile Ser 
            980                 985                 990         


Val Val Asn Val Asn Pro Thr Asn  Ile Arg Pro His Ser  Asp Thr Pro 
        995                 1000                 1005             


Glu Ile  Arg Lys Tyr Lys Lys  Arg Phe Asn Ser Glu  Ile Leu Cys 
    1010                 1015                 1020             


Ala Ala  Leu Trp Gly Val Asn  Leu Leu Val Gly Thr  Glu Asn Gly 
    1025                 1030                 1035             


Leu Met  Leu Leu Asp Arg Ser  Gly Gln Gly Lys Val  Tyr Asn Leu 
    1040                 1045                 1050             


Ile Asn  Arg Arg Arg Phe Gln  Gln Met Asp Val Leu  Glu Gly Leu 
    1055                 1060                 1065             


Asn Val  Leu Val Thr Ile Ser  Gly Lys Lys Asn Lys  Leu Arg Val 
    1070                 1075                 1080             


Tyr Tyr  Leu Ser Trp Leu Arg  Asn Arg Ile Leu His  Asn Asp Pro 
    1085                 1090                 1095             


Glu Val  Glu Lys Lys Gln Gly  Trp Ile Thr Val Gly  Asp Leu Glu 
    1100                 1105                 1110             


Gly Cys  Ile His Tyr Lys Val  Val Lys Tyr Glu Arg  Ile Lys Phe 
    1115                 1120                 1125             


Leu Val  Ile Ala Leu Lys Asn  Ala Val Glu Ile Tyr  Ala Trp Ala 
    1130                 1135                 1140             


Pro Lys  Pro Tyr His Lys Phe  Met Ala Phe Lys Ser  Phe Ala Asp 
    1145                 1150                 1155             


Leu Gln  His Lys Pro Leu Leu  Val Asp Leu Thr Val  Glu Glu Gly 
    1160                 1165                 1170             


Gln Arg  Leu Lys Val Ile Phe  Gly Ser His Thr Gly  Phe His Val 
    1175                 1180                 1185             


Ile Asp  Val Asp Ser Gly Asn  Ser Tyr Asp Ile Tyr  Ile Pro Ser 
    1190                 1195                 1200             


His Ile  Gln Gly Asn Ile Thr  Pro His Ala Ile Val  Ile Leu Pro 
    1205                 1210                 1215             


Lys Thr  Asp Gly Met Glu Met  Leu Val Cys Tyr Glu  Asp Glu Gly 
    1220                 1225                 1230             


Val Tyr  Val Asn Thr Tyr Gly  Arg Ile Thr Lys Asp  Val Val Leu 
    1235                 1240                 1245             


Gln Trp  Gly Glu Met Pro Thr  Ser Val Ala Tyr Ile  His Ser Asn 
    1250                 1255                 1260             


Gln Ile  Met Gly Trp Gly Glu  Lys Ala Ile Glu Ile  Arg Ser Val 
    1265                 1270                 1275             


Glu Thr  Gly His Leu Asp Gly  Val Phe Met His Lys  Arg Ala Gln 
    1280                 1285                 1290             


Arg Leu  Lys Phe Leu Cys Glu  Arg Asn Asp Lys Val  Phe Phe Ala 
    1295                 1300                 1305             


Ser Val  Arg Ser Gly Gly Ser  Ser Gln Val Phe Phe  Met Thr Leu 
    1310                 1315                 1320             


Asn Arg  Asn Ser Met Met Asn  Trp 
    1325                 1330     


<210>  31
<211>  5705
<212>  DNA
<213>  Homo sapiens

<400>  31
attataacag ccaatgcagc cgccatccac gcacaagcaa agaagcatgt cccatttaaa       60

tacacccacg cagccccagc gcccttagcc gatcggggcg ctcagcccac acgcaccgct      120

gctcggggct tggagatccg cgcaggctgg gctcccggac ccggcggacc gacgcgcgga      180

ggatcgggat ccggcgctgt ggggctgggg tgggcggggg aggctgggcc cggggcctct      240

ggcgcgacac ccgcatgagg acgcgagtga aatagaccaa ggtggaattt ccaagggaaa      300

agcttcgggg tggttttggt ccatttctcc agcgaagaag tagacatggc gagcgactcc      360

ccggctcgaa gcctggatga aatagatctc tcggctctga gggaccccgc agggatcttt      420

gaattggtgg aacttgttgg aaatggaaca tacgggcaag tttataaggg tcgtcatgtc      480

aaaacgggcc agcttgcagc catcaaggtt atggatgtca caggggatga agaggaagaa      540

atcaaacaag aaattaacat gttgaagaaa tattctcatc accggaatat tgctacatac      600

tatggtgctt ttatcaaaaa gaacccacca ggcatggatg accaactttg gttggtgatg      660

gagttttgtg gtgctggctc tgtcaccgac ctgatcaaga acacaaaagg taacacgttg      720

aaagaggagt ggattgcata catctgcagg gaaatcttac gggggctgag tcacctgcac      780

cagcataaag tgattcatcg agatattaaa gggcaaaatg tcttgctgac tgaaaatgca      840

gaagttaaac tagtggactt tggagtcagt gctcagcttg atcgaacagt gggcaggagg      900

aatactttca ttggaactcc ctactggatg gcaccagaag ttattgcctg tgatgaaaac      960

ccagatgcca catatgattt caagagtgac ttgtggtctt tgggtatcac cgccattgaa     1020

atggcagaag gtgctccccc tctctgtgac atgcacccca tgagagctct cttcctcatc     1080

ccccggaacc cagcgcctcg gctgaagtct aagaagtggt caaaaaaatt ccagtcattt     1140

attgagagct gcttggtaaa gaatcacagc cagcgaccag caacagaaca attgatgaag     1200

catccattta tacgagacca acctaatgag cgacaggtcc gcattcaact caaggaccat     1260

attgatagaa caaagaagaa gcgaggagaa aaagatgaga cagagtatga gtacagtgga     1320

agtgaggaag aagaggagga gaatgactca ggagagccca gctccatcct gaatctgcca     1380

ggggagtcga cgctgcggag ggactttctg aggctgcagc tggccaacaa ggagcgttct     1440

gaggccctac ggaggcagca gctggagcag cagcagcggg agaatgagga gcacaagcgg     1500

cagctgctgg ccgagcgtca gaagcgcatc gaggagcaga aagagcagag gcggcggctg     1560

gaggagcaac aaaggcgaga gaaggagctg cggaagcagc aggagaggga gcagcgccgg     1620

cactatgagg agcagatgcg ccgggaggag gagaggaggc gtgcggagca tgaacaggaa     1680

tataagcgca aacaattgga agaacagaga caagcagaaa gactgcagag gcagctaaag     1740

caagaaagag actacttagt ttcccttcag catcagcggc aggagcagag gcctgtggag     1800

aagaagccac tgtaccatta caaagaagga atgagtccta gtgagaagcc agcatgggcc     1860

aaggaggtag aagaacggtc aaggctcaac cggcaaagtt cccctgccat gcctcacaag     1920

gttgccaaca ggatatctga ccccaacctg cccccaaggt cggagtcctt cagcattagt     1980

ggagttcagc ctgctcgaac accccccatg ctcagaccag tcgatcccca gatcccacat     2040

ctggtagctg taaaatccca gggacctgcc ttgaccgcct cccagtcagt gcacgagcag     2100

cccacaaagg gcctctctgg gtttcaggag gctctgaacg tgacctccca ccgcgtggag     2160

atgccacgcc agaactcaga tcccacctcg gaaaatcctc ctctccccac tcgcattgaa     2220

aagtttgacc gaagctcttg gttacgacag gaagaagaca ttccaccaaa ggtgcctcaa     2280

agaacaactt ctatatcccc agcattagcc agaaagaatt ctcctgggaa tggtagtgct     2340

ctgggaccca gactaggatc tcaacccatc agagcaagca accctgatct ccggagaact     2400

gagcccatct tggagagccc cttgcagagg accagcagtg gcagttcctc cagctccagc     2460

acccctagct cccagcccag ctcccaagga ggctcccagc ctggatcaca agcaggatcc     2520

agtgaacgca ccagagttcg agccaacagt aagtcagaag gatcacctgt gctcccccat     2580

gagcctgcca aggtgaaacc agaagaatcc agggacatta cccggcccag tcgaccagct     2640

gatctgacgg cattagccaa agaactaaga gaactccgga ttgaagaaac aaaccgccca     2700

atgaagaagg tgactgatta ctcctcctcc agtgaggagt cagaaagtag cgaggaagag     2760

gaggaagatg gagagagcga gacccatgat gggacagtgg ctgtcagcga catacccaga     2820

ctgataccaa caggagctcc aggcagcaac gagcagtaca atgtgggaat ggtggggacg     2880

catgggctgg agacctctca tgcggacagt ttcagcggca gtatttcaag agaaggaacc     2940

ttgatgatta gagagacgtc tggagagaag aagcgatctg gccacagtga cagcaatggc     3000

tttgctggcc acatcaacct ccctgacctg gtgcagcaga gccattctcc agctggaacc     3060

ccgactgagg gactggggcg cgtctcaacc cattcccagg agatggactc tgggactgaa     3120

tatggcatgg ggagcagcac caaagcctcc ttcaccccct ttgtggaccc cagagtatac     3180

cagacgtctc ccactgatga agatgaagag gatgaggaat catcagccgc agctctgttt     3240

actagcgaac ttcttaggca agaacaggcc aaactcaatg aagcaagaaa gatttcggtg     3300

gtaaatgtaa acccaaccaa cattcggcct catagcgaca caccagaaat cagaaaatac     3360

aagaaacgat tcaactcaga aatactttgt gcagctctgt ggggtgtaaa ccttctggtg     3420

gggactgaaa atggcctgat gcttttggac cgaagtgggc aaggcaaagt ctataatctg     3480

atcaaccgga ggcgatttca gcagatggat gtgctagagg gactgaatgt ccttgtgaca     3540

atttcaggaa agaagaataa gctacgagtt tactatcttt catggttaag aaacagaata     3600

ctacataatg acccagaagt agaaaagaaa caaggctgga tcactgttgg ggacttggaa     3660

ggctgtatac attataaagt tgttaaatat gaaaggatca aatttttggt gattgcctta     3720

aagaatgctg tggaaatata tgcttgggct cctaaaccgt atcataaatt catggcattt     3780

aagtcttttg cagatctcca gcacaagcct ctgctagttg atctcacggt agaagaaggt     3840

caaagattaa aggttatttt tggttcacac actggtttcc atgtaattga tgttgattca     3900

ggaaactctt atgatatcta cataccatct catattcagg gcaatatcac tcctcatgct     3960

attgtcatct tgcctaaaac agatggaatg gaaatgcttg tttgctatga ggatgagggg     4020

gtgtatgtaa acacctatgg ccggataact aaggatgtgg tgctccaatg gggagaaatg     4080

cccacgtctg tggcctacat tcattccaat cagataatgg gctggggcga gaaagctatt     4140

gagatccggt cagtggaaac aggacatttg gatggagtat ttatgcataa gcgagctcaa     4200

aggttaaagt ttctatgtga aagaaatgat aaggtatttt ttgcatccgt gcgatctgga     4260

ggaagtagcc aagtgttttt catgaccctc aacagaaatt ccatgatgaa ctggtaacag     4320

aagagcactt ggcacttatc ttcatggcgt tatttctaat ttaaaagaac ataactcatg     4380

tggacttatg ccagtctaga ggcagaatca gaaggcttgg ttgaacatat cgctttccct     4440

ttttcctctc cctccgcccc tcccagtaca gtccatcttt caatgttgca gcctggttga     4500

gaaggagaga aaaaggtggc aggaatttcc aggagatccc caagaatgct gccttgtctg     4560

tggacaaaga tggaccatgt gcccttcgga attagggata gaaacaaata ttgtgtgctc     4620

ttaacgatta agctgtgtta tggtgggttt tcaggttttt accttttttc tttacccctt     4680

tactctgcaa gaatggggaa agaatgcata ctgcgaaaat gagtctttta aattctgtct     4740

gcctactagt tttaagtata tggtatgttg taaaatttcc aatgatgaga gacagcacaa     4800

taaatgtacc ttatctcctt aggctgaagg ccataactac atagtggagt aatttaagaa     4860

ctctcttgcc ttcaccaacc caaaaggttg ctttttgata gcaactggct aatgaatttt     4920

taaaaagaga agaaaaatac tagttttccc ctcttttggg aaatagattt taaatggcta     4980

aactactagc cttaaaacta ctagtctaat aaaatcaact accacttttg tgaatctgac     5040

aggccacatt tttatatggc cctttacaga atggagtgtg ttgaacagga tactaacgcc     5100

attgagttga gctggcctag cgatggaggg acactctaac acaactttcc ctcagctatt     5160

atgcaacaga tcagggaaaa agatgggatg acagatgggg tcagacagaa agagcttctg     5220

ggaaacaagc ttacatagtc ttttttaaaa tgcacaaagc ctcccagcta agaggtcact     5280

tggtttgggc ttcattagga ctgagacttt gttgagttct ttctgggact tggagagtgg     5340

atgatattca ggctctgaac attcccagcg ctctcccgag ggtgccactt tctcaagatg     5400

aaaactgtga ctgaaaaaat taataataaa tgtttctgag ctgcctgtgt tctccctgtg     5460

tgggtgagag aagggactag actcctaagc ctgcctcaga tacaagaggc atcattggct     5520

ccaattttag agaacttgaa agcaaggctt tggacaaaat tttgagaccc taatcacttt     5580

accttcctcc aaattaccca acatacggta aacaacattt gtgcagaagt atgtatgtat     5640

ttagttcagg ttgacttgtg tccttataaa ctcttactca aatgatttga actttaaaaa     5700

aaaaa                                                                 5705


<210>  32
<211>  1323
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Ser Asp Ser Pro Ala Arg Ser Leu Asp Glu Ile Asp Leu Ser 
1               5                   10                  15      


Ala Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Leu Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Gly Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Gln Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Asn Pro Pro Gly 
                85                  90                  95      


Met Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Val Thr Asp Leu Ile Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Glu 
        115                 120                 125             


Trp Ile Ala Tyr Ile Cys Arg Glu Ile Leu Arg Gly Leu Ser His Leu 
    130                 135                 140                 


His Gln His Lys Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala 
                165                 170                 175     


Gln Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro 
            180                 185                 190         


Tyr Trp Met Ala Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala 
        195                 200                 205             


Thr Tyr Asp Phe Lys Ser Asp Leu Trp Ser Leu Gly Ile Thr Ala Ile 
    210                 215                 220                 


Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 
225                 230                 235                 240 


Ala Leu Phe Leu Ile Pro Arg Asn Pro Ala Pro Arg Leu Lys Ser Lys 
                245                 250                 255     


Lys Trp Ser Lys Lys Phe Gln Ser Phe Ile Glu Ser Cys Leu Val Lys 
            260                 265                 270         


Asn His Ser Gln Arg Pro Ala Thr Glu Gln Leu Met Lys His Pro Phe 
        275                 280                 285             


Ile Arg Asp Gln Pro Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp 
    290                 295                 300                 


His Ile Asp Arg Thr Lys Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu 
305                 310                 315                 320 


Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Glu Glu Glu Asn Asp Ser Gly 
                325                 330                 335     


Glu Pro Ser Ser Ile Leu Asn Leu Pro Gly Glu Ser Thr Leu Arg Arg 
            340                 345                 350         


Asp Phe Leu Arg Leu Gln Leu Ala Asn Lys Glu Arg Ser Glu Ala Leu 
        355                 360                 365             


Arg Arg Gln Gln Leu Glu Gln Gln Gln Arg Glu Asn Glu Glu His Lys 
    370                 375                 380                 


Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu Glu Gln Lys Glu 
385                 390                 395                 400 


Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu Lys Glu Leu Arg 
                405                 410                 415     


Lys Gln Gln Glu Arg Glu Gln Arg Arg His Tyr Glu Glu Gln Met Arg 
            420                 425                 430         


Arg Glu Glu Glu Arg Arg Arg Ala Glu His Glu Gln Glu Tyr Lys Arg 
        435                 440                 445             


Lys Gln Leu Glu Glu Gln Arg Gln Ala Glu Arg Leu Gln Arg Gln Leu 
    450                 455                 460                 


Lys Gln Glu Arg Asp Tyr Leu Val Ser Leu Gln His Gln Arg Gln Glu 
465                 470                 475                 480 


Gln Arg Pro Val Glu Lys Lys Pro Leu Tyr His Tyr Lys Glu Gly Met 
                485                 490                 495     


Ser Pro Ser Glu Lys Pro Ala Trp Ala Lys Glu Val Glu Glu Arg Ser 
            500                 505                 510         


Arg Leu Asn Arg Gln Ser Ser Pro Ala Met Pro His Lys Val Ala Asn 
        515                 520                 525             


Arg Ile Ser Asp Pro Asn Leu Pro Pro Arg Ser Glu Ser Phe Ser Ile 
    530                 535                 540                 


Ser Gly Val Gln Pro Ala Arg Thr Pro Pro Met Leu Arg Pro Val Asp 
545                 550                 555                 560 


Pro Gln Ile Pro His Leu Val Ala Val Lys Ser Gln Gly Pro Ala Leu 
                565                 570                 575     


Thr Ala Ser Gln Ser Val His Glu Gln Pro Thr Lys Gly Leu Ser Gly 
            580                 585                 590         


Phe Gln Glu Ala Leu Asn Val Thr Ser His Arg Val Glu Met Pro Arg 
        595                 600                 605             


Gln Asn Ser Asp Pro Thr Ser Glu Asn Pro Pro Leu Pro Thr Arg Ile 
    610                 615                 620                 


Glu Lys Phe Asp Arg Ser Ser Trp Leu Arg Gln Glu Glu Asp Ile Pro 
625                 630                 635                 640 


Pro Lys Val Pro Gln Arg Thr Thr Ser Ile Ser Pro Ala Leu Ala Arg 
                645                 650                 655     


Lys Asn Ser Pro Gly Asn Gly Ser Ala Leu Gly Pro Arg Leu Gly Ser 
            660                 665                 670         


Gln Pro Ile Arg Ala Ser Asn Pro Asp Leu Arg Arg Thr Glu Pro Ile 
        675                 680                 685             


Leu Glu Ser Pro Leu Gln Arg Thr Ser Ser Gly Ser Ser Ser Ser Ser 
    690                 695                 700                 


Ser Thr Pro Ser Ser Gln Pro Ser Ser Gln Gly Gly Ser Gln Pro Gly 
705                 710                 715                 720 


Ser Gln Ala Gly Ser Ser Glu Arg Thr Arg Val Arg Ala Asn Ser Lys 
                725                 730                 735     


Ser Glu Gly Ser Pro Val Leu Pro His Glu Pro Ala Lys Val Lys Pro 
            740                 745                 750         


Glu Glu Ser Arg Asp Ile Thr Arg Pro Ser Arg Pro Ala Asp Leu Thr 
        755                 760                 765             


Ala Leu Ala Lys Glu Leu Arg Glu Leu Arg Ile Glu Glu Thr Asn Arg 
    770                 775                 780                 


Pro Met Lys Lys Val Thr Asp Tyr Ser Ser Ser Ser Glu Glu Ser Glu 
785                 790                 795                 800 


Ser Ser Glu Glu Glu Glu Glu Asp Gly Glu Ser Glu Thr His Asp Gly 
                805                 810                 815     


Thr Val Ala Val Ser Asp Ile Pro Arg Leu Ile Pro Thr Gly Ala Pro 
            820                 825                 830         


Gly Ser Asn Glu Gln Tyr Asn Val Gly Met Val Gly Thr His Gly Leu 
        835                 840                 845             


Glu Thr Ser His Ala Asp Ser Phe Ser Gly Ser Ile Ser Arg Glu Gly 
    850                 855                 860                 


Thr Leu Met Ile Arg Glu Thr Ser Gly Glu Lys Lys Arg Ser Gly His 
865                 870                 875                 880 


Ser Asp Ser Asn Gly Phe Ala Gly His Ile Asn Leu Pro Asp Leu Val 
                885                 890                 895     


Gln Gln Ser His Ser Pro Ala Gly Thr Pro Thr Glu Gly Leu Gly Arg 
            900                 905                 910         


Val Ser Thr His Ser Gln Glu Met Asp Ser Gly Thr Glu Tyr Gly Met 
        915                 920                 925             


Gly Ser Ser Thr Lys Ala Ser Phe Thr Pro Phe Val Asp Pro Arg Val 
    930                 935                 940                 


Tyr Gln Thr Ser Pro Thr Asp Glu Asp Glu Glu Asp Glu Glu Ser Ser 
945                 950                 955                 960 


Ala Ala Ala Leu Phe Thr Ser Glu Leu Leu Arg Gln Glu Gln Ala Lys 
                965                 970                 975     


Leu Asn Glu Ala Arg Lys Ile Ser Val Val Asn Val Asn Pro Thr Asn 
            980                 985                 990         


Ile Arg Pro His Ser Asp Thr Pro  Glu Ile Arg Lys Tyr  Lys Lys Arg 
        995                 1000                 1005             


Phe Asn  Ser Glu Ile Leu Cys  Ala Ala Leu Trp Gly  Val Asn Leu 
    1010                 1015                 1020             


Leu Val  Gly Thr Glu Asn Gly  Leu Met Leu Leu Asp  Arg Ser Gly 
    1025                 1030                 1035             


Gln Gly  Lys Val Tyr Asn Leu  Ile Asn Arg Arg Arg  Phe Gln Gln 
    1040                 1045                 1050             


Met Asp  Val Leu Glu Gly Leu  Asn Val Leu Val Thr  Ile Ser Gly 
    1055                 1060                 1065             


Lys Lys  Asn Lys Leu Arg Val  Tyr Tyr Leu Ser Trp  Leu Arg Asn 
    1070                 1075                 1080             


Arg Ile  Leu His Asn Asp Pro  Glu Val Glu Lys Lys  Gln Gly Trp 
    1085                 1090                 1095             


Ile Thr  Val Gly Asp Leu Glu  Gly Cys Ile His Tyr  Lys Val Val 
    1100                 1105                 1110             


Lys Tyr  Glu Arg Ile Lys Phe  Leu Val Ile Ala Leu  Lys Asn Ala 
    1115                 1120                 1125             


Val Glu  Ile Tyr Ala Trp Ala  Pro Lys Pro Tyr His  Lys Phe Met 
    1130                 1135                 1140             


Ala Phe  Lys Ser Phe Ala Asp  Leu Gln His Lys Pro  Leu Leu Val 
    1145                 1150                 1155             


Asp Leu  Thr Val Glu Glu Gly  Gln Arg Leu Lys Val  Ile Phe Gly 
    1160                 1165                 1170             


Ser His  Thr Gly Phe His Val  Ile Asp Val Asp Ser  Gly Asn Ser 
    1175                 1180                 1185             


Tyr Asp  Ile Tyr Ile Pro Ser  His Ile Gln Gly Asn  Ile Thr Pro 
    1190                 1195                 1200             


His Ala  Ile Val Ile Leu Pro  Lys Thr Asp Gly Met  Glu Met Leu 
    1205                 1210                 1215             


Val Cys  Tyr Glu Asp Glu Gly  Val Tyr Val Asn Thr  Tyr Gly Arg 
    1220                 1225                 1230             


Ile Thr  Lys Asp Val Val Leu  Gln Trp Gly Glu Met  Pro Thr Ser 
    1235                 1240                 1245             


Val Ala  Tyr Ile His Ser Asn  Gln Ile Met Gly Trp  Gly Glu Lys 
    1250                 1255                 1260             


Ala Ile  Glu Ile Arg Ser Val  Glu Thr Gly His Leu  Asp Gly Val 
    1265                 1270                 1275             


Phe Met  His Lys Arg Ala Gln  Arg Leu Lys Phe Leu  Cys Glu Arg 
    1280                 1285                 1290             


Asn Asp  Lys Val Phe Phe Ala  Ser Val Arg Ser Gly  Gly Ser Ser 
    1295                 1300                 1305             


Gln Val  Phe Phe Met Thr Leu  Asn Arg Asn Ser Met  Met Asn Trp 
    1310                 1315                 1320             


<210>  33
<211>  5651
<212>  DNA
<213>  Homo sapiens

<400>  33
attataacag ccaatgcagc cgccatccac gcacaagcaa agaagcatgt cccatttaaa       60

tacacccacg cagccccagc gcccttagcc gatcggggcg ctcagcccac acgcaccgct      120

gctcggggct tggagatccg cgcaggctgg gctcccggac ccggcggacc gacgcgcgga      180

ggatcgggat ccggcgctgt ggggctgggg tgggcggggg aggctgggcc cggggcctct      240

ggcgcgacac ccgcatgagg acgcgagtga aatagaccaa ggtggaattt ccaagggaaa      300

agcttcgggg tggttttggt ccatttctcc agcgaagaag tagacatggc gagcgactcc      360

ccggctcgaa gcctggatga aatagatctc tcggctctga gggaccccgc agggatcttt      420

gaattggtgg aacttgttgg aaatggaaca tacgggcaag tttataaggg tcgtcatgtc      480

aaaacgggcc agcttgcagc catcaaggtt atggatgtca caggggatga agaggaagaa      540

atcaaacaag aaattaacat gttgaagaaa tattctcatc accggaatat tgctacatac      600

tatggtgctt ttatcaaaaa gaacccacca ggcatggatg accaactttg gttggtgatg      660

gagttttgtg gtgctggctc tgtcaccgac ctgatcaaga acacaaaagg taacacgttg      720

aaagaggagt ggattgcata catctgcagg gaaatcttac gggggctgag tcacctgcac      780

cagcataaag tgattcatcg agatattaaa gggcaaaatg tcttgctgac tgaaaatgca      840

gaagttaaac tagtggactt tggagtcagt gctcagcttg atcgaacagt gggcaggagg      900

aatactttca ttggaactcc ctactggatg gcaccagaag ttattgcctg tgatgaaaac      960

ccagatgcca catatgattt caagagtgac ttgtggtctt tgggtatcac cgccattgaa     1020

atggcagaag gtgctccccc tctctgtgac atgcacccca tgagagctct cttcctcatc     1080

ccccggaacc cagcgcctcg gctgaagtct aagaagtggt caaaaaaatt ccagtcattt     1140

attgagagct gcttggtaaa gaatcacagc cagcgaccag caacagaaca attgatgaag     1200

catccattta tacgagacca acctaatgag cgacaggtcc gcattcaact caaggaccat     1260

attgatagaa caaagaagaa gcgaggagaa aaagatgaga cagagtatga gtacagtgga     1320

agtgaggaag aagaggagga gaatgactca ggagagccca gctccatcct gaatctgcca     1380

ggggagtcga cgctgcggag ggactttctg aggctgcagc tggccaacaa ggagcgttct     1440

gaggccctac ggaggcagca gctggagcag cagcagcggg agaatgagga gcacaagcgg     1500

cagctgctgg ccgagcgtca gaagcgcatc gaggagcaga aagagcagag gcggcggctg     1560

gaggagcaac aaaggcgaga gaaggagctg cggaagcagc aggagaggga gcagcgccgg     1620

cactatgagg agcagatgcg ccgggaggag gagaggaggc gtgcggagca tgaacaggaa     1680

tacatcaggc gacagttaga ggaggagcag agacagttag agatcttgca gcagcagcta     1740

ctgcatgaac aagctctact tctggaatat aagcgcaaac aattggaaga acagagacaa     1800

gcagaaagac tgcagaggca gctaaagcaa gaaagagact acttagtttc ccttcagcat     1860

cagcggcagg agcagaggcc tgtggagaag aagccactgt accattacaa agaaggaatg     1920

agtcctagtg agaagccagc atgggccaag gagatcccac atctggtagc tgtaaaatcc     1980

cagggacctg ccttgaccgc ctcccagtca gtgcacgagc agcccacaaa gggcctctct     2040

gggtttcagg aggctctgaa cgtgacctcc caccgcgtgg agatgccacg ccagaactca     2100

gatcccacct cggaaaatcc tcctctcccc actcgcattg aaaagtttga ccgaagctct     2160

tggttacgac aggaagaaga cattccacca aaggtgcctc aaagaacaac ttctatatcc     2220

ccagcattag ccagaaagaa ttctcctggg aatggtagtg ctctgggacc cagactagga     2280

tctcaaccca tcagagcaag caaccctgat ctccggagaa ctgagcccat cttggagagc     2340

cccttgcaga ggaccagcag tggcagttcc tccagctcca gcacccctag ctcccagccc     2400

agctcccaag gaggctccca gcctggatca caagcaggat ccagtgaacg caccagagtt     2460

cgagccaaca gtaagtcaga aggatcacct gtgctccccc atgagcctgc caaggtgaaa     2520

ccagaagaat ccagggacat tacccggccc agtcgaccag ctagctacaa aaaagctata     2580

gatgaggatc tgacggcatt agccaaagaa ctaagagaac tccggattga agaaacaaac     2640

cgcccaatga agaaggtgac tgattactcc tcctccagtg aggagtcaga aagtagcgag     2700

gaagaggagg aagatggaga gagcgagacc catgatggga cagtggctgt cagcgacata     2760

cccagactga taccaacagg agctccaggc agcaacgagc agtacaatgt gggaatggtg     2820

gggacgcatg ggctggagac ctctcatgcg gacagtttca gcggcagtat ttcaagagaa     2880

ggaaccttga tgattagaga gacgtctgga gagaagaagc gatctggcca cagtgacagc     2940

aatggctttg ctggccacat caacctccct gacctggtgc agcagagcca ttctccagct     3000

ggaaccccga ctgagggact ggggcgcgtc tcaacccatt cccaggagat ggactctggg     3060

actgaatatg gcatggggag cagcaccaaa gcctccttca ccccctttgt ggaccccaga     3120

gtataccaga cgtctcccac tgatgaagat gaagaggatg aggaatcatc agccgcagct     3180

ctgtttacta gcgaacttct taggcaagaa caggccaaac tcaatgaagc aagaaagatt     3240

tcggtggtaa atgtaaaccc aaccaacatt cggcctcata gcgacacacc agaaatcaga     3300

aaatacaaga aacgattcaa ctcagaaata ctttgtgcag ctctgtgggg tgtaaacctt     3360

ctggtgggga ctgaaaatgg cctgatgctt ttggaccgaa gtgggcaagg caaagtctat     3420

aatctgatca accggaggcg atttcagcag atggatgtgc tagagggact gaatgtcctt     3480

gtgacaattt caggaaagaa gaataagcta cgagtttact atctttcatg gttaagaaac     3540

agaatactac ataatgaccc agaagtagaa aagaaacaag gctggatcac tgttggggac     3600

ttggaaggct gtatacatta taaagttgtt aaatatgaaa ggatcaaatt tttggtgatt     3660

gccttaaaga atgctgtgga aatatatgct tgggctccta aaccgtatca taaattcatg     3720

gcatttaagt cttttgcaga tctccagcac aagcctctgc tagttgatct cacggtagaa     3780

gaaggtcaaa gattaaaggt tatttttggt tcacacactg gtttccatgt aattgatgtt     3840

gattcaggaa actcttatga tatctacata ccatctcata ttcagggcaa tatcactcct     3900

catgctattg tcatcttgcc taaaacagat ggaatggaaa tgcttgtttg ctatgaggat     3960

gagggggtgt atgtaaacac ctatggccgg ataactaagg atgtggtgct ccaatgggga     4020

gaaatgccca cgtctgtggc ctacattcat tccaatcaga taatgggctg gggcgagaaa     4080

gctattgaga tccggtcagt ggaaacagga catttggatg gagtatttat gcataagcga     4140

gctcaaaggt taaagtttct atgtgaaaga aatgataagg tattttttgc atccgtgcga     4200

tctggaggaa gtagccaagt gtttttcatg accctcaaca gaaattccat gatgaactgg     4260

taacagaaga gcacttggca cttatcttca tggcgttatt tctaatttaa aagaacataa     4320

ctcatgtgga cttatgccag tctagaggca gaatcagaag gcttggttga acatatcgct     4380

ttcccttttt cctctccctc cgcccctccc agtacagtcc atctttcaat gttgcagcct     4440

ggttgagaag gagagaaaaa ggtggcagga atttccagga gatccccaag aatgctgcct     4500

tgtctgtgga caaagatgga ccatgtgccc ttcggaatta gggatagaaa caaatattgt     4560

gtgctcttaa cgattaagct gtgttatggt gggttttcag gtttttacct tttttcttta     4620

cccctttact ctgcaagaat ggggaaagaa tgcatactgc gaaaatgagt cttttaaatt     4680

ctgtctgcct actagtttta agtatatggt atgttgtaaa atttccaatg atgagagaca     4740

gcacaataaa tgtaccttat ctccttaggc tgaaggccat aactacatag tggagtaatt     4800

taagaactct cttgccttca ccaacccaaa aggttgcttt ttgatagcaa ctggctaatg     4860

aatttttaaa aagagaagaa aaatactagt tttcccctct tttgggaaat agattttaaa     4920

tggctaaact actagcctta aaactactag tctaataaaa tcaactacca cttttgtgaa     4980

tctgacaggc cacattttta tatggccctt tacagaatgg agtgtgttga acaggatact     5040

aacgccattg agttgagctg gcctagcgat ggagggacac tctaacacaa ctttccctca     5100

gctattatgc aacagatcag ggaaaaagat gggatgacag atggggtcag acagaaagag     5160

cttctgggaa acaagcttac atagtctttt ttaaaatgca caaagcctcc cagctaagag     5220

gtcacttggt ttgggcttca ttaggactga gactttgttg agttctttct gggacttgga     5280

gagtggatga tattcaggct ctgaacattc ccagcgctct cccgagggtg ccactttctc     5340

aagatgaaaa ctgtgactga aaaaattaat aataaatgtt tctgagctgc ctgtgttctc     5400

cctgtgtggg tgagagaagg gactagactc ctaagcctgc ctcagataca agaggcatca     5460

ttggctccaa ttttagagaa cttgaaagca aggctttgga caaaattttg agaccctaat     5520

cactttacct tcctccaaat tacccaacat acggtaaaca acatttgtgc agaagtatgt     5580

atgtatttag ttcaggttga cttgtgtcct tataaactct tactcaaatg atttgaactt     5640

taaaaaaaaa a                                                          5651


<210>  34
<211>  1305
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Ser Asp Ser Pro Ala Arg Ser Leu Asp Glu Ile Asp Leu Ser 
1               5                   10                  15      


Ala Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Leu Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Gly Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Gln Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Asn Pro Pro Gly 
                85                  90                  95      


Met Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Val Thr Asp Leu Ile Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Glu 
        115                 120                 125             


Trp Ile Ala Tyr Ile Cys Arg Glu Ile Leu Arg Gly Leu Ser His Leu 
    130                 135                 140                 


His Gln His Lys Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala 
                165                 170                 175     


Gln Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro 
            180                 185                 190         


Tyr Trp Met Ala Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala 
        195                 200                 205             


Thr Tyr Asp Phe Lys Ser Asp Leu Trp Ser Leu Gly Ile Thr Ala Ile 
    210                 215                 220                 


Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 
225                 230                 235                 240 


Ala Leu Phe Leu Ile Pro Arg Asn Pro Ala Pro Arg Leu Lys Ser Lys 
                245                 250                 255     


Lys Trp Ser Lys Lys Phe Gln Ser Phe Ile Glu Ser Cys Leu Val Lys 
            260                 265                 270         


Asn His Ser Gln Arg Pro Ala Thr Glu Gln Leu Met Lys His Pro Phe 
        275                 280                 285             


Ile Arg Asp Gln Pro Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp 
    290                 295                 300                 


His Ile Asp Arg Thr Lys Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu 
305                 310                 315                 320 


Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Glu Glu Glu Asn Asp Ser Gly 
                325                 330                 335     


Glu Pro Ser Ser Ile Leu Asn Leu Pro Gly Glu Ser Thr Leu Arg Arg 
            340                 345                 350         


Asp Phe Leu Arg Leu Gln Leu Ala Asn Lys Glu Arg Ser Glu Ala Leu 
        355                 360                 365             


Arg Arg Gln Gln Leu Glu Gln Gln Gln Arg Glu Asn Glu Glu His Lys 
    370                 375                 380                 


Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu Glu Gln Lys Glu 
385                 390                 395                 400 


Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu Lys Glu Leu Arg 
                405                 410                 415     


Lys Gln Gln Glu Arg Glu Gln Arg Arg His Tyr Glu Glu Gln Met Arg 
            420                 425                 430         


Arg Glu Glu Glu Arg Arg Arg Ala Glu His Glu Gln Glu Tyr Ile Arg 
        435                 440                 445             


Arg Gln Leu Glu Glu Glu Gln Arg Gln Leu Glu Ile Leu Gln Gln Gln 
    450                 455                 460                 


Leu Leu His Glu Gln Ala Leu Leu Leu Glu Tyr Lys Arg Lys Gln Leu 
465                 470                 475                 480 


Glu Glu Gln Arg Gln Ala Glu Arg Leu Gln Arg Gln Leu Lys Gln Glu 
                485                 490                 495     


Arg Asp Tyr Leu Val Ser Leu Gln His Gln Arg Gln Glu Gln Arg Pro 
            500                 505                 510         


Val Glu Lys Lys Pro Leu Tyr His Tyr Lys Glu Gly Met Ser Pro Ser 
        515                 520                 525             


Glu Lys Pro Ala Trp Ala Lys Glu Ile Pro His Leu Val Ala Val Lys 
    530                 535                 540                 


Ser Gln Gly Pro Ala Leu Thr Ala Ser Gln Ser Val His Glu Gln Pro 
545                 550                 555                 560 


Thr Lys Gly Leu Ser Gly Phe Gln Glu Ala Leu Asn Val Thr Ser His 
                565                 570                 575     


Arg Val Glu Met Pro Arg Gln Asn Ser Asp Pro Thr Ser Glu Asn Pro 
            580                 585                 590         


Pro Leu Pro Thr Arg Ile Glu Lys Phe Asp Arg Ser Ser Trp Leu Arg 
        595                 600                 605             


Gln Glu Glu Asp Ile Pro Pro Lys Val Pro Gln Arg Thr Thr Ser Ile 
    610                 615                 620                 


Ser Pro Ala Leu Ala Arg Lys Asn Ser Pro Gly Asn Gly Ser Ala Leu 
625                 630                 635                 640 


Gly Pro Arg Leu Gly Ser Gln Pro Ile Arg Ala Ser Asn Pro Asp Leu 
                645                 650                 655     


Arg Arg Thr Glu Pro Ile Leu Glu Ser Pro Leu Gln Arg Thr Ser Ser 
            660                 665                 670         


Gly Ser Ser Ser Ser Ser Ser Thr Pro Ser Ser Gln Pro Ser Ser Gln 
        675                 680                 685             


Gly Gly Ser Gln Pro Gly Ser Gln Ala Gly Ser Ser Glu Arg Thr Arg 
    690                 695                 700                 


Val Arg Ala Asn Ser Lys Ser Glu Gly Ser Pro Val Leu Pro His Glu 
705                 710                 715                 720 


Pro Ala Lys Val Lys Pro Glu Glu Ser Arg Asp Ile Thr Arg Pro Ser 
                725                 730                 735     


Arg Pro Ala Ser Tyr Lys Lys Ala Ile Asp Glu Asp Leu Thr Ala Leu 
            740                 745                 750         


Ala Lys Glu Leu Arg Glu Leu Arg Ile Glu Glu Thr Asn Arg Pro Met 
        755                 760                 765             


Lys Lys Val Thr Asp Tyr Ser Ser Ser Ser Glu Glu Ser Glu Ser Ser 
    770                 775                 780                 


Glu Glu Glu Glu Glu Asp Gly Glu Ser Glu Thr His Asp Gly Thr Val 
785                 790                 795                 800 


Ala Val Ser Asp Ile Pro Arg Leu Ile Pro Thr Gly Ala Pro Gly Ser 
                805                 810                 815     


Asn Glu Gln Tyr Asn Val Gly Met Val Gly Thr His Gly Leu Glu Thr 
            820                 825                 830         


Ser His Ala Asp Ser Phe Ser Gly Ser Ile Ser Arg Glu Gly Thr Leu 
        835                 840                 845             


Met Ile Arg Glu Thr Ser Gly Glu Lys Lys Arg Ser Gly His Ser Asp 
    850                 855                 860                 


Ser Asn Gly Phe Ala Gly His Ile Asn Leu Pro Asp Leu Val Gln Gln 
865                 870                 875                 880 


Ser His Ser Pro Ala Gly Thr Pro Thr Glu Gly Leu Gly Arg Val Ser 
                885                 890                 895     


Thr His Ser Gln Glu Met Asp Ser Gly Thr Glu Tyr Gly Met Gly Ser 
            900                 905                 910         


Ser Thr Lys Ala Ser Phe Thr Pro Phe Val Asp Pro Arg Val Tyr Gln 
        915                 920                 925             


Thr Ser Pro Thr Asp Glu Asp Glu Glu Asp Glu Glu Ser Ser Ala Ala 
    930                 935                 940                 


Ala Leu Phe Thr Ser Glu Leu Leu Arg Gln Glu Gln Ala Lys Leu Asn 
945                 950                 955                 960 


Glu Ala Arg Lys Ile Ser Val Val Asn Val Asn Pro Thr Asn Ile Arg 
                965                 970                 975     


Pro His Ser Asp Thr Pro Glu Ile Arg Lys Tyr Lys Lys Arg Phe Asn 
            980                 985                 990         


Ser Glu Ile Leu Cys Ala Ala Leu  Trp Gly Val Asn Leu  Leu Val Gly 
        995                 1000                 1005             


Thr Glu  Asn Gly Leu Met Leu  Leu Asp Arg Ser Gly  Gln Gly Lys 
    1010                 1015                 1020             


Val Tyr  Asn Leu Ile Asn Arg  Arg Arg Phe Gln Gln  Met Asp Val 
    1025                 1030                 1035             


Leu Glu  Gly Leu Asn Val Leu  Val Thr Ile Ser Gly  Lys Lys Asn 
    1040                 1045                 1050             


Lys Leu  Arg Val Tyr Tyr Leu  Ser Trp Leu Arg Asn  Arg Ile Leu 
    1055                 1060                 1065             


His Asn  Asp Pro Glu Val Glu  Lys Lys Gln Gly Trp  Ile Thr Val 
    1070                 1075                 1080             


Gly Asp  Leu Glu Gly Cys Ile  His Tyr Lys Val Val  Lys Tyr Glu 
    1085                 1090                 1095             


Arg Ile  Lys Phe Leu Val Ile  Ala Leu Lys Asn Ala  Val Glu Ile 
    1100                 1105                 1110             


Tyr Ala  Trp Ala Pro Lys Pro  Tyr His Lys Phe Met  Ala Phe Lys 
    1115                 1120                 1125             


Ser Phe  Ala Asp Leu Gln His  Lys Pro Leu Leu Val  Asp Leu Thr 
    1130                 1135                 1140             


Val Glu  Glu Gly Gln Arg Leu  Lys Val Ile Phe Gly  Ser His Thr 
    1145                 1150                 1155             


Gly Phe  His Val Ile Asp Val  Asp Ser Gly Asn Ser  Tyr Asp Ile 
    1160                 1165                 1170             


Tyr Ile  Pro Ser His Ile Gln  Gly Asn Ile Thr Pro  His Ala Ile 
    1175                 1180                 1185             


Val Ile  Leu Pro Lys Thr Asp  Gly Met Glu Met Leu  Val Cys Tyr 
    1190                 1195                 1200             


Glu Asp  Glu Gly Val Tyr Val  Asn Thr Tyr Gly Arg  Ile Thr Lys 
    1205                 1210                 1215             


Asp Val  Val Leu Gln Trp Gly  Glu Met Pro Thr Ser  Val Ala Tyr 
    1220                 1225                 1230             


Ile His  Ser Asn Gln Ile Met  Gly Trp Gly Glu Lys  Ala Ile Glu 
    1235                 1240                 1245             


Ile Arg  Ser Val Glu Thr Gly  His Leu Asp Gly Val  Phe Met His 
    1250                 1255                 1260             


Lys Arg  Ala Gln Arg Leu Lys  Phe Leu Cys Glu Arg  Asn Asp Lys 
    1265                 1270                 1275             


Val Phe  Phe Ala Ser Val Arg  Ser Gly Gly Ser Ser  Gln Val Phe 
    1280                 1285                 1290             


Phe Met  Thr Leu Asn Arg Asn  Ser Met Met Asn Trp  
    1295                 1300                 1305 


<210>  35
<211>  5627
<212>  DNA
<213>  Homo sapiens

<400>  35
attataacag ccaatgcagc cgccatccac gcacaagcaa agaagcatgt cccatttaaa       60

tacacccacg cagccccagc gcccttagcc gatcggggcg ctcagcccac acgcaccgct      120

gctcggggct tggagatccg cgcaggctgg gctcccggac ccggcggacc gacgcgcgga      180

ggatcgggat ccggcgctgt ggggctgggg tgggcggggg aggctgggcc cggggcctct      240

ggcgcgacac ccgcatgagg acgcgagtga aatagaccaa ggtggaattt ccaagggaaa      300

agcttcgggg tggttttggt ccatttctcc agcgaagaag tagacatggc gagcgactcc      360

ccggctcgaa gcctggatga aatagatctc tcggctctga gggaccccgc agggatcttt      420

gaattggtgg aacttgttgg aaatggaaca tacgggcaag tttataaggg tcgtcatgtc      480

aaaacgggcc agcttgcagc catcaaggtt atggatgtca caggggatga agaggaagaa      540

atcaaacaag aaattaacat gttgaagaaa tattctcatc accggaatat tgctacatac      600

tatggtgctt ttatcaaaaa gaacccacca ggcatggatg accaactttg gttggtgatg      660

gagttttgtg gtgctggctc tgtcaccgac ctgatcaaga acacaaaagg taacacgttg      720

aaagaggagt ggattgcata catctgcagg gaaatcttac gggggctgag tcacctgcac      780

cagcataaag tgattcatcg agatattaaa gggcaaaatg tcttgctgac tgaaaatgca      840

gaagttaaac tagtggactt tggagtcagt gctcagcttg atcgaacagt gggcaggagg      900

aatactttca ttggaactcc ctactggatg gcaccagaag ttattgcctg tgatgaaaac      960

ccagatgcca catatgattt caagagtgac ttgtggtctt tgggtatcac cgccattgaa     1020

atggcagaag gtgctccccc tctctgtgac atgcacccca tgagagctct cttcctcatc     1080

ccccggaacc cagcgcctcg gctgaagtct aagaagtggt caaaaaaatt ccagtcattt     1140

attgagagct gcttggtaaa gaatcacagc cagcgaccag caacagaaca attgatgaag     1200

catccattta tacgagacca acctaatgag cgacaggtcc gcattcaact caaggaccat     1260

attgatagaa caaagaagaa gcgaggagaa aaagatgaga cagagtatga gtacagtgga     1320

agtgaggaag aagaggagga gaatgactca ggagagccca gctccatcct gaatctgcca     1380

ggggagtcga cgctgcggag ggactttctg aggctgcagc tggccaacaa ggagcgttct     1440

gaggccctac ggaggcagca gctggagcag cagcagcggg agaatgagga gcacaagcgg     1500

cagctgctgg ccgagcgtca gaagcgcatc gaggagcaga aagagcagag gcggcggctg     1560

gaggagcaac aaaggcgaga gaaggagctg cggaagcagc aggagaggga gcagcgccgg     1620

cactatgagg agcagatgcg ccgggaggag gagaggaggc gtgcggagca tgaacaggaa     1680

tacatcaggc gacagttaga ggaggagcag agacagttag agatcttgca gcagcagcta     1740

ctgcatgaac aagctctact tctggaatat aagcgcaaac aattggaaga acagagacaa     1800

gcagaaagac tgcagaggca gctaaagcaa gaaagagact acttagtttc ccttcagcat     1860

cagcggcagg agcagaggcc tgtggagaag aagccactgt accattacaa agaaggaatg     1920

agtcctagtg agaagccagc atgggccaag gagatcccac atctggtagc tgtaaaatcc     1980

cagggacctg ccttgaccgc ctcccagtca gtgcacgagc agcccacaaa gggcctctct     2040

gggtttcagg aggctctgaa cgtgacctcc caccgcgtgg agatgccacg ccagaactca     2100

gatcccacct cggaaaatcc tcctctcccc actcgcattg aaaagtttga ccgaagctct     2160

tggttacgac aggaagaaga cattccacca aaggtgcctc aaagaacaac ttctatatcc     2220

ccagcattag ccagaaagaa ttctcctggg aatggtagtg ctctgggacc cagactagga     2280

tctcaaccca tcagagcaag caaccctgat ctccggagaa ctgagcccat cttggagagc     2340

cccttgcaga ggaccagcag tggcagttcc tccagctcca gcacccctag ctcccagccc     2400

agctcccaag gaggctccca gcctggatca caagcaggat ccagtgaacg caccagagtt     2460

cgagccaaca gtaagtcaga aggatcacct gtgctccccc atgagcctgc caaggtgaaa     2520

ccagaagaat ccagggacat tacccggccc agtcgaccag ctgatctgac ggcattagcc     2580

aaagaactaa gagaactccg gattgaagaa acaaaccgcc caatgaagaa ggtgactgat     2640

tactcctcct ccagtgagga gtcagaaagt agcgaggaag aggaggaaga tggagagagc     2700

gagacccatg atgggacagt ggctgtcagc gacataccca gactgatacc aacaggagct     2760

ccaggcagca acgagcagta caatgtggga atggtgggga cgcatgggct ggagacctct     2820

catgcggaca gtttcagcgg cagtatttca agagaaggaa ccttgatgat tagagagacg     2880

tctggagaga agaagcgatc tggccacagt gacagcaatg gctttgctgg ccacatcaac     2940

ctccctgacc tggtgcagca gagccattct ccagctggaa ccccgactga gggactgggg     3000

cgcgtctcaa cccattccca ggagatggac tctgggactg aatatggcat ggggagcagc     3060

accaaagcct ccttcacccc ctttgtggac cccagagtat accagacgtc tcccactgat     3120

gaagatgaag aggatgagga atcatcagcc gcagctctgt ttactagcga acttcttagg     3180

caagaacagg ccaaactcaa tgaagcaaga aagatttcgg tggtaaatgt aaacccaacc     3240

aacattcggc ctcatagcga cacaccagaa atcagaaaat acaagaaacg attcaactca     3300

gaaatacttt gtgcagctct gtggggtgta aaccttctgg tggggactga aaatggcctg     3360

atgcttttgg accgaagtgg gcaaggcaaa gtctataatc tgatcaaccg gaggcgattt     3420

cagcagatgg atgtgctaga gggactgaat gtccttgtga caatttcagg aaagaagaat     3480

aagctacgag tttactatct ttcatggtta agaaacagaa tactacataa tgacccagaa     3540

gtagaaaaga aacaaggctg gatcactgtt ggggacttgg aaggctgtat acattataaa     3600

gttgttaaat atgaaaggat caaatttttg gtgattgcct taaagaatgc tgtggaaata     3660

tatgcttggg ctcctaaacc gtatcataaa ttcatggcat ttaagtcttt tgcagatctc     3720

cagcacaagc ctctgctagt tgatctcacg gtagaagaag gtcaaagatt aaaggttatt     3780

tttggttcac acactggttt ccatgtaatt gatgttgatt caggaaactc ttatgatatc     3840

tacataccat ctcatattca gggcaatatc actcctcatg ctattgtcat cttgcctaaa     3900

acagatggaa tggaaatgct tgtttgctat gaggatgagg gggtgtatgt aaacacctat     3960

ggccggataa ctaaggatgt ggtgctccaa tggggagaaa tgcccacgtc tgtggcctac     4020

attcattcca atcagataat gggctggggc gagaaagcta ttgagatccg gtcagtggaa     4080

acaggacatt tggatggagt atttatgcat aagcgagctc aaaggttaaa gtttctatgt     4140

gaaagaaatg ataaggtatt ttttgcatcc gtgcgatctg gaggaagtag ccaagtgttt     4200

ttcatgaccc tcaacagaaa ttccatgatg aactggtaac agaagagcac ttggcactta     4260

tcttcatggc gttatttcta atttaaaaga acataactca tgtggactta tgccagtcta     4320

gaggcagaat cagaaggctt ggttgaacat atcgctttcc ctttttcctc tccctccgcc     4380

cctcccagta cagtccatct ttcaatgttg cagcctggtt gagaaggaga gaaaaaggtg     4440

gcaggaattt ccaggagatc cccaagaatg ctgccttgtc tgtggacaaa gatggaccat     4500

gtgcccttcg gaattaggga tagaaacaaa tattgtgtgc tcttaacgat taagctgtgt     4560

tatggtgggt tttcaggttt ttaccttttt tctttacccc tttactctgc aagaatgggg     4620

aaagaatgca tactgcgaaa atgagtcttt taaattctgt ctgcctacta gttttaagta     4680

tatggtatgt tgtaaaattt ccaatgatga gagacagcac aataaatgta ccttatctcc     4740

ttaggctgaa ggccataact acatagtgga gtaatttaag aactctcttg ccttcaccaa     4800

cccaaaaggt tgctttttga tagcaactgg ctaatgaatt tttaaaaaga gaagaaaaat     4860

actagttttc ccctcttttg ggaaatagat tttaaatggc taaactacta gccttaaaac     4920

tactagtcta ataaaatcaa ctaccacttt tgtgaatctg acaggccaca tttttatatg     4980

gccctttaca gaatggagtg tgttgaacag gatactaacg ccattgagtt gagctggcct     5040

agcgatggag ggacactcta acacaacttt ccctcagcta ttatgcaaca gatcagggaa     5100

aaagatggga tgacagatgg ggtcagacag aaagagcttc tgggaaacaa gcttacatag     5160

tcttttttaa aatgcacaaa gcctcccagc taagaggtca cttggtttgg gcttcattag     5220

gactgagact ttgttgagtt ctttctggga cttggagagt ggatgatatt caggctctga     5280

acattcccag cgctctcccg agggtgccac tttctcaaga tgaaaactgt gactgaaaaa     5340

attaataata aatgtttctg agctgcctgt gttctccctg tgtgggtgag agaagggact     5400

agactcctaa gcctgcctca gatacaagag gcatcattgg ctccaatttt agagaacttg     5460

aaagcaaggc tttggacaaa attttgagac cctaatcact ttaccttcct ccaaattacc     5520

caacatacgg taaacaacat ttgtgcagaa gtatgtatgt atttagttca ggttgacttg     5580

tgtccttata aactcttact caaatgattt gaactttaaa aaaaaaa                   5627


<210>  36
<211>  1297
<212>  PRT
<213>  Homo sapiens

<400>  36

Met Ala Ser Asp Ser Pro Ala Arg Ser Leu Asp Glu Ile Asp Leu Ser 
1               5                   10                  15      


Ala Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Leu Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Gly Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Gln Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Asn Pro Pro Gly 
                85                  90                  95      


Met Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Val Thr Asp Leu Ile Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Glu 
        115                 120                 125             


Trp Ile Ala Tyr Ile Cys Arg Glu Ile Leu Arg Gly Leu Ser His Leu 
    130                 135                 140                 


His Gln His Lys Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala 
                165                 170                 175     


Gln Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro 
            180                 185                 190         


Tyr Trp Met Ala Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala 
        195                 200                 205             


Thr Tyr Asp Phe Lys Ser Asp Leu Trp Ser Leu Gly Ile Thr Ala Ile 
    210                 215                 220                 


Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 
225                 230                 235                 240 


Ala Leu Phe Leu Ile Pro Arg Asn Pro Ala Pro Arg Leu Lys Ser Lys 
                245                 250                 255     


Lys Trp Ser Lys Lys Phe Gln Ser Phe Ile Glu Ser Cys Leu Val Lys 
            260                 265                 270         


Asn His Ser Gln Arg Pro Ala Thr Glu Gln Leu Met Lys His Pro Phe 
        275                 280                 285             


Ile Arg Asp Gln Pro Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp 
    290                 295                 300                 


His Ile Asp Arg Thr Lys Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu 
305                 310                 315                 320 


Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Glu Glu Glu Asn Asp Ser Gly 
                325                 330                 335     


Glu Pro Ser Ser Ile Leu Asn Leu Pro Gly Glu Ser Thr Leu Arg Arg 
            340                 345                 350         


Asp Phe Leu Arg Leu Gln Leu Ala Asn Lys Glu Arg Ser Glu Ala Leu 
        355                 360                 365             


Arg Arg Gln Gln Leu Glu Gln Gln Gln Arg Glu Asn Glu Glu His Lys 
    370                 375                 380                 


Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu Glu Gln Lys Glu 
385                 390                 395                 400 


Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu Lys Glu Leu Arg 
                405                 410                 415     


Lys Gln Gln Glu Arg Glu Gln Arg Arg His Tyr Glu Glu Gln Met Arg 
            420                 425                 430         


Arg Glu Glu Glu Arg Arg Arg Ala Glu His Glu Gln Glu Tyr Ile Arg 
        435                 440                 445             


Arg Gln Leu Glu Glu Glu Gln Arg Gln Leu Glu Ile Leu Gln Gln Gln 
    450                 455                 460                 


Leu Leu His Glu Gln Ala Leu Leu Leu Glu Tyr Lys Arg Lys Gln Leu 
465                 470                 475                 480 


Glu Glu Gln Arg Gln Ala Glu Arg Leu Gln Arg Gln Leu Lys Gln Glu 
                485                 490                 495     


Arg Asp Tyr Leu Val Ser Leu Gln His Gln Arg Gln Glu Gln Arg Pro 
            500                 505                 510         


Val Glu Lys Lys Pro Leu Tyr His Tyr Lys Glu Gly Met Ser Pro Ser 
        515                 520                 525             


Glu Lys Pro Ala Trp Ala Lys Glu Ile Pro His Leu Val Ala Val Lys 
    530                 535                 540                 


Ser Gln Gly Pro Ala Leu Thr Ala Ser Gln Ser Val His Glu Gln Pro 
545                 550                 555                 560 


Thr Lys Gly Leu Ser Gly Phe Gln Glu Ala Leu Asn Val Thr Ser His 
                565                 570                 575     


Arg Val Glu Met Pro Arg Gln Asn Ser Asp Pro Thr Ser Glu Asn Pro 
            580                 585                 590         


Pro Leu Pro Thr Arg Ile Glu Lys Phe Asp Arg Ser Ser Trp Leu Arg 
        595                 600                 605             


Gln Glu Glu Asp Ile Pro Pro Lys Val Pro Gln Arg Thr Thr Ser Ile 
    610                 615                 620                 


Ser Pro Ala Leu Ala Arg Lys Asn Ser Pro Gly Asn Gly Ser Ala Leu 
625                 630                 635                 640 


Gly Pro Arg Leu Gly Ser Gln Pro Ile Arg Ala Ser Asn Pro Asp Leu 
                645                 650                 655     


Arg Arg Thr Glu Pro Ile Leu Glu Ser Pro Leu Gln Arg Thr Ser Ser 
            660                 665                 670         


Gly Ser Ser Ser Ser Ser Ser Thr Pro Ser Ser Gln Pro Ser Ser Gln 
        675                 680                 685             


Gly Gly Ser Gln Pro Gly Ser Gln Ala Gly Ser Ser Glu Arg Thr Arg 
    690                 695                 700                 


Val Arg Ala Asn Ser Lys Ser Glu Gly Ser Pro Val Leu Pro His Glu 
705                 710                 715                 720 


Pro Ala Lys Val Lys Pro Glu Glu Ser Arg Asp Ile Thr Arg Pro Ser 
                725                 730                 735     


Arg Pro Ala Asp Leu Thr Ala Leu Ala Lys Glu Leu Arg Glu Leu Arg 
            740                 745                 750         


Ile Glu Glu Thr Asn Arg Pro Met Lys Lys Val Thr Asp Tyr Ser Ser 
        755                 760                 765             


Ser Ser Glu Glu Ser Glu Ser Ser Glu Glu Glu Glu Glu Asp Gly Glu 
    770                 775                 780                 


Ser Glu Thr His Asp Gly Thr Val Ala Val Ser Asp Ile Pro Arg Leu 
785                 790                 795                 800 


Ile Pro Thr Gly Ala Pro Gly Ser Asn Glu Gln Tyr Asn Val Gly Met 
                805                 810                 815     


Val Gly Thr His Gly Leu Glu Thr Ser His Ala Asp Ser Phe Ser Gly 
            820                 825                 830         


Ser Ile Ser Arg Glu Gly Thr Leu Met Ile Arg Glu Thr Ser Gly Glu 
        835                 840                 845             


Lys Lys Arg Ser Gly His Ser Asp Ser Asn Gly Phe Ala Gly His Ile 
    850                 855                 860                 


Asn Leu Pro Asp Leu Val Gln Gln Ser His Ser Pro Ala Gly Thr Pro 
865                 870                 875                 880 


Thr Glu Gly Leu Gly Arg Val Ser Thr His Ser Gln Glu Met Asp Ser 
                885                 890                 895     


Gly Thr Glu Tyr Gly Met Gly Ser Ser Thr Lys Ala Ser Phe Thr Pro 
            900                 905                 910         


Phe Val Asp Pro Arg Val Tyr Gln Thr Ser Pro Thr Asp Glu Asp Glu 
        915                 920                 925             


Glu Asp Glu Glu Ser Ser Ala Ala Ala Leu Phe Thr Ser Glu Leu Leu 
    930                 935                 940                 


Arg Gln Glu Gln Ala Lys Leu Asn Glu Ala Arg Lys Ile Ser Val Val 
945                 950                 955                 960 


Asn Val Asn Pro Thr Asn Ile Arg Pro His Ser Asp Thr Pro Glu Ile 
                965                 970                 975     


Arg Lys Tyr Lys Lys Arg Phe Asn Ser Glu Ile Leu Cys Ala Ala Leu 
            980                 985                 990         


Trp Gly Val Asn Leu Leu Val Gly  Thr Glu Asn Gly Leu  Met Leu Leu 
        995                 1000                 1005             


Asp Arg  Ser Gly Gln Gly Lys  Val Tyr Asn Leu Ile  Asn Arg Arg 
    1010                 1015                 1020             


Arg Phe  Gln Gln Met Asp Val  Leu Glu Gly Leu Asn  Val Leu Val 
    1025                 1030                 1035             


Thr Ile  Ser Gly Lys Lys Asn  Lys Leu Arg Val Tyr  Tyr Leu Ser 
    1040                 1045                 1050             


Trp Leu  Arg Asn Arg Ile Leu  His Asn Asp Pro Glu  Val Glu Lys 
    1055                 1060                 1065             


Lys Gln  Gly Trp Ile Thr Val  Gly Asp Leu Glu Gly  Cys Ile His 
    1070                 1075                 1080             


Tyr Lys  Val Val Lys Tyr Glu  Arg Ile Lys Phe Leu  Val Ile Ala 
    1085                 1090                 1095             


Leu Lys  Asn Ala Val Glu Ile  Tyr Ala Trp Ala Pro  Lys Pro Tyr 
    1100                 1105                 1110             


His Lys  Phe Met Ala Phe Lys  Ser Phe Ala Asp Leu  Gln His Lys 
    1115                 1120                 1125             


Pro Leu  Leu Val Asp Leu Thr  Val Glu Glu Gly Gln  Arg Leu Lys 
    1130                 1135                 1140             


Val Ile  Phe Gly Ser His Thr  Gly Phe His Val Ile  Asp Val Asp 
    1145                 1150                 1155             


Ser Gly  Asn Ser Tyr Asp Ile  Tyr Ile Pro Ser His  Ile Gln Gly 
    1160                 1165                 1170             


Asn Ile  Thr Pro His Ala Ile  Val Ile Leu Pro Lys  Thr Asp Gly 
    1175                 1180                 1185             


Met Glu  Met Leu Val Cys Tyr  Glu Asp Glu Gly Val  Tyr Val Asn 
    1190                 1195                 1200             


Thr Tyr  Gly Arg Ile Thr Lys  Asp Val Val Leu Gln  Trp Gly Glu 
    1205                 1210                 1215             


Met Pro  Thr Ser Val Ala Tyr  Ile His Ser Asn Gln  Ile Met Gly 
    1220                 1225                 1230             


Trp Gly  Glu Lys Ala Ile Glu  Ile Arg Ser Val Glu  Thr Gly His 
    1235                 1240                 1245             


Leu Asp  Gly Val Phe Met His  Lys Arg Ala Gln Arg  Leu Lys Phe 
    1250                 1255                 1260             


Leu Cys  Glu Arg Asn Asp Lys  Val Phe Phe Ala Ser  Val Arg Ser 
    1265                 1270                 1275             


Gly Gly  Ser Ser Gln Val Phe  Phe Met Thr Leu Asn  Arg Asn Ser 
    1280                 1285                 1290             


Met Met  Asn Trp 
    1295         


<210>  37
<211>  5564
<212>  DNA
<213>  Homo sapiens

<400>  37
attataacag ccaatgcagc cgccatccac gcacaagcaa agaagcatgt cccatttaaa       60

tacacccacg cagccccagc gcccttagcc gatcggggcg ctcagcccac acgcaccgct      120

gctcggggct tggagatccg cgcaggctgg gctcccggac ccggcggacc gacgcgcgga      180

ggatcgggat ccggcgctgt ggggctgggg tgggcggggg aggctgggcc cggggcctct      240

ggcgcgacac ccgcatgagg acgcgagtga aatagaccaa ggtggaattt ccaagggaaa      300

agcttcgggg tggttttggt ccatttctcc agcgaagaag tagacatggc gagcgactcc      360

ccggctcgaa gcctggatga aatagatctc tcggctctga gggaccccgc agggatcttt      420

gaattggtgg aacttgttgg aaatggaaca tacgggcaag tttataaggg tcgtcatgtc      480

aaaacgggcc agcttgcagc catcaaggtt atggatgtca caggggatga agaggaagaa      540

atcaaacaag aaattaacat gttgaagaaa tattctcatc accggaatat tgctacatac      600

tatggtgctt ttatcaaaaa gaacccacca ggcatggatg accaactttg gttggtgatg      660

gagttttgtg gtgctggctc tgtcaccgac ctgatcaaga acacaaaagg taacacgttg      720

aaagaggagt ggattgcata catctgcagg gaaatcttac gggggctgag tcacctgcac      780

cagcataaag tgattcatcg agatattaaa gggcaaaatg tcttgctgac tgaaaatgca      840

gaagttaaac tagtggactt tggagtcagt gctcagcttg atcgaacagt gggcaggagg      900

aatactttca ttggaactcc ctactggatg gcaccagaag ttattgcctg tgatgaaaac      960

ccagatgcca catatgattt caagagtgac ttgtggtctt tgggtatcac cgccattgaa     1020

atggcagaag gtgctccccc tctctgtgac atgcacccca tgagagctct cttcctcatc     1080

ccccggaacc cagcgcctcg gctgaagtct aagaagtggt caaaaaaatt ccagtcattt     1140

attgagagct gcttggtaaa gaatcacagc cagcgaccag caacagaaca attgatgaag     1200

catccattta tacgagacca acctaatgag cgacaggtcc gcattcaact caaggaccat     1260

attgatagaa caaagaagaa gcgaggagaa aaagatgaga cagagtatga gtacagtgga     1320

agtgaggaag aagaggagga gaatgactca ggagagccca gctccatcct gaatctgcca     1380

ggggagtcga cgctgcggag ggactttctg aggctgcagc tggccaacaa ggagcgttct     1440

gaggccctac ggaggcagca gctggagcag cagcagcggg agaatgagga gcacaagcgg     1500

cagctgctgg ccgagcgtca gaagcgcatc gaggagcaga aagagcagag gcggcggctg     1560

gaggagcaac aaaggcgaga gaaggagctg cggaagcagc aggagaggga gcagcgccgg     1620

cactatgagg agcagatgcg ccgggaggag gagaggaggc gtgcggagca tgaacaggaa     1680

tataagcgca aacaattgga agaacagaga caagcagaaa gactgcagag gcagctaaag     1740

caagaaagag actacttagt ttcccttcag catcagcggc aggagcagag gcctgtggag     1800

aagaagccac tgtaccatta caaagaagga atgagtccta gtgagaagcc agcatgggcc     1860

aaggagatcc cacatctggt agctgtaaaa tcccagggac ctgccttgac cgcctcccag     1920

tcagtgcacg agcagcccac aaagggcctc tctgggtttc aggaggctct gaacgtgacc     1980

tcccaccgcg tggagatgcc acgccagaac tcagatccca cctcggaaaa tcctcctctc     2040

cccactcgca ttgaaaagtt tgaccgaagc tcttggttac gacaggaaga agacattcca     2100

ccaaaggtgc ctcaaagaac aacttctata tccccagcat tagccagaaa gaattctcct     2160

gggaatggta gtgctctggg acccagacta ggatctcaac ccatcagagc aagcaaccct     2220

gatctccgga gaactgagcc catcttggag agccccttgc agaggaccag cagtggcagt     2280

tcctccagct ccagcacccc tagctcccag cccagctccc aaggaggctc ccagcctgga     2340

tcacaagcag gatccagtga acgcaccaga gttcgagcca acagtaagtc agaaggatca     2400

cctgtgctcc cccatgagcc tgccaaggtg aaaccagaag aatccaggga cattacccgg     2460

cccagtcgac cagctagcta caaaaaagct atagatgagg atctgacggc attagccaaa     2520

gaactaagag aactccggat tgaagaaaca aaccgcccaa tgaagaaggt gactgattac     2580

tcctcctcca gtgaggagtc agaaagtagc gaggaagagg aggaagatgg agagagcgag     2640

acccatgatg ggacagtggc tgtcagcgac atacccagac tgataccaac aggagctcca     2700

ggcagcaacg agcagtacaa tgtgggaatg gtggggacgc atgggctgga gacctctcat     2760

gcggacagtt tcagcggcag tatttcaaga gaaggaacct tgatgattag agagacgtct     2820

ggagagaaga agcgatctgg ccacagtgac agcaatggct ttgctggcca catcaacctc     2880

cctgacctgg tgcagcagag ccattctcca gctggaaccc cgactgaggg actggggcgc     2940

gtctcaaccc attcccagga gatggactct gggactgaat atggcatggg gagcagcacc     3000

aaagcctcct tcaccccctt tgtggacccc agagtatacc agacgtctcc cactgatgaa     3060

gatgaagagg atgaggaatc atcagccgca gctctgttta ctagcgaact tcttaggcaa     3120

gaacaggcca aactcaatga agcaagaaag atttcggtgg taaatgtaaa cccaaccaac     3180

attcggcctc atagcgacac accagaaatc agaaaataca agaaacgatt caactcagaa     3240

atactttgtg cagctctgtg gggtgtaaac cttctggtgg ggactgaaaa tggcctgatg     3300

cttttggacc gaagtgggca aggcaaagtc tataatctga tcaaccggag gcgatttcag     3360

cagatggatg tgctagaggg actgaatgtc cttgtgacaa tttcaggaaa gaagaataag     3420

ctacgagttt actatctttc atggttaaga aacagaatac tacataatga cccagaagta     3480

gaaaagaaac aaggctggat cactgttggg gacttggaag gctgtataca ttataaagtt     3540

gttaaatatg aaaggatcaa atttttggtg attgccttaa agaatgctgt ggaaatatat     3600

gcttgggctc ctaaaccgta tcataaattc atggcattta agtcttttgc agatctccag     3660

cacaagcctc tgctagttga tctcacggta gaagaaggtc aaagattaaa ggttattttt     3720

ggttcacaca ctggtttcca tgtaattgat gttgattcag gaaactctta tgatatctac     3780

ataccatctc atattcaggg caatatcact cctcatgcta ttgtcatctt gcctaaaaca     3840

gatggaatgg aaatgcttgt ttgctatgag gatgaggggg tgtatgtaaa cacctatggc     3900

cggataacta aggatgtggt gctccaatgg ggagaaatgc ccacgtctgt ggcctacatt     3960

cattccaatc agataatggg ctggggcgag aaagctattg agatccggtc agtggaaaca     4020

ggacatttgg atggagtatt tatgcataag cgagctcaaa ggttaaagtt tctatgtgaa     4080

agaaatgata aggtattttt tgcatccgtg cgatctggag gaagtagcca agtgtttttc     4140

atgaccctca acagaaattc catgatgaac tggtaacaga agagcacttg gcacttatct     4200

tcatggcgtt atttctaatt taaaagaaca taactcatgt ggacttatgc cagtctagag     4260

gcagaatcag aaggcttggt tgaacatatc gctttccctt tttcctctcc ctccgcccct     4320

cccagtacag tccatctttc aatgttgcag cctggttgag aaggagagaa aaaggtggca     4380

ggaatttcca ggagatcccc aagaatgctg ccttgtctgt ggacaaagat ggaccatgtg     4440

cccttcggaa ttagggatag aaacaaatat tgtgtgctct taacgattaa gctgtgttat     4500

ggtgggtttt caggttttta ccttttttct ttaccccttt actctgcaag aatggggaaa     4560

gaatgcatac tgcgaaaatg agtcttttaa attctgtctg cctactagtt ttaagtatat     4620

ggtatgttgt aaaatttcca atgatgagag acagcacaat aaatgtacct tatctcctta     4680

ggctgaaggc cataactaca tagtggagta atttaagaac tctcttgcct tcaccaaccc     4740

aaaaggttgc tttttgatag caactggcta atgaattttt aaaaagagaa gaaaaatact     4800

agttttcccc tcttttggga aatagatttt aaatggctaa actactagcc ttaaaactac     4860

tagtctaata aaatcaacta ccacttttgt gaatctgaca ggccacattt ttatatggcc     4920

ctttacagaa tggagtgtgt tgaacaggat actaacgcca ttgagttgag ctggcctagc     4980

gatggaggga cactctaaca caactttccc tcagctatta tgcaacagat cagggaaaaa     5040

gatgggatga cagatggggt cagacagaaa gagcttctgg gaaacaagct tacatagtct     5100

tttttaaaat gcacaaagcc tcccagctaa gaggtcactt ggtttgggct tcattaggac     5160

tgagactttg ttgagttctt tctgggactt ggagagtgga tgatattcag gctctgaaca     5220

ttcccagcgc tctcccgagg gtgccacttt ctcaagatga aaactgtgac tgaaaaaatt     5280

aataataaat gtttctgagc tgcctgtgtt ctccctgtgt gggtgagaga agggactaga     5340

ctcctaagcc tgcctcagat acaagaggca tcattggctc caattttaga gaacttgaaa     5400

gcaaggcttt ggacaaaatt ttgagaccct aatcacttta ccttcctcca aattacccaa     5460

catacggtaa acaacatttg tgcagaagta tgtatgtatt tagttcaggt tgacttgtgt     5520

ccttataaac tcttactcaa atgatttgaa ctttaaaaaa aaaa                      5564


<210>  38
<211>  1276
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Ser Asp Ser Pro Ala Arg Ser Leu Asp Glu Ile Asp Leu Ser 
1               5                   10                  15      


Ala Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Leu Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Gly Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Gln Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Asn Pro Pro Gly 
                85                  90                  95      


Met Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Val Thr Asp Leu Ile Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Glu 
        115                 120                 125             


Trp Ile Ala Tyr Ile Cys Arg Glu Ile Leu Arg Gly Leu Ser His Leu 
    130                 135                 140                 


His Gln His Lys Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala 
                165                 170                 175     


Gln Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro 
            180                 185                 190         


Tyr Trp Met Ala Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala 
        195                 200                 205             


Thr Tyr Asp Phe Lys Ser Asp Leu Trp Ser Leu Gly Ile Thr Ala Ile 
    210                 215                 220                 


Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 
225                 230                 235                 240 


Ala Leu Phe Leu Ile Pro Arg Asn Pro Ala Pro Arg Leu Lys Ser Lys 
                245                 250                 255     


Lys Trp Ser Lys Lys Phe Gln Ser Phe Ile Glu Ser Cys Leu Val Lys 
            260                 265                 270         


Asn His Ser Gln Arg Pro Ala Thr Glu Gln Leu Met Lys His Pro Phe 
        275                 280                 285             


Ile Arg Asp Gln Pro Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp 
    290                 295                 300                 


His Ile Asp Arg Thr Lys Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu 
305                 310                 315                 320 


Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Glu Glu Glu Asn Asp Ser Gly 
                325                 330                 335     


Glu Pro Ser Ser Ile Leu Asn Leu Pro Gly Glu Ser Thr Leu Arg Arg 
            340                 345                 350         


Asp Phe Leu Arg Leu Gln Leu Ala Asn Lys Glu Arg Ser Glu Ala Leu 
        355                 360                 365             


Arg Arg Gln Gln Leu Glu Gln Gln Gln Arg Glu Asn Glu Glu His Lys 
    370                 375                 380                 


Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu Glu Gln Lys Glu 
385                 390                 395                 400 


Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu Lys Glu Leu Arg 
                405                 410                 415     


Lys Gln Gln Glu Arg Glu Gln Arg Arg His Tyr Glu Glu Gln Met Arg 
            420                 425                 430         


Arg Glu Glu Glu Arg Arg Arg Ala Glu His Glu Gln Glu Tyr Lys Arg 
        435                 440                 445             


Lys Gln Leu Glu Glu Gln Arg Gln Ala Glu Arg Leu Gln Arg Gln Leu 
    450                 455                 460                 


Lys Gln Glu Arg Asp Tyr Leu Val Ser Leu Gln His Gln Arg Gln Glu 
465                 470                 475                 480 


Gln Arg Pro Val Glu Lys Lys Pro Leu Tyr His Tyr Lys Glu Gly Met 
                485                 490                 495     


Ser Pro Ser Glu Lys Pro Ala Trp Ala Lys Glu Ile Pro His Leu Val 
            500                 505                 510         


Ala Val Lys Ser Gln Gly Pro Ala Leu Thr Ala Ser Gln Ser Val His 
        515                 520                 525             


Glu Gln Pro Thr Lys Gly Leu Ser Gly Phe Gln Glu Ala Leu Asn Val 
    530                 535                 540                 


Thr Ser His Arg Val Glu Met Pro Arg Gln Asn Ser Asp Pro Thr Ser 
545                 550                 555                 560 


Glu Asn Pro Pro Leu Pro Thr Arg Ile Glu Lys Phe Asp Arg Ser Ser 
                565                 570                 575     


Trp Leu Arg Gln Glu Glu Asp Ile Pro Pro Lys Val Pro Gln Arg Thr 
            580                 585                 590         


Thr Ser Ile Ser Pro Ala Leu Ala Arg Lys Asn Ser Pro Gly Asn Gly 
        595                 600                 605             


Ser Ala Leu Gly Pro Arg Leu Gly Ser Gln Pro Ile Arg Ala Ser Asn 
    610                 615                 620                 


Pro Asp Leu Arg Arg Thr Glu Pro Ile Leu Glu Ser Pro Leu Gln Arg 
625                 630                 635                 640 


Thr Ser Ser Gly Ser Ser Ser Ser Ser Ser Thr Pro Ser Ser Gln Pro 
                645                 650                 655     


Ser Ser Gln Gly Gly Ser Gln Pro Gly Ser Gln Ala Gly Ser Ser Glu 
            660                 665                 670         


Arg Thr Arg Val Arg Ala Asn Ser Lys Ser Glu Gly Ser Pro Val Leu 
        675                 680                 685             


Pro His Glu Pro Ala Lys Val Lys Pro Glu Glu Ser Arg Asp Ile Thr 
    690                 695                 700                 


Arg Pro Ser Arg Pro Ala Ser Tyr Lys Lys Ala Ile Asp Glu Asp Leu 
705                 710                 715                 720 


Thr Ala Leu Ala Lys Glu Leu Arg Glu Leu Arg Ile Glu Glu Thr Asn 
                725                 730                 735     


Arg Pro Met Lys Lys Val Thr Asp Tyr Ser Ser Ser Ser Glu Glu Ser 
            740                 745                 750         


Glu Ser Ser Glu Glu Glu Glu Glu Asp Gly Glu Ser Glu Thr His Asp 
        755                 760                 765             


Gly Thr Val Ala Val Ser Asp Ile Pro Arg Leu Ile Pro Thr Gly Ala 
    770                 775                 780                 


Pro Gly Ser Asn Glu Gln Tyr Asn Val Gly Met Val Gly Thr His Gly 
785                 790                 795                 800 


Leu Glu Thr Ser His Ala Asp Ser Phe Ser Gly Ser Ile Ser Arg Glu 
                805                 810                 815     


Gly Thr Leu Met Ile Arg Glu Thr Ser Gly Glu Lys Lys Arg Ser Gly 
            820                 825                 830         


His Ser Asp Ser Asn Gly Phe Ala Gly His Ile Asn Leu Pro Asp Leu 
        835                 840                 845             


Val Gln Gln Ser His Ser Pro Ala Gly Thr Pro Thr Glu Gly Leu Gly 
    850                 855                 860                 


Arg Val Ser Thr His Ser Gln Glu Met Asp Ser Gly Thr Glu Tyr Gly 
865                 870                 875                 880 


Met Gly Ser Ser Thr Lys Ala Ser Phe Thr Pro Phe Val Asp Pro Arg 
                885                 890                 895     


Val Tyr Gln Thr Ser Pro Thr Asp Glu Asp Glu Glu Asp Glu Glu Ser 
            900                 905                 910         


Ser Ala Ala Ala Leu Phe Thr Ser Glu Leu Leu Arg Gln Glu Gln Ala 
        915                 920                 925             


Lys Leu Asn Glu Ala Arg Lys Ile Ser Val Val Asn Val Asn Pro Thr 
    930                 935                 940                 


Asn Ile Arg Pro His Ser Asp Thr Pro Glu Ile Arg Lys Tyr Lys Lys 
945                 950                 955                 960 


Arg Phe Asn Ser Glu Ile Leu Cys Ala Ala Leu Trp Gly Val Asn Leu 
                965                 970                 975     


Leu Val Gly Thr Glu Asn Gly Leu Met Leu Leu Asp Arg Ser Gly Gln 
            980                 985                 990         


Gly Lys Val Tyr Asn Leu Ile Asn  Arg Arg Arg Phe Gln  Gln Met Asp 
        995                 1000                 1005             


Val Leu  Glu Gly Leu Asn Val  Leu Val Thr Ile Ser  Gly Lys Lys 
    1010                 1015                 1020             


Asn Lys  Leu Arg Val Tyr Tyr  Leu Ser Trp Leu Arg  Asn Arg Ile 
    1025                 1030                 1035             


Leu His  Asn Asp Pro Glu Val  Glu Lys Lys Gln Gly  Trp Ile Thr 
    1040                 1045                 1050             


Val Gly  Asp Leu Glu Gly Cys  Ile His Tyr Lys Val  Val Lys Tyr 
    1055                 1060                 1065             


Glu Arg  Ile Lys Phe Leu Val  Ile Ala Leu Lys Asn  Ala Val Glu 
    1070                 1075                 1080             


Ile Tyr  Ala Trp Ala Pro Lys  Pro Tyr His Lys Phe  Met Ala Phe 
    1085                 1090                 1095             


Lys Ser  Phe Ala Asp Leu Gln  His Lys Pro Leu Leu  Val Asp Leu 
    1100                 1105                 1110             


Thr Val  Glu Glu Gly Gln Arg  Leu Lys Val Ile Phe  Gly Ser His 
    1115                 1120                 1125             


Thr Gly  Phe His Val Ile Asp  Val Asp Ser Gly Asn  Ser Tyr Asp 
    1130                 1135                 1140             


Ile Tyr  Ile Pro Ser His Ile  Gln Gly Asn Ile Thr  Pro His Ala 
    1145                 1150                 1155             


Ile Val  Ile Leu Pro Lys Thr  Asp Gly Met Glu Met  Leu Val Cys 
    1160                 1165                 1170             


Tyr Glu  Asp Glu Gly Val Tyr  Val Asn Thr Tyr Gly  Arg Ile Thr 
    1175                 1180                 1185             


Lys Asp  Val Val Leu Gln Trp  Gly Glu Met Pro Thr  Ser Val Ala 
    1190                 1195                 1200             


Tyr Ile  His Ser Asn Gln Ile  Met Gly Trp Gly Glu  Lys Ala Ile 
    1205                 1210                 1215             


Glu Ile  Arg Ser Val Glu Thr  Gly His Leu Asp Gly  Val Phe Met 
    1220                 1225                 1230             


His Lys  Arg Ala Gln Arg Leu  Lys Phe Leu Cys Glu  Arg Asn Asp 
    1235                 1240                 1245             


Lys Val  Phe Phe Ala Ser Val  Arg Ser Gly Gly Ser  Ser Gln Val 
    1250                 1255                 1260             


Phe Phe  Met Thr Leu Asn Arg  Asn Ser Met Met Asn  Trp 
    1265                 1270                 1275     


<210>  39
<211>  5540
<212>  DNA
<213>  Homo sapiens

<400>  39
attataacag ccaatgcagc cgccatccac gcacaagcaa agaagcatgt cccatttaaa       60

tacacccacg cagccccagc gcccttagcc gatcggggcg ctcagcccac acgcaccgct      120

gctcggggct tggagatccg cgcaggctgg gctcccggac ccggcggacc gacgcgcgga      180

ggatcgggat ccggcgctgt ggggctgggg tgggcggggg aggctgggcc cggggcctct      240

ggcgcgacac ccgcatgagg acgcgagtga aatagaccaa ggtggaattt ccaagggaaa      300

agcttcgggg tggttttggt ccatttctcc agcgaagaag tagacatggc gagcgactcc      360

ccggctcgaa gcctggatga aatagatctc tcggctctga gggaccccgc agggatcttt      420

gaattggtgg aacttgttgg aaatggaaca tacgggcaag tttataaggg tcgtcatgtc      480

aaaacgggcc agcttgcagc catcaaggtt atggatgtca caggggatga agaggaagaa      540

atcaaacaag aaattaacat gttgaagaaa tattctcatc accggaatat tgctacatac      600

tatggtgctt ttatcaaaaa gaacccacca ggcatggatg accaactttg gttggtgatg      660

gagttttgtg gtgctggctc tgtcaccgac ctgatcaaga acacaaaagg taacacgttg      720

aaagaggagt ggattgcata catctgcagg gaaatcttac gggggctgag tcacctgcac      780

cagcataaag tgattcatcg agatattaaa gggcaaaatg tcttgctgac tgaaaatgca      840

gaagttaaac tagtggactt tggagtcagt gctcagcttg atcgaacagt gggcaggagg      900

aatactttca ttggaactcc ctactggatg gcaccagaag ttattgcctg tgatgaaaac      960

ccagatgcca catatgattt caagagtgac ttgtggtctt tgggtatcac cgccattgaa     1020

atggcagaag gtgctccccc tctctgtgac atgcacccca tgagagctct cttcctcatc     1080

ccccggaacc cagcgcctcg gctgaagtct aagaagtggt caaaaaaatt ccagtcattt     1140

attgagagct gcttggtaaa gaatcacagc cagcgaccag caacagaaca attgatgaag     1200

catccattta tacgagacca acctaatgag cgacaggtcc gcattcaact caaggaccat     1260

attgatagaa caaagaagaa gcgaggagaa aaagatgaga cagagtatga gtacagtgga     1320

agtgaggaag aagaggagga gaatgactca ggagagccca gctccatcct gaatctgcca     1380

ggggagtcga cgctgcggag ggactttctg aggctgcagc tggccaacaa ggagcgttct     1440

gaggccctac ggaggcagca gctggagcag cagcagcggg agaatgagga gcacaagcgg     1500

cagctgctgg ccgagcgtca gaagcgcatc gaggagcaga aagagcagag gcggcggctg     1560

gaggagcaac aaaggcgaga gaaggagctg cggaagcagc aggagaggga gcagcgccgg     1620

cactatgagg agcagatgcg ccgggaggag gagaggaggc gtgcggagca tgaacaggaa     1680

tataagcgca aacaattgga agaacagaga caagcagaaa gactgcagag gcagctaaag     1740

caagaaagag actacttagt ttcccttcag catcagcggc aggagcagag gcctgtggag     1800

aagaagccac tgtaccatta caaagaagga atgagtccta gtgagaagcc agcatgggcc     1860

aaggagatcc cacatctggt agctgtaaaa tcccagggac ctgccttgac cgcctcccag     1920

tcagtgcacg agcagcccac aaagggcctc tctgggtttc aggaggctct gaacgtgacc     1980

tcccaccgcg tggagatgcc acgccagaac tcagatccca cctcggaaaa tcctcctctc     2040

cccactcgca ttgaaaagtt tgaccgaagc tcttggttac gacaggaaga agacattcca     2100

ccaaaggtgc ctcaaagaac aacttctata tccccagcat tagccagaaa gaattctcct     2160

gggaatggta gtgctctggg acccagacta ggatctcaac ccatcagagc aagcaaccct     2220

gatctccgga gaactgagcc catcttggag agccccttgc agaggaccag cagtggcagt     2280

tcctccagct ccagcacccc tagctcccag cccagctccc aaggaggctc ccagcctgga     2340

tcacaagcag gatccagtga acgcaccaga gttcgagcca acagtaagtc agaaggatca     2400

cctgtgctcc cccatgagcc tgccaaggtg aaaccagaag aatccaggga cattacccgg     2460

cccagtcgac cagctgatct gacggcatta gccaaagaac taagagaact ccggattgaa     2520

gaaacaaacc gcccaatgaa gaaggtgact gattactcct cctccagtga ggagtcagaa     2580

agtagcgagg aagaggagga agatggagag agcgagaccc atgatgggac agtggctgtc     2640

agcgacatac ccagactgat accaacagga gctccaggca gcaacgagca gtacaatgtg     2700

ggaatggtgg ggacgcatgg gctggagacc tctcatgcgg acagtttcag cggcagtatt     2760

tcaagagaag gaaccttgat gattagagag acgtctggag agaagaagcg atctggccac     2820

agtgacagca atggctttgc tggccacatc aacctccctg acctggtgca gcagagccat     2880

tctccagctg gaaccccgac tgagggactg gggcgcgtct caacccattc ccaggagatg     2940

gactctggga ctgaatatgg catggggagc agcaccaaag cctccttcac cccctttgtg     3000

gaccccagag tataccagac gtctcccact gatgaagatg aagaggatga ggaatcatca     3060

gccgcagctc tgtttactag cgaacttctt aggcaagaac aggccaaact caatgaagca     3120

agaaagattt cggtggtaaa tgtaaaccca accaacattc ggcctcatag cgacacacca     3180

gaaatcagaa aatacaagaa acgattcaac tcagaaatac tttgtgcagc tctgtggggt     3240

gtaaaccttc tggtggggac tgaaaatggc ctgatgcttt tggaccgaag tgggcaaggc     3300

aaagtctata atctgatcaa ccggaggcga tttcagcaga tggatgtgct agagggactg     3360

aatgtccttg tgacaatttc aggaaagaag aataagctac gagtttacta tctttcatgg     3420

ttaagaaaca gaatactaca taatgaccca gaagtagaaa agaaacaagg ctggatcact     3480

gttggggact tggaaggctg tatacattat aaagttgtta aatatgaaag gatcaaattt     3540

ttggtgattg ccttaaagaa tgctgtggaa atatatgctt gggctcctaa accgtatcat     3600

aaattcatgg catttaagtc ttttgcagat ctccagcaca agcctctgct agttgatctc     3660

acggtagaag aaggtcaaag attaaaggtt atttttggtt cacacactgg tttccatgta     3720

attgatgttg attcaggaaa ctcttatgat atctacatac catctcatat tcagggcaat     3780

atcactcctc atgctattgt catcttgcct aaaacagatg gaatggaaat gcttgtttgc     3840

tatgaggatg agggggtgta tgtaaacacc tatggccgga taactaagga tgtggtgctc     3900

caatggggag aaatgcccac gtctgtggcc tacattcatt ccaatcagat aatgggctgg     3960

ggcgagaaag ctattgagat ccggtcagtg gaaacaggac atttggatgg agtatttatg     4020

cataagcgag ctcaaaggtt aaagtttcta tgtgaaagaa atgataaggt attttttgca     4080

tccgtgcgat ctggaggaag tagccaagtg tttttcatga ccctcaacag aaattccatg     4140

atgaactggt aacagaagag cacttggcac ttatcttcat ggcgttattt ctaatttaaa     4200

agaacataac tcatgtggac ttatgccagt ctagaggcag aatcagaagg cttggttgaa     4260

catatcgctt tccctttttc ctctccctcc gcccctccca gtacagtcca tctttcaatg     4320

ttgcagcctg gttgagaagg agagaaaaag gtggcaggaa tttccaggag atccccaaga     4380

atgctgcctt gtctgtggac aaagatggac catgtgccct tcggaattag ggatagaaac     4440

aaatattgtg tgctcttaac gattaagctg tgttatggtg ggttttcagg tttttacctt     4500

ttttctttac ccctttactc tgcaagaatg gggaaagaat gcatactgcg aaaatgagtc     4560

ttttaaattc tgtctgccta ctagttttaa gtatatggta tgttgtaaaa tttccaatga     4620

tgagagacag cacaataaat gtaccttatc tccttaggct gaaggccata actacatagt     4680

ggagtaattt aagaactctc ttgccttcac caacccaaaa ggttgctttt tgatagcaac     4740

tggctaatga atttttaaaa agagaagaaa aatactagtt ttcccctctt ttgggaaata     4800

gattttaaat ggctaaacta ctagccttaa aactactagt ctaataaaat caactaccac     4860

ttttgtgaat ctgacaggcc acatttttat atggcccttt acagaatgga gtgtgttgaa     4920

caggatacta acgccattga gttgagctgg cctagcgatg gagggacact ctaacacaac     4980

tttccctcag ctattatgca acagatcagg gaaaaagatg ggatgacaga tggggtcaga     5040

cagaaagagc ttctgggaaa caagcttaca tagtcttttt taaaatgcac aaagcctccc     5100

agctaagagg tcacttggtt tgggcttcat taggactgag actttgttga gttctttctg     5160

ggacttggag agtggatgat attcaggctc tgaacattcc cagcgctctc ccgagggtgc     5220

cactttctca agatgaaaac tgtgactgaa aaaattaata ataaatgttt ctgagctgcc     5280

tgtgttctcc ctgtgtgggt gagagaaggg actagactcc taagcctgcc tcagatacaa     5340

gaggcatcat tggctccaat tttagagaac ttgaaagcaa ggctttggac aaaattttga     5400

gaccctaatc actttacctt cctccaaatt acccaacata cggtaaacaa catttgtgca     5460

gaagtatgta tgtatttagt tcaggttgac ttgtgtcctt ataaactctt actcaaatga     5520

tttgaacttt aaaaaaaaaa                                                 5540


<210>  40
<211>  1268
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Ser Asp Ser Pro Ala Arg Ser Leu Asp Glu Ile Asp Leu Ser 
1               5                   10                  15      


Ala Leu Arg Asp Pro Ala Gly Ile Phe Glu Leu Val Glu Leu Val Gly 
            20                  25                  30          


Asn Gly Thr Tyr Gly Gln Val Tyr Lys Gly Arg His Val Lys Thr Gly 
        35                  40                  45              


Gln Leu Ala Ala Ile Lys Val Met Asp Val Thr Gly Asp Glu Glu Glu 
    50                  55                  60                  


Glu Ile Lys Gln Glu Ile Asn Met Leu Lys Lys Tyr Ser His His Arg 
65                  70                  75                  80  


Asn Ile Ala Thr Tyr Tyr Gly Ala Phe Ile Lys Lys Asn Pro Pro Gly 
                85                  90                  95      


Met Asp Asp Gln Leu Trp Leu Val Met Glu Phe Cys Gly Ala Gly Ser 
            100                 105                 110         


Val Thr Asp Leu Ile Lys Asn Thr Lys Gly Asn Thr Leu Lys Glu Glu 
        115                 120                 125             


Trp Ile Ala Tyr Ile Cys Arg Glu Ile Leu Arg Gly Leu Ser His Leu 
    130                 135                 140                 


His Gln His Lys Val Ile His Arg Asp Ile Lys Gly Gln Asn Val Leu 
145                 150                 155                 160 


Leu Thr Glu Asn Ala Glu Val Lys Leu Val Asp Phe Gly Val Ser Ala 
                165                 170                 175     


Gln Leu Asp Arg Thr Val Gly Arg Arg Asn Thr Phe Ile Gly Thr Pro 
            180                 185                 190         


Tyr Trp Met Ala Pro Glu Val Ile Ala Cys Asp Glu Asn Pro Asp Ala 
        195                 200                 205             


Thr Tyr Asp Phe Lys Ser Asp Leu Trp Ser Leu Gly Ile Thr Ala Ile 
    210                 215                 220                 


Glu Met Ala Glu Gly Ala Pro Pro Leu Cys Asp Met His Pro Met Arg 
225                 230                 235                 240 


Ala Leu Phe Leu Ile Pro Arg Asn Pro Ala Pro Arg Leu Lys Ser Lys 
                245                 250                 255     


Lys Trp Ser Lys Lys Phe Gln Ser Phe Ile Glu Ser Cys Leu Val Lys 
            260                 265                 270         


Asn His Ser Gln Arg Pro Ala Thr Glu Gln Leu Met Lys His Pro Phe 
        275                 280                 285             


Ile Arg Asp Gln Pro Asn Glu Arg Gln Val Arg Ile Gln Leu Lys Asp 
    290                 295                 300                 


His Ile Asp Arg Thr Lys Lys Lys Arg Gly Glu Lys Asp Glu Thr Glu 
305                 310                 315                 320 


Tyr Glu Tyr Ser Gly Ser Glu Glu Glu Glu Glu Glu Asn Asp Ser Gly 
                325                 330                 335     


Glu Pro Ser Ser Ile Leu Asn Leu Pro Gly Glu Ser Thr Leu Arg Arg 
            340                 345                 350         


Asp Phe Leu Arg Leu Gln Leu Ala Asn Lys Glu Arg Ser Glu Ala Leu 
        355                 360                 365             


Arg Arg Gln Gln Leu Glu Gln Gln Gln Arg Glu Asn Glu Glu His Lys 
    370                 375                 380                 


Arg Gln Leu Leu Ala Glu Arg Gln Lys Arg Ile Glu Glu Gln Lys Glu 
385                 390                 395                 400 


Gln Arg Arg Arg Leu Glu Glu Gln Gln Arg Arg Glu Lys Glu Leu Arg 
                405                 410                 415     


Lys Gln Gln Glu Arg Glu Gln Arg Arg His Tyr Glu Glu Gln Met Arg 
            420                 425                 430         


Arg Glu Glu Glu Arg Arg Arg Ala Glu His Glu Gln Glu Tyr Lys Arg 
        435                 440                 445             


Lys Gln Leu Glu Glu Gln Arg Gln Ala Glu Arg Leu Gln Arg Gln Leu 
    450                 455                 460                 


Lys Gln Glu Arg Asp Tyr Leu Val Ser Leu Gln His Gln Arg Gln Glu 
465                 470                 475                 480 


Gln Arg Pro Val Glu Lys Lys Pro Leu Tyr His Tyr Lys Glu Gly Met 
                485                 490                 495     


Ser Pro Ser Glu Lys Pro Ala Trp Ala Lys Glu Ile Pro His Leu Val 
            500                 505                 510         


Ala Val Lys Ser Gln Gly Pro Ala Leu Thr Ala Ser Gln Ser Val His 
        515                 520                 525             


Glu Gln Pro Thr Lys Gly Leu Ser Gly Phe Gln Glu Ala Leu Asn Val 
    530                 535                 540                 


Thr Ser His Arg Val Glu Met Pro Arg Gln Asn Ser Asp Pro Thr Ser 
545                 550                 555                 560 


Glu Asn Pro Pro Leu Pro Thr Arg Ile Glu Lys Phe Asp Arg Ser Ser 
                565                 570                 575     


Trp Leu Arg Gln Glu Glu Asp Ile Pro Pro Lys Val Pro Gln Arg Thr 
            580                 585                 590         


Thr Ser Ile Ser Pro Ala Leu Ala Arg Lys Asn Ser Pro Gly Asn Gly 
        595                 600                 605             


Ser Ala Leu Gly Pro Arg Leu Gly Ser Gln Pro Ile Arg Ala Ser Asn 
    610                 615                 620                 


Pro Asp Leu Arg Arg Thr Glu Pro Ile Leu Glu Ser Pro Leu Gln Arg 
625                 630                 635                 640 


Thr Ser Ser Gly Ser Ser Ser Ser Ser Ser Thr Pro Ser Ser Gln Pro 
                645                 650                 655     


Ser Ser Gln Gly Gly Ser Gln Pro Gly Ser Gln Ala Gly Ser Ser Glu 
            660                 665                 670         


Arg Thr Arg Val Arg Ala Asn Ser Lys Ser Glu Gly Ser Pro Val Leu 
        675                 680                 685             


Pro His Glu Pro Ala Lys Val Lys Pro Glu Glu Ser Arg Asp Ile Thr 
    690                 695                 700                 


Arg Pro Ser Arg Pro Ala Asp Leu Thr Ala Leu Ala Lys Glu Leu Arg 
705                 710                 715                 720 


Glu Leu Arg Ile Glu Glu Thr Asn Arg Pro Met Lys Lys Val Thr Asp 
                725                 730                 735     


Tyr Ser Ser Ser Ser Glu Glu Ser Glu Ser Ser Glu Glu Glu Glu Glu 
            740                 745                 750         


Asp Gly Glu Ser Glu Thr His Asp Gly Thr Val Ala Val Ser Asp Ile 
        755                 760                 765             


Pro Arg Leu Ile Pro Thr Gly Ala Pro Gly Ser Asn Glu Gln Tyr Asn 
    770                 775                 780                 


Val Gly Met Val Gly Thr His Gly Leu Glu Thr Ser His Ala Asp Ser 
785                 790                 795                 800 


Phe Ser Gly Ser Ile Ser Arg Glu Gly Thr Leu Met Ile Arg Glu Thr 
                805                 810                 815     


Ser Gly Glu Lys Lys Arg Ser Gly His Ser Asp Ser Asn Gly Phe Ala 
            820                 825                 830         


Gly His Ile Asn Leu Pro Asp Leu Val Gln Gln Ser His Ser Pro Ala 
        835                 840                 845             


Gly Thr Pro Thr Glu Gly Leu Gly Arg Val Ser Thr His Ser Gln Glu 
    850                 855                 860                 


Met Asp Ser Gly Thr Glu Tyr Gly Met Gly Ser Ser Thr Lys Ala Ser 
865                 870                 875                 880 


Phe Thr Pro Phe Val Asp Pro Arg Val Tyr Gln Thr Ser Pro Thr Asp 
                885                 890                 895     


Glu Asp Glu Glu Asp Glu Glu Ser Ser Ala Ala Ala Leu Phe Thr Ser 
            900                 905                 910         


Glu Leu Leu Arg Gln Glu Gln Ala Lys Leu Asn Glu Ala Arg Lys Ile 
        915                 920                 925             


Ser Val Val Asn Val Asn Pro Thr Asn Ile Arg Pro His Ser Asp Thr 
    930                 935                 940                 


Pro Glu Ile Arg Lys Tyr Lys Lys Arg Phe Asn Ser Glu Ile Leu Cys 
945                 950                 955                 960 


Ala Ala Leu Trp Gly Val Asn Leu Leu Val Gly Thr Glu Asn Gly Leu 
                965                 970                 975     


Met Leu Leu Asp Arg Ser Gly Gln Gly Lys Val Tyr Asn Leu Ile Asn 
            980                 985                 990         


Arg Arg Arg Phe Gln Gln Met Asp  Val Leu Glu Gly Leu  Asn Val Leu 
        995                 1000                 1005             


Val Thr  Ile Ser Gly Lys Lys  Asn Lys Leu Arg Val  Tyr Tyr Leu 
    1010                 1015                 1020             


Ser Trp  Leu Arg Asn Arg Ile  Leu His Asn Asp Pro  Glu Val Glu 
    1025                 1030                 1035             


Lys Lys  Gln Gly Trp Ile Thr  Val Gly Asp Leu Glu  Gly Cys Ile 
    1040                 1045                 1050             


His Tyr  Lys Val Val Lys Tyr  Glu Arg Ile Lys Phe  Leu Val Ile 
    1055                 1060                 1065             


Ala Leu  Lys Asn Ala Val Glu  Ile Tyr Ala Trp Ala  Pro Lys Pro 
    1070                 1075                 1080             


Tyr His  Lys Phe Met Ala Phe  Lys Ser Phe Ala Asp  Leu Gln His 
    1085                 1090                 1095             


Lys Pro  Leu Leu Val Asp Leu  Thr Val Glu Glu Gly  Gln Arg Leu 
    1100                 1105                 1110             


Lys Val  Ile Phe Gly Ser His  Thr Gly Phe His Val  Ile Asp Val 
    1115                 1120                 1125             


Asp Ser  Gly Asn Ser Tyr Asp  Ile Tyr Ile Pro Ser  His Ile Gln 
    1130                 1135                 1140             


Gly Asn  Ile Thr Pro His Ala  Ile Val Ile Leu Pro  Lys Thr Asp 
    1145                 1150                 1155             


Gly Met  Glu Met Leu Val Cys  Tyr Glu Asp Glu Gly  Val Tyr Val 
    1160                 1165                 1170             


Asn Thr  Tyr Gly Arg Ile Thr  Lys Asp Val Val Leu  Gln Trp Gly 
    1175                 1180                 1185             


Glu Met  Pro Thr Ser Val Ala  Tyr Ile His Ser Asn  Gln Ile Met 
    1190                 1195                 1200             


Gly Trp  Gly Glu Lys Ala Ile  Glu Ile Arg Ser Val  Glu Thr Gly 
    1205                 1210                 1215             


His Leu  Asp Gly Val Phe Met  His Lys Arg Ala Gln  Arg Leu Lys 
    1220                 1225                 1230             


Phe Leu  Cys Glu Arg Asn Asp  Lys Val Phe Phe Ala  Ser Val Arg 
    1235                 1240                 1245             


Ser Gly  Gly Ser Ser Gln Val  Phe Phe Met Thr Leu  Asn Arg Asn 
    1250                 1255                 1260             


Ser Met  Met Asn Trp 
    1265             


<210>  41
<211>  1453
<212>  DNA
<213>  Homo sapiens

<400>  41
cgcaaaggac ctgacgacgt gctgcgtcgt tacttttgaa acgcttggcg gggaagtgct       60

gttggagccg ctgtggttgc tgtccgcgga gtggaagcgc gtgcttttgt ttgtgtccct      120

ggccatggcg ctgcagctct cccgggagca gggaatcacc ctgcgcggga gcgccgaaat      180

cgtggccgag ttcttctcat tcggcatcaa cagcatttta tatcagcgtg gcatatatcc      240

atctgaaacc tttactcgag tgcagaaata cggactcacc ttgcttgtaa ctactgatct      300

tgagctcata aaatacctaa ataatgtggt ggaacaactg aaagattggt tatacaagtg      360

ttcagttcag aaactggttg tagttatctc aaatattgaa agtggtgagg tcctggaaag      420

atggcagttt gatattgagt gtgacaagac tgcaaaagat gacagtgcac ccagagaaaa      480

gtctcagaaa gctatccagg atgaaatccg ttcagtgatc agacagatca cagctacggt      540

gacatttctg ccactgttgg aagtttcttg ttcatttgat ctgctgattt atacagacaa      600

agatttggtt gtacctgaaa aatgggaaga gtcgggacca cagtttatta ccaattctga      660

ggaagtccgc cttcgttcat ttactactac aatccacaaa gtaaatagca tggtggccta      720

caaaattcct gtcaatgact gaggatgaca tgaggaaaat aatgtaattg taattttgaa      780

atgtggtttt cctgaaatca agtcatctat agttgatatg ttttatttca ttggttaatt      840

tttacatgga gaaaaccaaa atgatactta ctgaactgtg tgtaattgtt ccttttattt      900

ttttggtacc tatttgactt accatggagt taacatcatg aatttattgc acattgttca      960

aaaggaacca ggaggttttt ttgtcaacat tgtgatgtat attcctttga agatagtaac     1020

tgtagatgga aaaacttgtg ctataaagct agatgctttc ctaaatcaga tgttttggtc     1080

aagtagtttg actcagtata ggtagggaga tatttaagta taaaatacaa caaaggaagt     1140

ctaaatattc agaatctttg ttaaggtcct gaaagtaact cataatctat aaacaatgaa     1200

atattgctgt atagctcctt ttgaccttca tttcatgtat agttttccct attgaatcag     1260

tttccaatta tttgacttta atttatgtaa cttgaaccta tgaagcaatg gatatttgta     1320

ctgtttaatg ttctgtgata cagaactctt aaaaatgttt tttcatgtgt tttataaaat     1380

caagttttaa gtgaaagtga ggaaataaag ttaagtttgt tttaaatttg tcttaaaaaa     1440

aaaaaaaaaa aaa                                                        1453


<210>  42
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Ala Leu Gln Leu Ser Arg Glu Gln Gly Ile Thr Leu Arg Gly Ser 
1               5                   10                  15      


Ala Glu Ile Val Ala Glu Phe Phe Ser Phe Gly Ile Asn Ser Ile Leu 
            20                  25                  30          


Tyr Gln Arg Gly Ile Tyr Pro Ser Glu Thr Phe Thr Arg Val Gln Lys 
        35                  40                  45              


Tyr Gly Leu Thr Leu Leu Val Thr Thr Asp Leu Glu Leu Ile Lys Tyr 
    50                  55                  60                  


Leu Asn Asn Val Val Glu Gln Leu Lys Asp Trp Leu Tyr Lys Cys Ser 
65                  70                  75                  80  


Val Gln Lys Leu Val Val Val Ile Ser Asn Ile Glu Ser Gly Glu Val 
                85                  90                  95      


Leu Glu Arg Trp Gln Phe Asp Ile Glu Cys Asp Lys Thr Ala Lys Asp 
            100                 105                 110         


Asp Ser Ala Pro Arg Glu Lys Ser Gln Lys Ala Ile Gln Asp Glu Ile 
        115                 120                 125             


Arg Ser Val Ile Arg Gln Ile Thr Ala Thr Val Thr Phe Leu Pro Leu 
    130                 135                 140                 


Leu Glu Val Ser Cys Ser Phe Asp Leu Leu Ile Tyr Thr Asp Lys Asp 
145                 150                 155                 160 


Leu Val Val Pro Glu Lys Trp Glu Glu Ser Gly Pro Gln Phe Ile Thr 
                165                 170                 175     


Asn Ser Glu Glu Val Arg Leu Arg Ser Phe Thr Thr Thr Ile His Lys 
            180                 185                 190         


Val Asn Ser Met Val Ala Tyr Lys Ile Pro Val Asn Asp 
        195                 200                 205 


