
                                SEQUENCE LISTING

<110> REGENERON PHARMACEUTICALS, INC.

<120> ANTI-EGFRvIII ANTIBODIES AND USES THEREOF
  
<130> A0020WO01

<140> To be assigned      
<141> Filed herewith

<150> 61/950,963
<151> 2014-03-11           

<160> 165

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 1
caggtgcagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtaaaagtc 60
tcctgcaagg cttctggata caccttcacc agttatgata tcaactgggt gcgacaggcc 120
actggacagg ggcttgagtg gatgggatgg attaacccta acagtgatta cacaggctat 180
gtacagaagt tccagggcag agtcaccatg accagggaca cctccataag tacagcctac 240
atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gacatcacgg 300
tggtctgaac acttccacca ctggggccag ggcaccctgg tcactgtctc ctca       354

<210> 2
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 2
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Trp Ile Asn Pro Asn Ser Asp Tyr Thr Gly Tyr Val Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Thr Ser Arg Trp Ser Glu His Phe His His Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 3
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 3
ggatacacct tcaccagtta tgat                                        24

<210> 4
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 4
Gly Tyr Thr Phe Thr Ser Tyr Asp
 1               5              


<210> 5
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 5
attaacccta acagtgatta caca                                        24

<210> 6
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 6
Ile Asn Pro Asn Ser Asp Tyr Thr
 1               5              


<210> 7
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 7
gcgacatcac ggtggtctga acacttccac cac                              33

<210> 8
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 8
Ala Thr Ser Arg Trp Ser Glu His Phe His His
 1               5                  10      


<210> 9
<211> 342
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 9
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc 60
atcaactgca agtccagcca gagtgtttta tacagctcca acaataagaa ctacttagct 120
tggtaccagc acaaaccagg acagcctcct aacctactca tttactgggc atctacccgg 180
gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc 240
atcagcagcc tgcaggctga agatgtggca gtttattact gtcaccaata ttatagtact 300
ccattcactt tcggccctgg gaccaaagtg gatatcaaac ga                    342

<210> 10
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 10
Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly
 1               5                  10                  15      
Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser
            20                  25                  30          
Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln His Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Asn Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys His Gln
                85                  90                  95      
Tyr Tyr Ser Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile
            100                 105                 110         
Lys Arg
        


<210> 11
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 11
cagagtgttt tatacagctc caacaataag aactac                           36

<210> 12
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 12
Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr
 1               5                  10          


<210> 13
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 13
tgggcatct                                                         9

<210> 14
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 14
Trp Ala Ser
 1          


<210> 15
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 15
caccaatatt atagtactcc attcact                                     27

<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 16
His Gln Tyr Tyr Ser Thr Pro Phe Thr
 1               5                  


<210> 17
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 17
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc ccggagactc 60
tcctgtgtag tgtctggatt catcttcagt agctatggca tgcactgggt ccgccaggct 120
ccaggcaagg ggctggagtg ggtggcactt atattttatg atggaagtaa tgaatactat 180
gtagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacactgtat 240
ctccaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gcgagagggc 300
tacagtcagc ggtacaagta ttacttcggt atggacgtct ggggccaagg gaccacggtc 360
accgtctcct ca                                                     372

<210> 18
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 18
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Arg Arg Leu Ser Cys Val Gly Ser Gly Phe Ile Phe Ser Ser Tyr
            20                  25                  30          
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Leu Ile Phe Tyr Asp Gly Ser Asn Glu Tyr Tyr Val Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Tyr Ser Gln Arg Tyr Lys Tyr Tyr Phe Gly Met Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 


<210> 19
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 19
ggattcatct tcagtagcta tggc                                        24

<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 20
Gly Phe Ile Phe Ser Ser Tyr Gly
 1               5              


<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 21
atattttatg atggaagtaa tgaa                                        24

<210> 22
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 22
Ile Phe Tyr Asp Gly Ser Asn Glu
 1               5              


<210> 23
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 23
gcgcgagagg gctacagtca gcggtacaag tattacttcg gtatggacgt c          51

<210> 24
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 24
Ala Arg Glu Gly Tyr Ser Gln Arg Tyr Lys Tyr Tyr Phe Gly Met Asp
 1               5                  10                  15      
Val
    


<210> 25
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 25
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtgggaga cagagtcacc 60
atcacttgtc gggcgagtca gggtattagc agctggttag cctggtatca gcagcaacca 120
gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttacta ttgtcaacag actaacagtt tcccgctcac tttcggcgga 300
gggaccaagg tggagatcaa acga                                        324

<210> 26
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 26
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Gln Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Thr Asn Ser Phe Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 27
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 27
cagggtatta gcagctgg                                               18

<210> 28
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 28
Gln Gly Ile Ser Ser Trp
 1               5      


<210> 29
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 29
gctgcatcc                                                         9

<210> 30
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 30
Ala Ala Ser
 1          


<210> 31
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 31
caacagacta acagtttccc gctcact                                     27

<210> 32
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 32
Gln Gln Thr Asn Ser Phe Pro Leu Thr
 1               5                  


<210> 33
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 33
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt ccccttcagt agctacgaca tgcactgggt ccgccaagct 120
acaggaaaag gtctggagtg ggtctcagct attggtactg ctggtgccac atactatcca 180
ggctccgtga agggccgatt caccatctcc agagaaaatg ccaagaactc cttgtatctt 240
caaatgaaca gcctgagagc cggggacacg gctgtgtatt actgtgcaag aggggattac 300
gtttggggga cttatcgtcc cctctttgac tactggggcc agggaaccct ggtcaccgtc 360
tcctca                                                            366

<210> 34
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 34
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Ser Ser Tyr
            20                  25                  30          
Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Gly Thr Ala Gly Ala Thr Tyr Tyr Pro Gly Ser Val Lys
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Asn Ser Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Gly Asp Tyr Val Trp Gly Thr Tyr Arg Pro Leu Phe Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 35
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 35
ggattcccct tcagtagcta cgac                                        24

<210> 36
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 36
Gly Phe Pro Phe Ser Ser Tyr Asp
 1               5              


<210> 37
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 37
attggtactg ctggtgccac a                                           21

<210> 38
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 38
Ile Gly Thr Ala Gly Ala Thr
 1               5          


<210> 39
<211> 48
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 39
gcaagagggg attacgtttg ggggacttat cgtcccctct ttgactac              48

<210> 40
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 40
Ala Arg Gly Asp Tyr Val Trp Gly Thr Tyr Arg Pro Leu Phe Asp Tyr
 1               5                  10                  15      


<210> 41
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 41
gacatccagt tgacccagtc tccatccttc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgct gggccagtca gggcattaac aattatttag cctggtatca acaaaaacca 120
gggaaagccc ctaagctcct gatctatgct gcatccactt tgcaaactgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtcagcag cttaatagtt acccgctcac tttcggcgga 300
gggaccaagg tggagatcaa a                                           321

<210> 42
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 42
Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Trp Ala Ser Gln Gly Ile Asn Asn Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 43
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 43
cagggcatta acaattat                                               18

<210> 44
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 44
Gln Gly Ile Asn Asn Tyr
 1               5      


<210> 45
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 45
gctgcatcc                                                         9

<210> 46
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 46
Ala Ala Ser
 1          


<210> 47
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 47
cagcagctta atagttaccc gctcact                                     27

<210> 48
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 48
Gln Gln Leu Asn Ser Tyr Pro Leu Thr
 1               5                  


<210> 49
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 49
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cgtctggatt caccttcagt agatatggca tacactgggt ccgccaggct 120
ccaggcaagg ggctggagtg ggtggcagtt atttggcatg atggaagtaa taaatactat 180
gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga ccagcctgag agccgaggac acggctgtgt attactgtgc gagagatgga 300
ctggagatac gagatcacta ctactacggt atggacgtct ggggccaagg gaccacggtc 360
accgtctcct ca                                                     372

<210> 50
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 50
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr
            20                  25                  30          
Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Val Ile Trp His Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Thr Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Gly Leu Glu Ile Arg Asp His Tyr Tyr Tyr Gly Met Asp
            100                 105                 110         
Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 


<210> 51
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 51
ggattcacct tcagtagata tggc                                        24

<210> 52
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 52
Gly Phe Thr Phe Ser Arg Tyr Gly
 1               5              


<210> 53
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 53
atttggcatg atggaagtaa taaa                                        24

<210> 54
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 54
Ile Trp His Asp Gly Ser Asn Lys
 1               5              


<210> 55
<211> 51
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 55
gcgagagatg gactggagat acgagatcac tactactacg gtatggacgt c          51

<210> 56
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 56
Ala Arg Asp Gly Leu Glu Ile Arg Asp His Tyr Tyr Tyr Gly Met Asp
 1               5                  10                  15      
Val
    


<210> 57
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 57
gacatccaga tgacccagtc tccttccacc ctgtctgcat cggtaggaga cagagtcacc 60
atcacttgcc gggccagtca gagtactagt agttggttgg cctggtatca acagaaacca 120
gggaaagccc ctacgctcct gatctataag gcgtctagtt tagaaagtgg ggtcccatca 180
aaattcagcg gcagtggatc tgggacagaa ttcactctca ccatcagcag cctgcagcct 240
gatgattttg caacgtatta ctgccaacag tataacaggt attctcggac gttcggccaa 300
gggaccaagg tggaaattaa a                                           321

<210> 58
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 58
Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Thr Ser Ser Trp
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Thr Leu Leu Ile
        35                  40                  45              
Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Lys Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Arg Tyr Ser Arg
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 59
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 59
cagagtacta gtagttgg                                               18

<210> 60
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 60
Gln Ser Thr Ser Ser Trp
 1               5      


<210> 61
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 61
aaggcgtct                                                         9

<210> 62
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 62
Lys Ala Ser
 1          


<210> 63
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 63
caacagtata acaggtattc tcggacg                                     27

<210> 64
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 64
Gln Gln Tyr Asn Arg Tyr Ser Arg Thr
 1               5                  


<210> 65
<211> 378
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 65
gaagtgcagt tggtggagtc tgggggaggc ttggtacagc ctggcaggtc cctgagactc 60
tcctgtgcag cctctggatt cacctttgat gattatgcca tgcactgggt ccggcaagtt 120
ccagggaagg gcctggagtg ggtctcaggt attagttgga atagtggtag cataggctat 180
gcggactctg tgaagggccg attcaccatc tccagagaca acgccaagaa ctccctgtat 240
ctgcaaatga atagtctgag agctgaggac acggccttgt attactgtgc aaaagatatc 300
catgactacg gaaaagatta ctactactac tacggtatgg acgtctgggg ccaagggacc 360
acggtcaccg tctcctca                                               378

<210> 66
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 66
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr
            20                  25                  30          
Ala Met His Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys
                85                  90                  95      
Ala Lys Asp Ile His Asp Tyr Gly Lys Asp Tyr Tyr Tyr Tyr Tyr Gly
            100                 105                 110         
Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 125     


<210> 67
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 67
ggattcacct ttgatgatta tgcc                                        24

<210> 68
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 68
Gly Phe Thr Phe Asp Asp Tyr Ala
 1               5              


<210> 69
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 69
attagttgga atagtggtag cata                                        24

<210> 70
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 70
Ile Ser Trp Asn Ser Gly Ser Ile
 1               5              


<210> 71
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 71
gcaaaagata tccatgacta cggaaaagat tactactact actacggtat ggacgtc    57

<210> 72
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 72
Ala Lys Asp Ile His Asp Tyr Gly Lys Asp Tyr Tyr Tyr Tyr Tyr Gly
 1               5                  10                  15      
Met Asp Val
            


<210> 73
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 73
gaaattgcgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60
ctctcctgca gggccagtca gagtgttagc agcacctatt tagcctggta ccagcagaaa 120
cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180
gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240
cctgaagatt ttgcagtgta ttactgtcag cagtatgata gttcaccgat caccttcggc 300
caagggacac gactggagat taaa                                        324

<210> 74
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 74
Glu Ile Ala Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Thr
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu
        35                  40                  45              
Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu
65                  70                  75                  80  
Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Pro
                85                  90                  95      
Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys
            100                 105             


<210> 75
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 75
cagagtgtta gcagcaccta t                                           21

<210> 76
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 76
Gln Ser Val Ser Ser Thr Tyr
 1               5          


<210> 77
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 77
ggtgcatcc                                                         9

<210> 78
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 78
Gly Ala Ser
 1          


<210> 79
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 79
cagcagtatg atagttcacc gatcacc                                     27

<210> 80
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 80
Gln Gln Tyr Asp Ser Ser Pro Ile Thr
 1               5                  


<210> 81
<211> 354
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 81
caggtgcagc tggtggaatc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60
tcctgtgcag cgtctggatt caccttcagt gcctatgcca tgcactgggt ccgccaggct 120
ccaggcaagg ggctggagtg ggtggcagtt atatggtatg atggaagtaa taaaaattat 180
gcagactccg tgaagggccg attcaccgtc tccagagaca attccaagaa cacgctgtat 240
ctggaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatcta 300
atggtcggag ttactaacta ttggggccag ggaaccctgg tcaccgtctc caca       354

<210> 82
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 82
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr
            20                  25                  30          
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Val Ile Trp Tyr Asp Gly Ser Asn Lys Asn Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Glu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Leu Met Val Gly Val Thr Asn Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Thr
        115             


<210> 83
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 83
ggattcacct tcagtgccta tgcc                                        24

<210> 84
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 84
Gly Phe Thr Phe Ser Ala Tyr Ala
 1               5              


<210> 85
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 85
atatggtatg atggaagtaa taaa                                        24

<210> 86
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 86
Ile Trp Tyr Asp Gly Ser Asn Lys
 1               5              


<210> 87
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 87
gcgagagatc taatggtcgg agttactaac tat                              33

<210> 88
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 88
Ala Arg Asp Leu Met Val Gly Val Thr Asn Tyr
 1               5                  10      


<210> 89
<211> 339
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 89
gatgttgtga tgactcagtc tccactctcc ctgcccgtcg cccttggaca gccggcctcc 60
atctcctgca ggtctagtca aagcctcgta tacactgatg gaaacaccta cttgaattgg 120
tttcaccaga ggccaggcca atctccaagg cgcctaattt ataaggtttc taaccgggac 180
tctggggtcc cagacagatt caccggcagt gggtcaggca ctgatttcac actaaaaatc 240
agcagggtgg aggctgagga tgttggggtc ttttactgca tgcaaggttc acactggcct 300
ccgtacactt ttggccaggg gaccaagctg gagatcaaa                        339

<210> 90
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 90
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ala Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val Tyr Thr
            20                  25                  30          
Asp Gly Asn Thr Tyr Leu Asn Trp Phe His Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Arg Arg Leu Ile Tyr Lys Val Ser Asn Arg Asp Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Phe Tyr Cys Met Gln Gly
                85                  90                  95      
Ser His Trp Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile
            100                 105                 110         
Lys
    


<210> 91
<211> 33
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 91
caaagcctcg tatacactga tggaaacacc tac                              33

<210> 92
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 92
Gln Ser Leu Val Tyr Thr Asp Gly Asn Thr Tyr
 1               5                  10      


<210> 93
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 93
aaggtttct                                                         9

<210> 94
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 94
Lys Val Ser
 1          


<210> 95
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 95
atgcaaggtt cacactggcc tccgtacact                                  30

<210> 96
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 96
Met Gln Gly Ser His Trp Pro Pro Tyr Thr
 1               5                  10  


<210> 97
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 97
caggttcagc tacagcagtg gggcgcagga ctgttgaagc ctgcggagac cctgtccctc 60
acctgcgctg tctatggtgg atccttcagt ggtaactact ggagctggat ccgccagtcc 120
ccagggaagg ggttggagtg gattggggaa atcaatcatc gtggaaactc caactacaac 180
ccgtccctca agagtcgagg caccatatca ttagacacgt ccaagaacca gttatccctg 240
aagctgaggt ctgtgaccgc cgcggacacg gccatgtatt attgtgtgag agggggtggg 300
gactactact tcggcatgga cgtctggggc caggggacca cggtcaccgt ctcctca    357

<210> 98
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 98
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ala Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Asn
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn His Arg Gly Asn Ser Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Gly Thr Ile Ser Leu Asp Thr Ser Lys Asn Gln Leu Ser Leu
65                  70                  75                  80  
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Met Tyr Tyr Cys Val
                85                  90                  95      
Arg Gly Gly Gly Asp Tyr Tyr Phe Gly Met Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser
        115                 


<210> 99
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 99
ggtggatcct tcagtggtaa ctac                                        24

<210> 100
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 100
Gly Gly Ser Phe Ser Gly Asn Tyr
 1               5              


<210> 101
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 101
atcaatcatc gtggaaactc c                                           21

<210> 102
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 102
Ile Asn His Arg Gly Asn Ser
 1               5          


<210> 103
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 103
gtgagagggg gtggggacta ctacttcggc atggacgtc                        39

<210> 104
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 104
Val Arg Gly Gly Gly Asp Tyr Tyr Phe Gly Met Asp Val
 1               5                  10              


<210> 105
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 105
gccatccagt tgacccagtc tccatcctcc ctgtctgcgt ctgtaggaga cagagtcacc 60
atcacttgcc gggcaagtca gggcattgga aatgatttag gctggtatca gctgagacca 120
gggaaagccc ctaaactcct gatctatgct acatccagtt tacaaagtgg ggtcccatca 180
aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtctacaa gattacaatt atccgtggac gttcggccaa 300
gggaccaagg tggaaatcaa g                                           321

<210> 106
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 106
Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Asn Asp
            20                  25                  30          
Leu Gly Trp Tyr Gln Leu Arg Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 107
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 107
cagggcattg gaaatgat                                               18

<210> 108
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 108
Gln Gly Ile Gly Asn Asp
 1               5      


<210> 109
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 109
gctacatcc                                                         9

<210> 110
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 110
Ala Thr Ser
 1          


<210> 111
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 111
ctacaagatt acaattatcc gtggacg                                     27

<210> 112
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 112
Leu Gln Asp Tyr Asn Tyr Pro Trp Thr
 1               5                  


<210> 113
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 113
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60
acctgcgctg tctatggagg gtccttcagt ggttactact ggagctggat ccgccagtcc 120
ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac 180
ccgtccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240
aagttgacct ctgtgaccgc cgcggacacg gctgtatatt tctgtgcgag agggggtggg 300
acctactact acggtatgga cgtttggggc caagggacca cggtcaccgt ctcctca    357

<210> 114
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 114
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Thr Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala
                85                  90                  95      
Arg Gly Gly Gly Thr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser
        115                 


<210> 115
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 115
ggagggtcct tcagtggtta ctac                                        24

<210> 116
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 116
Gly Gly Ser Phe Ser Gly Tyr Tyr
 1               5              


<210> 117
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 117
atcaatcata gtggaagcac c                                           21

<210> 118
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 118
Ile Asn His Ser Gly Ser Thr
 1               5          


<210> 119
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 119
gcgagagggg gtgggaccta ctactacggt atggacgtt                        39

<210> 120
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 120
Ala Arg Gly Gly Gly Thr Tyr Tyr Tyr Gly Met Asp Val
 1               5                  10              


<210> 121
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 121
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgcc gggcaagtca gggcattgga tatgatttag gctggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatgct gcatccagtt tacaaagtgg ggtcccatca 180
aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtctacag gattacaatt acccgtggac gttcggccaa 300
gggaccaagg tggatatcaa a                                           321

<210> 122
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 122
Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Tyr Asp
            20                  25                  30          
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
            100                 105         


<210> 123
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 123
cagggcattg gatatgat                                               18

<210> 124
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 124
Gln Gly Ile Gly Tyr Asp
 1               5      


<210> 125
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 125
gctgcatcc                                                         9

<210> 126
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 126
Ala Ala Ser
 1          


<210> 127
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 127
ctacaggatt acaattaccc gtggacg                                     27

<210> 128
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 128
Leu Gln Asp Tyr Asn Tyr Pro Trp Thr
 1               5                  


<210> 129
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 129
caggtgcagc tacagcagtg gggcgcagga ctgttgaagc cttcggagac cctgtccctc 60
acctgcgctg tctatggtgg atccttcagt ggtgactact ggagctggat tcgccagtcc 120
ccagggaagg ggctggagtg gattggggaa atcaatcata gtggaagcac caactacaac 180
ccgtccctca agagtcgagt caccatatca atagacacgt ccaagaacca gttctccctg 240
aaactgagct ctgtgaccgc cgcggacacg gctgtgtatt actgtgcgag aggaggcggg 300
gactactact acggtatgga cgtctggggc ctagggacca cggtcaccgt ctcctca    357

<210> 130
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 130
Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Asp
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Asn His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Ile Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Gly Gly Gly Asp Tyr Tyr Tyr Gly Met Asp Val Trp Gly Leu Gly
            100                 105                 110         
Thr Thr Val Thr Val Ser Ser
        115                 


<210> 131
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 131
ggtggatcct tcagtggtga ctac                                        24

<210> 132
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 132
Gly Gly Ser Phe Ser Gly Asp Tyr
 1               5              


<210> 133
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 133
atcaatcata gtggaagcac c                                           21

<210> 134
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 134
Ile Asn His Ser Gly Ser Thr
 1               5          


<210> 135
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 135
gcgagaggag gcggggacta ctactacggt atggacgtc                        39

<210> 136
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 136
Ala Arg Gly Gly Gly Asp Tyr Tyr Tyr Gly Met Asp Val
 1               5                  10              


<210> 137
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 137
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgcc gggcaagtca gggcattgga aatgatttag gctggtatca gcagaaacca 120
gggaaagccc ctaacctcct gatctatgct acatccagtt tacaaagtgg ggtcccatca 180
aggttcagcg gcagtggatc tggcacagat ttcactctca ccatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtctacaa gattacaatt acccgtggac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 138
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 138
Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Asn Asp
            20                  25                  30          
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Leu Ile
        35                  40                  45              
Tyr Ala Thr Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 139
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 139
cagggcattg gaaatgat                                               18

<210> 140
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 140
Gln Gly Ile Gly Asn Asp
 1               5      


<210> 141
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 141
gctacatcc                                                         9

<210> 142
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 142
Ala Thr Ser
 1          


<210> 143
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 143
ctacaagatt acaattaccc gtggacg                                     27

<210> 144
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 144
Leu Gln Asp Tyr Asn Tyr Pro Trp Thr
 1               5                  


<210> 145
<211> 3633
<212> DNA
<213> Homo sapiens

<400> 145
atgcgaccct ccgggacggc cggggcagcg ctcctggcgc tgctggctgc gctctgcccg 60
gcgagtcggg ctctggagga aaagaaagtt tgccaaggca cgagtaacaa gctcacgcag 120
ttgggcactt ttgaagatca ttttctcagc ctccagagga tgttcaataa ctgtgaggtg 180
gtccttggga atttggaaat tacctatgtg cagaggaatt atgatctttc cttcttaaag 240
accatccagg aggtggctgg ttatgtcctc attgccctca acacagtgga gcgaattcct 300
ttggaaaacc tgcagatcat cagaggaaat atgtactacg aaaattccta tgccttagca 360
gtcttatcta actatgatgc aaataaaacc ggactgaagg agctgcccat gagaaattta 420
caggaaatcc tgcatggcgc cgtgcggttc agcaacaacc ctgccctgtg caacgtggag 480
agcatccagt ggcgggacat agtcagcagt gactttctca gcaacatgtc gatggacttc 540
cagaaccacc tgggcagctg ccaaaagtgt gatccaagct gtcccaatgg gagctgctgg 600
ggtgcaggag aggagaactg ccagaaactg accaaaatca tctgtgccca gcagtgctcc 660
gggcgctgcc gtggcaagtc ccccagtgac tgctgccaca accagtgtgc tgcaggctgc 720
acaggccccc gggagagcga ctgcctggtc tgccgcaaat tccgagacga agccacgtgc 780
aaggacacct gccccccact catgctctac aaccccacca cgtaccagat ggatgtgaac 840
cccgagggca aatacagctt tggtgccacc tgcgtgaaga agtgtccccg taattatgtg 900
gtgacagatc acggctcgtg cgtccgagcc tgtggggccg acagctatga gatggaggaa 960
gacggcgtcc gcaagtgtaa gaagtgcgaa gggccttgcc gcaaagtgtg taacggaata 1020
ggtattggtg aatttaaaga ctcactctcc ataaatgcta cgaatattaa acacttcaaa 1080
aactgcacct ccatcagtgg cgatctccac atcctgccgg tggcatttag gggtgactcc 1140
ttcacacata ctcctcctct ggatccacag gaactggata ttctgaaaac cgtaaaggaa 1200
atcacagggt ttttgctgat tcaggcttgg cctgaaaaca ggacggacct ccatgccttt 1260
gagaacctag aaatcatacg cggcaggacc aagcaacatg gtcagttttc tcttgcagtc 1320
gtcagcctga acataacatc cttgggatta cgctccctca aggagataag tgatggagat 1380
gtgataattt caggaaacaa aaatttgtgc tatgcaaata caataaactg gaaaaaactg 1440
tttgggacct ccggtcagaa aaccaaaatt ataagcaaca gaggtgaaaa cagctgcaag 1500
gccacaggcc aggtctgcca tgccttgtgc tcccccgagg gctgctgggg cccggagccc 1560
agggactgcg tctcttgccg gaatgtcagc cgaggcaggg aatgcgtgga caagtgcaac 1620
cttctggagg gtgagccaag ggagtttgtg gagaactctg agtgcataca gtgccaccca 1680
gagtgcctgc ctcaggccat gaacatcacc tgcacaggac ggggaccaga caactgtatc 1740
cagtgtgccc actacattga cggcccccac tgcgtcaaga cctgcccggc aggagtcatg 1800
ggagaaaaca acaccctggt ctggaagtac gcagacgccg gccatgtgtg ccacctgtgc 1860
catccaaact gcacctacgg atgcactggg ccaggtcttg aaggctgtcc aacgaatggg 1920
cctaagatcc cgtccatcgc cactgggatg gtgggggccc tcctcttgct gctggtggtg 1980
gccctgggga tcggcctctt catgcgaagg cgccacatcg ttcggaagcg cacgctgcgg 2040
aggctgctgc aggagaggga gcttgtggag cctcttacac ccagtggaga agctcccaac 2100
caagctctct tgaggatctt gaaggaaact gaattcaaaa agatcaaagt gctgggctcc 2160
ggtgcgttcg gcacggtgta taagggactc tggatcccag aaggtgagaa agttaaaatt 2220
cccgtcgcta tcaaggaatt aagagaagca acatctccga aagccaacaa ggaaatcctc 2280
gatgaagcct acgtgatggc cagcgtggac aacccccacg tgtgccgcct gctgggcatc 2340
tgcctcacct ccaccgtgca gctcatcacg cagctcatgc ccttcggctg cctcctggac 2400
tatgtccggg aacacaaaga caatattggc tcccagtacc tgctcaactg gtgtgtgcag 2460
atcgcaaagg gcatgaacta cttggaggac cgtcgcttgg tgcaccgcga cctggcagcc 2520
aggaacgtac tggtgaaaac accgcagcat gtcaagatca cagattttgg gctggccaaa 2580
ctgctgggtg cggaagagaa agaataccat gcagaaggag gcaaagtgcc tatcaagtgg 2640
atggcattgg aatcaatttt acacagaatc tatacccacc agagtgatgt ctggagctac 2700
ggggtgactg tttgggagtt gatgaccttt ggatccaagc catatgacgg aatccctgcc 2760
agcgagatct cctccatcct ggagaaagga gaacgcctcc ctcagccacc catatgtacc 2820
atcgatgtct acatgatcat ggtcaagtgc tggatgatag acgcagatag tcgcccaaag 2880
ttccgtgagt tgatcatcga attctccaaa atggcccgag acccccagcg ctaccttgtc 2940
attcaggggg atgaaagaat gcatttgcca agtcctacag actccaactt ctaccgtgcc 3000
ctgatggatg aagaagacat ggacgacgtg gtggatgccg acgagtacct catcccacag 3060
cagggcttct tcagcagccc ctccacgtca cggactcccc tcctgagctc tctgagtgca 3120
accagcaaca attccaccgt ggcttgcatt gatagaaatg ggctgcaaag ctgtcccatc 3180
aaggaagaca gcttcttgca gcgatacagc tcagacccca caggcgcctt gactgaggac 3240
agcatagacg acaccttcct cccagtgcct gaatacataa accagtccgt tcccaaaagg 3300
cccgctggct ctgtgcagaa tcctgtctat cacaatcagc ctctgaaccc cgcgcccagc 3360
agagacccac actaccagga cccccacagc actgcagtgg gcaaccccga gtatctcaac 3420
actgtccagc ccacctgtgt caacagcaca ttcgacagcc ctgcccactg ggcccagaaa 3480
ggcagccacc aaattagcct ggacaaccct gactaccagc aggacttctt tcccaaggaa 3540
gccaagccaa atggcatctt taagggctcc acagctgaaa atgcagaata cctaagggtc 3600
gcgccacaaa gcagtgaatt tattggagca tga                              3633

<210> 146
<211> 1210
<212> PRT
<213> Homo sapiens

<400> 146
Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala
 1               5                  10                  15      
Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln
            20                  25                  30          
Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe
        35                  40                  45              
Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn
    50                  55                  60                  
Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys
65                  70                  75                  80  
Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val
                85                  90                  95      
Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr
            100                 105                 110         
Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn
        115                 120                 125             
Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu
    130                 135                 140                 
His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu
145                 150                 155                 160 
Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met
                165                 170                 175     
Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro
            180                 185                 190         
Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln
        195                 200                 205             
Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg
    210                 215                 220                 
Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys
225                 230                 235                 240 
Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp
                245                 250                 255     
Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro
            260                 265                 270         
Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly
        275                 280                 285             
Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His
    290                 295                 300                 
Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu
305                 310                 315                 320 
Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val
                325                 330                 335     
Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn
            340                 345                 350         
Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp
        355                 360                 365             
Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr
    370                 375                 380                 
Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu
385                 390                 395                 400 
Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp
                405                 410                 415     
Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln
            420                 425                 430         
His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu
        435                 440                 445             
Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser
    450                 455                 460                 
Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu
465                 470                 475                 480 
Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu
                485                 490                 495     
Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro
            500                 505                 510         
Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn
        515                 520                 525             
Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly
    530                 535                 540                 
Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro
545                 550                 555                 560 
Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro
                565                 570                 575     
Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val
            580                 585                 590         
Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp
        595                 600                 605             
Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys
    610                 615                 620                 
Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly
625                 630                 635                 640 
Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val Gly Ala Leu Leu Leu
                645                 650                 655     
Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe Met Arg Arg Arg His
            660                 665                 670         
Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu Gln Glu Arg Glu Leu
        675                 680                 685             
Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro Asn Gln Ala Leu Leu
    690                 695                 700                 
Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile Lys Val Leu Gly Ser
705                 710                 715                 720 
Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp Ile Pro Glu Gly Glu
                725                 730                 735     
Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu Arg Glu Ala Thr Ser
            740                 745                 750         
Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala Tyr Val Met Ala Ser
        755                 760                 765             
Val Asp Asn Pro His Val Cys Arg Leu Leu Gly Ile Cys Leu Thr Ser
    770                 775                 780                 
Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe Gly Cys Leu Leu Asp
785                 790                 795                 800 
Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser Gln Tyr Leu Leu Asn
                805                 810                 815     
Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr Leu Glu Asp Arg Arg
            820                 825                 830         
Leu Val His Arg Asp Leu Ala Ala Arg Asn Val Leu Val Lys Thr Pro
        835                 840                 845             
Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala Lys Leu Leu Gly Ala
    850                 855                 860                 
Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys Val Pro Ile Lys Trp
865                 870                 875                 880 
Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr Thr His Gln Ser Asp
                885                 890                 895     
Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu Met Thr Phe Gly Ser
            900                 905                 910         
Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile Ser Ser Ile Leu Glu
        915                 920                 925             
Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr
    930                 935                 940                 
Met Ile Met Val Lys Cys Trp Met Ile Asp Ala Asp Ser Arg Pro Lys
945                 950                 955                 960 
Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met Ala Arg Asp Pro Gln
                965                 970                 975     
Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met His Leu Pro Ser Pro
            980                 985                 990         
Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp Glu Glu Asp Met Asp
        995                 1000                1005            
Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro Gln Gln Gly Phe Phe
    1010                1015                1020                
Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu Ser Ser Leu Ser Ala
1025                1030                1035               1040 
Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp Arg Asn Gly Leu Gln
                1045                1050                1055    
Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln Arg Tyr Ser Ser Asp
            1060                1065                1070        
Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp Asp Thr Phe Leu Pro
        1075                1080                1085            
Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys Arg Pro Ala Gly Ser
    1090                1095                1100                
Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu Asn Pro Ala Pro Ser
1105                1110                1115               1120 
Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr Ala Val Gly Asn Pro
                1125                1130                1135    
Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val Asn Ser Thr Phe Asp
            1140                1145                1150        
Ser Pro Ala His Trp Ala Gln Lys Gly Ser His Gln Ile Ser Leu Asp
        1155                1160                1165            
Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys Glu Ala Lys Pro Asn
    1170                1175                1180                
Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala Glu Tyr Leu Arg Val
1185                1190                1195               1200 
Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala
                1205                1210


<210> 147
<211> 943
<212> PRT
<213> Homo sapiens

<400> 147
Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala
 1               5                  10                  15      
Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly Asn Tyr
            20                  25                  30          
Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser
        35                  40                  45              
Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly
    50                  55                  60                  
Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp
65                  70                  75                  80  
Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr
                85                  90                  95      
Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp
            100                 105                 110         
Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu
        115                 120                 125             
Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro
    130                 135                 140                 
Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg
145                 150                 155                 160 
Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu
                165                 170                 175     
Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly
            180                 185                 190         
Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile
        195                 200                 205             
Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile
    210                 215                 220                 
Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His
225                 230                 235                 240 
Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys
                245                 250                 255     
Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys
            260                 265                 270         
Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys
        275                 280                 285             
Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys
    290                 295                 300                 
Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp
305                 310                 315                 320 
Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn
                325                 330                 335     
Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu
            340                 345                 350         
Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly
        355                 360                 365             
Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Thr Gly Met Val
    370                 375                 380                 
Gly Ala Leu Leu Leu Leu Leu Val Val Ala Leu Gly Ile Gly Leu Phe
385                 390                 395                 400 
Met Arg Arg Arg His Ile Val Arg Lys Arg Thr Leu Arg Arg Leu Leu
                405                 410                 415     
Gln Glu Arg Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Glu Ala Pro
            420                 425                 430         
Asn Gln Ala Leu Leu Arg Ile Leu Lys Glu Thr Glu Phe Lys Lys Ile
        435                 440                 445             
Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Leu Trp
    450                 455                 460                 
Ile Pro Glu Gly Glu Lys Val Lys Ile Pro Val Ala Ile Lys Glu Leu
465                 470                 475                 480 
Arg Glu Ala Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala
                485                 490                 495     
Tyr Val Met Ala Ser Val Asp Asn Pro His Val Cys Arg Leu Leu Gly
            500                 505                 510         
Ile Cys Leu Thr Ser Thr Val Gln Leu Ile Thr Gln Leu Met Pro Phe
        515                 520                 525             
Gly Cys Leu Leu Asp Tyr Val Arg Glu His Lys Asp Asn Ile Gly Ser
    530                 535                 540                 
Gln Tyr Leu Leu Asn Trp Cys Val Gln Ile Ala Lys Gly Met Asn Tyr
545                 550                 555                 560 
Leu Glu Asp Arg Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val
                565                 570                 575     
Leu Val Lys Thr Pro Gln His Val Lys Ile Thr Asp Phe Gly Leu Ala
            580                 585                 590         
Lys Leu Leu Gly Ala Glu Glu Lys Glu Tyr His Ala Glu Gly Gly Lys
        595                 600                 605             
Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu His Arg Ile Tyr
    610                 615                 620                 
Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu
625                 630                 635                 640 
Met Thr Phe Gly Ser Lys Pro Tyr Asp Gly Ile Pro Ala Ser Glu Ile
                645                 650                 655     
Ser Ser Ile Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys
            660                 665                 670         
Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ala
        675                 680                 685             
Asp Ser Arg Pro Lys Phe Arg Glu Leu Ile Ile Glu Phe Ser Lys Met
    690                 695                 700                 
Ala Arg Asp Pro Gln Arg Tyr Leu Val Ile Gln Gly Asp Glu Arg Met
705                 710                 715                 720 
His Leu Pro Ser Pro Thr Asp Ser Asn Phe Tyr Arg Ala Leu Met Asp
                725                 730                 735     
Glu Glu Asp Met Asp Asp Val Val Asp Ala Asp Glu Tyr Leu Ile Pro
            740                 745                 750         
Gln Gln Gly Phe Phe Ser Ser Pro Ser Thr Ser Arg Thr Pro Leu Leu
        755                 760                 765             
Ser Ser Leu Ser Ala Thr Ser Asn Asn Ser Thr Val Ala Cys Ile Asp
    770                 775                 780                 
Arg Asn Gly Leu Gln Ser Cys Pro Ile Lys Glu Asp Ser Phe Leu Gln
785                 790                 795                 800 
Arg Tyr Ser Ser Asp Pro Thr Gly Ala Leu Thr Glu Asp Ser Ile Asp
                805                 810                 815     
Asp Thr Phe Leu Pro Val Pro Glu Tyr Ile Asn Gln Ser Val Pro Lys
            820                 825                 830         
Arg Pro Ala Gly Ser Val Gln Asn Pro Val Tyr His Asn Gln Pro Leu
        835                 840                 845             
Asn Pro Ala Pro Ser Arg Asp Pro His Tyr Gln Asp Pro His Ser Thr
    850                 855                 860                 
Ala Val Gly Asn Pro Glu Tyr Leu Asn Thr Val Gln Pro Thr Cys Val
865                 870                 875                 880 
Asn Ser Thr Phe Asp Ser Pro Ala His Trp Ala Gln Lys Gly Ser His
                885                 890                 895     
Gln Ile Ser Leu Asp Asn Pro Asp Tyr Gln Gln Asp Phe Phe Pro Lys
            900                 905                 910         
Glu Ala Lys Pro Asn Gly Ile Phe Lys Gly Ser Thr Ala Glu Asn Ala
        915                 920                 925             
Glu Tyr Leu Arg Val Ala Pro Gln Ser Ser Glu Phe Ile Gly Ala
    930                 935                 940             


<210> 148
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 148
Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His
 1               5                  10              


<210> 149
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 149
Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr Asp His Gly Gly Gly
 1               5                  10                  15      
Gly Ser Lys
            


<210> 150
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 150
Gly Gly Gly Gly Ser Leu Glu Glu Lys Lys Gly Asn Tyr Val Val Thr
 1               5                  10                  15      
Asp His
        


<210> 151
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 151
Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys
 1               5                  10                  15      
Gly Gly Gly Gly Ser Lys
            20          


<210> 152
<211> 408
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 152
Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala
 1               5                  10                  15      
Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly Asn Tyr
            20                  25                  30          
Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser
        35                  40                  45              
Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly
    50                  55                  60                  
Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp
65                  70                  75                  80  
Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr
                85                  90                  95      
Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp
            100                 105                 110         
Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu
        115                 120                 125             
Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro
    130                 135                 140                 
Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg
145                 150                 155                 160 
Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu
                165                 170                 175     
Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly
            180                 185                 190         
Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile
        195                 200                 205             
Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile
    210                 215                 220                 
Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His
225                 230                 235                 240 
Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys
                245                 250                 255     
Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys
            260                 265                 270         
Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys
        275                 280                 285             
Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys
    290                 295                 300                 
Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp
305                 310                 315                 320 
Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn
                325                 330                 335     
Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu
            340                 345                 350         
Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly
        355                 360                 365             
Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Glu Gln Lys Leu
    370                 375                 380                 
Ile Ser Glu Glu Asp Leu Gly Gly Glu Gln Lys Leu Ile Ser Glu Glu
385                 390                 395                 400 
Asp Leu His His His His His His
                405             


<210> 153
<211> 613
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 153
Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala
 1               5                  10                  15      
Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Gly Asn Tyr
            20                  25                  30          
Val Val Thr Asp His Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser
        35                  40                  45              
Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly
    50                  55                  60                  
Pro Cys Arg Lys Val Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp
65                  70                  75                  80  
Ser Leu Ser Ile Asn Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr
                85                  90                  95      
Ser Ile Ser Gly Asp Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp
            100                 105                 110         
Ser Phe Thr His Thr Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu
        115                 120                 125             
Lys Thr Val Lys Glu Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro
    130                 135                 140                 
Glu Asn Arg Thr Asp Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg
145                 150                 155                 160 
Gly Arg Thr Lys Gln His Gly Gln Phe Ser Leu Ala Val Val Ser Leu
                165                 170                 175     
Asn Ile Thr Ser Leu Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly
            180                 185                 190         
Asp Val Ile Ile Ser Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile
        195                 200                 205             
Asn Trp Lys Lys Leu Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile
    210                 215                 220                 
Ser Asn Arg Gly Glu Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His
225                 230                 235                 240 
Ala Leu Cys Ser Pro Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys
                245                 250                 255     
Val Ser Cys Arg Asn Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys
            260                 265                 270         
Asn Leu Leu Glu Gly Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys
        275                 280                 285             
Ile Gln Cys His Pro Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys
    290                 295                 300                 
Thr Gly Arg Gly Pro Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp
305                 310                 315                 320 
Gly Pro His Cys Val Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn
                325                 330                 335     
Asn Thr Leu Val Trp Lys Tyr Ala Asp Ala Gly His Val Cys His Leu
            340                 345                 350         
Cys His Pro Asn Cys Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly
        355                 360                 365             
Cys Pro Thr Asn Gly Pro Lys Ile Pro Ser Ile Ala Glu Pro Arg Gly
    370                 375                 380                 
Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu
385                 390                 395                 400 
Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val
                405                 410                 415     
Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val
            420                 425                 430         
Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val
        435                 440                 445             
Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser
    450                 455                 460                 
Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met
465                 470                 475                 480 
Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala
                485                 490                 495     
Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro
            500                 505                 510         
Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln
        515                 520                 525             
Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr
    530                 535                 540                 
Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr
545                 550                 555                 560 
Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu
                565                 570                 575     
Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser
            580                 585                 590         
Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser
        595                 600                 605             
Arg Thr Pro Gly Lys
    610             


<210> 154
<211> 684
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 154
Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala
 1               5                  10                  15      
Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln
            20                  25                  30          
Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe
        35                  40                  45              
Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn
    50                  55                  60                  
Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys
65                  70                  75                  80  
Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val
                85                  90                  95      
Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr
            100                 105                 110         
Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn
        115                 120                 125             
Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu
    130                 135                 140                 
His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu
145                 150                 155                 160 
Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met
                165                 170                 175     
Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro
            180                 185                 190         
Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln
        195                 200                 205             
Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg
    210                 215                 220                 
Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys
225                 230                 235                 240 
Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp
                245                 250                 255     
Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro
            260                 265                 270         
Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly
        275                 280                 285             
Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His
    290                 295                 300                 
Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu
305                 310                 315                 320 
Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val
                325                 330                 335     
Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn
            340                 345                 350         
Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp
        355                 360                 365             
Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr
    370                 375                 380                 
Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu
385                 390                 395                 400 
Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp
                405                 410                 415     
Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln
            420                 425                 430         
His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu
        435                 440                 445             
Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser
    450                 455                 460                 
Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu
465                 470                 475                 480 
Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu
                485                 490                 495     
Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro
            500                 505                 510         
Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn
        515                 520                 525             
Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly
    530                 535                 540                 
Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro
545                 550                 555                 560 
Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro
                565                 570                 575     
Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val
            580                 585                 590         
Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp
        595                 600                 605             
Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys
    610                 615                 620                 
Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly
625                 630                 635                 640 
Pro Lys Ile Pro Ser Ile Ala Cys Pro Gly Gly Glu Gln Lys Leu Ile
                645                 650                 655     
Ser Glu Glu Asp Leu Gly Gly Glu Gln Lys Leu Ile Ser Glu Glu Asp
            660                 665                 670         
Leu Ser Gly His His His His His His Ser Ser Gly
        675                 680                 


<210> 155
<211> 880
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 155
Met Arg Pro Ser Gly Thr Ala Gly Ala Ala Leu Leu Ala Leu Leu Ala
 1               5                  10                  15      
Ala Leu Cys Pro Ala Ser Arg Ala Leu Glu Glu Lys Lys Val Cys Gln
            20                  25                  30          
Gly Thr Ser Asn Lys Leu Thr Gln Leu Gly Thr Phe Glu Asp His Phe
        35                  40                  45              
Leu Ser Leu Gln Arg Met Phe Asn Asn Cys Glu Val Val Leu Gly Asn
    50                  55                  60                  
Leu Glu Ile Thr Tyr Val Gln Arg Asn Tyr Asp Leu Ser Phe Leu Lys
65                  70                  75                  80  
Thr Ile Gln Glu Val Ala Gly Tyr Val Leu Ile Ala Leu Asn Thr Val
                85                  90                  95      
Glu Arg Ile Pro Leu Glu Asn Leu Gln Ile Ile Arg Gly Asn Met Tyr
            100                 105                 110         
Tyr Glu Asn Ser Tyr Ala Leu Ala Val Leu Ser Asn Tyr Asp Ala Asn
        115                 120                 125             
Lys Thr Gly Leu Lys Glu Leu Pro Met Arg Asn Leu Gln Glu Ile Leu
    130                 135                 140                 
His Gly Ala Val Arg Phe Ser Asn Asn Pro Ala Leu Cys Asn Val Glu
145                 150                 155                 160 
Ser Ile Gln Trp Arg Asp Ile Val Ser Ser Asp Phe Leu Ser Asn Met
                165                 170                 175     
Ser Met Asp Phe Gln Asn His Leu Gly Ser Cys Gln Lys Cys Asp Pro
            180                 185                 190         
Ser Cys Pro Asn Gly Ser Cys Trp Gly Ala Gly Glu Glu Asn Cys Gln
        195                 200                 205             
Lys Leu Thr Lys Ile Ile Cys Ala Gln Gln Cys Ser Gly Arg Cys Arg
    210                 215                 220                 
Gly Lys Ser Pro Ser Asp Cys Cys His Asn Gln Cys Ala Ala Gly Cys
225                 230                 235                 240 
Thr Gly Pro Arg Glu Ser Asp Cys Leu Val Cys Arg Lys Phe Arg Asp
                245                 250                 255     
Glu Ala Thr Cys Lys Asp Thr Cys Pro Pro Leu Met Leu Tyr Asn Pro
            260                 265                 270         
Thr Thr Tyr Gln Met Asp Val Asn Pro Glu Gly Lys Tyr Ser Phe Gly
        275                 280                 285             
Ala Thr Cys Val Lys Lys Cys Pro Arg Asn Tyr Val Val Thr Asp His
    290                 295                 300                 
Gly Ser Cys Val Arg Ala Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu
305                 310                 315                 320 
Asp Gly Val Arg Lys Cys Lys Lys Cys Glu Gly Pro Cys Arg Lys Val
                325                 330                 335     
Cys Asn Gly Ile Gly Ile Gly Glu Phe Lys Asp Ser Leu Ser Ile Asn
            340                 345                 350         
Ala Thr Asn Ile Lys His Phe Lys Asn Cys Thr Ser Ile Ser Gly Asp
        355                 360                 365             
Leu His Ile Leu Pro Val Ala Phe Arg Gly Asp Ser Phe Thr His Thr
    370                 375                 380                 
Pro Pro Leu Asp Pro Gln Glu Leu Asp Ile Leu Lys Thr Val Lys Glu
385                 390                 395                 400 
Ile Thr Gly Phe Leu Leu Ile Gln Ala Trp Pro Glu Asn Arg Thr Asp
                405                 410                 415     
Leu His Ala Phe Glu Asn Leu Glu Ile Ile Arg Gly Arg Thr Lys Gln
            420                 425                 430         
His Gly Gln Phe Ser Leu Ala Val Val Ser Leu Asn Ile Thr Ser Leu
        435                 440                 445             
Gly Leu Arg Ser Leu Lys Glu Ile Ser Asp Gly Asp Val Ile Ile Ser
    450                 455                 460                 
Gly Asn Lys Asn Leu Cys Tyr Ala Asn Thr Ile Asn Trp Lys Lys Leu
465                 470                 475                 480 
Phe Gly Thr Ser Gly Gln Lys Thr Lys Ile Ile Ser Asn Arg Gly Glu
                485                 490                 495     
Asn Ser Cys Lys Ala Thr Gly Gln Val Cys His Ala Leu Cys Ser Pro
            500                 505                 510         
Glu Gly Cys Trp Gly Pro Glu Pro Arg Asp Cys Val Ser Cys Arg Asn
        515                 520                 525             
Val Ser Arg Gly Arg Glu Cys Val Asp Lys Cys Asn Leu Leu Glu Gly
    530                 535                 540                 
Glu Pro Arg Glu Phe Val Glu Asn Ser Glu Cys Ile Gln Cys His Pro
545                 550                 555                 560 
Glu Cys Leu Pro Gln Ala Met Asn Ile Thr Cys Thr Gly Arg Gly Pro
                565                 570                 575     
Asp Asn Cys Ile Gln Cys Ala His Tyr Ile Asp Gly Pro His Cys Val
            580                 585                 590         
Lys Thr Cys Pro Ala Gly Val Met Gly Glu Asn Asn Thr Leu Val Trp
        595                 600                 605             
Lys Tyr Ala Asp Ala Gly His Val Cys His Leu Cys His Pro Asn Cys
    610                 615                 620                 
Thr Tyr Gly Cys Thr Gly Pro Gly Leu Glu Gly Cys Pro Thr Asn Gly
625                 630                 635                 640 
Pro Lys Ile Pro Ser Ile Ala Glu Pro Arg Gly Pro Thr Ile Lys Pro
                645                 650                 655     
Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser
            660                 665                 670         
Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu
        675                 680                 685             
Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro
    690                 695                 700                 
Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala
705                 710                 715                 720 
Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val
                725                 730                 735     
Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe
            740                 745                 750         
Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr
        755                 760                 765             
Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu
    770                 775                 780                 
Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys
785                 790                 795                 800 
Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn
                805                 810                 815     
Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp
            820                 825                 830         
Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys
        835                 840                 845             
Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly
    850                 855                 860                 
Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys
865                 870                 875                 880 


<210> 156
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 156
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 157
<211> 327
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 157
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys
                325         


<210> 158
<211> 327
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 158
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg
 1               5                  10                  15      
Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr
65                  70                  75                  80  
Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro
            100                 105                 110         
Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys
        115                 120                 125             
Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val
    130                 135                 140                 
Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp
145                 150                 155                 160 
Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe
                165                 170                 175     
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp
            180                 185                 190         
Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu
        195                 200                 205             
Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg
    210                 215                 220                 
Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys
225                 230                 235                 240 
Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp
                245                 250                 255     
Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys
            260                 265                 270         
Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser
        275                 280                 285             
Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser
    290                 295                 300                 
Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
305                 310                 315                 320 
Leu Ser Leu Ser Leu Gly Lys
                325         


<210> 159
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> (1)...(1)
<223> Xaa = Ala

<220> 
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Arg or Lys

<220> 
<221> VARIANT        
<222> (3)...(3)
<223> Xaa = Gly or Asp

<220> 
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = Asp, Gly, Ile or absent


<220> 
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = Tyr, Leu, His or absent


<220> 
<221> VARIANT        
<222> (6)...(6)
<223> Xaa = Val, Glu, Asp, Met or absent


<220> 
<221> VARIANT        
<222> (7)...(7)
<223> Xaa = Trp, Ile, Tyr, Val or absent


<220> 
<221> VARIANT        
<222> (8)...(8)
<223> Xaa = Gly or Arg


<220> 
<221> VARIANT        
<222> (9)...(9)
<223> Xaa = Thr, Asp, Lys, Gly or Val


<220> 
<221> VARIANT        
<222> (10)...(10)
<223> Xaa = His, Asp, Thr or absent


<220> 
<221> VARIANT        
<222> (11)...(11)
<223> Xaa = Tyr or absent


<220> 
<221> VARIANT        
<222> (12)...(12)
<223> Xaa = Tyr or absent


<220> 
<221> VARIANT        
<222> (13)...(13)
<223> Xaa = Tyr or Asn


<220> 
<221> VARIANT        
<222> (14)...(14)
<223> Xaa = Arg or Tyr


<220> 
<221> VARIANT        
<222> (15)...(15)
<223> Xaa = Pro, Tyr or absent


<220> 
<221> VARIANT        
<222> (16)...(16)
<223> Xaa = Leu, Gly or absent


<220> 
<221> VARIANT        
<222> (17)...(17)
<223> Xaa = Phe, Met or absent


<220> 
<221> VARIANT        
<222> (18)...(18)
<223> Xaa = Asp or absent


<220> 
<221> VARIANT        
<222> (19)...(19)
<223> Xaa = Tyr, Val or absent



<400> 159
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10                  15      
Xaa Xaa Xaa
            


<210> 160
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> (1)...(1)
<223> Xaa = Gln, Leu or Met

<220> 
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Gln

<220> 
<221> VARIANT        
<222> (3)...(3)
<223> Xaa = Leu, Tyr, Asp or Gly

<220> 
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = Asn, Asp, Tyr or Ser


<220> 
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = Ser, Arg, Asn or His


<220> 
<221> VARIANT        
<222> (6)...(6)
<223> Xaa = Tyr, Ser or Trp


<220> 
<221> VARIANT        
<222> (7)...(7)
<223> Xaa = Pro or Ser


<220> 
<221> VARIANT        
<222> (8)...(8)
<223> Xaa = Pro or absent


<220> 
<221> VARIANT        
<222> (9)...(9)
<223> Xaa = Leu, Arg, Ile, Trp or Tyr


<220> 
<221> VARIANT        
<222> (10)...(10)
<223> Xaa = Thr

<400> 160
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10  


<210> 161
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> (1)...(1)
<223> Xaa = Gly

<220> 
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Phe or Gly

<220> 
<221> VARIANT        
<222> (3)...(3)
<223> Xaa = Pro, Thr or Ser

<220> 
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = Phe


<220> 
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = Ser or Asp


<220> 
<221> VARIANT        
<222> (6)...(6)
<223> Xaa = Ser, Arg, Asp, Gly or Ala


<220> 
<221> VARIANT        
<222> (7)...(7)
<223> Xaa = Tyr or Asp


<220> 
<221> VARIANT        
<222> (8)...(8)
<223> Xaa = Asp, Gly, Ala or Tyr

<400> 161
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5              


<210> 162
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> (1)...(1)
<223> Xaa = Ile

<220> 
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Gly, Trp, Ser or Asn

<220> 
<221> VARIANT        
<222> (3)...(3)
<223> Xaa = His, Trp, Tyr or absent

<220> 
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = Thr, Asp, Asn or His


<220> 
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = Ala, Gly or Ser


<220> 
<221> VARIANT        
<222> (6)...(6)
<223> Xaa = Gly or Ser


<220> 
<221> VARIANT        
<222> (7)...(7)
<223> Xaa = Ala, Asn or Ser


<220> 
<221> VARIANT        
<222> (8)...(8)
<223> Xaa = Thr, Lys or Ile

<400> 162
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5              


<210> 163
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> (1)...(1)
<223> Xaa = Gln

<220> 
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Gly or Ser

<220> 
<221> VARIANT        
<222> (3)...(3)
<223> Xaa = Ile, Thr, Val or Leu

<220> 
<221> VARIANT        
<222> (4)...(4)
<223> Xaa = Asn, Ser, Gly or Val


<220> 
<221> VARIANT        
<222> (5)...(5)
<223> Xaa = Asn, Ser or Tyr


<220> 
<221> VARIANT        
<222> (6)...(6)
<223> Xaa = Thr or absent


<220> 
<221> VARIANT        
<222> (7)...(7)
<223> Xaa = Asp or absent


<220> 
<221> VARIANT        
<222> (8)...(8)
<223> Xaa = Gly or absent


<220> 
<221> VARIANT        
<222> (9)...(9)
<223> Xaa = Asn or absent


<220> 
<221> VARIANT        
<222> (10)...(10)
<223> Xaa = Thr or absent


<220> 
<221> VARIANT        
<222> (11)...(11)
<223> Xaa = Tyr, Trp or Asp

<400> 163
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10      


<210> 164
<211> 3
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<220> 
<221> VARIANT        
<222> (1)...(1)
<223> Xaa = Ala, Lys or Gly

<220> 
<221> VARIANT        
<222> (2)...(2)
<223> Xaa = Ala, Thr or Val

<220> 
<221> VARIANT        
<222> (3)...(3)
<223> Xaa = Ser

<400> 164
Xaa Xaa Xaa
 1          


<210> 165
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 165
Cys Gly Ala Asp Ser Tyr Glu Met Glu Glu Asp Gly Val Arg Lys Cys
 1               5                  10                  15      

