                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
 
<120>  Compositions And Methods For Regulating Pancreatic Beta Cell 
       Function Using Adipsin

<130>  DFS-134.25

<140>  PCT/US2015/019423
<141>  2015-03-09

<150>  61/952,482
<151>  2014-03-13

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  762
<212>  DNA
<213>  Homo sapiens

<400>  1
atgcacagct gggagcgcct ggcagttctg gtcctcctag gagcggccgc ctgcgcggcg       60

ccgccccgtg gtcggatcct gggcggcaga gaggccgagg cgcacgcgcg gccctacatg      120

gcgtcggtgc agctgaacgg cgcgcacctg tgcggcggcg tcctggtggc ggagcagtgg      180

gtgctgagcg cggcgcactg cctggaggac gcggccgacg ggaaggtgca ggttctcctg      240

ggcgcgcact ccctgtcgca gccggagccc tccaagcgcc tgtacgacgt gctccgcgca      300

gtgccccacc cggacagcca gcccgacacc atcgaccacg acctcctgct gctacagctg      360

tcggagaagg ccacactggg ccctgctgtg cgccccctgc cctggcagcg cgtggaccgc      420

gacgtggcac cgggaactct ctgcgacgtg gccggctggg gcatagtcaa ccacgcgggc      480

cgccgcccgg acagcctgca gcacgtgctc ttgccagtgc tggaccgcgc cacctgcaac      540

cggcgcacgc accacgacgg cgccatcacc gagcgcttga tgtgcgcgga gagcaatcgc      600

cgggacagct gcaagggtga ctccgggggc ccgctggtgt gcgggggcgt gctcgagggc      660

gtggtcacct cgggctcgcg cgtttgcggc aaccgcaaga agcccgggat ctacacccgc      720

gtggcgagct atgcggcctg gatcgacagc gtcctggcct ag                         762


<210>  2
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  2

Met His Ser Trp Glu Arg Leu Ala Val Leu Val Leu Leu Gly Ala Ala 
1               5                   10                  15      


Ala Cys Ala Ala Pro Pro Arg Gly Arg Ile Leu Gly Gly Arg Glu Ala 
            20                  25                  30          


Glu Ala His Ala Arg Pro Tyr Met Ala Ser Val Gln Leu Asn Gly Ala 
        35                  40                  45              


His Leu Cys Gly Gly Val Leu Val Ala Glu Gln Trp Val Leu Ser Ala 
    50                  55                  60                  


Ala His Cys Leu Glu Asp Ala Ala Asp Gly Lys Val Gln Val Leu Leu 
65                  70                  75                  80  


Gly Ala His Ser Leu Ser Gln Pro Glu Pro Ser Lys Arg Leu Tyr Asp 
                85                  90                  95      


Val Leu Arg Ala Val Pro His Pro Asp Ser Gln Pro Asp Thr Ile Asp 
            100                 105                 110         


His Asp Leu Leu Leu Leu Gln Leu Ser Glu Lys Ala Thr Leu Gly Pro 
        115                 120                 125             


Ala Val Arg Pro Leu Pro Trp Gln Arg Val Asp Arg Asp Val Ala Pro 
    130                 135                 140                 


Gly Thr Leu Cys Asp Val Ala Gly Trp Gly Ile Val Asn His Ala Gly 
145                 150                 155                 160 


Arg Arg Pro Asp Ser Leu Gln His Val Leu Leu Pro Val Leu Asp Arg 
                165                 170                 175     


Ala Thr Cys Asn Arg Arg Thr His His Asp Gly Ala Ile Thr Glu Arg 
            180                 185                 190         


Leu Met Cys Ala Glu Ser Asn Arg Arg Asp Ser Cys Lys Gly Asp Ser 
        195                 200                 205             


Gly Gly Pro Leu Val Cys Gly Gly Val Leu Glu Gly Val Val Thr Ser 
    210                 215                 220                 


Gly Ser Arg Val Cys Gly Asn Arg Lys Lys Pro Gly Ile Tyr Thr Arg 
225                 230                 235                 240 


Val Ala Ser Tyr Ala Ala Trp Ile Asp Ser Val Leu Ala 
                245                 250             


<210>  3
<211>  780
<212>  DNA
<213>  Mus musculus

<400>  3
atgcacagct ccgtgtactt cgtggctctg gtgatcctgg gagcggctgt atgtgcagca       60

cagccccgag gccggattct gggtggccag gaggccgcag cccatgctcg gccctacatg      120

gcttccgtgc aagtgaacgg cacacacgtg tgcggtggca ccctgctgga cgagcagtgg      180

gtgctcagtg ctgcacactg catggatgga gtgacggatg acgactctgt gcaggtgctc      240

ctgggtgccc actccctgtc cgcccctgaa ccctacaagc gatggtatga tgtgcagagt      300

gtagtgcctc acccgggcag ccgacctgac agccttgagg acgacctcat tctttttaag      360

ctatcccaga atgcctcgtt gggtccccac gtgagacccc tacccttgca atacgaggac      420

aaagaagtgg aacccggcac gctctgcgac gtggctggtt ggggtgtggt cacccatgca      480

ggacgcaggc ctgatgtcct gcatcaactc agagtgtcaa tcatgaaccg gacaacctgc      540

aatctgcgca cgtaccatga cggggtagtc accattaaca tgatgtgtgc agagagcaac      600

cgcagggaca cttgcagggg agactccggc agccctctag tgtgcgggga tgcagtcgaa      660

ggtgtggtta cgtggggctc tcgcgtctgt ggcaatggca aaaagccggg cgtctatacc      720

cgagtgtcat cctaccggat gtggatcgaa aacatcacaa atggtaacat gacatcctga      780


<210>  4
<211>  259
<212>  PRT
<213>  Mus musculus

<400>  4

Met His Ser Ser Val Tyr Phe Val Ala Leu Val Ile Leu Gly Ala Ala 
1               5                   10                  15      


Val Cys Ala Ala Gln Pro Arg Gly Arg Ile Leu Gly Gly Gln Glu Ala 
            20                  25                  30          


Ala Ala His Ala Arg Pro Tyr Met Ala Ser Val Gln Val Asn Gly Thr 
        35                  40                  45              


His Val Cys Gly Gly Thr Leu Leu Asp Glu Gln Trp Val Leu Ser Ala 
    50                  55                  60                  


Ala His Cys Met Asp Gly Val Thr Asp Asp Asp Ser Val Gln Val Leu 
65                  70                  75                  80  


Leu Gly Ala His Ser Leu Ser Ala Pro Glu Pro Tyr Lys Arg Trp Tyr 
                85                  90                  95      


Asp Val Gln Ser Val Val Pro His Pro Gly Ser Arg Pro Asp Ser Leu 
            100                 105                 110         


Glu Asp Asp Leu Ile Leu Phe Lys Leu Ser Gln Asn Ala Ser Leu Gly 
        115                 120                 125             


Pro His Val Arg Pro Leu Pro Leu Gln Tyr Glu Asp Lys Glu Val Glu 
    130                 135                 140                 


Pro Gly Thr Leu Cys Asp Val Ala Gly Trp Gly Val Val Thr His Ala 
145                 150                 155                 160 


Gly Arg Arg Pro Asp Val Leu His Gln Leu Arg Val Ser Ile Met Asn 
                165                 170                 175     


Arg Thr Thr Cys Asn Leu Arg Thr Tyr His Asp Gly Val Val Thr Ile 
            180                 185                 190         


Asn Met Met Cys Ala Glu Ser Asn Arg Arg Asp Thr Cys Arg Gly Asp 
        195                 200                 205             


Ser Gly Ser Pro Leu Val Cys Gly Asp Ala Val Glu Gly Val Val Thr 
    210                 215                 220                 


Trp Gly Ser Arg Val Cys Gly Asn Gly Lys Lys Pro Gly Val Tyr Thr 
225                 230                 235                 240 


Arg Val Ser Ser Tyr Arg Met Trp Ile Glu Asn Ile Thr Asn Gly Asn 
                245                 250                 255     


Met Thr Ser 
            


<210>  5
<211>  762
<212>  DNA
<213>  Pan troglodytes

<400>  5
atgcacagct gggagcgcct ggcagttctg gtcctcctag gagcggccgc ctgcgcggcg       60

ccgccccgtg gtcggatcct gggcggcaga gaggccgagg cgcacgcgcg gccctacatg      120

gcgtcggtgc agctgaacgg cgcgcacctg tgcggcggcg tcctggtggc ggagcagtgg      180

gtgctgagcg cggcgcactg cctggaggac gcggccggcg ggaaggtgca ggttctcctg      240

ggcgcgcact ccctgtcgca gccggagccc tccaagcgcc tgtacgacgt gctccgcgca      300

gtgccccacc cggacagcca gcctgacacc atcgaccacg acctcctgct gctacagctg      360

tcggagaagg ccacgctggg ccctgctgtg cgctccctgc cctggcagcg cgtggaccgc      420

gacgtggcgc cgggaactct ctgtgacgtg gccggctggg gcatagtcaa ccacgcgggc      480

cgccgcccgg acaggctgca gcacgtgctc ttgccagtgc tggaccgcgc cacctgcaac      540

cggcgcacgc accacgacgg cgccatcacc gagcgcatga tgtgcgcgga gagcaatcgc      600

cgggacagct gcaagggtga ctccgggggc ccgctggtgt gcgggggcgt gctcgagggt      660

gtggtcacct cgggctcgcg cgtttgcggc aaccgcaaga agcccgggat ctacacccgc      720

gtggcgagct atgcggcctg gatcgacagc gtcctggcct ag                         762


<210>  6
<211>  253
<212>  PRT
<213>  Pan troglodytes

<400>  6

Met His Ser Trp Glu Arg Leu Ala Val Leu Val Leu Leu Gly Ala Ala 
1               5                   10                  15      


Ala Cys Ala Ala Pro Pro Arg Gly Arg Ile Leu Gly Gly Arg Glu Ala 
            20                  25                  30          


Glu Ala His Ala Arg Pro Tyr Met Ala Ser Val Gln Leu Asn Gly Ala 
        35                  40                  45              


His Leu Cys Gly Gly Val Leu Val Ala Glu Gln Trp Val Leu Ser Ala 
    50                  55                  60                  


Ala His Cys Leu Glu Asp Ala Ala Gly Gly Lys Val Gln Val Leu Leu 
65                  70                  75                  80  


Gly Ala His Ser Leu Ser Gln Pro Glu Pro Ser Lys Arg Leu Tyr Asp 
                85                  90                  95      


Val Leu Arg Ala Val Pro His Pro Asp Ser Gln Pro Asp Thr Ile Asp 
            100                 105                 110         


His Asp Leu Leu Leu Leu Gln Leu Ser Glu Lys Ala Thr Leu Gly Pro 
        115                 120                 125             


Ala Val Arg Ser Leu Pro Trp Gln Arg Val Asp Arg Asp Val Ala Pro 
    130                 135                 140                 


Gly Thr Leu Cys Asp Val Ala Gly Trp Gly Ile Val Asn His Ala Gly 
145                 150                 155                 160 


Arg Arg Pro Asp Arg Leu Gln His Val Leu Leu Pro Val Leu Asp Arg 
                165                 170                 175     


Ala Thr Cys Asn Arg Arg Thr His His Asp Gly Ala Ile Thr Glu Arg 
            180                 185                 190         


Met Met Cys Ala Glu Ser Asn Arg Arg Asp Ser Cys Lys Gly Asp Ser 
        195                 200                 205             


Gly Gly Pro Leu Val Cys Gly Gly Val Leu Glu Gly Val Val Thr Ser 
    210                 215                 220                 


Gly Ser Arg Val Cys Gly Asn Arg Lys Lys Pro Gly Ile Tyr Thr Arg 
225                 230                 235                 240 


Val Ala Ser Tyr Ala Ala Trp Ile Asp Ser Val Leu Ala 
                245                 250             


<210>  7
<211>  780
<212>  DNA
<213>  Bos taurus

<400>  7
atggcagaca gatccctgca cctggtggtt ctgatcctcc tcgggacagc cctgtgtgcg       60

gcacagcccc gtggccggat cctgcgtggc caggaggctc catcccactc ccggccctac      120

atggcatccg tgcaggtgaa tggcaagcac gtgtgcggag gcttcctgat agcagagcag      180

tgggtgatga gcgcagcgca ctgcctggag gacgtggccg atgggaaggt gcaggtcctc      240

ctgggcgcgc actccctgtc gcagccggag ccctccaagc gcctgtacga cgtgctccgc      300

gtagtgcccc acccgggcag ccggacagag accatagacc acgacctact cctgctgcag      360

ctctctgaga aagccgtgct gggccctgcc gtgcagctcc tgccatggca gcgcgaagat      420

cgcgacgtgg ctgcgggcac tctctgcgac gtggcgggct ggggcgtggt cagccacacc      480

ggccggaaac ccgaccgcct gcagcaccta ctcctgccgg tgctcgaccg cgccacctgc      540

aacctgcgaa cgtatcacga cggcaccatc actgagcgaa tgatgtgcgc ggagagcaac      600

cgccgggaca cctgcaaggg cgactccgga ggcccgctgg tgtgcggcag cgtggccgag      660

ggcgtggtca cctcgggttc acggatctgc ggcaaccaca agaagcccgg tatctacacg      720

cgcttggcga gctacgtggc ctggatcgac ggcgtcatgg ctgagggcgc agccgcctga      780


<210>  8
<211>  259
<212>  PRT
<213>  Bos taurus

<400>  8

Met Ala Asp Arg Ser Leu His Leu Val Val Leu Ile Leu Leu Gly Thr 
1               5                   10                  15      


Ala Leu Cys Ala Ala Gln Pro Arg Gly Arg Ile Leu Arg Gly Gln Glu 
            20                  25                  30          


Ala Pro Ser His Ser Arg Pro Tyr Met Ala Ser Val Gln Val Asn Gly 
        35                  40                  45              


Lys His Val Cys Gly Gly Phe Leu Ile Ala Glu Gln Trp Val Met Ser 
    50                  55                  60                  


Ala Ala His Cys Leu Glu Asp Val Ala Asp Gly Lys Val Gln Val Leu 
65                  70                  75                  80  


Leu Gly Ala His Ser Leu Ser Gln Pro Glu Pro Ser Lys Arg Leu Tyr 
                85                  90                  95      


Asp Val Leu Arg Val Val Pro His Pro Gly Ser Arg Thr Glu Thr Ile 
            100                 105                 110         


Asp His Asp Leu Leu Leu Leu Gln Leu Ser Glu Lys Ala Val Leu Gly 
        115                 120                 125             


Pro Ala Val Gln Leu Leu Pro Trp Gln Arg Glu Asp Arg Asp Val Ala 
    130                 135                 140                 


Ala Gly Thr Leu Cys Asp Val Ala Gly Trp Gly Val Val Ser His Thr 
145                 150                 155                 160 


Gly Arg Lys Pro Asp Arg Leu Gln His Leu Leu Leu Pro Val Leu Asp 
                165                 170                 175     


Arg Ala Thr Cys Asn Leu Arg Thr Tyr His Asp Gly Thr Ile Thr Glu 
            180                 185                 190         


Arg Met Met Cys Ala Glu Ser Asn Arg Arg Asp Thr Cys Lys Gly Asp 
        195                 200                 205             


Ser Gly Gly Pro Leu Val Cys Gly Ser Val Ala Glu Gly Val Val Thr 
    210                 215                 220                 


Ser Gly Ser Arg Ile Cys Gly Asn His Lys Lys Pro Gly Ile Tyr Thr 
225                 230                 235                 240 


Arg Leu Ala Ser Tyr Val Ala Trp Ile Asp Gly Val Met Ala Glu Gly 
                245                 250                 255     


Ala Ala Ala 
            


<210>  9
<211>  792
<212>  DNA
<213>  Rattus norvegicus

<400>  9
atgcacagct ccgtgtacct cgtggctctg gtggtcctgg aggcggctgt atgtgttgcg       60

cagccccgag gtcggattct gggtggccag gaggccatgg cccatgctcg gccctacatg      120

gcttcagtgc aagtgaatgg cacgcacgtg tgcggtggca ccctggtgga tgagcagtgg      180

gtgctgagcg ccgcgcactg catggatgga gtgaccaagg atgaggttgt gcaggtgctc      240

ctgggtgccc actccctgtc cagtcctgaa ccctacaagc atttgtatga tgtgcaaagt      300

gtagtgcttc acccgggcag ccggcctgac agcgttgagg acgacctcat gctctttaag      360

ctctcccaca atgcctcact gggtccccat gtgagacccc tgcccttgca acgcgaggac      420

cgggaggtga aacccggcac gctctgcgat gtggccggtt ggggcgtggt cactcatgcg      480

ggacgcaggc ccgatgtcct gcagcaactg acagtgtcaa tcatggaccg gaacacctgc      540

aatctgcgca cgtaccatga tggggcaatc accaagaaca tgatgtgtgc agagagcaac      600

cgcagggaca cttgcagggg cgactccggc ggtcctctgg tgtgcgggga tgcggtcgaa      660

gctgtggtta cgtggggatc tcgagtctgt ggcaaccgga gaaagccagg tgtctttacc      720

cgcgtggcaa cctacgtgcc gtggattgaa aacgttctga gtggtaacgt gagtgttaac      780

gtgacggcct ga                                                          792


<210>  10
<211>  263
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Met His Ser Ser Val Tyr Leu Val Ala Leu Val Val Leu Glu Ala Ala 
1               5                   10                  15      


Val Cys Val Ala Gln Pro Arg Gly Arg Ile Leu Gly Gly Gln Glu Ala 
            20                  25                  30          


Met Ala His Ala Arg Pro Tyr Met Ala Ser Val Gln Val Asn Gly Thr 
        35                  40                  45              


His Val Cys Gly Gly Thr Leu Val Asp Glu Gln Trp Val Leu Ser Ala 
    50                  55                  60                  


Ala His Cys Met Asp Gly Val Thr Lys Asp Glu Val Val Gln Val Leu 
65                  70                  75                  80  


Leu Gly Ala His Ser Leu Ser Ser Pro Glu Pro Tyr Lys His Leu Tyr 
                85                  90                  95      


Asp Val Gln Ser Val Val Leu His Pro Gly Ser Arg Pro Asp Ser Val 
            100                 105                 110         


Glu Asp Asp Leu Met Leu Phe Lys Leu Ser His Asn Ala Ser Leu Gly 
        115                 120                 125             


Pro His Val Arg Pro Leu Pro Leu Gln Arg Glu Asp Arg Glu Val Lys 
    130                 135                 140                 


Pro Gly Thr Leu Cys Asp Val Ala Gly Trp Gly Val Val Thr His Ala 
145                 150                 155                 160 


Gly Arg Arg Pro Asp Val Leu Gln Gln Leu Thr Val Ser Ile Met Asp 
                165                 170                 175     


Arg Asn Thr Cys Asn Leu Arg Thr Tyr His Asp Gly Ala Ile Thr Lys 
            180                 185                 190         


Asn Met Met Cys Ala Glu Ser Asn Arg Arg Asp Thr Cys Arg Gly Asp 
        195                 200                 205             


Ser Gly Gly Pro Leu Val Cys Gly Asp Ala Val Glu Ala Val Val Thr 
    210                 215                 220                 


Trp Gly Ser Arg Val Cys Gly Asn Arg Arg Lys Pro Gly Val Phe Thr 
225                 230                 235                 240 


Arg Val Ala Thr Tyr Val Pro Trp Ile Glu Asn Val Leu Ser Gly Asn 
                245                 250                 255     


Val Ser Val Asn Val Thr Ala 
            260             


<210>  11
<211>  750
<212>  DNA
<213>  Danio rerio

<400>  11
atgaacaggc tgattttctt ctctgtgctg ttctatgcag catttcatac tggtgactgt       60

atcacgggag ggcaagaggc taaagcacac tctcgcccgt acatggcttc agttcagtgg      120

aatggaaaac atgaatgtgg tggctttctg atctccagtc agtgggtcat gagtgctgca      180

cattgctttc aggatgggag gacatctggt gttaaggttg ttttgggtgc tcactcgttg      240

tctggagccg aggacacaaa gcaaactttt gatgctgaag tatacaacca tcctgatttc      300

agcattagca actatgacaa tgacattgcc ctgattaagt tggataagcc agtcactcag      360

agcgatgcag tcaaaccagt gaaattccag cgtgatgaga cggctgaccc taaagaagct      420

gctgttgtag aaacggctgg ttggggctca ttgaacaaca tgggaggacg acctgacaaa      480

cttcatgagc tcagtatccc agtaatggag cgatggcgct gtggccgtgc tgacttctat      540

ggagagaagt ttaccagcaa catgctctgt gctgcagaca aaagaaagga cacctgtgat      600

ggggactccg gcggtcctct tttatacaga ggcattgttg tcggaataac gtctaatgga      660

gggaagaaat gtggctcctc cagaaagcct ggactctaca caatcatttc ccactacgct      720

agttggattg atactacaac tactaagtaa                                       750


<210>  12
<211>  249
<212>  PRT
<213>  Danio rerio

<400>  12

Met Asn Arg Leu Ile Phe Phe Ser Val Leu Phe Tyr Ala Ala Phe His 
1               5                   10                  15      


Thr Gly Asp Cys Ile Thr Gly Gly Gln Glu Ala Lys Ala His Ser Arg 
            20                  25                  30          


Pro Tyr Met Ala Ser Val Gln Trp Asn Gly Lys His Glu Cys Gly Gly 
        35                  40                  45              


Phe Leu Ile Ser Ser Gln Trp Val Met Ser Ala Ala His Cys Phe Gln 
    50                  55                  60                  


Asp Gly Arg Thr Ser Gly Val Lys Val Val Leu Gly Ala His Ser Leu 
65                  70                  75                  80  


Ser Gly Ala Glu Asp Thr Lys Gln Thr Phe Asp Ala Glu Val Tyr Asn 
                85                  90                  95      


His Pro Asp Phe Ser Ile Ser Asn Tyr Asp Asn Asp Ile Ala Leu Ile 
            100                 105                 110         


Lys Leu Asp Lys Pro Val Thr Gln Ser Asp Ala Val Lys Pro Val Lys 
        115                 120                 125             


Phe Gln Arg Asp Glu Thr Ala Asp Pro Lys Glu Ala Ala Val Val Glu 
    130                 135                 140                 


Thr Ala Gly Trp Gly Ser Leu Asn Asn Met Gly Gly Arg Pro Asp Lys 
145                 150                 155                 160 


Leu His Glu Leu Ser Ile Pro Val Met Glu Arg Trp Arg Cys Gly Arg 
                165                 170                 175     


Ala Asp Phe Tyr Gly Glu Lys Phe Thr Ser Asn Met Leu Cys Ala Ala 
            180                 185                 190         


Asp Lys Arg Lys Asp Thr Cys Asp Gly Asp Ser Gly Gly Pro Leu Leu 
        195                 200                 205             


Tyr Arg Gly Ile Val Val Gly Ile Thr Ser Asn Gly Gly Lys Lys Cys 
    210                 215                 220                 


Gly Ser Ser Arg Lys Pro Gly Leu Tyr Thr Ile Ile Ser His Tyr Ala 
225                 230                 235                 240 


Ser Trp Ile Asp Thr Thr Thr Thr Lys 
                245