
                                SEQUENCE LISTING

<110> National University of Singapore
      Singapore Health Services Pte Ltd
      Cook, Stuart A.

<120> METHODS OF MODULATING WARS2
  

<130> 4459.1090001

<150> 61/952,510          
<151> 2014-03-13  

<160> 55

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 329
<212> PRT
<213> Rattus

<220> 
<221> VARIANT        
<222> 270
<223> Xaa = A or R

<400> 1
Lys Glu Ser Gly Glu Arg Val Phe Ser Gly Ile Gln Pro Thr Gly Ile
 1               5                  10                  15      
Pro His Leu Gly Asn Tyr Leu Gly Ala Ile Glu Ser Trp Val Lys Leu
            20                  25                  30          
Gln Glu Glu Tyr Asp Thr Val Ile Tyr Ser Ile Val Asp Leu His Ser
        35                  40                  45              
Ile Thr Val Pro Gln Asp Pro Gly Ile Leu Gln Gln Ser Ile Leu Asp
    50                  55                  60                  
Met Thr Ala Val Leu Leu Ala Cys Gly Ile Asp Pro Glu Arg Ser Ile
65                  70                  75                  80  
Leu Phe Gln Gln Ser Gln Val Ser Glu His Thr Gln Leu Ser Trp Ile
                85                  90                  95      
Leu Thr Cys Met Val Arg Leu Pro Arg Leu Gln His Leu His Gln Trp
            100                 105                 110         
Lys Ala Lys Ala Ala Arg Gln Lys His Asp Gly Thr Val Gly Leu Leu
        115                 120                 125             
Thr Tyr Pro Val Leu Gln Ala Ala Asp Ile Leu Cys Tyr Lys Ser Thr
    130                 135                 140                 
His Val Pro Val Gly Glu Asp Gln Val Gln His Met Glu Leu Val Gln
145                 150                 155                 160 
Asp Leu Ala Arg Ser Phe Asn Gln Lys Tyr Gly Glu Leu Phe Pro Leu
                165                 170                 175     
Pro Arg Ser Ile Leu Thr Ser Met Lys Lys Val Lys Ser Leu Arg Asp
            180                 185                 190         
Pro Ser Ala Lys Met Ser Lys Ser Asp Pro Asp Lys Leu Ala Thr Val
        195                 200                 205             
Gln Ile Thr Asp Ser Pro Glu Glu Ile Val Arg Lys Phe Arg Lys Ala
    210                 215                 220                 
Val Thr Asp Phe Thr Ser Glu Val Thr Tyr Glu Pro Asp Ser Arg Pro
225                 230                 235                 240 
Gly Val Ser Asn Met Val Ala Ile His Ala Ala Val Ser Gly Leu Ser
                245                 250                 255     
Val Glu Glu Val Val Arg Asn Ser Ala Gly Val Asp Thr Xaa Tyr Lys
            260                 265                 270         
Leu Leu Val Ala Asp Ala Val Ile Glu Lys Phe Ala Pro Ile Arg Ser
        275                 280                 285             
Glu Ile Glu Lys Leu Lys Met Asp Lys Asp His Leu Arg Lys Val Leu
    290                 295                 300                 
Leu Val Gly Ser Ala Lys Ala Lys Glu Leu Ala Ser Pro Val Phe Glu
305                 310                 315                 320 
Glu Val Lys Lys Leu Val Gly Ile Leu
                325                 


<210> 2
<211> 355
<212> PRT
<213> Mus musculus

<220> 
<221> VARIANT        
<222> 60
<223> Xaa = V or N

<220> 
<221> VARIANT        
<222> 119
<223> Xaa = H or T

<220> 
<221> VARIANT        
<222> 178
<223> Xaa = E or D

<220> 
<221> VARIANT        
<222> 237
<223> Xaa = I or T

<220> 
<221> VARIANT        
<222> 296
<223> Xaa = A or R

<400> 2
Met Ala Leu Phe Ser Val Arg Lys Ala Arg Glu Cys Trp Arg Phe Ile
 1               5                  10                  15      
Arg Ala Leu His Lys Gly Pro Ala Ala Thr Leu Ala Pro Gln Lys Glu
            20                  25                  30          
Ser Gly Glu Arg Val Phe Ser Gly Ile Gln Pro Thr Gly Ile Leu His
        35                  40                  45              
Leu Gly Asn Tyr Leu Gly Ala Ile Glu Ser Trp Xaa Leu Gln Glu Glu
    50                  55                  60                  
Tyr Asp Thr Val Ile Tyr Ser Ile Val Asp Leu His Ser Ile Thr Val
65                  70                  75                  80  
Pro Gln Asp Pro Thr Val Leu Gln Gln Ser Ile Leu Asp Met Thr Ala
                85                  90                  95      
Val Leu Leu Ala Cys Gly Ile Asn Pro Glu Lys Ser Ile Leu Phe Gln
            100                 105                 110         
Gln Ser Lys Val Ser Glu Xaa Gln Leu Ser Trp Ile Leu Thr Cys Met
        115                 120                 125             
Val Arg Leu Pro Arg Leu Gln His Leu His Gln Trp Lys Ala Lys Ala
    130                 135                 140                 
Ala Lys Gln Lys His Asp Gly Thr Val Gly Leu Leu Thr Tyr Pro Val
145                 150                 155                 160 
Leu Gln Ala Ala Asp Ile Leu Cys Tyr Lys Ser Thr His Val Pro Val
                165                 170                 175     
Gly Xaa Gln Val Gln His Met Glu Leu Val Gln Asp Leu Ala Arg Ser
            180                 185                 190         
Phe Asn Gln Lys Tyr Gly Glu Phe Phe Pro Leu Pro Lys Ser Ile Leu
        195                 200                 205             
Thr Ser Met Lys Lys Val Lys Ser Leu Arg Asp Pro Ser Ser Lys Met
    210                 215                 220                 
Ser Lys Ser Asp Pro Asp Lys Leu Ala Thr Val Arg Xaa Asp Ser Pro
225                 230                 235                 240 
Glu Glu Ile Val Gln Lys Phe Arg Lys Ala Val Thr Asp Phe Thr Ser
                245                 250                 255     
Glu Val Thr Tyr Glu Pro Asp Ser Arg Ala Gly Val Ser Asn Met Val
            260                 265                 270         
Ala Ile His Ala Ala Val Ser Gly Leu Ser Val Glu Glu Val Val Arg
        275                 280                 285             
Ser Ser Ala Gly Leu Asp Thr Xaa Tyr Lys Leu Leu Val Ala Asp Ala
    290                 295                 300                 
Val Ile Glu Lys Phe Ala Pro Ile Arg Lys Glu Ile Glu Lys Leu Lys
305                 310                 315                 320 
Met Asp Lys Asp His Leu Arg Lys Val Leu Leu Val Gly Ser Ala Lys
                325                 330                 335     
Ala Lys Glu Leu Ala Ser Pro Val Phe Glu Glu Val Lys Lys Leu Val
            340                 345                 350         
Gly Ile Leu
        355 


<210> 3
<211> 355
<212> PRT
<213> Homo sapien

<220> 
<221> VARIANT        
<222> 60
<223> Xaa = V or R

<220> 
<221> VARIANT        
<222> 119
<223> Xaa = H or T

<220> 
<221> VARIANT        
<222> 178
<223> Xaa = E or D

<220> 
<221> VARIANT        
<222> 237
<223> Xaa = I or T

<220> 
<221> VARIANT        
<222> 296
<223> Xaa = A or R

<400> 3
Met Ala Leu His Ser Met Arg Lys Ala Arg Glu Arg Trp Ser Phe Ile
 1               5                  10                  15      
Arg Ala Leu His Lys Gly Ser Ala Ala Ala Pro Ala Leu Gln Lys Asp
            20                  25                  30          
Ser Lys Lys Arg Val Phe Ser Gly Ile Gln Pro Thr Gly Ile Leu His
        35                  40                  45              
Leu Gly Asn Tyr Leu Gly Ala Ile Glu Ser Trp Xaa Leu Gln Asp Glu
    50                  55                  60                  
Tyr Asp Ser Val Leu Tyr Ser Ile Val Asp Leu His Ser Ile Thr Val
65                  70                  75                  80  
Pro Gln Asp Pro Ala Val Leu Arg Gln Ser Ile Leu Asp Met Thr Ala
                85                  90                  95      
Val Leu Leu Ala Cys Gly Ile Asn Pro Glu Lys Ser Ile Leu Phe Gln
            100                 105                 110         
Gln Ser Gln Val Ser Glu Xaa Gln Leu Ser Trp Ile Leu Ser Cys Met
        115                 120                 125             
Val Arg Leu Pro Arg Leu Gln His Leu His Gln Trp Lys Ala Lys Thr
    130                 135                 140                 
Thr Lys Gln Lys His Asp Gly Thr Val Gly Leu Leu Thr Tyr Pro Val
145                 150                 155                 160 
Leu Gln Ala Ala Asp Ile Leu Leu Tyr Lys Ser Thr His Val Pro Val
                165                 170                 175     
Gly Xaa Gln Val Gln His Met Glu Leu Val Gln Asp Leu Ala Gln Gly
            180                 185                 190         
Phe Asn Lys Lys Tyr Gly Glu Phe Phe Pro Val Pro Glu Ser Ile Leu
        195                 200                 205             
Thr Ser Met Lys Lys Val Lys Ser Leu Arg Asp Pro Ser Ala Lys Met
    210                 215                 220                 
Ser Lys Ser Asp Pro Asp Lys Leu Ala Thr Val Arg Xaa Asp Ser Pro
225                 230                 235                 240 
Glu Glu Ile Val Gln Lys Phe Arg Lys Ala Val Thr Asp Phe Thr Ser
                245                 250                 255     
Glu Val Thr Tyr Asp Pro Ala Gly Arg Ala Gly Val Ser Asn Ile Val
            260                 265                 270         
Ala Val His Ala Ala Val Thr Gly Leu Ser Val Glu Glu Val Val Arg
        275                 280                 285             
Arg Ser Ala Gly Met Asn Thr Xaa Tyr Lys Leu Ala Val Ala Asp Ala
    290                 295                 300                 
Val Ile Glu Lys Phe Ala Pro Ile Lys Arg Glu Ile Glu Lys Leu Lys
305                 310                 315                 320 
Leu Asp Lys Asp His Leu Glu Lys Val Leu Gln Ile Gly Ser Ala Lys
                325                 330                 335     
Ala Lys Glu Leu Ala Tyr Thr Val Cys Gln Glu Val Lys Lys Leu Val
            340                 345                 350         
Gly Phe Leu
        355 


<210> 4
<211> 1080
<212> DNA
<213> Homo sapien

<400> 4
atggcgctgc actcaatgcg gaaagcgcgt gagcgctgga gcttcatccg ggcacttcat 60
aagggatccg cagctgctcc cgctctccag aaagacagca agaagcgagt attttccggc 120
attcaaccta caggaatcct ccacctgggc aattacctgg gagccattga gagctgggtg 180
aggttacagg atgaatatga ctctgtatta tacagcattg ttgacctcca ctccattact 240
gtcccccaag acccagctgt ccttcggcag agcatcctgg acatgactgc tgttcttctt 300
gcctgtggca taaacccgga aaaaagcatc cttttccaac aatctcaggt gtctgaacac 360
acacaattaa gttggatcct ttcctgcatg gtcagactac ctcgattaca acatttacat 420
cagtggaagg caaagactac caagcagaag cacgatggca cggtgggcct gctcacatac 480
ccagtactcc aggcagccga cattctgttg tacaagtcca cacacgttcc tgttggggag 540
gatcaagtcc agcacatgga actagttcag gatctagcac aaggtttcaa caagaagtat 600
ggggagttct ttccagtgcc cgagtccatt ctcacatcca tgaagaaggt aaaatcccta 660
cgtgatcctt ctgccaaaat gtcgaaatca gaccctgaca aactggccac cgtccgaata 720
acagacagcc cagaggagat agtgcagaaa ttccgcaagg ctgtgacaga cttcacctcg 780
gaggtcacct atgacccggc tggccgcgct ggcgtgtcca acatagtggc ggtgcatgcc 840
gcggtgacgg ggctctccgt ggaggaagtg gtgcgccgca gcgcgggcat gaacactgct 900
cgctacaagc tggccgtggc agatgctgtg attgagaagt ttgccccaat taagcgtgaa 960
attgaaaaac tgaagctgga caaggaccat ttagagaagg ttttacaaat tggatcagca 1020
aaagccaaag aattagcata cactgtgtgc caggaggtga agaaattggt gggttttcta 1080


<210> 5
<211> 43
<212> PRT
<213> Rattus

<400> 5
Glu Ser Gly Glu Arg Val Phe Ser Gly Ile Gln Pro Thr Gly Ile Pro
 1               5                  10                  15      
His Leu Gly Asn Tyr Phe Gly Ala Ile Glu Ser Trp Val Lys Leu Gln
            20                  25                  30          
Glu Glu Tyr Asp Thr Val Ile Tyr Ser Ile Val
        35                  40              


<210> 6
<211> 43
<212> PRT
<213> Rattus

<400> 6
Glu Ser Gly Glu Arg Val Phe Ser Gly Ile Gln Pro Thr Gly Ile Pro
 1               5                  10                  15      
His Leu Gly Asn Tyr Phe Gly Ala Ile Glu Ser Trp Val Lys Leu Gln
            20                  25                  30          
Glu Glu Tyr Asp Thr Val Ile Tyr Ser Ile Val
        35                  40              


<210> 7
<211> 43
<212> PRT
<213> Rattus

<400> 7
Glu Ser Gly Glu Arg Val Phe Ser Gly Ile Gln Pro Thr Gly Ile Pro
 1               5                  10                  15      
His Leu Gly Asn Tyr Phe Gly Ala Ile Glu Ser Trp Val Lys Leu Gln
            20                  25                  30          
Glu Glu Tyr Asp Thr Val Ile Tyr Ser Ile Val
        35                  40              


<210> 8
<211> 43
<212> PRT
<213> Rattus

<400> 8
Glu Ser Gly Glu Arg Val Phe Ser Gly Ile Gln Pro Thr Gly Ile Pro
 1               5                  10                  15      
His Leu Gly Asn Tyr Leu Gly Ala Ile Glu Ser Trp Val Lys Leu Gln
            20                  25                  30          
Glu Glu Tyr Asp Thr Val Ile Tyr Ser Ile Val
        35                  40              


<210> 9
<211> 43
<212> PRT
<213> Mus musculus

<400> 9
Asp Ser Lys Lys Arg Ile Phe Ser Gly Ile Gln Pro Thr Gly Ile Leu
 1               5                  10                  15      
His Leu Gly Asn Tyr Leu Gly Ala Ile Glu Asn Trp Val Arg Leu Gln
            20                  25                  30          
Asp Glu Tyr Asp Ser Val Leu Tyr Ser Ile Val
        35                  40              


<210> 10
<211> 43
<212> PRT
<213> Homo sapien

<400> 10
Asp Ser Lys Lys Arg Val Phe Ser Gly Ile Gln Pro Thr Gly Ile Leu
 1               5                  10                  15      
His Leu Gly Asn Tyr Leu Gly Ala Ile Glu Ser Trp Val Arg Leu Gln
            20                  25                  30          
Asp Glu Tyr Asp Ser Val Leu Tyr Ser Ile Val
        35                  40              


<210> 11
<211> 43
<212> PRT
<213> Gallus gallus

<400> 11
Met Val Thr Asp Arg Ile Phe Ser Gly Ile Gln Pro Thr Gly Thr Pro
 1               5                  10                  15      
His Leu Gly Asn Tyr Leu Gly Ala Ile Gln Asn Trp Val Asn Leu Gln
            20                  25                  30          
Glu Lys Tyr Asn Ser Val Leu Tyr Ser Ile Met
        35                  40              


<210> 12
<211> 47
<212> PRT
<213> Drosophila melanogaster

<400> 12
Glu His Asn Thr Arg Trp Pro Arg Lys Val Phe Ser Gly Ile Gln Pro
 1               5                  10                  15      
Thr Gly Ser Leu His Leu Gly Asn Tyr Leu Gly Ala Val Arg Lys Trp
            20                  25                  30          
Val Gln Leu Gln Asn Ala Arg Asp Asp Val Thr Val Cys Ile Val
        35                  40                  45          


<210> 13
<211> 42
<212> PRT
<213> Danio rerio

<400> 13
Ser Lys Gly Leu Val Phe Ser Gly Ile Gln Pro Thr Gly Ile Pro His
 1               5                  10                  15      
Leu Gly Asn Tyr Leu Gly Ala Leu Glu Ser Trp Val Ala Leu Gln Asp
            20                  25                  30          
Asp Tyr Ser Thr Val Met Tyr Ser Ile Val
        35                  40          


<210> 14
<211> 46
<212> PRT
<213> Saccharomyces cerevisiae

<400> 14
His Ser Asn Ala Thr Val Phe Ser Met Ile Gln Pro Thr Gly Cys Phe
 1               5                  10                  15      
His Leu Gly Asn Tyr Leu Gly Ala Thr Arg Val Trp Thr Asp Leu Cys
            20                  25                  30          
Glu Leu Lys Gln Pro Gly Gln Glu Leu Ile Phe Gly Val Ala
        35                  40                  45      


<210> 15
<211> 14
<212> PRT
<213> Homo sapien

<400> 15
Lys Met Ser Lys Ser Asp Pro Asp Lys Leu Ala Thr Val Cys
 1               5                  10                  


<210> 16
<211> 16
<212> PRT
<213> Homo sapien

<400> 16
Cys Ile Leu Thr Ser Met Lys Lys Val Lys Ser Leu Arg Asp Pro Ser
 1               5                  10                  15      


<210> 17
<211> 20
<212> DNA
<213> Homo sapien

<400> 17
ttagtgacgc gcatgaatgg                                             20

<210> 18
<211> 23
<212> DNA
<213> Homo sapien

<400> 18
tgtggtttcg ctggatagta ggt                                         23

<210> 19
<211> 22
<212> DNA
<213> Homo sapien

<400> 19
agctcaactg cccagcgtga cc                                          22

<210> 20
<211> 22
<212> DNA
<213> Homo sapien

<400> 20
cagtcagcct tgaatcctcc cc                                          22

<210> 21
<211> 21
<212> DNA
<213> Homo sapien

<400> 21
cttcttgcct gtggcataaa c                                           21

<210> 22
<211> 22
<212> DNA
<213> Homo sapien

<400> 22
cttccactga tgtaaatgtt gt                                          22

<210> 23
<211> 20
<212> DNA
<213> Homo sapien

<400> 23
agctactgcc atccaatcgc                                             20

<210> 24
<211> 21
<212> DNA
<213> Homo sapien

<400> 24
gggcgaatcc aattccaaga g                                           21

<210> 25
<211> 47
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Forward Primer

<400> 25
gggaattcgc cgccgcgatc gccaaaggat gaaattgatt ctgcagt               47

<210> 26
<211> 56
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Reverse Primer

<400> 26
gctctagatt acttatcgtc gtcatccttg taatcctgaa agtcgaagga cagctt     56

<210> 27
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Forward Primer

<400> 27
gggaattcgt cgactggatc c                                           21

<210> 28
<211> 29
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Reverse Primer

<400> 28
gctcagagcc ggccgtttaa accttatcg                                   29

<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Forward Primer

<400> 29
gggaattcgt cgactggatc c                                           21

<210> 30
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Reverse Primer

<400> 30
gctctagagc cggccgttta aactctttct                                  30

<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Forward Primer

<400> 31
gccaccgtcc gaataacaga                                             20

<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Reverse Primer

<400> 32
catgcaccgc cactatgttg                                             20

<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Forward Primer

<400> 33
ggagtcaacg gatttggtcg                                             20

<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Reverse Primer

<400> 34
atcgccccac ttgattttgg                                             20

<210> 35
<211> 19
<212> DNA
<213> Homo sapien

<400> 35
gcattcaacc tacaggaat                                              19

<210> 36
<211> 19
<212> DNA
<213> Homo sapien

<400> 36
ccgacattct gttgtacaa                                              19

<210> 37
<211> 19
<212> DNA
<213> Homo sapien

<400> 37
gctggacaag gaccattta                                              19

<210> 38
<211> 51
<212> DNA
<213> Homo sapien

<220> 
<221> misc_feature   
<222> 26
<223> n = C or G

<400> 38
ttcatattct gtcgagacac ccatcnccct gtgtttcact tgtctgatta c          51

<210> 39
<211> 35
<212> DNA
<213> Rattus

<400> 39
acccacagct actgcggctc cccaggtaac ccgag                            35

<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Primer

<400> 40
gtgagtgctg gcgcttcatc                                             20

<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Primer

<400> 41
ggcctaaagc agaaggtcgg                                             20

<210> 42
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Forward Primer

<400> 42
tttccagcag tctcaggtgt c                                           21

<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Reverse Primer

<400> 43
tacagggtat gtgagcaggc                                             20

<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Forward Primer

<400> 44
aaagggtcat catctccgcc                                             20

<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Artificial Reverse Primer

<400> 45
ccttccacga tgccaaagtt                                             20

<210> 46
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Sense Strand

<400> 46
ugguuuacau gucgacuuu                                              19

<210> 47
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Antisense Strand

<400> 47
agucgacaug uaaaccauu                                              19

<210> 48
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Sense Strand

<400> 48
gcuccaauca gaagugauu                                              19

<210> 49
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Antisense Strand

<400> 49
ucacuucuga uuggagcuu                                              19

<210> 50
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Sense Strand

<400> 50
gcauucaacc uacaggaau                                              19

<210> 51
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Antisense Strand

<400> 51
auuccuguag guugaaugc                                              19

<210> 52
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Sense Strand

<400> 52
ccgacauucu guuguacaa                                              19

<210> 53
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Antisense Strand

<400> 53
uuguacaaca gaaugucgg                                              19

<210> 54
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Sense Strand

<400> 54
gcuggacaag gaccauuua                                              19

<210> 55
<211> 19
<212> RNA
<213> Artificial Sequence

<220> 
<223> siRNA Antisense Strand

<400> 55
uaaauggucc uuguccagc                                              19
