
                                SEQUENCE LISTING

<110> TAM, Stephen Jed
      LIU, Yue
      BARBOUR, Robin
      YEDNOCK, Theodore

<120> ANTI-LAMININ4 ANTIBODIES SPECIFIC FOR
  LG4-5

<130> 057450/459012

<150> US 61/952,132       
<151> 2014-03-12  

<150> US 62/023,760       
<151> 2014-07-11  

<150> US 62/068,349       
<151> 2014-10-24  

<160> 102

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1823
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu
 1               5                  10                  15      
Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe
            20                  25                  30          
Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro
        35                  40                  45              
Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala
    50                  55                  60                  
Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val
65                  70                  75                  80  
Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly
                85                  90                  95      
Tyr Cys Val His Cys Gln Arg Asn Thr Thr Gly Glu His Cys Glu Lys
            100                 105                 110         
Cys Leu Asp Gly Tyr Ile Gly Asp Ser Ile Arg Gly Ala Pro Gln Phe
        115                 120                 125             
Cys Gln Pro Cys Pro Cys Pro Leu Pro His Leu Ala Asn Phe Ala Glu
    130                 135                 140                 
Ser Cys Tyr Arg Lys Asn Gly Ala Val Arg Cys Ile Cys Asn Glu Asn
145                 150                 155                 160 
Tyr Ala Gly Pro Asn Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asn
                165                 170                 175     
Pro Leu Leu Ile Gly Ser Thr Cys Lys Lys Cys Asp Cys Ser Gly Asn
            180                 185                 190         
Ser Asp Pro Asn Leu Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln
        195                 200                 205             
Cys Arg Asn Cys Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys
    210                 215                 220                 
Ala Pro Gly Tyr Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val
225                 230                 235                 240 
Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu
                245                 250                 255     
Glu Glu Gly Phe Glu Pro Pro Thr Gly Met Asp Cys Pro Thr Ile Ser
            260                 265                 270         
Cys Asp Lys Cys Val Trp Asp Leu Thr Asp Ala Leu Arg Leu Ala Ala
        275                 280                 285             
Leu Ser Ile Glu Glu Gly Lys Ser Gly Val Leu Ser Val Ser Ser Gly
    290                 295                 300                 
Ala Ala Ala His Arg His Val Asn Glu Ile Asn Ala Thr Ile Tyr Leu
305                 310                 315                 320 
Leu Lys Thr Lys Leu Ser Glu Arg Glu Asn Gln Tyr Ala Leu Arg Lys
                325                 330                 335     
Ile Gln Ile Asn Asn Ala Glu Asn Thr Met Lys Ser Leu Leu Ser Asp
            340                 345                 350         
Val Glu Glu Leu Val Glu Lys Glu Asn Gln Ala Ser Arg Lys Gly Gln
        355                 360                 365             
Leu Val Gln Lys Glu Ser Met Asp Thr Ile Asn His Ala Ser Gln Leu
    370                 375                 380                 
Val Glu Gln Ala His Asp Met Arg Asp Lys Ile Gln Glu Ile Asn Asn
385                 390                 395                 400 
Lys Met Leu Tyr Tyr Gly Glu Glu His Glu Leu Ser Pro Lys Glu Ile
                405                 410                 415     
Ser Glu Lys Leu Val Leu Ala Gln Lys Met Leu Glu Glu Ile Arg Ser
            420                 425                 430         
Arg Gln Pro Phe Phe Thr Gln Arg Glu Leu Val Asp Glu Glu Ala Asp
        435                 440                 445             
Glu Ala Tyr Glu Leu Leu Ser Gln Ala Glu Ser Trp Gln Arg Leu His
    450                 455                 460                 
Asn Glu Thr Arg Thr Leu Phe Pro Val Val Leu Glu Gln Leu Asp Asp
465                 470                 475                 480 
Tyr Asn Ala Lys Leu Ser Asp Leu Gln Glu Ala Leu Asp Gln Ala Leu
                485                 490                 495     
Asn Tyr Val Arg Asp Ala Glu Asp Met Asn Arg Ala Thr Ala Ala Arg
            500                 505                 510         
Gln Arg Asp His Glu Lys Gln Gln Glu Arg Val Arg Glu Gln Met Glu
        515                 520                 525             
Val Val Asn Met Ser Leu Ser Thr Ser Ala Asp Ser Leu Thr Thr Pro
    530                 535                 540                 
Arg Leu Thr Leu Ser Glu Leu Asp Asp Ile Ile Lys Asn Ala Ser Gly
545                 550                 555                 560 
Ile Tyr Ala Glu Ile Asp Gly Ala Lys Ser Glu Leu Gln Val Lys Leu
                565                 570                 575     
Ser Asn Leu Ser Asn Leu Ser His Asp Leu Val Gln Glu Ala Ile Asp
            580                 585                 590         
His Ala Gln Asp Leu Gln Gln Glu Ala Asn Glu Leu Ser Arg Lys Leu
        595                 600                 605             
His Ser Ser Asp Met Asn Gly Leu Val Gln Lys Ala Leu Asp Ala Ser
    610                 615                 620                 
Asn Val Tyr Glu Asn Ile Val Asn Tyr Val Ser Glu Ala Asn Glu Thr
625                 630                 635                 640 
Ala Glu Phe Ala Leu Asn Thr Thr Asp Arg Ile Tyr Asp Ala Val Ser
                645                 650                 655     
Gly Ile Asp Thr Gln Ile Ile Tyr His Lys Asp Glu Ser Glu Asn Leu
            660                 665                 670         
Leu Asn Gln Ala Arg Glu Leu Gln Ala Lys Ala Glu Ser Ser Ser Asp
        675                 680                 685             
Glu Ala Val Ala Asp Thr Ser Arg Arg Val Gly Gly Ala Leu Ala Arg
    690                 695                 700                 
Lys Ser Ala Leu Lys Thr Arg Leu Ser Asp Ala Val Lys Gln Leu Gln
705                 710                 715                 720 
Ala Ala Glu Arg Gly Asp Ala Gln Gln Arg Leu Gly Gln Ser Arg Leu
                725                 730                 735     
Ile Thr Glu Glu Ala Asn Arg Thr Thr Met Glu Val Gln Gln Ala Thr
            740                 745                 750         
Ala Pro Met Ala Asn Asn Leu Thr Asn Trp Ser Gln Asn Leu Gln His
        755                 760                 765             
Phe Asp Ser Ser Ala Tyr Asn Thr Ala Val Asn Ser Ala Arg Asp Ala
    770                 775                 780                 
Val Arg Asn Leu Thr Glu Val Val Pro Gln Leu Leu Asp Gln Leu Arg
785                 790                 795                 800 
Thr Val Glu Gln Lys Arg Pro Ala Ser Asn Val Ser Ala Ser Ile Gln
                805                 810                 815     
Arg Ile Arg Glu Leu Ile Ala Gln Thr Arg Ser Val Ala Ser Lys Ile
            820                 825                 830         
Gln Val Ser Met Met Phe Asp Gly Gln Ser Ala Val Glu Val His Ser
        835                 840                 845             
Arg Thr Ser Met Asp Asp Leu Lys Ala Phe Thr Ser Leu Ser Leu Tyr
    850                 855                 860                 
Met Lys Pro Pro Val Lys Arg Pro Glu Leu Thr Glu Thr Ala Asp Gln
865                 870                 875                 880 
Phe Ile Leu Tyr Leu Gly Ser Lys Asn Ala Lys Lys Glu Tyr Met Gly
                885                 890                 895     
Leu Ala Ile Lys Asn Asp Asn Leu Val Tyr Val Tyr Asn Leu Gly Thr
            900                 905                 910         
Lys Asp Val Glu Ile Pro Leu Asp Ser Lys Pro Val Ser Ser Trp Pro
        915                 920                 925             
Ala Tyr Phe Ser Ile Val Lys Ile Glu Arg Val Gly Lys His Gly Lys
    930                 935                 940                 
Val Phe Leu Thr Val Pro Ser Leu Ser Ser Thr Ala Glu Glu Lys Phe
945                 950                 955                 960 
Ile Lys Lys Gly Glu Phe Ser Gly Asp Asp Ser Leu Leu Asp Leu Asp
                965                 970                 975     
Pro Glu Asp Thr Val Phe Tyr Val Gly Gly Val Pro Ser Asn Phe Lys
            980                 985                 990         
Leu Pro Thr Ser Leu Asn Leu Pro Gly Phe Val Gly Cys Leu Glu Leu
        995                 1000                1005            
Ala Thr Leu Asn Asn Asp Val Ile Ser Leu Tyr Asn Phe Lys His Ile
    1010                1015                1020                
Tyr Asn Met Asp Pro Ser Thr Ser Val Pro Cys Ala Arg Asp Lys Leu
1025                1030                1035               1040 
Ala Phe Thr Gln Ser Arg Ala Ala Ser Tyr Phe Phe Asp Gly Ser Gly
                1045                1050                1055    
Tyr Ala Val Val Arg Asp Ile Thr Arg Arg Gly Lys Phe Gly Gln Val
            1060                1065                1070        
Thr Arg Phe Asp Ile Glu Val Arg Thr Pro Ala Asp Asn Gly Leu Ile
        1075                1080                1085            
Leu Leu Met Val Asn Gly Ser Met Phe Phe Arg Leu Glu Met Arg Asn
    1090                1095                1100                
Gly Tyr Leu His Val Phe Tyr Asp Phe Gly Phe Ser Gly Gly Pro Val
1105                1110                1115               1120 
His Leu Glu Asp Thr Leu Lys Lys Ala Gln Ile Asn Asp Ala Lys Tyr
                1125                1130                1135    
His Glu Ile Ser Ile Ile Tyr His Asn Asp Lys Lys Met Ile Leu Val
            1140                1145                1150        
Val Asp Arg Arg His Val Lys Ser Met Asp Asn Glu Lys Met Lys Ile
        1155                1160                1165            
Pro Phe Thr Asp Ile Tyr Ile Gly Gly Ala Pro Pro Glu Ile Leu Gln
    1170                1175                1180                
Ser Arg Ala Leu Arg Ala His Leu Pro Leu Asp Ile Asn Phe Arg Gly
1185                1190                1195               1200 
Cys Met Lys Gly Phe Gln Phe Gln Lys Lys Asp Phe Asn Leu Leu Glu
                1205                1210                1215    
Gln Thr Glu Thr Leu Gly Val Gly Tyr Gly Cys Pro Glu Asp Ser Leu
            1220                1225                1230        
Ile Ser Arg Arg Ala Tyr Phe Asn Gly Gln Ser Phe Ile Ala Ser Ile
        1235                1240                1245            
Gln Lys Ile Ser Phe Phe Asp Gly Phe Glu Gly Gly Phe Asn Phe Arg
    1250                1255                1260                
Thr Leu Gln Pro Asn Gly Leu Leu Phe Tyr Tyr Ala Ser Gly Ser Asp
1265                1270                1275               1280 
Val Phe Ser Ile Ser Leu Asp Asn Gly Thr Val Ile Met Asp Val Lys
                1285                1290                1295    
Gly Ile Lys Val Gln Ser Val Asp Lys Gln Tyr Asn Asp Gly Leu Ser
            1300                1305                1310        
His Phe Val Ile Ser Ser Val Ser Pro Thr Arg Tyr Glu Leu Ile Val
        1315                1320                1325            
Asp Lys Ser Arg Val Gly Ser Lys Asn Pro Thr Lys Gly Lys Ile Glu
    1330                1335                1340                
Gln Thr Gln Ala Ser Glu Lys Lys Phe Tyr Phe Gly Gly Ser Pro Ile
1345                1350                1355               1360 
Ser Ala Gln Tyr Ala Asn Phe Thr Gly Cys Ile Ser Asn Ala Tyr Phe
                1365                1370                1375    
Thr Arg Val Asp Arg Asp Val Glu Val Glu Asp Phe Gln Arg Tyr Thr
            1380                1385                1390        
Glu Lys Val His Thr Ser Leu Tyr Glu Cys Pro Ile Glu Ser Ser Pro
        1395                1400                1405            
Leu Phe Leu Leu His Lys Lys Gly Lys Asn Leu Ser Lys Pro Lys Ala
    1410                1415                1420                
Ser Gln Asn Lys Lys Gly Gly Lys Ser Lys Asp Ala Pro Ser Trp Asp
1425                1430                1435               1440 
Pro Val Ala Leu Lys Leu Pro Glu Arg Asn Thr Pro Arg Asn Ser His
                1445                1450                1455    
Cys His Leu Ser Asn Ser Pro Arg Ala Ile Glu His Ala Tyr Gln Tyr
            1460                1465                1470        
Gly Gly Thr Ala Asn Ser Arg Gln Glu Phe Glu His Leu Lys Gly Asp
        1475                1480                1485            
Phe Gly Ala Lys Ser Gln Phe Ser Ile Arg Leu Arg Thr Arg Ser Ser
    1490                1495                1500                
His Gly Met Ile Phe Tyr Val Ser Asp Gln Glu Glu Asn Asp Phe Met
1505                1510                1515               1520 
Thr Leu Phe Leu Ala His Gly Arg Leu Val Tyr Met Phe Asn Val Gly
                1525                1530                1535    
His Lys Lys Leu Lys Ile Arg Ser Gln Glu Lys Tyr Asn Asp Gly Leu
            1540                1545                1550        
Trp His Asp Val Ile Phe Ile Arg Glu Arg Ser Ser Gly Arg Leu Val
        1555                1560                1565            
Ile Asp Gly Leu Arg Val Leu Glu Glu Ser Leu Pro Pro Thr Glu Ala
    1570                1575                1580                
Thr Trp Lys Ile Lys Gly Pro Ile Tyr Leu Gly Gly Val Ala Pro Gly
1585                1590                1595               1600 
Lys Ala Val Lys Asn Val Gln Ile Asn Ser Ile Tyr Ser Phe Ser Gly
                1605                1610                1615    
Cys Leu Ser Asn Leu Gln Leu Asn Gly Ala Ser Ile Thr Ser Ala Ser
            1620                1625                1630        
Gln Thr Phe Ser Val Thr Pro Cys Phe Glu Gly Pro Met Glu Thr Gly
        1635                1640                1645            
Thr Tyr Phe Ser Thr Glu Gly Gly Tyr Val Val Leu Asp Glu Ser Phe
    1650                1655                1660                
Asn Ile Gly Leu Lys Phe Glu Ile Ala Phe Glu Val Arg Pro Arg Ser
1665                1670                1675               1680 
Ser Ser Gly Thr Leu Val His Gly His Ser Val Asn Gly Glu Tyr Leu
                1685                1690                1695    
Asn Val His Met Lys Asn Gly Gln Val Ile Val Lys Val Asn Asn Gly
            1700                1705                1710        
Ile Arg Asp Phe Ser Thr Ser Val Thr Pro Lys Gln Ser Leu Cys Asp
        1715                1720                1725            
Gly Arg Trp His Arg Ile Thr Val Ile Arg Asp Ser Asn Val Val Gln
    1730                1735                1740                
Leu Asp Val Asp Ser Glu Val Asn His Val Val Gly Pro Leu Asn Pro
1745                1750                1755               1760 
Lys Pro Ile Asp His Arg Glu Pro Val Phe Val Gly Gly Val Pro Glu
                1765                1770                1775    
Ser Leu Leu Thr Pro Arg Leu Ala Pro Ser Lys Pro Phe Thr Gly Cys
            1780                1785                1790        
Ile Arg His Phe Val Ile Asp Gly His Pro Val Ser Phe Ser Lys Ala
        1795                1800                1805            
Ala Leu Val Ser Gly Ala Val Ser Ile Asn Ser Cys Pro Ala Ala
    1810                1815                1820            


<210> 2
<211> 1823
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu
 1               5                  10                  15      
Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe
            20                  25                  30          
Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro
        35                  40                  45              
Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala
    50                  55                  60                  
Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val
65                  70                  75                  80  
Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly
                85                  90                  95      
Tyr Cys Val His Cys Gln Arg Asn Thr Thr Gly Glu His Cys Glu Lys
            100                 105                 110         
Cys Leu Asp Gly Tyr Ile Gly Asp Ser Ile Arg Gly Ala Pro Gln Phe
        115                 120                 125             
Cys Gln Pro Cys Pro Cys Pro Leu Pro His Leu Ala Asn Phe Ala Glu
    130                 135                 140                 
Ser Cys Tyr Arg Lys Asn Gly Ala Val Arg Cys Ile Cys Asn Glu Asn
145                 150                 155                 160 
Tyr Ala Gly Pro Asn Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asn
                165                 170                 175     
Pro Leu Leu Ile Gly Ser Thr Cys Lys Lys Cys Asp Cys Ser Gly Asn
            180                 185                 190         
Ser Asp Pro Asn Leu Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln
        195                 200                 205             
Cys Arg Asn Cys Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys
    210                 215                 220                 
Ala Pro Gly Tyr Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val
225                 230                 235                 240 
Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu
                245                 250                 255     
Glu Glu Gly Phe Glu Pro Pro Thr Gly Met Asp Cys Pro Thr Ile Ser
            260                 265                 270         
Cys Asp Lys Cys Val Trp Asp Leu Thr Asp Asp Leu Arg Leu Ala Ala
        275                 280                 285             
Leu Ser Ile Glu Glu Gly Lys Ser Gly Val Leu Ser Val Ser Ser Gly
    290                 295                 300                 
Ala Ala Ala His Arg His Val Asn Glu Ile Asn Ala Thr Ile Tyr Leu
305                 310                 315                 320 
Leu Lys Thr Lys Leu Ser Glu Arg Glu Asn Gln Tyr Ala Leu Arg Lys
                325                 330                 335     
Ile Gln Ile Asn Asn Ala Glu Asn Thr Met Lys Ser Leu Leu Ser Asp
            340                 345                 350         
Val Glu Glu Leu Val Glu Lys Glu Asn Gln Ala Ser Arg Lys Gly Gln
        355                 360                 365             
Leu Val Gln Lys Glu Ser Met Asp Thr Ile Asn His Ala Ser Gln Leu
    370                 375                 380                 
Val Glu Gln Ala His Asp Met Arg Asp Lys Ile Gln Glu Ile Asn Asn
385                 390                 395                 400 
Lys Met Leu Tyr Tyr Gly Glu Glu His Glu Leu Ser Pro Lys Glu Ile
                405                 410                 415     
Ser Glu Lys Leu Val Leu Ala Gln Lys Met Leu Glu Glu Ile Arg Ser
            420                 425                 430         
Arg Gln Pro Phe Phe Thr Gln Arg Glu Leu Val Asp Glu Glu Ala Asp
        435                 440                 445             
Glu Ala Tyr Glu Leu Leu Ser Gln Ala Glu Ser Trp Gln Arg Leu His
    450                 455                 460                 
Asn Glu Thr Arg Thr Leu Phe Pro Val Val Leu Glu Gln Leu Asp Asp
465                 470                 475                 480 
Tyr Asn Ala Lys Leu Ser Asp Leu Gln Glu Ala Leu Asp Gln Ala Leu
                485                 490                 495     
Asn Tyr Val Arg Asp Ala Glu Asp Met Asn Arg Ala Thr Ala Ala Arg
            500                 505                 510         
Gln Arg Asp His Glu Lys Gln Gln Glu Arg Val Arg Glu Gln Met Glu
        515                 520                 525             
Val Val Asn Met Ser Leu Ser Thr Ser Ala Asp Ser Leu Thr Thr Pro
    530                 535                 540                 
Arg Leu Thr Leu Ser Glu Leu Asp Asp Ile Ile Lys Asn Ala Ser Gly
545                 550                 555                 560 
Ile Tyr Ala Glu Ile Asp Gly Ala Lys Ser Glu Leu Gln Val Lys Leu
                565                 570                 575     
Ser Asn Leu Ser Asn Leu Ser His Asp Leu Val Gln Glu Ala Ile Asp
            580                 585                 590         
His Ala Gln Asp Leu Gln Gln Glu Ala Asn Glu Leu Ser Arg Lys Leu
        595                 600                 605             
His Ser Ser Asp Met Asn Gly Leu Val Gln Lys Ala Leu Asp Ala Ser
    610                 615                 620                 
Asn Val Tyr Glu Asn Ile Val Asn Tyr Val Ser Glu Ala Asn Glu Thr
625                 630                 635                 640 
Ala Glu Phe Ala Leu Asn Thr Thr Asp Arg Ile Tyr Asp Ala Val Ser
                645                 650                 655     
Gly Ile Asp Thr Gln Ile Ile Tyr His Lys Asp Glu Ser Glu Asn Leu
            660                 665                 670         
Leu Asn Gln Ala Arg Glu Leu Gln Ala Lys Ala Glu Ser Ser Ser Asp
        675                 680                 685             
Glu Ala Val Ala Asp Thr Ser Arg Arg Val Gly Gly Ala Leu Ala Arg
    690                 695                 700                 
Lys Ser Ala Leu Lys Thr Arg Leu Ser Asp Ala Val Lys Gln Leu Gln
705                 710                 715                 720 
Ala Ala Glu Arg Gly Asp Ala Gln Gln Arg Leu Gly Gln Ser Arg Leu
                725                 730                 735     
Ile Thr Glu Glu Ala Asn Arg Thr Thr Met Glu Val Gln Gln Ala Thr
            740                 745                 750         
Ala Pro Met Ala Asn Asn Leu Thr Asn Trp Ser Gln Asn Leu Gln His
        755                 760                 765             
Phe Asp Ser Ser Ala Tyr Asn Thr Ala Val Asn Ser Ala Arg Asp Ala
    770                 775                 780                 
Val Arg Asn Leu Thr Glu Val Val Pro Gln Leu Leu Asp Gln Leu Arg
785                 790                 795                 800 
Thr Val Glu Gln Lys Arg Pro Ala Ser Asn Val Ser Ala Ser Ile Gln
                805                 810                 815     
Arg Ile Arg Glu Leu Ile Ala Gln Thr Arg Ser Val Ala Ser Lys Ile
            820                 825                 830         
Gln Val Ser Met Met Phe Asp Gly Gln Ser Ala Val Glu Val His Ser
        835                 840                 845             
Arg Thr Ser Met Asp Asp Leu Lys Ala Phe Thr Ser Leu Ser Leu Tyr
    850                 855                 860                 
Met Lys Pro Pro Val Lys Arg Pro Glu Leu Thr Glu Thr Ala Asp Gln
865                 870                 875                 880 
Phe Ile Leu Tyr Leu Gly Ser Lys Asn Ala Lys Lys Glu Tyr Met Gly
                885                 890                 895     
Leu Ala Ile Lys Asn Asp Asn Leu Val Tyr Val Tyr Asn Leu Gly Thr
            900                 905                 910         
Lys Asp Val Glu Ile Pro Leu Asp Ser Lys Pro Val Ser Ser Trp Pro
        915                 920                 925             
Ala Tyr Phe Ser Ile Val Lys Ile Glu Arg Val Gly Lys His Gly Lys
    930                 935                 940                 
Val Phe Leu Thr Val Pro Ser Leu Ser Ser Thr Ala Glu Glu Lys Phe
945                 950                 955                 960 
Ile Lys Lys Gly Glu Phe Ser Gly Asp Asp Ser Leu Leu Asp Leu Asp
                965                 970                 975     
Pro Glu Asp Thr Val Phe Tyr Val Gly Gly Val Pro Ser Asn Phe Lys
            980                 985                 990         
Leu Pro Thr Ser Leu Asn Leu Pro Gly Phe Val Gly Cys Leu Glu Leu
        995                 1000                1005            
Ala Thr Leu Asn Asn Asp Val Ile Ser Leu Tyr Asn Phe Lys His Ile
    1010                1015                1020                
Tyr Asn Met Asp Pro Ser Thr Ser Val Pro Cys Ala Arg Asp Lys Leu
1025                1030                1035               1040 
Ala Phe Thr Gln Ser Arg Ala Ala Ser Tyr Phe Phe Asp Gly Ser Gly
                1045                1050                1055    
Tyr Ala Val Val Arg Asp Ile Thr Arg Arg Gly Lys Phe Gly Gln Val
            1060                1065                1070        
Thr Arg Phe Asp Ile Glu Val Arg Thr Pro Ala Asp Asn Gly Leu Ile
        1075                1080                1085            
Leu Leu Met Val Asn Gly Ser Met Phe Phe Arg Leu Glu Met Arg Asn
    1090                1095                1100                
Gly Tyr Leu His Val Phe Tyr Asp Phe Gly Phe Ser Gly Gly Pro Val
1105                1110                1115               1120 
His Leu Glu Asp Thr Leu Lys Lys Ala Gln Ile Asn Asp Ala Lys Tyr
                1125                1130                1135    
His Glu Ile Ser Ile Ile Tyr His Asn Asp Lys Lys Met Ile Leu Val
            1140                1145                1150        
Val Asp Arg Arg His Val Lys Ser Met Asp Asn Glu Lys Met Lys Ile
        1155                1160                1165            
Pro Phe Thr Asp Ile Tyr Ile Gly Gly Ala Pro Pro Glu Ile Leu Gln
    1170                1175                1180                
Ser Arg Ala Leu Arg Ala His Leu Pro Leu Asp Ile Asn Phe Arg Gly
1185                1190                1195               1200 
Cys Met Lys Gly Phe Gln Phe Gln Lys Lys Asp Phe Asn Leu Leu Glu
                1205                1210                1215    
Gln Thr Glu Thr Leu Gly Val Gly Tyr Gly Cys Pro Glu Asp Ser Leu
            1220                1225                1230        
Ile Ser Arg Arg Ala Tyr Phe Asn Gly Gln Ser Phe Ile Ala Ser Ile
        1235                1240                1245            
Gln Lys Ile Ser Phe Phe Asp Gly Phe Glu Gly Gly Phe Asn Phe Arg
    1250                1255                1260                
Thr Leu Gln Pro Asn Gly Leu Leu Phe Tyr Tyr Ala Ser Gly Ser Asp
1265                1270                1275               1280 
Val Phe Ser Ile Ser Leu Asp Asn Gly Thr Val Ile Met Asp Val Lys
                1285                1290                1295    
Gly Ile Lys Val Gln Ser Val Asp Lys Gln Tyr Asn Asp Gly Leu Ser
            1300                1305                1310        
His Phe Val Ile Ser Ser Val Ser Pro Thr Arg Tyr Glu Leu Ile Val
        1315                1320                1325            
Asp Lys Ser Arg Val Gly Ser Lys Asn Pro Thr Lys Gly Lys Ile Glu
    1330                1335                1340                
Gln Thr Gln Ala Ser Glu Lys Lys Phe Tyr Phe Gly Gly Ser Pro Ile
1345                1350                1355               1360 
Ser Ala Gln Tyr Ala Asn Phe Thr Gly Cys Ile Ser Asn Ala Tyr Phe
                1365                1370                1375    
Thr Arg Val Asp Arg Asp Val Glu Val Glu Asp Phe Gln Arg Tyr Thr
            1380                1385                1390        
Glu Lys Val His Thr Ser Leu Tyr Glu Cys Pro Ile Glu Ser Ser Pro
        1395                1400                1405            
Leu Phe Leu Leu His Lys Lys Gly Lys Asn Leu Ser Lys Pro Lys Ala
    1410                1415                1420                
Ser Gln Asn Lys Lys Gly Gly Lys Ser Lys Asp Ala Pro Ser Trp Asp
1425                1430                1435               1440 
Pro Val Ala Leu Lys Leu Pro Glu Arg Asn Thr Pro Arg Asn Ser His
                1445                1450                1455    
Cys His Leu Ser Asn Ser Pro Arg Ala Ile Glu His Ala Tyr Gln Tyr
            1460                1465                1470        
Gly Gly Thr Ala Asn Ser Arg Gln Glu Phe Glu His Leu Lys Gly Asp
        1475                1480                1485            
Phe Gly Ala Lys Ser Gln Phe Ser Ile Arg Leu Arg Thr Arg Ser Ser
    1490                1495                1500                
His Gly Met Ile Phe Tyr Val Ser Asp Gln Glu Glu Asn Asp Phe Met
1505                1510                1515               1520 
Thr Leu Phe Leu Ala His Gly Arg Leu Val Tyr Met Phe Asn Val Gly
                1525                1530                1535    
His Lys Lys Leu Lys Ile Arg Ser Gln Glu Lys Tyr Asn Asp Gly Leu
            1540                1545                1550        
Trp His Asp Val Ile Phe Ile Arg Glu Arg Ser Ser Gly Arg Leu Val
        1555                1560                1565            
Ile Asp Gly Leu Arg Val Leu Glu Glu Ser Leu Pro Pro Thr Glu Ala
    1570                1575                1580                
Thr Trp Lys Ile Lys Gly Pro Ile Tyr Leu Gly Gly Val Ala Pro Gly
1585                1590                1595               1600 
Lys Ala Val Lys Asn Val Gln Ile Asn Ser Ile Tyr Ser Phe Ser Gly
                1605                1610                1615    
Cys Leu Ser Asn Leu Gln Leu Asn Gly Ala Ser Ile Thr Ser Ala Ser
            1620                1625                1630        
Gln Thr Phe Ser Val Thr Pro Cys Phe Glu Gly Pro Met Glu Thr Gly
        1635                1640                1645            
Thr Tyr Phe Ser Thr Glu Gly Gly Tyr Val Val Leu Asp Glu Ser Phe
    1650                1655                1660                
Asn Ile Gly Leu Lys Phe Glu Ile Ala Phe Glu Val Arg Pro Arg Ser
1665                1670                1675               1680 
Ser Ser Gly Thr Leu Val His Gly His Ser Val Asn Gly Glu Tyr Leu
                1685                1690                1695    
Asn Val His Met Lys Asn Gly Gln Val Ile Val Lys Val Asn Asn Gly
            1700                1705                1710        
Ile Arg Asp Phe Ser Thr Ser Val Thr Pro Lys Gln Ser Leu Cys Asp
        1715                1720                1725            
Gly Arg Trp His Arg Ile Thr Val Ile Arg Asp Ser Asn Val Val Gln
    1730                1735                1740                
Leu Asp Val Asp Ser Glu Val Asn His Val Val Gly Pro Leu Asn Pro
1745                1750                1755               1760 
Lys Pro Ile Asp His Arg Glu Pro Val Phe Val Gly Gly Val Pro Glu
                1765                1770                1775    
Ser Leu Leu Thr Pro Arg Leu Ala Pro Ser Lys Pro Phe Thr Gly Cys
            1780                1785                1790        
Ile Arg His Phe Val Ile Asp Gly His Pro Val Ser Phe Ser Lys Ala
        1795                1800                1805            
Ala Leu Val Ser Gly Ala Val Ser Ile Asn Ser Cys Pro Ala Ala
    1810                1815                1820            


<210> 3
<211> 1816
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Leu Ser Ser Ala Trp Arg Ser Val Leu Pro Leu Trp Leu Leu
 1               5                  10                  15      
Trp Ser Ala Ala Cys Ser Arg Ala Ala Ser Gly Asp Asp Asn Ala Phe
            20                  25                  30          
Pro Phe Asp Ile Glu Gly Ser Ser Ala Val Gly Arg Gln Asp Pro Pro
        35                  40                  45              
Glu Thr Ser Glu Pro Arg Val Ala Leu Gly Arg Leu Pro Pro Ala Ala
    50                  55                  60                  
Glu Lys Cys Asn Ala Gly Phe Phe His Thr Leu Ser Gly Glu Cys Val
65                  70                  75                  80  
Pro Cys Asp Cys Asn Gly Asn Ser Asn Glu Cys Leu Asp Gly Ser Gly
                85                  90                  95      
Tyr Cys Val His Cys Gln Arg Asn Thr Thr Gly Glu His Cys Glu Lys
            100                 105                 110         
Cys Leu Asp Gly Tyr Ile Gly Asp Ser Ile Arg Gly Ala Pro Gln Phe
        115                 120                 125             
Cys Gln Pro Cys Pro Cys Pro Leu Pro His Leu Ala Asn Phe Ala Glu
    130                 135                 140                 
Ser Cys Tyr Arg Lys Asn Gly Ala Val Arg Cys Ile Cys Asn Glu Asn
145                 150                 155                 160 
Tyr Ala Gly Pro Asn Cys Glu Arg Cys Ala Pro Gly Tyr Tyr Gly Asn
                165                 170                 175     
Pro Leu Leu Ile Gly Ser Thr Cys Lys Lys Cys Asp Cys Ser Gly Asn
            180                 185                 190         
Ser Asp Pro Asn Leu Ile Phe Glu Asp Cys Asp Glu Val Thr Gly Gln
        195                 200                 205             
Cys Arg Asn Cys Leu Arg Asn Thr Thr Gly Phe Lys Cys Glu Arg Cys
    210                 215                 220                 
Ala Pro Gly Tyr Tyr Gly Asp Ala Arg Ile Ala Lys Asn Cys Ala Val
225                 230                 235                 240 
Cys Asn Cys Gly Gly Gly Pro Cys Asp Ser Val Thr Gly Glu Cys Leu
                245                 250                 255     
Glu Glu Gly Phe Glu Pro Pro Thr Gly Cys Asp Lys Cys Val Trp Asp
            260                 265                 270         
Leu Thr Asp Asp Leu Arg Leu Ala Ala Leu Ser Ile Glu Glu Gly Lys
        275                 280                 285             
Ser Gly Val Leu Ser Val Ser Ser Gly Ala Ala Ala His Arg His Val
    290                 295                 300                 
Asn Glu Ile Asn Ala Thr Ile Tyr Leu Leu Lys Thr Lys Leu Ser Glu
305                 310                 315                 320 
Arg Glu Asn Gln Tyr Ala Leu Arg Lys Ile Gln Ile Asn Asn Ala Glu
                325                 330                 335     
Asn Thr Met Lys Ser Leu Leu Ser Asp Val Glu Glu Leu Val Glu Lys
            340                 345                 350         
Glu Asn Gln Ala Ser Arg Lys Gly Gln Leu Val Gln Lys Glu Ser Met
        355                 360                 365             
Asp Thr Ile Asn His Ala Ser Gln Leu Val Glu Gln Ala His Asp Met
    370                 375                 380                 
Arg Asp Lys Ile Gln Glu Ile Asn Asn Lys Met Leu Tyr Tyr Gly Glu
385                 390                 395                 400 
Glu His Glu Leu Ser Pro Lys Glu Ile Ser Glu Lys Leu Val Leu Ala
                405                 410                 415     
Gln Lys Met Leu Glu Glu Ile Arg Ser Arg Gln Pro Phe Phe Thr Gln
            420                 425                 430         
Arg Glu Leu Val Asp Glu Glu Ala Asp Glu Ala Tyr Glu Leu Leu Ser
        435                 440                 445             
Gln Ala Glu Ser Trp Gln Arg Leu His Asn Glu Thr Arg Thr Leu Phe
    450                 455                 460                 
Pro Val Val Leu Glu Gln Leu Asp Asp Tyr Asn Ala Lys Leu Ser Asp
465                 470                 475                 480 
Leu Gln Glu Ala Leu Asp Gln Ala Leu Asn Tyr Val Arg Asp Ala Glu
                485                 490                 495     
Asp Met Asn Arg Ala Thr Ala Ala Arg Gln Arg Asp His Glu Lys Gln
            500                 505                 510         
Gln Glu Arg Val Arg Glu Gln Met Glu Val Val Asn Met Ser Leu Ser
        515                 520                 525             
Thr Ser Ala Asp Ser Leu Thr Thr Pro Arg Leu Thr Leu Ser Glu Leu
    530                 535                 540                 
Asp Asp Ile Ile Lys Asn Ala Ser Gly Ile Tyr Ala Glu Ile Asp Gly
545                 550                 555                 560 
Ala Lys Ser Glu Leu Gln Val Lys Leu Ser Asn Leu Ser Asn Leu Ser
                565                 570                 575     
His Asp Leu Val Gln Glu Ala Ile Asp His Ala Gln Asp Leu Gln Gln
            580                 585                 590         
Glu Ala Asn Glu Leu Ser Arg Lys Leu His Ser Ser Asp Met Asn Gly
        595                 600                 605             
Leu Val Gln Lys Ala Leu Asp Ala Ser Asn Val Tyr Glu Asn Ile Val
    610                 615                 620                 
Asn Tyr Val Ser Glu Ala Asn Glu Thr Ala Glu Phe Ala Leu Asn Thr
625                 630                 635                 640 
Thr Asp Arg Ile Tyr Asp Ala Val Ser Gly Ile Asp Thr Gln Ile Ile
                645                 650                 655     
Tyr His Lys Asp Glu Ser Glu Asn Leu Leu Asn Gln Ala Arg Glu Leu
            660                 665                 670         
Gln Ala Lys Ala Glu Ser Ser Ser Asp Glu Ala Val Ala Asp Thr Ser
        675                 680                 685             
Arg Arg Val Gly Gly Ala Leu Ala Arg Lys Ser Ala Leu Lys Thr Arg
    690                 695                 700                 
Leu Ser Asp Ala Val Lys Gln Leu Gln Ala Ala Glu Arg Gly Asp Ala
705                 710                 715                 720 
Gln Gln Arg Leu Gly Gln Ser Arg Leu Ile Thr Glu Glu Ala Asn Arg
                725                 730                 735     
Thr Thr Met Glu Val Gln Gln Ala Thr Ala Pro Met Ala Asn Asn Leu
            740                 745                 750         
Thr Asn Trp Ser Gln Asn Leu Gln His Phe Asp Ser Ser Ala Tyr Asn
        755                 760                 765             
Thr Ala Val Asn Ser Ala Arg Asp Ala Val Arg Asn Leu Thr Glu Val
    770                 775                 780                 
Val Pro Gln Leu Leu Asp Gln Leu Arg Thr Val Glu Gln Lys Arg Pro
785                 790                 795                 800 
Ala Ser Asn Val Ser Ala Ser Ile Gln Arg Ile Arg Glu Leu Ile Ala
                805                 810                 815     
Gln Thr Arg Ser Val Ala Ser Lys Ile Gln Val Ser Met Met Phe Asp
            820                 825                 830         
Gly Gln Ser Ala Val Glu Val His Ser Arg Thr Ser Met Asp Asp Leu
        835                 840                 845             
Lys Ala Phe Thr Ser Leu Ser Leu Tyr Met Lys Pro Pro Val Lys Arg
    850                 855                 860                 
Pro Glu Leu Thr Glu Thr Ala Asp Gln Phe Ile Leu Tyr Leu Gly Ser
865                 870                 875                 880 
Lys Asn Ala Lys Lys Glu Tyr Met Gly Leu Ala Ile Lys Asn Asp Asn
                885                 890                 895     
Leu Val Tyr Val Tyr Asn Leu Gly Thr Lys Asp Val Glu Ile Pro Leu
            900                 905                 910         
Asp Ser Lys Pro Val Ser Ser Trp Pro Ala Tyr Phe Ser Ile Val Lys
        915                 920                 925             
Ile Glu Arg Val Gly Lys His Gly Lys Val Phe Leu Thr Val Pro Ser
    930                 935                 940                 
Leu Ser Ser Thr Ala Glu Glu Lys Phe Ile Lys Lys Gly Glu Phe Ser
945                 950                 955                 960 
Gly Asp Asp Ser Leu Leu Asp Leu Asp Pro Glu Asp Thr Val Phe Tyr
                965                 970                 975     
Val Gly Gly Val Pro Ser Asn Phe Lys Leu Pro Thr Ser Leu Asn Leu
            980                 985                 990         
Pro Gly Phe Val Gly Cys Leu Glu Leu Ala Thr Leu Asn Asn Asp Val
        995                 1000                1005            
Ile Ser Leu Tyr Asn Phe Lys His Ile Tyr Asn Met Asp Pro Ser Thr
    1010                1015                1020                
Ser Val Pro Cys Ala Arg Asp Lys Leu Ala Phe Thr Gln Ser Arg Ala
1025                1030                1035               1040 
Ala Ser Tyr Phe Phe Asp Gly Ser Gly Tyr Ala Val Val Arg Asp Ile
                1045                1050                1055    
Thr Arg Arg Gly Lys Phe Gly Gln Val Thr Arg Phe Asp Ile Glu Val
            1060                1065                1070        
Arg Thr Pro Ala Asp Asn Gly Leu Ile Leu Leu Met Val Asn Gly Ser
        1075                1080                1085            
Met Phe Phe Arg Leu Glu Met Arg Asn Gly Tyr Leu His Val Phe Tyr
    1090                1095                1100                
Asp Phe Gly Phe Ser Gly Gly Pro Val His Leu Glu Asp Thr Leu Lys
1105                1110                1115               1120 
Lys Ala Gln Ile Asn Asp Ala Lys Tyr His Glu Ile Ser Ile Ile Tyr
                1125                1130                1135    
His Asn Asp Lys Lys Met Ile Leu Val Val Asp Arg Arg His Val Lys
            1140                1145                1150        
Ser Met Asp Asn Glu Lys Met Lys Ile Pro Phe Thr Asp Ile Tyr Ile
        1155                1160                1165            
Gly Gly Ala Pro Pro Glu Ile Leu Gln Ser Arg Ala Leu Arg Ala His
    1170                1175                1180                
Leu Pro Leu Asp Ile Asn Phe Arg Gly Cys Met Lys Gly Phe Gln Phe
1185                1190                1195               1200 
Gln Lys Lys Asp Phe Asn Leu Leu Glu Gln Thr Glu Thr Leu Gly Val
                1205                1210                1215    
Gly Tyr Gly Cys Pro Glu Asp Ser Leu Ile Ser Arg Arg Ala Tyr Phe
            1220                1225                1230        
Asn Gly Gln Ser Phe Ile Ala Ser Ile Gln Lys Ile Ser Phe Phe Asp
        1235                1240                1245            
Gly Phe Glu Gly Gly Phe Asn Phe Arg Thr Leu Gln Pro Asn Gly Leu
    1250                1255                1260                
Leu Phe Tyr Tyr Ala Ser Gly Ser Asp Val Phe Ser Ile Ser Leu Asp
1265                1270                1275               1280 
Asn Gly Thr Val Ile Met Asp Val Lys Gly Ile Lys Val Gln Ser Val
                1285                1290                1295    
Asp Lys Gln Tyr Asn Asp Gly Leu Ser His Phe Val Ile Ser Ser Val
            1300                1305                1310        
Ser Pro Thr Arg Tyr Glu Leu Ile Val Asp Lys Ser Arg Val Gly Ser
        1315                1320                1325            
Lys Asn Pro Thr Lys Gly Lys Ile Glu Gln Thr Gln Ala Ser Glu Lys
    1330                1335                1340                
Lys Phe Tyr Phe Gly Gly Ser Pro Ile Ser Ala Gln Tyr Ala Asn Phe
1345                1350                1355               1360 
Thr Gly Cys Ile Ser Asn Ala Tyr Phe Thr Arg Val Asp Arg Asp Val
                1365                1370                1375    
Glu Val Glu Asp Phe Gln Arg Tyr Thr Glu Lys Val His Thr Ser Leu
            1380                1385                1390        
Tyr Glu Cys Pro Ile Glu Ser Ser Pro Leu Phe Leu Leu His Lys Lys
        1395                1400                1405            
Gly Lys Asn Leu Ser Lys Pro Lys Ala Ser Gln Asn Lys Lys Gly Gly
    1410                1415                1420                
Lys Ser Lys Asp Ala Pro Ser Trp Asp Pro Val Ala Leu Lys Leu Pro
1425                1430                1435               1440 
Glu Arg Asn Thr Pro Arg Asn Ser His Cys His Leu Ser Asn Ser Pro
                1445                1450                1455    
Arg Ala Ile Glu His Ala Tyr Gln Tyr Gly Gly Thr Ala Asn Ser Arg
            1460                1465                1470        
Gln Glu Phe Glu His Leu Lys Gly Asp Phe Gly Ala Lys Ser Gln Phe
        1475                1480                1485            
Ser Ile Arg Leu Arg Thr Arg Ser Ser His Gly Met Ile Phe Tyr Val
    1490                1495                1500                
Ser Asp Gln Glu Glu Asn Asp Phe Met Thr Leu Phe Leu Ala His Gly
1505                1510                1515               1520 
Arg Leu Val Tyr Met Phe Asn Val Gly His Lys Lys Leu Lys Ile Arg
                1525                1530                1535    
Ser Gln Glu Lys Tyr Asn Asp Gly Leu Trp His Asp Val Ile Phe Ile
            1540                1545                1550        
Arg Glu Arg Ser Ser Gly Arg Leu Val Ile Asp Gly Leu Arg Val Leu
        1555                1560                1565            
Glu Glu Ser Leu Pro Pro Thr Glu Ala Thr Trp Lys Ile Lys Gly Pro
    1570                1575                1580                
Ile Tyr Leu Gly Gly Val Ala Pro Gly Lys Ala Val Lys Asn Val Gln
1585                1590                1595               1600 
Ile Asn Ser Ile Tyr Ser Phe Ser Gly Cys Leu Ser Asn Leu Gln Leu
                1605                1610                1615    
Asn Gly Ala Ser Ile Thr Ser Ala Ser Gln Thr Phe Ser Val Thr Pro
            1620                1625                1630        
Cys Phe Glu Gly Pro Met Glu Thr Gly Thr Tyr Phe Ser Thr Glu Gly
        1635                1640                1645            
Gly Tyr Val Val Leu Asp Glu Ser Phe Asn Ile Gly Leu Lys Phe Glu
    1650                1655                1660                
Ile Ala Phe Glu Val Arg Pro Arg Ser Ser Ser Gly Thr Leu Val His
1665                1670                1675               1680 
Gly His Ser Val Asn Gly Glu Tyr Leu Asn Val His Met Lys Asn Gly
                1685                1690                1695    
Gln Val Ile Val Lys Val Asn Asn Gly Ile Arg Asp Phe Ser Thr Ser
            1700                1705                1710        
Val Thr Pro Lys Gln Ser Leu Cys Asp Gly Arg Trp His Arg Ile Thr
        1715                1720                1725            
Val Ile Arg Asp Ser Asn Val Val Gln Leu Asp Val Asp Ser Glu Val
    1730                1735                1740                
Asn His Val Val Gly Pro Leu Asn Pro Lys Pro Ile Asp His Arg Glu
1745                1750                1755               1760 
Pro Val Phe Val Gly Gly Val Pro Glu Ser Leu Leu Thr Pro Arg Leu
                1765                1770                1775    
Ala Pro Ser Lys Pro Phe Thr Gly Cys Ile Arg His Phe Val Ile Asp
            1780                1785                1790        
Gly His Pro Val Ser Phe Ser Lys Ala Ala Leu Val Ser Gly Ala Val
        1795                1800                1805            
Ser Ile Asn Ser Cys Pro Ala Ala
    1810                1815    


<210> 4
<211> 992
<212> PRT
<213> Artificial Sequence

<220> 
<223> G domain of human LAMA4

<400> 4
Ser Lys Ile Gln Val Ser Met Met Phe Asp Gly Gln Ser Ala Val Glu
 1               5                  10                  15      
Val His Ser Arg Thr Ser Met Asp Asp Leu Lys Ala Phe Thr Ser Leu
            20                  25                  30          
Ser Leu Tyr Met Lys Pro Pro Val Lys Arg Pro Glu Leu Thr Glu Thr
        35                  40                  45              
Ala Asp Gln Phe Ile Leu Tyr Leu Gly Ser Lys Asn Ala Lys Lys Glu
    50                  55                  60                  
Tyr Met Gly Leu Ala Ile Lys Asn Asp Asn Leu Val Tyr Val Tyr Asn
65                  70                  75                  80  
Leu Gly Thr Lys Asp Val Glu Ile Pro Leu Asp Ser Lys Pro Val Ser
                85                  90                  95      
Ser Trp Pro Ala Tyr Phe Ser Ile Val Lys Ile Glu Arg Val Gly Lys
            100                 105                 110         
His Gly Lys Val Phe Leu Thr Val Pro Ser Leu Ser Ser Thr Ala Glu
        115                 120                 125             
Glu Lys Phe Ile Lys Lys Gly Glu Phe Ser Gly Asp Asp Ser Leu Leu
    130                 135                 140                 
Asp Leu Asp Pro Glu Asp Thr Val Phe Tyr Val Gly Gly Val Pro Ser
145                 150                 155                 160 
Asn Phe Lys Leu Pro Thr Ser Leu Asn Leu Pro Gly Phe Val Gly Cys
                165                 170                 175     
Leu Glu Leu Ala Thr Leu Asn Asn Asp Val Ile Ser Leu Tyr Asn Phe
            180                 185                 190         
Lys His Ile Tyr Asn Met Asp Pro Ser Thr Ser Val Pro Cys Ala Arg
        195                 200                 205             
Asp Lys Leu Ala Phe Thr Gln Ser Arg Ala Ala Ser Tyr Phe Phe Asp
    210                 215                 220                 
Gly Ser Gly Tyr Ala Val Val Arg Asp Ile Thr Arg Arg Gly Lys Phe
225                 230                 235                 240 
Gly Gln Val Thr Arg Phe Asp Ile Glu Val Arg Thr Pro Ala Asp Asn
                245                 250                 255     
Gly Leu Ile Leu Leu Met Val Asn Gly Ser Met Phe Phe Arg Leu Glu
            260                 265                 270         
Met Arg Asn Gly Tyr Leu His Val Phe Tyr Asp Phe Gly Phe Ser Ser
        275                 280                 285             
Gly Arg Val His Leu Glu Asp Thr Leu Lys Lys Ala Gln Ile Asn Asp
    290                 295                 300                 
Ala Lys Tyr His Glu Ile Ser Ile Ile Tyr His Asn Asp Lys Lys Met
305                 310                 315                 320 
Ile Leu Val Val Asp Arg Arg His Val Lys Ser Met Asp Asn Glu Lys
                325                 330                 335     
Met Lys Ile Pro Phe Thr Asp Ile Tyr Ile Gly Gly Ala Pro Pro Glu
            340                 345                 350         
Ile Leu Gln Ser Arg Ala Leu Arg Ala His Leu Pro Leu Asp Ile Asn
        355                 360                 365             
Phe Arg Gly Cys Met Lys Gly Phe Gln Phe Gln Lys Lys Asp Phe Asn
    370                 375                 380                 
Leu Leu Glu Gln Thr Glu Thr Leu Gly Val Gly Tyr Gly Cys Pro Glu
385                 390                 395                 400 
Asp Ser Leu Ile Ser Arg Arg Ala Tyr Phe Asn Gly Gln Ser Phe Ile
                405                 410                 415     
Ala Ser Ile Gln Lys Ile Ser Phe Phe Asp Gly Phe Glu Gly Gly Phe
            420                 425                 430         
Asn Phe Arg Thr Leu Gln Pro Asn Gly Leu Leu Phe Tyr Tyr Ala Ser
        435                 440                 445             
Gly Ser Asp Val Phe Ser Ile Ser Leu Asp Asn Gly Thr Val Ile Met
    450                 455                 460                 
Asp Val Lys Gly Ile Lys Val Gln Ser Val Asp Lys Gln Tyr Asn Asp
465                 470                 475                 480 
Gly Leu Ser His Phe Val Ile Ser Ser Val Ser Pro Thr Arg Tyr Glu
                485                 490                 495     
Leu Ile Val Asp Lys Ser Arg Val Gly Ser Lys Asn Pro Thr Lys Gly
            500                 505                 510         
Lys Ile Glu Gln Thr Gln Ala Ser Glu Lys Lys Phe Tyr Phe Gly Gly
        515                 520                 525             
Ser Pro Ile Ser Ala Gln Tyr Ala Asn Phe Thr Gly Cys Ile Ser Asn
    530                 535                 540                 
Ala Tyr Phe Thr Arg Val Asp Arg Asp Val Glu Val Glu Asp Phe Gln
545                 550                 555                 560 
Arg Tyr Thr Glu Lys Val His Thr Ser Leu Tyr Glu Cys Pro Ile Glu
                565                 570                 575     
Ser Ser Pro Leu Phe Leu Leu His Lys Lys Gly Lys Asn Leu Ser Lys
            580                 585                 590         
Pro Lys Ala Ser Gln Asn Lys Lys Gly Gly Lys Ser Lys Asp Ala Pro
        595                 600                 605             
Ser Trp Asp Pro Val Ala Leu Lys Leu Pro Glu Arg Asn Thr Pro Arg
    610                 615                 620                 
Asn Ser His Cys His Leu Ser Asn Ser Pro Arg Ala Ile Glu His Ala
625                 630                 635                 640 
Tyr Gln Tyr Gly Gly Thr Ala Asn Ser Arg Gln Glu Phe Glu His Leu
                645                 650                 655     
Lys Gly Asp Phe Gly Ala Lys Ser Gln Phe Ser Ile Arg Leu Arg Thr
            660                 665                 670         
Arg Ser Ser His Gly Met Ile Phe Tyr Val Ser Asp Gln Glu Glu Asn
        675                 680                 685             
Asp Phe Met Thr Leu Phe Leu Ala His Gly Arg Leu Val Tyr Met Phe
    690                 695                 700                 
Asn Val Gly His Lys Lys Leu Lys Ile Arg Ser Gln Glu Lys Tyr Asn
705                 710                 715                 720 
Asp Gly Leu Trp His Asp Val Ile Phe Ile Arg Glu Arg Ser Ser Gly
                725                 730                 735     
Arg Leu Val Ile Asp Gly Leu Arg Val Leu Glu Glu Ser Leu Pro Pro
            740                 745                 750         
Thr Glu Ala Thr Trp Lys Ile Lys Gly Pro Ile Tyr Leu Gly Gly Val
        755                 760                 765             
Ala Pro Gly Lys Ala Val Lys Asn Val Gln Ile Asn Ser Ile Tyr Ser
    770                 775                 780                 
Phe Ser Gly Cys Leu Ser Asn Leu Gln Leu Asn Gly Ala Ser Ile Thr
785                 790                 795                 800 
Ser Ala Ser Gln Thr Phe Ser Val Thr Pro Cys Phe Glu Gly Pro Met
                805                 810                 815     
Glu Thr Gly Thr Tyr Phe Ser Thr Glu Gly Gly Tyr Val Val Leu Asp
            820                 825                 830         
Glu Ser Phe Asn Ile Gly Leu Lys Phe Glu Ile Ala Phe Glu Val Arg
        835                 840                 845             
Pro Arg Ser Ser Ser Gly Thr Leu Val His Gly His Ser Val Asn Gly
    850                 855                 860                 
Glu Tyr Leu Asn Val His Met Lys Asn Gly Gln Val Ile Val Lys Val
865                 870                 875                 880 
Asn Asn Gly Ile Arg Asp Phe Ser Thr Ser Val Thr Pro Lys Gln Ser
                885                 890                 895     
Leu Cys Asp Gly Arg Trp His Arg Ile Thr Val Ile Arg Asp Ser Asn
            900                 905                 910         
Val Val Gln Leu Asp Val Asp Ser Glu Val Asn His Val Val Gly Pro
        915                 920                 925             
Leu Asn Pro Lys Pro Ile Asp His Arg Glu Pro Val Phe Val Gly Gly
    930                 935                 940                 
Val Pro Glu Ser Leu Leu Thr Pro Arg Leu Ala Pro Ser Lys Pro Phe
945                 950                 955                 960 
Thr Gly Cys Ile Arg His Phe Val Ile Asp Gly His Pro Val Ser Phe
                965                 970                 975     
Ser Lys Ala Ala Leu Val Ser Gly Ala Val Ser Ile Asn Ser Cys Pro
            980                 985                 990         


<210> 5
<211> 206
<212> PRT
<213> Artificial Sequence

<220> 
<223> LG1 module of G domain of human LAMA4

<400> 5
Ser Lys Ile Gln Val Ser Met Met Phe Asp Gly Gln Ser Ala Val Glu
 1               5                  10                  15      
Val His Ser Arg Thr Ser Met Asp Asp Leu Lys Ala Phe Thr Ser Leu
            20                  25                  30          
Ser Leu Tyr Met Lys Pro Pro Val Lys Arg Pro Glu Leu Thr Glu Thr
        35                  40                  45              
Ala Asp Gln Phe Ile Leu Tyr Leu Gly Ser Lys Asn Ala Lys Lys Glu
    50                  55                  60                  
Tyr Met Gly Leu Ala Ile Lys Asn Asp Asn Leu Val Tyr Val Tyr Asn
65                  70                  75                  80  
Leu Gly Thr Lys Asp Val Glu Ile Pro Leu Asp Ser Lys Pro Val Ser
                85                  90                  95      
Ser Trp Pro Ala Tyr Phe Ser Ile Val Lys Ile Glu Arg Val Gly Lys
            100                 105                 110         
His Gly Lys Val Phe Leu Thr Val Pro Ser Leu Ser Ser Thr Ala Glu
        115                 120                 125             
Glu Lys Phe Ile Lys Lys Gly Glu Phe Ser Gly Asp Asp Ser Leu Leu
    130                 135                 140                 
Asp Leu Asp Pro Glu Asp Thr Val Phe Tyr Val Gly Gly Val Pro Ser
145                 150                 155                 160 
Asn Phe Lys Leu Pro Thr Ser Leu Asn Leu Pro Gly Phe Val Gly Cys
                165                 170                 175     
Leu Glu Leu Ala Thr Leu Asn Asn Asp Val Ile Ser Leu Tyr Asn Phe
            180                 185                 190         
Lys His Ile Tyr Asn Met Asp Pro Ser Thr Ser Val Pro Cys
        195                 200                 205     


<210> 6
<211> 180
<212> PRT
<213> Artificial Sequence

<220> 
<223> LG2 module of G domain of human LAMA4

<400> 6
Ala Ser Tyr Phe Phe Asp Gly Ser Gly Tyr Ala Val Val Arg Asp Ile
 1               5                  10                  15      
Thr Arg Arg Gly Lys Phe Gly Gln Val Thr Arg Phe Asp Ile Glu Val
            20                  25                  30          
Arg Thr Pro Ala Asp Asn Gly Leu Ile Leu Leu Met Val Asn Gly Ser
        35                  40                  45              
Met Phe Phe Arg Leu Glu Met Arg Asn Gly Tyr Leu His Val Phe Tyr
    50                  55                  60                  
Asp Phe Gly Phe Ser Ser Gly Arg Val His Leu Glu Asp Thr Leu Lys
65                  70                  75                  80  
Lys Ala Gln Ile Asn Asp Ala Lys Tyr His Glu Ile Ser Ile Ile Tyr
                85                  90                  95      
His Asn Asp Lys Lys Met Ile Leu Val Val Asp Arg Arg His Val Lys
            100                 105                 110         
Ser Met Asp Asn Glu Lys Met Lys Ile Pro Phe Thr Asp Ile Tyr Ile
        115                 120                 125             
Gly Gly Ala Pro Pro Glu Ile Leu Gln Ser Arg Ala Leu Arg Ala His
    130                 135                 140                 
Leu Pro Leu Asp Ile Asn Phe Arg Gly Cys Met Lys Gly Phe Gln Phe
145                 150                 155                 160 
Gln Lys Lys Asp Phe Asn Leu Leu Glu Gln Thr Glu Thr Leu Gly Val
                165                 170                 175     
Gly Tyr Gly Cys
            180 


<210> 7
<211> 169
<212> PRT
<213> Artificial Sequence

<220> 
<223> LG3 module of G domain of human LAMA4

<400> 7
Ser Arg Arg Ala Tyr Phe Asn Gly Gln Ser Phe Ile Ala Ser Ile Gln
 1               5                  10                  15      
Lys Ile Ser Phe Phe Asp Gly Phe Glu Gly Gly Phe Asn Phe Arg Thr
            20                  25                  30          
Leu Gln Pro Asn Gly Leu Leu Phe Tyr Tyr Ala Ser Gly Ser Asp Val
        35                  40                  45              
Phe Ser Ile Ser Leu Asp Asn Gly Thr Val Ile Met Asp Val Lys Gly
    50                  55                  60                  
Ile Lys Val Gln Ser Val Asp Lys Gln Tyr Asn Asp Gly Leu Ser His
65                  70                  75                  80  
Phe Val Ile Ser Ser Val Ser Pro Thr Arg Tyr Glu Leu Ile Val Asp
                85                  90                  95      
Lys Ser Arg Val Gly Ser Lys Asn Pro Thr Lys Gly Lys Ile Glu Gln
            100                 105                 110         
Thr Gln Ala Ser Glu Lys Lys Phe Tyr Phe Gly Gly Ser Pro Ile Ser
        115                 120                 125             
Ala Gln Tyr Ala Asn Phe Thr Gly Cys Ile Ser Asn Ala Tyr Phe Thr
    130                 135                 140                 
Arg Val Asp Arg Asp Val Glu Val Glu Asp Phe Gln Arg Tyr Thr Glu
145                 150                 155                 160 
Lys Val His Thr Ser Leu Tyr Glu Cys
                165                 


<210> 8
<211> 601
<212> PRT
<213> Artificial Sequence

<220> 
<223> LG1-3 modules of G domain of human LAMA4

<400> 8
Ser Lys Ile Gln Val Ser Met Met Phe Asp Gly Gln Ser Ala Val Glu
 1               5                  10                  15      
Val His Ser Arg Thr Ser Met Asp Asp Leu Lys Ala Phe Thr Ser Leu
            20                  25                  30          
Ser Leu Tyr Met Lys Pro Pro Val Lys Arg Pro Glu Leu Thr Glu Thr
        35                  40                  45              
Ala Asp Gln Phe Ile Leu Tyr Leu Gly Ser Lys Asn Ala Lys Lys Glu
    50                  55                  60                  
Tyr Met Gly Leu Ala Ile Lys Asn Asp Asn Leu Val Tyr Val Tyr Asn
65                  70                  75                  80  
Leu Gly Thr Lys Asp Val Glu Ile Pro Leu Asp Ser Lys Pro Val Ser
                85                  90                  95      
Ser Trp Pro Ala Tyr Phe Ser Ile Val Lys Ile Glu Arg Val Gly Lys
            100                 105                 110         
His Gly Lys Val Phe Leu Thr Val Pro Ser Leu Ser Ser Thr Ala Glu
        115                 120                 125             
Glu Lys Phe Ile Lys Lys Gly Glu Phe Ser Gly Asp Asp Ser Leu Leu
    130                 135                 140                 
Asp Leu Asp Pro Glu Asp Thr Val Phe Tyr Val Gly Gly Val Pro Ser
145                 150                 155                 160 
Asn Phe Lys Leu Pro Thr Ser Leu Asn Leu Pro Gly Phe Val Gly Cys
                165                 170                 175     
Leu Glu Leu Ala Thr Leu Asn Asn Asp Val Ile Ser Leu Tyr Asn Phe
            180                 185                 190         
Lys His Ile Tyr Asn Met Asp Pro Ser Thr Ser Val Pro Cys Ala Arg
        195                 200                 205             
Asp Lys Leu Ala Phe Thr Gln Ser Arg Ala Ala Ser Tyr Phe Phe Asp
    210                 215                 220                 
Gly Ser Gly Tyr Ala Val Val Arg Asp Ile Thr Arg Arg Gly Lys Phe
225                 230                 235                 240 
Gly Gln Val Thr Arg Phe Asp Ile Glu Val Arg Thr Pro Ala Asp Asn
                245                 250                 255     
Gly Leu Ile Leu Leu Met Val Asn Gly Ser Met Phe Phe Arg Leu Glu
            260                 265                 270         
Met Arg Asn Gly Tyr Leu His Val Phe Tyr Asp Phe Gly Phe Ser Ser
        275                 280                 285             
Gly Arg Val His Leu Glu Asp Thr Leu Lys Lys Ala Gln Ile Asn Asp
    290                 295                 300                 
Ala Lys Tyr His Glu Ile Ser Ile Ile Tyr His Asn Asp Lys Lys Met
305                 310                 315                 320 
Ile Leu Val Val Asp Arg Arg His Val Lys Ser Met Asp Asn Glu Lys
                325                 330                 335     
Met Lys Ile Pro Phe Thr Asp Ile Tyr Ile Gly Gly Ala Pro Pro Glu
            340                 345                 350         
Ile Leu Gln Ser Arg Ala Leu Arg Ala His Leu Pro Leu Asp Ile Asn
        355                 360                 365             
Phe Arg Gly Cys Met Lys Gly Phe Gln Phe Gln Lys Lys Asp Phe Asn
    370                 375                 380                 
Leu Leu Glu Gln Thr Glu Thr Leu Gly Val Gly Tyr Gly Cys Pro Glu
385                 390                 395                 400 
Asp Ser Leu Ile Ser Arg Arg Ala Tyr Phe Asn Gly Gln Ser Phe Ile
                405                 410                 415     
Ala Ser Ile Gln Lys Ile Ser Phe Phe Asp Gly Phe Glu Gly Gly Phe
            420                 425                 430         
Asn Phe Arg Thr Leu Gln Pro Asn Gly Leu Leu Phe Tyr Tyr Ala Ser
        435                 440                 445             
Gly Ser Asp Val Phe Ser Ile Ser Leu Asp Asn Gly Thr Val Ile Met
    450                 455                 460                 
Asp Val Lys Gly Ile Lys Val Gln Ser Val Asp Lys Gln Tyr Asn Asp
465                 470                 475                 480 
Gly Leu Ser His Phe Val Ile Ser Ser Val Ser Pro Thr Arg Tyr Glu
                485                 490                 495     
Leu Ile Val Asp Lys Ser Arg Val Gly Ser Lys Asn Pro Thr Lys Gly
            500                 505                 510         
Lys Ile Glu Gln Thr Gln Ala Ser Glu Lys Lys Phe Tyr Phe Gly Gly
        515                 520                 525             
Ser Pro Ile Ser Ala Gln Tyr Ala Asn Phe Thr Gly Cys Ile Ser Asn
    530                 535                 540                 
Ala Tyr Phe Thr Arg Val Asp Arg Asp Val Glu Val Glu Asp Phe Gln
545                 550                 555                 560 
Arg Tyr Thr Glu Lys Val His Thr Ser Leu Tyr Glu Cys Pro Ile Glu
                565                 570                 575     
Ser Ser Pro Leu Phe Leu Leu His Lys Lys Gly Lys Asn Leu Ser Lys
            580                 585                 590         
Pro Lys Ala Ser Gln Asn Lys Lys Gly
        595                 600     


<210> 9
<211> 171
<212> PRT
<213> Artificial Sequence

<220> 
<223> LG4 module of G domain of human LAMA4

<400> 9
Tyr Gln Tyr Gly Gly Thr Ala Asn Ser Arg Gln Glu Phe Glu His Leu
 1               5                  10                  15      
Lys Gly Asp Phe Gly Ala Lys Ser Gln Phe Ser Ile Arg Leu Arg Thr
            20                  25                  30          
Arg Ser Ser His Gly Met Ile Phe Tyr Val Ser Asp Gln Glu Glu Asn
        35                  40                  45              
Asp Phe Met Thr Leu Phe Leu Ala His Gly Arg Leu Val Tyr Met Phe
    50                  55                  60                  
Asn Val Gly His Lys Lys Leu Lys Ile Arg Ser Gln Glu Lys Tyr Asn
65                  70                  75                  80  
Asp Gly Leu Trp His Asp Val Ile Phe Ile Arg Glu Arg Ser Ser Gly
                85                  90                  95      
Arg Leu Val Ile Asp Gly Leu Arg Val Leu Glu Glu Ser Leu Pro Pro
            100                 105                 110         
Thr Glu Ala Thr Trp Lys Ile Lys Gly Pro Ile Tyr Leu Gly Gly Val
        115                 120                 125             
Ala Pro Gly Lys Ala Val Lys Asn Val Gln Ile Asn Ser Ile Tyr Ser
    130                 135                 140                 
Phe Ser Gly Cys Leu Ser Asn Leu Gln Leu Asn Gly Ala Ser Ile Thr
145                 150                 155                 160 
Ser Ala Ser Gln Thr Phe Ser Val Thr Pro Cys
                165                 170     


<210> 10
<211> 174
<212> PRT
<213> Artificial Sequence

<220> 
<223> LG5 module of G domain of human LAMA4

<400> 10
Thr Gly Thr Tyr Phe Ser Thr Glu Gly Gly Tyr Val Val Leu Asp Glu
 1               5                  10                  15      
Ser Phe Asn Ile Gly Leu Lys Phe Glu Ile Ala Phe Glu Val Arg Pro
            20                  25                  30          
Arg Ser Ser Ser Gly Thr Leu Val His Gly His Ser Val Asn Gly Glu
        35                  40                  45              
Tyr Leu Asn Val His Met Lys Asn Gly Gln Val Ile Val Lys Val Asn
    50                  55                  60                  
Asn Gly Ile Arg Asp Phe Ser Thr Ser Val Thr Pro Lys Gln Ser Leu
65                  70                  75                  80  
Cys Asp Gly Arg Trp His Arg Ile Thr Val Ile Arg Asp Ser Asn Val
                85                  90                  95      
Val Gln Leu Asp Val Asp Ser Glu Val Asn His Val Val Gly Pro Leu
            100                 105                 110         
Asn Pro Lys Pro Ile Asp His Arg Glu Pro Val Phe Val Gly Gly Val
        115                 120                 125             
Pro Glu Ser Leu Leu Thr Pro Arg Leu Ala Pro Ser Lys Pro Phe Thr
    130                 135                 140                 
Gly Cys Ile Arg His Phe Val Ile Asp Gly His Pro Val Ser Phe Ser
145                 150                 155                 160 
Lys Ala Ala Leu Val Ser Gly Ala Val Ser Ile Asn Ser Cys
                165                 170                 


<210> 11
<211> 369
<212> PRT
<213> Artificial Sequence

<220> 
<223> LG4-5 modules of G domain of human LAMA4

<400> 11
Arg Asn Ser His Cys His Leu Ser Asn Ser Pro Arg Ala Ile Glu His
 1               5                  10                  15      
Ala Tyr Gln Tyr Gly Gly Thr Ala Asn Ser Arg Gln Glu Phe Glu His
            20                  25                  30          
Leu Lys Gly Asp Phe Gly Ala Lys Ser Gln Phe Ser Ile Arg Leu Arg
        35                  40                  45              
Thr Arg Ser Ser His Gly Met Ile Phe Tyr Val Ser Asp Gln Glu Glu
    50                  55                  60                  
Asn Asp Phe Met Thr Leu Phe Leu Ala His Gly Arg Leu Val Tyr Met
65                  70                  75                  80  
Phe Asn Val Gly His Lys Lys Leu Lys Ile Arg Ser Gln Glu Lys Tyr
                85                  90                  95      
Asn Asp Gly Leu Trp His Asp Val Ile Phe Ile Arg Glu Arg Ser Ser
            100                 105                 110         
Gly Arg Leu Val Ile Asp Gly Leu Arg Val Leu Glu Glu Ser Leu Pro
        115                 120                 125             
Pro Thr Glu Ala Thr Trp Lys Ile Lys Gly Pro Ile Tyr Leu Gly Gly
    130                 135                 140                 
Val Ala Pro Gly Lys Ala Val Lys Asn Val Gln Ile Asn Ser Ile Tyr
145                 150                 155                 160 
Ser Phe Ser Gly Cys Leu Ser Asn Leu Gln Leu Asn Gly Ala Ser Ile
                165                 170                 175     
Thr Ser Ala Ser Gln Thr Phe Ser Val Thr Pro Cys Phe Glu Gly Pro
            180                 185                 190         
Met Glu Thr Gly Thr Tyr Phe Ser Thr Glu Gly Gly Tyr Val Val Leu
        195                 200                 205             
Asp Glu Ser Phe Asn Ile Gly Leu Lys Phe Glu Ile Ala Phe Glu Val
    210                 215                 220                 
Arg Pro Arg Ser Ser Ser Gly Thr Leu Val His Gly His Ser Val Asn
225                 230                 235                 240 
Gly Glu Tyr Leu Asn Val His Met Lys Asn Gly Gln Val Ile Val Lys
                245                 250                 255     
Val Asn Asn Gly Ile Arg Asp Phe Ser Thr Ser Val Thr Pro Lys Gln
            260                 265                 270         
Ser Leu Cys Asp Gly Arg Trp His Arg Ile Thr Val Ile Arg Asp Ser
        275                 280                 285             
Asn Val Val Gln Leu Asp Val Asp Ser Glu Val Asn His Val Val Gly
    290                 295                 300                 
Pro Leu Asn Pro Lys Pro Ile Asp His Arg Glu Pro Val Phe Val Gly
305                 310                 315                 320 
Gly Val Pro Glu Ser Leu Leu Thr Pro Arg Leu Ala Pro Ser Lys Pro
                325                 330                 335     
Phe Thr Gly Cys Ile Arg His Phe Val Ile Asp Gly His Pro Val Ser
            340                 345                 350         
Phe Ser Lys Ala Ala Leu Val Ser Gly Ala Val Ser Ile Asn Ser Cys
        355                 360                 365             
Pro
    


<210> 12
<211> 310
<212> PRT
<213> Homo sapiens

<400> 12
Met Arg Arg Ala Ala Leu Trp Leu Trp Leu Cys Ala Leu Ala Leu Ser
 1               5                  10                  15      
Leu Gln Pro Ala Leu Pro Gln Ile Val Ala Thr Asn Leu Pro Pro Glu
            20                  25                  30          
Asp Gln Asp Gly Ser Gly Asp Asp Ser Asp Asn Phe Ser Gly Ser Gly
        35                  40                  45              
Ala Gly Ala Leu Gln Asp Ile Thr Leu Ser Gln Gln Thr Pro Ser Thr
    50                  55                  60                  
Trp Lys Asp Thr Gln Leu Leu Thr Ala Ile Pro Thr Ser Pro Glu Pro
65                  70                  75                  80  
Thr Gly Leu Glu Ala Thr Ala Ala Ser Thr Ser Thr Leu Pro Ala Gly
                85                  90                  95      
Glu Gly Pro Lys Glu Gly Glu Ala Val Val Leu Pro Glu Val Glu Pro
            100                 105                 110         
Gly Leu Thr Ala Arg Glu Gln Glu Ala Thr Pro Arg Pro Arg Glu Thr
        115                 120                 125             
Thr Gln Leu Pro Thr Thr His Leu Ala Ser Thr Thr Thr Ala Thr Thr
    130                 135                 140                 
Ala Gln Glu Pro Ala Thr Ser His Pro His Arg Asp Met Gln Pro Gly
145                 150                 155                 160 
His His Glu Thr Ser Thr Pro Ala Gly Pro Ser Gln Ala Asp Leu His
                165                 170                 175     
Thr Pro His Thr Glu Asp Gly Gly Pro Ser Ala Thr Glu Arg Ala Ala
            180                 185                 190         
Glu Asp Gly Ala Ser Ser Gln Leu Pro Ala Ala Glu Gly Ser Gly Glu
        195                 200                 205             
Gln Asp Phe Thr Phe Glu Thr Ser Gly Glu Asn Thr Ala Val Val Ala
    210                 215                 220                 
Val Glu Pro Asp Arg Arg Asn Gln Ser Pro Val Asp Gln Gly Ala Thr
225                 230                 235                 240 
Gly Ala Ser Gln Gly Leu Leu Asp Arg Lys Glu Val Leu Gly Gly Val
                245                 250                 255     
Ile Ala Gly Gly Leu Val Gly Leu Ile Phe Ala Val Cys Leu Val Gly
            260                 265                 270         
Phe Met Leu Tyr Arg Met Lys Lys Lys Asp Glu Gly Ser Tyr Ser Leu
        275                 280                 285             
Glu Glu Pro Lys Gln Ala Asn Gly Gly Ala Tyr Gln Lys Pro Thr Lys
    290                 295                 300                 
Gln Glu Glu Phe Tyr Ala
305                 310 


<210> 13
<211> 201
<212> PRT
<213> Homo sapiens

<400> 13
Met Arg Arg Ala Trp Ile Leu Leu Thr Leu Gly Leu Val Ala Cys Val
 1               5                  10                  15      
Ser Ala Glu Ser Arg Ala Glu Leu Thr Ser Asp Lys Asp Met Tyr Leu
            20                  25                  30          
Asp Asn Ser Ser Ile Glu Glu Ala Ser Gly Val Tyr Pro Ile Asp Asp
        35                  40                  45              
Asp Asp Tyr Ala Ser Ala Ser Gly Ser Gly Ala Asp Glu Asp Val Glu
    50                  55                  60                  
Ser Pro Glu Leu Thr Thr Ser Arg Pro Leu Pro Lys Ile Leu Leu Thr
65                  70                  75                  80  
Ser Ala Ala Pro Lys Val Glu Thr Thr Thr Leu Asn Ile Gln Asn Lys
                85                  90                  95      
Ile Pro Ala Gln Thr Lys Ser Pro Glu Glu Thr Asp Lys Glu Lys Val
            100                 105                 110         
His Leu Ser Asp Ser Glu Arg Lys Met Asp Pro Ala Glu Glu Asp Thr
        115                 120                 125             
Asn Val Tyr Thr Glu Lys His Ser Asp Ser Leu Phe Lys Arg Thr Glu
    130                 135                 140                 
Val Leu Ala Ala Val Ile Ala Gly Gly Val Ile Gly Phe Leu Phe Ala
145                 150                 155                 160 
Ile Phe Leu Ile Leu Leu Leu Val Tyr Arg Met Arg Lys Lys Asp Glu
                165                 170                 175     
Gly Ser Tyr Asp Leu Gly Glu Arg Lys Pro Ser Ser Ala Ala Tyr Gln
            180                 185                 190         
Lys Ala Pro Thr Lys Glu Phe Tyr Ala
        195                 200     


<210> 14
<211> 442
<212> PRT
<213> Homo sapiens

<400> 14
Met Lys Pro Gly Pro Pro His Arg Ala Gly Ala Ala His Gly Ala Gly
 1               5                  10                  15      
Ala Gly Ala Gly Ala Ala Ala Gly Pro Gly Ala Arg Gly Leu Leu Leu
            20                  25                  30          
Pro Pro Leu Leu Leu Leu Leu Leu Ala Gly Arg Ala Ala Gly Ala Gln
        35                  40                  45              
Arg Trp Arg Ser Glu Asn Phe Glu Arg Pro Val Asp Leu Glu Gly Ser
    50                  55                  60                  
Gly Asp Asp Asp Ser Phe Pro Asp Asp Glu Leu Asp Asp Leu Tyr Ser
65                  70                  75                  80  
Gly Ser Gly Ser Gly Tyr Phe Glu Gln Glu Ser Gly Ile Glu Thr Ala
                85                  90                  95      
Met Arg Phe Ser Pro Asp Val Ala Leu Ala Val Ser Thr Thr Pro Ala
            100                 105                 110         
Val Leu Pro Thr Thr Asn Ile Gln Pro Val Gly Thr Pro Phe Glu Glu
        115                 120                 125             
Leu Pro Ser Glu Arg Pro Thr Leu Glu Pro Ala Thr Ser Pro Leu Val
    130                 135                 140                 
Val Thr Glu Val Pro Glu Glu Pro Ser Gln Arg Ala Thr Thr Val Ser
145                 150                 155                 160 
Thr Thr Met Ala Thr Thr Ala Ala Thr Ser Thr Gly Asp Pro Thr Val
                165                 170                 175     
Ala Thr Val Pro Ala Thr Val Ala Thr Ala Thr Pro Ser Thr Pro Ala
            180                 185                 190         
Ala Pro Pro Phe Thr Ala Thr Thr Ala Val Ile Arg Thr Thr Gly Val
        195                 200                 205             
Arg Arg Leu Leu Pro Leu Pro Leu Thr Thr Val Ala Thr Ala Arg Ala
    210                 215                 220                 
Thr Thr Pro Glu Ala Pro Ser Pro Pro Thr Thr Ala Ala Val Leu Asp
225                 230                 235                 240 
Thr Glu Ala Pro Thr Pro Arg Leu Val Ser Thr Ala Thr Ser Arg Pro
                245                 250                 255     
Arg Ala Leu Pro Arg Pro Ala Thr Thr Gln Glu Pro Asp Ile Pro Glu
            260                 265                 270         
Arg Ser Thr Leu Pro Leu Gly Thr Thr Ala Pro Gly Pro Thr Glu Val
        275                 280                 285             
Ala Gln Thr Pro Thr Pro Glu Thr Phe Leu Thr Thr Ile Arg Asp Glu
    290                 295                 300                 
Pro Glu Val Pro Val Ser Gly Gly Pro Ser Gly Asp Phe Glu Leu Pro
305                 310                 315                 320 
Glu Glu Glu Thr Thr Gln Pro Asp Thr Ala Asn Glu Val Val Ala Val
                325                 330                 335     
Gly Gly Ala Ala Ala Lys Ala Ser Ser Pro Pro Gly Thr Leu Pro Lys
            340                 345                 350         
Gly Ala Arg Pro Gly Pro Gly Leu Leu Asp Asn Ala Ile Asp Ser Gly
        355                 360                 365             
Ser Ser Ala Ala Gln Leu Pro Gln Lys Ser Ile Leu Glu Arg Lys Glu
    370                 375                 380                 
Val Leu Val Ala Val Ile Val Gly Gly Val Val Gly Ala Leu Phe Ala
385                 390                 395                 400 
Ala Phe Leu Val Thr Leu Leu Ile Tyr Arg Met Lys Lys Lys Asp Glu
                405                 410                 415     
Gly Ser Tyr Thr Leu Glu Glu Pro Lys Gln Ala Ser Val Thr Tyr Gln
            420                 425                 430         
Lys Pro Asp Lys Gln Glu Glu Phe Tyr Ala
        435                 440         


<210> 15
<211> 198
<212> PRT
<213> Homo sapiens

<400> 15
Met Ala Pro Ala Arg Leu Phe Ala Leu Leu Leu Phe Phe Val Gly Gly
 1               5                  10                  15      
Val Ala Glu Ser Ile Arg Glu Thr Glu Val Ile Asp Pro Gln Asp Leu
            20                  25                  30          
Leu Glu Gly Arg Tyr Phe Ser Gly Ala Leu Pro Asp Asp Glu Asp Val
        35                  40                  45              
Val Gly Pro Gly Gln Glu Ser Asp Asp Phe Glu Leu Ser Gly Ser Gly
    50                  55                  60                  
Asp Leu Asp Asp Leu Glu Asp Ser Met Ile Gly Pro Glu Val Val His
65                  70                  75                  80  
Pro Leu Val Pro Leu Asp Asn His Ile Pro Glu Arg Ala Gly Ser Gly
                85                  90                  95      
Ser Gln Val Pro Thr Glu Pro Lys Lys Leu Glu Glu Asn Glu Val Ile
            100                 105                 110         
Pro Lys Arg Ile Ser Pro Val Glu Glu Ser Glu Asp Val Ser Asn Lys
        115                 120                 125             
Val Ser Met Ser Ser Thr Val Gln Gly Ser Asn Ile Phe Glu Arg Thr
    130                 135                 140                 
Glu Val Leu Ala Ala Leu Ile Val Gly Gly Ile Val Gly Ile Leu Phe
145                 150                 155                 160 
Ala Val Phe Leu Ile Leu Leu Leu Met Tyr Arg Met Lys Lys Lys Asp
                165                 170                 175     
Glu Gly Ser Tyr Asp Leu Gly Lys Lys Pro Ile Tyr Lys Lys Ala Pro
            180                 185                 190         
Thr Asn Glu Phe Tyr Ala
        195             


<210> 16
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> 15F7 mature heavy chain variable region

<400> 16
Gln Val Gln Leu Gln Gln Ser Gly Thr Glu Leu Ala Arg Pro Gly Ala
 1               5                  10                  15      
Ala Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Gly Leu Ser Trp Val Lys Gln Arg Ala Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Phe Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Gly Val Arg Ser Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Ser Val Thr Val Ser Ser
        115                 


<210> 17
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> 15F7 mature light chain variable region

<400> 17
Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Phe Ser Val Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ile Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys Arg
            100                 105             


<210> 18
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> 15F7 heavy chain variable region signal peptide

<400> 18
Met Glu Trp Ile Trp Ser Phe Leu Phe Ile Leu Ser Gly Thr Ala Gly
 1               5                  10                  15      
Val Gln Ser
            


<210> 19
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> 15F7 light chain variable region signal peptide

<400> 19
Met Ser Ser His Ser Arg Asn Met Lys Phe Pro Ser Gln Leu Leu Leu
 1               5                  10                  15      
Leu Leu Leu Phe Gly Ile Pro Gly Met Ile Cys
            20                  25          


<210> 20
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> 15F7 CDR-H1

<400> 20
Ser Tyr Gly Leu Ser
 1               5  


<210> 21
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> 15F7 CDR-H2

<400> 21
Glu Ile Phe Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 22
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> 15F7 CDR-H3

<400> 22
Gly Val Arg Ser Pro Gly Ala Met Asp Tyr
 1               5                  10  


<210> 23
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> 15F7 CDR-L1

<400> 23
Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Ala
 1               5                  10      


<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 15F7 CDR-L2

<400> 24
Gly Ala Thr Ser Leu Glu Thr
 1               5          


<210> 25
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 15F7 CDR-L3

<400> 25
Gln Gln Tyr Trp Ser Ile Pro Tyr Thr
 1               5                  


<210> 26
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> 6C12 mature heavy chain variable region

<400> 26
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Pro Glu Trp Ile
        35                  40                  45              
Gly Met Ile His Pro Tyr Ser Gly Ala Ile Asn Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Val Lys Gln Leu Arg Leu Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser
        115                 


<210> 27
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> 6C12 mature light chain variable region, v1

<400> 27
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Arg Gln Ser Leu Leu Asn Ser
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Val Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
            100                 105                 110         
Lys Arg
        


<210> 28
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> 6C12 heavy chain variable region signal peptide

<400> 28
Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15      
Val His Ser
            


<210> 29
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> 6C12 light chain variable region signal peptide

<400> 29
Met Glu Ser Gln Thr Gln Val Leu Met Ser Leu Leu Phe Trp Val Ser
 1               5                  10                  15      
Gly Thr Cys Gly
            20  


<210> 30
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> 6C12 CDR-H1

<400> 30
Thr Tyr Trp Met His
 1               5  


<210> 31
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> 6C12 CDR-H2

<400> 31
Met Ile His Pro Tyr Ser Gly Ala Ile Asn Tyr Asn Glu Lys Phe Lys
 1               5                  10                  15      
Ser
    


<210> 32
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> 6C12 CDR-H3

<400> 32
Gln Leu Arg Leu Leu Tyr Tyr Phe Asp Tyr
 1               5                  10  


<210> 33
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> 6C12 CDR-L1, v1

<400> 33
Lys Ser Arg Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu
 1               5                  10                  15      
Thr
    


<210> 34
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 6C12 CDR-L2

<400> 34
Trp Ala Ser Thr Arg Glu Ser
 1               5          


<210> 35
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 6C12 CDR-L3

<400> 35
Gln Asn Asp Tyr Ser Tyr Pro Leu Thr
 1               5                  


<210> 36
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> 13G10 mature heavy chain variable region, v1

<400> 36
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
            20                  25                  30          
Gly Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Ala Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Glu Arg Asp Tyr Gly Ser Ser Tyr Ala Leu Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Ser Val Thr Val Ser Ser
        115                 120     


<210> 37
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> 13G10 mature heavy chain variable region, v2

<400> 37
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Met Ile His Pro His Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Ser Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gln Leu Arg Leu Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser
        115                 


<210> 38
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> 13G10 mature light chain variable region

<400> 38
Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Phe Ser Val Ser Leu Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Thr Gly
    50                  55                  60                  
Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Pro Pro Arg
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105             


<210> 39
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> 13G10 heavy chain variable region signal peptide,
      v1

<400> 39
Met Glu Trp Ile Trp Ile Phe Leu Phe Ile Leu Ser Gly Thr Ala Gly
 1               5                  10                  15      
Val Gln Ser
            


<210> 40
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> 13G10 heavy chain variable region signal peptide,
      v2

<400> 40
Met Gly Trp Ser Tyr Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly
 1               5                  10                  15      
Val His Ser
            


<210> 41
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> 13G10 light chain variable region signal peptide

<400> 41
Met Lys Phe Pro Ser Gln Leu Leu Leu Leu Leu Leu Phe Gly Ile Pro
 1               5                  10                  15      
Gly Met Ile Cys
            20  


<210> 42
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> 13G10 CDR-H1, v1

<400> 42
Asn Tyr Gly Ile Ser
 1               5  


<210> 43
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> 13G10 CDR-H2, v1

<400> 43
Ala Ile Tyr Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 44
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> 13G10 CDR-H3, v1

<400> 44
Glu Arg Asp Tyr Gly Ser Ser Tyr Ala Leu Asp Tyr
 1               5                  10          


<210> 45
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> 13G10 CDR-H1, v2

<400> 45
Ser Tyr Trp Met His
 1               5  


<210> 46
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> 13G10 CDR-H2, v2

<400> 46
Met Ile His Pro His Ser Gly Ser Thr Asn Tyr Asn Glu Lys Phe Lys
 1               5                  10                  15      
Ser
    


<210> 47
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> 13G10 CDR-H3, v2

<400> 47
Gln Leu Arg Leu Leu Tyr Tyr Phe Asp Tyr
 1               5                  10  


<210> 48
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> 13G10 CDR-L1

<400> 48
Lys Ala Ser Glu Asp Ile Tyr Asn Arg Leu Ala
 1               5                  10      


<210> 49
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> 13G10 CDR-L2

<400> 49
Gly Ala Thr Ser Leu Glu Thr
 1               5          


<210> 50
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> 13G10 CDR-L3

<400> 50
Gln Gln Tyr Trp Ser Pro Pro Arg Thr
 1               5                  


<210> 51
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human VH acceptor FR, v1

<400> 51
Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile Ile Pro Ile Val Gly Ile Gly Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ala Val Asp Phe Asp Ser Ser Ser Ser Tyr Ser Phe Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 52
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human VH acceptor FR, v2

<400> 52
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Thr His Ser Trp Phe Ala Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Met Val Thr Val Ser Ser
        115                 


<210> 53
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human VL acceptor FR, v1

<400> 53
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105             


<210> 54
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human VL acceptor FR, v2

<400> 54
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Gly Ile Ser Asn Ser
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu
        35                  40                  45              
Tyr Ala Ala Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Gln
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105             


<210> 55
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 55
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30          
Gly Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Glu Ile Phe Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Gly Val Arg Ser Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 56
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 56
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ile Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105             


<210> 57
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 57
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Gly Leu Ser Trp Val Lys Gln Arg Ala Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Phe Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Gly Val Arg Ser Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 58
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 58
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr
            20                  25                  30          
Gly Leu Ser Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Glu Ile Phe Pro Arg Ser Gly Asn Thr Tyr Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Lys Ala Thr Ile Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys
                85                  90                  95      
Ala Arg Gly Val Arg Ser Pro Gly Ala Met Asp Tyr Trp Gly Gln Gly
            100                 105                 110         
Thr Leu Val Thr Val Ser Ser
        115                 


<210> 59
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 59
Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile
        35                  40                  45              
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Lys Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Thr
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ile Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105             


<210> 60
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 60
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Lys Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ile Pro Tyr
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 61
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human IgG1 constant region

<400> 61
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Val Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 62
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human kappa light chain constant region
      without a N-terminal arginine

<400> 62
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
 1               5                  10                  15      
Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
            20                  25                  30          
Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
        35                  40                  45              
Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
    50                  55                  60                  
Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
65                  70                  75                  80  
His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                85                  90                  95      
Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105     


<210> 63
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> 15F7 mature heavy chain variable region

<400> 63
caggttcagc tgcagcagtc tggaactgag ctggcgaggc ctggggctgc agtgaagctg 60
tcctgcaagg cttcaggcta taccttcaca agttatggtt taagctgggt gaagcagaga 120
gctggacagg gccttgagtg gattggagag atttttccta gaagtggtaa tacttactac 180
aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcgtac 240
atggagctcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aagaggggtt 300
cgtagccccg gggctatgga ctactggggt caaggaacct cagtcaccgt ctcctca    357

<210> 64
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> 15F7 mature light chain variable region

<400> 64
gacatccaga tgacacaatc ttcatcctcc ttttctgtat ctctaggaga cagagtcacc 60
attacttgca aggcaagtga ggacatatat aatcggttag cctggtatca gcagaaacca 120
ggaaatgctc ctaggctctt aatatctggt gcaaccagtt tggaaactgg ggttccttca 180
agattcagtg gcagtggatc tggaaaggat tacactctca gcattaccag tcttcagact 240
gaagatgttg ctacttatta ctgtcaacag tattggagta ttccgtacac gttcggaggg 300
gggaccaacc tggaaataaa acgg                                        324

<210> 65
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> 15F7 heavy chain variable region signal peptide

<400> 65
atggaatgga tctggagctt tctcttcatc ctgtcaggaa ctgcaggtgt ccaatcc    57

<210> 66
<211> 81
<212> DNA
<213> Artificial Sequence

<220> 
<223> 15F7 light chain variable region signal peptide

<400> 66
atgtcaagtc acagcagaaa catgaagttt ccttctcaac ttctgctctt actgctgttt 60
ggaatcccag gcatgatatg t                                           81

<210> 67
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> 6C12 mature heavy chain variable region

<400> 67
caggtccaac tgcagcagcc tggggctgag ttggtaaagc ctggggcttc agtgaaattg 60
tcctgcaagg cttctggcta cacattcacc acctactgga tgcactgggt gaagcagagg 120
cctggacaag gccctgagtg gattggaatg attcatcctt atagtggtgc cattaactat 180
aatgagaagt tcaagagcaa ggccacactg actgtagaca aatcctccag cacagcctac 240
atgcaactca gcagcctgac atctgaggac tctgcggtct attactgtgt aaaacagctc 300
aggctcctct actactttga ctactggggc caaggcacca ctctcacggt ctcctca    357

<210> 68
<211> 342
<212> DNA
<213> Artificial Sequence

<220> 
<223> 6C12 mature light chain variable region, v1

<400> 68
gacattgtga tgacacagtc tccatcctcc ctgactgtga cagcaggaga gaaggtcact 60
atgagctgca agtccagaca gagtctatta aacagtggaa atcaaaagaa ctacttgacc 120
tggtaccaac agaaaccagg gcagcctcct aaagtgttga tctactgggc atccactagg 180
gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacagattt cactctcacc 240
atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga ttatagttat 300
ccgctcacgt tcggtgctgg gaccaagctg gagctgaaac gg                    342

<210> 69
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> 6C12 heavy chain variable region signal peptide

<400> 69
atgggatgga gctatatcat cctctttttg gtagcaacag ctacaggtgt ccactcc    57

<210> 70
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> 6C12 light chain variable region signal peptide

<400> 70
atggaatcac agactcaggt cctcatgtcc ctgctgttct gggtatctgg tacctgtggg 60


<210> 71
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<223> 13G10 mature heavy chain variable region, v1

<400> 71
caggttcagc tgcagcagtc tggagctgaa ctggcgaggc ctggggcttc agtgaagctg 60
tcctgcaagg cttctggcta caccttcaca aactatggaa taagctgggt gaagcagaga 120
actggacagg gccttgagtg gattggagcg atttatccta gaagtggtaa tacttactac 180
aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcgtac 240
atggagctcc gcagcctgac atctgaggac tctgcggtct atttctgtgc aagagaaagg 300
gactacggta gtagctacgc tctggactac tggggtcaag gaacctcagt caccgtctcc 360
tca                                                               363

<210> 72
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> 13G10 mature heavy chain variable region, v2

<400> 72
caggtccaac tgcagcagcc tggggctgag ctggtaaagc ctggggcttc agtgaagttg 60
tcctgcaagg cttctggcta cactttcacc agctactgga tgcactgggt gaagcagagg 120
cctggacaag gccttgagtg gattggaatg attcatcctc atagtggtag tactaactac 180
aatgagaagt tcaagagcaa ggccacactg actgtagaca agtcctccag cacagcctac 240
atgcaactca gcagcctgac atctgaggac tctgcggtct attactgtgc aagacagctc 300
aggctactct actactttga ctactggggc caaggcacca ctctcacagt ctcctca    357

<210> 73
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> 13G10 mature light chain variable region

<400> 73
gacatccaga tgacacaatc ttcatcctcc ttttctgtat ctctaggaga cagagtcacc 60
attacttgca aggcaagtga ggacatatat aatcggttag cctggtatca gcagaaacca 120
ggaaatgctc ctaggctctt aatatctggt gcaaccagtt tggaaactgg ggttccttca 180
agattcactg gcagtggatc tggaaaggat tacactctca gcattaccag tcttcagact 240
gaagatgttg ctacttatta ctgtcaacag tattggagtc ctcctcggac gttcggtgga 300
ggcaccaagc tggaaatcaa acgg                                        324

<210> 74
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> 13G10 heavy chain variable region signal peptide,
      v1

<400> 74
atggaatgga tctggatctt tctcttcatc ctgtcaggaa ctgcaggtgt ccaatcc    57

<210> 75
<211> 57
<212> DNA
<213> Artificial Sequence

<220> 
<223> 13G10 heavy chain variable region signal peptide,
      v2

<400> 75
atgggatgga gctatatcat cctctttttg gtagcaacag ctacaggtgt ccactcc    57

<210> 76
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> 13G10 light chain variable region signal peptide

<400> 76
atgaagtttc cttctcaact tctgctctta ctgctgtttg gaatcccagg catgatatgt 60


<210> 77
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 77
gaggttcagc tgcagcagtc tggagctgag gtgaagaagc ctgggagtag tgtgaagctg 60
tcctgcaagg cttcaggcta taccttcaca agttatggtt taagctgggt gaagcagaga 120
gctggacagg gccttgagtg gattggagag atttttccta gaagtggtaa tacttactac 180
aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcgtac 240
atggagctcc gcagcctgag atctgaggac actgcggtct atttctgtgc aagaggggtt 300
cgtagccccg gggctatgga ctactggggt caaggaaccc tagtcaccgt ctcctca    357

<210> 78
<211> 357
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 78
gaggttcagc tgcagcagtc tggagctgag gtgaagaagc ctgggagtag tgtgaagctg 60
tcctgcaagg cttcaggcta taccttcaca agttatggtt taagctgggt gaagcagaga 120
cctggacagg gccttgagtg gattggagag atttttccta gaagtggtaa tacttactac 180
aatgagaagt tcaagggcaa ggccacaatc actgcagaca aatcctccag cacagcgtac 240
atggagctcc gcagcctgag atctgaggac actgcggtct atttctgtgc aagaggggtt 300
cgtagccccg gggctatgga ctactggggt caaggaaccc tagtcaccgt ctcctca    357

<210> 79
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 79
gacatccaga tgacacaatc ttcatcctcc ctttctgcat ctgtaggaga cagagtcacc 60
attacttgca aggcaagtga ggacatatat aatcggttag cctggtatca gcagaaacca 120
ggaaatgctc ctaggctctt aatatctggt gcaaccagtt tggaaactgg ggttccttca 180
agattcagtg gcagtggatc tggaaaggat tacactctca ccattagcag tcttcagact 240
gaagattttg ctacttatta ctgtcaacag tattggagta ttccgtacac gttcggaggg 300
gggaccaaag tggaaataaa acgt                                        324

<210> 80
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 80
gacatccaga tgacacaatc tccatcctcc ctttctgcat ctgtaggaga cagagtcacc 60
attacttgca aggcaagtga ggacatatat aatcggttag cctggtatca gcagaaacca 120
ggaaatgctc ctaagctctt aatatctggt gcaaccagtt tggaaactgg ggttccttca 180
agattcagtg gcagtggatc tggaaaggat ttcactctca ccattagcag tcttcagcct 240
gaagattttg ctacttatta ctgtcaacag tattggagta ttccgtacac gttcggaggg 300
gggaccaaag tggaaataaa acgt                                        324

<210> 81
<211> 2976
<212> DNA
<213> Artificial Sequence

<220> 
<223> G domain of human LAMA4

<400> 81
agcaagatcc aagtctccat gatgtttgat ggccagtcag ctgtggaagt gcactcgaga 60
accagtatgg atgacttaaa ggccttcacg tctctgagcc tgtacatgaa accccctgtg 120
aagcggccgg aactgaccga gactgcagat cagtttatcc tgtacctcgg aagcaaaaac 180
gccaaaaaag agtatatggg tcttgcaatc aaaaatgata atctggtata cgtctataat 240
ttgggaacta aagatgtgga gattcccctg gactccaagc ccgtcagttc ctggcctgct 300
tacttcagca ttgtcaagat tgaaagggtg ggaaaacatg gaaaggtgtt tttaacagtc 360
ccgagtctaa gtagcacagc agaggaaaag ttcattaaaa agggggaatt ttcgggagat 420
gactctctgc tggacctgga ccctgaggac acagtgtttt atgttggtgg agtgccttcc 480
aacttcaagc tccctaccag cttaaacctg cctggctttg ttggctgcct ggaactggcc 540
actttgaata atgatgtgat cagcttgtac aactttaagc acatctataa tatggacccc 600
tccacatcag tgccatgtgc ccgagataag ctggccttca ctcagagtcg ggctgccagt 660
tacttcttcg atggctccgg ttatgccgtg gtgagagaca tcacaaggag agggaaattt 720
ggtcaggtga ctcgctttga catagaagtt cgaacaccag ctgacaacgg ccttattctc 780
ctgatggtca atggaagtat gtttttcaga ctggaaatgc gcaatggtta cctacatgtg 840
ttctatgatt ttggattcag cagtggccgt gtgcatcttg aagatacgtt aaagaaagct 900
caaattaatg atgcaaaata ccatgagatc tcaatcattt accacaatga taagaaaatg 960
atcttggtag ttgacagaag gcatgtcaag agcatggata atgaaaagat gaaaatacct 1020
tttacagata tatacattgg aggagctcct ccagaaatct tacaatccag ggccctcaga 1080
gcacaccttc ccctagatat caacttcaga ggatgcatga agggcttcca gttccaaaag 1140
aaggacttca atttactgga gcagacagaa accctgggag ttggttatgg atgcccagaa 1200
gactcactta tatctcgcag agcatatttc aatggacaga gcttcattgc ttcaattcag 1260
aaaatatctt tctttgatgg ctttgaagga ggttttaatt tccgaacatt acaaccaaat 1320
gggttactat tctattatgc ttcagggtca gacgtgttct ccatctcact ggataatggt 1380
actgtcatca tggatgtaaa gggaatcaaa gttcagtcag tagataagca gtacaatgat 1440
gggctgtccc acttcgtcat tagctctgtc tcacccacaa gatatgaact gatagtagat 1500
aaaagcagag ttgggagtaa gaatcctacc aaagggaaaa tagaacagac acaagcaagt 1560
gaaaagaagt tttacttcgg tggctcacca atcagtgctc agtatgctaa tttcactggc 1620
tgcataagta atgcctactt taccagggtg gatagagatg tggaggttga agatttccaa 1680
cggtatactg aaaaggtcca cacttctctt tatgagtgtc ccattgagtc ttcaccattg 1740
tttctcctcc ataaaaaagg aaaaaattta tccaagccta aagcaagtca gaataaaaag 1800
ggagggaaaa gtaaagatgc accttcatgg gatcctgttg ctctgaaact cccagagcgg 1860
aatactccaa gaaactctca ttgccacctt tccaacagcc ctagagcaat agagcacgcc 1920
tatcaatatg gaggaacagc caacagccgc caagagtttg aacacttaaa aggagatttt 1980
ggtgccaaat ctcagttttc cattcgtctg agaactcgtt cctcccatgg catgatcttc 2040
tatgtctcag atcaagaaga gaatgacttc atgactctat ttttggccca tggccgcttg 2100
gtttacatgt ttaatgttgg tcacaaaaaa ctgaagatta gaagccagga gaaatacaat 2160
gatggcctgt ggcatgatgt gatatttatt cgagaaagga gcagtggccg actggtaatt 2220
gatggtctcc gagtcctaga agaaagtctt cctcctactg aagctacctg gaaaatcaag 2280
ggtcccattt atttgggagg tgtggctcct ggaaaggctg tgaaaaatgt tcagattaac 2340
tccatctaca gttttagtgg ctgtctcagc aatctccagc tcaatggggc ctccatcacc 2400
tctgcttctc agacattcag tgtgacccct tgctttgaag gccccatgga aacaggaact 2460
tacttttcaa cagaaggagg atacgtggtt ctagatgaat ctttcaatat tggattgaag 2520
tttgaaattg catttgaagt ccgtcccaga agcagttccg gaaccctggt ccacggccac 2580
agtgtcaatg gggagtacct aaatgttcac atgaaaaatg gacaggtcat agtgaaagtc 2640
aataatggca tcagagattt ttccacctca gtaacaccca agcagagtct ctgtgatggc 2700
agatggcaca gaattacagt tattagagat tctaatgtgg ttcagttgga tgtggactct 2760
gaagtgaacc atgtggttgg acccctgaat ccaaaaccaa ttgatcacag ggagcctgtg 2820
tttgttggag gtgttccaga atctctactg acaccacgct tggcccccag caaacccttc 2880
acaggctgca tacgccactt tgtgattgat ggacacccag tgagcttcag taaagcagcc 2940
ctggtcagcg gcgccgtaag catcaactcc tgtcca                           2976

<210> 82
<211> 618
<212> DNA
<213> Artificial Sequence

<220> 
<223> LG1 module of G domain of human LAMA4

<400> 82
agcaagatcc aagtctccat gatgtttgat ggccagtcag ctgtggaagt gcactcgaga 60
accagtatgg atgacttaaa ggccttcacg tctctgagcc tgtacatgaa accccctgtg 120
aagcggccgg aactgaccga gactgcagat cagtttatcc tgtacctcgg aagcaaaaac 180
gccaaaaaag agtatatggg tcttgcaatc aaaaatgata atctggtata cgtctataat 240
ttgggaacta aagatgtgga gattcccctg gactccaagc ccgtcagttc ctggcctgct 300
tacttcagca ttgtcaagat tgaaagggtg ggaaaacatg gaaaggtgtt tttaacagtc 360
ccgagtctaa gtagcacagc agaggaaaag ttcattaaaa agggggaatt ttcgggagat 420
gactctctgc tggacctgga ccctgaggac acagtgtttt atgttggtgg agtgccttcc 480
aacttcaagc tccctaccag cttaaacctg cctggctttg ttggctgcct ggaactggcc 540
actttgaata atgatgtgat cagcttgtac aactttaagc acatctataa tatggacccc 600
tccacatcag tgccatgt                                               618

<210> 83
<211> 540
<212> DNA
<213> Artificial Sequence

<220> 
<223> LG2 module of G domain of human LAMA4

<400> 83
gccagttact tcttcgatgg ctccggttat gccgtggtga gagacatcac aaggagaggg 60
aaatttggtc aggtgactcg ctttgacata gaagttcgaa caccagctga caacggcctt 120
attctcctga tggtcaatgg aagtatgttt ttcagactgg aaatgcgcaa tggttaccta 180
catgtgttct atgattttgg attcagcagt ggccgtgtgc atcttgaaga tacgttaaag 240
aaagctcaaa ttaatgatgc aaaataccat gagatctcaa tcatttacca caatgataag 300
aaaatgatct tggtagttga cagaaggcat gtcaagagca tggataatga aaagatgaaa 360
atacctttta cagatatata cattggagga gctcctccag aaatcttaca atccagggcc 420
ctcagagcac accttcccct agatatcaac ttcagaggat gcatgaaggg cttccagttc 480
caaaagaagg acttcaattt actggagcag acagaaaccc tgggagttgg ttatggatgc 540


<210> 84
<211> 507
<212> DNA
<213> Artificial Sequence

<220> 
<223> LG3 module of G domain of human LAMA4

<400> 84
tctcgcagag catatttcaa tggacagagc ttcattgctt caattcagaa aatatctttc 60
tttgatggct ttgaaggagg ttttaatttc cgaacattac aaccaaatgg gttactattc 120
tattatgctt cagggtcaga cgtgttctcc atctcactgg ataatggtac tgtcatcatg 180
gatgtaaagg gaatcaaagt tcagtcagta gataagcagt acaatgatgg gctgtcccac 240
ttcgtcatta gctctgtctc acccacaaga tatgaactga tagtagataa aagcagagtt 300
gggagtaaga atcctaccaa agggaaaata gaacagacac aagcaagtga aaagaagttt 360
tacttcggtg gctcaccaat cagtgctcag tatgctaatt tcactggctg cataagtaat 420
gcctacttta ccagggtgga tagagatgtg gaggttgaag atttccaacg gtatactgaa 480
aaggtccaca cttctcttta tgagtgt                                     507

<210> 85
<211> 1803
<212> DNA
<213> Artificial Sequence

<220> 
<223> LG1-3 modules of G domain of human LAMA4

<400> 85
agcaagatcc aagtctccat gatgtttgat ggccagtcag ctgtggaagt gcactcgaga 60
accagtatgg atgacttaaa ggccttcacg tctctgagcc tgtacatgaa accccctgtg 120
aagcggccgg aactgaccga gactgcagat cagtttatcc tgtacctcgg aagcaaaaac 180
gccaaaaaag agtatatggg tcttgcaatc aaaaatgata atctggtata cgtctataat 240
ttgggaacta aagatgtgga gattcccctg gactccaagc ccgtcagttc ctggcctgct 300
tacttcagca ttgtcaagat tgaaagggtg ggaaaacatg gaaaggtgtt tttaacagtc 360
ccgagtctaa gtagcacagc agaggaaaag ttcattaaaa agggggaatt ttcgggagat 420
gactctctgc tggacctgga ccctgaggac acagtgtttt atgttggtgg agtgccttcc 480
aacttcaagc tccctaccag cttaaacctg cctggctttg ttggctgcct ggaactggcc 540
actttgaata atgatgtgat cagcttgtac aactttaagc acatctataa tatggacccc 600
tccacatcag tgccatgtgc ccgagataag ctggccttca ctcagagtcg ggctgccagt 660
tacttcttcg atggctccgg ttatgccgtg gtgagagaca tcacaaggag agggaaattt 720
ggtcaggtga ctcgctttga catagaagtt cgaacaccag ctgacaacgg ccttattctc 780
ctgatggtca atggaagtat gtttttcaga ctggaaatgc gcaatggtta cctacatgtg 840
ttctatgatt ttggattcag cagtggccgt gtgcatcttg aagatacgtt aaagaaagct 900
caaattaatg atgcaaaata ccatgagatc tcaatcattt accacaatga taagaaaatg 960
atcttggtag ttgacagaag gcatgtcaag agcatggata atgaaaagat gaaaatacct 1020
tttacagata tatacattgg aggagctcct ccagaaatct tacaatccag ggccctcaga 1080
gcacaccttc ccctagatat caacttcaga ggatgcatga agggcttcca gttccaaaag 1140
aaggacttca atttactgga gcagacagaa accctgggag ttggttatgg atgcccagaa 1200
gactcactta tatctcgcag agcatatttc aatggacaga gcttcattgc ttcaattcag 1260
aaaatatctt tctttgatgg ctttgaagga ggttttaatt tccgaacatt acaaccaaat 1320
gggttactat tctattatgc ttcagggtca gacgtgttct ccatctcact ggataatggt 1380
actgtcatca tggatgtaaa gggaatcaaa gttcagtcag tagataagca gtacaatgat 1440
gggctgtccc acttcgtcat tagctctgtc tcacccacaa gatatgaact gatagtagat 1500
aaaagcagag ttgggagtaa gaatcctacc aaagggaaaa tagaacagac acaagcaagt 1560
gaaaagaagt tttacttcgg tggctcacca atcagtgctc agtatgctaa tttcactggc 1620
tgcataagta atgcctactt taccagggtg gatagagatg tggaggttga agatttccaa 1680
cggtatactg aaaaggtcca cacttctctt tatgagtgtc ccattgagtc ttcaccattg 1740
tttctcctcc ataaaaaagg aaaaaattta tccaagccta aagcaagtca gaataaaaag 1800
gga                                                               1803

<210> 86
<211> 513
<212> DNA
<213> Artificial Sequence

<220> 
<223> LG4 module of G domain of human LAMA4

<400> 86
tatcaatatg gaggaacagc caacagccgc caagagtttg aacacttaaa aggagatttt 60
ggtgccaaat ctcagttttc cattcgtctg agaactcgtt cctcccatgg catgatcttc 120
tatgtctcag atcaagaaga gaatgacttc atgactctat ttttggccca tggccgcttg 180
gtttacatgt ttaatgttgg tcacaaaaaa ctgaagatta gaagccagga gaaatacaat 240
gatggcctgt ggcatgatgt gatatttatt cgagaaagga gcagtggccg actggtaatt 300
gatggtctcc gagtcctaga agaaagtctt cctcctactg aagctacctg gaaaatcaag 360
ggtcccattt atttgggagg tgtggctcct ggaaaggctg tgaaaaatgt tcagattaac 420
tccatctaca gttttagtgg ctgtctcagc aatctccagc tcaatggggc ctccatcacc 480
tctgcttctc agacattcag tgtgacccct tgc                              513

<210> 87
<211> 522
<212> DNA
<213> Artificial Sequence

<220> 
<223> LG5 module of G domain of human LAMA4

<400> 87
acaggaactt acttttcaac agaaggagga tacgtggttc tagatgaatc tttcaatatt 60
ggattgaagt ttgaaattgc atttgaagtc cgtcccagaa gcagttccgg aaccctggtc 120
cacggccaca gtgtcaatgg ggagtaccta aatgttcaca tgaaaaatgg acaggtcata 180
gtgaaagtca ataatggcat cagagatttt tccacctcag taacacccaa gcagagtctc 240
tgtgatggca gatggcacag aattacagtt attagagatt ctaatgtggt tcagttggat 300
gtggactctg aagtgaacca tgtggttgga cccctgaatc caaaaccaat tgatcacagg 360
gagcctgtgt ttgttggagg tgttccagaa tctctactga caccacgctt ggcccccagc 420
aaacccttca caggctgcat acgccacttt gtgattgatg gacacccagt gagcttcagt 480
aaagcagccc tggtcagcgg cgccgtaagc atcaactcct gt                    522

<210> 88
<211> 1107
<212> DNA
<213> Artificial Sequence

<220> 
<223> LG4-5 modules of G domain of human LAMA4

<400> 88
agaaactctc attgccacct ttccaacagc cctagagcaa tagagcacgc ctatcaatat 60
ggaggaacag ccaacagccg ccaagagttt gaacacttaa aaggagattt tggtgccaaa 120
tctcagtttt ccattcgtct gagaactcgt tcctcccatg gcatgatctt ctatgtctca 180
gatcaagaag agaatgactt catgactcta tttttggccc atggccgctt ggtttacatg 240
tttaatgttg gtcacaaaaa actgaagatt agaagccagg agaaatacaa tgatggcctg 300
tggcatgatg tgatatttat tcgagaaagg agcagtggcc gactggtaat tgatggtctc 360
cgagtcctag aagaaagtct tcctcctact gaagctacct ggaaaatcaa gggtcccatt 420
tatttgggag gtgtggctcc tggaaaggct gtgaaaaatg ttcagattaa ctccatctac 480
agttttagtg gctgtctcag caatctccag ctcaatgggg cctccatcac ctctgcttct 540
cagacattca gtgtgacccc ttgctttgaa ggccccatgg aaacaggaac ttacttttca 600
acagaaggag gatacgtggt tctagatgaa tctttcaata ttggattgaa gtttgaaatt 660
gcatttgaag tccgtcccag aagcagttcc ggaaccctgg tccacggcca cagtgtcaat 720
ggggagtacc taaatgttca catgaaaaat ggacaggtca tagtgaaagt caataatggc 780
atcagagatt tttccacctc agtaacaccc aagcagagtc tctgtgatgg cagatggcac 840
agaattacag ttattagaga ttctaatgtg gttcagttgg atgtggactc tgaagtgaac 900
catgtggttg gacccctgaa tccaaaacca attgatcaca gggagcctgt gtttgttgga 960
ggtgttccag aatctctact gacaccacgc ttggccccca gcaaaccctt cacaggctgc 1020
atacgccact ttgtgattga tggacaccca gtgagcttca gtaaagcagc cctggtcagc 1080
ggcgccgtaa gcatcaactc ctgtcca                                     1107

<210> 89
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human IgG1 constant region of IgG1 G1m3
      allotype

<400> 89
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 90
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human kappa light chain constant region
      with a N-terminal arginine

<400> 90
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
 1               5                  10                  15      
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
            20                  25                  30          
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
        35                  40                  45              
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
    50                  55                  60                  
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
65                  70                  75                  80  
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
                85                  90                  95      
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105         


<210> 91
<211> 329
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human IgG1 constant region without a
      C-terminal lysine

<400> 91
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Val Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly
                325                 


<210> 92
<211> 990
<212> DNA
<213> Artificial Sequence

<220> 
<223> Exemplary human IgG1 constant region of IgG1 G1m3
      allotype

<400> 92
gcctccacca agggtccatc ggtcttcccc ctggcaccct cctccaagag cacctctggg 60
ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg 120
tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca 180
ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc 240
tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc 300
aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga 360
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct 420
gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg 480
tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac 540
agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag 600
gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc 660
aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag 720
atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc 780
gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg 840
ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg 900
cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg 960
cagaagagcc tctccctgtc cccgggtaaa                                  990

<210> 93
<211> 321
<212> DNA
<213> Artificial Sequence

<220> 
<223> Exemplary human kappa light chain constant region
      with a N-terminal arginine

<400> 93
cgaactgtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct 60
ggaactgcct ctgttgtgtg cctgctgaat aacttctatc ccagagaggc caaagtacag 120
tggaaggtgg ataacgccct ccaatcgggt aactcccagg agagtgtcac agagcaggac 180
agcaaggaca gcacctacag cctcagcagc accctgacgc tgagcaaagc agactacgag 240
aaacacaaag tctacgcctg cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag 300
agcttcaaca ggggagagtg t                                           321

<210> 94
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> 6C12 mature light chain variable region, v2

<400> 94
Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Thr Val Thr Ala Gly
 1               5                  10                  15      
Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser
            20                  25                  30          
Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln
        35                  40                  45              
Pro Pro Lys Val Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val
    50                  55                  60                  
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80  
Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Asn
                85                  90                  95      
Asp Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
            100                 105                 110         
Lys Arg
        


<210> 95
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> 6C12 CDR-L1, v2

<400> 95
Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu
 1               5                  10                  15      
Thr
    


<210> 96
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human VH acceptor FR, v3

<400> 96
Gln Val Gln Leu Val Gln Ser Gly Thr Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile Ile Pro Ile Val Gly Ile Gly Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ala Val Asp Phe Asp Ser Ser Ser Ser Tyr Ser Phe Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 97
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human VH acceptor FR, v4

<400> 97
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45              
Gly Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Asp Thr His Ser Trp Phe Ala Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Met Val Thr Val Ser Ser
        115                 


<210> 98
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Human VL acceptor FR, v3

<400> 98
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Gly Gln Gly Ile Ser Asn Ser
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu
        35                  40                  45              
Tyr Ala Ala Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Thr Pro Gln
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg
            100                 105             


<210> 99
<211> 342
<212> DNA
<213> Artificial Sequence

<220> 
<223> 6C12 mature light chain variable region, v2

<400> 99
gacattgtga tgacacagtc tccatcctcc ctgactgtga cagcaggaga gaaggtcact 60
atgagctgca agtccagtca gagtctatta aacagtggaa atcaaaagaa ctacttgacc 120
tggtaccaac agaaaccagg gcagcctcct aaagtgttga tctactgggc atccactagg 180
gaatctgggg tccctgatcg cttcacaggc agtggatctg gaacagattt cactctcacc 240
atcagcagtg tgcaggctga agacctggca gtttattact gtcagaatga ttatagttat 300
ccgctcacgt tcggtgctgg gaccaagctg gagctgaaac gg                    342

<210> 100
<211> 324
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic

<400> 100
gacatccaga tgacacaatc ttcatcctcc ctttctgcat ctgtaggaga cagagtcacc 60
attacttgca aggcaagtga ggacatatat aatcggttag cctggtatca gcagaaacca 120
ggaaatgctc ctaggctctt aatatctggt gcaaccagtt tggaaactgg ggttccttca 180
agattcagtg gcagtggatc tggaaaggat tacactctca ccattagcag tcttcagact 240
gaagattttg ctacttatta ctgtcaacag tattggagta ttccgtacac gttcggaggg 300
gggaccaaat tggaaataaa acgt                                        324

<210> 101
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> Exemplary human IgG1 constant region of IgG1 G1m3
      allotype

<400> 101
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
225                 230                 235                 240 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 102
<211> 318
<212> DNA
<213> Artificial Sequence

<220> 
<223> Exemplary human kappa light chain constant region
      without a N-terminal arginine

<400> 102
actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 60
actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg 120
aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc 180
aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa 240
cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc 300
ttcaacaggg gagagtgt                                               318
