                         SEQUENCE LISTING

<110>  UNIVERSITE JOSEPH FOURIER
 
<120>  NEW PHARMACEUTICAL COMPOSITIONS AND THEIR USE FOR THE TREATMENT 
       OF AUTOIMMUNE DISORDERS

<130>  WOB 14 AJ UJF APRI

<140>  EP 14305362.7
<141>  2014-03-13

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  136
<212>  PRT
<213>  Homo Sapiens

<400>  1

His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys Asp Asp 
1               5                   10                  15      


Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg Gly Arg 
            20                  25                  30          


Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly Val 
        35                  40                  45              


Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe Thr Met 
    50                  55                  60                  


Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe 
65                  70                  75                  80  


Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr Asn Ser 
                85                  90                  95      


Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile Leu Ser 
            100                 105                 110         


Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro His Gly 
        115                 120                 125             


Thr Phe Leu Gly Phe Val Lys Leu 
    130                 135     


<210>  2
<211>  146
<212>  PRT
<213>  Homo Sapiens

<400>  2

Ala Val Leu Thr Gln Lys Gln Lys Lys Gln His Ser Val Leu His Leu 
1               5                   10                  15      


Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val 
            20                  25                  30          


Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly 
        35                  40                  45              


Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln 
    50                  55                  60                  


Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg 
65                  70                  75                  80  


Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met 
                85                  90                  95      


Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val 
            100                 105                 110         


Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala 
        115                 120                 125             


Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val 
    130                 135                 140                 


Lys Leu 
145     


<210>  3
<211>  233
<212>  PRT
<213>  Homo Sapiens

<400>  3

Met Gly Gly Pro Val Arg Glu Pro Ala Leu Ser Val Ala Leu Trp Leu 
1               5                   10                  15      


Ser Trp Gly Ala Ala Leu Gly Ala Val Ala Cys Ala Met Ala Leu Leu 
            20                  25                  30          


Thr Gln Gln Thr Glu Leu Gln Ser Leu Arg Arg Glu Val Ser Arg Leu 
        35                  40                  45              


Gln Gly Thr Gly Gly Pro Ser Gln Asn Gly Glu Gly Tyr Pro Trp Gln 
    50                  55                  60                  


Ser Leu Pro Glu Gln Ser Ser Asp Ala Leu Glu Ala Trp Glu Asn Gly 
65                  70                  75                  80  


Glu Arg Ser Arg Lys Arg Arg Ala Val Leu Thr Gln Lys Gln Lys Lys 
                85                  90                  95      


Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys Asp 
            100                 105                 110         


Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg Gly 
        115                 120                 125             


Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly 
    130                 135                 140                 


Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe Thr 
145                 150                 155                 160 


Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu 
                165                 170                 175     


Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr Asn 
            180                 185                 190         


Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile Leu 
        195                 200                 205             


Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro His 
    210                 215                 220                 


Gly Thr Phe Leu Gly Phe Val Lys Leu 
225                 230             


<210>  4
<211>  411
<212>  DNA
<213>  Homo Sapiens

<400>  4
cactctgtcc tgcacctggt tcccattaac gccacctcca aggatgactc cgatgtgaca       60

gaggtgatgt ggcaaccagc tcttaggcgt gggagaggcc tacaggccca aggatatggt      120

gtccgaatcc aggatgctgg agtttatctg ctgtatagcc aggtcctgtt tcaagacgtg      180

actttcacca tgggtcaggt ggtgtctcga gaaggccaag gaaggcagga gactctattc      240

cgatgtataa gaagtatgcc ctcccacccg gaccgggcct acaacagctg ctatagcgca      300

ggtgtcttcc atttacacca aggggatatt ctgagtgtca taattccccg ggcaagggcg      360

aaacttaacc tctctccaca tggaaccttc ctggggtttg tgaaactgtg a               411


<210>  5
<211>  441
<212>  DNA
<213>  Homo Sapiens

<400>  5
gcagtgctca cccaaaaaca gaagaagcag cactctgtcc tgcacctggt tcccattaac       60

gccacctcca aggatgactc cgatgtgaca gaggtgatgt ggcaaccagc tcttaggcgt      120

gggagaggcc tacaggccca aggatatggt gtccgaatcc aggatgctgg agtttatctg      180

ctgtatagcc aggtcctgtt tcaagacgtg actttcacca tgggtcaggt ggtgtctcga      240

gaaggccaag gaaggcagga gactctattc cgatgtataa gaagtatgcc ctcccacccg      300

gaccgggcct acaacagctg ctatagcgca ggtgtcttcc atttacacca aggggatatt      360

ctgagtgtca taattccccg ggcaagggcg aaacttaacc tctctccaca tggaaccttc      420

ctggggtttg tgaaactgtg a                                                441


<210>  6
<211>  702
<212>  DNA
<213>  Homo Sapiens

<400>  6
atggggggcc cagtcagaga gccggcactc tcagttgccc tctggttgag ttggggggca       60

gctctggggg ccgtggcttg tgccatggct ctgctgaccc aacaaacaga gctgcagagc      120

ctcaggagag aggtgagccg gctgcagggg acaggaggcc cctcccagaa tggggaaggg      180

tatccctggc agagtctccc ggagcagagt tccgatgccc tggaagcctg ggagaatggg      240

gagagatccc ggaaaaggag agcagtgctc acccaaaaac agaagaagca gcactctgtc      300

ctgcacctgg ttcccattaa cgccacctcc aaggatgact ccgatgtgac agaggtgatg      360

tggcaaccag ctcttaggcg tgggagaggc ctacaggccc aaggatatgg tgtccgaatc      420

caggatgctg gagtttatct gctgtatagc caggtcctgt ttcaagacgt gactttcacc      480

atgggtcagg tggtgtctcg agaaggccaa ggaaggcagg agactctatt ccgatgtata      540

agaagtatgc cctcccaccc ggaccgggcc tacaacagct gctatagcgc aggtgtcttc      600

catttacacc aaggggatat tctgagtgtc ataattcccc gggcaagggc gaaacttaac      660

ctctctccac atggaacctt cctggggttt gtgaaactgt ga                         702


<210>  7
<211>  239
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric protein

<400>  7

His Asp Gln Glu Thr Thr Thr Gln Gly Pro Gly Val Leu Leu Pro Leu 
1               5                   10                  15      


Pro Lys Gly Ala Cys Thr Gly Trp Met Ala Gly Ile Pro Gly His Pro 
            20                  25                  30          


Gly His Asn Gly Ala Pro Gly Arg Asp Gly Arg Asp Gly Thr Pro Gly 
        35                  40                  45              


Glu Lys Gly Glu Lys Gly Asp Pro Gly Leu Ile Gly Pro Lys Gly Asp 
    50                  55                  60                  


Ile Gly Glu Thr Gly Val Pro Gly Ala Glu Gly Pro Arg Gly Phe Pro 
65                  70                  75                  80  


Gly Ile Gln Gly Arg Lys Gly Glu Pro Gly Glu Gly Ala Ala Val Leu 
                85                  90                  95      


Thr Gln Lys Gln Lys Lys Gln His Ser Val Leu His Leu Val Pro Ile 
            100                 105                 110         


Asn Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu Val Met Trp Gln 
        115                 120                 125             


Pro Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val 
    130                 135                 140                 


Arg Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe 
145                 150                 155                 160 


Gln Asp Val Thr Phe Thr Met Gly Gln Val Val Ser Arg Glu Gly Gln 
                165                 170                 175     


Gly Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser Met Pro Ser His 
            180                 185                 190         


Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly Val Phe His Leu 
        195                 200                 205             


His Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg Ala Arg Ala Lys 
    210                 215                 220                 


Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe Val Lys Leu 
225                 230                 235                 


<210>  8
<211>  229
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric protein

<400>  8

His Asp Gln Glu Thr Thr Thr Gln Gly Pro Gly Val Leu Leu Pro Leu 
1               5                   10                  15      


Pro Lys Gly Ala Cys Thr Gly Trp Met Ala Gly Ile Pro Gly His Pro 
            20                  25                  30          


Gly His Asn Gly Ala Pro Gly Arg Asp Gly Arg Asp Gly Thr Pro Gly 
        35                  40                  45              


Glu Lys Gly Glu Lys Gly Asp Pro Gly Leu Ile Gly Pro Lys Gly Asp 
    50                  55                  60                  


Ile Gly Glu Thr Gly Val Pro Gly Ala Glu Gly Pro Arg Gly Phe Pro 
65                  70                  75                  80  


Gly Ile Gln Gly Arg Lys Gly Glu Pro Gly Glu Gly Ala His Ser Val 
                85                  90                  95      


Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser Asp Val 
            100                 105                 110         


Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu Gln 
        115                 120                 125             


Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu Leu 
    130                 135                 140                 


Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln Val 
145                 150                 155                 160 


Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys Ile 
                165                 170                 175     


Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser 
            180                 185                 190         


Ala Gly Val Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile Ile 
        195                 200                 205             


Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe Leu 
    210                 215                 220                 


Gly Phe Val Lys Leu 
225                 


<210>  9
<211>  387
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric protein

<400>  9

Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
1               5                   10                  15      


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            20                  25                  30          


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        35                  40                  45              


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    50                  55                  60                  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
65                  70                  75                  80  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                85                  90                  95      


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            100                 105                 110         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        115                 120                 125             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    130                 135                 140                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
145                 150                 155                 160 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                165                 170                 175     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Ser Pro 
    210                 215                 220                 


Gln Pro Gln Pro Lys Pro Gln Pro Lys Pro Glu Pro Glu Gly Ser Leu 
225                 230                 235                 240 


Gln Ala Val Leu Thr Gln Lys Gln Lys Lys Gln His Ser Val Leu His 
                245                 250                 255     


Leu Val Pro Ile Asn Ala Thr Ser Lys Asp Asp Ser Asp Val Thr Glu 
            260                 265                 270         


Val Met Trp Gln Pro Ala Leu Arg Arg Gly Arg Gly Leu Gln Ala Gln 
        275                 280                 285             


Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly Val Tyr Leu Leu Tyr Ser 
    290                 295                 300                 


Gln Val Leu Phe Gln Asp Val Thr Phe Thr Met Gly Gln Val Val Ser 
305                 310                 315                 320 


Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu Phe Arg Cys Ile Arg Ser 
                325                 330                 335     


Met Pro Ser His Pro Asp Arg Ala Tyr Asn Ser Cys Tyr Ser Ala Gly 
            340                 345                 350         


Val Phe His Leu His Gln Gly Asp Ile Leu Ser Val Ile Ile Pro Arg 
        355                 360                 365             


Ala Arg Ala Lys Leu Asn Leu Ser Pro His Gly Thr Phe Leu Gly Phe 
    370                 375                 380                 


Val Lys Leu 
385         


<210>  10
<211>  377
<212>  PRT
<213>  Artificial sequence

<220>
<223>  chimeric protein

<400>  10

Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
1               5                   10                  15      


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            20                  25                  30          


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        35                  40                  45              


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    50                  55                  60                  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
65                  70                  75                  80  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                85                  90                  95      


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            100                 105                 110         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        115                 120                 125             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    130                 135                 140                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
145                 150                 155                 160 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                165                 170                 175     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Arg Ser Pro 
    210                 215                 220                 


Gln Pro Gln Pro Lys Pro Gln Pro Lys Pro Glu Pro Glu Gly Ser Leu 
225                 230                 235                 240 


Gln His Ser Val Leu His Leu Val Pro Ile Asn Ala Thr Ser Lys Asp 
                245                 250                 255     


Asp Ser Asp Val Thr Glu Val Met Trp Gln Pro Ala Leu Arg Arg Gly 
            260                 265                 270         


Arg Gly Leu Gln Ala Gln Gly Tyr Gly Val Arg Ile Gln Asp Ala Gly 
        275                 280                 285             


Val Tyr Leu Leu Tyr Ser Gln Val Leu Phe Gln Asp Val Thr Phe Thr 
    290                 295                 300                 


Met Gly Gln Val Val Ser Arg Glu Gly Gln Gly Arg Gln Glu Thr Leu 
305                 310                 315                 320 


Phe Arg Cys Ile Arg Ser Met Pro Ser His Pro Asp Arg Ala Tyr Asn 
                325                 330                 335     


Ser Cys Tyr Ser Ala Gly Val Phe His Leu His Gln Gly Asp Ile Leu 
            340                 345                 350         


Ser Val Ile Ile Pro Arg Ala Arg Ala Lys Leu Asn Leu Ser Pro His 
        355                 360                 365             


Gly Thr Phe Leu Gly Phe Val Lys Leu 
    370                 375         


<210>  11
<211>  93
<212>  PRT
<213>  Homo Sapiens

<400>  11

His Asp Gln Glu Thr Thr Thr Gln Gly Pro Gly Val Leu Leu Pro Leu 
1               5                   10                  15      


Pro Lys Gly Ala Cys Thr Gly Trp Met Ala Gly Ile Pro Gly His Pro 
            20                  25                  30          


Gly His Asn Gly Ala Pro Gly Arg Asp Gly Arg Asp Gly Thr Pro Gly 
        35                  40                  45              


Glu Lys Gly Glu Lys Gly Asp Pro Gly Leu Ile Gly Pro Lys Gly Asp 
    50                  55                  60                  


Ile Gly Glu Thr Gly Val Pro Gly Ala Glu Gly Pro Arg Gly Phe Pro 
65                  70                  75                  80  


Gly Ile Gln Gly Arg Lys Gly Glu Pro Gly Glu Gly Ala 
                85                  90              


<210>  12
<211>  221
<212>  PRT
<213>  Homo Sapiens

<400>  12

Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
1               5                   10                  15      


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            20                  25                  30          


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        35                  40                  45              


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    50                  55                  60                  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
65                  70                  75                  80  


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                85                  90                  95      


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            100                 105                 110         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        115                 120                 125             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    130                 135                 140                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
145                 150                 155                 160 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                165                 170                 175     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            180                 185                 190         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        195                 200                 205             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220     


<210>  13
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  linker sequence

<400>  13

Arg Ser Pro Gln Pro Gln Pro Lys Pro Gln Pro Lys Pro Glu Pro Glu 
1               5                   10                  15      


Gly Ser Leu Gln 
            20  


<210>  14
<211>  720
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chimeric protein

<400>  14
catgaccagg aaaccacgac tcaagggccc ggagtcctgc ttcccctgcc caagggggcc       60

tgcacaggtt ggatggcggg catcccaggg catccgggcc ataatggggc cccaggccgt      120

gatggcagag atggcacccc tggtgagaag ggtgagaaag gagatccagg tcttattggt      180

cctaagggag acatcggtga aaccggagta cccggggctg aaggtccccg aggctttccg      240

ggaatccaag gcaggaaagg agaacctgga gaaggtgccg cagtgctcac ccaaaaacag      300

aagaagcagc actctgtcct gcacctggtt cccattaacg ccacctccaa ggatgactcc      360

gatgtgacag aggtgatgtg gcaaccagct cttaggcgtg ggagaggcct acaggcccaa      420

ggatatggtg tccgaatcca ggatgctgga gtttatctgc tgtatagcca ggtcctgttt      480

caagacgtga ctttcaccat gggtcaggtg gtgtctcgag aaggccaagg aaggcaggag      540

actctattcc gatgtataag aagtatgccc tcccacccgg accgggccta caacagctgc      600

tatagcgcag gtgtcttcca tttacaccaa ggggatattc tgagtgtcat aattccccgg      660

gcaagggcga aacttaacct ctctccacat ggaaccttcc tggggtttgt gaaactgtga      720


<210>  15
<211>  690
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chimeric protein

<400>  15
catgaccagg aaaccacgac tcaagggccc ggagtcctgc ttcccctgcc caagggggcc       60

tgcacaggtt ggatggcggg catcccaggg catccgggcc ataatggggc cccaggccgt      120

gatggcagag atggcacccc tggtgagaag ggtgagaaag gagatccagg tcttattggt      180

cctaagggag acatcggtga aaccggagta cccggggctg aaggtccccg aggctttccg      240

ggaatccaag gcaggaaagg agaacctgga gaaggtgccc actctgtcct gcacctggtt      300

cccattaacg ccacctccaa ggatgactcc gatgtgacag aggtgatgtg gcaaccagct      360

cttaggcgtg ggagaggcct acaggcccaa ggatatggtg tccgaatcca ggatgctgga      420

gtttatctgc tgtatagcca ggtcctgttt caagacgtga ctttcaccat gggtcaggtg      480

gtgtctcgag aaggccaagg aaggcaggag actctattcc gatgtataag aagtatgccc      540

tcccacccgg accgggccta caacagctgc tatagcgcag gtgtcttcca tttacaccaa      600

ggggatattc tgagtgtcat aattccccgg gcaagggcga aacttaacct ctctccacat      660

ggaaccttcc tggggtttgt gaaactgtga                                       690


<210>  16
<211>  1227
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chimeric protein

<400>  16
atggctatca tctacctcat cctcctgttc accgctgtgc ggggcctcga caaaactcac       60

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      120

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      180

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      240

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      300

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      360

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga      420

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc      480

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat      540

gggcagccgg agaacaacta caagaccacg cctcccgtgt tggactccga cggctccttc      600

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca      660

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct      720

ccgggtaaaa gatctccgca gccgcagccg aaaccgcagc cgaaaccgga accggaagga      780

tccctgcagg cagtgctcac ccaaaaacag aagaagcagc actctgtcct gcacctggtt      840

cccattaacg ccacctccaa ggatgactcc gatgtgacag aggtgatgtg gcaaccagct      900

cttaggcgtg ggagaggcct acaggcccaa ggatatggtg tccgaatcca ggatgctgga      960

gtttatctgc tgtatagcca ggtcctgttt caagacgtga ctttcaccat gggtcaggtg     1020

gtgtctcgag aaggccaagg aaggcaggag actctattcc gatgtataag aagtatgccc     1080

tcccacccgg accgggccta caacagctgc tatagcgcag gtgtcttcca tttacaccaa     1140

ggggatattc tgagtgtcat aattccccgg gcaagggcga aacttaacct ctctccacat     1200

ggaaccttcc tggggtttgt gaaactg                                         1227


<210>  17
<211>  1197
<212>  DNA
<213>  Artificial sequence

<220>
<223>  chimeric protein

<400>  17
atggctatca tctacctcat cctcctgttc accgctgtgc ggggcctcga caaaactcac       60

acatgcccac cgtgcccagc acctgaactc ctggggggac cgtcagtctt cctcttcccc      120

ccaaaaccca aggacaccct catgatctcc cggacccctg aggtcacatg cgtggtggtg      180

gacgtgagcc acgaagaccc tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg      240

cataatgcca agacaaagcc gcgggaggag cagtacaaca gcacgtaccg tgtggtcagc      300

gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg caaggtctcc      360

aacaaagccc tcccagcccc catcgagaaa accatctcca aagccaaagg gcagccccga      420

gaaccacagg tgtacaccct gcccccatcc cgggatgagc tgaccaagaa ccaggtcagc      480

ctgacctgcc tggtcaaagg cttctatccc agcgacatcg ccgtggagtg ggagagcaat      540

gggcagccgg agaacaacta caagaccacg cctcccgtgt tggactccga cggctccttc      600

ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa cgtcttctca      660

tgctccgtga tgcatgaggc tctgcacaac cactacacgc agaagagcct ctccctgtct      720

ccgggtaaaa gatctccgca gccgcagccg aaaccgcagc cgaaaccgga accggaagga      780

tccctgcagc actctgtcct gcacctggtt cccattaacg ccacctccaa ggatgactcc      840

gatgtgacag aggtgatgtg gcaaccagct cttaggcgtg ggagaggcct acaggcccaa      900

ggatatggtg tccgaatcca ggatgctgga gtttatctgc tgtatagcca ggtcctgttt      960

caagacgtga ctttcaccat gggtcaggtg gtgtctcgag aaggccaagg aaggcaggag     1020

actctattcc gatgtataag aagtatgccc tcccacccgg accgggccta caacagctgc     1080

tatagcgcag gtgtcttcca tttacaccaa ggggatattc tgagtgtcat aattccccgg     1140

gcaagggcga aacttaacct ctctccacat ggaaccttcc tggggtttgt gaaactg        1197


